BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51057172 CCN(Cc1cccc(OC)c1)C(=O)Nc1ccc(cc1O[C@H]1CCN(C)C1)-c1cn[nH]c1 InChI=1S/C25H31N5O3/c1-4-30(16-18-6-5-7-21(12-18)32-3)25(31)28-23-9-8-19(20-14-26-27-15-20)13-24(23)33-22-10-11-29(2)17-22/h5-9,12-15,22H,4,10-11,16-17H2,1-3H3,(H,26,27)(H,28,31)/t22-/m0/s1 LJQLCPYRTIQYAH-QFIPXVFZSA-N 50431137 CHEMBL2332060 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm400062r 10.7270/Q28C9XMJ 23570561 Yin, Y; Lin, L; Ruiz, C; Khan, S; Cameron, MD; Grant, W; Pocas, J; Eid, N; Park, H; Schroter, T; Lograsso, PV; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431137&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71655603 164160012 CHEMBL2332060 ZINC95585894 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51057173 OCCC(NC(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(F)c1 InChI=1S/C19H19FN4O2/c20-16-3-1-2-14(10-16)18(8-9-25)24-19(26)23-17-6-4-13(5-7-17)15-11-21-22-12-15/h1-7,10-12,18,25H,8-9H2,(H,21,22)(H2,23,24,26) BNSKTIACOBJLNV-UHFFFAOYSA-N 50431131 CHEMBL2332056 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm400062r 10.7270/Q28C9XMJ 23570561 Yin, Y; Lin, L; Ruiz, C; Khan, S; Cameron, MD; Grant, W; Pocas, J; Eid, N; Park, H; Schroter, T; Lograsso, PV; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431131&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68566254 164160006 CHEMBL2332056 ZINC95591133 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51057174 COc1cccc(CN(CCN2CCCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 InChI=1S/C25H31N5O2/c1-32-24-7-5-6-20(16-24)19-30(15-14-29-12-3-2-4-13-29)25(31)28-23-10-8-21(9-11-23)22-17-26-27-18-22/h5-11,16-18H,2-4,12-15,19H2,1H3,(H,26,27)(H,28,31) VRZUDQNRTCEYKK-UHFFFAOYSA-N 50431124 CHEMBL2332073 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm400062r 10.7270/Q28C9XMJ 23570561 Yin, Y; Lin, L; Ruiz, C; Khan, S; Cameron, MD; Grant, W; Pocas, J; Eid, N; Park, H; Schroter, T; Lograsso, PV; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431124&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68565200 164159999 CHEMBL2332073 ZINC95590347 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51057175 COc1cccc(CN(CCN2CCOCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 InChI=1S/C24H29N5O3/c1-31-23-4-2-3-19(15-23)18-29(10-9-28-11-13-32-14-12-28)24(30)27-22-7-5-20(6-8-22)21-16-25-26-17-21/h2-8,15-17H,9-14,18H2,1H3,(H,25,26)(H,27,30) GQMCGRYPKMDMGV-UHFFFAOYSA-N 50431127 CHEMBL2332071 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm400062r 10.7270/Q28C9XMJ 23570561 Yin, Y; Lin, L; Ruiz, C; Khan, S; Cameron, MD; Grant, W; Pocas, J; Eid, N; Park, H; Schroter, T; Lograsso, PV; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431127&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68561431 164160002 CHEMBL2332071 ZINC95589704 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51057176 COc1cccc(CN(CCN2CCCC2)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 InChI=1S/C24H29N5O2/c1-31-23-6-4-5-19(15-23)18-29(14-13-28-11-2-3-12-28)24(30)27-22-9-7-20(8-10-22)21-16-25-26-17-21/h4-10,15-17H,2-3,11-14,18H2,1H3,(H,25,26)(H,27,30) FXVIJUPKVPPUNX-UHFFFAOYSA-N 50431126 CHEMBL2332069 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm400062r 10.7270/Q28C9XMJ 23570561 Yin, Y; Lin, L; Ruiz, C; Khan, S; Cameron, MD; Grant, W; Pocas, J; Eid, N; Park, H; Schroter, T; Lograsso, PV; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431126&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68567556 164160001 CHEMBL2332069 ZINC95590766 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51057177 COc1cccc(CN(CCN(C)C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 InChI=1S/C22H27N5O2/c1-26(2)11-12-27(16-17-5-4-6-21(13-17)29-3)22(28)25-20-9-7-18(8-10-20)19-14-23-24-15-19/h4-10,13-15H,11-12,16H2,1-3H3,(H,23,24)(H,25,28) KACIGJBSABVNRF-UHFFFAOYSA-N 50431134 CHEMBL2332068 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm400062r 10.7270/Q28C9XMJ 23570561 Yin, Y; Lin, L; Ruiz, C; Khan, S; Cameron, MD; Grant, W; Pocas, J; Eid, N; Park, H; Schroter, T; Lograsso, PV; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431134&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68563058 164160009 CHEMBL2332068 ZINC95586834 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51057178 COc1cccc(CN(CCO)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 InChI=1S/C20H22N4O3/c1-27-19-4-2-3-15(11-19)14-24(9-10-25)20(26)23-18-7-5-16(6-8-18)17-12-21-22-13-17/h2-8,11-13,25H,9-10,14H2,1H3,(H,21,22)(H,23,26) NGOKTEXAUPRBFP-UHFFFAOYSA-N 50431135 CHEMBL2332065 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm400062r 10.7270/Q28C9XMJ 23570561 Yin, Y; Lin, L; Ruiz, C; Khan, S; Cameron, MD; Grant, W; Pocas, J; Eid, N; Park, H; Schroter, T; Lograsso, PV; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431135&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68560854 164160010 CHEMBL2332065 ZINC95588458 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51057179 COc1cccc(CN(C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1 InChI=1S/C19H20N4O2/c1-23(13-14-4-3-5-18(10-14)25-2)19(24)22-17-8-6-15(7-9-17)16-11-20-21-12-16/h3-12H,13H2,1-2H3,(H,20,21)(H,22,24) MTJPSOHLRSAFBG-UHFFFAOYSA-N 50431138 CHEMBL2332097 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm400062r 10.7270/Q28C9XMJ 23570561 Yin, Y; Lin, L; Ruiz, C; Khan, S; Cameron, MD; Grant, W; Pocas, J; Eid, N; Park, H; Schroter, T; Lograsso, PV; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431138&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68568011 164160013 CHEMBL2332097 ZINC95589296 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28540 CN(C)C(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1ccccc1 InChI=1S/C16H16N4O/c1-20(2)16(21)14-8-12(9-17-14)15-13(10-18-19-15)11-6-4-3-5-7-11/h3-10,17H,1-2H3,(H,18,19) OPBUUQBZKJSWTN-UHFFFAOYSA-N 15614 N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 1 Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15614&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 19A 2OJG 6096886 46515905 DB06877 ZINC20149026 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28541 CCN(C)C(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1 InChI=1S/C17H17ClN4O/c1-3-22(2)17(23)15-8-12(9-19-15)16-14(10-20-21-16)11-5-4-6-13(18)7-11/h4-10,19H,3H2,1-2H3,(H,20,21) SVGGWCSPGCMEAQ-UHFFFAOYSA-N 15615 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-ethyl-N-methyl-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-ethyl-N-methyl-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 5a Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15615&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647148 46515906 ZINC14959109 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28542 Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)N1CCCC1 InChI=1S/C18H17ClN4O/c19-14-5-3-4-12(8-14)15-11-21-22-17(15)13-9-16(20-10-13)18(24)23-6-1-2-7-23/h3-5,8-11,20H,1-2,6-7H2,(H,21,22) JVFFNJBBYLKYSH-UHFFFAOYSA-N 15616 4-(3-chlorophenyl)-3-[5-(pyrrolidin-1-ylcarbonyl)-1H-pyrrol-3-yl]-1H-pyrazole::4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrol-2-yl)(pyrrolidin-1-yl)methanone::Pyrrole Carboxamide Analog 5b Mitogen-activated protein kinase 10 Homo sapiens 1800 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15616&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647149 46515907 ZINC14959113 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28543 Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)N1CCOCC1 InChI=1S/C18H17ClN4O2/c19-14-3-1-2-12(8-14)15-11-21-22-17(15)13-9-16(20-10-13)18(24)23-4-6-25-7-5-23/h1-3,8-11,20H,4-7H2,(H,21,22) IQQCVFADEOAMTK-UHFFFAOYSA-N 15617 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrol-2-yl)(morpholino)methanone::4-({4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrol-2-yl}carbonyl)morpholine::Pyrrole Carboxamide Analog 5c Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15617&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647150 46515908 ZINC14959117 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28544 Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)NCC1CCCO1 InChI=1S/C19H19ClN4O2/c20-14-4-1-3-12(7-14)16-11-23-24-18(16)13-8-17(21-9-13)19(25)22-10-15-5-2-6-26-15/h1,3-4,7-9,11,15,21H,2,5-6,10H2,(H,22,25)(H,23,24) HKKKUFBFJIIVRA-UHFFFAOYSA-N 15618 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-((tetrahydrofuran-2-yl)methyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-(oxolan-2-ylmethyl)-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 5d Mitogen-activated protein kinase 10 Homo sapiens 2700 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15618&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647151 46515909 ZINC14959126 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28545 CCN1CCCC1CNC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1 InChI=1S/C21H24ClN5O/c1-2-27-8-4-7-17(27)12-24-21(28)19-10-15(11-23-19)20-18(13-25-26-20)14-5-3-6-16(22)9-14/h3,5-6,9-11,13,17,23H,2,4,7-8,12H2,1H3,(H,24,28)(H,25,26) FYNXWPSWTKNQFN-UHFFFAOYSA-N 15619 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-((1-ethylpyrrolidin-2-yl)methyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[(1-ethylpyrrolidin-2-yl)methyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 5e Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15619&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647152 46515910 ZINC14959137 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28546 Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)NCc1ccccc1 InChI=1S/C21H17ClN4O/c22-17-8-4-7-15(9-17)18-13-25-26-20(18)16-10-19(23-12-16)21(27)24-11-14-5-2-1-3-6-14/h1-10,12-13,23H,11H2,(H,24,27)(H,25,26) PDJZASCRQRBYQS-UHFFFAOYSA-N 15621 N-Benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide::N-benzyl-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 5g::erk000092 Mitogen-activated protein kinase 10 Homo sapiens 550 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15621&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 33A 2OK1,2OJI 23647154 46515912 DB07010 ZINC20149027 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28547 CN(Cc1ccccc1)C(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1 InChI=1S/C22H19ClN4O/c1-27(14-15-6-3-2-4-7-15)22(28)20-11-17(12-24-20)21-19(13-25-26-21)16-8-5-9-18(23)10-16/h2-13,24H,14H2,1H3,(H,25,26) HJHGABLTQYNEHT-UHFFFAOYSA-N 15624 N-Benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-N-methyl-1H-pyrrole-2-carboxamide::N-benzyl-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-methyl-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 5j Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15624&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647157 46515915 ZINC14959157 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28548 Fc1ccc(CNC(=O)c2cc(c[nH]2)-c2n[nH]cc2-c2cccc(Cl)c2)cc1F InChI=1S/C21H15ClF2N4O/c22-15-3-1-2-13(7-15)16-11-27-28-20(16)14-8-19(25-10-14)21(29)26-9-12-4-5-17(23)18(24)6-12/h1-8,10-11,25H,9H2,(H,26,29)(H,27,28) JNPMSEMUYZIVNF-UHFFFAOYSA-N 15625 4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[(3,4-difluorophenyl)methyl]-1H-pyrrole-2-carboxamide::N-(3,4-Difluorobenzyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 5k Mitogen-activated protein kinase 10 Homo sapiens 790 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15625&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647158 46515916 ZINC14959161 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28549 COc1ccc(CNC(=O)c2cc(c[nH]2)-c2n[nH]cc2-c2cccc(Cl)c2)cc1 InChI=1S/C22H19ClN4O2/c1-29-18-7-5-14(6-8-18)11-25-22(28)20-10-16(12-24-20)21-19(13-26-27-21)15-3-2-4-17(23)9-15/h2-10,12-13,24H,11H2,1H3,(H,25,28)(H,26,27) KGJRXQASMIVWCI-UHFFFAOYSA-N 15626 4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[(4-methoxyphenyl)methyl]-1H-pyrrole-2-carboxamide::N-(4-Methoxybenzyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 5l Mitogen-activated protein kinase 10 Homo sapiens 840 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647159 46515917 ZINC14959165 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28550 Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)N1CCc2ccccc2C1 InChI=1S/C23H19ClN4O/c24-19-7-3-6-16(10-19)20-13-26-27-22(20)18-11-21(25-12-18)23(29)28-9-8-15-4-1-2-5-17(15)14-28/h1-7,10-13,25H,8-9,14H2,(H,26,27) MWATXBYHLNDFKU-UHFFFAOYSA-N 15627 2-({4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrol-2-yl}carbonyl)-1,2,3,4-tetrahydroisoquinoline::4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrol-2-yl)(3,4-dihydroisoquinolin-2-(1H)-yl)methane::Pyrrole Carboxamide Analog 5m Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647160 46515918 ZINC14959169 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28551 Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)NCCc1cccnc1 InChI=1S/C21H18ClN5O/c22-17-5-1-4-15(9-17)18-13-26-27-20(18)16-10-19(25-12-16)21(28)24-8-6-14-3-2-7-23-11-14/h1-5,7,9-13,25H,6,8H2,(H,24,28)(H,26,27) QDUDWHMLOOZLSL-UHFFFAOYSA-N 15628 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(2-(pyridin-3-yl)-ethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[2-(pyridin-3-yl)ethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 5n Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15628&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647161 46515919 ZINC14959173 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28552 Clc1cccc(c1)-c1c[nH]nc1-c1c[nH]c(c1)C(=O)NOCc1ccccc1 InChI=1S/C21H17ClN4O2/c22-17-8-4-7-15(9-17)18-12-24-25-20(18)16-10-19(23-11-16)21(27)26-28-13-14-5-2-1-3-6-14/h1-12,23H,13H2,(H,24,25)(H,26,27) CVYVCWOKSDKRHQ-UHFFFAOYSA-N 15629 N-(Benzyloxy)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1Hpyrrole-2-carboxamide::N-(benzyloxy)-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 5o Mitogen-activated protein kinase 10 Homo sapiens 2900 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15629&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647162 46515920 ZINC14959177 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28553 C[C@@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1 InChI=1S/C22H19ClN4O/c1-14(15-6-3-2-4-7-15)26-22(28)20-11-17(12-24-20)21-19(13-25-27-21)16-8-5-9-18(23)10-16/h2-14,24H,1H3,(H,25,27)(H,26,28)/t14-/m1/s1 DRCOMKWKOTTZJP-CQSZACIVSA-N 15630 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-((R)-1-phenylethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[(1R)-1-phenylethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6a Mitogen-activated protein kinase 10 Homo sapiens 3100 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15630&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647163 46515921 ZINC14959182 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28554 C[C@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1 InChI=1S/C22H19ClN4O/c1-14(15-6-3-2-4-7-15)26-22(28)20-11-17(12-24-20)21-19(13-25-27-21)16-8-5-9-18(23)10-16/h2-14,24H,1H3,(H,25,27)(H,26,28)/t14-/m0/s1 DRCOMKWKOTTZJP-AWEZNQCLSA-N 15631 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-((S)-1-phenylethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[(1S)-1-phenylethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6b Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15631&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647164 46515922 ZINC14959186 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28555 OC[C@@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1 InChI=1S/C22H19ClN4O2/c23-17-8-4-7-15(9-17)18-12-25-27-21(18)16-10-19(24-11-16)22(29)26-20(13-28)14-5-2-1-3-6-14/h1-12,20,24,28H,13H2,(H,25,27)(H,26,29)/t20-/m1/s1 BZOFGUPPOMCQER-HXUWFJFHSA-N 15632 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-((S)-2-hydroxy-1-phenylethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6c Mitogen-activated protein kinase 10 Homo sapiens 2800 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647165 46515923 ZINC14959189 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28556 OC(=O)[C@@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1 InChI=1S/C22H17ClN4O3/c23-16-8-4-7-14(9-16)17-12-25-27-19(17)15-10-18(24-11-15)21(28)26-20(22(29)30)13-5-2-1-3-6-13/h1-12,20,24H,(H,25,27)(H,26,28)(H,29,30)/t20-/m0/s1 UMZHRFFXXGXJSJ-FQEVSTJZSA-N 15633 (2S)-2-({4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrol-2-yl}formamido)-2-phenylacetic acid::(S)-2-(4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamido)-2-phenylacetic acid::Pyrrole Carboxamide Analog 6d Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647166 46515924 ZINC14959193 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28557 NC(=O)[C@@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1 InChI=1S/C22H18ClN5O2/c23-16-8-4-7-14(9-16)17-12-26-28-19(17)15-10-18(25-11-15)22(30)27-20(21(24)29)13-5-2-1-3-6-13/h1-12,20,25H,(H2,24,29)(H,26,28)(H,27,30)/t20-/m0/s1 BCUUZFIFKKWEHW-FQEVSTJZSA-N 15634 (2S)-2-({4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrol-2-yl}formamido)-2-phenylacetamide::N-((S)-Carbamoyl(phenyl)methyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6e Mitogen-activated protein kinase 10 Homo sapiens 3300 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15634&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647167 46515925 ZINC14959198 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28558 CNC(=O)[C@@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1 InChI=1S/C23H20ClN5O2/c1-25-23(31)21(14-6-3-2-4-7-14)28-22(30)19-11-16(12-26-19)20-18(13-27-29-20)15-8-5-9-17(24)10-15/h2-13,21,26H,1H3,(H,25,31)(H,27,29)(H,28,30)/t21-/m0/s1 HRQBKMJXRJHEMV-NRFANRHFSA-N 15635 (2S)-2-({4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrol-2-yl}formamido)-N-methyl-2-phenylacetamide::N-((S)-(Methylcarbamoyl(phenyl)methyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6f Mitogen-activated protein kinase 10 Homo sapiens 3900 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15635&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647168 46515926 ZINC14959202 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28559 OC1Cc2ccccc2C1NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1 InChI=1S/C23H19ClN4O2/c24-16-6-3-5-13(8-16)18-12-26-28-21(18)15-9-19(25-11-15)23(30)27-22-17-7-2-1-4-14(17)10-20(22)29/h1-9,11-12,20,22,25,29H,10H2,(H,26,28)(H,27,30) HJULFTQEKBTIGR-UHFFFAOYSA-N 15636 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-(2-hydroxy-2,3-dihydro-1H-inden-1-yl)-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6g Mitogen-activated protein kinase 10 Homo sapiens 3200 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647169 46515927 ZINC14959218 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28560 OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccc(F)cc1 InChI=1S/C22H18ClFN4O2/c23-16-3-1-2-14(8-16)18-11-26-28-21(18)15-9-19(25-10-15)22(30)27-20(12-29)13-4-6-17(24)7-5-13/h1-11,20,25,29H,12H2,(H,26,28)(H,27,30) CHRQOFCKHUIEES-UHFFFAOYSA-N 15637 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(1-(4-fluorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[1-(4-fluorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6h Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15637&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647170 46515928 ZINC14959224 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28561 OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccc(Cl)cc1 InChI=1S/C22H18Cl2N4O2/c23-16-6-4-13(5-7-16)20(12-29)27-22(30)19-9-15(10-25-19)21-18(11-26-28-21)14-2-1-3-17(24)8-14/h1-11,20,25,29H,12H2,(H,26,28)(H,27,30) IBZYAAWMHJTHPC-UHFFFAOYSA-N 15638 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(1-(4-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[1-(4-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6i Mitogen-activated protein kinase 10 Homo sapiens 2500 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15638&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647171 46515929 ZINC14959232 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28562 OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccc(cc1)C(F)(F)F InChI=1S/C23H18ClF3N4O2/c24-17-3-1-2-14(8-17)18-11-29-31-21(18)15-9-19(28-10-15)22(33)30-20(12-32)13-4-6-16(7-5-13)23(25,26)27/h1-11,20,28,32H,12H2,(H,29,31)(H,30,33) ULBBMFAYNFDAKN-UHFFFAOYSA-N 15639 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(1-(4-(trifluoro-methyl)phenyl)-2-hydroxy-ethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-{2-hydroxy-1-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6j Mitogen-activated protein kinase 10 Homo sapiens 2700 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15639&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647172 46515930 ZINC14959240 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28563 OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccccc1F InChI=1S/C22H18ClFN4O2/c23-15-5-3-4-13(8-15)17-11-26-28-21(17)14-9-19(25-10-14)22(30)27-20(12-29)16-6-1-2-7-18(16)24/h1-11,20,25,29H,12H2,(H,26,28)(H,27,30) XUVQHPRTXRLLPM-UHFFFAOYSA-N 15640 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(1-(2-fluorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[1-(2-fluorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6k Mitogen-activated protein kinase 10 Homo sapiens 3100 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15640&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647173 46515931 ZINC14959249 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28564 OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1cccc(F)c1 InChI=1S/C22H18ClFN4O2/c23-16-5-1-3-13(7-16)18-11-26-28-21(18)15-9-19(25-10-15)22(30)27-20(12-29)14-4-2-6-17(24)8-14/h1-11,20,25,29H,12H2,(H,26,28)(H,27,30) MHZXYMWATGIBPO-UHFFFAOYSA-N 15641 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(1-(3-fluorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[1-(3-fluorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6l Mitogen-activated protein kinase 10 Homo sapiens 3000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15641&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647174 46515932 ZINC14959259 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28565 OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccc(F)c(F)c1 InChI=1S/C22H17ClF2N4O2/c23-15-3-1-2-12(6-15)16-10-27-29-21(16)14-8-19(26-9-14)22(31)28-20(11-30)13-4-5-17(24)18(25)7-13/h1-10,20,26,30H,11H2,(H,27,29)(H,28,31) UAVINMGWYRSLQG-UHFFFAOYSA-N 15642 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(1-(3,4-difluorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[1-(3,4-difluorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6m Mitogen-activated protein kinase 10 Homo sapiens 2800 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15642&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647175 46515933 ZINC14959267 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28566 OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1cc(Cl)cc(Cl)c1 InChI=1S/C22H17Cl3N4O2/c23-15-3-1-2-12(4-15)18-10-27-29-21(18)14-7-19(26-9-14)22(31)28-20(11-30)13-5-16(24)8-17(25)6-13/h1-10,20,26,30H,11H2,(H,27,29)(H,28,31) HJTVLIXBOOZJMZ-UHFFFAOYSA-N 15643 4-(4-(3-Chlorophenyl)-1H-pyrazol-3-yl)-N-(1-(3,5-dichlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide::4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-N-[1-(3,5-dichlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6n Mitogen-activated protein kinase 10 Homo sapiens 3400 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15643&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647176 46515934 ZINC14959275 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28567 OC[C@@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccc(F)c(Cl)c1 InChI=1S/C22H17Cl2FN4O2/c23-15-3-1-2-12(6-15)16-10-27-29-21(16)14-8-19(26-9-14)22(31)28-20(11-30)13-4-5-18(25)17(24)7-13/h1-10,20,26,30H,11H2,(H,27,29)(H,28,31)/t20-/m1/s1 YMUYGRBBEDYUOP-HXUWFJFHSA-N 15645 N-((S)-1-(3-Chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide::N-[(1S)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6p Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15645&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 82A 2OJJ 15942697 46515936 DB07264 ZINC20149028 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28568 OC[C@H](NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccc(F)c(Cl)c1 InChI=1S/C22H17Cl2FN4O2/c23-15-3-1-2-12(6-15)16-10-27-29-21(16)14-8-19(26-9-14)22(31)28-20(11-30)13-4-5-18(25)17(24)7-13/h1-10,20,26,30H,11H2,(H,27,29)(H,28,31)/t20-/m0/s1 YMUYGRBBEDYUOP-FQEVSTJZSA-N 15646 N-((R)-1-(3-Chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide::N-[(1R)-1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide::Pyrrole Carboxamide Analog 6q Mitogen-activated protein kinase 10 Homo sapiens >4000 Curated from the literature by BindingDB 10.1021/jm061381f 10.7270/Q2BR8QFV 17300186 aid1797408 Aronov, AM; Baker, C; Bemis, GW; Cao, J; Chen, G; Ford, PJ; Germann, UA; Green, J; Hale, MR; Jacobs, M; Janetka, JW; Maltais, F; Martinez-Botella, G; Namchuk, MN; Straub, J; Tang, Q; Xie, X Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15646&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23647178 46515937 ZINC14959283 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28969 CCOc1nc(NC(C)=O)cc(N)c1C#N InChI=1S/C10H12N4O2/c1-3-16-10-7(5-11)8(12)4-9(14-10)13-6(2)15/h4H,3H2,1-2H3,(H3,12,13,14,15) DXAJWOOLPAIVJG-UHFFFAOYSA-N 15907 Aminopyridine-Based Inhibitor 6a::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide::aminopyridine deriv. 1 Mitogen-activated protein kinase 10 Homo sapiens 520 Curated from the literature by BindingDB 10.1021/jm060199b 10.7270/Q2P26WDX 16759099 aid1797445 Szczepankiewicz, BG; Kosogof, C; Nelson, LT; Liu, G; Liu, B; Zhao, H; Serby, MD; Xin, Z; Liu, M; Gum, RJ; Haasch, DL; Wang, S; Clampit, JE; Johnson, EF; Lubben, TH; Stashko, MA; Olejniczak, ET; Sun, C; Dorwin, SA; Haskins, K; Abad-Zapatero, C; Fry, EH; Hutchins, CW; Sham, HL; Rondinone, CM; Trevillyan, JM Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15907&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11715520 46516178 ZINC14959957 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28972 CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23) KQMPRSZTUSSXND-UHFFFAOYSA-N 15908 Aminopyridine-Based Inhibitor 6o::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide::aminopyridine deriv. 2 Mitogen-activated protein kinase 10 Homo sapiens 52 Curated from the literature by BindingDB 10.1021/jm060199b 10.7270/Q2P26WDX 16759099 aid1797445 Szczepankiewicz, BG; Kosogof, C; Nelson, LT; Liu, G; Liu, B; Zhao, H; Serby, MD; Xin, Z; Liu, M; Gum, RJ; Haasch, DL; Wang, S; Clampit, JE; Johnson, EF; Lubben, TH; Stashko, MA; Olejniczak, ET; Sun, C; Dorwin, SA; Haskins, K; Abad-Zapatero, C; Fry, EH; Hutchins, CW; Sham, HL; Rondinone, CM; Trevillyan, JM Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15908&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11624601 46516179 5998 ZINC14959960 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 28990 CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1C#N InChI=1S/C19H22N4O6S/c1-5-29-19-12(10-20)13(21)8-17(23-19)22-18(24)7-11-6-15(28-3)16(30(4,25)26)9-14(11)27-2/h6,8-9H,5,7H2,1-4H3,(H3,21,22,23,24) UIRLFLOVKAOFEX-UHFFFAOYSA-N 15939 Aminopyridine-Based Inhibitor 6s::N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 72 Curated from the literature by BindingDB 10.1021/jm060199b 10.7270/Q2P26WDX 16759099 aid1797445 Szczepankiewicz, BG; Kosogof, C; Nelson, LT; Liu, G; Liu, B; Zhao, H; Serby, MD; Xin, Z; Liu, M; Gum, RJ; Haasch, DL; Wang, S; Clampit, JE; Johnson, EF; Lubben, TH; Stashko, MA; Olejniczak, ET; Sun, C; Dorwin, SA; Haskins, K; Abad-Zapatero, C; Fry, EH; Hutchins, CW; Sham, HL; Rondinone, CM; Trevillyan, JM Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15939&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11539329 46516210 ZINC14960076 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 29008 COc1cc(c(OC)cc1CC(=O)Nc1cc(N)c(C#N)c(OC(C)C)n1)S(C)(=O)=O InChI=1S/C20H24N4O6S/c1-11(2)30-20-13(10-21)14(22)8-18(24-20)23-19(25)7-12-6-16(29-4)17(31(5,26)27)9-15(12)28-3/h6,8-9,11H,7H2,1-5H3,(H3,22,23,24,25) CSDDCHPGQGWRLI-UHFFFAOYSA-N 15956 Aminopyridine-Based Inhibitor 18b::N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide::N-[4-amino-5-cyano-6-(propan-2-yloxy)pyridin-2-yl]-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 18 Curated from the literature by BindingDB 10.1021/jm060199b 10.7270/Q2P26WDX 16759099 aid1797445 Szczepankiewicz, BG; Kosogof, C; Nelson, LT; Liu, G; Liu, B; Zhao, H; Serby, MD; Xin, Z; Liu, M; Gum, RJ; Haasch, DL; Wang, S; Clampit, JE; Johnson, EF; Lubben, TH; Stashko, MA; Olejniczak, ET; Sun, C; Dorwin, SA; Haskins, K; Abad-Zapatero, C; Fry, EH; Hutchins, CW; Sham, HL; Rondinone, CM; Trevillyan, JM Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15956&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11640926 46516226 ZINC14960142 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 29022 CC(=O)Nc1cc(N)c(C#N)c(n1)-c1ccccc1 InChI=1S/C14H12N4O/c1-9(19)17-13-7-12(16)11(8-15)14(18-13)10-5-3-2-4-6-10/h2-7H,1H3,(H3,16,17,18,19) GTMGQYXCPKUZAD-UHFFFAOYSA-N 15968 Aminopyridine-Based Inhibitor 24::N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 3300 Curated from the literature by BindingDB 10.1021/jm060199b 10.7270/Q2P26WDX 16759099 aid1797445 Szczepankiewicz, BG; Kosogof, C; Nelson, LT; Liu, G; Liu, B; Zhao, H; Serby, MD; Xin, Z; Liu, M; Gum, RJ; Haasch, DL; Wang, S; Clampit, JE; Johnson, EF; Lubben, TH; Stashko, MA; Olejniczak, ET; Sun, C; Dorwin, SA; Haskins, K; Abad-Zapatero, C; Fry, EH; Hutchins, CW; Sham, HL; Rondinone, CM; Trevillyan, JM Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15968&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11658882 46516237 ZINC14960195 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 29025 CCOc1nc(NC(=O)Cc2cc(OC)c(cc2OC)S(C)(=O)=O)cc(N)c1Cl InChI=1S/C18H22ClN3O6S/c1-5-28-18-17(19)11(20)8-15(22-18)21-16(23)7-10-6-13(27-3)14(29(4,24)25)9-12(10)26-2/h6,8-9H,5,7H2,1-4H3,(H3,20,21,22,23) JUKUQWGWZSESAV-UHFFFAOYSA-N 15976 Aminopyridine-Based Inhibitor 35::N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methane-sulfonyl-2,5-dimethoxyphenyl)acetamide::N-(4-amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 61 Curated from the literature by BindingDB 10.1021/jm060199b 10.7270/Q2P26WDX 16759099 aid1797445 Szczepankiewicz, BG; Kosogof, C; Nelson, LT; Liu, G; Liu, B; Zhao, H; Serby, MD; Xin, Z; Liu, M; Gum, RJ; Haasch, DL; Wang, S; Clampit, JE; Johnson, EF; Lubben, TH; Stashko, MA; Olejniczak, ET; Sun, C; Dorwin, SA; Haskins, K; Abad-Zapatero, C; Fry, EH; Hutchins, CW; Sham, HL; Rondinone, CM; Trevillyan, JM Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15976&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11590363 46516245 ZINC14960220 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 29064 CCCn1c(nc(c1-c1ccnc(NC2CC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCN(C)CC1 InChI=1S/C25H30Cl2N6/c1-3-12-33-23(21-8-11-28-25(30-21)29-18-5-6-18)22(17-4-7-19(26)20(27)15-17)31-24(33)16-9-13-32(2)14-10-16/h4,7-8,11,15-16,18H,3,5-6,9-10,12-14H2,1-2H3,(H,28,29,30) XCTKFTOEAKJMII-UHFFFAOYSA-N 16015 CHEMBL252967::N-cyclopropyl-4-[4-(3,4-dichlorophenyl)-2-(1-methylpiperidin-4-yl)-1-propyl-1H-imidazol-5-yl]pyrimidin-2-amine::imidazole-pyrimidine compound 1 Mitogen-activated protein kinase 10 Homo sapiens 7.1 7 22.00 C Curated from the literature by BindingDB 10.1016/S1074-5521(03)00159-5 10.7270/Q2DJ5CWZ 12954329 aid1797457 Scapin, G; Patel, SB; Lisnock, J; Becker, JW; LoGrasso, PV Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16015&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 984 1PMN 447872 46516284 CHEMBL252967 DB03084 ZINC12153007 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 29065 CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1 InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33) UQFRSHRWRKYNDE-UHFFFAOYSA-N 16016 CHEMBL437747::N-cyclohexyl-4-[4-(3,4-dichlorophenyl)-2-(piperidin-4-yl)-1-propyl-1H-imidazol-5-yl]pyrimidin-2-amine::N-cyclohexyl-4-[4-(3,4-dichlorophenyl)-2-piperidin-4-yl-1-propyl-1H-imidazol-5-yl]pyrimidin-2-amine::imidazole-pyrimidine compound 2 Mitogen-activated protein kinase 10 Homo sapiens 1.6 7 22.00 C Curated from the literature by BindingDB 10.1016/S1074-5521(03)00159-5 10.7270/Q2DJ5CWZ 12954329 aid1797457 Scapin, G; Patel, SB; Lisnock, J; Becker, JW; LoGrasso, PV Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16016&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 880 4Z9L 447873 46516285 CHEMBL437747 DB02388 ZINC12501995 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 29066 Oc1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C18H12N2O/c21-15-4-1-12(2-5-15)14-9-16-17-11-19-8-7-13(17)3-6-18(16)20-10-14/h1-11,21H IUSSGTWHFMSCOY-UHFFFAOYSA-N 16017 4-(2,7-phenanthrolin-9-yl)phenol::4-(2=7-phenantrolin-9-yl)phenol::CHEMBL248643::phenantroline compound 3 Mitogen-activated protein kinase 10 Homo sapiens 590 7 22.00 C Curated from the literature by BindingDB 10.1016/S1074-5521(03)00159-5 10.7270/Q2DJ5CWZ 12954329 aid1797457 Scapin, G; Patel, SB; Lisnock, J; Becker, JW; LoGrasso, PV Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16017&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9HP 1PMU 5326727 46516286 CHEMBL248643 DB03623 ZINC02047421 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 29067 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 150 7 22.00 C Curated from the literature by BindingDB 10.1016/S1074-5521(03)00159-5 10.7270/Q2DJ5CWZ 12954329 aid1797457 Scapin, G; Patel, SB; Lisnock, J; Becker, JW; LoGrasso, PV Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 31856 COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(OCCCN4CCN(C)CC4)c(OC)c3)n2)c(OC)c1 InChI=1S/C37H46N6O7/c1-25-10-8-11-26(2)34(25)50-37(44)43(29-13-12-28(45-4)24-30(29)46-5)33-14-15-38-36(40-33)39-27-22-31(47-6)35(32(23-27)48-7)49-21-9-16-42-19-17-41(3)18-20-42/h8,10-15,22-24H,9,16-21H2,1-7H3,(H,38,39,40) VSJXTUFWPAOYLC-UHFFFAOYSA-N 17744 2,6-dimethylphenyl N-[2-({3,5-dimethoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]phenyl}amino)pyrimidin-4-yl]-N-(2,4-dimethoxyphenyl)carbamate::2-aminopyrimidine carbamate, 43 Mitogen-activated protein kinase 10 Homo sapiens >5000 Curated from the literature by BindingDB 10.1021/jm060435i 10.7270/Q2SB440C 16884310 aid1797647 Martin, MW; Newcomb, J; Nunes, JJ; McGowan, DC; Armistead, DM; Boucher, C; Buchanan, JL; Buckner, W; Chai, L; Elbaum, D; Epstein, LF; Faust, T; Flynn, S; Gallant, P; Gore, A; Gu, Y; Hsieh, F; Huang, X; Lee, JH; Metz, D; Middleton, S; Mohn, D; Morgenstern, K; Morrison, MJ; Novak, PM; Oliveira-dos-Santos, A; Powers, D; Rose, P; Schneider, S; Sell, S; Tudor, Y; Turci, SM; Welcher, AA; White, RD; Zack, D; Zhao, H; Zhu, L; Zhu, X; Ghiron, C; Amouzegh, P; Ermann, M; Jenkins, J; Johnston, D; Napier, S; Power, E Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17744&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1N9 2OFU 11843159 46517902 ZINC24815575 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 47229 Cc1ccc(O)cc1Nc1ccnc2cc(ccc12)-c1csc(C=O)n1 InChI=1S/C20H15N3O2S/c1-12-2-4-14(25)9-17(12)22-16-6-7-21-18-8-13(3-5-15(16)18)19-11-26-20(10-24)23-19/h2-11,25H,1H3,(H,21,22) VKQPTVJDZIILPG-UHFFFAOYSA-N 25191 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde::7-substituted 4-anilinoquinoline, 31::BMCL174363 Compound 1::BMCL18318 Compound 1 Mitogen-activated protein kinase 10 Homo sapiens >4000 >16000 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.10.076 10.7270/Q2KP80G3 18006306 aid1798617 Angell, RM; Bamborough, P; Cleasby, A; Cockerill, SG; Jones, KL; Mooney, CJ; Somers, DO; Walker, AL GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25191&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search GK1 2ZAZ 23644582 56374332 DB07832 ZINC16052770 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 47230 COc1ccc(NC(=O)c2ccc(cc2)-c2cc(ccc2C)-c2nnc(C)o2)cc1N1CCN(C)CC1 InChI=1S/C29H31N5O3/c1-19-5-6-23(29-32-31-20(2)37-29)17-25(19)21-7-9-22(10-8-21)28(35)30-24-11-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,30,35) KPNDZYJBDZIKBN-UHFFFAOYSA-N 25979 BMCL18324 Compound 1::N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide::biphenyl amide, 2 Mitogen-activated protein kinase 10 Homo sapiens >4000 >16000 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.10.076 10.7270/Q2KP80G3 18006306 aid1798617 Angell, RM; Bamborough, P; Cleasby, A; Cockerill, SG; Jones, KL; Mooney, CJ; Somers, DO; Walker, AL GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25979&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 19007057 56413267 ZINC03789683 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 47231 Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)Nc1cccc(c1)C#N InChI=1S/C24H18N4O2/c1-15-6-7-20(24-28-27-16(2)30-24)13-22(15)18-8-10-19(11-9-18)23(29)26-21-5-3-4-17(12-21)14-25/h3-13H,1-2H3,(H,26,29) PMMLSQFPBFKLHH-UHFFFAOYSA-N 25980 BMCL18324 Compound 3::CHEMBL270164::N-(3-cyanophenyl)-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide::biphenyl amide, 3 Mitogen-activated protein kinase 10 Homo sapiens >4000 >16000 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.10.076 10.7270/Q2KP80G3 18006306 aid1798617 Angell, RM; Bamborough, P; Cleasby, A; Cockerill, SG; Jones, KL; Mooney, CJ; Somers, DO; Walker, AL GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25980&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search GK3 2ZB0 10200651 56413268 CHEMBL270164 DB07833 ZINC29130381 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 47232 Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1 InChI=1S/C21H21N3O2/c1-13-3-6-18(21-24-23-14(2)26-21)11-19(13)16-7-9-17(10-8-16)20(25)22-12-15-4-5-15/h3,6-11,15H,4-5,12H2,1-2H3,(H,22,25) FOHZGCHKLPIBBX-UHFFFAOYSA-N 25981 BMCL18324 Compound 17::CHEMBL273158::D3RKN_78::N-(cyclopropylmethyl)-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide::biphenyl amide, 4 Mitogen-activated protein kinase 10 Homo sapiens >4000 >16000 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2007.10.076 10.7270/Q2KP80G3 18006306 aid1798617 Angell, RM; Bamborough, P; Cleasby, A; Cockerill, SG; Jones, KL; Mooney, CJ; Somers, DO; Walker, AL GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25981&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search GK4 2ZB1 21078798 56413269 CHEMBL273158 DB07834 ZINC16052768 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50796 COc1cc(ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C InChI=1S/C27H31FN8O2/c1-16(2)35-11-13-36(14-12-35)17-7-8-20(22(15-17)38-3)32-27-33-25-18(9-10-30-25)26(34-27)31-21-6-4-5-19(28)23(21)24(29)37/h4-10,15-16H,11-14H2,1-3H3,(H2,29,37)(H3,30,31,32,33,34) HXZDICYKFAOZLE-UHFFFAOYSA-N 27783 2-fluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide::BMCL19469 Compound 13::CHEMBL507625::pyrrolo[2,3-d]pyrimidine deriv., 1 Mitogen-activated protein kinase 10 Homo sapiens 100 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.077 10.7270/Q2NZ85ZT 19071018 aid1798834 Chamberlain, SD; Redman, AM; Wilson, JW; Deanda, F; Shotwell, JB; Gerding, R; Lei, H; Yang, B; Stevens, KL; Hassell, AM; Shewchuk, LM; Leesnitzer, MA; Smith, JL; Sabbatini, P; Atkins, C; Groy, A; Rowand, JL; Kumar, R; Mook, RA; Moorthy, G; Patnaik, S GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27783&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search GS3 3EKN 25113170 57560296 CHEMBL507625 ZINC53186795 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50797 COc1ccc(cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C InChI=1S/C27H31FN8O2/c1-16(2)35-11-13-36(14-12-35)17-7-8-22(38-3)21(15-17)32-27-33-25-18(9-10-30-25)26(34-27)31-20-6-4-5-19(28)23(20)24(29)37/h4-10,15-16H,11-14H2,1-3H3,(H2,29,37)(H3,30,31,32,33,34) FIJVJJGBQDYFNS-UHFFFAOYSA-N 27784 2-fluoro-6-{[2-({2-methoxy-5-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide::BMCL19469 Compound 22::pyrrolo[2,3-d]pyrimidine deriv., 2 Mitogen-activated protein kinase 10 Homo sapiens 5011 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.077 10.7270/Q2NZ85ZT 19071018 aid1798834 Chamberlain, SD; Redman, AM; Wilson, JW; Deanda, F; Shotwell, JB; Gerding, R; Lei, H; Yang, B; Stevens, KL; Hassell, AM; Shewchuk, LM; Leesnitzer, MA; Smith, JL; Sabbatini, P; Atkins, C; Groy, A; Rowand, JL; Kumar, R; Mook, RA; Moorthy, G; Patnaik, S GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27784&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25218564 57560297 ZINC40873243 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50798 COc1cc(C)c(cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C InChI=1S/C28H33FN8O2/c1-16(2)36-10-12-37(13-11-36)22-15-21(23(39-4)14-17(22)3)33-28-34-26-18(8-9-31-26)27(35-28)32-20-7-5-6-19(29)24(20)25(30)38/h5-9,14-16H,10-13H2,1-4H3,(H2,30,38)(H3,31,32,33,34,35) FUOIPYSAZWJAPO-UHFFFAOYSA-N 27785 2-fluoro-6-{[2-({2-methoxy-4-methyl-5-[4-(propan-2-yl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide::BMCL19469 Compound 23::pyrrolo[2,3-d]pyrimidine deriv., 3 Mitogen-activated protein kinase 10 Homo sapiens 6310 7.5 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.077 10.7270/Q2NZ85ZT 19071018 aid1798834 Chamberlain, SD; Redman, AM; Wilson, JW; Deanda, F; Shotwell, JB; Gerding, R; Lei, H; Yang, B; Stevens, KL; Hassell, AM; Shewchuk, LM; Leesnitzer, MA; Smith, JL; Sabbatini, P; Atkins, C; Groy, A; Rowand, JL; Kumar, R; Mook, RA; Moorthy, G; Patnaik, S GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27785&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25218565 57560298 ZINC53281565 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50819 CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) HZTYDQRUAWIZRE-UHFFFAOYSA-N 27817 2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40 Mitogen-activated protein kinase 10 Homo sapiens 2000 Curated from the literature by BindingDB 10.1016/j.bmcl.2008.11.077 10.7270/Q2NZ85ZT 19071018 aid1798834 Chamberlain, SD; Redman, AM; Wilson, JW; Deanda, F; Shotwell, JB; Gerding, R; Lei, H; Yang, B; Stevens, KL; Hassell, AM; Shewchuk, LM; Leesnitzer, MA; Smith, JL; Sabbatini, P; Atkins, C; Groy, A; Rowand, JL; Kumar, R; Mook, RA; Moorthy, G; Patnaik, S GSK http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25182616 57560329 5683 ZINC43202844 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66062 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Mitogen-activated protein kinase 10 Homo sapiens 760 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66063 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 10 Homo sapiens 110 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66064 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Mitogen-activated protein kinase 10 Homo sapiens 5500 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66065 CN1CCC([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12?,17-/m1/s1 BIIVYFLTOXDAOV-RGUGMKFQSA-N 31099 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S)-3-hydroxy-1-methyl-4-piperidinyl]-1-benzopyran-4-one::2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S)-3-hydroxy-1-methyl-4-piperidyl]chromone::2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one::2-(2-chlorophenyl)-8-[(3S)-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one::CHEMBL45741::Flavopiridol::cid_24867231 Mitogen-activated protein kinase 10 Homo sapiens 5500 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31099&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3BLR,1C8K,1E1Y 24867231 252615340 CHEMBL45741 ZINC29416077 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66066 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Mitogen-activated protein kinase 10 Homo sapiens 1900 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66067 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Mitogen-activated protein kinase 10 Homo sapiens 3200 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66068 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Mitogen-activated protein kinase 10 Homo sapiens 3100 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search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itogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66069 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Mitogen-activated protein kinase 10 Homo sapiens 1300 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66070 CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m0/s1 BMGQWWVMWDBQGC-PZFYLCKJSA-N 31094 PKC-412::cid_24202429 Mitogen-activated protein kinase 10 Homo sapiens 3600 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31094&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24202429 242052840 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66071 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Mitogen-activated protein kinase 10 Homo sapiens 42 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66072 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 10 Homo sapiens 35 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66073 CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1 HKSZLNNOFSGOKW-HMWZOHBLSA-N 31096 CHEMBL290084::Staurosporine::cid_451705 Mitogen-activated protein kinase 10 Homo sapiens 110 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31096&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 451705 242052841 CHEMBL290084 346 ZINC05615681 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 66074 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Mitogen-activated protein kinase 10 Homo sapiens 2800 PubChem 10.7270/Q26T0K0S aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79529 Cc1nc2sccn2c1-c1csc(Nc2cc(C)ccn2)n1 InChI=1S/C15H13N5S2/c1-9-3-4-16-12(7-9)19-14-18-11(8-22-14)13-10(2)17-15-20(13)5-6-21-15/h3-8H,1-2H3,(H,16,18,19) IFAWIELOCTZGNZ-UHFFFAOYSA-N 32259 4-(6-methyl-5-imidazo[2,1-b]thiazolyl)-N-(4-methyl-2-pyridinyl)-2-thiazolamine::4-(6-methylimidazo[2,1-b][1,3]thiazol-5-yl)-N-(4-methylpyridin-2-yl)-1,3-thiazol-2-amine::MLS000034327::SMR000010233::[4-(6-Methyl-imidazo[2,1-b]thiazol-5-yl)-thiazol-2-yl]-(4-methyl-pyridin-2-yl)-amine::[4-(6-methylimidazo[2,1-b]thiazol-5-yl)thiazol-2-yl]-(4-methyl-2-pyridyl)amine::cid_644740 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32259&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 644740 252615705 ZINC04135704 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79530 C1Cc2c([nH]c3ccccc23)-c2n[nH]cc12 InChI=1S/C13H11N3/c1-2-4-11-9(3-1)10-6-5-8-7-14-16-12(8)13(10)15-11/h1-4,7,15H,5-6H2,(H,14,16) WQSHEPAFFTVLAP-UHFFFAOYSA-N 24713 1,2,4,5-tetrahydropyrazolo[3,4-a]carbazole::3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]hexadeca-1(9),2,5,10,12,14-hexaene::Tetrahydropyrazolo[3,4-a]carbazole, 19 Mitogen-activated protein kinase 10 Homo sapiens 20610 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24713&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5406463 56269664 ZINC96308815 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79531 COc1cccc2c(O)c(cnc12)C(=O)NCc1cccs1 InChI=1S/C16H14N2O3S/c1-21-13-6-2-5-11-14(13)17-9-12(15(11)19)16(20)18-8-10-4-3-7-22-10/h2-7,9H,8H2,1H3,(H,17,19)(H,18,20) XIIVPABVOIFYAE-UHFFFAOYSA-N 39420 4-Hydroxy-8-methoxy-quinoline-3-carboxylic acid (thiophen-2-ylmethyl)-amide::4-keto-8-methoxy-N-(2-thenyl)-1H-quinoline-3-carboxamide::8-methoxy-4-oxidanylidene-N-(thiophen-2-ylmethyl)-1H-quinoline-3-carboxamide::8-methoxy-4-oxo-N-(thiophen-2-ylmethyl)-1H-quinoline-3-carboxamide::MLS000033055::SMR000006201::cid_645818 Mitogen-activated protein kinase 10 Homo sapiens 18900 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39420&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 645818 252620312 ZINC13116841 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79532 CC(=NCc1ccco1)c1c(C)[nH]n(-c2nc3ccccc3s2)c1=O InChI=1S/C18H16N4O2S/c1-11(19-10-13-6-5-9-24-13)16-12(2)21-22(17(16)23)18-20-14-7-3-4-8-15(14)25-18/h3-9,21H,10H2,1-2H3 VIZOFWYXVYFNTB-UHFFFAOYSA-N 38251 (4Z)-2-(1,3-benzothiazol-2-yl)-4-[1-(2-furanylmethylamino)ethylidene]-5-methyl-3-pyrazolone::(4Z)-2-(1,3-benzothiazol-2-yl)-4-[1-(2-furfurylamino)ethylidene]-5-methyl-2-pyrazolin-3-one::(4Z)-2-(1,3-benzothiazol-2-yl)-4-[1-(furan-2-ylmethylamino)ethylidene]-5-methyl-pyrazol-3-one::(4Z)-2-(1,3-benzothiazol-2-yl)-4-[1-(furan-2-ylmethylamino)ethylidene]-5-methylpyrazol-3-one::2-Benzothiazol-2-yl-4-{1-[(E)-furan-2-ylmethylimino]-ethyl}-5-methyl-1,2-dihydro-pyrazol-3-one::MLS000073450::SMR000011192::cid_5453475 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38251&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5453475 252619171 ZINC13739318 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79533 Fc1ccccc1N1CCN(CC1)C(=O)CSc1ncccc1-c1nc2ccccc2[nH]1 InChI=1S/C24H22FN5OS/c25-18-7-1-4-10-21(18)29-12-14-30(15-13-29)22(31)16-32-24-17(6-5-11-26-24)23-27-19-8-2-3-9-20(19)28-23/h1-11H,12-16H2,(H,27,28) DXMMERWCIYVDTK-UHFFFAOYSA-N 42576 2-[3-(1H-Benzoimidazol-2-yl)-pyridin-2-ylsulfanyl]-1-[4-(2-fluoro-phenyl)-piperazin-1-yl]-ethanone::2-[3-(1H-benzimidazol-2-yl)pyridin-2-yl]sulfanyl-1-[4-(2-fluorophenyl)piperazin-1-yl]ethanone::2-[[3-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]-1-[4-(2-fluorophenyl)-1-piperazinyl]ethanone::2-[[3-(1H-benzimidazol-2-yl)-2-pyridyl]thio]-1-[4-(2-fluorophenyl)piperazino]ethanone::MLS000033700::SMR000007839::cid_646144 Mitogen-activated protein kinase 10 Homo sapiens 55890 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42576&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 646144 252623270 ZINC01329451 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79534 CC1(C)Oc2ccc3ccc(=O)oc3c2-c2cn[nH]c12 InChI=1S/C15H12N2O3/c1-15(2)14-9(7-16-17-14)12-10(20-15)5-3-8-4-6-11(18)19-13(8)12/h3-7H,1-2H3,(H,16,17) JIWOOKVVUNWVMP-UHFFFAOYSA-N 39188 4,4-Dimethyl-3H,4H-5,11-dioxa-2,3-diaza-cyclopenta[c]phenanthren-10-one::MLS000028242::SMR000012236::cid_646236 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39188&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 646236 242052955 ZINC06530421 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79535 Cc1ccccc1-c1nnc(S)o1 InChI=1S/C9H8N2OS/c1-6-4-2-3-5-7(6)8-10-11-9(13)12-8/h2-5H,1H3,(H,11,13) HNFIJWNVPWXSOL-UHFFFAOYSA-N 42577 5-(2-methylphenyl)-3H-1,3,4-oxadiazole-2-thione::5-(o-tolyl)-3H-1,3,4-oxadiazole-2-thione::5-o-Tolyl-3H-[1,3,4]oxadiazole-2-thione::MLS000029608::SMR000009336::cid_774385 Mitogen-activated protein kinase 10 Homo sapiens 55500 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42577&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 774385 252623271 ZINC01510006 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79536 Brc1cnc2nc(CNC(=O)c3ccccc3)[nH]c2c1 InChI=1S/C14H11BrN4O/c15-10-6-11-13(16-7-10)19-12(18-11)8-17-14(20)9-4-2-1-3-5-9/h1-7H,8H2,(H,17,20)(H,16,18,19) QHNFYTLXAVVBSP-UHFFFAOYSA-N 42578 MLS000077388::N-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-ylmethyl)-benzamide::N-[(6-bromanyl-1H-imidazo[4,5-b]pyridin-2-yl)methyl]benzamide::N-[(6-bromo-1H-imidazo[4,5-b]pyridin-2-yl)methyl]benzamide::SMR000001052::cid_342996 Mitogen-activated protein kinase 10 Homo sapiens 38250 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42578&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 342996 252623272 ZINC06551248 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79537 COC(=O)c1ccccc1NC(=O)CN1CCN(CC1)C(=O)c1ccco1 InChI=1S/C19H21N3O5/c1-26-19(25)14-5-2-3-6-15(14)20-17(23)13-21-8-10-22(11-9-21)18(24)16-7-4-12-27-16/h2-7,12H,8-11,13H2,1H3,(H,20,23) TVVDBTNDTBPYCS-UHFFFAOYSA-N 42579 2-[[2-[4-(2-furoyl)piperazino]acetyl]amino]benzoic acid methyl ester::2-[[2-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-1-oxoethyl]amino]benzoic acid methyl ester::2-{2-[4-(Furan-2-carbonyl)-piperazin-1-yl]-acetylamino}-benzoic acid methyl ester::MLS000029996::SMR000005377::cid_647022::methyl 2-[2-[4-(furan-2-ylcarbonyl)piperazin-1-yl]ethanoylamino]benzoate::methyl 2-[[2-[4-(furan-2-carbonyl)piperazin-1-yl]acetyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 34500 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42579&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 647022 252623273 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79538 CCOc1cc(ccc1O)C1NC(=O)N=C(C)C1C(=O)OCc1ccccc1 InChI=1S/C21H22N2O5/c1-3-27-17-11-15(9-10-16(17)24)19-18(13(2)22-21(26)23-19)20(25)28-12-14-7-5-4-6-8-14/h4-11,18-19,24H,3,12H2,1-2H3,(H,23,26) RUMGUDLNKZKREJ-UHFFFAOYSA-N 42580 (phenylmethyl) 4-(3-ethoxy-4-oxidanyl-phenyl)-6-methyl-2-oxidanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate::4-(3-Ethoxy-4-hydroxy-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid benzyl ester::4-(3-ethoxy-4-hydroxy-phenyl)-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid benzyl ester::4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (phenylmethyl) ester::MLS000072769::SMR000011114::benzyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate::cid_647137 Mitogen-activated protein kinase 10 Homo sapiens 34630 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42580&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896537 252623274 ZINC00812899 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79539 COc1ccc(cc1)S(=O)(=O)N1CCC(CC1)n1cnc2cc(ccc12)C(F)(F)F InChI=1S/C20H20F3N3O3S/c1-29-16-3-5-17(6-4-16)30(27,28)25-10-8-15(9-11-25)26-13-24-18-12-14(20(21,22)23)2-7-19(18)26/h2-7,12-13,15H,8-11H2,1H3 HWJQMYWOBTZEDM-UHFFFAOYSA-N 42581 1-[1-(4-Methoxy-benzenesulfonyl)-piperidin-4-yl]-5-trifluoromethyl-1H-benzoimidazole::1-[1-(4-methoxyphenyl)sulfonyl-4-piperidinyl]-5-(trifluoromethyl)benzimidazole::1-[1-(4-methoxyphenyl)sulfonyl-4-piperidyl]-5-(trifluoromethyl)benzimidazole::1-[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]-5-(trifluoromethyl)benzimidazole::MLS000073899::SMR000006463::cid_647274 Mitogen-activated protein kinase 10 Homo sapiens 54610 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42581&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 647274 252623275 ZINC01380378 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79540 Fc1ccc2n(cnc2c1)C1CCN(CC1)S(=O)(=O)c1ccc2OCCOc2c1 InChI=1S/C20H20FN3O4S/c21-14-1-3-18-17(11-14)22-13-24(18)15-5-7-23(8-6-15)29(25,26)16-2-4-19-20(12-16)28-10-9-27-19/h1-4,11-13,15H,5-10H2 MXVWQEQAIWUYLQ-UHFFFAOYSA-N 42582 1-[1-(2,3-Dihydro-benzo[1,4]dioxine-6-sulfonyl)-piperidin-4-yl]-5-fluoro-1H-benzoimidazole::1-[1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-piperidinyl]-5-fluorobenzimidazole::1-[1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-piperidyl]-5-fluoro-benzimidazole::1-[1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperidin-4-yl]-5-fluoranyl-benzimidazole::1-[1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperidin-4-yl]-5-fluorobenzimidazole::MLS000074571::SMR000006452::cid_647280 Mitogen-activated protein kinase 10 Homo sapiens 49420 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42582&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 647280 252623276 ZINC01380333 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79541 Oc1cccc2c1sc1nc3CCCCCn3c(=O)c21 InChI=1S/C15H14N2O2S/c18-10-6-4-5-9-12-14(20-13(9)10)16-11-7-2-1-3-8-17(11)15(12)19/h4-6,18H,1-3,7-8H2 ROGKCGCLJPZITK-UHFFFAOYSA-N 42583 1-Hydroxy-7,8,9,10-tetrahydro-6H-12-thia-5a,11-diaza-cyclohepta[b]fluoren-5-one::MLS000074023::SMR000009844::cid_534281 Mitogen-activated protein kinase 10 Homo sapiens 55650 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42583&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 534281 242053027 ZINC00365807 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79542 Cc1ccc(cc1)S(=O)(=O)NCCCCCC(=O)Nc1nccs1 InChI=1S/C16H21N3O3S2/c1-13-6-8-14(9-7-13)24(21,22)18-10-4-2-3-5-15(20)19-16-17-11-12-23-16/h6-9,11-12,18H,2-5,10H2,1H3,(H,17,19,20) YRMXMJDXXJCTQG-UHFFFAOYSA-N 42584 6-(Toluene-4-sulfonylamino)-hexanoic acid thiazol-2-ylamide::6-[(4-methylphenyl)sulfonylamino]-N-(1,3-thiazol-2-yl)hexanamide::6-[(4-methylphenyl)sulfonylamino]-N-(2-thiazolyl)hexanamide::MLS000030596::N-thiazol-2-yl-6-(tosylamino)hexanamide::SMR000012744::cid_647437 Mitogen-activated protein kinase 10 Homo sapiens 45960 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42584&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 647437 252623277 ZINC04275635 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79543 CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccccc1 InChI=1S/C14H13N5O2/c1-3-19-12-10(13(20)18(2)14(21)16-12)15-11(17-19)9-7-5-4-6-8-9/h4-8H,3H2,1-2H3 HJXOIRIPJDWFBS-UHFFFAOYSA-N 31040 1-Ethyl-6-methyl-3-phenyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::1-ethyl-6-methyl-3-phenyl-pyrimido[5,4-e][1,2,4]triazine-5,7-dione::1-ethyl-6-methyl-3-phenyl-pyrimido[5,4-e][1,2,4]triazine-5,7-quinone::1-ethyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7-dione::MLS000027832::SMR000008919::US9073941, 602::cid_647501 Mitogen-activated protein kinase 10 Homo sapiens 36320 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31040&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 647501 252615292 ZINC00487873 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79544 COC(=O)c1cccc2C(N=O)c3ccccc3-c12 InChI=1S/C15H11NO3/c1-19-15(17)12-8-4-7-11-13(12)9-5-2-3-6-10(9)14(11)16-18/h2-8,14H,1H3 DAGAGKZBUIOZKE-UHFFFAOYSA-N 39195 (9Z)-9-hydroximinofluorene-4-carboxylic acid methyl ester::9-[(Z)-Hydroxyimino]-9H-fluorene-4-carboxylic acid methyl ester::9-hydroximinofluorene-4-carboxylic acid methyl ester::9-hydroxyimino-4-fluorenecarboxylic acid methyl ester::MLS000070237::SMR000009569::cid_6398908::methyl 9-hydroxyiminofluorene-4-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 8813 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39195&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91497757 252620093 ZINC12378336 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79545 CCCc1nc(SCC(=O)N2CCCC2)c2ccccc2n1 InChI=1S/C17H21N3OS/c1-2-7-15-18-14-9-4-3-8-13(14)17(19-15)22-12-16(21)20-10-5-6-11-20/h3-4,8-9H,2,5-7,10-12H2,1H3 JNFHBRYMDHBLQB-UHFFFAOYSA-N 42585 2-(2-Propyl-quinazolin-4-ylsulfanyl)-1-pyrrolidin-1-yl-ethanone::2-(2-propylquinazolin-4-yl)sulfanyl-1-pyrrolidin-1-yl-ethanone::2-(2-propylquinazolin-4-yl)sulfanyl-1-pyrrolidin-1-ylethanone::2-[(2-propyl-4-quinazolinyl)thio]-1-(1-pyrrolidinyl)ethanone::2-[(2-propylquinazolin-4-yl)thio]-1-pyrrolidino-ethanone::MLS000073776::SMR000006834::cid_648420 Mitogen-activated protein kinase 10 Homo sapiens 50440 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42585&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 648420 252623278 ZINC01342698 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79546 CCOC(=O)CCCc1sc(N)nc1-c1[nH]c(=O)[nH]c1C InChI=1S/C13H18N4O3S/c1-3-20-9(18)6-4-5-8-11(16-12(14)21-8)10-7(2)15-13(19)17-10/h3-6H2,1-2H3,(H2,14,16)(H2,15,17,19) KAKCYKAPMDKFCI-UHFFFAOYSA-N 42586 4-[2-Amino-4-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-thiazol-5-yl]-butyric acid ethyl ester::4-[2-amino-4-(2-keto-5-methyl-4-imidazolin-4-yl)thiazol-5-yl]butyric acid ethyl ester;hydrobromide::4-[2-amino-4-(5-methyl-2-oxo-1,3-dihydroimidazol-4-yl)-5-thiazolyl]butanoic acid ethyl ester;hydrobromide::MLS000030780::SMR000011427::cid_2871182::ethyl 4-[2-amino-4-(5-methyl-2-oxo-1,3-dihydroimidazol-4-yl)-1,3-thiazol-5-yl]butanoate;hydrobromide::ethyl 4-[2-azanyl-4-(5-methyl-2-oxidanylidene-1,3-dihydroimidazol-4-yl)-1,3-thiazol-5-yl]butanoate;hydrobromide Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42586&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 648756 252623279 ZINC02476741 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79547 COC(=O)c1ccccc1NC(=O)COC(=O)c1ccco1 InChI=1S/C15H13NO6/c1-20-14(18)10-5-2-3-6-11(10)16-13(17)9-22-15(19)12-7-4-8-21-12/h2-8H,9H2,1H3,(H,16,17) YCDOGXXXWOHZDQ-UHFFFAOYSA-N 42587 2-furancarboxylic acid [2-(2-methoxycarbonylanilino)-2-oxoethyl] ester::Furan-2-carboxylic acid (2-methoxycarbonyl-phenylcarbamoyl)-methyl ester::MLS000075132::SMR000014181::[2-(2-methoxycarbonylanilino)-2-oxoethyl] furan-2-carboxylate::[2-[(2-methoxycarbonylphenyl)amino]-2-oxidanylidene-ethyl] furan-2-carboxylate::cid_648810::furan-2-carboxylic acid [2-(2-carbomethoxyanilino)-2-keto-ethyl] ester Mitogen-activated protein kinase 10 Homo sapiens 56710 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42587&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 648810 252623280 ZINC00806226 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79548 Cc1ccc2nc(Cc3ccc(N)cc3)oc2c1 InChI=1S/C15H14N2O/c1-10-2-7-13-14(8-10)18-15(17-13)9-11-3-5-12(16)6-4-11/h2-8H,9,16H2,1H3 ZNLFWZMTRFKKRA-UHFFFAOYSA-N 42588 4-(6-Methyl-benzooxazol-2-ylmethyl)-phenylamine::4-[(6-methyl-1,3-benzoxazol-2-yl)methyl]aniline::MLS000033701::SMR000013747::[4-[(6-methyl-1,3-benzoxazol-2-yl)methyl]phenyl]amine::cid_648914 Mitogen-activated protein kinase 10 Homo sapiens 49850 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42588&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 648914 252623281 ZINC00215288 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79549 CC(=O)c1sc(Nc2ccccn2)nc1C InChI=1S/C11H11N3OS/c1-7-10(8(2)15)16-11(13-7)14-9-5-3-4-6-12-9/h3-6H,1-2H3,(H,12,13,14) HYVIYVTYOOLRJD-UHFFFAOYSA-N 42589 1-[4-Methyl-2-(pyridin-2-ylamino)-thiazol-5-yl]-ethanone::1-[4-methyl-2-(2-pyridinylamino)-5-thiazolyl]ethanone;hydrobromide::1-[4-methyl-2-(2-pyridylamino)thiazol-5-yl]ethanone;hydrobromide::1-[4-methyl-2-(pyridin-2-ylamino)-1,3-thiazol-5-yl]ethanone;hydrobromide::MLS000034319::SMR000009208::cid_6602572 Mitogen-activated protein kinase 10 Homo sapiens 40270 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42589&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 616262 252623282 ZINC06389850 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79550 COc1cc2nc(C3CCC3)n(NC(=O)COc3ccccc3)c(=O)c2cc1OC InChI=1S/C22H23N3O5/c1-28-18-11-16-17(12-19(18)29-2)23-21(14-7-6-8-14)25(22(16)27)24-20(26)13-30-15-9-4-3-5-10-15/h3-5,9-12,14H,6-8,13H2,1-2H3,(H,24,26) DRXGFGKJIBHBHW-UHFFFAOYSA-N 42590 MLS000076496::N-(2-Cyclobutyl-6,7-dimethoxy-4-oxo-4H-quinazolin-3-yl)-2-phenoxy-acetamide::N-(2-cyclobutyl-4-keto-6,7-dimethoxy-quinazolin-3-yl)-2-phenoxy-acetamide::N-(2-cyclobutyl-6,7-dimethoxy-4-oxidanylidene-quinazolin-3-yl)-2-phenoxy-ethanamide::N-(2-cyclobutyl-6,7-dimethoxy-4-oxo-3-quinazolinyl)-2-phenoxyacetamide::N-(2-cyclobutyl-6,7-dimethoxy-4-oxoquinazolin-3-yl)-2-phenoxyacetamide::SMR000007510::cid_649017 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42590&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 649017 252623283 ZINC01365187 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79551 CCOc1cccc(NC(=O)C2CCCN(C2)S(=O)(=O)c2ccc(cc2)-n2cnnn2)c1 InChI=1S/C21H24N6O4S/c1-2-31-19-7-3-6-17(13-19)23-21(28)16-5-4-12-26(14-16)32(29,30)20-10-8-18(9-11-20)27-15-22-24-25-27/h3,6-11,13,15-16H,2,4-5,12,14H2,1H3,(H,23,28) AMLIVHYOJNXUNR-UHFFFAOYSA-N 42591 1-(4-Tetrazol-1-yl-benzenesulfonyl)-piperidine-3-carboxylic acid (3-ethoxy-phenyl)-amide::MLS000031602::N-(3-ethoxyphenyl)-1-[4-(1,2,3,4-tetrazol-1-yl)phenyl]sulfonyl-piperidine-3-carboxamide::N-(3-ethoxyphenyl)-1-[4-(1-tetrazolyl)phenyl]sulfonyl-3-piperidinecarboxamide::N-(3-ethoxyphenyl)-1-[4-(tetrazol-1-yl)phenyl]sulfonylpiperidine-3-carboxamide::N-m-phenetyl-1-[4-(tetrazol-1-yl)phenyl]sulfonyl-nipecotamide::SMR000006052::cid_649200 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42591&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 649200 252623284 ZINC01365452 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79552 COC(=O)c1ccccc1NC(=O)CN1CCC(CC1)C(=O)c1ccc2OCCOc2c1 InChI=1S/C24H26N2O6/c1-30-24(29)18-4-2-3-5-19(18)25-22(27)15-26-10-8-16(9-11-26)23(28)17-6-7-20-21(14-17)32-13-12-31-20/h2-7,14,16H,8-13,15H2,1H3,(H,25,27) BIMSTZCCZSBBOL-UHFFFAOYSA-N 42592 2-[[2-[4-(2,3-dihydro-1,4-benzodioxin-6-carbonyl)piperidino]acetyl]amino]benzoic acid methyl ester::2-[[2-[4-[2,3-dihydro-1,4-benzodioxin-6-yl(oxo)methyl]-1-piperidinyl]-1-oxoethyl]amino]benzoic acid methyl ester::2-{2-[4-(2,3-Dihydro-benzo[1,4]dioxine-6-carbonyl)-piperidin-1-yl]-acetylamino}-benzoic acid methyl ester::MLS000034078::SMR000007078::cid_649294::methyl 2-[2-[4-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)piperidin-1-yl]ethanoylamino]benzoate::methyl 2-[[2-[4-(2,3-dihydro-1,4-benzodioxine-6-carbonyl)piperidin-1-yl]acetyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 23820 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42592&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 649294 252623285 ZINC04400801 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79553 CC(NCc1ccco1)=C1C(=O)c2ccccc2C1=O InChI=1S/C16H13NO3/c1-10(17-9-11-5-4-8-20-11)14-15(18)12-6-2-3-7-13(12)16(14)19/h2-8,17H,9H2,1H3 HFXXPLUGEMBMFQ-UHFFFAOYSA-N 42593 2-[1-(2-furanylmethylamino)ethylidene]indene-1,3-dione::2-[1-(2-furfurylamino)ethylidene]indane-1,3-quinone::2-[1-(furan-2-ylmethylamino)ethylidene]indene-1,3-dione::2-{1-[(Furan-2-ylmethyl)-amino]-ethylidene}-indan-1,3-dione::MLS000029770::SMR000011625::cid_649653 Mitogen-activated protein kinase 10 Homo sapiens 30890 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42593&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 649653 252623286 ZINC13454336 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79554 CC(=O)Nc1cc(OC(C)=O)c2nonc2c1OC(C)=O InChI=1S/C12H11N3O6/c1-5(16)13-8-4-9(19-6(2)17)10-11(15-21-14-10)12(8)20-7(3)18/h4H,1-3H3,(H,13,16) AABQOSHDRSWHSN-UHFFFAOYSA-N 31042 (5-acetamido-4-acetyloxy-2,1,3-benzoxadiazol-7-yl) acetate::(5-acetamido-4-acetyloxy-2,1,3-benzoxadiazol-7-yl) ethanoate::Acetic acid 7-acetoxy-5-acetylamino-benzo[1,2,5]oxadiazol-4-yl ester::MLS000077136::SMR000008576::acetic acid (5-acetamido-4-acetyloxy-2,1,3-benzoxadiazol-7-yl) ester::acetic acid (6-acetamido-7-acetoxy-benzofurazan-4-yl) ester::cid_597363 Mitogen-activated protein kinase 10 Homo sapiens 46600 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31042&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 597363 252615294 ZINC00368832 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79555 CCOC(=O)c1ccccc1NC(=O)CSc1ncc(C(=O)OCC)c(N)n1 InChI=1S/C18H20N4O5S/c1-3-26-16(24)11-7-5-6-8-13(11)21-14(23)10-28-18-20-9-12(15(19)22-18)17(25)27-4-2/h5-9H,3-4,10H2,1-2H3,(H,21,23)(H2,19,20,22) CRPXWMYEKXYXIE-UHFFFAOYSA-N 42594 4-Amino-2-[(2-ethoxycarbonyl-phenylcarbamoyl)-methylsulfanyl]-pyrimidine-5-carboxylic acid ethyl ester::4-amino-2-[[2-(2-carbethoxyanilino)-2-keto-ethyl]thio]pyrimidine-5-carboxylic acid ethyl ester::4-amino-2-[[2-(2-ethoxycarbonylanilino)-2-oxoethyl]thio]-5-pyrimidinecarboxylic acid ethyl ester::MLS000070312::SMR000001887::cid_649913::ethyl 4-amino-2-[2-(2-ethoxycarbonylanilino)-2-oxoethyl]sulfanylpyrimidine-5-carboxylate::ethyl 4-azanyl-2-[2-[(2-ethoxycarbonylphenyl)amino]-2-oxidanylidene-ethyl]sulfanyl-pyrimidine-5-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 6628 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42594&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 649913 252623287 ZINC04093179 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79556 O=C(NC1CCCC1)c1cccnc1N1CCCCCC1 InChI=1S/C17H25N3O/c21-17(19-14-8-3-4-9-14)15-10-7-11-18-16(15)20-12-5-1-2-6-13-20/h7,10-11,14H,1-6,8-9,12-13H2,(H,19,21) XLRBTFVOCRGCSN-UHFFFAOYSA-N 42595 2-(1-azepanyl)-N-cyclopentyl-3-pyridinecarboxamide::2-(azepan-1-yl)-N-cyclopentyl-nicotinamide::2-(azepan-1-yl)-N-cyclopentyl-pyridine-3-carboxamide::2-(azepan-1-yl)-N-cyclopentylpyridine-3-carboxamide::2-Azepan-1-yl-N-cyclopentyl-nicotinamide::MLS000029492::SMR000003787::cid_650023 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42595&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 650023 252623288 ZINC20098053 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79557 CCOC(=O)c1ccc2[nH]c3c(CCCCC3=O)c2c1 InChI=1S/C16H17NO3/c1-2-20-16(19)10-7-8-13-12(9-10)11-5-3-4-6-14(18)15(11)17-13/h7-9,17H,2-6H2,1H3 PZHYUMZMPMKXRM-UHFFFAOYSA-N 42596 6-Oxo-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-2-carboxylic acid ethyl ester::6-keto-7,8,9,10-tetrahydro-5H-cyclohept[b]indole-2-carboxylic acid ethyl ester::6-oxo-7,8,9,10-tetrahydro-5H-cyclohepta[b]indole-2-carboxylic acid ethyl ester::MLS000029731::SMR000011001::cid_650387::ethyl 6-oxidanylidene-7,8,9,10-tetrahydro-5H-cyclohepta[b]indole-2-carboxylate::ethyl 6-oxo-7,8,9,10-tetrahydro-5H-cyclohepta[b]indole-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42596&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 650387 252623289 ZINC00170674 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79558 OC(=O)CSc1ccc2ccccc2n1 InChI=1S/C11H9NO2S/c13-11(14)7-15-10-6-5-8-3-1-2-4-9(8)12-10/h1-6H,7H2,(H,13,14) WOZJGFBFMIWEGN-UHFFFAOYSA-N 42597 (Quinolin-2-ylsulfanyl)-acetic acid::2-(2-quinolinylthio)acetic acid::2-(2-quinolylthio)acetic acid::2-quinolin-2-ylsulfanylacetic acid::2-quinolin-2-ylsulfanylethanoic acid::MLS000029205::SMR000009740::cid_408543 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42597&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 408543 252623290 ZINC00324466 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79559 COC(=O)c1ccccc1NC(=O)CN1CCC(CC1)NC(=O)c1ccccc1C InChI=1S/C23H27N3O4/c1-16-7-3-4-8-18(16)22(28)24-17-11-13-26(14-12-17)15-21(27)25-20-10-6-5-9-19(20)23(29)30-2/h3-10,17H,11-15H2,1-2H3,(H,24,28)(H,25,27) OEANPIFWBBTVJJ-UHFFFAOYSA-N 42598 2-[[2-[4-(o-toluoylamino)piperidino]acetyl]amino]benzoic acid methyl ester::2-[[2-[4-[[(2-methylphenyl)-oxomethyl]amino]-1-piperidinyl]-1-oxoethyl]amino]benzoic acid methyl ester::2-{2-[4-(2-Methyl-benzoylamino)-piperidin-1-yl]-acetylamino}-benzoic acid methyl ester::MLS000035345::SMR000006708::cid_651058::methyl 2-[2-[4-[(2-methylphenyl)carbonylamino]piperidin-1-yl]ethanoylamino]benzoate::methyl 2-[[2-[4-[(2-methylbenzoyl)amino]piperidin-1-yl]acetyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 4217 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42598&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 651058 252623291 ZINC04399652 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79560 COC(=O)c1ccccc1NC(=O)CN1CCC(CC1)NC(=O)c1ccc(C)cc1 InChI=1S/C23H27N3O4/c1-16-7-9-17(10-8-16)22(28)24-18-11-13-26(14-12-18)15-21(27)25-20-6-4-3-5-19(20)23(29)30-2/h3-10,18H,11-15H2,1-2H3,(H,24,28)(H,25,27) CYSCIEFIGJZUKN-UHFFFAOYSA-N 42599 2-[[2-[4-(p-toluoylamino)piperidino]acetyl]amino]benzoic acid methyl ester::2-[[2-[4-[[(4-methylphenyl)-oxomethyl]amino]-1-piperidinyl]-1-oxoethyl]amino]benzoic acid methyl ester::2-{2-[4-(4-Methyl-benzoylamino)-piperidin-1-yl]-acetylamino}-benzoic acid methyl ester::MLS000034129::SMR000006707::cid_651323::methyl 2-[2-[4-[(4-methylphenyl)carbonylamino]piperidin-1-yl]ethanoylamino]benzoate::methyl 2-[[2-[4-[(4-methylbenzoyl)amino]piperidin-1-yl]acetyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 3136 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42599&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 651323 252623292 ZINC04388908 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79561 COC(=O)c1cccc(NC(=O)CN2CCC(CC2)NC(=O)c2cc(OC)c(OC)c(OC)c2)c1 InChI=1S/C25H31N3O7/c1-32-20-13-17(14-21(33-2)23(20)34-3)24(30)27-18-8-10-28(11-9-18)15-22(29)26-19-7-5-6-16(12-19)25(31)35-4/h5-7,12-14,18H,8-11,15H2,1-4H3,(H,26,29)(H,27,30) VMFYOGVBCVFXGH-UHFFFAOYSA-N 42600 3-[[1-oxo-2-[4-[[oxo-(3,4,5-trimethoxyphenyl)methyl]amino]-1-piperidinyl]ethyl]amino]benzoic acid methyl ester::3-[[2-[4-[(3,4,5-trimethoxybenzoyl)amino]piperidino]acetyl]amino]benzoic acid methyl ester::3-{2-[4-(3,4,5-Trimethoxy-benzoylamino)-piperidin-1-yl]-acetylamino}-benzoic acid methyl ester::MLS000075067::SMR000006709::cid_651408::methyl 3-[2-[4-[(3,4,5-trimethoxyphenyl)carbonylamino]piperidin-1-yl]ethanoylamino]benzoate::methyl 3-[[2-[4-[(3,4,5-trimethoxybenzoyl)amino]piperidin-1-yl]acetyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 1701 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42600&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 651408 252623293 ZINC04388873 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79562 CC(NCCCn1ccnc1)=C1C(=O)c2ccccc2C1=O InChI=1S/C17H17N3O2/c1-12(19-7-4-9-20-10-8-18-11-20)15-16(21)13-5-2-3-6-14(13)17(15)22/h2-3,5-6,8,10-11,19H,4,7,9H2,1H3 MSBZXAIKAVZFSZ-UHFFFAOYSA-N 42601 2-[1-(3-Imidazol-1-yl-propylamino)-ethylidene]-indan-1,3-dione::2-[1-(3-imidazol-1-ylpropylamino)ethylidene]indane-1,3-quinone::2-[1-(3-imidazol-1-ylpropylamino)ethylidene]indene-1,3-dione::2-[1-[3-(1-imidazolyl)propylamino]ethylidene]indene-1,3-dione::MLS000077162::SMR000011624::cid_651980 Mitogen-activated protein kinase 10 Homo sapiens 35700 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42601&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 651980 252623294 ZINC13739265 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79563 COc1ccc2c(Cl)c(sc2c1)C(N)=O InChI=1S/C10H8ClNO2S/c1-14-5-2-3-6-7(4-5)15-9(8(6)11)10(12)13/h2-4H,1H3,(H2,12,13) IWPCUYGXTLHCHD-UHFFFAOYSA-N 37876 3-Chloro-6-methoxy-benzo[b]thiophene-2-carboxylic acid amide::3-chloranyl-6-methoxy-1-benzothiophene-2-carboxamide::3-chloro-6-methoxy-1-benzothiophene-2-carboxamide::3-chloro-6-methoxy-benzothiophene-2-carboxamide::MLS000075717::SMR000012987::cid_652152 Mitogen-activated protein kinase 10 Homo sapiens 68290 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37876&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 652152 252618834 ZINC00045997 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79564 COc1ccc2ncn(-c3ccccc3)c2c1 InChI=1S/C14H12N2O/c1-17-12-7-8-13-14(9-12)16(10-15-13)11-5-3-2-4-6-11/h2-10H,1H3 DBDPQMUWFPDEFP-UHFFFAOYSA-N 3859 1-Phenylbenzimidazole deriv. 76::6-methoxy-1-phenyl-1H-1,3-benzodiazole::cid_652633 Mitogen-activated protein kinase 10 Homo sapiens 34880 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=3859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=3859&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 652633 8033565 ZINC00361259 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79565 COc1ccccc1NC(=O)CN1CCC(CC1)n1nnc2cc(F)ccc12 InChI=1S/C20H22FN5O2/c1-28-19-5-3-2-4-16(19)22-20(27)13-25-10-8-15(9-11-25)26-18-7-6-14(21)12-17(18)23-24-26/h2-7,12,15H,8-11,13H2,1H3,(H,22,27) ZSDGAINOGMRYMO-UHFFFAOYSA-N 42602 2-[4-(5-Fluoro-benzotriazol-1-yl)-piperidin-1-yl]-N-(2-methoxy-phenyl)-acetamide::2-[4-(5-fluoranylbenzotriazol-1-yl)piperidin-1-yl]-N-(2-methoxyphenyl)ethanamide::2-[4-(5-fluoro-1-benzotriazolyl)-1-piperidinyl]-N-(2-methoxyphenyl)acetamide::2-[4-(5-fluorobenzotriazol-1-yl)piperidin-1-yl]-N-(2-methoxyphenyl)acetamide::2-[4-(5-fluorobenzotriazol-1-yl)piperidino]-N-(2-methoxyphenyl)acetamide::MLS000030175::SMR000006524::cid_652680 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42602&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 652680 252623295 ZINC04388390 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79566 Cn1ncc2c(NCc3ccccc3)ncnc12 InChI=1S/C13H13N5/c1-18-13-11(8-17-18)12(15-9-16-13)14-7-10-5-3-2-4-6-10/h2-6,8-9H,7H2,1H3,(H,14,15,16) IGHOYJOUGQNIAB-UHFFFAOYSA-N 42603 1-methyl-N-(phenylmethyl)-4-pyrazolo[3,4-d]pyrimidinamine::1-methyl-N-(phenylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine::Benzyl-(1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-amine::MLS000068333::N-benzyl-1-methylpyrazolo[3,4-d]pyrimidin-4-amine::SMR000011162::benzyl-(1-methylpyrazolo[3,4-d]pyrimidin-4-yl)amine::cid_219778 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42603&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 219778 252623296 ZINC00838233 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79567 CC(=O)Nc1nc(C)c(s1)-c1csc(Nc2ccc(O)cc2)n1 InChI=1S/C15H14N4O2S2/c1-8-13(23-15(16-8)17-9(2)20)12-7-22-14(19-12)18-10-3-5-11(21)6-4-10/h3-7,21H,1-2H3,(H,18,19)(H,16,17,20) LVRAAIKDYFGGMD-UHFFFAOYSA-N 42604 MLS000031874::N-[2-(4-Hydroxy-phenylamino)-4'-methyl-[4,5']bithiazolyl-2'-yl]-acetamide::N-[5-[2-(4-hydroxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide;hydrobromide::N-[5-[2-(4-hydroxyanilino)-4-thiazolyl]-4-methyl-2-thiazolyl]acetamide;hydrobromide::N-[5-[2-(4-hydroxyanilino)thiazol-4-yl]-4-methyl-thiazol-2-yl]acetamide;hydrobromide::N-[5-[2-[(4-hydroxyphenyl)amino]-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide;hydrobromide::SMR000010230::cid_2877277 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42604&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 653511 252623297 ZINC04092534 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79568 CCCc1nc(SCC(=O)Nc2cc(C)on2)c2ccccc2n1 InChI=1S/C17H18N4O2S/c1-3-6-14-18-13-8-5-4-7-12(13)17(20-14)24-10-16(22)19-15-9-11(2)23-21-15/h4-5,7-9H,3,6,10H2,1-2H3,(H,19,21,22) MQSYQADINVVTLN-UHFFFAOYSA-N 42605 MLS000073796::N-(5-Methyl-isoxazol-3-yl)-2-(2-propyl-quinazolin-4-ylsulfanyl)-acetamide::N-(5-methyl-1,2-oxazol-3-yl)-2-(2-propylquinazolin-4-yl)sulfanyl-ethanamide::N-(5-methyl-1,2-oxazol-3-yl)-2-(2-propylquinazolin-4-yl)sulfanylacetamide::N-(5-methyl-3-isoxazolyl)-2-[(2-propyl-4-quinazolinyl)thio]acetamide::N-(5-methylisoxazol-3-yl)-2-[(2-propylquinazolin-4-yl)thio]acetamide::SMR000006835::cid_653552 Mitogen-activated protein kinase 10 Homo sapiens 83490 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42605&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 653552 252623298 ZINC01342760 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79569 CCOc1ccccc1NC(=O)COc1cccc(c1)-n1cnnn1 InChI=1S/C17H17N5O3/c1-2-24-16-9-4-3-8-15(16)19-17(23)11-25-14-7-5-6-13(10-14)22-12-18-20-21-22/h3-10,12H,2,11H2,1H3,(H,19,23) JXLVHCHNPQWTAY-UHFFFAOYSA-N 42606 MLS000032451::N-(2-Ethoxy-phenyl)-2-(3-tetrazol-1-yl-phenoxy)-acetamide::N-(2-ethoxyphenyl)-2-[3-(1,2,3,4-tetrazol-1-yl)phenoxy]ethanamide::N-(2-ethoxyphenyl)-2-[3-(1-tetrazolyl)phenoxy]acetamide::N-(2-ethoxyphenyl)-2-[3-(tetrazol-1-yl)phenoxy]acetamide::N-o-phenetyl-2-[3-(tetrazol-1-yl)phenoxy]acetamide::SMR000002019::cid_654404 Mitogen-activated protein kinase 10 Homo sapiens 69200 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42606&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 654404 252623299 ZINC00420457 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79570 CSCCC(Nc1ncnc2ccc(Br)cc12)C(O)=O InChI=1S/C13H14BrN3O2S/c1-20-5-4-11(13(18)19)17-12-9-6-8(14)2-3-10(9)15-7-16-12/h2-3,6-7,11H,4-5H2,1H3,(H,18,19)(H,15,16,17) IUHZVPMVQBUAIR-UHFFFAOYSA-N 42607 2-(6-Bromo-quinazolin-4-ylamino)-4-methylsulfanyl-butyric acid::2-[(6-bromanylquinazolin-4-yl)amino]-4-methylsulfanyl-butanoic acid;hydrochloride::2-[(6-bromo-4-quinazolinyl)amino]-4-(methylthio)butanoic acid;hydrochloride::2-[(6-bromoquinazolin-4-yl)amino]-4-(methylthio)butyric acid;hydrochloride::2-[(6-bromoquinazolin-4-yl)amino]-4-methylsulfanylbutanoic acid;hydrochloride::MLS000032173::SMR000011110::cid_2787398 Mitogen-activated protein kinase 10 Homo sapiens 45020 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42607&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 655842 252623300 ZINC01766184 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79571 CC(=O)Nc1ccc(cc1)S(=O)(=O)N1CCC(CC1)n1cnc2cc(F)ccc12 InChI=1S/C20H21FN4O3S/c1-14(26)23-16-3-5-18(6-4-16)29(27,28)24-10-8-17(9-11-24)25-13-22-19-12-15(21)2-7-20(19)25/h2-7,12-13,17H,8-11H2,1H3,(H,23,26) LUQOFXNIKAEUIY-UHFFFAOYSA-N 42608 MLS000074561::N-[4-[4-(5-fluoranylbenzimidazol-1-yl)piperidin-1-yl]sulfonylphenyl]ethanamide::N-[4-[4-(5-fluorobenzimidazol-1-yl)piperidin-1-yl]sulfonylphenyl]acetamide::N-[4-[4-(5-fluorobenzimidazol-1-yl)piperidino]sulfonylphenyl]acetamide::N-[4-[[4-(5-fluoro-1-benzimidazolyl)-1-piperidinyl]sulfonyl]phenyl]acetamide::N-{4-[4-(5-Fluoro-benzoimidazol-1-yl)-piperidine-1-sulfonyl]-phenyl}-acetamide::SMR000006448::cid_656283 Mitogen-activated protein kinase 10 Homo sapiens 32230 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42608&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 656283 252623301 ZINC01371030 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79572 C1CN(CCO1)c1nc2ccccc2c2[nH]c3ccccc3c12 InChI=1S/C19H17N3O/c1-3-7-15-13(5-1)17-18(20-15)14-6-2-4-8-16(14)21-19(17)22-9-11-23-12-10-22/h1-8,20H,9-12H2 DGTKIMFDUXFOIV-UHFFFAOYSA-N 42609 4-(11H-indolo[3,2-c]quinolin-6-yl)morpholine::MLS000037878::SMR000036075::cid_657435 Mitogen-activated protein kinase 10 Homo sapiens 30370 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42609&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 657435 252623302 ZINC13116351 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79573 CCOC(=O)c1n[nH]c2ccccc12 InChI=1S/C10H10N2O2/c1-2-14-10(13)9-7-5-3-4-6-8(7)11-12-9/h3-6H,2H2,1H3,(H,11,12) YLKPTYMNELPKOL-UHFFFAOYSA-N 42610 1H-indazole-3-carboxylic acid ethyl ester::MLS000037997::SMR000038481::cid_78251::ethyl 1H-indazole-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42610&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 78251 252623303 ZINC06507027 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79574 c1nnc2c1ccc1[nH]n(nc21)-c1ccccc1 InChI=1S/C13H9N5/c1-2-4-10(5-3-1)18-16-11-7-6-9-8-14-15-12(9)13(11)17-18/h1-8,16H FERMOUYBKYAVSE-UHFFFAOYSA-N 42611 2-phenyl-3H-pyrazolo[3,4-e]benzotriazole::MLS000037898::SMR000038522::cid_657649 Mitogen-activated protein kinase 10 Homo sapiens 42980 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42611&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 657649 252623304 ZINC37867775 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79575 CCOC(=O)c1c(C)[nH]sc1=S InChI=1S/C7H9NO2S2/c1-3-10-6(9)5-4(2)8-12-7(5)11/h8H,3H2,1-2H3 MVTVNNIFOTYHJA-UHFFFAOYSA-N 42612 3-methyl-5-sulfanylidene-2H-isothiazole-4-carboxylic acid ethyl ester::3-methyl-5-thioxo-3-isothiazoline-4-carboxylic acid ethyl ester::MLS000071155::SMR000034068::cid_657881::ethyl 3-methyl-5-sulfanylidene-2H-1,2-thiazole-4-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 30530 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42612&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 657881 252623305 ZINC06507017 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79576 C=CCn1c(=S)[nH]c2ccccc2c1=O InChI=1S/C11H10N2OS/c1-2-7-13-10(14)8-5-3-4-6-9(8)12-11(13)15/h2-6H,1,7H2,(H,12,15) SJUBWTIKDYWHEB-UHFFFAOYSA-N 42613 3-allyl-2-thioxo-1H-quinazolin-4-one::3-prop-2-enyl-2-sulfanylidene-1H-quinazolin-4-one::MLS000071463::SMR000059240::cid_657947 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42613&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 657947 252623306 ZINC00347329 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79577 COc1ccc(cc1)-c1c2CCCc2[nH]c(=S)c1C#N InChI=1S/C16H14N2OS/c1-19-11-7-5-10(6-8-11)15-12-3-2-4-14(12)18-16(20)13(15)9-17/h5-8H,2-4H2,1H3,(H,18,20) IVCIQZKVLKGZAG-UHFFFAOYSA-N 42614 4-(4-methoxyphenyl)-2-sulfanylidene-1,5,6,7-tetrahydrocyclopenta[b]pyridine-3-carbonitrile::4-(4-methoxyphenyl)-2-thioxo-1,5,6,7-tetrahydro-1-pyrindine-3-carbonitrile::MLS000028095::SMR000034696::cid_657993 Mitogen-activated protein kinase 10 Homo sapiens 17640 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42614&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 657993 252623307 ZINC05550212 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79578 Nc1c(sc2nc3CCCCc3c(-c3ccco3)c12)C#N InChI=1S/C16H13N3OS/c17-8-12-15(18)14-13(11-6-3-7-20-11)9-4-1-2-5-10(9)19-16(14)21-12/h3,6-7H,1-2,4-5,18H2 MHQFILXFNJKKCL-UHFFFAOYSA-N 42615 3-amino-4-(2-furanyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonitrile::3-amino-4-(2-furyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonitrile::3-amino-4-(furan-2-yl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonitrile::3-azanyl-4-(furan-2-yl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carbonitrile::MLS000037767::SMR000039074::cid_658080 Mitogen-activated protein kinase 10 Homo sapiens 68550 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42615&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 658080 252623308 ZINC00497265 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79579 NC(=O)c1cc(Br)cc2c3CCCCc3[nH]c12 InChI=1S/C13H13BrN2O/c14-7-5-9-8-3-1-2-4-11(8)16-12(9)10(6-7)13(15)17/h5-6,16H,1-4H2,(H2,15,17) LXGDQFHGGMIMND-UHFFFAOYSA-N 42616 3-bromanyl-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide::3-bromo-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide::MLS000039236::SMR000039264::cid_658319 Mitogen-activated protein kinase 10 Homo sapiens 12470 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42616&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 658319 252623309 ZINC00499588 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79580 N#Cc1c(NCc2ccccc2)ccnc1NCc1cccnc1 InChI=1S/C19H17N5/c20-11-17-18(23-13-15-5-2-1-3-6-15)8-10-22-19(17)24-14-16-7-4-9-21-12-16/h1-10,12H,13-14H2,(H2,22,23,24) ZDVBOUMTYMSOFM-UHFFFAOYSA-N 42617 4-(benzylamino)-2-(3-pyridylmethylamino)nicotinonitrile::4-(benzylamino)-2-(pyridin-3-ylmethylamino)pyridine-3-carbonitrile::4-[(phenylmethyl)amino]-2-(3-pyridinylmethylamino)-3-pyridinecarbonitrile::4-[(phenylmethyl)amino]-2-(pyridin-3-ylmethylamino)pyridine-3-carbonitrile::MLS000039253::SMR000039742::cid_658703 Mitogen-activated protein kinase 10 Homo sapiens 3962 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42617&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 658703 252623310 ZINC35938072 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79581 COc1ccc(CN=C(C)C(C#N)C(N)=O)cc1OC InChI=1S/C14H17N3O3/c1-9(11(7-15)14(16)18)17-8-10-4-5-12(19-2)13(6-10)20-3/h4-6,11H,8H2,1-3H3,(H2,16,18) ISZWXSZJTOVKOK-UHFFFAOYSA-N 42618 (Z)-2-cyano-3-(veratrylamino)but-2-enamide::(Z)-2-cyano-3-[(3,4-dimethoxyphenyl)methylamino]-2-butenamide::(Z)-2-cyano-3-[(3,4-dimethoxyphenyl)methylamino]but-2-enamide::MLS000039238::SMR000039871::cid_658795 Mitogen-activated protein kinase 10 Homo sapiens 8417 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42618&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 7099299 252623311 51689 ZINC04102544 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79582 Cc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1 InChI=1S/C14H13N3/c1-8-2-5-12-11(6-8)10-4-3-9-7-15-17-13(9)14(10)16-12/h2,5-7,16H,3-4H2,1H3,(H,15,17) BEDRASDCVGOBRO-UHFFFAOYSA-N 34578 7-methyl-1,2,4,5-tetrahydropyrazolo[3,4-a]carbazole::MLS000038265::SMR000040027::cid_5389109 Mitogen-activated protein kinase 10 Homo sapiens 16450 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34578&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5389109 252617231 ZINC13129922 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79583 CC(=Nc1cccc(F)c1)C(C#N)C(N)=O InChI=1S/C11H10FN3O/c1-7(10(6-13)11(14)16)15-9-4-2-3-8(12)5-9/h2-5,10H,1H3,(H2,14,16) CDNBHUKBYZQGTC-UHFFFAOYSA-N 42619 (E)-2-cyano-3-(3-fluoroanilino)-2-butenamide::(E)-2-cyano-3-(3-fluoroanilino)but-2-enamide::(E)-2-cyano-3-[(3-fluorophenyl)amino]but-2-enamide::MLS000038560::SMR000040095::cid_659137 Mitogen-activated protein kinase 10 Homo sapiens 10540 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42619&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896538 252623312 51689 ZINC00506129 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79584 COC(=O)c1cc(Br)c(=O)n(Cc2cccnc2)c1 InChI=1S/C13H11BrN2O3/c1-19-13(18)10-5-11(14)12(17)16(8-10)7-9-3-2-4-15-6-9/h2-6,8H,7H2,1H3 MXHGRGVULPJGRE-UHFFFAOYSA-N 42620 5-bromo-6-keto-1-(3-pyridylmethyl)nicotinic acid methyl ester::5-bromo-6-oxo-1-(3-pyridinylmethyl)-3-pyridinecarboxylic acid methyl ester::MLS000078372::SMR000040392::cid_659277::methyl 5-bromanyl-6-oxidanylidene-1-(pyridin-3-ylmethyl)pyridine-3-carboxylate::methyl 5-bromo-6-oxo-1-(pyridin-3-ylmethyl)pyridine-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42620&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 659277 252623313 ZINC00507601 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79585 O=c1[nH]c2ccccc2c2nc3ccccn3c12 InChI=1S/C14H9N3O/c18-14-13-12(9-5-1-2-6-10(9)15-14)16-11-7-3-4-8-17(11)13/h1-8H,(H,15,18) HTLQIPSFRWPCRL-UHFFFAOYSA-N 42621 MLS000078956::SMR000035661::cid_616556 Mitogen-activated protein kinase 10 Homo sapiens 13820 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42621&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 616556 242053028 ZINC08578866 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79586 O=C1c2ccccc2-c2onc3ccc(NCc4ccco4)c1c23 InChI=1S/C19H12N2O3/c22-18-12-5-1-2-6-13(12)19-17-15(21-24-19)8-7-14(16(17)18)20-10-11-4-3-9-23-11/h1-9,20H,10H2 FIXGNCWNTHTYMQ-UHFFFAOYSA-N 32035 MLS000080234::SMR000040438::cid_659413 Mitogen-activated protein kinase 10 Homo sapiens 23960 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32035&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 659413 242052848 ZINC00507877 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79587 C1Cc2[nH]nc(c2C1)-c1ccccc1 InChI=1S/C12H12N2/c1-2-5-9(6-3-1)12-10-7-4-8-11(10)13-14-12/h1-3,5-6H,4,7-8H2,(H,13,14) VHFKRPJDQQZAOP-UHFFFAOYSA-N 42622 3-phenyl-1,4,5,6-tetrahydrocyclopenta[c]pyrazole::MLS000038915::SMR000040573::cid_120035 Mitogen-activated protein kinase 10 Homo sapiens 50880 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42622&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 120035 252623314 ZINC87711561 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79588 Cc1cc(O)ccc1-c1cnc2ccccc2n1 InChI=1S/C15H12N2O/c1-10-8-11(18)6-7-12(10)15-9-16-13-4-2-3-5-14(13)17-15/h2-9,18H,1H3 ZJZZYSKZHPOANN-UHFFFAOYSA-N 42623 (4Z)-3-methyl-4-(1H-quinoxalin-2-ylidene)-1-cyclohexa-2,5-dienone::(4Z)-3-methyl-4-(1H-quinoxalin-2-ylidene)cyclohexa-2,5-dien-1-one::MLS000027691::SMR000036679::cid_5389156 Mitogen-activated protein kinase 10 Homo sapiens 28060 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42623&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5389156 252623315 ZINC61872428 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79589 COc1cccc(OCC(=O)Nc2ccccc2C(N)=O)c1 InChI=1S/C16H16N2O4/c1-21-11-5-4-6-12(9-11)22-10-15(19)18-14-8-3-2-7-13(14)16(17)20/h2-9H,10H2,1H3,(H2,17,20)(H,18,19) AGCXEVKTJDFEIW-UHFFFAOYSA-N 42624 2-[2-(3-methoxyphenoxy)ethanoylamino]benzamide::2-[[2-(3-methoxyphenoxy)-1-oxoethyl]amino]benzamide::2-[[2-(3-methoxyphenoxy)acetyl]amino]benzamide::MLS000039052::SMR000034535::cid_659792 Mitogen-activated protein kinase 10 Homo sapiens 55240 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42624&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 659792 252623316 ZINC04192030 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79590 O=C(Nc1ccccn1)c1nc[nH]c1C(=O)c1ccccc1 InChI=1S/C16H12N4O2/c21-15(11-6-2-1-3-7-11)13-14(19-10-18-13)16(22)20-12-8-4-5-9-17-12/h1-10H,(H,18,19)(H,17,20,22) XWEAHMYQJKXLML-UHFFFAOYSA-N 42625 4-(phenylcarbonyl)-N-pyridin-2-yl-1H-imidazole-5-carboxamide::4-benzoyl-N-(2-pyridinyl)-1H-imidazole-5-carboxamide::4-benzoyl-N-(2-pyridyl)-1H-imidazole-5-carboxamide::4-benzoyl-N-pyridin-2-yl-1H-imidazole-5-carboxamide::MLS000079316::SMR000040890::cid_604408 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42625&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 604408 252623317 ZINC06499384 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79591 COC(=O)c1c2CCCCc2nc(N)c1C#N InChI=1S/C12H13N3O2/c1-17-12(16)10-7-4-2-3-5-9(7)15-11(14)8(10)6-13/h2-5H2,1H3,(H2,14,15) KTHIJTUJUXPDDZ-UHFFFAOYSA-N 42626 2-amino-3-cyano-5,6,7,8-tetrahydroquinoline-4-carboxylic acid methyl ester::MLS000079607::SMR000037010::cid_612226::methyl 2-amino-3-cyano-5,6,7,8-tetrahydroquinoline-4-carboxylate::methyl 2-azanyl-3-cyano-5,6,7,8-tetrahydroquinoline-4-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 60150 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 612226 252623318 ZINC20024914 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79592 OCCCN1c2ccccc2Nc2nnc(cc12)-c1ccccc1 InChI=1S/C19H18N4O/c24-12-6-11-23-17-10-5-4-9-15(17)20-19-18(23)13-16(21-22-19)14-7-2-1-3-8-14/h1-5,7-10,13,24H,6,11-12H2,(H,20,22) ZNQPBWPWNXLKKI-UHFFFAOYSA-N 39590 3-(3-phenyl-10H-pyridazino[4,3-b]quinoxalin-5-yl)-1-propanol::3-(3-phenyl-10H-pyridazino[4,3-b]quinoxalin-5-yl)propan-1-ol::MLS000079256::SMR000037636::cid_6400926 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39590&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 6400926 252620480 ZINC01792988 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79593 C(Nc1ncnc2n(ncc12)-c1ccccc1)c1ccccc1 InChI=1S/C18H15N5/c1-3-7-14(8-4-1)11-19-17-16-12-22-23(18(16)21-13-20-17)15-9-5-2-6-10-15/h1-10,12-13H,11H2,(H,19,20,21) XAODGRCKBVFBPM-UHFFFAOYSA-N 42627 1-phenyl-N-(phenylmethyl)-4-pyrazolo[3,4-d]pyrimidinamine::1-phenyl-N-(phenylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine::MLS000080013::N-benzyl-1-phenylpyrazolo[3,4-d]pyrimidin-4-amine::SMR000035744::benzyl-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)amine::cid_660012 Mitogen-activated protein kinase 10 Homo sapiens 75810 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 660012 252623319 ZINC00346619 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79594 COC(=O)c1cc(Br)c(=O)n(Cc2ccc3OCOc3c2)c1 InChI=1S/C15H12BrNO5/c1-20-15(19)10-5-11(16)14(18)17(7-10)6-9-2-3-12-13(4-9)22-8-21-12/h2-5,7H,6,8H2,1H3 JPCKTZROQCNHJX-UHFFFAOYSA-N 42628 1-(1,3-benzodioxol-5-ylmethyl)-5-bromo-6-oxo-3-pyridinecarboxylic acid methyl ester::5-bromo-6-keto-1-piperonyl-nicotinic acid methyl ester::MLS000078368::SMR000037645::cid_660128::methyl 1-(1,3-benzodioxol-5-ylmethyl)-5-bromanyl-6-oxidanylidene-pyridine-3-carboxylate::methyl 1-(1,3-benzodioxol-5-ylmethyl)-5-bromo-6-oxopyridine-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 6827 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42628&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 660128 252623320 ZINC04311529 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79595 COc1ccc(cc1OC)C1C(C#N)C(=N)SC(=N)C1C#N InChI=1S/C15H14N4O2S/c1-20-11-4-3-8(5-12(11)21-2)13-9(6-16)14(18)22-15(19)10(13)7-17/h3-5,9-10,13,18-19H,1-2H3 GZLJBHISCACBER-UHFFFAOYSA-N 42629 2,6-bis(azanyl)-4-(3,4-dimethoxyphenyl)-4H-thiopyran-3,5-dicarbonitrile::2,6-diamino-4-(3,4-dimethoxyphenyl)-4H-thiopyran-3,5-dicarbonitrile::MLS000078143::SMR000035127::cid_660180 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42629&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896539 252623321 ZINC00051741 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79596 Nc1nc(SCc2ccncc2)c(C#N)c(-c2cccs2)c1C#N InChI=1S/C17H11N5S2/c18-8-12-15(14-2-1-7-23-14)13(9-19)17(22-16(12)20)24-10-11-3-5-21-6-4-11/h1-7H,10H2,(H2,20,22) GZVBMZVUQHYVFH-UHFFFAOYSA-N 42630 2-amino-6-(4-pyridylmethylthio)-4-(2-thienyl)dinicotinonitrile::2-amino-6-(pyridin-4-ylmethylsulfanyl)-4-thiophen-2-ylpyridine-3,5-dicarbonitrile::2-amino-6-(pyridin-4-ylmethylthio)-4-thiophen-2-ylpyridine-3,5-dicarbonitrile::2-azanyl-6-(pyridin-4-ylmethylsulfanyl)-4-thiophen-2-yl-pyridine-3,5-dicarbonitrile::MLS000036923::SMR000036534::cid_660289 Mitogen-activated protein kinase 10 Homo sapiens 54760 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42630&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 660289 252623322 ZINC17359843 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79597 COc1cccc(c1)C(=O)c1sc(NC(C)C)nc1N InChI=1S/C14H17N3O2S/c1-8(2)16-14-17-13(15)12(20-14)11(18)9-5-4-6-10(7-9)19-3/h4-8H,15H2,1-3H3,(H,16,17) UMWFADAYTHDOHK-UHFFFAOYSA-N 39091 MLS000036929::SMR000041329::[4-amino-2-(isopropylamino)thiazol-5-yl]-(3-methoxyphenyl)methanone::[4-amino-2-(propan-2-ylamino)-1,3-thiazol-5-yl]-(3-methoxyphenyl)methanone::[4-amino-2-(propan-2-ylamino)-5-thiazolyl]-(3-methoxyphenyl)methanone::[4-azanyl-2-(propan-2-ylamino)-1,3-thiazol-5-yl]-(3-methoxyphenyl)methanone::cid_660516 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39091&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 660516 252619990 ZINC04327622 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79598 COC(=O)c1ccc(CN2C(=O)C(N=O)c3ccccc23)o1 InChI=1S/C15H12N2O5/c1-21-15(19)12-7-6-9(22-12)8-17-11-5-3-2-4-10(11)13(16-20)14(17)18/h2-7,13H,8H2,1H3 NHSLINFDDMEWSI-UHFFFAOYSA-N 42631 5-[[(3Z)-3-hydroximino-2-keto-indolin-1-yl]methyl]furan-2-carboxylic acid methyl ester::5-[[(3Z)-3-hydroxyimino-2-oxo-1-indolyl]methyl]-2-furancarboxylic acid methyl ester::MLS000078058::SMR000034644::cid_6886787::methyl 5-[[(3Z)-3-hydroxyimino-2-oxidanylidene-indol-1-yl]methyl]furan-2-carboxylate::methyl 5-[[(3Z)-3-hydroxyimino-2-oxoindol-1-yl]methyl]furan-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42631&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896540 252623323 ZINC13718514 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79599 COC(=O)c1cc(Br)c(=O)n(Cc2ccncc2)c1 InChI=1S/C13H11BrN2O3/c1-19-13(18)10-6-11(14)12(17)16(8-10)7-9-2-4-15-5-3-9/h2-6,8H,7H2,1H3 KDGHQGPBZNKUHV-UHFFFAOYSA-N 42632 5-bromo-6-keto-1-(4-pyridylmethyl)nicotinic acid methyl ester::5-bromo-6-oxo-1-(pyridin-4-ylmethyl)-3-pyridinecarboxylic acid methyl ester::MLS000078279::SMR000037825::cid_661001::methyl 5-bromanyl-6-oxidanylidene-1-(pyridin-4-ylmethyl)pyridine-3-carboxylate::methyl 5-bromo-6-oxo-1-(pyridin-4-ylmethyl)pyridine-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 66110 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 661001 252623324 ZINC00529141 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79600 COC(=O)c1cc(Br)c(=O)n(Cc2ccc(OC)c(OC)c2)c1 InChI=1S/C16H16BrNO5/c1-21-13-5-4-10(6-14(13)22-2)8-18-9-11(16(20)23-3)7-12(17)15(18)19/h4-7,9H,8H2,1-3H3 KYPSKTLCRCBHDD-UHFFFAOYSA-N 42633 5-bromo-1-[(3,4-dimethoxyphenyl)methyl]-6-oxo-3-pyridinecarboxylic acid methyl ester::5-bromo-6-keto-1-veratryl-nicotinic acid methyl ester::MLS000078283::SMR000037861::cid_661045::methyl 5-bromanyl-1-[(3,4-dimethoxyphenyl)methyl]-6-oxidanylidene-pyridine-3-carboxylate::methyl 5-bromo-1-[(3,4-dimethoxyphenyl)methyl]-6-oxopyridine-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 6677 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 661045 252623325 ZINC01308620 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79601 COC(=O)c1cc(Br)c(=O)n(Cc2ccc(cc2)C(O)=O)c1 InChI=1S/C15H12BrNO5/c1-22-15(21)11-6-12(16)13(18)17(8-11)7-9-2-4-10(5-3-9)14(19)20/h2-6,8H,7H2,1H3,(H,19,20) DWLRRWJAGWDNHZ-UHFFFAOYSA-N 42634 4-[(3-bromanyl-5-methoxycarbonyl-2-oxidanylidene-pyridin-1-yl)methyl]benzoic acid::4-[(3-bromo-5-carbomethoxy-2-keto-1-pyridyl)methyl]benzoic acid::4-[(3-bromo-5-methoxycarbonyl-2-oxo-1-pyridinyl)methyl]benzoic acid::4-[(3-bromo-5-methoxycarbonyl-2-oxopyridin-1-yl)methyl]benzoic acid::MLS000078287::SMR000037878::cid_661157 Mitogen-activated protein kinase 10 Homo sapiens 28000 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42634&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 661157 252623326 ZINC01247497 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79602 Cn1c(NC(=O)c2ccccc2NC(=O)c2ccco2)nc2ccccc12 InChI=1S/C20H16N4O3/c1-24-16-10-5-4-9-15(16)22-20(24)23-18(25)13-7-2-3-8-14(13)21-19(26)17-11-6-12-27-17/h2-12H,1H3,(H,21,26)(H,22,23,25) BTSJVKAVKWMIAP-UHFFFAOYSA-N 38320 MLS000078702::N-[2-[(1-methylbenzimidazol-2-yl)carbamoyl]phenyl]-2-furamide::N-[2-[(1-methylbenzimidazol-2-yl)carbamoyl]phenyl]furan-2-carboxamide::N-[2-[[(1-methyl-2-benzimidazolyl)amino]-oxomethyl]phenyl]-2-furancarboxamide::SMR000037343::cid_661261 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38320&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 661261 252619237 ZINC17159612 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79603 CC(Sc1ccc2ccccc2n1)C(O)=O InChI=1S/C12H11NO2S/c1-8(12(14)15)16-11-7-6-9-4-2-3-5-10(9)13-11/h2-8H,1H3,(H,14,15) JLYPYACZXPBHLU-UHFFFAOYSA-N 42635 2-(2-quinolinylthio)propanoic acid::2-(2-quinolylthio)propionic acid::2-quinolin-2-ylsulfanylpropanoic acid::MLS000036607::SMR000042099::cid_661441 Mitogen-activated protein kinase 10 Homo sapiens 4873 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42635&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 661441 252623327 ZINC00553696 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79604 OC(=O)CCSc1ccc2ccccc2n1 InChI=1S/C12H11NO2S/c14-12(15)7-8-16-11-6-5-9-3-1-2-4-10(9)13-11/h1-6H,7-8H2,(H,14,15) QKYKAHGSVSTGFP-UHFFFAOYSA-N 42636 3-(2-quinolinylthio)propanoic acid::3-(2-quinolylthio)propionic acid::3-quinolin-2-ylsulfanylpropanoic acid::MLS000077859::SMR000042255::cid_661670 Mitogen-activated protein kinase 10 Homo sapiens 34840 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 661670 252623328 ZINC06146180 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79605 CCOC(=O)C1=C(C)OC(=N)C(C#N)C1c1cc2ccccc2nc1N1CCCCC1 InChI=1S/C24H26N4O3/c1-3-30-24(29)20-15(2)31-22(26)18(14-25)21(20)17-13-16-9-5-6-10-19(16)27-23(17)28-11-7-4-8-12-28/h5-6,9-10,13,18,21,26H,3-4,7-8,11-12H2,1-2H3 FYLDDOQTNIFHKX-UHFFFAOYSA-N 42637 6-amino-5-cyano-2-methyl-4-(2-piperidino-3-quinolyl)-4H-pyran-3-carboxylic acid ethyl ester::6-amino-5-cyano-2-methyl-4-[2-(1-piperidinyl)-3-quinolinyl]-4H-pyran-3-carboxylic acid ethyl ester::MLS000077501::SMR000042367::cid_661760::ethyl 6-amino-5-cyano-2-methyl-4-(2-piperidin-1-ylquinolin-3-yl)-4H-pyran-3-carboxylate::ethyl 6-azanyl-5-cyano-2-methyl-4-(2-piperidin-1-ylquinolin-3-yl)-4H-pyran-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42637&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896541 252623329 ZINC13115796 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79606 CCOc1ccc(cc1)C(=O)C1C(N(C(=O)C1=O)c1cc(C)on1)c1ccccc1OC InChI=1S/C24H22N2O6/c1-4-31-16-11-9-15(10-12-16)22(27)20-21(17-7-5-6-8-18(17)30-3)26(24(29)23(20)28)19-13-14(2)32-25-19/h5-13,20-21H,4H2,1-3H3 SUOSUPJZEMHPGR-UHFFFAOYSA-N 42638 (4E)-4-[(4-ethoxyphenyl)-hydroxymethylidene]-5-(2-methoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione::(4E)-4-[(4-ethoxyphenyl)-hydroxymethylidene]-5-(2-methoxyphenyl)-1-(5-methyl-3-isoxazolyl)pyrrolidine-2,3-dione::(4E)-4-[(4-ethoxyphenyl)-oxidanyl-methylidene]-5-(2-methoxyphenyl)-1-(5-methyl-1,2-oxazol-3-yl)pyrrolidine-2,3-dione::(4E)-4-[hydroxy(p-phenetyl)methylene]-5-(2-methoxyphenyl)-1-(5-methylisoxazol-3-yl)pyrrolidine-2,3-quinone::MLS000081629::SMR000042658::cid_5389427 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42638&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896542 252623330 ZINC06499098 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79607 COC(=O)c1cc(Br)c(=O)n(c1)-c1nccs1 InChI=1S/C10H7BrN2O3S/c1-16-9(15)6-4-7(11)8(14)13(5-6)10-12-2-3-17-10/h2-5H,1H3 UFCDIXRCVJLNQM-UHFFFAOYSA-N 42639 5-bromo-6-keto-1-thiazol-2-yl-nicotinic acid methyl ester::5-bromo-6-oxo-1-(2-thiazolyl)-3-pyridinecarboxylic acid methyl ester::MLS000036872::SMR000037782::cid_662069::methyl 5-bromanyl-6-oxidanylidene-1-(1,3-thiazol-2-yl)pyridine-3-carboxylate::methyl 5-bromo-6-oxo-1-(1,3-thiazol-2-yl)pyridine-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 76830 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42639&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 662069 252623331 ZINC00521808 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79608 CC(=Nc1ccc(F)cc1)C(C#N)C(N)=O InChI=1S/C11H10FN3O/c1-7(10(6-13)11(14)16)15-9-4-2-8(12)3-5-9/h2-5,10H,1H3,(H2,14,16) IHRMNAKCISORDF-UHFFFAOYSA-N 42640 (E)-2-cyano-3-(4-fluoroanilino)-2-butenamide::(E)-2-cyano-3-(4-fluoroanilino)but-2-enamide::(E)-2-cyano-3-[(4-fluorophenyl)amino]but-2-enamide::MLS000080846::SMR000042755::cid_662175 Mitogen-activated protein kinase 10 Homo sapiens 26710 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42640&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896543 252623332 51689 ZINC04325750 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79609 Oc1ccccc1-c1nc(NCCN2CCOCC2)c2ccccc2n1 InChI=1S/C20H22N4O2/c25-18-8-4-2-6-16(18)20-22-17-7-3-1-5-15(17)19(23-20)21-9-10-24-11-13-26-14-12-24/h1-8,25H,9-14H2,(H,21,22,23) XVAZSZOISVGIDR-UHFFFAOYSA-N 40955 (6E)-6-[4-(2-morpholin-4-ylethylamino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one::(6E)-6-[4-(2-morpholinoethylamino)-1H-quinazolin-2-ylidene]cyclohexa-2,4-dien-1-one::(6E)-6-[4-[2-(4-morpholinyl)ethylamino]-1H-quinazolin-2-ylidene]-1-cyclohexa-2,4-dienone::MLS000081087::SMR000042836::cid_5389468 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40955&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5389468 252621734 ZINC13127593 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79610 Fc1cccc(c1)C(=O)N1CCCC(C1)C(=O)N1CCCC1 InChI=1S/C17H21FN2O2/c18-15-7-3-5-13(11-15)16(21)20-10-4-6-14(12-20)17(22)19-8-1-2-9-19/h3,5,7,11,14H,1-2,4,6,8-10,12H2 GTFUNIQBBNAIKX-UHFFFAOYSA-N 42641 MLS000081334::SMR000042956::[1-(3-fluorobenzoyl)-3-piperidyl]-pyrrolidino-methanone::[1-(3-fluorobenzoyl)piperidin-3-yl]-pyrrolidin-1-ylmethanone::[1-(3-fluorophenyl)carbonylpiperidin-3-yl]-pyrrolidin-1-yl-methanone::[1-[(3-fluorophenyl)-oxomethyl]-3-piperidinyl]-(1-pyrrolidinyl)methanone::cid_662296 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42641&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 662296 252623333 ZINC00524792 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79611 CC(=NC1CCCC1)C(C#N)C(N)=O InChI=1S/C10H15N3O/c1-7(9(6-11)10(12)14)13-8-4-2-3-5-8/h8-9H,2-5H2,1H3,(H2,12,14) BVXGOSTVYGIIBJ-UHFFFAOYSA-N 42642 (E)-2-cyano-3-(cyclopentylamino)-2-butenamide::(E)-2-cyano-3-(cyclopentylamino)but-2-enamide::MLS000080847::SMR000043224::cid_662580 Mitogen-activated protein kinase 10 Homo sapiens 33350 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42642&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 6955713 252623334 51689 ZINC17748489 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79612 Brc1ccc(o1)-c1nn2c(nnc2s1)-c1ccco1 InChI=1S/C11H5BrN4O2S/c12-8-4-3-7(18-8)10-15-16-9(6-2-1-5-17-6)13-14-11(16)19-10/h1-5H SMGFRJZXRIDDIV-UHFFFAOYSA-N 42643 6-(5-bromanylfuran-2-yl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::6-(5-bromo-2-furanyl)-3-(2-furanyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::6-(5-bromo-2-furyl)-3-(2-furyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::6-(5-bromofuran-2-yl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole::MLS000041402::SMR000043609::cid_662886 Mitogen-activated protein kinase 10 Homo sapiens 58030 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42643&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 662886 252623335 ZINC00530804 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79613 N#CCCSc1ncnc2c3ccccc3oc12 InChI=1S/C13H9N3OS/c14-6-3-7-18-13-12-11(15-8-16-13)9-4-1-2-5-10(9)17-12/h1-2,4-5,8H,3,7H2 QZAOIIJMHYXTCZ-UHFFFAOYSA-N 42644 3-(4-benzofuro[3,2-d]pyrimidinylthio)propanenitrile::3-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)propanenitrile::3-(benzofuro[3,2-d]pyrimidin-4-ylthio)propionitrile::MLS000041717::SMR000044207::cid_663378 Mitogen-activated protein kinase 10 Homo sapiens 27740 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42644&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 663378 252623336 ZINC02400935 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79614 C(Sc1ncnc2c3ccccc3oc12)c1nc2ccccc2[nH]1 InChI=1S/C18H12N4OS/c1-4-8-14-11(5-1)16-17(23-14)18(20-10-19-16)24-9-15-21-12-6-2-3-7-13(12)22-15/h1-8,10H,9H2,(H,21,22) VXLSYPVPTOYMJS-UHFFFAOYSA-N 42645 4-(1H-benzimidazol-2-ylmethylsulfanyl)-[1]benzofuro[3,2-d]pyrimidine::4-(1H-benzimidazol-2-ylmethylthio)benzofuro[3,2-d]pyrimidine::MLS000082657::SMR000044303::cid_663661 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42645&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 663661 252623337 ZINC04039912 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79615 Cc1nn(-c2ccccc2C)c2sc(cc12)C(=O)NCc1cccnc1 InChI=1S/C20H18N4OS/c1-13-6-3-4-8-17(13)24-20-16(14(2)23-24)10-18(26-20)19(25)22-12-15-7-5-9-21-11-15/h3-11H,12H2,1-2H3,(H,22,25) IWAUERFHEPZPOP-UHFFFAOYSA-N 42646 3-methyl-1-(2-methylphenyl)-N-(3-pyridinylmethyl)-5-thieno[2,3-c]pyrazolecarboxamide::3-methyl-1-(2-methylphenyl)-N-(pyridin-3-ylmethyl)thieno[2,3-c]pyrazole-5-carboxamide::3-methyl-1-(o-tolyl)-N-(3-pyridylmethyl)thieno[2,3-c]pyrazole-5-carboxamide::MLS000082823::SMR000044689::cid_663824 Mitogen-activated protein kinase 10 Homo sapiens 10620 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42646&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 663824 252623338 ZINC02416271 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79616 Cc1nn(-c2ccccc2C)c2sc(cc12)C(=O)N1CCOCC1 InChI=1S/C18H19N3O2S/c1-12-5-3-4-6-15(12)21-18-14(13(2)19-21)11-16(24-18)17(22)20-7-9-23-10-8-20/h3-6,11H,7-10H2,1-2H3 GLIJECMQIQKGBS-UHFFFAOYSA-N 42647 MLS000082822::SMR000044696::[3-methyl-1-(2-methylphenyl)-5-thieno[2,3-c]pyrazolyl]-(4-morpholinyl)methanone::[3-methyl-1-(2-methylphenyl)thieno[2,3-c]pyrazol-5-yl]-morpholin-4-yl-methanone::[3-methyl-1-(2-methylphenyl)thieno[2,3-c]pyrazol-5-yl]-morpholin-4-ylmethanone::[3-methyl-1-(o-tolyl)thieno[2,3-c]pyrazol-5-yl]-morpholino-methanone::cid_663836 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42647&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 663836 252623339 ZINC00538618 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79617 O=C1c2ccccc2-c2onc3ccc(NCCCn4ccnc4)c1c23 InChI=1S/C20H16N4O2/c25-19-13-4-1-2-5-14(13)20-18-16(23-26-20)7-6-15(17(18)19)22-8-3-10-24-11-9-21-12-24/h1-2,4-7,9,11-12,22H,3,8,10H2 SIJFRVCYVJSYJY-UHFFFAOYSA-N 32050 MLS000080844::SMR000044769::cid_663844 Mitogen-activated protein kinase 10 Homo sapiens 22200 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32050&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 663844 242052851 ZINC02417895 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79618 Cc1ccc(cc1)C(=O)OCc1cc2ccccc2[nH]c1=O InChI=1S/C18H15NO3/c1-12-6-8-13(9-7-12)18(21)22-11-15-10-14-4-2-3-5-16(14)19-17(15)20/h2-10H,11H2,1H3,(H,19,20) HITKKSYBGXWNOF-UHFFFAOYSA-N 42648 (2-oxidanylidene-1H-quinolin-3-yl)methyl 4-methylbenzoate::(2-oxo-1H-quinolin-3-yl)methyl 4-methylbenzoate::4-methylbenzoic acid (2-keto-1H-quinolin-3-yl)methyl ester::4-methylbenzoic acid (2-oxo-1H-quinolin-3-yl)methyl ester::MLS000040475::SMR000044791::cid_663870 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42648&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 663870 252623340 ZINC08666682 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79619 CC(C)Oc1ccc(cc1)C1C(C(=O)c2ccc(C)o2)C(=O)C(=O)N1CCCn1ccnc1 InChI=1S/C25H27N3O5/c1-16(2)32-19-8-6-18(7-9-19)22-21(23(29)20-10-5-17(3)33-20)24(30)25(31)28(22)13-4-12-27-14-11-26-15-27/h5-11,14-16,21-22H,4,12-13H2,1-3H3 MWWMDOGNYUXOPX-UHFFFAOYSA-N 37665 1-(3-imidazol-1-ylpropyl)-3-(5-methylfuran-2-yl)carbonyl-4-oxidanyl-2-(4-propan-2-yloxyphenyl)-2H-pyrrol-5-one::3-hydroxy-1-(3-imidazol-1-ylpropyl)-5-(4-isopropoxyphenyl)-4-(5-methyl-2-furoyl)-3-pyrrolin-2-one::4-hydroxy-1-(3-imidazol-1-ylpropyl)-3-(5-methylfuran-2-carbonyl)-2-(4-propan-2-yloxyphenyl)-2H-pyrrol-5-one::4-hydroxy-1-[3-(1-imidazolyl)propyl]-3-[(5-methyl-2-furanyl)-oxomethyl]-2-(4-propan-2-yloxyphenyl)-2H-pyrrol-5-one::MLS000040700::SMR000044770::cid_663879 Mitogen-activated protein kinase 10 Homo sapiens 37360 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37665&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896318 252618632 ZINC09177342 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79620 O=c1n(CCCn2ccnc2)c(nc2ccccc12)-c1ccco1 InChI=1S/C18H16N4O2/c23-18-14-5-1-2-6-15(14)20-17(16-7-3-12-24-16)22(18)10-4-9-21-11-8-19-13-21/h1-3,5-8,11-13H,4,9-10H2 SMRWPOHCHCSTFU-UHFFFAOYSA-N 42649 2-(2-furanyl)-3-[3-(1-imidazolyl)propyl]-4-quinazolinone::2-(2-furyl)-3-(3-imidazol-1-ylpropyl)quinazolin-4-one::2-(furan-2-yl)-3-(3-imidazol-1-ylpropyl)quinazolin-4-one::MLS000040502::SMR000044662::cid_663919 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42649&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 663919 252623341 ZINC00538239 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79621 Cc1ccc2c(C)nc(NC3=NCN(Cc4ccccc4)CN3)nc2c1 InChI=1S/C20H22N6/c1-14-8-9-17-15(2)23-20(24-18(17)10-14)25-19-21-12-26(13-22-19)11-16-6-4-3-5-7-16/h3-10H,11-13H2,1-2H3,(H2,21,22,23,24,25) QRYRNXKRJZALDG-UHFFFAOYSA-N 42650 (3-benzyl-2,4-dihydro-1H-s-triazin-6-yl)-(4,7-dimethylquinazolin-2-yl)amine::4,7-dimethyl-N-[3-(phenylmethyl)-2,4-dihydro-1H-1,3,5-triazin-6-yl]-2-quinazolinamine::4,7-dimethyl-N-[3-(phenylmethyl)-2,4-dihydro-1H-1,3,5-triazin-6-yl]quinazolin-2-amine::MLS000080506::N-(3-benzyl-2,4-dihydro-1H-1,3,5-triazin-6-yl)-4,7-dimethylquinazolin-2-amine::SMR000037452::cid_664197 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42650&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 664197 252623342 ZINC19324291 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79622 Cc1nc(NCc2ccco2)c(C#N)c2CC(C)(C)OCc12 InChI=1S/C17H19N3O2/c1-11-15-10-22-17(2,3)7-13(15)14(8-18)16(20-11)19-9-12-5-4-6-21-12/h4-6H,7,9-10H2,1-3H3,(H,19,20) DXWJCQUICVAIDC-UHFFFAOYSA-N 42651 6-(2-furanylmethylamino)-3,3,8-trimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile::6-(2-furfurylamino)-3,3,8-trimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile::6-(furan-2-ylmethylamino)-3,3,8-trimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile::MLS000039886::SMR000045485::cid_664448 Mitogen-activated protein kinase 10 Homo sapiens 37530 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42651&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 664448 252623343 ZINC20438159 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79623 CCOC(=O)CC(=O)CSc1ncnc2c3ccccc3oc12 InChI=1S/C16H14N2O4S/c1-2-21-13(20)7-10(19)8-23-16-15-14(17-9-18-16)11-5-3-4-6-12(11)22-15/h3-6,9H,2,7-8H2,1H3 GVICDJHRPLLWEN-UHFFFAOYSA-N 42652 4-(4-benzofuro[3,2-d]pyrimidinylthio)-3-oxobutanoic acid ethyl ester::4-(benzofuro[3,2-d]pyrimidin-4-ylthio)-3-keto-butyric acid ethyl ester::MLS000041716::SMR000045499::cid_664514::ethyl 4-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-3-oxidanylidene-butanoate::ethyl 4-([1]benzofuro[3,2-d]pyrimidin-4-ylsulfanyl)-3-oxobutanoate Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42652&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 664514 252623344 ZINC02420086 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79624 COc1ccc(cc1)-c1cnc(N)nc1-c1ccc(OCC(C)=C)cc1O InChI=1S/C21H21N3O3/c1-13(2)12-27-16-8-9-17(19(25)10-16)20-18(11-23-21(22)24-20)14-4-6-15(26-3)7-5-14/h4-11,25H,1,12H2,2-3H3,(H2,22,23,24) APRGBLOXXLPHPL-UHFFFAOYSA-N 42653 (6E)-6-[2-amino-5-(4-methoxyphenyl)-1H-pyrimidin-6-ylidene]-3-(2-methylallyloxy)cyclohexa-2,4-dien-1-one::(6E)-6-[2-amino-5-(4-methoxyphenyl)-1H-pyrimidin-6-ylidene]-3-(2-methylprop-2-enoxy)-1-cyclohexa-2,4-dienone::(6E)-6-[2-amino-5-(4-methoxyphenyl)-1H-pyrimidin-6-ylidene]-3-(2-methylprop-2-enoxy)cyclohexa-2,4-dien-1-one::(6E)-6-[2-azanyl-5-(4-methoxyphenyl)-1H-pyrimidin-6-ylidene]-3-(2-methylprop-2-enoxy)cyclohexa-2,4-dien-1-one::MLS000083257::SMR000046524::cid_5389930 Mitogen-activated protein kinase 10 Homo sapiens 29440 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42653&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5389930 252623345 ZINC13127203 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79625 COc1ccc(C=Nn2c(N)nc3ccccc23)cc1OC InChI=1S/C16H16N4O2/c1-21-14-8-7-11(9-15(14)22-2)10-18-20-13-6-4-3-5-12(13)19-16(20)17/h3-10H,1-2H3,(H2,17,19) FNHJFFIDPOCPBP-UHFFFAOYSA-N 42654 1-[(3,4-dimethoxyphenyl)methylideneamino]-2-benzimidazolamine::1-[(3,4-dimethoxyphenyl)methylideneamino]benzimidazol-2-amine::MLS000083294::SMR000046583::[1-(veratrylideneamino)benzimidazol-2-yl]amine::cid_665491 Mitogen-activated protein kinase 10 Homo sapiens 16610 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42654&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 7008172 252623346 ZINC02336383 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79626 CCC1S\C(N(C1=O)c1ccc(F)cc1)=C(/C#N)C(N)=O InChI=1S/C14H12FN3O2S/c1-2-11-13(20)18(9-5-3-8(15)4-6-9)14(21-11)10(7-16)12(17)19/h3-6,11H,2H2,1H3,(H2,17,19)/b14-10+ PNGUYBLNBKYBDN-GXDHUFHOSA-N 42655 (2E)-2-cyano-2-[5-ethyl-3-(4-fluorophenyl)-4-keto-thiazolidin-2-ylidene]acetamide::(2E)-2-cyano-2-[5-ethyl-3-(4-fluorophenyl)-4-oxidanylidene-1,3-thiazolidin-2-ylidene]ethanamide::(2E)-2-cyano-2-[5-ethyl-3-(4-fluorophenyl)-4-oxo-1,3-thiazolidin-2-ylidene]acetamide::(2E)-2-cyano-2-[5-ethyl-3-(4-fluorophenyl)-4-oxo-2-thiazolidinylidene]acetamide::MLS000041598::SMR000046612::cid_665552 Mitogen-activated protein kinase 10 Homo sapiens 32610 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42655&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 665552 252623347 ZINC02372879 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79627 Clc1cccc2[nH]c3c(ncn(Cc4ccncc4)c3=O)c12 InChI=1S/C16H11ClN4O/c17-11-2-1-3-12-13(11)14-15(20-12)16(22)21(9-19-14)8-10-4-6-18-7-5-10/h1-7,9,20H,8H2 FPIOLRWPCKPVKQ-UHFFFAOYSA-N 42656 9-chloranyl-3-(pyridin-4-ylmethyl)-5H-pyrimido[5,4-b]indol-4-one::9-chloro-3-(4-pyridylmethyl)-5H-pyrimid[5,4-b]indol-4-one::9-chloro-3-(pyridin-4-ylmethyl)-5H-pyrimido[5,4-b]indol-4-one::MLS000082943::SMR000046821::cid_665628 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42656&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 665628 252623348 ZINC08579948 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79628 COc1ccc(cc1)-c1cnc(N)nc1-c1ccc(OC)cc1O InChI=1S/C18H17N3O3/c1-23-12-5-3-11(4-6-12)15-10-20-18(19)21-17(15)14-8-7-13(24-2)9-16(14)22/h3-10,22H,1-2H3,(H2,19,20,21) CKQBIKHXMSBFTE-UHFFFAOYSA-N 40958 (6E)-6-[2-amino-5-(4-methoxyphenyl)-1H-pyrimidin-6-ylidene]-3-methoxy-1-cyclohexa-2,4-dienone::(6E)-6-[2-amino-5-(4-methoxyphenyl)-1H-pyrimidin-6-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one::(6E)-6-[2-amino-5-(4-methoxyphenyl)-1H-pyrimidin-6-ylidene]-3-methoxycyclohexa-2,4-dien-1-one::(6E)-6-[2-azanyl-5-(4-methoxyphenyl)-1H-pyrimidin-6-ylidene]-3-methoxy-cyclohexa-2,4-dien-1-one::MLS000083254::SMR000047009::cid_5389961 Mitogen-activated protein kinase 10 Homo sapiens 19910 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40958&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5389961 252621737 ZINC13127145 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79629 Nc1c(C(=O)NCc2ccc3OCOc3c2)c2nc3ccccc3nc2n1-c1ccc(N)cc1 InChI=1S/C25H20N6O3/c26-15-6-8-16(9-7-15)31-23(27)21(22-24(31)30-18-4-2-1-3-17(18)29-22)25(32)28-12-14-5-10-19-20(11-14)34-13-33-19/h1-11H,12-13,26-27H2,(H,28,32) ATSXLKSULBDODD-UHFFFAOYSA-N 42657 1-(4-aminophenyl)-2-azanyl-N-(1,3-benzodioxol-5-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-1-(4-aminophenyl)-N-(1,3-benzodioxol-5-ylmethyl)-3-pyrrolo[3,2-b]quinoxalinecarboxamide::2-amino-1-(4-aminophenyl)-N-(1,3-benzodioxol-5-ylmethyl)pyrrolo[3,2-b]quinoxaline-3-carboxamide::2-amino-1-(4-aminophenyl)-N-piperonyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide::MLS000083872::SMR000047077::cid_665762 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42657&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 665762 252623349 ZINC04295346 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79630 CC1CCc2nc(N)c(C#N)c(-c3ccncc3)c2C1 InChI=1S/C16H16N4/c1-10-2-3-14-12(8-10)15(11-4-6-19-7-5-11)13(9-17)16(18)20-14/h4-7,10H,2-3,8H2,1H3,(H2,18,20) LIKHXLCMRMLWIA-UHFFFAOYSA-N 42658 2-amino-6-methyl-4-(4-pyridyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-amino-6-methyl-4-pyridin-4-yl-5,6,7,8-tetrahydroquinoline-3-carbonitrile::2-azanyl-6-methyl-4-pyridin-4-yl-5,6,7,8-tetrahydroquinoline-3-carbonitrile::MLS000082829::SMR000047123::cid_665768 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42658&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 665768 252623350 ZINC20503048 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79631 COc1ccc2n(C)c3c(ncn(Cc4ccco4)c3=O)c2c1 InChI=1S/C17H15N3O3/c1-19-14-6-5-11(22-2)8-13(14)15-16(19)17(21)20(10-18-15)9-12-4-3-7-23-12/h3-8,10H,9H2,1-2H3 JMFUQJLROULNKY-UHFFFAOYSA-N 37893 3-(2-furanylmethyl)-8-methoxy-5-methyl-4-pyrimido[5,4-b]indolone::3-(2-furfuryl)-8-methoxy-5-methyl-pyrimid[5,4-b]indol-4-one::3-(furan-2-ylmethyl)-8-methoxy-5-methyl-pyrimido[5,4-b]indol-4-one::3-(furan-2-ylmethyl)-8-methoxy-5-methylpyrimido[5,4-b]indol-4-one::MLS000042190::SMR000047233::cid_665933 Mitogen-activated protein kinase 10 Homo sapiens 89960 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37893&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 665933 252618849 ZINC02438300 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79632 O=C1C(C(=O)c2ccccc12)c1ccncc1 InChI=1S/C14H9NO2/c16-13-10-3-1-2-4-11(10)14(17)12(13)9-5-7-15-8-6-9/h1-8,12H XSPDDUQLHWGPSP-UHFFFAOYSA-N 42659 2-(1H-pyridin-4-ylidene)indane-1,3-quinone::2-(1H-pyridin-4-ylidene)indene-1,3-dione::2-(4-pyridyl)indane-1,3-quinone::MLS000039587::SMR000038130::cid_5389994 Mitogen-activated protein kinase 10 Homo sapiens 6691 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42659&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 694901 252623351 ZINC00156742 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79633 Cc1c(oc2ccccc12)-c1nc(N)nc(Nc2ccccc2)n1 InChI=1S/C18H15N5O/c1-11-13-9-5-6-10-14(13)24-15(11)16-21-17(19)23-18(22-16)20-12-7-3-2-4-8-12/h2-10H,1H3,(H3,19,20,21,22,23) WNOJMYQYKBXNCP-UHFFFAOYSA-N 42660 6-(3-methyl-1-benzofuran-2-yl)-2-N-phenyl-1,3,5-triazine-2,4-diamine::6-(3-methyl-1-benzofuran-2-yl)-N2-phenyl-1,3,5-triazine-2,4-diamine::6-(3-methyl-2-benzofuranyl)-N2-phenyl-1,3,5-triazine-2,4-diamine::MLS000080580::SMR000037465::[4-amino-6-(3-methylbenzofuran-2-yl)-s-triazin-2-yl]-phenyl-amine::cid_666284 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42660&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 666284 252623352 ZINC17015026 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79634 CN1CC2(Cc3cc(C)ccc13)C(=O)OC1(CCCCC1)OC2=O InChI=1S/C19H23NO4/c1-13-6-7-15-14(10-13)11-18(12-20(15)2)16(21)23-19(24-17(18)22)8-4-3-5-9-19/h6-7,10H,3-5,8-9,11-12H2,1-2H3 WGLRIUQXIGIPDK-UHFFFAOYSA-N 33527 MLS000042487::SMR000047486::cid_666291 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33527&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 666291 242052874 ZINC02202851 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79635 CCOc1ccc(c(O)c1)-c1nc(N)ncc1-c1ccccc1 InChI=1S/C18H17N3O2/c1-2-23-13-8-9-14(16(22)10-13)17-15(11-20-18(19)21-17)12-6-4-3-5-7-12/h3-11,22H,2H2,1H3,(H2,19,20,21) FHRLCCBVWMQEFD-UHFFFAOYSA-N 42661 (6Z)-6-(2-amino-5-phenyl-1H-pyrimidin-6-ylidene)-3-ethoxy-1-cyclohexa-2,4-dienone::(6Z)-6-(2-amino-5-phenyl-1H-pyrimidin-6-ylidene)-3-ethoxy-cyclohexa-2,4-dien-1-one::(6Z)-6-(2-amino-5-phenyl-1H-pyrimidin-6-ylidene)-3-ethoxycyclohexa-2,4-dien-1-one::(6Z)-6-(2-azanyl-5-phenyl-1H-pyrimidin-6-ylidene)-3-ethoxy-cyclohexa-2,4-dien-1-one::MLS000042426::SMR000047772::cid_5390022 Mitogen-activated protein kinase 10 Homo sapiens 12680 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42661&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5390022 252623353 ZINC13127053 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79636 COC(=O)c1ccccc1NC(=O)CSc1ccccn1 InChI=1S/C15H14N2O3S/c1-20-15(19)11-6-2-3-7-12(11)17-13(18)10-21-14-8-4-5-9-16-14/h2-9H,10H2,1H3,(H,17,18) RQXRZTHBHUMLKF-UHFFFAOYSA-N 42662 2-[[1-oxo-2-(2-pyridinylthio)ethyl]amino]benzoic acid methyl ester::2-[[2-(2-pyridylthio)acetyl]amino]benzoic acid methyl ester::MLS000080601::SMR000034995::cid_667093::methyl 2-(2-pyridin-2-ylsulfanylethanoylamino)benzoate::methyl 2-[(2-pyridin-2-ylsulfanylacetyl)amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 35300 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42662&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 667093 252623354 ZINC00249996 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79637 COC(=O)c1ccccc1NC(=O)COC(=O)CSCC(=O)N1CCOCC1 InChI=1S/C18H22N2O7S/c1-25-18(24)13-4-2-3-5-14(13)19-15(21)10-27-17(23)12-28-11-16(22)20-6-8-26-9-7-20/h2-5H,6-12H2,1H3,(H,19,21) WJAVPRUMABWSPY-UHFFFAOYSA-N 42663 2-[[2-[2-[(2-keto-2-morpholino-ethyl)thio]acetyl]oxyacetyl]amino]benzoic acid methyl ester::2-[[2-[2-[[2-(4-morpholinyl)-2-oxoethyl]thio]-1-oxoethoxy]-1-oxoethyl]amino]benzoic acid methyl ester::MLS000057499::SMR000064121::cid_2997530::methyl 2-[2-[2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)sulfanylethanoyloxy]ethanoylamino]benzoate::methyl 2-[[2-[2-(2-morpholin-4-yl-2-oxoethyl)sulfanylacetyl]oxyacetyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42663&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2997530 252623355 ZINC04195452 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79638 COc1cc(ccc1OCc1c(C)noc1C)C(=O)Nc1nccs1 InChI=1S/C17H17N3O4S/c1-10-13(11(2)24-20-10)9-23-14-5-4-12(8-15(14)22-3)16(21)19-17-18-6-7-25-17/h4-8H,9H2,1-3H3,(H,18,19,21) JEGWQZMDHIJTEL-UHFFFAOYSA-N 42664 4-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-3-methoxy-N-(1,3-thiazol-2-yl)benzamide::4-[(3,5-dimethyl-4-isoxazolyl)methoxy]-3-methoxy-N-(2-thiazolyl)benzamide::4-[(3,5-dimethylisoxazol-4-yl)methoxy]-3-methoxy-N-thiazol-2-yl-benzamide::MLS000057859::SMR000065205::cid_2666526 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42664&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2666526 252623356 ZINC03549607 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79639 NC(=O)c1ccsc1NC(=O)CSc1nc2ccccc2c(=O)n1CCCO InChI=1S/C18H18N4O4S2/c19-15(25)12-6-9-27-16(12)21-14(24)10-28-18-20-13-5-2-1-4-11(13)17(26)22(18)7-3-8-23/h1-2,4-6,9,23H,3,7-8,10H2,(H2,19,25)(H,21,24) XIDZPFUUHWAPJO-UHFFFAOYSA-N 42665 2-[2-[4-oxidanylidene-3-(3-oxidanylpropyl)quinazolin-2-yl]sulfanylethanoylamino]thiophene-3-carboxamide::2-[[2-[3-(3-hydroxypropyl)-4-oxoquinazolin-2-yl]sulfanylacetyl]amino]thiophene-3-carboxamide::2-[[2-[[3-(3-hydroxypropyl)-4-keto-quinazolin-2-yl]thio]acetyl]amino]thiophene-3-carboxamide::2-[[2-[[3-(3-hydroxypropyl)-4-oxo-2-quinazolinyl]thio]-1-oxoethyl]amino]-3-thiophenecarboxamide::MLS000098565::SMR000065396::cid_2575371 Mitogen-activated protein kinase 10 Homo sapiens 7190 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42665&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2575371 252623357 ZINC03455026 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79640 Cc1ccc2c(CC(=O)Nc3sccc3C(N)=O)coc2c1 InChI=1S/C16H14N2O3S/c1-9-2-3-11-10(8-21-13(11)6-9)7-14(19)18-16-12(15(17)20)4-5-22-16/h2-6,8H,7H2,1H3,(H2,17,20)(H,18,19) HEDGMIFPYLNAQJ-UHFFFAOYSA-N 42666 2-[2-(6-methyl-1-benzofuran-3-yl)ethanoylamino]thiophene-3-carboxamide::2-[[2-(6-methyl-1-benzofuran-3-yl)acetyl]amino]thiophene-3-carboxamide::2-[[2-(6-methyl-3-benzofuranyl)-1-oxoethyl]amino]-3-thiophenecarboxamide::2-[[2-(6-methylbenzofuran-3-yl)acetyl]amino]thiophene-3-carboxamide::MLS000098225::SMR000066915::cid_2115913 Mitogen-activated protein kinase 10 Homo sapiens 20930 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42666&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2115913 252623358 ZINC02652566 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79641 CCOc1ccc(cc1Cn1nc(C(O)=O)c2ccccc2c1=O)C(C)=O InChI=1S/C20H18N2O5/c1-3-27-17-9-8-13(12(2)23)10-14(17)11-22-19(24)16-7-5-4-6-15(16)18(21-22)20(25)26/h4-10H,3,11H2,1-2H3,(H,25,26) BFVJTNBTNGRYFI-UHFFFAOYSA-N 42667 3-(5-acetyl-2-ethoxy-benzyl)-4-keto-phthalazine-1-carboxylic acid::3-[(5-acetyl-2-ethoxyphenyl)methyl]-4-oxo-1-phthalazinecarboxylic acid::3-[(5-acetyl-2-ethoxyphenyl)methyl]-4-oxophthalazine-1-carboxylic acid::3-[(5-ethanoyl-2-ethoxy-phenyl)methyl]-4-oxidanylidene-phthalazine-1-carboxylic acid::MLS000098717::SMR000063753::cid_2124488 Mitogen-activated protein kinase 10 Homo sapiens 35920 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42667&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2124488 252623359 ZINC02660614 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79642 CCc1cc2c(nc(SCC(=O)C(C#N)C(C)=N)n(CC=C)c2=O)s1 InChI=1S/C17H18N4O2S2/c1-4-6-21-16(23)12-7-11(5-2)25-15(12)20-17(21)24-9-14(22)13(8-18)10(3)19/h4,7,13,19H,1,5-6,9H2,2-3H3 CDNDGZCNMXYAIN-UHFFFAOYSA-N 42668 (E)-2-[2-[(3-allyl-6-ethyl-4-keto-thieno[2,3-d]pyrimidin-2-yl)thio]acetyl]-3-amino-but-2-enenitrile::(E)-3-amino-2-[2-(6-ethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetyl]but-2-enenitrile::(E)-3-amino-2-[2-[(6-ethyl-4-oxo-3-prop-2-enyl-2-thieno[2,3-d]pyrimidinyl)thio]-1-oxoethyl]-2-butenenitrile::(E)-3-azanyl-2-[2-(6-ethyl-4-oxidanylidene-3-prop-2-enyl-thieno[2,3-d]pyrimidin-2-yl)sulfanylethanoyl]but-2-enenitrile::MLS000058190::SMR000063280::cid_5742460 Mitogen-activated protein kinase 10 Homo sapiens 61460 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42668&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 40619699 252623360 51689 ZINC87711562 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79643 Cc1cc(NC(=O)COC(=O)c2n[nH]c3ccccc23)no1 InChI=1S/C14H12N4O4/c1-8-6-11(18-22-8)15-12(19)7-21-14(20)13-9-4-2-3-5-10(9)16-17-13/h2-6H,7H2,1H3,(H,16,17)(H,15,18,19) RDFQLMLGLQFELN-UHFFFAOYSA-N 42669 1H-indazole-3-carboxylic acid [2-[(5-methyl-3-isoxazolyl)amino]-2-oxoethyl] ester::1H-indazole-3-carboxylic acid [2-keto-2-[(5-methylisoxazol-3-yl)amino]ethyl] ester::MLS000053376::SMR000063360::[2-[(5-methyl-1,2-oxazol-3-yl)amino]-2-oxidanylidene-ethyl] 1H-indazole-3-carboxylate::[2-[(5-methyl-1,2-oxazol-3-yl)amino]-2-oxoethyl] 1H-indazole-3-carboxylate::cid_2098304 Mitogen-activated protein kinase 10 Homo sapiens 62730 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42669&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2098304 252623361 ZINC05075033 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79644 COc1cc(CC(=O)Nc2ncc(C)s2)cc(OC)c1OC InChI=1S/C15H18N2O4S/c1-9-8-16-15(22-9)17-13(18)7-10-5-11(19-2)14(21-4)12(6-10)20-3/h5-6,8H,7H2,1-4H3,(H,16,17,18) HLHOLHHDNVDQRZ-UHFFFAOYSA-N 42670 MLS000053248::N-(5-methyl-1,3-thiazol-2-yl)-2-(3,4,5-trimethoxyphenyl)acetamide::N-(5-methyl-1,3-thiazol-2-yl)-2-(3,4,5-trimethoxyphenyl)ethanamide::N-(5-methyl-2-thiazolyl)-2-(3,4,5-trimethoxyphenyl)acetamide::N-(5-methylthiazol-2-yl)-2-(3,4,5-trimethoxyphenyl)acetamide::SMR000067557::cid_2091162 Mitogen-activated protein kinase 10 Homo sapiens 13350 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42670&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2091162 252623362 ZINC02628787 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79645 COc1ccc2nc(NC(=O)Cc3ccc(OC)c(c3)S(=O)(=O)N3CCOCC3)sc2c1 InChI=1S/C21H23N3O6S2/c1-28-15-4-5-16-18(13-15)31-21(22-16)23-20(25)12-14-3-6-17(29-2)19(11-14)32(26,27)24-7-9-30-10-8-24/h3-6,11,13H,7-10,12H2,1-2H3,(H,22,23,25) SHUSGGHHKYPGSV-UHFFFAOYSA-N 42671 MLS000060363::N-(6-methoxy-1,3-benzothiazol-2-yl)-2-(4-methoxy-3-morpholin-4-ylsulfonyl-phenyl)ethanamide::N-(6-methoxy-1,3-benzothiazol-2-yl)-2-(4-methoxy-3-morpholin-4-ylsulfonylphenyl)acetamide::N-(6-methoxy-1,3-benzothiazol-2-yl)-2-(4-methoxy-3-morpholinosulfonyl-phenyl)acetamide::N-(6-methoxy-1,3-benzothiazol-2-yl)-2-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]acetamide::SMR000067210::cid_2079985 Mitogen-activated protein kinase 10 Homo sapiens 28150 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42671&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2079985 252623363 ZINC02618099 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79646 NC(=O)c1c(NC(=O)Cc2cccs2)sc2CCCc12 InChI=1S/C14H14N2O2S2/c15-13(18)12-9-4-1-5-10(9)20-14(12)16-11(17)7-8-3-2-6-19-8/h2-3,6H,1,4-5,7H2,(H2,15,18)(H,16,17) DCXPHSZGIVQNHS-UHFFFAOYSA-N 42672 2-(2-thiophen-2-ylethanoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::2-[(1-oxo-2-thiophen-2-ylethyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::2-[(2-thiophen-2-ylacetyl)amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::2-[[2-(2-thienyl)acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::MLS000058659::SMR000066893::cid_2115372 Mitogen-activated protein kinase 10 Homo sapiens 28320 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42672&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2115372 252623364 ZINC02652042 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79647 CC1=C(C)CS(=O)N(C1)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C12H14ClNO3S2/c1-9-7-14(18(15)8-10(9)2)19(16,17)12-5-3-11(13)4-6-12/h3-6H,7-8H2,1-2H3 SBLYSFKKDRQLIT-UHFFFAOYSA-N 35500 2-(4-chlorophenyl)sulfonyl-4,5-dimethyl-3,6-dihydro-1,2-thiazine 1-oxide::2-(4-chlorophenyl)sulfonyl-4,5-dimethyl-3,6-dihydrothiazine 1-oxide::MLS000048879::SMR000061427::cid_794694 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35500&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 794694 252617764 ZINC05103484 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79648 CCc1ccc2c(COC(=O)c3n[nH]c4ccccc34)cc(=O)oc2c1 InChI=1S/C20H16N2O4/c1-2-12-7-8-14-13(10-18(23)26-17(14)9-12)11-25-20(24)19-15-5-3-4-6-16(15)21-22-19/h3-10H,2,11H2,1H3,(H,21,22) MTRXEAWWUVQIAA-UHFFFAOYSA-N 36981 (7-ethyl-2-oxidanylidene-chromen-4-yl)methyl 1H-indazole-3-carboxylate::(7-ethyl-2-oxochromen-4-yl)methyl 1H-indazole-3-carboxylate::1H-indazole-3-carboxylic acid (7-ethyl-2-keto-chromen-4-yl)methyl ester::1H-indazole-3-carboxylic acid (7-ethyl-2-oxo-1-benzopyran-4-yl)methyl ester::MLS000058614::SMR000068210::cid_2998329 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36981&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2998329 252617953 ZINC23508364 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79649 COc1ccc(COC(=O)c2n[nH]c3ccccc23)cc1F InChI=1S/C16H13FN2O3/c1-21-14-7-6-10(8-12(14)17)9-22-16(20)15-11-4-2-3-5-13(11)18-19-15/h2-8H,9H2,1H3,(H,18,19) JGAGCSGFWHGMQC-UHFFFAOYSA-N 42673 (3-fluoranyl-4-methoxy-phenyl)methyl 1H-indazole-3-carboxylate::(3-fluoro-4-methoxyphenyl)methyl 1H-indazole-3-carboxylate::1H-indazole-3-carboxylic acid (3-fluoro-4-methoxy-benzyl) ester::1H-indazole-3-carboxylic acid (3-fluoro-4-methoxyphenyl)methyl ester::MLS000098931::SMR000063873::cid_2126218 Mitogen-activated protein kinase 10 Homo sapiens 11410 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42673&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2126218 252623365 ZINC04036623 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79650 COc1cc(CC(=O)Nc2nccs2)cc(OC)c1OC InChI=1S/C14H16N2O4S/c1-18-10-6-9(7-11(19-2)13(10)20-3)8-12(17)16-14-15-4-5-21-14/h4-7H,8H2,1-3H3,(H,15,16,17) ZZJAGDSXYXZYKL-UHFFFAOYSA-N 42674 MLS000058383::N-(1,3-thiazol-2-yl)-2-(3,4,5-trimethoxyphenyl)acetamide::N-(1,3-thiazol-2-yl)-2-(3,4,5-trimethoxyphenyl)ethanamide::N-(2-thiazolyl)-2-(3,4,5-trimethoxyphenyl)acetamide::N-thiazol-2-yl-2-(3,4,5-trimethoxyphenyl)acetamide::SMR000064048::cid_2083475 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42674&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2083475 252623366 ZINC02621587 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79651 Brc1ccc(o1)C(=O)Nc1nccs1 InChI=1S/C8H5BrN2O2S/c9-6-2-1-5(13-6)7(12)11-8-10-3-4-14-8/h1-4H,(H,10,11,12) TWEONBLONCCVLM-UHFFFAOYSA-N 42675 5-bromanyl-N-(1,3-thiazol-2-yl)furan-2-carboxamide::5-bromo-N-(1,3-thiazol-2-yl)furan-2-carboxamide::5-bromo-N-(2-thiazolyl)-2-furancarboxamide::5-bromo-N-thiazol-2-yl-2-furamide::MLS000057874::SMR000065046::cid_839812 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42675&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 839812 252623367 ZINC00368337 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79652 O=C(C(C#N)c1ccccn1)c1ccco1 InChI=1S/C12H8N2O2/c13-8-9(10-4-1-2-6-14-10)12(15)11-5-3-7-16-11/h1-7,9H QSDNWEJECKQAQI-UHFFFAOYSA-N 42676 (2Z)-3-(2-furanyl)-3-oxo-2-(1H-pyridin-2-ylidene)propanenitrile::(2Z)-3-(2-furyl)-3-keto-2-(1H-pyridin-2-ylidene)propionitrile::(2Z)-3-(furan-2-yl)-3-oxidanylidene-2-(1H-pyridin-2-ylidene)propanenitrile::(2Z)-3-(furan-2-yl)-3-oxo-2-(1H-pyridin-2-ylidene)propanenitrile::MLS000060631::SMR000062350::cid_5680363 Mitogen-activated protein kinase 10 Homo sapiens 51890 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42676&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2999156 252623368 ZINC03274030 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79653 COc1ccc(CC(=O)Nc2nc3ccccc3s2)cc1S(=O)(=O)N1CCOCC1 InChI=1S/C20H21N3O5S2/c1-27-16-7-6-14(12-18(16)30(25,26)23-8-10-28-11-9-23)13-19(24)22-20-21-15-4-2-3-5-17(15)29-20/h2-7,12H,8-11,13H2,1H3,(H,21,22,24) FPYNWKVXMOTTSD-UHFFFAOYSA-N 42677 MLS000053999::N-(1,3-benzothiazol-2-yl)-2-(4-methoxy-3-morpholin-4-ylsulfonyl-phenyl)ethanamide::N-(1,3-benzothiazol-2-yl)-2-(4-methoxy-3-morpholin-4-ylsulfonylphenyl)acetamide::N-(1,3-benzothiazol-2-yl)-2-(4-methoxy-3-morpholinosulfonyl-phenyl)acetamide::N-(1,3-benzothiazol-2-yl)-2-[4-methoxy-3-(4-morpholinylsulfonyl)phenyl]acetamide::SMR000063815::cid_2124987 Mitogen-activated protein kinase 10 Homo sapiens 24740 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42677&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2124987 252623369 ZINC02661073 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79654 COc1cc(CC(=O)Nc2sccc2C(N)=O)cc(OC)c1OC InChI=1S/C16H18N2O5S/c1-21-11-6-9(7-12(22-2)14(11)23-3)8-13(19)18-16-10(15(17)20)4-5-24-16/h4-7H,8H2,1-3H3,(H2,17,20)(H,18,19) XRYHWBQNTJUJLS-UHFFFAOYSA-N 42678 2-[2-(3,4,5-trimethoxyphenyl)ethanoylamino]thiophene-3-carboxamide::2-[[1-oxo-2-(3,4,5-trimethoxyphenyl)ethyl]amino]-3-thiophenecarboxamide::2-[[2-(3,4,5-trimethoxyphenyl)acetyl]amino]thiophene-3-carboxamide::MLS000053246::SMR000067555::cid_2091134 Mitogen-activated protein kinase 10 Homo sapiens 5942 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42678&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2091134 252623370 ZINC02628760 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79655 O=c1cc(nc2[nH]c3ccccc3n12)-c1ccccc1 InChI=1S/C16H11N3O/c20-15-10-13(11-6-2-1-3-7-11)18-16-17-12-8-4-5-9-14(12)19(15)16/h1-10H,(H,17,18) BBERZJLEIXBTKK-UHFFFAOYSA-N 42679 2-phenyl-1H-pyrimido[1,2-a]benzimidazol-4-one::MLS000058336::SMR000063490::cid_930735 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42679&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 930735 252623371 ZINC17778047 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79656 CCN(CC)S(=O)(=O)c1ccc2nc(COC(=O)c3n[nH]c4ccccc34)[nH]c2c1 InChI=1S/C20H21N5O4S/c1-3-25(4-2)30(27,28)13-9-10-16-17(11-13)22-18(21-16)12-29-20(26)19-14-7-5-6-8-15(14)23-24-19/h5-11H,3-4,12H2,1-2H3,(H,21,22)(H,23,24) IDBUYBIWHUUWRC-UHFFFAOYSA-N 42680 1H-indazole-3-carboxylic acid [6-(diethylsulfamoyl)-1H-benzimidazol-2-yl]methyl ester::MLS000053400::SMR000063379::[6-(diethylsulfamoyl)-1H-benzimidazol-2-yl]methyl 1H-indazole-3-carboxylate::cid_2099071 Mitogen-activated protein kinase 10 Homo sapiens 401 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42680&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2099071 252623372 ZINC87711563 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79657 Cc1nn(c2Sc3nc4ccccc4n3C(O)c12)-c1ccccc1 InChI=1S/C18H14N4OS/c1-11-15-16(23)21-14-10-6-5-9-13(14)19-18(21)24-17(15)22(20-11)12-7-3-2-4-8-12/h2-10,16,23H,1H3 SBMNGBYQULPGSK-UHFFFAOYSA-N 38587 MLS000081954::SMR000060148::cid_2999191 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38587&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2999191 242052949 ZINC00405958 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79658 COc1ccc(CC(=O)Nc2nc(C)cs2)cc1OC InChI=1S/C14H16N2O3S/c1-9-8-20-14(15-9)16-13(17)7-10-4-5-11(18-2)12(6-10)19-3/h4-6,8H,7H2,1-3H3,(H,15,16,17) OZTBSEAZYQWENG-UHFFFAOYSA-N 42681 2-(3,4-dimethoxyphenyl)-N-(4-methyl-1,3-thiazol-2-yl)acetamide::2-(3,4-dimethoxyphenyl)-N-(4-methyl-1,3-thiazol-2-yl)ethanamide::2-(3,4-dimethoxyphenyl)-N-(4-methyl-2-thiazolyl)acetamide::2-(3,4-dimethoxyphenyl)-N-(4-methylthiazol-2-yl)acetamide::MLS000098817::SMR000067416::cid_2107456 Mitogen-activated protein kinase 10 Homo sapiens 27950 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42681&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2107456 252623373 ZINC02644518 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79659 COc1ccc(cc1OC)-c1nnc(o1)-c1ccc(Br)o1 InChI=1S/C14H11BrN2O4/c1-18-9-4-3-8(7-11(9)19-2)13-16-17-14(21-13)10-5-6-12(15)20-10/h3-7H,1-2H3 CAJCHFLRAUBNQL-UHFFFAOYSA-N 39607 2-(5-bromanylfuran-2-yl)-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole::2-(5-bromo-2-furanyl)-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole::2-(5-bromo-2-furyl)-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole::2-(5-bromofuran-2-yl)-5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole::MLS000056595::SMR000064578::cid_1219876 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39607&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1219876 252620496 ZINC00994777 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79660 Cc1cc(C)n(n1)-c1ccc(cc1)C(=O)Nc1sccc1C(N)=O InChI=1S/C17H16N4O2S/c1-10-9-11(2)21(20-10)13-5-3-12(4-6-13)16(23)19-17-14(15(18)22)7-8-24-17/h3-9H,1-2H3,(H2,18,22)(H,19,23) FMKKPJVHKGIQDZ-UHFFFAOYSA-N 42682 2-[[4-(3,5-dimethylpyrazol-1-yl)benzoyl]amino]thiophene-3-carboxamide::2-[[4-(3,5-dimethylpyrazol-1-yl)phenyl]carbonylamino]thiophene-3-carboxamide::2-[[[4-(3,5-dimethyl-1-pyrazolyl)phenyl]-oxomethyl]amino]-3-thiophenecarboxamide::MLS000053831::SMR000066998::cid_2118395 Mitogen-activated protein kinase 10 Homo sapiens 44260 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42682&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2118395 252623374 ZINC02654844 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79661 COc1ccc(cc1COC(=O)c1c(C)noc1C)C(C)=O InChI=1S/C16H17NO5/c1-9-15(11(3)22-17-9)16(19)21-8-13-7-12(10(2)18)5-6-14(13)20-4/h5-7H,8H2,1-4H3 MVKGNLZDWGXTOF-UHFFFAOYSA-N 42683 (5-acetyl-2-methoxyphenyl)methyl 3,5-dimethyl-1,2-oxazole-4-carboxylate::(5-ethanoyl-2-methoxy-phenyl)methyl 3,5-dimethyl-1,2-oxazole-4-carboxylate::3,5-dimethyl-4-isoxazolecarboxylic acid (5-acetyl-2-methoxyphenyl)methyl ester::3,5-dimethylisoxazole-4-carboxylic acid (5-acetyl-2-methoxy-benzyl) ester::MLS000053816::SMR000068140::cid_2535734 Mitogen-activated protein kinase 10 Homo sapiens 39780 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42683&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2535734 252623375 ZINC03416688 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79662 O=c1[nH]c2ccccc2c(=O)n1Cc1ccco1 InChI=1S/C13H10N2O3/c16-12-10-5-1-2-6-11(10)14-13(17)15(12)8-9-4-3-7-18-9/h1-7H,8H2,(H,14,17) NZDDWKJGYHDQBP-UHFFFAOYSA-N 42684 3-(2-furanylmethyl)-1H-quinazoline-2,4-dione::3-(2-furfuryl)-1H-quinazoline-2,4-quinone::3-(furan-2-ylmethyl)-1H-quinazoline-2,4-dione::MLS000056751::SMR000066353::cid_2366703 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42684&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2366703 252623376 ZINC15424680 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79663 O=C(NCc1ccccn1)c1n[nH]c2ccccc12 InChI=1S/C14H12N4O/c19-14(16-9-10-5-3-4-8-15-10)13-11-6-1-2-7-12(11)17-18-13/h1-8H,9H2,(H,16,19)(H,17,18) MCPGTFMPDWURDA-UHFFFAOYSA-N 42685 MLS000056212::N-(2-pyridinylmethyl)-1H-indazole-3-carboxamide::N-(2-pyridylmethyl)-1H-indazole-3-carboxamide::N-(pyridin-2-ylmethyl)-1H-indazole-3-carboxamide::SMR000068017::cid_2999812 Mitogen-activated protein kinase 10 Homo sapiens 27980 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42685&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2999812 252623377 ZINC22768440 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79664 O=C(Cn1cnc2ccccc2c1=O)Nc1ccc(cc1)-c1nnc2CCCCCn12 InChI=1S/C23H22N6O2/c30-21(14-28-15-24-19-7-4-3-6-18(19)23(28)31)25-17-11-9-16(10-12-17)22-27-26-20-8-2-1-5-13-29(20)22/h3-4,6-7,9-12,15H,1-2,5,8,13-14H2,(H,25,30) CKRZPIPTCGGBDJ-UHFFFAOYSA-N 42686 2-(4-ketoquinazolin-3-yl)-N-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazol[4,3-a]azepin-3-yl)phenyl]acetamide::2-(4-oxidanylidenequinazolin-3-yl)-N-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)phenyl]ethanamide::2-(4-oxo-3-quinazolinyl)-N-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)phenyl]acetamide::2-(4-oxoquinazolin-3-yl)-N-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)phenyl]acetamide::MLS000054674::SMR000064851::cid_2715733 Mitogen-activated protein kinase 10 Homo sapiens 29480 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42686&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2715733 252623378 ZINC03621600 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79665 COc1ccc(cc1COC(=O)c1cc(C)oc1C)C(C)=O InChI=1S/C17H18O5/c1-10-7-15(12(3)22-10)17(19)21-9-14-8-13(11(2)18)5-6-16(14)20-4/h5-8H,9H2,1-4H3 FYXYUPRHTJRYHR-UHFFFAOYSA-N 42687 (5-acetyl-2-methoxyphenyl)methyl 2,5-dimethylfuran-3-carboxylate::(5-ethanoyl-2-methoxy-phenyl)methyl 2,5-dimethylfuran-3-carboxylate::2,5-dimethyl-3-furancarboxylic acid (5-acetyl-2-methoxyphenyl)methyl ester::2,5-dimethylfuran-3-carboxylic acid (5-acetyl-2-methoxy-benzyl) ester::MLS000055143::SMR000066777::cid_2111237 Mitogen-activated protein kinase 10 Homo sapiens 61790 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42687&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2111237 252623379 ZINC02648120 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79666 Cc1sc2nc(SCC(=O)Nc3sccc3C(N)=O)n(CC=C)c(=O)c2c1C InChI=1S/C18H18N4O3S3/c1-4-6-22-17(25)13-9(2)10(3)28-16(13)21-18(22)27-8-12(23)20-15-11(14(19)24)5-7-26-15/h4-5,7H,1,6,8H2,2-3H3,(H2,19,24)(H,20,23) FUZIWPKANNHWFY-UHFFFAOYSA-N 42688 2-[2-(5,6-dimethyl-4-oxidanylidene-3-prop-2-enyl-thieno[2,3-d]pyrimidin-2-yl)sulfanylethanoylamino]thiophene-3-carboxamide::2-[[2-(5,6-dimethyl-4-oxo-3-prop-2-enylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetyl]amino]thiophene-3-carboxamide::2-[[2-[(3-allyl-4-keto-5,6-dimethyl-thieno[2,3-d]pyrimidin-2-yl)thio]acetyl]amino]thiophene-3-carboxamide::2-[[2-[(5,6-dimethyl-4-oxo-3-prop-2-enyl-2-thieno[2,3-d]pyrimidinyl)thio]-1-oxoethyl]amino]-3-thiophenecarboxamide::MLS000058244::SMR000065084::cid_2589475 Mitogen-activated protein kinase 10 Homo sapiens 7930 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42688&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2589475 252623380 ZINC03470462 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79667 CC(=O)c1c(C)[nH]c(C(=O)OCn2nnc3ccccc3c2=O)c1C InChI=1S/C17H16N4O4/c1-9-14(11(3)22)10(2)18-15(9)17(24)25-8-21-16(23)12-6-4-5-7-13(12)19-20-21/h4-7,18H,8H2,1-3H3 GHNZBABTEPVDBG-UHFFFAOYSA-N 42689 (4-oxidanylidene-1,2,3-benzotriazin-3-yl)methyl 4-ethanoyl-3,5-dimethyl-1H-pyrrole-2-carboxylate::(4-oxo-1,2,3-benzotriazin-3-yl)methyl 4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylate::4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (4-keto-1,2,3-benzotriazin-3-yl)methyl ester::4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (4-oxo-1,2,3-benzotriazin-3-yl)methyl ester::MLS000055083::SMR000066720::cid_2109889 Mitogen-activated protein kinase 10 Homo sapiens 34210 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42689&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2109889 252623381 ZINC02646842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79668 O=C(COC(=O)c1n[nH]c2ccccc12)Nc1ccc(cc1)S(=O)(=O)N1CCCC1 InChI=1S/C20H20N4O5S/c25-18(13-29-20(26)19-16-5-1-2-6-17(16)22-23-19)21-14-7-9-15(10-8-14)30(27,28)24-11-3-4-12-24/h1-2,5-10H,3-4,11-13H2,(H,21,25)(H,22,23) MFFBAVUXCAMGJT-UHFFFAOYSA-N 42690 1H-indazole-3-carboxylic acid [2-keto-2-(4-pyrrolidinosulfonylanilino)ethyl] ester::1H-indazole-3-carboxylic acid [2-oxo-2-[4-(1-pyrrolidinylsulfonyl)anilino]ethyl] ester::MLS000057172::SMR000062134::[2-oxidanylidene-2-[(4-pyrrolidin-1-ylsulfonylphenyl)amino]ethyl] 1H-indazole-3-carboxylate::[2-oxo-2-(4-pyrrolidin-1-ylsulfonylanilino)ethyl] 1H-indazole-3-carboxylate::cid_2377706 Mitogen-activated protein kinase 10 Homo sapiens 6771 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42690&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2377706 252623382 ZINC87711564 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79669 CC(C)n1nc(C(=O)OCC(=O)N(C)C2CCS(=O)(=O)C2)c2ccccc2c1=O InChI=1S/C19H23N3O6S/c1-12(2)22-18(24)15-7-5-4-6-14(15)17(20-22)19(25)28-10-16(23)21(3)13-8-9-29(26,27)11-13/h4-7,12-13H,8-11H2,1-3H3 CJRFBODMNQSNPX-UHFFFAOYSA-N 42691 3-isopropyl-4-keto-phthalazine-1-carboxylic acid [2-[(1,1-diketothiolan-3-yl)-methyl-amino]-2-keto-ethyl] ester::4-oxo-3-propan-2-yl-1-phthalazinecarboxylic acid [2-[(1,1-dioxo-3-thiolanyl)-methylamino]-2-oxoethyl] ester::MLS000058637::SMR000068284::[2-[(1,1-dioxothiolan-3-yl)-methylamino]-2-oxoethyl] 4-oxo-3-propan-2-ylphthalazine-1-carboxylate::[2-[[1,1-bis(oxidanylidene)thiolan-3-yl]-methyl-amino]-2-oxidanylidene-ethyl] 4-oxidanylidene-3-propan-2-yl-phthalazine-1-carboxylate::cid_3000117 Mitogen-activated protein kinase 10 Homo sapiens 35450 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42691&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3000117 252623383 ZINC04144150 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79670 COC(=O)c1sc(Nc2ccccc2)nc1C InChI=1S/C12H12N2O2S/c1-8-10(11(15)16-2)17-12(13-8)14-9-6-4-3-5-7-9/h3-7H,1-2H3,(H,13,14) MIWAZZSIWVVADG-UHFFFAOYSA-N 42692 2-anilino-4-methyl-5-thiazolecarboxylic acid methyl ester::2-anilino-4-methyl-thiazole-5-carboxylic acid methyl ester::MLS000089874::SMR000024492::cid_972118::methyl (2E)-4-methyl-2-(phenylimino)-2,3-dihydro-1,3-thiazole-5-carboxylate::methyl 2-anilino-4-methyl-1,3-thiazole-5-carboxylate::methyl 4-methyl-2-phenylazanyl-1,3-thiazole-5-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42692&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 972118 252623384 ZINC01004541 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79671 CCOc1ccc(cc1)C(=O)Nc1c(oc2ccccc12)C(N)=O InChI=1S/C18H16N2O4/c1-2-23-12-9-7-11(8-10-12)18(22)20-15-13-5-3-4-6-14(13)24-16(15)17(19)21/h3-10H,2H2,1H3,(H2,19,21)(H,20,22) ZWTIQWQXDZHYMN-UHFFFAOYSA-N 37030 3-[(4-ethoxybenzoyl)amino]-1-benzofuran-2-carboxamide::3-[(4-ethoxybenzoyl)amino]coumarilamide::3-[(4-ethoxyphenyl)carbonylamino]-1-benzofuran-2-carboxamide::3-[[(4-ethoxyphenyl)-oxomethyl]amino]-2-benzofurancarboxamide::MLS000087905::SMR000015753::cid_3235679 Mitogen-activated protein kinase 10 Homo sapiens 34860 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37030&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3235679 252618002 ZINC03893431 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79672 COc1cccc(NC(=O)CCCn2c(=O)[nH]c3ccccc3c2=O)c1 InChI=1S/C19H19N3O4/c1-26-14-7-4-6-13(12-14)20-17(23)10-5-11-22-18(24)15-8-2-3-9-16(15)21-19(22)25/h2-4,6-9,12H,5,10-11H2,1H3,(H,20,23)(H,21,25) GTHMKPJXNPBUQD-UHFFFAOYSA-N 42693 4-(2,4-diketo-1H-quinazolin-3-yl)-N-(3-methoxyphenyl)butyramide::4-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(3-methoxyphenyl)butanamide::4-(2,4-dioxo-1H-quinazolin-3-yl)-N-(3-methoxyphenyl)butanamide::4-[2,4-bis(oxidanylidene)-1H-quinazolin-3-yl]-N-(3-methoxyphenyl)butanamide::MLS000094675::SMR000030228::cid_3235711 Mitogen-activated protein kinase 10 Homo sapiens 48080 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42693&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3235711 252623385 ZINC02952530 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79673 O=C(CCCCCn1c(=S)[nH]c2ccccc2c1=O)N1CCC2(CC1)OCCO2 InChI=1S/C21H27N3O4S/c25-18(23-12-9-21(10-13-23)27-14-15-28-21)8-2-1-5-11-24-19(26)16-6-3-4-7-17(16)22-20(24)29/h3-4,6-7H,1-2,5,8-15H2,(H,22,29) AQBWUEJVFPHJKP-UHFFFAOYSA-N 42694 3-[6-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-oxohexyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-one::3-[6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-keto-hexyl]-2-thioxo-1H-quinazolin-4-one::3-[6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-oxidanylidene-hexyl]-2-sulfanylidene-1H-quinazolin-4-one::3-[6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-6-oxohexyl]-2-sulfanylidene-1H-quinazolin-4-one::MLS000095221::SMR000030775::cid_3236088 Mitogen-activated protein kinase 10 Homo sapiens 29660 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42694&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3236088 252623386 ZINC02970455 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79674 Cc1[nH]c(=O)[nH]c1C(=O)CCCCC(=O)OCC(=O)Nc1ccccn1 InChI=1S/C17H20N4O5/c1-11-16(21-17(25)19-11)12(22)6-2-3-8-15(24)26-10-14(23)20-13-7-4-5-9-18-13/h4-5,7,9H,2-3,6,8,10H2,1H3,(H,18,20,23)(H2,19,21,25) LONPWPAKCRSCLJ-UHFFFAOYSA-N 42695 2-oxo-2-(pyridin-2-ylamino)ethyl 6-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoate::6-(5-methyl-2-oxo-1,3-dihydroimidazol-4-yl)-6-oxohexanoic acid [2-oxo-2-(2-pyridinylamino)ethyl] ester::6-keto-6-(2-keto-5-methyl-4-imidazolin-4-yl)hexanoic acid [2-keto-2-(2-pyridylamino)ethyl] ester::MLS000089842::SMR000024460::[2-oxidanylidene-2-(pyridin-2-ylamino)ethyl] 6-(5-methyl-2-oxidanylidene-1,3-dihydroimidazol-4-yl)-6-oxidanylidene-hexanoate::[2-oxo-2-(pyridin-2-ylamino)ethyl] 6-(5-methyl-2-oxo-1,3-dihydroimidazol-4-yl)-6-oxohexanoate::cid_3236256 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42695&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3236256 252623387 ZINC06498261 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79675 CC(=O)c1ccc(NC(=O)C2CC(=NO2)c2ccc(F)cc2)cc1 InChI=1S/C18H15FN2O3/c1-11(22)12-4-8-15(9-5-12)20-18(23)17-10-16(21-24-17)13-2-6-14(19)7-3-13/h2-9,17H,10H2,1H3,(H,20,23) LEGVOMLQZWNAFK-UHFFFAOYSA-N 39232 MLS000092690::N-(4-acetylphenyl)-3-(4-fluorophenyl)-2-isoxazoline-5-carboxamide::N-(4-acetylphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::N-(4-acetylphenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide::N-(4-ethanoylphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::SMR000028381::cid_3236317 Mitogen-activated protein kinase 10 Homo sapiens 6931 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39232&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3236317 252620128 ZINC04119279 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79676 c1ccc(cc1)-c1n[nH]c2ccccc12 InChI=1S/C13H10N2/c1-2-6-10(7-3-1)13-11-8-4-5-9-12(11)14-15-13/h1-9H,(H,14,15) MXBKCOLSUUYOHT-UHFFFAOYSA-N 42696 3-phenyl-1H-indazole::MLS000095818::SMR000031366::cid_300385 Mitogen-activated protein kinase 10 Homo sapiens 2341 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42696&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 300385 252623388 ZINC06498249 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79677 COc1cc(CN=C(C)C(C#N)C(N)=O)cc(OC)c1OC InChI=1S/C15H19N3O4/c1-9(11(7-16)15(17)19)18-8-10-5-12(20-2)14(22-4)13(6-10)21-3/h5-6,11H,8H2,1-4H3,(H2,17,19) YOMYVXXDPAAKHX-UHFFFAOYSA-N 42697 (2E)-2-cyano-3-[(3,4,5-trimethoxybenzyl)amino]but-2-enamide::(E)-2-cyano-3-[(3,4,5-trimethoxybenzyl)amino]but-2-enamide::(E)-2-cyano-3-[(3,4,5-trimethoxyphenyl)methylamino]-2-butenamide::(E)-2-cyano-3-[(3,4,5-trimethoxyphenyl)methylamino]but-2-enamide::MLS000089978::SMR000024596::cid_3236465 Mitogen-activated protein kinase 10 Homo sapiens 7159 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42697&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896544 252623389 51689 ZINC17751069 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79678 O=C(NCc1cccnc1)c1cccc2CN(C3CCCCC3)C(=O)c12 InChI=1S/C21H23N3O2/c25-20(23-13-15-6-5-11-22-12-15)18-10-4-7-16-14-24(21(26)19(16)18)17-8-2-1-3-9-17/h4-7,10-12,17H,1-3,8-9,13-14H2,(H,23,25) NTBXAEAPCVHXTB-UHFFFAOYSA-N 42698 2-cyclohexyl-3-keto-N-(3-pyridylmethyl)isoindoline-4-carboxamide::2-cyclohexyl-3-oxidanylidene-N-(pyridin-3-ylmethyl)-1H-isoindole-4-carboxamide::2-cyclohexyl-3-oxo-N-(3-pyridinylmethyl)-1H-isoindole-4-carboxamide::2-cyclohexyl-3-oxo-N-(pyridin-3-ylmethyl)-1H-isoindole-4-carboxamide::2-cyclohexyl-3-oxo-N-(pyridin-3-ylmethyl)isoindoline-4-carboxamide::MLS000045296::SMR000026888::cid_3236714 Mitogen-activated protein kinase 10 Homo sapiens 27370 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42698&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3236714 252623390 ZINC04057571 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79679 CCCN1Cc2cccc(C(=O)NCc3ccccc3)c2C1=O InChI=1S/C19H20N2O2/c1-2-11-21-13-15-9-6-10-16(17(15)19(21)23)18(22)20-12-14-7-4-3-5-8-14/h3-10H,2,11-13H2,1H3,(H,20,22) RHCLFQHNUZYWGL-UHFFFAOYSA-N 42699 3-oxidanylidene-N-(phenylmethyl)-2-propyl-1H-isoindole-4-carboxamide::3-oxo-N-(phenylmethyl)-2-propyl-1H-isoindole-4-carboxamide::MLS000045774::N-benzyl-3-keto-2-propyl-isoindoline-4-carboxamide::N-benzyl-3-oxo-2-propyl-1H-isoindole-4-carboxamide::N-benzyl-3-oxo-2-propylisoindoline-4-carboxamide::SMR000028171::cid_3236904 Mitogen-activated protein kinase 10 Homo sapiens 57830 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42699&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3236904 252623391 ZINC04111997 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79680 Cc1ccc(NC(=O)C2CC(=NO2)c2ccc(F)cc2)cc1 InChI=1S/C17H15FN2O2/c1-11-2-8-14(9-3-11)19-17(21)16-10-15(20-22-16)12-4-6-13(18)7-5-12/h2-9,16H,10H2,1H3,(H,19,21) UJAGMSMITAZBSP-UHFFFAOYSA-N 42700 3-(4-fluorophenyl)-N-(4-methylphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::3-(4-fluorophenyl)-N-(4-methylphenyl)-4,5-dihydroisoxazole-5-carboxamide::3-(4-fluorophenyl)-N-(p-tolyl)-2-isoxazoline-5-carboxamide::MLS000092691::SMR000028382::cid_3236938 Mitogen-activated protein kinase 10 Homo sapiens 32030 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42700&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3236938 252623392 ZINC04111910 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79681 O=C1C2C(NC(=O)N=C2c2ccccc12)c1ccccc1 InChI=1S/C17H12N2O2/c20-16-12-9-5-4-8-11(12)15-13(16)14(18-17(21)19-15)10-6-2-1-3-7-10/h1-9,13-14H,(H,18,21) HMIKVFWMLSWMFQ-UHFFFAOYSA-N 42701 4-phenyl-3,4-dihydro-1H-indeno[1,2-d]pyrimidine-2,5-dione::4-phenyl-3,4-dihydro-1H-indeno[1,2-d]pyrimidine-2,5-quinone::MLS000089719::SMR000024337::cid_3237127 Mitogen-activated protein kinase 10 Homo sapiens 38350 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42701&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896545 252623393 ZINC00103439 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79682 Sc1nnc(o1)-c1cccc(Br)c1 InChI=1S/C8H5BrN2OS/c9-6-3-1-2-5(4-6)7-10-11-8(13)12-7/h1-4H,(H,11,13) WZMCNMSXIKEYTO-UHFFFAOYSA-N 42702 5-(3-Bromo-phenyl)-3H-[1,3,4]oxadiazole-2-thione::5-(3-bromophenyl)-3H-1,3,4-oxadiazole-2-thione::MLS000085023::SMR000019369::cid_794839 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42702&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 794839 252623394 ZINC00497093 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79683 CCOc1ccc(CC(=O)Nc2c(oc3ccccc23)C(N)=O)cc1OCC InChI=1S/C21H22N2O5/c1-3-26-16-10-9-13(11-17(16)27-4-2)12-18(24)23-19-14-7-5-6-8-15(14)28-20(19)21(22)25/h5-11H,3-4,12H2,1-2H3,(H2,22,25)(H,23,24) ARRPMFYEKBZOMJ-UHFFFAOYSA-N 42703 3-[2-(3,4-diethoxyphenyl)ethanoylamino]-1-benzofuran-2-carboxamide::3-[[2-(3,4-diethoxyphenyl)-1-oxoethyl]amino]-2-benzofurancarboxamide::3-[[2-(3,4-diethoxyphenyl)acetyl]amino]-1-benzofuran-2-carboxamide::3-[[2-(3,4-diethoxyphenyl)acetyl]amino]coumarilamide::3-{[(3,4-diethoxyphenyl)acetyl]amino}-1-benzofuran-2-carboxamide::MLS000043953::SMR000021164::cid_1045996 Mitogen-activated protein kinase 10 Homo sapiens 4261 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42703&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1045996 252623395 ZINC00720308 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79684 CCCN1Cc2cccc(C(=O)NCc3ccc4OCOc4c3)c2C1=O InChI=1S/C20H20N2O4/c1-2-8-22-11-14-4-3-5-15(18(14)20(22)24)19(23)21-10-13-6-7-16-17(9-13)26-12-25-16/h3-7,9H,2,8,10-12H2,1H3,(H,21,23) MYAPBPMHUFNXOP-UHFFFAOYSA-N 42704 3-keto-N-piperonyl-2-propyl-isoindoline-4-carboxamide::MLS000045280::N-(1,3-benzodioxol-5-ylmethyl)-3-oxidanylidene-2-propyl-1H-isoindole-4-carboxamide::N-(1,3-benzodioxol-5-ylmethyl)-3-oxo-2-propyl-1H-isoindole-4-carboxamide::N-(1,3-benzodioxol-5-ylmethyl)-3-oxo-2-propylisoindoline-4-carboxamide::SMR000026872::cid_3237226 Mitogen-activated protein kinase 10 Homo sapiens 31840 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42704&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3237226 252623396 ZINC04111447 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79685 COC1(OC)N=C(N)C2(C#N)C(c3ccc4OCOc4c3)C12C#N InChI=1S/C16H14N4O4/c1-21-16(22-2)15(7-18)12(14(15,6-17)13(19)20-16)9-3-4-10-11(5-9)24-8-23-10/h3-5,12H,8H2,1-2H3,(H2,19,20) PNKPXOCANVHXSM-UHFFFAOYSA-N 39236 2-amino-6-(1,3-benzodioxol-5-yl)-4,4-dimethoxy-3-azabicyclo[3.1.0]hex-2-ene-1,5-dicarbonitrile::4-amino-6-(1,3-benzodioxol-5-yl)-2,2-dimethoxy-3-azabicyclo[3.1.0]hex-3-ene-1,5-dicarbonitrile::4-azanyl-6-(1,3-benzodioxol-5-yl)-2,2-dimethoxy-3-azabicyclo[3.1.0]hex-3-ene-1,5-dicarbonitrile::MLS000085495::SMR000020430::cid_3237447 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39236&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3237447 252620132 ZINC19874866 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79686 COc1ccc(cc1)C1C(CCC(=O)N1c1ccc(OC)cc1)C(=O)NCc1ccco1 InChI=1S/C25H26N2O5/c1-30-19-9-5-17(6-10-19)24-22(25(29)26-16-21-4-3-15-32-21)13-14-23(28)27(24)18-7-11-20(31-2)12-8-18/h3-12,15,22,24H,13-14,16H2,1-2H3,(H,26,29) JHUJLIIDWRHJFJ-UHFFFAOYSA-N 42705 MLS000086132::N-(2-furanylmethyl)-1,2-bis(4-methoxyphenyl)-6-oxo-3-piperidinecarboxamide::N-(2-furfuryl)-6-keto-1,2-bis(4-methoxyphenyl)nipecotamide::N-(2-furylmethyl)-1,2-bis(4-methoxyphenyl)-6-oxopiperidine-3-carboxamide::N-(furan-2-ylmethyl)-1,2-bis(4-methoxyphenyl)-6-oxidanylidene-piperidine-3-carboxamide::N-(furan-2-ylmethyl)-1,2-bis(4-methoxyphenyl)-6-oxopiperidine-3-carboxamide::SMR000021641::cid_3237657 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42705&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3237657 252623397 ZINC04110894 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79687 COc1cccc(c1)C1=NOC(C1)C(=O)NC1CCCCC1 InChI=1S/C17H22N2O3/c1-21-14-9-5-6-12(10-14)15-11-16(22-19-15)17(20)18-13-7-3-2-4-8-13/h5-6,9-10,13,16H,2-4,7-8,11H2,1H3,(H,18,20) GOKNYOHQPLPAOF-UHFFFAOYSA-N 42706 MLS000092675::N-cyclohexyl-3-(3-methoxyphenyl)-2-isoxazoline-5-carboxamide::N-cyclohexyl-3-(3-methoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::N-cyclohexyl-3-(3-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide::SMR000028366::cid_3237669 Mitogen-activated protein kinase 10 Homo sapiens 34570 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42706&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3237669 252623398 ZINC04110868 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79688 Cc1ccnc(NC(=O)CCCOc2cc(=O)n(C)c3ccccc23)c1 InChI=1S/C20H21N3O3/c1-14-9-10-21-18(12-14)22-19(24)8-5-11-26-17-13-20(25)23(2)16-7-4-3-6-15(16)17/h3-4,6-7,9-10,12-13H,5,8,11H2,1-2H3,(H,21,22,24) KRZBWKRPRKNWHY-UHFFFAOYSA-N 38959 4-(1-methyl-2-oxidanylidene-quinolin-4-yl)oxy-N-(4-methylpyridin-2-yl)butanamide::4-(1-methyl-2-oxoquinolin-4-yl)oxy-N-(4-methylpyridin-2-yl)butanamide::4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-(4-methylpyridin-2-yl)butanamide::4-[(1-methyl-2-oxo-4-quinolinyl)oxy]-N-(4-methyl-2-pyridinyl)butanamide::4-[(2-keto-1-methyl-4-quinolyl)oxy]-N-(4-methyl-2-pyridyl)butyramide::MLS000089581::SMR000027929::cid_3237904 Mitogen-activated protein kinase 10 Homo sapiens 62390 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38959&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3237904 252619859 ZINC04057390 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79689 CCn1ncc(C2=NOC(C2)C(=O)Nc2ccccc2C(=O)OC)c1C InChI=1S/C18H20N4O4/c1-4-22-11(2)13(10-19-22)15-9-16(26-21-15)17(23)20-14-8-6-5-7-12(14)18(24)25-3/h5-8,10,16H,4,9H2,1-3H3,(H,20,23) QXCMRVUGCPGZBQ-UHFFFAOYSA-N 42707 2-[[3-(1-ethyl-5-methyl-pyrazol-4-yl)-2-isoxazoline-5-carbonyl]amino]benzoic acid methyl ester::2-[[[3-(1-ethyl-5-methyl-4-pyrazolyl)-4,5-dihydroisoxazol-5-yl]-oxomethyl]amino]benzoic acid methyl ester::MLS000093168::SMR000028796::cid_3238045::methyl 2-({[3-(1-ethyl-5-methyl-1H-pyrazol-4-yl)-4,5-dihydroisoxazol-5-yl]carbonyl}amino)benzoate::methyl 2-[[3-(1-ethyl-5-methyl-pyrazol-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]carbonylamino]benzoate::methyl 2-[[3-(1-ethyl-5-methylpyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carbonyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 1819 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42707&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3238045 252623399 ZINC04104244 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79690 O=C(N1CCN(CC1)c1ccccc1)c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1 InChI=1S/C26H24N4O3/c31-24(29-16-14-28(15-17-29)21-6-2-1-3-7-21)20-12-10-19(11-13-20)18-30-25(32)22-8-4-5-9-23(22)27-26(30)33/h1-13H,14-18H2,(H,27,33) IGDCKRNSWXEZDI-UHFFFAOYSA-N 42708 3-[4-(4-phenylpiperazine-1-carbonyl)benzyl]-1H-quinazoline-2,4-quinone::3-[[4-(4-phenylpiperazin-1-yl)carbonylphenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-(4-phenylpiperazine-1-carbonyl)phenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-[oxo-(4-phenyl-1-piperazinyl)methyl]phenyl]methyl]-1H-quinazoline-2,4-dione::3-{4-[(4-phenylpiperazin-1-yl)carbonyl]benzyl}quinazoline-2,4(1H,3H)-dione::MLS000094649::SMR000030202::cid_3238372 Mitogen-activated protein kinase 10 Homo sapiens 7969 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42708&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3238372 252623400 ZINC04004842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79691 CCn1c(C)cs\c1=N/C(=O)c1ccccc1O InChI=1S/C13H14N2O2S/c1-3-15-9(2)8-18-13(15)14-12(17)10-6-4-5-7-11(10)16/h4-8,16H,3H2,1-2H3/b14-13- MIJZDGIXNWSXRQ-YPKPFQOOSA-N 42709 MLS000089878::N-(3-ethyl-4-methyl-1,3-thiazol-2-ylidene)-2-hydroxybenzamide::N-(3-ethyl-4-methyl-1,3-thiazol-2-ylidene)-2-oxidanyl-benzamide::N-(3-ethyl-4-methyl-2-thiazolylidene)-2-hydroxybenzamide::N-(3-ethyl-4-methyl-4-thiazolin-2-ylidene)-2-hydroxy-benzamide::N-[(2E)-3-ethyl-4-methyl-1,3-thiazol-2(3H)-ylidene]-2-hydroxybenzamide::SMR000024496::cid_3238416 Mitogen-activated protein kinase 10 Homo sapiens 40700 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42709&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3238416 252623401 ZINC13147519 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79692 COc1ccc(cc1OC)C(=O)NCc1cn2c(C)csc2n1 InChI=1S/C16H17N3O3S/c1-10-9-23-16-18-12(8-19(10)16)7-17-15(20)11-4-5-13(21-2)14(6-11)22-3/h4-6,8-9H,7H2,1-3H3,(H,17,20) ZWYLREGLTOFYTH-UHFFFAOYSA-N 38401 3,4-dimethoxy-N-[(3-methyl-6-imidazo[2,1-b]thiazolyl)methyl]benzamide::3,4-dimethoxy-N-[(3-methylimidazo[2,1-b][1,3]thiazol-6-yl)methyl]benzamide::3,4-dimethoxy-N-[(3-methylimidazo[2,1-b]thiazol-6-yl)methyl]benzamide::MLS000094191::SMR000016891::cid_3238659 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38401&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3238659 252619313 ZINC04004826 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79693 Clc1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1 InChI=1S/C26H23ClN4O3/c27-20-9-11-21(12-10-20)29-13-15-30(16-14-29)24(32)19-7-5-18(6-8-19)17-31-25(33)22-3-1-2-4-23(22)28-26(31)34/h1-12H,13-17H2,(H,28,34) BLXIVLAZCAJMMS-UHFFFAOYSA-N 42710 3-(4-{[4-(4-chlorophenyl)piperazin-1-yl]carbonyl}benzyl)quinazoline-2,4(1H,3H)-dione::3-[4-[4-(4-chlorophenyl)piperazine-1-carbonyl]benzyl]-1H-quinazoline-2,4-quinone::3-[[4-[4-(4-chlorophenyl)piperazin-1-yl]carbonylphenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-[4-(4-chlorophenyl)piperazine-1-carbonyl]phenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-[[4-(4-chlorophenyl)-1-piperazinyl]-oxomethyl]phenyl]methyl]-1H-quinazoline-2,4-dione::MLS000094652::SMR000030205::cid_3239062 Mitogen-activated protein kinase 10 Homo sapiens 87690 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42710&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3239062 252623402 ZINC02952265 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79694 Fc1ccccc1N1CCN(CCCNC(=O)CCCCCn2c(=O)[nH]c3ccccc3c2=O)CC1 InChI=1S/C27H34FN5O3/c28-22-10-4-6-12-24(22)32-19-17-31(18-20-32)15-8-14-29-25(34)13-2-1-7-16-33-26(35)21-9-3-5-11-23(21)30-27(33)36/h3-6,9-12H,1-2,7-8,13-20H2,(H,29,34)(H,30,36) JCSBYLJBGLEEPP-UHFFFAOYSA-N 42711 6-(2,4-diketo-1H-quinazolin-3-yl)-N-[3-[4-(2-fluorophenyl)piperazino]propyl]hexanamide::6-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-{3-[4-(2-fluorophenyl)piperazin-1-yl]propyl}hexanamide::6-(2,4-dioxo-1H-quinazolin-3-yl)-N-[3-[4-(2-fluorophenyl)-1-piperazinyl]propyl]hexanamide::6-(2,4-dioxo-1H-quinazolin-3-yl)-N-[3-[4-(2-fluorophenyl)piperazin-1-yl]propyl]hexanamide::6-[2,4-bis(oxidanylidene)-1H-quinazolin-3-yl]-N-[3-[4-(2-fluorophenyl)piperazin-1-yl]propyl]hexanamide::MLS000094630::SMR000030183::cid_3239150 Mitogen-activated protein kinase 10 Homo sapiens 35180 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42711&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3239150 252623403 ZINC04004732 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79695 CCOC(=O)c1cccc2C(N=O)c3ccccc3-c12 InChI=1S/C16H13NO3/c1-2-20-16(18)13-9-5-8-12-14(13)10-6-3-4-7-11(10)15(12)17-19/h3-9,15H,2H2,1H3 MJNHOAHIKLTUHL-UHFFFAOYSA-N 3993 9-hydroximinofluorene-4-carboxylic acid ethyl ester::cid_5400198 Mitogen-activated protein kinase 10 Homo sapiens 11480 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=3993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=3993&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91895604 252614767 ZINC95393419 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79696 COc1cccc(C2=NOC(C2)C(=O)Nc2cc(OC)c(OC)c(OC)c2)c1OC InChI=1S/C21H24N2O7/c1-25-15-8-6-7-13(19(15)28-4)14-11-18(30-23-14)21(24)22-12-9-16(26-2)20(29-5)17(10-12)27-3/h6-10,18H,11H2,1-5H3,(H,22,24) YGWFWAPUTWVGDK-UHFFFAOYSA-N 42712 3-(2,3-dimethoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-2-isoxazoline-5-carboxamide::3-(2,3-dimethoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::3-(2,3-dimethoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide::MLS000092700::SMR000028391::cid_3239708 Mitogen-activated protein kinase 10 Homo sapiens 4189 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42712&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3239708 252623404 ZINC04101189 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79697 COCc1cc(C)nc(SCC(=O)Nc2cc3OCOc3cc2C#N)c1C#N InChI=1S/C19H16N4O4S/c1-11-3-13(8-25-2)14(7-21)19(22-11)28-9-18(24)23-15-5-17-16(26-10-27-17)4-12(15)6-20/h3-5H,8-10H2,1-2H3,(H,23,24) MVMNUBKPALUZKS-UHFFFAOYSA-N 42713 MLS000043965::N-(6-cyano-1,3-benzodioxol-5-yl)-2-[3-cyano-4-(methoxymethyl)-6-methyl-pyridin-2-yl]sulfanyl-ethanamide::N-(6-cyano-1,3-benzodioxol-5-yl)-2-[3-cyano-4-(methoxymethyl)-6-methylpyridin-2-yl]sulfanylacetamide::N-(6-cyano-1,3-benzodioxol-5-yl)-2-[[3-cyano-4-(methoxymethyl)-6-methyl-2-pyridinyl]thio]acetamide::N-(6-cyano-1,3-benzodioxol-5-yl)-2-[[3-cyano-4-(methoxymethyl)-6-methyl-2-pyridyl]thio]acetamide::N-(6-cyano-1,3-benzodioxol-5-yl)-2-{[3-cyano-4-(methoxymethyl)-6-methylpyridin-2-yl]thio}acetamide::SMR000021376::cid_1267226 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42713&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1267226 252623405 ZINC01080168 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79698 Clc1cccc(NC(=O)CSc2nc(-c3ccco3)c(C#N)c(=O)[nH]2)c1 InChI=1S/C17H11ClN4O3S/c18-10-3-1-4-11(7-10)20-14(23)9-26-17-21-15(13-5-2-6-25-13)12(8-19)16(24)22-17/h1-7H,9H2,(H,20,23)(H,21,22,24) GZZLHIZFGQDPLE-UHFFFAOYSA-N 42714 MLS000089894::N-(3-chlorophenyl)-2-[[5-cyano-6-(2-furanyl)-4-oxo-1H-pyrimidin-2-yl]thio]acetamide::N-(3-chlorophenyl)-2-[[5-cyano-6-(2-furyl)-4-keto-1H-pyrimidin-2-yl]thio]acetamide::N-(3-chlorophenyl)-2-[[5-cyano-6-(furan-2-yl)-4-oxidanylidene-1H-pyrimidin-2-yl]sulfanyl]ethanamide::N-(3-chlorophenyl)-2-[[5-cyano-6-(furan-2-yl)-4-oxo-1H-pyrimidin-2-yl]sulfanyl]acetamide::N-(3-chlorophenyl)-2-{[5-cyano-4-(2-furyl)-6-oxo-1,6-dihydropyrimidin-2-yl]thio}acetamide::SMR000024512::cid_3240275 Mitogen-activated protein kinase 10 Homo sapiens 29660 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42714&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3240275 252623406 ZINC08578781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79699 Fc1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1 InChI=1S/C26H23FN4O3/c27-20-9-11-21(12-10-20)29-13-15-30(16-14-29)24(32)19-7-5-18(6-8-19)17-31-25(33)22-3-1-2-4-23(22)28-26(31)34/h1-12H,13-17H2,(H,28,34) WHXCHRBROARPJL-UHFFFAOYSA-N 42715 3-(4-{[4-(4-fluorophenyl)piperazin-1-yl]carbonyl}benzyl)quinazoline-2,4(1H,3H)-dione::3-[4-[4-(4-fluorophenyl)piperazine-1-carbonyl]benzyl]-1H-quinazoline-2,4-quinone::3-[[4-[4-(4-fluorophenyl)piperazin-1-yl]carbonylphenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-[4-(4-fluorophenyl)piperazine-1-carbonyl]phenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-[[4-(4-fluorophenyl)-1-piperazinyl]-oxomethyl]phenyl]methyl]-1H-quinazoline-2,4-dione::MLS000094650::SMR000030203::cid_3240330 Mitogen-activated protein kinase 10 Homo sapiens 8418 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42715&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3240330 252623407 ZINC02952251 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79700 CCn1cc(C2=NOC(C2)C(=O)Nc2ccccc2C(=O)OC)c(C)n1 InChI=1S/C18H20N4O4/c1-4-22-10-13(11(2)20-22)15-9-16(26-21-15)17(23)19-14-8-6-5-7-12(14)18(24)25-3/h5-8,10,16H,4,9H2,1-3H3,(H,19,23) MEAHRPUDLXWXHN-UHFFFAOYSA-N 42716 2-[[3-(1-ethyl-3-methyl-pyrazol-4-yl)-2-isoxazoline-5-carbonyl]amino]benzoic acid methyl ester::2-[[[3-(1-ethyl-3-methyl-4-pyrazolyl)-4,5-dihydroisoxazol-5-yl]-oxomethyl]amino]benzoic acid methyl ester::MLS000093180::SMR000028808::cid_3240660::methyl 2-({[3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydroisoxazol-5-yl]carbonyl}amino)benzoate::methyl 2-[[3-(1-ethyl-3-methyl-pyrazol-4-yl)-4,5-dihydro-1,2-oxazol-5-yl]carbonylamino]benzoate::methyl 2-[[3-(1-ethyl-3-methylpyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carbonyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 1892 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42716&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3240660 252623408 ZINC04099229 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79701 Cc1ccccc1-n1c(SCc2cc(=O)n3ccccc3n2)nc2n[nH]cc2c1=O InChI=1S/C21H16N6O2S/c1-13-6-2-3-7-16(13)27-20(29)15-11-22-25-19(15)24-21(27)30-12-14-10-18(28)26-9-5-4-8-17(26)23-14/h2-11H,12H2,1H3,(H,22,25) OGZCSHOYHQREAA-UHFFFAOYSA-N 42717 2-({[5-(2-methylphenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio}methyl)-4H-pyrido[1,2-a]pyrimidin-4-one::2-[[5-(2-methylphenyl)-4-oxidanylidene-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanylmethyl]pyrido[1,2-a]pyrimidin-4-one::2-[[5-(2-methylphenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanylmethyl]pyrido[1,2-a]pyrimidin-4-one::2-[[[4-keto-5-(o-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]methyl]pyrido[1,2-a]pyrimidin-4-one::2-[[[5-(2-methylphenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]methyl]-4-pyrido[1,2-a]pyrimidinone::MLS000046903::SMR000032914::cid_3240840 Mitogen-activated protein kinase 10 Homo sapiens 41750 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42717&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3240840 252623409 ZINC18178095 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79702 COc1cccc(c1)C1=NOC(C1)C(=O)Nc1ccc(cc1)C(C)=O InChI=1S/C19H18N2O4/c1-12(22)13-6-8-15(9-7-13)20-19(23)18-11-17(21-25-18)14-4-3-5-16(10-14)24-2/h3-10,18H,11H2,1-2H3,(H,20,23) CRFORAJNMDQJTB-UHFFFAOYSA-N 42718 MLS000092667::N-(4-acetylphenyl)-3-(3-methoxyphenyl)-2-isoxazoline-5-carboxamide::N-(4-acetylphenyl)-3-(3-methoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::N-(4-acetylphenyl)-3-(3-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide::N-(4-ethanoylphenyl)-3-(3-methoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::SMR000028358::cid_3240978 Mitogen-activated protein kinase 10 Homo sapiens 7984 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42718&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3240978 252623410 ZINC04436928 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79703 COc1ccc(cc1OC)C1=NOC(C1)C(=O)Nc1ccc(cc1)C(C)=O InChI=1S/C20H20N2O5/c1-12(23)13-4-7-15(8-5-13)21-20(24)19-11-16(22-27-19)14-6-9-17(25-2)18(10-14)26-3/h4-10,19H,11H2,1-3H3,(H,21,24) DVFVIGZLWGZZPI-UHFFFAOYSA-N 42719 3-(3,4-dimethoxyphenyl)-N-(4-ethanoylphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::MLS000092720::N-(4-acetylphenyl)-3-(3,4-dimethoxyphenyl)-2-isoxazoline-5-carboxamide::N-(4-acetylphenyl)-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::N-(4-acetylphenyl)-3-(3,4-dimethoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide::SMR000028411::cid_3241165 Mitogen-activated protein kinase 10 Homo sapiens 32200 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42719&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3241165 252623411 ZINC04436210 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79704 COc1cc(cc(OC)c1OC)C(=O)NCc1cn2ccccc2n1 InChI=1S/C18H19N3O4/c1-23-14-8-12(9-15(24-2)17(14)25-3)18(22)19-10-13-11-21-7-5-4-6-16(21)20-13/h4-9,11H,10H2,1-3H3,(H,19,22) KBEXGPXJYAOGCF-UHFFFAOYSA-N 42720 MLS000094354::N-(2-imidazo[1,2-a]pyridinylmethyl)-3,4,5-trimethoxybenzamide::N-(imidazo[1,2-a]pyridin-2-ylmethyl)-3,4,5-trimethoxy-benzamide::N-(imidazo[1,2-a]pyridin-2-ylmethyl)-3,4,5-trimethoxybenzamide::SMR000016898::cid_3241191 Mitogen-activated protein kinase 10 Homo sapiens 7873 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42720&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3241191 252623412 ZINC02960750 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79705 O=C1CCCc2nn(c(c12)-c1ccncc1)-c1ccccc1 InChI=1S/C18H15N3O/c22-16-8-4-7-15-17(16)18(13-9-11-19-12-10-13)21(20-15)14-5-2-1-3-6-14/h1-3,5-6,9-12H,4,7-8H2 RBAWWJIFEASVEK-UHFFFAOYSA-N 42721 2-phenyl-3-(4-pyridyl)-6,7-dihydro-5H-indazol-4-one::2-phenyl-3-pyridin-4-yl-2,5,6,7-tetrahydro-4H-indazol-4-one::2-phenyl-3-pyridin-4-yl-6,7-dihydro-5H-indazol-4-one::MLS000090274::SMR000024884::cid_3241417 Mitogen-activated protein kinase 10 Homo sapiens 42290 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42721&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3241417 252623413 ZINC00210846 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79706 COCCN1Cc2cccc(C(=O)NCc3ccc4OCOc4c3)c2C1=O InChI=1S/C20H20N2O5/c1-25-8-7-22-11-14-3-2-4-15(18(14)20(22)24)19(23)21-10-13-5-6-16-17(9-13)27-12-26-16/h2-6,9H,7-8,10-12H2,1H3,(H,21,23) YDRKWIZVWAPGRJ-UHFFFAOYSA-N 30872 3-keto-2-(2-methoxyethyl)-N-piperonyl-isoindoline-4-carboxamide::MLS000045288::N-(1,3-benzodioxol-5-ylmethyl)-2-(2-methoxyethyl)-3-oxidanylidene-1H-isoindole-4-carboxamide::N-(1,3-benzodioxol-5-ylmethyl)-2-(2-methoxyethyl)-3-oxo-1H-isoindole-4-carboxamide::N-(1,3-benzodioxol-5-ylmethyl)-2-(2-methoxyethyl)-3-oxoisoindoline-4-carboxamide::SMR000026880::cid_3241483 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30872&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3241483 252615127 ZINC04434942 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79707 COc1cccc(c1)C1=NOC(C1)C(=O)Nc1ccc(OC)c(OC)c1 InChI=1S/C19H20N2O5/c1-23-14-6-4-5-12(9-14)15-11-18(26-21-15)19(22)20-13-7-8-16(24-2)17(10-13)25-3/h4-10,18H,11H2,1-3H3,(H,20,22) RUSNEHISXMHECV-UHFFFAOYSA-N 42722 MLS000092668::N-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)-2-isoxazoline-5-carboxamide::N-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::N-(3,4-dimethoxyphenyl)-3-(3-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide::SMR000028359::cid_3241493 Mitogen-activated protein kinase 10 Homo sapiens 4604 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42722&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3241493 252623414 ZINC04434920 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79708 O=C(CCCn1c(=S)[nH]c2ccccc2c1=O)NC1CCCC1 InChI=1S/C17H21N3O2S/c21-15(18-12-6-1-2-7-12)10-5-11-20-16(22)13-8-3-4-9-14(13)19-17(20)23/h3-4,8-9,12H,1-2,5-7,10-11H2,(H,18,21)(H,19,23) VOYIYLAZUFYTGP-UHFFFAOYSA-N 37414 MLS000095297::N-cyclopentyl-4-(4-keto-2-thioxo-1H-quinazolin-3-yl)butyramide::N-cyclopentyl-4-(4-oxidanylidene-2-sulfanylidene-1H-quinazolin-3-yl)butanamide::N-cyclopentyl-4-(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)butanamide::N-cyclopentyl-4-(4-oxo-2-thioxo-1,4-dihydroquinazolin-3(2H)-yl)butanamide::SMR000030851::cid_3241597 Mitogen-activated protein kinase 10 Homo sapiens 64310 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37414&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3241597 252618385 ZINC00425052 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79709 Oc1ccccc1NC=C1C(=O)c2ccccc2C1=O InChI=1S/C16H11NO3/c18-14-8-4-3-7-13(14)17-9-12-15(19)10-5-1-2-6-11(10)16(12)20/h1-9,17-18H GRCNTRGUKRFBGH-UHFFFAOYSA-N 42723 2-[(2-hydroxyanilino)methylene]indane-1,3-quinone::2-[(2-hydroxyanilino)methylidene]indene-1,3-dione::2-[[(2-hydroxyphenyl)amino]methylidene]indene-1,3-dione::2-{[(2-hydroxyphenyl)amino]methylene}-1H-indene-1,3(2H)-dione::MLS000090106::SMR000024724::cid_3241704 Mitogen-activated protein kinase 10 Homo sapiens 23110 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42723&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3241704 252623415 ZINC13749986 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79710 CC(C)OC(=O)c1c(C)oc2ccc(OCC(N)=O)cc12 InChI=1S/C15H17NO5/c1-8(2)20-15(18)14-9(3)21-12-5-4-10(6-11(12)14)19-7-13(16)17/h4-6,8H,7H2,1-3H3,(H2,16,17) RISOMZYXVKYFBK-UHFFFAOYSA-N 42724 5-(2-amino-2-keto-ethoxy)-2-methyl-benzofuran-3-carboxylic acid isopropyl ester::5-(2-amino-2-oxoethoxy)-2-methyl-3-benzofurancarboxylic acid propan-2-yl ester::5-Carbamoylmethoxy-2-methyl-benzofuran-3-carboxylic acid isopropyl ester::MLS000085018::SMR000019364::cid_830058::propan-2-yl 5-(2-amino-2-oxoethoxy)-2-methyl-1-benzofuran-3-carboxylate::propan-2-yl 5-(2-azanyl-2-oxidanylidene-ethoxy)-2-methyl-1-benzofuran-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 44860 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42724&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 830058 252623416 ZINC00352368 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79711 COc1ccc(NC(=O)CCCCn2c(=O)[nH]c3ccccc3c2=O)cc1 InChI=1S/C20H21N3O4/c1-27-15-11-9-14(10-12-15)21-18(24)8-4-5-13-23-19(25)16-6-2-3-7-17(16)22-20(23)26/h2-3,6-7,9-12H,4-5,8,13H2,1H3,(H,21,24)(H,22,26) WIKDROXNEUOCEQ-UHFFFAOYSA-N 42725 5-(2,4-diketo-1H-quinazolin-3-yl)-N-(4-methoxyphenyl)valeramide::5-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(4-methoxyphenyl)pentanamide::5-(2,4-dioxo-1H-quinazolin-3-yl)-N-(4-methoxyphenyl)pentanamide::5-[2,4-bis(oxidanylidene)-1H-quinazolin-3-yl]-N-(4-methoxyphenyl)pentanamide::MLS000094664::SMR000030217::cid_3241818 Mitogen-activated protein kinase 10 Homo sapiens 55090 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42725&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3241818 252623417 ZINC02952420 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79712 CCOc1ccc(cc1)C1CC(=O)NC2=C1C(=O)CCC2 InChI=1S/C17H19NO3/c1-2-21-12-8-6-11(7-9-12)13-10-16(20)18-14-4-3-5-15(19)17(13)14/h6-9,13H,2-5,10H2,1H3,(H,18,20) WTMJZOIYKMQECG-UHFFFAOYSA-N 42726 4-(4-ethoxyphenyl)-1,3,4,6,7,8-hexahydroquinoline-2,5-dione::4-(4-ethoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1H,3H)-dione::4-p-phenetyl-1,3,4,6,7,8-hexahydroquinoline-2,5-quinone::MLS000090924::SMR000025527::cid_3162357 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42726&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3162357 252623418 ZINC04143843 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79713 COc1cccc(C2=NOC(C2)C(=O)Nc2cccc(c2)C(C)=O)c1OC InChI=1S/C20H20N2O5/c1-12(23)13-6-4-7-14(10-13)21-20(24)18-11-16(22-27-18)15-8-5-9-17(25-2)19(15)26-3/h4-10,18H,11H2,1-3H3,(H,21,24) JBCICVHERDHBKX-UHFFFAOYSA-N 42727 3-(2,3-dimethoxyphenyl)-N-(3-ethanoylphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::MLS000092699::N-(3-acetylphenyl)-3-(2,3-dimethoxyphenyl)-2-isoxazoline-5-carboxamide::N-(3-acetylphenyl)-3-(2,3-dimethoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::N-(3-acetylphenyl)-3-(2,3-dimethoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide::SMR000028390::cid_3241857 Mitogen-activated protein kinase 10 Homo sapiens 24490 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42727&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3241857 252623419 ZINC04078866 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79714 O=C1Nc2ccccc2C1C=Nc1nccs1 InChI=1S/C12H9N3OS/c16-11-9(7-14-12-13-5-6-17-12)8-3-1-2-4-10(8)15-11/h1-7,9H,(H,15,16) NZTZYPRTJQUCKG-UHFFFAOYSA-N 42728 (3Z)-3-[(1,3-thiazol-2-ylamino)methylene]-1,3-dihydro-2H-indol-2-one::(3Z)-3-[(1,3-thiazol-2-ylamino)methylidene]-1H-indol-2-one::(3Z)-3-[(2-thiazolylamino)methylidene]-1H-indol-2-one::(3Z)-3-[(thiazol-2-ylamino)methylene]oxindole::MLS000091090::SMR000025652::cid_5771415 Mitogen-activated protein kinase 10 Homo sapiens 46570 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42728&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896546 252623420 ZINC13750280 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79715 O=C(C1CCC(Cn2c(=S)[nH]c3ccccc3c2=O)CC1)N1CCOCC1 InChI=1S/C20H25N3O3S/c24-18(22-9-11-26-12-10-22)15-7-5-14(6-8-15)13-23-19(25)16-3-1-2-4-17(16)21-20(23)27/h1-4,14-15H,5-13H2,(H,21,27) ZLQTWTBHAYMOCS-UHFFFAOYSA-N 42729 3-[(4-morpholin-4-ylcarbonylcyclohexyl)methyl]-2-sulfanylidene-1H-quinazolin-4-one::3-[[4-(morpholine-4-carbonyl)cyclohexyl]methyl]-2-sulfanylidene-1H-quinazolin-4-one::3-[[4-(morpholine-4-carbonyl)cyclohexyl]methyl]-2-thioxo-1H-quinazolin-4-one::3-[[4-[4-morpholinyl(oxo)methyl]cyclohexyl]methyl]-2-sulfanylidene-1H-quinazolin-4-one::3-{[4-(morpholin-4-ylcarbonyl)cyclohexyl]methyl}-2-thioxo-2,3-dihydroquinazolin-4(1H)-one::MLS000095246::SMR000030800::cid_3242041 Mitogen-activated protein kinase 10 Homo sapiens 16560 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42729&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3242041 252623421 ZINC02971039 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79716 COc1ccc(NC(=O)C2CC(=NO2)c2ccc(OC)c(OC)c2)cc1OC InChI=1S/C20H22N2O6/c1-24-15-7-5-12(9-17(15)26-3)14-11-19(28-22-14)20(23)21-13-6-8-16(25-2)18(10-13)27-4/h5-10,19H,11H2,1-4H3,(H,21,23) YZDJXSFRXSZRSK-UHFFFAOYSA-N 42730 MLS000092721::N,3-bis(3,4-dimethoxyphenyl)-2-isoxazoline-5-carboxamide::N,3-bis(3,4-dimethoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::N,3-bis(3,4-dimethoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide::SMR000028412::cid_3242045 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42730&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3242045 252623422 ZINC04078337 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79717 On1c2c3ccccc3c(N=O)c2nc2ccccc12 InChI=1S/C15H9N3O2/c19-17-13-9-5-1-2-6-10(9)15-14(13)16-11-7-3-4-8-12(11)18(15)20/h1-8,20H OCERACDICRUDGM-UHFFFAOYSA-N 42731 (11Z)-11H-indeno[1,2-b]quinoxalin-11-one oxime 5-oxide::11-nitroso-5-oxidanyl-indeno[1,2-b]quinoxaline::5-hydroxy-11-nitroso-indeno[1,2-b]quinoxaline::5-hydroxy-11-nitrosoindeno[1,2-b]quinoxaline::MLS000043066::SMR000019493::cid_3242057 Mitogen-activated protein kinase 10 Homo sapiens 3356 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42731&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3242057 252623423 ZINC04078311 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79718 CC(C(O)=O)n1nc(C)c2sc3ccccc3c2c1=O InChI=1S/C14H12N2O3S/c1-7-12-11(9-5-3-4-6-10(9)20-12)13(17)16(15-7)8(2)14(18)19/h3-6,8H,1-2H3,(H,18,19) OSERJAMIDNURES-UHFFFAOYSA-N 42732 2-(1-keto-4-methyl-benzothiopheno[2,3-d]pyridazin-2-yl)propionic acid::2-(4-methyl-1-oxidanylidene-[1]benzothiolo[2,3-d]pyridazin-2-yl)propanoic acid::2-(4-methyl-1-oxo-[1]benzothiolo[2,3-d]pyridazin-2-yl)propanoic acid::2-(4-methyl-1-oxo[1]benzothieno[2,3-d]pyridazin-2(1H)-yl)propanoic acid::MLS000095840::SMR000031388::cid_3242118 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42732&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3242118 252623424 ZINC03913720 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79719 Cc1ccc(C)c(c1)N1CCN(CC1)C(=O)c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1 InChI=1S/C28H28N4O3/c1-19-7-8-20(2)25(17-19)30-13-15-31(16-14-30)26(33)22-11-9-21(10-12-22)18-32-27(34)23-5-3-4-6-24(23)29-28(32)35/h3-12,17H,13-16,18H2,1-2H3,(H,29,35) HGDUCBSDLHUBHJ-UHFFFAOYSA-N 42733 3-(4-{[4-(2,5-dimethylphenyl)piperazin-1-yl]carbonyl}benzyl)quinazoline-2,4(1H,3H)-dione::3-[4-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]benzyl]-1H-quinazoline-2,4-quinone::3-[[4-[4-(2,5-dimethylphenyl)piperazin-1-yl]carbonylphenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]phenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-[[4-(2,5-dimethylphenyl)-1-piperazinyl]-oxomethyl]phenyl]methyl]-1H-quinazoline-2,4-dione::MLS000094651::SMR000030204::cid_3242373 Mitogen-activated protein kinase 10 Homo sapiens 67510 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42733&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3242373 252623425 ZINC04004033 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79720 CN1C(C)=CC(C=C1C)=C1C(=O)c2ccccc2C1=O InChI=1S/C17H15NO2/c1-10-8-12(9-11(2)18(10)3)15-16(19)13-6-4-5-7-14(13)17(15)20/h4-9H,1-3H3 PCDJOTPRYJFJOS-UHFFFAOYSA-N 42734 2-(1,2,6-trimethyl-4-pyridinylidene)indene-1,3-dione::2-(1,2,6-trimethyl-4-pyridylidene)indane-1,3-quinone::2-(1,2,6-trimethylpyridin-4(1H)-ylidene)-1H-indene-1,3(2H)-dione::2-(1,2,6-trimethylpyridin-4-ylidene)indene-1,3-dione::MLS000090155::SMR000024772::cid_1535225 Mitogen-activated protein kinase 10 Homo sapiens 42090 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42734&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1535225 252623426 ZINC01463405 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79721 COC(=O)c1ccccc1NC(=O)C1CC(=NO1)c1ccc(F)cc1 InChI=1S/C18H15FN2O4/c1-24-18(23)13-4-2-3-5-14(13)20-17(22)16-10-15(21-25-16)11-6-8-12(19)9-7-11/h2-9,16H,10H2,1H3,(H,20,22) XISIMBLMRHMUEM-UHFFFAOYSA-N 42735 2-[[3-(4-fluorophenyl)-2-isoxazoline-5-carbonyl]amino]benzoic acid methyl ester::2-[[[3-(4-fluorophenyl)-4,5-dihydroisoxazol-5-yl]-oxomethyl]amino]benzoic acid methyl ester::MLS000092688::SMR000028379::cid_3242510::methyl 2-({[3-(4-fluorophenyl)-4,5-dihydroisoxazol-5-yl]carbonyl}amino)benzoate::methyl 2-[[3-(4-fluorophenyl)-4,5-dihydro-1,2-oxazol-5-yl]carbonylamino]benzoate::methyl 2-[[3-(4-fluorophenyl)-4,5-dihydro-1,2-oxazole-5-carbonyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 9211 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42735&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3242510 252623427 ZINC04077489 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79722 COC(=O)c1ccccc1NC(=O)CN1C(=O)C2CCCN2c2ncc(Cl)cc12 InChI=1S/C20H19ClN4O4/c1-29-20(28)13-5-2-3-6-14(13)23-17(26)11-25-16-9-12(21)10-22-18(16)24-8-4-7-15(24)19(25)27/h2-3,5-6,9-10,15H,4,7-8,11H2,1H3,(H,23,26) HQQWFUQUHBSMPQ-UHFFFAOYSA-N 35403 MLS000094302::SMR000029892::cid_3242856::methyl 2-{[(3-chloro-6-oxo-6a,7,8,9-tetrahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazin-5(6H)-yl)acetyl]amino}benzoate Mitogen-activated protein kinase 10 Homo sapiens 18230 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35403&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3242856 242052909 ZINC20465124 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79723 Fc1ccc2nc3[nH]c4ccccc4c3nc2c1 InChI=1S/C14H8FN3/c15-8-5-6-11-12(7-8)16-13-9-3-1-2-4-10(9)17-14(13)18-11/h1-7H,(H,17,18) XSBHLWCNFQDDTO-UHFFFAOYSA-N 42736 2-fluoranyl-6H-indolo[2,3-b]quinoxaline::2-fluoro-6H-indolo[2,3-b]quinoxaline::MLS000094577::SMR000030128::cid_5771437 Mitogen-activated protein kinase 10 Homo sapiens 18400 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42736&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5771437 252623428 ZINC06492967 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79724 COc1cc(cc(OC)c1OC)C(=O)NCc1cn2ccsc2n1 InChI=1S/C16H17N3O4S/c1-21-12-6-10(7-13(22-2)14(12)23-3)15(20)17-8-11-9-19-4-5-24-16(19)18-11/h4-7,9H,8H2,1-3H3,(H,17,20) PRRRXPOHSJADPQ-UHFFFAOYSA-N 42737 MLS000094187::N-(6-imidazo[2,1-b]thiazolylmethyl)-3,4,5-trimethoxybenzamide::N-(imidazo[2,1-b][1,3]thiazol-6-ylmethyl)-3,4,5-trimethoxy-benzamide::N-(imidazo[2,1-b][1,3]thiazol-6-ylmethyl)-3,4,5-trimethoxybenzamide::N-(imidazo[2,1-b]thiazol-6-ylmethyl)-3,4,5-trimethoxy-benzamide::SMR000016889::cid_3242965 Mitogen-activated protein kinase 10 Homo sapiens 53140 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42737&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3242965 252623429 ZINC04003943 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79725 COc1cccc(c1)C1=NOC(C1)C(=O)Nc1cc(OC)c(OC)c(OC)c1 InChI=1S/C20H22N2O6/c1-24-14-7-5-6-12(8-14)15-11-18(28-22-15)20(23)21-13-9-16(25-2)19(27-4)17(10-13)26-3/h5-10,18H,11H2,1-4H3,(H,21,23) NGCBEKFBQMYJMY-UHFFFAOYSA-N 42738 3-(3-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-2-isoxazoline-5-carboxamide::3-(3-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::3-(3-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide::MLS000092671::SMR000028362::cid_3242979 Mitogen-activated protein kinase 10 Homo sapiens 2023 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42738&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3242979 252623430 ZINC04076337 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79726 O=C1Nc2ccccc2C1C=Nc1ccc2OCCOc2c1 InChI=1S/C17H14N2O3/c20-17-13(12-3-1-2-4-14(12)19-17)10-18-11-5-6-15-16(9-11)22-8-7-21-15/h1-6,9-10,13H,7-8H2,(H,19,20) ZNKRGHDNVNYFQZ-UHFFFAOYSA-N 40969 (3Z)-3-[(2,3-dihydro-1,4-benzodioxin-6-ylamino)methylene]-1,3-dihydro-2H-indol-2-one::(3Z)-3-[(2,3-dihydro-1,4-benzodioxin-6-ylamino)methylene]oxindole::(3Z)-3-[(2,3-dihydro-1,4-benzodioxin-6-ylamino)methylidene]-1H-indol-2-one::MLS000091096::SMR000025658::cid_5771443 Mitogen-activated protein kinase 10 Homo sapiens 89940 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40969&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896494 252621748 ZINC13750283 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79727 CC1=CC(C=C(C)N1Cc1ccco1)=C1C(=O)c2ccccc2C1=O InChI=1S/C21H17NO3/c1-13-10-15(11-14(2)22(13)12-16-6-5-9-25-16)19-20(23)17-7-3-4-8-18(17)21(19)24/h3-11H,12H2,1-2H3 MHXSZWHQYPAFRO-UHFFFAOYSA-N 42739 2-[1-(2-furanylmethyl)-2,6-dimethyl-4-pyridinylidene]indene-1,3-dione::2-[1-(2-furfuryl)-2,6-dimethyl-4-pyridylidene]indane-1,3-quinone::2-[1-(2-furylmethyl)-2,6-dimethylpyridin-4(1H)-ylidene]-1H-indene-1,3(2H)-dione::2-[1-(furan-2-ylmethyl)-2,6-dimethyl-pyridin-4-ylidene]indene-1,3-dione::2-[1-(furan-2-ylmethyl)-2,6-dimethylpyridin-4-ylidene]indene-1,3-dione::MLS000090156::SMR000024773::cid_958894 Mitogen-activated protein kinase 10 Homo sapiens 22900 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42739&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 958894 252623431 ZINC00567599 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79728 CCOC(=O)C1CCN(CC1)C(=O)CCCCn1c(=O)[nH]c2ccccc2c1=O InChI=1S/C21H27N3O5/c1-2-29-20(27)15-10-13-23(14-11-15)18(25)9-5-6-12-24-19(26)16-7-3-4-8-17(16)22-21(24)28/h3-4,7-8,15H,2,5-6,9-14H2,1H3,(H,22,28) CZUYZFJTQCHWPI-UHFFFAOYSA-N 42740 1-[5-(2,4-diketo-1H-quinazolin-3-yl)pentanoyl]isonipecotic acid ethyl ester::1-[5-(2,4-dioxo-1H-quinazolin-3-yl)-1-oxopentyl]-4-piperidinecarboxylic acid ethyl ester::MLS000094678::SMR000030231::cid_3243208::ethyl 1-[5-(2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)pentanoyl]piperidine-4-carboxylate::ethyl 1-[5-(2,4-dioxo-1H-quinazolin-3-yl)pentanoyl]piperidine-4-carboxylate::ethyl 1-[5-[2,4-bis(oxidanylidene)-1H-quinazolin-3-yl]pentanoyl]piperidine-4-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 28650 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42740&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3243208 252623432 ZINC04003894 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79729 Clc1ccc2c(c1)[nH]c(=O)n(CCCC(=O)NCC1CCCO1)c2=O InChI=1S/C17H20ClN3O4/c18-11-5-6-13-14(9-11)20-17(24)21(16(13)23)7-1-4-15(22)19-10-12-3-2-8-25-12/h5-6,9,12H,1-4,7-8,10H2,(H,19,22)(H,20,24) JNSHWZVWSXNJOV-UHFFFAOYSA-N 42741 4-(7-chloro-2,4-diketo-1H-quinazolin-3-yl)-N-(tetrahydrofurfuryl)butyramide::4-(7-chloro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-N-(tetrahydrofuran-2-ylmethyl)butanamide::4-(7-chloro-2,4-dioxo-1H-quinazolin-3-yl)-N-(2-oxolanylmethyl)butanamide::4-(7-chloro-2,4-dioxo-1H-quinazolin-3-yl)-N-(oxolan-2-ylmethyl)butanamide::4-[7-chloranyl-2,4-bis(oxidanylidene)-1H-quinazolin-3-yl]-N-(oxolan-2-ylmethyl)butanamide::MLS000090682::SMR000025286::cid_3243213 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42741&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3243213 252623433 ZINC02467816 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79730 Fc1ccc(cc1)C1=NOC(C1)C(=O)Nc1ccc(cc1)C#N InChI=1S/C17H12FN3O2/c18-13-5-3-12(4-6-13)15-9-16(23-21-15)17(22)20-14-7-1-11(10-19)2-8-14/h1-8,16H,9H2,(H,20,22) TUYHAXDPQNIKOQ-UHFFFAOYSA-N 42742 MLS000092689::N-(4-cyanophenyl)-3-(4-fluorophenyl)-2-isoxazoline-5-carboxamide::N-(4-cyanophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::N-(4-cyanophenyl)-3-(4-fluorophenyl)-4,5-dihydroisoxazole-5-carboxamide::SMR000028380::cid_3243409 Mitogen-activated protein kinase 10 Homo sapiens 7928 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42742&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3243409 252623434 ZINC04035666 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79731 CCc1ccc(cc1)-n1c(SCC(=O)Nc2cc(C)n[nH]2)nc2n[nH]cc2c1=O InChI=1S/C19H19N7O2S/c1-3-12-4-6-13(7-5-12)26-18(28)14-9-20-25-17(14)22-19(26)29-10-16(27)21-15-8-11(2)23-24-15/h4-9H,3,10H2,1-2H3,(H,20,25)(H2,21,23,24,27) IBJKHYZJWUJLKC-UHFFFAOYSA-N 42743 2-[[5-(4-ethylphenyl)-4-keto-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-N-(5-methyl-1H-pyrazol-3-yl)acetamide::2-[[5-(4-ethylphenyl)-4-oxidanylidene-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]-N-(5-methyl-1H-pyrazol-3-yl)ethanamide::2-[[5-(4-ethylphenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl]-N-(5-methyl-1H-pyrazol-3-yl)acetamide::2-[[5-(4-ethylphenyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-N-(5-methyl-1H-pyrazol-3-yl)acetamide::2-{[5-(4-ethylphenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio}-N-(5-methyl-1H-pyrazol-3-yl)acetamide::MLS000046904::SMR000032915::cid_3243453 Mitogen-activated protein kinase 10 Homo sapiens 4058 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42743&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3243453 252623435 ZINC08578713 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79732 Cn1c(cc2c1c1ccccc1[nH]c2=O)C(=O)NCc1ccco1 InChI=1S/C18H15N3O3/c1-21-15(18(23)19-10-11-5-4-8-24-11)9-13-16(21)12-6-2-3-7-14(12)20-17(13)22/h2-9H,10H2,1H3,(H,19,23)(H,20,22) OQVSVPSMGQBUMJ-UHFFFAOYSA-N 42744 MLS000045446::N-(2-furanylmethyl)-1-methyl-4-oxo-5H-pyrrolo[3,2-c]quinoline-2-carboxamide::N-(2-furfuryl)-4-keto-1-methyl-5H-pyrrolo[3,2-c]quinoline-2-carboxamide::N-(2-furylmethyl)-1-methyl-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide::N-(furan-2-ylmethyl)-1-methyl-4-oxidanylidene-5H-pyrrolo[3,2-c]quinoline-2-carboxamide::N-(furan-2-ylmethyl)-1-methyl-4-oxo-5H-pyrrolo[3,2-c]quinoline-2-carboxamide::SMR000027206::cid_3243455 Mitogen-activated protein kinase 10 Homo sapiens 31440 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42744&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3243455 252623436 ZINC08606900 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79733 Cc1cc(NC(=O)CSC2=Nc3ccccc3C3=NC(Cc4ccccc4)C(=O)N23)[nH]n1 InChI=1S/C23H20N6O2S/c1-14-11-19(28-27-14)26-20(30)13-32-23-25-17-10-6-5-9-16(17)21-24-18(22(31)29(21)23)12-15-7-3-2-4-8-15/h2-11,18H,12-13H2,1H3,(H2,26,27,28,30) CEDSXKNLVNWYSN-UHFFFAOYSA-N 42745 2-[(2-benzyl-3-keto-2H-imidazo[1,2-c]quinazolin-5-yl)thio]-N-(5-methyl-1H-pyrazol-3-yl)acetamide::2-[(2-benzyl-3-oxo-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)thio]-N-(5-methyl-1H-pyrazol-3-yl)acetamide::2-[(2-benzyl-3-oxo-2H-imidazo[1,2-c]quinazolin-5-yl)sulfanyl]-N-(5-methyl-1H-pyrazol-3-yl)acetamide::MLS000094863::N-(5-methyl-1H-pyrazol-3-yl)-2-[[3-oxidanylidene-2-(phenylmethyl)-2H-imidazo[1,2-c]quinazolin-5-yl]sulfanyl]ethanamide::N-(5-methyl-1H-pyrazol-3-yl)-2-[[3-oxo-2-(phenylmethyl)-2H-imidazo[1,2-c]quinazolin-5-yl]thio]acetamide::SMR000030416::cid_3243616 Mitogen-activated protein kinase 10 Homo sapiens 11320 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42745&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3243616 252623437 ZINC04003820 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79734 Cc1nc2cccc(C(=O)NCc3ccccc3)c2o1 InChI=1S/C16H14N2O2/c1-11-18-14-9-5-8-13(15(14)20-11)16(19)17-10-12-6-3-2-4-7-12/h2-9H,10H2,1H3,(H,17,19) FYOHQZFLCBCAHZ-UHFFFAOYSA-N 40045 2-methyl-N-(phenylmethyl)-1,3-benzoxazole-7-carboxamide::MLS000086020::N-benzyl-2-methyl-1,3-benzoxazole-7-carboxamide::SMR000021349::cid_714012 Mitogen-activated protein kinase 10 Homo sapiens 45510 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40045&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 714012 252620875 ZINC00108490 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79735 O=C1Nc2cccnc2Sc2ccccc12 InChI=1S/C12H8N2OS/c15-11-8-4-1-2-6-10(8)16-12-9(14-11)5-3-7-13-12/h1-7H,(H,14,15) FTMBGAIUQQPJDQ-UHFFFAOYSA-N 42746 5H-pyrido[2,3-b][1,4]benzothiazepin-6-one::MLS000093580::SMR000029198::cid_3243778::pyrido[2,3-b][1,4]benzothiazepin-6(5H)-one Mitogen-activated protein kinase 10 Homo sapiens 5004 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42746&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3243778 252623438 ZINC04035373 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79736 CCOc1ncccc1C(=O)Nc1cccc(c1)C(=O)Nc1cccc(c1)S(=O)(=O)CCO InChI=1S/C23H23N3O6S/c1-2-32-23-20(10-5-11-24-23)22(29)26-17-7-3-6-16(14-17)21(28)25-18-8-4-9-19(15-18)33(30,31)13-12-27/h3-11,14-15,27H,2,12-13H2,1H3,(H,25,28)(H,26,29) KPGOUKKEQDUDBY-UHFFFAOYSA-N 42747 2-ethoxy-N-[3-[[3-(2-hydroxyethylsulfonyl)anilino]-oxomethyl]phenyl]-3-pyridinecarboxamide::2-ethoxy-N-[3-[[3-(2-hydroxyethylsulfonyl)phenyl]carbamoyl]phenyl]nicotinamide::2-ethoxy-N-[3-[[3-(2-hydroxyethylsulfonyl)phenyl]carbamoyl]phenyl]pyridine-3-carboxamide::2-ethoxy-N-{3-[({3-[(2-hydroxyethyl)sulfonyl]phenyl}amino)carbonyl]phenyl}nicotinamide::MLS000094592::SMR000030145::cid_3243903 Mitogen-activated protein kinase 10 Homo sapiens 5586 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42747&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3243903 252623439 ZINC03584642 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79737 CCOC(=O)CSc1nc2c3ccccc3sc2c(=O)n1CCCN1CCOCC1 InChI=1S/C21H25N3O4S2/c1-2-28-17(25)14-29-21-22-18-15-6-3-4-7-16(15)30-19(18)20(26)24(21)9-5-8-23-10-12-27-13-11-23/h3-4,6-7H,2,5,8-14H2,1H3 ZTZGHGIXEJYDBR-UHFFFAOYSA-N 42748 2-[[3-[3-(4-morpholinyl)propyl]-4-oxo-[1]benzothiolo[3,2-d]pyrimidin-2-yl]thio]acetic acid ethyl ester::2-[[4-keto-3-(3-morpholinopropyl)benzothiopheno[3,2-d]pyrimidin-2-yl]thio]acetic acid ethyl ester::MLS000094846::SMR000030399::cid_3243922::ethyl 2-[[3-(3-morpholin-4-ylpropyl)-4-oxidanylidene-[1]benzothiolo[3,2-d]pyrimidin-2-yl]sulfanyl]ethanoate::ethyl 2-[[3-(3-morpholin-4-ylpropyl)-4-oxo-[1]benzothiolo[3,2-d]pyrimidin-2-yl]sulfanyl]acetate::ethyl {[3-(3-morpholin-4-ylpropyl)-4-oxo-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-2-yl]thio}acetate Mitogen-activated protein kinase 10 Homo sapiens 40020 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42748&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3243922 252623440 ZINC20640985 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79738 Cc1ccnc(NC(=O)CSc2cc(=O)n(C)c3ccccc23)c1 InChI=1S/C18H17N3O2S/c1-12-7-8-19-16(9-12)20-17(22)11-24-15-10-18(23)21(2)14-6-4-3-5-13(14)15/h3-10H,11H2,1-2H3,(H,19,20,22) DYHJRLGCTHXTDZ-UHFFFAOYSA-N 42749 2-(1-methyl-2-oxidanylidene-quinolin-4-yl)sulfanyl-N-(4-methylpyridin-2-yl)ethanamide::2-(1-methyl-2-oxoquinolin-4-yl)sulfanyl-N-(4-methylpyridin-2-yl)acetamide::2-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)thio]-N-(4-methylpyridin-2-yl)acetamide::2-[(1-methyl-2-oxo-4-quinolinyl)thio]-N-(4-methyl-2-pyridinyl)acetamide::2-[(2-keto-1-methyl-4-quinolyl)thio]-N-(4-methyl-2-pyridyl)acetamide::MLS000092120::SMR000027024::cid_3244018 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42749&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3244018 252623441 ZINC04035208 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79739 COc1cccc(c1)C1=NOC(C1)C(=O)Nc1cccc(c1)C(C)=O InChI=1S/C19H18N2O4/c1-12(22)13-5-3-7-15(9-13)20-19(23)18-11-17(21-25-18)14-6-4-8-16(10-14)24-2/h3-10,18H,11H2,1-2H3,(H,20,23) OUDNUWGVIGSORZ-UHFFFAOYSA-N 42750 MLS000092669::N-(3-acetylphenyl)-3-(3-methoxyphenyl)-2-isoxazoline-5-carboxamide::N-(3-acetylphenyl)-3-(3-methoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::N-(3-acetylphenyl)-3-(3-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxamide::N-(3-ethanoylphenyl)-3-(3-methoxyphenyl)-4,5-dihydro-1,2-oxazole-5-carboxamide::SMR000028360::cid_3244490 Mitogen-activated protein kinase 10 Homo sapiens 12780 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42750&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3244490 252623442 ZINC04034884 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79740 O=C(CCCCCn1c(SCC(=O)c2ccccc2)nc2ccccc2c1=O)NCc1ccco1 InChI=1S/C27H27N3O4S/c31-24(20-10-3-1-4-11-20)19-35-27-29-23-14-7-6-13-22(23)26(33)30(27)16-8-2-5-15-25(32)28-18-21-12-9-17-34-21/h1,3-4,6-7,9-14,17H,2,5,8,15-16,18-19H2,(H,28,32) XQNKDDWGAYFBBO-UHFFFAOYSA-N 42751 MLS000095224::N-(2-furanylmethyl)-6-[4-oxo-2-(phenacylthio)-3-quinazolinyl]hexanamide::N-(2-furfuryl)-6-[4-keto-2-(phenacylthio)quinazolin-3-yl]hexanamide::N-(2-furylmethyl)-6-[4-oxo-2-[(2-oxo-2-phenylethyl)thio]quinazolin-3(4H)-yl]hexanamide::N-(furan-2-ylmethyl)-6-(4-oxidanylidene-2-phenacylsulfanyl-quinazolin-3-yl)hexanamide::N-(furan-2-ylmethyl)-6-(4-oxo-2-phenacylsulfanylquinazolin-3-yl)hexanamide::SMR000030778::cid_3244681 Mitogen-activated protein kinase 10 Homo sapiens 38910 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42751&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3244681 252623443 ZINC04034740 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79741 O=C(CCCCCn1c(SCc2ccncc2)nc2ccccc2c1=O)NCc1ccco1 InChI=1S/C25H26N4O3S/c30-23(27-17-20-7-6-16-32-20)10-2-1-5-15-29-24(31)21-8-3-4-9-22(21)28-25(29)33-18-19-11-13-26-14-12-19/h3-4,6-9,11-14,16H,1-2,5,10,15,17-18H2,(H,27,30) MKOABWNEWKDAIC-UHFFFAOYSA-N 42752 MLS000095223::N-(2-furanylmethyl)-6-[4-oxo-2-(pyridin-4-ylmethylthio)-3-quinazolinyl]hexanamide::N-(2-furfuryl)-6-[4-keto-2-(4-pyridylmethylthio)quinazolin-3-yl]hexanamide::N-(2-furylmethyl)-6-[4-oxo-2-[(pyridin-4-ylmethyl)thio]quinazolin-3(4H)-yl]hexanamide::N-(furan-2-ylmethyl)-6-[4-oxidanylidene-2-(pyridin-4-ylmethylsulfanyl)quinazolin-3-yl]hexanamide::N-(furan-2-ylmethyl)-6-[4-oxo-2-(pyridin-4-ylmethylsulfanyl)quinazolin-3-yl]hexanamide::SMR000030777::cid_3244812 Mitogen-activated protein kinase 10 Homo sapiens 73050 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42752&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3244812 252623444 ZINC02970461 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79742 O=C(Nc1nncs1)c1ccc(cc1)N1C(=O)C2C3CC(C=C3)C2C1=O InChI=1S/C18H14N4O3S/c23-15(20-18-21-19-8-26-18)9-3-5-12(6-4-9)22-16(24)13-10-1-2-11(7-10)14(13)17(22)25/h1-6,8,10-11,13-14H,7H2,(H,20,21,23) NGRGJBMARGRWOI-UHFFFAOYSA-N 42753 4-(1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl)-N-1,3,4-thiadiazol-2-ylbenzamide::MLS000085035::SMR000019381::cid_3244816 Mitogen-activated protein kinase 10 Homo sapiens 62890 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42753&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3244816 242053029 ZINC04034632 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79743 Nc1nc(cc(n1)-c1ccccc1O)-c1ccccc1 InChI=1S/C16H13N3O/c17-16-18-13(11-6-2-1-3-7-11)10-14(19-16)12-8-4-5-9-15(12)20/h1-10,20H,(H2,17,18,19) SXELSOZGQKZOPI-UHFFFAOYSA-N 42754 (6E)-6-(2-amino-4-phenyl-1H-pyrimidin-6-ylidene)-1-cyclohexa-2,4-dienone::(6E)-6-(2-amino-4-phenyl-1H-pyrimidin-6-ylidene)cyclohexa-2,4-dien-1-one::(6E)-6-(2-azanyl-4-phenyl-1H-pyrimidin-6-ylidene)cyclohexa-2,4-dien-1-one::2-(2-amino-6-phenylpyrimidin-4-yl)phenol::MLS000090090::SMR000024708::cid_5387168 Mitogen-activated protein kinase 10 Homo sapiens 40640 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42754&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5387168 252623445 ZINC13130002 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79744 COc1cccc(c1)C1=NOC(C1)C(=O)Nc1cccnc1 InChI=1S/C16H15N3O3/c1-21-13-6-2-4-11(8-13)14-9-15(22-19-14)16(20)18-12-5-3-7-17-10-12/h2-8,10,15H,9H2,1H3,(H,18,20) OAYLZJHVKRLXBQ-UHFFFAOYSA-N 42755 3-(3-methoxyphenyl)-N-(3-pyridinyl)-4,5-dihydroisoxazole-5-carboxamide::3-(3-methoxyphenyl)-N-(3-pyridyl)-2-isoxazoline-5-carboxamide::3-(3-methoxyphenyl)-N-pyridin-3-yl-4,5-dihydro-1,2-oxazole-5-carboxamide::3-(3-methoxyphenyl)-N-pyridin-3-yl-4,5-dihydroisoxazole-5-carboxamide::MLS000092670::SMR000028361::cid_3245136 Mitogen-activated protein kinase 10 Homo sapiens 12460 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42755&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3245136 252623446 ZINC04034412 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79745 CCOc1ccccc1NC(=O)CSc1nc(N)c(cc1C#N)C#N InChI=1S/C17H15N5O2S/c1-2-24-14-6-4-3-5-13(14)21-15(23)10-25-17-12(9-19)7-11(8-18)16(20)22-17/h3-7H,2,10H2,1H3,(H2,20,22)(H,21,23) MYWRFFKONORMFJ-UHFFFAOYSA-N 42756 2-(6-amino-3,5-dicyanopyridin-2-yl)sulfanyl-N-(2-ethoxyphenyl)acetamide::2-(6-azanyl-3,5-dicyano-pyridin-2-yl)sulfanyl-N-(2-ethoxyphenyl)ethanamide::2-[(6-amino-3,5-dicyano-2-pyridinyl)thio]-N-(2-ethoxyphenyl)acetamide::2-[(6-amino-3,5-dicyano-2-pyridyl)thio]-N-o-phenetyl-acetamide::2-[(6-amino-3,5-dicyanopyridin-2-yl)thio]-N-(2-ethoxyphenyl)acetamide::MLS000085759::SMR000020888::cid_2868371 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42756&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2868371 252623447 ZINC19830754 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79746 Cc1ccccc1Nc1nn2c(nc3ccccc3c2=O)s1 InChI=1S/C16H12N4OS/c1-10-6-2-4-8-12(10)17-15-19-20-14(21)11-7-3-5-9-13(11)18-16(20)22-15/h2-9H,1H3,(H,17,19) FVSMUFZKSNZOGY-UHFFFAOYSA-N 42757 2-(2-methylanilino)-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one::2-(o-toluidino)-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one::2-[(2-methylphenyl)amino]-5H-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one::2-[(2-methylphenyl)amino]-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one::MLS000095262::SMR000030816::cid_3245237 Mitogen-activated protein kinase 10 Homo sapiens 39330 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42757&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3245237 252623448 ZINC02971383 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79747 CCOC(=O)CSc1nc2ccccc2c(=O)n1CCCCCC(=O)NCc1ccco1 InChI=1S/C23H27N3O5S/c1-2-30-21(28)16-32-23-25-19-11-6-5-10-18(19)22(29)26(23)13-7-3-4-12-20(27)24-15-17-9-8-14-31-17/h5-6,8-11,14H,2-4,7,12-13,15-16H2,1H3,(H,24,27) LBWNQMXPCLRBGK-UHFFFAOYSA-N 42758 2-[[3-[6-(2-furanylmethylamino)-6-oxohexyl]-4-oxo-2-quinazolinyl]thio]acetic acid ethyl ester::2-[[3-[6-(2-furfurylamino)-6-keto-hexyl]-4-keto-quinazolin-2-yl]thio]acetic acid ethyl ester::MLS000095222::SMR000030776::cid_3245433::ethyl 2-[3-[6-(furan-2-ylmethylamino)-6-oxidanylidene-hexyl]-4-oxidanylidene-quinazolin-2-yl]sulfanylethanoate::ethyl 2-[3-[6-(furan-2-ylmethylamino)-6-oxohexyl]-4-oxoquinazolin-2-yl]sulfanylacetate::ethyl [(3-{6-[(2-furylmethyl)amino]-6-oxohexyl}-4-oxo-3,4-dihydroquinazolin-2-yl)thio]acetate Mitogen-activated protein kinase 10 Homo sapiens 43250 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42758&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3245433 252623449 ZINC03959232 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79748 Cc1cc(C(F)F)n2ncc(C(=O)NCc3ccccc3C(F)(F)F)c2n1 InChI=1S/C17H13F5N4O/c1-9-6-13(14(18)19)26-15(25-9)11(8-24-26)16(27)23-7-10-4-2-3-5-12(10)17(20,21)22/h2-6,8,14H,7H2,1H3,(H,23,27) NFEMHWGKIMYZJN-UHFFFAOYSA-N 42759 7-(difluoromethyl)-5-methyl-N-[2-(trifluoromethyl)benzyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide::7-(difluoromethyl)-5-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]-3-pyrazolo[1,5-a]pyrimidinecarboxamide::7-(difluoromethyl)-5-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide::7-[bis(fluoranyl)methyl]-5-methyl-N-[[2-(trifluoromethyl)phenyl]methyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide::MLS000090310::SMR000024920::cid_3245446 Mitogen-activated protein kinase 10 Homo sapiens 26190 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42759&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3245446 252623450 ZINC02784313 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79749 COc1ccc(cc1OC)N=CC1C(=O)Nc2ccccc12 InChI=1S/C17H16N2O3/c1-21-15-8-7-11(9-16(15)22-2)18-10-13-12-5-3-4-6-14(12)19-17(13)20/h3-10,13H,1-2H3,(H,19,20) CDQXCUQMYDDRNG-UHFFFAOYSA-N 40974 (3Z)-3-[(3,4-dimethoxyanilino)methylene]oxindole::(3Z)-3-[(3,4-dimethoxyanilino)methylidene]-1H-indol-2-one::(3Z)-3-[[(3,4-dimethoxyphenyl)amino]methylidene]-1H-indol-2-one::(3Z)-3-{[(3,4-dimethoxyphenyl)amino]methylene}-1,3-dihydro-2H-indol-2-one::MLS000043274::SMR000019894::cid_5771508 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40974&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896495 252621753 ZINC13750006 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79750 CCCc1cc(=O)n2c(n1)[nH]c1ccccc21 InChI=1S/C13H13N3O/c1-2-5-9-8-12(17)16-11-7-4-3-6-10(11)15-13(16)14-9/h3-4,6-8H,2,5H2,1H3,(H,14,15) WGMXAVYQOAAPEU-UHFFFAOYSA-N 42760 2-propyl-1H-pyrimido[1,2-a]benzimidazol-4-one::2-propylpyrimido[1,2-a]benzimidazol-4(1H)-one::MLS000066593::SMR000082459::cid_1402124 Mitogen-activated protein kinase 10 Homo sapiens 35030 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42760&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1402124 252623451 ZINC04036842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79751 Brc1ccc(o1)C(=O)NCC(=O)Nc1cccc(c1)-c1cnc2ccccc2n1 InChI=1S/C21H15BrN4O3/c22-19-9-8-18(29-19)21(28)24-12-20(27)25-14-5-3-4-13(10-14)17-11-23-15-6-1-2-7-16(15)26-17/h1-11H,12H2,(H,24,28)(H,25,27) SWCVULINRMVIHU-UHFFFAOYSA-N 42761 5-bromanyl-N-[2-oxidanylidene-2-[(3-quinoxalin-2-ylphenyl)amino]ethyl]furan-2-carboxamide::5-bromo-N-(2-oxo-2-{[3-(2-quinoxalinyl)phenyl]amino}ethyl)-2-furamide (non-preferred name)::5-bromo-N-[2-keto-2-(3-quinoxalin-2-ylanilino)ethyl]-2-furamide::5-bromo-N-[2-oxo-2-(3-quinoxalin-2-ylanilino)ethyl]furan-2-carboxamide::5-bromo-N-[2-oxo-2-[3-(2-quinoxalinyl)anilino]ethyl]-2-furancarboxamide::MLS000052435::SMR000081829::cid_2232040 Mitogen-activated protein kinase 10 Homo sapiens 41220 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42761&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2232040 252623452 ZINC02879928 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79752 COc1ccccc1NC(=O)COc1ccc(CO)cc1Cl InChI=1S/C16H16ClNO4/c1-21-15-5-3-2-4-13(15)18-16(20)10-22-14-7-6-11(9-19)8-12(14)17/h2-8,19H,9-10H2,1H3,(H,18,20) GAAREPHHNDVEFS-UHFFFAOYSA-N 42762 2-(2-chloro-4-methylol-phenoxy)-N-(2-methoxyphenyl)acetamide::2-[2-chloranyl-4-(hydroxymethyl)phenoxy]-N-(2-methoxyphenyl)ethanamide::2-[2-chloro-4-(hydroxymethyl)phenoxy]-N-(2-methoxyphenyl)acetamide::MLS000066246::SMR000079893::cid_1266427 Mitogen-activated protein kinase 10 Homo sapiens 68610 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42762&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1266427 252623453 ZINC01079295 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79753 Brc1ccc(o1)C(=O)Nc1ccccc1N1CCCC1 InChI=1S/C15H15BrN2O2/c16-14-8-7-13(20-14)15(19)17-11-5-1-2-6-12(11)18-9-3-4-10-18/h1-2,5-8H,3-4,9-10H2,(H,17,19) VQBHUVKMXXSCFA-UHFFFAOYSA-N 42763 5-bromanyl-N-(2-pyrrolidin-1-ylphenyl)furan-2-carboxamide::5-bromo-N-(2-pyrrolidin-1-ylphenyl)furan-2-carboxamide::5-bromo-N-(2-pyrrolidinophenyl)-2-furamide::5-bromo-N-[2-(1-pyrrolidinyl)phenyl]-2-furamide::5-bromo-N-[2-(1-pyrrolidinyl)phenyl]-2-furancarboxamide::MLS000088612::SMR000072607::cid_890518 Mitogen-activated protein kinase 10 Homo sapiens 64360 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42763&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 890518 252623454 ZINC00465585 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79754 O=C(CCCn1c(=S)[nH]c2ccccc2c1=O)NCc1ccco1 InChI=1S/C17H17N3O3S/c21-15(18-11-12-5-4-10-23-12)8-3-9-20-16(22)13-6-1-2-7-14(13)19-17(20)24/h1-2,4-7,10H,3,8-9,11H2,(H,18,21)(H,19,24) LOBLIRJGEHWKHR-UHFFFAOYSA-N 42764 MLS000049670::N-(2-furanylmethyl)-4-(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)butanamide::N-(2-furfuryl)-4-(4-keto-2-thioxo-1H-quinazolin-3-yl)butyramide::N-(2-furylmethyl)-4-(4-oxo-2-thioxo-1,4-dihydro-3(2H)-quinazolinyl)butanamide::N-(furan-2-ylmethyl)-4-(4-oxidanylidene-2-sulfanylidene-1H-quinazolin-3-yl)butanamide::N-(furan-2-ylmethyl)-4-(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)butanamide::SMR000076283::cid_866375 Mitogen-activated protein kinase 10 Homo sapiens 49160 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42764&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 866375 252623455 ZINC00425038 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79755 COC(=O)c1ccccc1NC(=O)C1CC(=NO1)c1ccccc1O InChI=1S/C18H16N2O5/c1-24-18(23)12-7-2-4-8-13(12)19-17(22)16-10-14(20-25-16)11-6-3-5-9-15(11)21/h2-9,16,21H,10H2,1H3,(H,19,22) NWOOCYYWBGJGFB-UHFFFAOYSA-N 42765 2-[[(3E)-3-(6-ketocyclohexa-2,4-dien-1-ylidene)isoxazolidine-5-carbonyl]amino]benzoic acid methyl ester::2-[[oxo-[(3E)-3-(6-oxo-1-cyclohexa-2,4-dienylidene)-5-isoxazolidinyl]methyl]amino]benzoic acid methyl ester::MLS000064956::SMR000078275::cid_5771716::methyl 2-({[3-(2-hydroxyphenyl)-4,5-dihydro-5-isoxazolyl]carbonyl}amino)benzoate::methyl 2-[[(3E)-3-(6-oxidanylidenecyclohexa-2,4-dien-1-ylidene)-1,2-oxazolidin-5-yl]carbonylamino]benzoate::methyl 2-[[(3E)-3-(6-oxocyclohexa-2,4-dien-1-ylidene)-1,2-oxazolidine-5-carbonyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 33910 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42765&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5771716 252623456 ZINC13123437 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79756 CCOC(=O)c1c([nH]c2ccc(O)cc12)-c1ccccc1 InChI=1S/C17H15NO3/c1-2-21-17(20)15-13-10-12(19)8-9-14(13)18-16(15)11-6-4-3-5-7-11/h3-10,18-19H,2H2,1H3 LJJGRVZPZCEJHG-UHFFFAOYSA-N 42766 5-hydroxy-2-phenyl-1H-indole-3-carboxylic acid ethyl ester::MLS000052742::SMR000082522::cid_931131::ethyl 5-hydroxy-2-phenyl-1H-indole-3-carboxylate::ethyl 5-oxidanyl-2-phenyl-1H-indole-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 22190 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42766&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 931131 252623457 ZINC00522722 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79757 COC(=O)c1ccccc1NC(=O)c1ccc(NS(C)(=O)=O)cc1 InChI=1S/C16H16N2O5S/c1-23-16(20)13-5-3-4-6-14(13)17-15(19)11-7-9-12(10-8-11)18-24(2,21)22/h3-10,18H,1-2H3,(H,17,19) FZDYBFIAGQNIEJ-UHFFFAOYSA-N 42767 2-[[4-(methanesulfonamido)benzoyl]amino]benzoic acid methyl ester::2-[[[4-(methanesulfonamido)phenyl]-oxomethyl]amino]benzoic acid methyl ester::MLS000051092::SMR000078972::cid_967576::methyl 2-({4-[(methylsulfonyl)amino]benzoyl}amino)benzoate::methyl 2-[[4-(methanesulfonamido)benzoyl]amino]benzoate::methyl 2-[[4-(methylsulfonylamino)phenyl]carbonylamino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 55390 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42767&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 967576 252623458 ZINC00582547 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79758 CCCOc1ccc(cc1)C1C(C(=O)c2ccc(C)o2)C(=O)C(=O)N1CCCn1ccnc1 InChI=1S/C25H27N3O5/c1-3-15-32-19-8-6-18(7-9-19)22-21(23(29)20-10-5-17(2)33-20)24(30)25(31)28(22)13-4-12-27-14-11-26-16-27/h5-11,14,16,21-22H,3-4,12-13,15H2,1-2H3 YQUBVOZUPDHUIH-UHFFFAOYSA-N 37760 1-(3-imidazol-1-ylpropyl)-3-(5-methylfuran-2-yl)carbonyl-4-oxidanyl-2-(4-propoxyphenyl)-2H-pyrrol-5-one::3-hydroxy-1-(3-imidazol-1-ylpropyl)-4-(5-methyl-2-furoyl)-5-(4-propoxyphenyl)-3-pyrrolin-2-one::3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-4-(5-methyl-2-furoyl)-5-(4-propoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one::4-hydroxy-1-(3-imidazol-1-ylpropyl)-3-(5-methylfuran-2-carbonyl)-2-(4-propoxyphenyl)-2H-pyrrol-5-one::4-hydroxy-1-[3-(1-imidazolyl)propyl]-3-[(5-methyl-2-furanyl)-oxomethyl]-2-(4-propoxyphenyl)-2H-pyrrol-5-one::MLS000049447::SMR000075421::cid_2950328 Mitogen-activated protein kinase 10 Homo sapiens 19730 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37760&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896333 252618723 ZINC09042751 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79759 COC(=O)c1sccc1NC(=O)c1ccco1 InChI=1S/C11H9NO4S/c1-15-11(14)9-7(4-6-17-9)12-10(13)8-3-2-5-16-8/h2-6H,1H3,(H,12,13) IXWDIISJEVEBJI-UHFFFAOYSA-N 42768 3-(2-furoylamino)thiophene-2-carboxylic acid methyl ester::3-[[2-furanyl(oxo)methyl]amino]-2-thiophenecarboxylic acid methyl ester::MLS000088421::SMR000071796::cid_897017::methyl 3-(2-furoylamino)-2-thiophenecarboxylate::methyl 3-(furan-2-carbonylamino)thiophene-2-carboxylate::methyl 3-(furan-2-ylcarbonylamino)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42768&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 897017 252623459 ZINC00474602 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79760 Oc1ccccc1C1=Nc2ccccc2N=C(C1)c1ccco1 InChI=1S/C19H14N2O2/c22-18-9-4-1-6-13(18)16-12-17(19-10-5-11-23-19)21-15-8-3-2-7-14(15)20-16/h1-11,22H,12H2 HXZRSRJPFKPHKZ-UHFFFAOYSA-N 42769 (6E)-6-[4-(2-furanyl)-1,3-dihydro-1,5-benzodiazepin-2-ylidene]-1-cyclohexa-2,4-dienone::(6E)-6-[4-(2-furyl)-1,3-dihydro-1,5-benzodiazepin-2-ylidene]cyclohexa-2,4-dien-1-one::(6E)-6-[4-(furan-2-yl)-1,3-dihydro-1,5-benzodiazepin-2-ylidene]cyclohexa-2,4-dien-1-one::2-[4-(2-furyl)-3H-1,5-benzodiazepin-2-yl]phenol::MLS000088632::SMR000072631::cid_5771720 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42769&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5771720 252623460 ZINC13123430 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79761 COC(=O)c1sccc1NC(=O)c1csc(C)c1 InChI=1S/C12H11NO3S2/c1-7-5-8(6-18-7)11(14)13-9-3-4-17-10(9)12(15)16-2/h3-6H,1-2H3,(H,13,14) BUIZWUHTUPUZCX-UHFFFAOYSA-N 42770 3-[(5-methylthiophene-3-carbonyl)amino]thiophene-2-carboxylic acid methyl ester::3-[[(5-methyl-3-thiophenyl)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester::MLS000065788::SMR000080473::cid_1245967::methyl 3-[(5-methylthiophen-3-yl)carbonylamino]thiophene-2-carboxylate::methyl 3-[(5-methylthiophene-3-carbonyl)amino]thiophene-2-carboxylate::methyl 3-{[(5-methyl-3-thienyl)carbonyl]amino}-2-thiophenecarboxylate Mitogen-activated protein kinase 10 Homo sapiens 38540 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42770&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1245967 252623461 ZINC01054502 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79762 Cn1nnnc1SCc1ccc(cc1)C(=O)Nc1nccs1 InChI=1S/C13H12N6OS2/c1-19-13(16-17-18-19)22-8-9-2-4-10(5-3-9)11(20)15-12-14-6-7-21-12/h2-7H,8H2,1H3,(H,14,15,20) MIKIAXCDUOKMNF-UHFFFAOYSA-N 42771 4-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanylmethyl]-N-(1,3-thiazol-2-yl)benzamide::4-[(1-methyltetrazol-5-yl)sulfanylmethyl]-N-(1,3-thiazol-2-yl)benzamide::4-[[(1-methyl-5-tetrazolyl)thio]methyl]-N-(2-thiazolyl)benzamide::4-[[(1-methyltetrazol-5-yl)thio]methyl]-N-thiazol-2-yl-benzamide::4-{[(1-methyl-1H-tetrazol-5-yl)thio]methyl}-N-1,3-thiazol-2-ylbenzamide::MLS000064651::SMR000077370::cid_851623 Mitogen-activated protein kinase 10 Homo sapiens 56860 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42771&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 851623 252623462 ZINC00386488 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79763 O=C(Nc1cccc2C(=O)NC(=O)c12)C1CCCO1 InChI=1S/C13H12N2O4/c16-11-7-3-1-4-8(10(7)13(18)15-11)14-12(17)9-5-2-6-19-9/h1,3-4,9H,2,5-6H2,(H,14,17)(H,15,16,18) NFJLHTYTEFGBPV-UHFFFAOYSA-N 42772 MLS000064410::N-(1,3-diketoisoindolin-4-yl)tetrahydrofuran-2-carboxamide::N-(1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)tetrahydro-2-furancarboxamide::N-(1,3-dioxo-4-isoindolyl)-2-oxolanecarboxamide::N-(1,3-dioxoisoindol-4-yl)oxolane-2-carboxamide::N-[1,3-bis(oxidanylidene)isoindol-4-yl]oxolane-2-carboxamide::SMR000078046::cid_2961755 Mitogen-activated protein kinase 10 Homo sapiens 56160 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42772&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2961755 252623463 ZINC00614266 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79764 CCCCC(=O)Nc1sc2CCCc2c1C(N)=O InChI=1S/C13H18N2O2S/c1-2-3-7-10(16)15-13-11(12(14)17)8-5-4-6-9(8)18-13/h2-7H2,1H3,(H2,14,17)(H,15,16) XGHMYAGRKKGWJD-UHFFFAOYSA-N 42773 2-(1-oxopentylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::2-(pentanoylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::2-(valerylamino)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide::MLS000062467::SMR000073217::cid_2941851 Mitogen-activated protein kinase 10 Homo sapiens 16030 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42773&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2941851 252623464 ZINC04197214 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79765 CCCn1cc(NC(=O)C2CC(=NO2)c2cccc(Br)c2)cn1 InChI=1S/C16H17BrN4O2/c1-2-6-21-10-13(9-18-21)19-16(22)15-8-14(20-23-15)11-4-3-5-12(17)7-11/h3-5,7,9-10,15H,2,6,8H2,1H3,(H,19,22) LEPBIJKMMZXYCE-UHFFFAOYSA-N 42774 3-(3-bromophenyl)-N-(1-propyl-1H-pyrazol-4-yl)-4,5-dihydro-5-isoxazolecarboxamide::3-(3-bromophenyl)-N-(1-propyl-4-pyrazolyl)-4,5-dihydroisoxazole-5-carboxamide::3-(3-bromophenyl)-N-(1-propylpyrazol-4-yl)-2-isoxazoline-5-carboxamide::3-(3-bromophenyl)-N-(1-propylpyrazol-4-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide::MLS000050750::SMR000078273::cid_2962251 Mitogen-activated protein kinase 10 Homo sapiens 7366 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42774&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2962251 252623465 ZINC01126328 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79766 CCOC(=O)c1c(C)[nH]c2ccc(O)cc12 InChI=1S/C12H13NO3/c1-3-16-12(15)11-7(2)13-10-5-4-8(14)6-9(10)11/h4-6,13-14H,3H2,1-2H3 BSNHKSUAAMJXBB-UHFFFAOYSA-N 32211 5-hydroxy-2-methyl-1H-indole-3-carboxylic acid ethyl ester::cid_82073::ethyl 2-methyl-5-oxidanyl-1H-indole-3-carboxylate::ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32211&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 82073 252615659 ZINC00034675 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79767 CC1NC(=O)NC1CCCCCC(=O)Nc1ccc(C)cc1 InChI=1S/C17H25N3O2/c1-12-8-10-14(11-9-12)19-16(21)7-5-3-4-6-15-13(2)18-17(22)20-15/h8-11,13,15H,3-7H2,1-2H3,(H,19,21)(H2,18,20,22) TWUHJIAGJSKONL-UHFFFAOYSA-N 42775 6-(2-keto-5-methyl-imidazolidin-4-yl)-N-(p-tolyl)hexanamide::6-(5-methyl-2-oxidanylidene-imidazolidin-4-yl)-N-(4-methylphenyl)hexanamide::6-(5-methyl-2-oxo-4-imidazolidinyl)-N-(4-methylphenyl)hexanamide::6-(5-methyl-2-oxoimidazolidin-4-yl)-N-(4-methylphenyl)hexanamide::MLS000051846::SMR000080943::cid_2972189 Mitogen-activated protein kinase 10 Homo sapiens 1819 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42775&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2972189 252623466 ZINC02873961 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79768 O=C(Nc1cccc(c1)C(=O)Nc1cccc(c1)-c1nc2ccccc2[nH]1)c1ccco1 InChI=1S/C25H18N4O3/c30-24(17-7-4-9-19(15-17)27-25(31)22-12-5-13-32-22)26-18-8-3-6-16(14-18)23-28-20-10-1-2-11-21(20)29-23/h1-15H,(H,26,30)(H,27,31)(H,28,29) WFJMXMMPYVXLFE-UHFFFAOYSA-N 35417 MLS000089222::N-[3-({[3-(1H-benzimidazol-2-yl)phenyl]amino}carbonyl)phenyl]-2-furamide::N-[3-[[3-(1H-benzimidazol-2-yl)anilino]-oxomethyl]phenyl]-2-furancarboxamide::N-[3-[[3-(1H-benzimidazol-2-yl)phenyl]carbamoyl]phenyl]-2-furamide::N-[3-[[3-(1H-benzimidazol-2-yl)phenyl]carbamoyl]phenyl]furan-2-carboxamide::SMR000072976::cid_2192323 Mitogen-activated protein kinase 10 Homo sapiens 68460 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35417&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2192323 252617684 ZINC02835622 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79769 Fc1cccc(Nc2cc(ncn2)-n2cccn2)c1 InChI=1S/C13H10FN5/c14-10-3-1-4-11(7-10)18-12-8-13(16-9-15-12)19-6-2-5-17-19/h1-9H,(H,15,16,18) BIKLNZVXIPYGJC-UHFFFAOYSA-N 42776 (3-fluorophenyl)-(6-pyrazol-1-ylpyrimidin-4-yl)amine::MLS000058879::N-(3-fluorophenyl)-6-(1-pyrazolyl)-4-pyrimidinamine::N-(3-fluorophenyl)-6-(1H-pyrazol-1-yl)-4-pyrimidinamine::N-(3-fluorophenyl)-6-pyrazol-1-yl-pyrimidin-4-amine::N-(3-fluorophenyl)-6-pyrazol-1-ylpyrimidin-4-amine::SMR000069448::cid_796100 Mitogen-activated protein kinase 10 Homo sapiens 6935 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42776&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 796100 252623467 ZINC00299993 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79770 COC(=O)c1sccc1NC(=O)CN1CCN(CC1)c1ccc(F)cc1 InChI=1S/C18H20FN3O3S/c1-25-18(24)17-15(6-11-26-17)20-16(23)12-21-7-9-22(10-8-21)14-4-2-13(19)3-5-14/h2-6,11H,7-10,12H2,1H3,(H,20,23) MNNAIWDEQUZTQS-UHFFFAOYSA-N 42777 3-[[2-[4-(4-fluorophenyl)-1-piperazinyl]-1-oxoethyl]amino]-2-thiophenecarboxylic acid methyl ester::3-[[2-[4-(4-fluorophenyl)piperazino]acetyl]amino]thiophene-2-carboxylic acid methyl ester::MLS000065233::SMR000078838::cid_1259816::methyl 3-({[4-(4-fluorophenyl)-1-piperazinyl]acetyl}amino)-2-thiophenecarboxylate::methyl 3-[2-[4-(4-fluorophenyl)piperazin-1-yl]ethanoylamino]thiophene-2-carboxylate::methyl 3-[[2-[4-(4-fluorophenyl)piperazin-1-yl]acetyl]amino]thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 15590 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42777&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1259816 252623468 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79771 COC(=O)c1ccccc1NC(=O)NCc1cccnc1 InChI=1S/C15H15N3O3/c1-21-14(19)12-6-2-3-7-13(12)18-15(20)17-10-11-5-4-8-16-9-11/h2-9H,10H2,1H3,(H2,17,18,20) UDZKCTOWFIGASI-UHFFFAOYSA-N 42778 2-(3-pyridylmethylcarbamoylamino)benzoic acid methyl ester::2-[[oxo-(3-pyridinylmethylamino)methyl]amino]benzoic acid methyl ester::MLS000063934::SMR000076825::cid_970862::methyl 2-(pyridin-3-ylmethylcarbamoylamino)benzoate::methyl 2-({[(3-pyridinylmethyl)amino]carbonyl}amino)benzoate Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42778&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 970862 252623469 ZINC00610450 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79772 CCOC(=O)c1ccccc1NC(=O)c1ccc(NS(C)(=O)=O)cc1 InChI=1S/C17H18N2O5S/c1-3-24-17(21)14-6-4-5-7-15(14)18-16(20)12-8-10-13(11-9-12)19-25(2,22)23/h4-11,19H,3H2,1-2H3,(H,18,20) RCBJVJJWVHGECT-UHFFFAOYSA-N 42779 2-[[4-(methanesulfonamido)benzoyl]amino]benzoic acid ethyl ester::2-[[[4-(methanesulfonamido)phenyl]-oxomethyl]amino]benzoic acid ethyl ester::MLS000050790::SMR000078380::cid_1289497::ethyl 2-({4-[(methylsulfonyl)amino]benzoyl}amino)benzoate::ethyl 2-[[4-(methanesulfonamido)benzoyl]amino]benzoate::ethyl 2-[[4-(methylsulfonylamino)phenyl]carbonylamino]benzoate Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42779&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1289497 252623470 ZINC01111060 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79773 COc1ccc(CC(=O)Nc2cc(C)ccn2)cc1 InChI=1S/C15H16N2O2/c1-11-7-8-16-14(9-11)17-15(18)10-12-3-5-13(19-2)6-4-12/h3-9H,10H2,1-2H3,(H,16,17,18) HHVSOSFUQWVKCH-UHFFFAOYSA-N 42780 2-(4-methoxyphenyl)-N-(4-methyl-2-pyridinyl)acetamide::2-(4-methoxyphenyl)-N-(4-methyl-2-pyridyl)acetamide::2-(4-methoxyphenyl)-N-(4-methylpyridin-2-yl)acetamide::2-(4-methoxyphenyl)-N-(4-methylpyridin-2-yl)ethanamide::MLS000058869::SMR000069438::cid_795395 Mitogen-activated protein kinase 10 Homo sapiens 21370 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42780&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 795395 252623471 ZINC00299027 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79774 CN(c1ccc(cc1)C(=O)Nc1nccs1)S(=O)(=O)c1ccccc1 InChI=1S/C17H15N3O3S2/c1-20(25(22,23)15-5-3-2-4-6-15)14-9-7-13(8-10-14)16(21)19-17-18-11-12-24-17/h2-12H,1H3,(H,18,19,21) LJZYYSIPPKMYER-UHFFFAOYSA-N 18444 4-[benzene(methyl)sulfonamido]-N-(1,3-thiazol-2-yl)benzamide::Sulfonamide analogue, 24::cid_1309992 Mitogen-activated protein kinase 10 Homo sapiens 46920 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18444&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1309992 46518518 ZINC01135999 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79775 N(c1ccccn1)c1ccccc1Nc1ccccn1 InChI=1S/C16H14N4/c1-2-8-14(20-16-10-4-6-12-18-16)13(7-1)19-15-9-3-5-11-17-15/h1-12H,(H,17,19)(H,18,20) SOKRFGDZIFVBTM-UHFFFAOYSA-N 42781 1-N,2-N-dipyridin-2-ylbenzene-1,2-diamine::2-pyridinyl[2-(2-pyridinylamino)phenyl]amine::2-pyridyl-[2-(2-pyridylamino)phenyl]amine::MLS000059187::N1,N2-bis(2-pyridinyl)benzene-1,2-diamine::N1,N2-dipyridin-2-ylbenzene-1,2-diamine::SMR000069559::cid_691990 Mitogen-activated protein kinase 10 Homo sapiens 18440 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42781&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 691990 252623472 ZINC00063328 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79776 c1csc(c1)-c1cnc2ccccc2n1 InChI=1S/C12H8N2S/c1-2-5-10-9(4-1)13-8-11(14-10)12-6-3-7-15-12/h1-8H ADGDUIDDAMQKAG-UHFFFAOYSA-N 42782 2-(2-thienyl)quinoxaline::2-thiophen-2-ylquinoxaline::MLS000053037::SMR000069000::cid_251141 Mitogen-activated protein kinase 10 Homo sapiens 33970 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42782&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 251141 252623473 ZINC00040516 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79777 NC(=O)c1c(NC(=O)C2CCCO2)sc2CCCc12 InChI=1S/C13H16N2O3S/c14-11(16)10-7-3-1-5-9(7)19-13(10)15-12(17)8-4-2-6-18-8/h8H,1-6H2,(H2,14,16)(H,15,17) RFMLAKZJWGLPEF-UHFFFAOYSA-N 42783 MLS000065653::N-(3-aminocarbonyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)oxolane-2-carboxamide::N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-oxolanecarboxamide::N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)oxolane-2-carboxamide::N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)tetrahydrofuran-2-carboxamide::N-[3-(aminocarbonyl)-5,6-dihydro-4H-cyclopenta[b]thien-2-yl]tetrahydro-2-furancarboxamide::SMR000080296::cid_2970466 Mitogen-activated protein kinase 10 Homo sapiens 42500 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42783&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2970466 252623474 ZINC04195956 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79778 CN1CCN(CC1)c1ccccc1NC(=O)c1ccc(Br)o1 InChI=1S/C16H18BrN3O2/c1-19-8-10-20(11-9-19)13-5-3-2-4-12(13)18-16(21)14-6-7-15(17)22-14/h2-7H,8-11H2,1H3,(H,18,21) SWJZESQMXHBAAK-UHFFFAOYSA-N 42784 5-bromanyl-N-[2-(4-methylpiperazin-1-yl)phenyl]furan-2-carboxamide::5-bromo-N-[2-(4-methyl-1-piperazinyl)phenyl]-2-furamide::5-bromo-N-[2-(4-methyl-1-piperazinyl)phenyl]-2-furancarboxamide::5-bromo-N-[2-(4-methylpiperazin-1-yl)phenyl]furan-2-carboxamide::5-bromo-N-[2-(4-methylpiperazino)phenyl]-2-furamide::MLS000065957::SMR000079340::cid_2222160 Mitogen-activated protein kinase 10 Homo sapiens 10270 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42784&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2222160 252623475 ZINC02869021 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79779 Nc1nc2CCCCCc2c(-c2ccco2)c1C#N InChI=1S/C15H15N3O/c16-9-11-14(13-7-4-8-19-13)10-5-2-1-3-6-12(10)18-15(11)17/h4,7-8H,1-3,5-6H2,(H2,17,18) UUSRACGROVEGPY-UHFFFAOYSA-N 42785 2-amino-4-(2-furanyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile::2-amino-4-(2-furyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile::2-amino-4-(furan-2-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile::2-azanyl-4-(furan-2-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile::MLS000053108::SMR000069375::cid_754321 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42785&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 754321 252623476 ZINC19594869 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79780 CC(=O)Nc1cccc(c1)-c1nc2ccccc2c(=O)o1 InChI=1S/C16H12N2O3/c1-10(19)17-12-6-4-5-11(9-12)15-18-14-8-3-2-7-13(14)16(20)21-15/h2-9H,1H3,(H,17,19) XSBOJWUPSZFPAH-UHFFFAOYSA-N 37437 MLS000061720::N-[3-(4-keto-3,1-benzoxazin-2-yl)phenyl]acetamide::N-[3-(4-oxidanylidene-3,1-benzoxazin-2-yl)phenyl]ethanamide::N-[3-(4-oxo-3,1-benzoxazin-2-yl)phenyl]acetamide::N-[3-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]acetamide::SMR000070188::cid_693837 Mitogen-activated protein kinase 10 Homo sapiens 41950 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=37437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=37437&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 693837 252618408 ZINC00066258 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79781 COCCNC(=O)C1CCC(Cn2c(=S)[nH]c3ccccc3c2=O)CC1 InChI=1S/C19H25N3O3S/c1-25-11-10-20-17(23)14-8-6-13(7-9-14)12-22-18(24)15-4-2-3-5-16(15)21-19(22)26/h2-5,13-14H,6-12H2,1H3,(H,20,23)(H,21,26) KFXLQROCBSAZFL-UHFFFAOYSA-N 42786 4-[(4-keto-2-thioxo-1H-quinazolin-3-yl)methyl]-N-(2-methoxyethyl)cyclohexanecarboxamide::MLS000049675::N-(2-methoxyethyl)-4-[(4-oxidanylidene-2-sulfanylidene-1H-quinazolin-3-yl)methyl]cyclohexane-1-carboxamide::N-(2-methoxyethyl)-4-[(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)methyl]-1-cyclohexanecarboxamide::N-(2-methoxyethyl)-4-[(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)methyl]cyclohexane-1-carboxamide::N-(2-methoxyethyl)-4-[(4-oxo-2-thioxo-1,4-dihydro-3(2H)-quinazolinyl)methyl]cyclohexanecarboxamide::SMR000076293::cid_2953401 Mitogen-activated protein kinase 10 Homo sapiens 9757 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42786&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2953401 252623477 ZINC04014254 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79782 CC(=O)c1sc2nc(SCC(=O)N3CCCCC3)[nH]c(=O)c2c1C InChI=1S/C16H19N3O3S2/c1-9-12-14(22)17-16(18-15(12)24-13(9)10(2)20)23-8-11(21)19-6-4-3-5-7-19/h3-8H2,1-2H3,(H,17,18,22) PLBWVSJDZDWQGO-UHFFFAOYSA-N 40642 1-(4-hydroxy-5-methyl-2-{[2-oxo-2-(1-piperidinyl)ethyl]thio}thieno[2,3-d]pyrimidin-6-yl)ethanone::6-acetyl-2-[(2-keto-2-piperidino-ethyl)thio]-5-methyl-3H-thieno[2,3-d]pyrimidin-4-one::6-acetyl-5-methyl-2-(2-oxo-2-piperidin-1-ylethyl)sulfanyl-3H-thieno[2,3-d]pyrimidin-4-one::6-acetyl-5-methyl-2-[[2-oxo-2-(1-piperidinyl)ethyl]thio]-3H-thieno[2,3-d]pyrimidin-4-one::6-ethanoyl-5-methyl-2-(2-oxidanylidene-2-piperidin-1-yl-ethyl)sulfanyl-3H-thieno[2,3-d]pyrimidin-4-one::MLS000066010::SMR000079445::cid_2222525 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40642&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2222525 252621462 ZINC08619707 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79783 C(Cn1c2ccccc2c2nc3ccccc3nc12)N1CCOCC1 InChI=1S/C20H20N4O/c1-4-8-18-15(5-1)19-20(22-17-7-3-2-6-16(17)21-19)24(18)10-9-23-11-13-25-14-12-23/h1-8H,9-14H2 MFVLXWUDVQMAHA-UHFFFAOYSA-N 39493 4-(2-indolo[3,2-b]quinoxalin-6-ylethyl)morpholine::4-[2-(6-indolo[3,2-b]quinoxalinyl)ethyl]morpholine::6-[2-(4-morpholinyl)ethyl]-6H-indolo[2,3-b]quinoxaline::MLS000062353::SMR000072962::cid_752314 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39493&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 752314 252620385 ZINC19727275 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79784 COC(=O)c1ccsc1NC(=O)CN1CCN(CC1)c1ccc(F)cc1 InChI=1S/C18H20FN3O3S/c1-25-18(24)15-6-11-26-17(15)20-16(23)12-21-7-9-22(10-8-21)14-4-2-13(19)3-5-14/h2-6,11H,7-10,12H2,1H3,(H,20,23) WPEBMQUXUKAVQS-UHFFFAOYSA-N 42787 2-[[2-[4-(4-fluorophenyl)-1-piperazinyl]-1-oxoethyl]amino]-3-thiophenecarboxylic acid methyl ester::2-[[2-[4-(4-fluorophenyl)piperazino]acetyl]amino]thiophene-3-carboxylic acid methyl ester::MLS000066200::SMR000079814::cid_1265862::methyl 2-({[4-(4-fluorophenyl)-1-piperazinyl]acetyl}amino)-3-thiophenecarboxylate::methyl 2-[2-[4-(4-fluorophenyl)piperazin-1-yl]ethanoylamino]thiophene-3-carboxylate::methyl 2-[[2-[4-(4-fluorophenyl)piperazin-1-yl]acetyl]amino]thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 15590 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42787&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1265862 252623478 ZINC36040327 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79785 CS(=O)(=O)N1CCN(CC1)c1ccccc1NC(=O)CSc1ccc(Cl)cc1 InChI=1S/C19H22ClN3O3S2/c1-28(25,26)23-12-10-22(11-13-23)18-5-3-2-4-17(18)21-19(24)14-27-16-8-6-15(20)7-9-16/h2-9H,10-14H2,1H3,(H,21,24) CULQEFVJYMPVNH-UHFFFAOYSA-N 42788 2-(4-chlorophenyl)sulfanyl-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]acetamide::2-(4-chlorophenyl)sulfanyl-N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]ethanamide::2-[(4-chlorophenyl)thio]-N-[2-(4-mesylpiperazino)phenyl]acetamide::2-[(4-chlorophenyl)thio]-N-[2-(4-methylsulfonyl-1-piperazinyl)phenyl]acetamide::2-[(4-chlorophenyl)thio]-N-{2-[4-(methylsulfonyl)-1-piperazinyl]phenyl}acetamide::MLS000050984::SMR000078736::cid_2963778 Mitogen-activated protein kinase 10 Homo sapiens 90470 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42788&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2963778 252623479 ZINC04058269 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79786 CCOC(=O)c1c(CC(C)C)csc1NC(C)=O InChI=1S/C13H19NO3S/c1-5-17-13(16)11-10(6-8(2)3)7-18-12(11)14-9(4)15/h7-8H,5-6H2,1-4H3,(H,14,15) OGOQIEBMFLOHAE-UHFFFAOYSA-N 42789 2-acetamido-4-(2-methylpropyl)-3-thiophenecarboxylic acid ethyl ester::2-acetamido-4-isobutyl-thiophene-3-carboxylic acid ethyl ester::MLS000061685::SMR000070020::cid_786596::ethyl 2-(acetylamino)-4-isobutyl-3-thiophenecarboxylate::ethyl 2-acetamido-4-(2-methylpropyl)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42789&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 786596 252623480 ZINC00284135 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79787 COc1ccc(OC)c(Nc2nc(N)nc(n2)-c2cc3ccccc3o2)c1 InChI=1S/C19H17N5O3/c1-25-12-7-8-15(26-2)13(10-12)21-19-23-17(22-18(20)24-19)16-9-11-5-3-4-6-14(11)27-16/h3-10H,1-2H3,(H3,20,21,22,23,24) HKAKSIDZHIMZEE-UHFFFAOYSA-N 42790 6-(1-benzofuran-2-yl)-2-N-(2,5-dimethoxyphenyl)-1,3,5-triazine-2,4-diamine::6-(1-benzofuran-2-yl)-N-(2,5-dimethoxyphenyl)-1,3,5-triazine-2,4-diamine::6-(1-benzofuran-2-yl)-N2-(2,5-dimethoxyphenyl)-1,3,5-triazine-2,4-diamine::6-(2-benzofuranyl)-N2-(2,5-dimethoxyphenyl)-1,3,5-triazine-2,4-diamine::MLS000052886::SMR000082725::[4-amino-6-(benzofuran-2-yl)-s-triazin-2-yl]-(2,5-dimethoxyphenyl)amine::cid_1942568 Mitogen-activated protein kinase 10 Homo sapiens 47810 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42790&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1942568 252623481 ZINC16974556 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79788 COc1ccc(cc1OC)C(=O)n1nc(nc1N)-c1ccccc1 InChI=1S/C17H16N4O3/c1-23-13-9-8-12(10-14(13)24-2)16(22)21-17(18)19-15(20-21)11-6-4-3-5-7-11/h3-10H,1-2H3,(H2,18,19,20) KJFHJZMOFADPOP-UHFFFAOYSA-N 33437 (5-amino-3-phenyl-1,2,4-triazol-1-yl)-(3,4-dimethoxyphenyl)methanone::(5-azanyl-3-phenyl-1,2,4-triazol-1-yl)-(3,4-dimethoxyphenyl)methanone::1-(3,4-dimethoxybenzoyl)-3-phenyl-1H-1,2,4-triazol-5-amine::MLS000099650::SMR000074479::cid_975107 Mitogen-activated protein kinase 10 Homo sapiens 19180 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=33437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=33437&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 975107 252616345 ZINC00616457 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79789 CCc1cc(=O)oc2cc(C)cc(OC(=O)c3ccco3)c12 InChI=1S/C17H14O5/c1-3-11-9-15(18)21-13-7-10(2)8-14(16(11)13)22-17(19)12-5-4-6-20-12/h4-9H,3H2,1-2H3 NNRFLFDXJXSWIV-UHFFFAOYSA-N 32673 (4-ethyl-7-methyl-2-oxidanylidene-chromen-5-yl) furan-2-carboxylate::(4-ethyl-7-methyl-2-oxochromen-5-yl) furan-2-carboxylate::2-furancarboxylic acid (4-ethyl-7-methyl-2-oxo-1-benzopyran-5-yl) ester::4-ethyl-7-methyl-2-oxo-2H-chromen-5-yl 2-furoate::MLS000099547::SMR000071303::cid_1121645::furan-2-carboxylic acid (4-ethyl-2-keto-7-methyl-chromen-5-yl) ester Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32673&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1121645 252615811 ZINC00859298 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79790 Fc1ccc(CSc2nc(-c3ccco3)c(C#N)c(=O)[nH]2)cc1 InChI=1S/C16H10FN3O2S/c17-11-5-3-10(4-6-11)9-23-16-19-14(13-2-1-7-22-13)12(8-18)15(21)20-16/h1-7H,9H2,(H,19,20,21) DXRLBFPEYLCEPQ-UHFFFAOYSA-N 42791 2-[(4-fluorobenzyl)thio]-4-(2-furyl)-6-oxo-1,6-dihydro-5-pyrimidinecarbonitrile::2-[(4-fluorobenzyl)thio]-6-(2-furyl)-4-keto-1H-pyrimidine-5-carbonitrile::2-[(4-fluorophenyl)methylsulfanyl]-6-(furan-2-yl)-4-oxidanylidene-1H-pyrimidine-5-carbonitrile::2-[(4-fluorophenyl)methylsulfanyl]-6-(furan-2-yl)-4-oxo-1H-pyrimidine-5-carbonitrile::2-[(4-fluorophenyl)methylthio]-6-(2-furanyl)-4-oxo-1H-pyrimidine-5-carbonitrile::MLS000065058::SMR000078436::cid_974019 Mitogen-activated protein kinase 10 Homo sapiens 13640 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42791&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 974019 252623482 ZINC08763110 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79791 Cc1ccccc1NC(=O)c1[nH]cnc1C(=O)NCc1ccccc1 InChI=1S/C19H18N4O2/c1-13-7-5-6-10-15(13)23-19(25)17-16(21-12-22-17)18(24)20-11-14-8-3-2-4-9-14/h2-10,12H,11H2,1H3,(H,20,24)(H,21,22)(H,23,25) GRERGNBRPOSGPD-UHFFFAOYSA-N 42792 5-N-benzyl-4-N-(2-methylphenyl)-1H-imidazole-4,5-dicarboxamide::MLS000099497::N'-benzyl-N-(o-tolyl)-1H-imidazole-4,5-dicarboxamide::N4-(2-methylphenyl)-N5-(phenylmethyl)-1H-imidazole-4,5-dicarboxamide::N~5~-benzyl-N~4~-(2-methylphenyl)-1H-imidazole-4,5-dicarboxamide::SMR000074150::cid_965339 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42792&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 965339 252623483 ZINC87711565 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79792 CCCC(=O)Nc1ccc(Cl)c(NC(=O)c2ccc(Br)o2)c1 InChI=1S/C15H14BrClN2O3/c1-2-3-14(20)18-9-4-5-10(17)11(8-9)19-15(21)12-6-7-13(16)22-12/h4-8H,2-3H2,1H3,(H,18,20)(H,19,21) IPIQQTWBUMLHSQ-UHFFFAOYSA-N 42793 5-bromanyl-N-[5-(butanoylamino)-2-chloranyl-phenyl]furan-2-carboxamide::5-bromo-N-(5-butyramido-2-chloro-phenyl)-2-furamide::5-bromo-N-[2-chloro-5-(1-oxobutylamino)phenyl]-2-furancarboxamide::5-bromo-N-[5-(butanoylamino)-2-chlorophenyl]furan-2-carboxamide::5-bromo-N-[5-(butyrylamino)-2-chlorophenyl]-2-furamide::MLS000089149::SMR000072846::cid_1286189 Mitogen-activated protein kinase 10 Homo sapiens 37350 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42793&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1286189 252623484 ZINC01107003 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79793 Brc1ccc(o1)C(=O)Nc1ccccc1N1CCOCC1 InChI=1S/C15H15BrN2O3/c16-14-6-5-13(21-14)15(19)17-11-3-1-2-4-12(11)18-7-9-20-10-8-18/h1-6H,7-10H2,(H,17,19) CLXUHLBNKWJORM-UHFFFAOYSA-N 42794 5-bromanyl-N-(2-morpholin-4-ylphenyl)furan-2-carboxamide::5-bromo-N-(2-morpholin-4-ylphenyl)furan-2-carboxamide::5-bromo-N-(2-morpholinophenyl)-2-furamide::5-bromo-N-[2-(4-morpholinyl)phenyl]-2-furamide::5-bromo-N-[2-(4-morpholinyl)phenyl]-2-furancarboxamide::MLS000063094::SMR000072083::cid_1294440 Mitogen-activated protein kinase 10 Homo sapiens 6331 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42794&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1294440 252623485 ZINC01116992 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79794 Brc1ccccc1OCc1ccc(o1)C(=O)Nc1cccnc1 InChI=1S/C17H13BrN2O3/c18-14-5-1-2-6-15(14)22-11-13-7-8-16(23-13)17(21)20-12-4-3-9-19-10-12/h1-10H,11H2,(H,20,21) BIOXSNWBJLKXSP-UHFFFAOYSA-N 42795 5-[(2-bromanylphenoxy)methyl]-N-pyridin-3-yl-furan-2-carboxamide::5-[(2-bromophenoxy)methyl]-N-(3-pyridinyl)-2-furancarboxamide::5-[(2-bromophenoxy)methyl]-N-(3-pyridyl)-2-furamide::5-[(2-bromophenoxy)methyl]-N-3-pyridinyl-2-furamide::5-[(2-bromophenoxy)methyl]-N-pyridin-3-ylfuran-2-carboxamide::MLS000063436::SMR000072862::cid_1223128 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42795&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1223128 252623486 ZINC00998974 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79795 COc1cc(NC(=O)c2ccc(COc3ccccc3Br)o2)cc(OC)c1OC InChI=1S/C21H20BrNO6/c1-25-18-10-13(11-19(26-2)20(18)27-3)23-21(24)17-9-8-14(29-17)12-28-16-7-5-4-6-15(16)22/h4-11H,12H2,1-3H3,(H,23,24) NXXNVRTZCWKFAL-UHFFFAOYSA-N 42796 5-[(2-bromanylphenoxy)methyl]-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide::5-[(2-bromophenoxy)methyl]-N-(3,4,5-trimethoxyphenyl)-2-furamide::5-[(2-bromophenoxy)methyl]-N-(3,4,5-trimethoxyphenyl)-2-furancarboxamide::5-[(2-bromophenoxy)methyl]-N-(3,4,5-trimethoxyphenyl)furan-2-carboxamide::MLS000088938::SMR000073182::cid_1223141 Mitogen-activated protein kinase 10 Homo sapiens 32990 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42796&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1223141 252623487 ZINC00998991 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79796 Cn1c2c3cnc4ccccc4n3c(-c3ccccc3)c2c(=O)n(C)c1=O InChI=1S/C21H16N4O2/c1-23-19-16-12-22-14-10-6-7-11-15(14)25(16)18(13-8-4-3-5-9-13)17(19)20(26)24(2)21(23)27/h3-12H,1-2H3 YVZVATKCIBNZNI-UHFFFAOYSA-N 42797 7,9-dimethyl-11-phenylpyrimido[4',5':3,4]pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-dione::MLS000049242::SMR000075020::cid_1087003 Mitogen-activated protein kinase 10 Homo sapiens 9247 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42797&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1087003 242053030 ZINC00804801 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79797 COc1ccccc1-c1nnc(S)o1 InChI=1S/C9H8N2O2S/c1-12-7-5-3-2-4-6(7)8-10-11-9(14)13-8/h2-5H,1H3,(H,11,14) DVGHKLUHJSFLIT-UHFFFAOYSA-N 42798 5-(2-methoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione::5-(2-methoxyphenyl)-3H-1,3,4-oxadiazole-2-thione::MLS000061368::SMR000070627::cid_749967 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42798&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 749967 252623488 ZINC03886693 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79798 NC(=O)c1ccsc1NC(=O)COc1ccccc1 InChI=1S/C13H12N2O3S/c14-12(17)10-6-7-19-13(10)15-11(16)8-18-9-4-2-1-3-5-9/h1-7H,8H2,(H2,14,17)(H,15,16) SWAFHENUJXWEAO-UHFFFAOYSA-N 42799 2-(2-phenoxyethanoylamino)thiophene-3-carboxamide::2-[(1-oxo-2-phenoxyethyl)amino]-3-thiophenecarboxamide::2-[(2-phenoxyacetyl)amino]thiophene-3-carboxamide::2-[(phenoxyacetyl)amino]-3-thiophenecarboxamide::MLS000065816::SMR000080505::cid_1246150 Mitogen-activated protein kinase 10 Homo sapiens 37580 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42799&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1246150 252623489 ZINC01054715 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79799 CCCCC(=O)Nc1cccc(NC(=O)c2ccc(Br)o2)c1 InChI=1S/C16H17BrN2O3/c1-2-3-7-15(20)18-11-5-4-6-12(10-11)19-16(21)13-8-9-14(17)22-13/h4-6,8-10H,2-3,7H2,1H3,(H,18,20)(H,19,21) ASJZVKGSNABNCB-UHFFFAOYSA-N 42800 5-bromanyl-N-[3-(pentanoylamino)phenyl]furan-2-carboxamide::5-bromo-N-[3-(1-oxopentylamino)phenyl]-2-furancarboxamide::5-bromo-N-[3-(pentanoylamino)phenyl]-2-furamide::5-bromo-N-[3-(pentanoylamino)phenyl]furan-2-carboxamide::5-bromo-N-[3-(valerylamino)phenyl]-2-furamide::MLS000088599::SMR000072587::cid_2189197 Mitogen-activated protein kinase 10 Homo sapiens 37900 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42800&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2189197 252623490 ZINC02831027 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79800 Cc1nn(C)cc1CNC(=O)c1cnn2c(cc(nc12)C1CC1)C(F)F InChI=1S/C17H18F2N6O/c1-9-11(8-24(2)23-9)6-20-17(26)12-7-21-25-14(15(18)19)5-13(10-3-4-10)22-16(12)25/h5,7-8,10,15H,3-4,6H2,1-2H3,(H,20,26) RNKOMDFCDSZMCR-UHFFFAOYSA-N 42801 5-cyclopropyl-7-(difluoromethyl)-N-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide::5-cyclopropyl-7-(difluoromethyl)-N-[(1,3-dimethyl-4-pyrazolyl)methyl]-3-pyrazolo[1,5-a]pyrimidinecarboxamide::5-cyclopropyl-7-(difluoromethyl)-N-[(1,3-dimethylpyrazol-4-yl)methyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide::7-[bis(fluoranyl)methyl]-5-cyclopropyl-N-[(1,3-dimethylpyrazol-4-yl)methyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide::MLS000066699::SMR000082078::cid_1256693 Mitogen-activated protein kinase 10 Homo sapiens 26810 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42801&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1256693 252623491 ZINC01067903 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79801 N#CCCC12CCCCC1=Nc1ccccc21 InChI=1S/C15H16N2/c16-11-5-10-15-9-4-3-8-14(15)17-13-7-2-1-6-12(13)15/h1-2,6-7H,3-5,8-10H2 DGDHJLWUOXGJCM-UHFFFAOYSA-N 42802 3-(1,2,3,4-tetrahydro-4aH-carbazol-4a-yl)propanenitrile::3-(1,2,3,4-tetrahydrocarbazol-4a-yl)propanenitrile::3-(1,2,3,4-tetrahydrocarbazol-4a-yl)propionitrile::MLS000052957::SMR000068914::cid_2826978 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42802&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2826978 252623492 ZINC04011659 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79802 CCOC(=O)c1c(N)[nH]nc1-c1ccc(OC)cc1 InChI=1S/C13H15N3O3/c1-3-19-13(17)10-11(15-16-12(10)14)8-4-6-9(18-2)7-5-8/h4-7H,3H2,1-2H3,(H3,14,15,16) WPZITEXDAIWCGF-UHFFFAOYSA-N 14784 Pyrazole carboxylic ester 7::cid_707658::ethyl 3-amino-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 63060 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14784&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 707658 46515108 ZINC18181314 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79803 O=c1[nH]c(=S)c2CCCc2n1-c1ccccc1 InChI=1S/C13H12N2OS/c16-13-14-12(17)10-7-4-8-11(10)15(13)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,14,16,17) ZQPGVNGOSNPLPX-UHFFFAOYSA-N 42803 1-phenyl-4-sulfanylidene-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-one::1-phenyl-4-thioxo-1,3,4,5,6,7-hexahydro-2H-cyclopenta[d]pyrimidin-2-one::1-phenyl-4-thioxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-2-one::MLS000048158::SMR000073381::cid_893043 Mitogen-activated protein kinase 10 Homo sapiens 76050 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42803&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 893043 252623493 ZINC00469354 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79804 COC(=O)c1sccc1NC(=O)c1ccncc1 InChI=1S/C12H10N2O3S/c1-17-12(16)10-9(4-7-18-10)14-11(15)8-2-5-13-6-3-8/h2-7H,1H3,(H,14,15) ODZDKAIBGWBEQC-UHFFFAOYSA-N 42804 3-[[oxo(pyridin-4-yl)methyl]amino]-2-thiophenecarboxylic acid methyl ester::3-isonicotinamidothiophene-2-carboxylic acid methyl ester::MLS000066842::SMR000071877::cid_897624::methyl 3-(isonicotinoylamino)-2-thiophenecarboxylate::methyl 3-(pyridin-4-ylcarbonylamino)thiophene-2-carboxylate::methyl 3-(pyridine-4-carbonylamino)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 33280 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42804&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 897624 252623494 ZINC00475360 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79805 COC(=O)c1sccc1NC(=O)C1CC=CCC1C(O)=O InChI=1S/C14H15NO5S/c1-20-14(19)11-10(6-7-21-11)15-12(16)8-4-2-3-5-9(8)13(17)18/h2-3,6-9H,4-5H2,1H3,(H,15,16)(H,17,18) NCLPSSAAUMRJND-UHFFFAOYSA-N 42805 6-({[2-(methoxycarbonyl)-3-thienyl]amino}carbonyl)-3-cyclohexene-1-carboxylic acid::6-[(2-carbomethoxy-3-thienyl)carbamoyl]cyclohex-3-ene-1-carboxylic acid::6-[(2-methoxycarbonylthiophen-3-yl)carbamoyl]cyclohex-3-ene-1-carboxylic acid::6-[[(2-methoxycarbonyl-3-thiophenyl)amino]-oxomethyl]-1-cyclohex-3-enecarboxylic acid::MLS000088394::SMR000071767::cid_2931382 Mitogen-activated protein kinase 10 Homo sapiens 19790 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42805&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2931382 252623495 ZINC00474320 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79806 Cc1cccc(c1)-n1ncc2c(NCc3cccs3)ncnc12 InChI=1S/C17H15N5S/c1-12-4-2-5-13(8-12)22-17-15(10-21-22)16(19-11-20-17)18-9-14-6-3-7-23-14/h2-8,10-11H,9H2,1H3,(H,18,19,20) BFSBRCXTSOQXCA-UHFFFAOYSA-N 42806 1-(3-methylphenyl)-N-(2-thienylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::1-(3-methylphenyl)-N-(thiophen-2-ylmethyl)-4-pyrazolo[3,4-d]pyrimidinamine::1-(3-methylphenyl)-N-(thiophen-2-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine::MLS000062383::SMR000073055::[1-(m-tolyl)pyrazolo[3,4-d]pyrimidin-4-yl]-(2-thenyl)amine::cid_892027 Mitogen-activated protein kinase 10 Homo sapiens 72000 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42806&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 892027 252623496 ZINC00467845 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79807 CCOC(=O)c1ccc(Cn2cnc3ccccc3c2=O)cc1 InChI=1S/C18H16N2O3/c1-2-23-18(22)14-9-7-13(8-10-14)11-20-12-19-16-6-4-3-5-15(16)17(20)21/h3-10,12H,2,11H2,1H3 AZUWASSGAPBLGR-UHFFFAOYSA-N 42807 4-[(4-ketoquinazolin-3-yl)methyl]benzoic acid ethyl ester::4-[(4-oxo-3-quinazolinyl)methyl]benzoic acid ethyl ester::MLS000064146::SMR000076057::cid_977664::ethyl 4-[(4-oxidanylidenequinazolin-3-yl)methyl]benzoate::ethyl 4-[(4-oxo-3(4H)-quinazolinyl)methyl]benzoate::ethyl 4-[(4-oxoquinazolin-3-yl)methyl]benzoate Mitogen-activated protein kinase 10 Homo sapiens 12270 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42807&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 977664 252623497 ZINC00620546 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79808 NC(=O)c1cc(Cc2ccccc2)sc1NC(=O)c1ccco1 InChI=1S/C17H14N2O3S/c18-15(20)13-10-12(9-11-5-2-1-3-6-11)23-17(13)19-16(21)14-7-4-8-22-14/h1-8,10H,9H2,(H2,18,20)(H,19,21) CHERUBJRJGWGFE-UHFFFAOYSA-N 42808 MLS000065764::N-(5-benzyl-3-carbamoyl-2-thienyl)-2-furamide::N-(5-benzyl-3-carbamoylthiophen-2-yl)furan-2-carboxamide::N-[3-(aminocarbonyl)-5-benzyl-2-thienyl]-2-furamide::N-[3-aminocarbonyl-5-(phenylmethyl)thiophen-2-yl]furan-2-carboxamide::N-[3-carbamoyl-5-(phenylmethyl)-2-thiophenyl]-2-furancarboxamide::SMR000080445::cid_1245872 Mitogen-activated protein kinase 10 Homo sapiens 4535 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42808&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1245872 252623498 ZINC01054379 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79809 CCOc1ccc(cc1C)S(=O)(=O)n1nnc2ccccc12 InChI=1S/C15H15N3O3S/c1-3-21-15-9-8-12(10-11(15)2)22(19,20)18-14-7-5-4-6-13(14)16-17-18/h4-10H,3H2,1-2H3 OPJXNEFUTWTDNH-UHFFFAOYSA-N 42809 1-(4-ethoxy-3-methyl-phenyl)sulfonylbenzotriazole::1-(4-ethoxy-3-methylphenyl)sulfonylbenzotriazole::1-[(4-ethoxy-3-methylphenyl)sulfonyl]-1H-1,2,3-benzotriazole::MLS000066157::SMR000079737::cid_935119 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42809&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 935119 252623499 ZINC00528624 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79810 Fc1cc2nccnc2cc1N1CCSCC1 InChI=1S/C12H12FN3S/c13-9-7-10-11(15-2-1-14-10)8-12(9)16-3-5-17-6-4-16/h1-2,7-8H,3-6H2 KSJZWKSCTHTCOB-UHFFFAOYSA-N 42810 4-(7-fluoranylquinoxalin-6-yl)thiomorpholine::4-(7-fluoro-6-quinoxalinyl)thiomorpholine::4-(7-fluoroquinoxalin-6-yl)thiomorpholine::6-fluoro-7-(4-thiomorpholinyl)quinoxaline::MLS000050349::SMR000077609::cid_972783 Mitogen-activated protein kinase 10 Homo sapiens 50200 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42810&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 972783 252623500 ZINC00613140 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79811 O=C(CCn1cnc2ccccc2c1=O)Nc1ccc(cc1)S(=O)(=O)N1CCCC1 InChI=1S/C21H22N4O4S/c26-20(11-14-24-15-22-19-6-2-1-5-18(19)21(24)27)23-16-7-9-17(10-8-16)30(28,29)25-12-3-4-13-25/h1-2,5-10,15H,3-4,11-14H2,(H,23,26) QWSQDLDPYSCHEK-UHFFFAOYSA-N 42811 3-(4-ketoquinazolin-3-yl)-N-(4-pyrrolidinosulfonylphenyl)propionamide::3-(4-oxidanylidenequinazolin-3-yl)-N-(4-pyrrolidin-1-ylsulfonylphenyl)propanamide::3-(4-oxo-3(4H)-quinazolinyl)-N-[4-(1-pyrrolidinylsulfonyl)phenyl]propanamide::3-(4-oxo-3-quinazolinyl)-N-[4-(1-pyrrolidinylsulfonyl)phenyl]propanamide::3-(4-oxoquinazolin-3-yl)-N-(4-pyrrolidin-1-ylsulfonylphenyl)propanamide::MLS000051041::SMR000078850::cid_1096313 Mitogen-activated protein kinase 10 Homo sapiens 38190 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42811&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1096313 252623501 ZINC00818886 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79812 C(Nc1ncnc2n(ncc12)-c1ccccc1)c1ccco1 InChI=1S/C16H13N5O/c1-2-5-12(6-3-1)21-16-14(10-20-21)15(18-11-19-16)17-9-13-7-4-8-22-13/h1-8,10-11H,9H2,(H,17,18,19) RVWAKGRFWFNZQF-UHFFFAOYSA-N 42812 2-furfuryl-(1-phenylpyrazolo[3,4-d]pyrimidin-4-yl)amine::MLS000061251::N-(2-furanylmethyl)-1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine::N-(2-furylmethyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine::N-(furan-2-ylmethyl)-1-phenyl-pyrazolo[3,4-d]pyrimidin-4-amine::N-(furan-2-ylmethyl)-1-phenylpyrazolo[3,4-d]pyrimidin-4-amine::SMR000070120::cid_220776 Mitogen-activated protein kinase 10 Homo sapiens 60940 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42812&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 220776 252623502 ZINC03152718 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79813 CCOC(=O)N1CCN(CC1)C(=O)C1CCC(Cn2c(=S)[nH]c3ccccc3c2=O)CC1 InChI=1S/C23H30N4O4S/c1-2-31-23(30)26-13-11-25(12-14-26)20(28)17-9-7-16(8-10-17)15-27-21(29)18-5-3-4-6-19(18)24-22(27)32/h3-6,16-17H,2,7-15H2,1H3,(H,24,32) NGQCWZMNIAGKSH-UHFFFAOYSA-N 42813 4-[4-[(4-keto-2-thioxo-1H-quinazolin-3-yl)methyl]cyclohexanecarbonyl]piperazine-1-carboxylic acid ethyl ester::4-[oxo-[4-[(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)methyl]cyclohexyl]methyl]-1-piperazinecarboxylic acid ethyl ester::MLS000049602::SMR000076161::cid_2952870::ethyl 4-({4-[(4-oxo-2-thioxo-1,4-dihydro-3(2H)-quinazolinyl)methyl]cyclohexyl}carbonyl)-1-piperazinecarboxylate::ethyl 4-[4-[(4-oxidanylidene-2-sulfanylidene-1H-quinazolin-3-yl)methyl]cyclohexyl]carbonylpiperazine-1-carboxylate::ethyl 4-[4-[(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)methyl]cyclohexanecarbonyl]piperazine-1-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 3259 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42813&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2952870 252623503 ZINC04014284 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79814 CS(=O)(=O)N1CCN(CC1)c1ccccc1NC(=O)Cc1ccccc1 InChI=1S/C19H23N3O3S/c1-26(24,25)22-13-11-21(12-14-22)18-10-6-5-9-17(18)20-19(23)15-16-7-3-2-4-8-16/h2-10H,11-15H2,1H3,(H,20,23) SYEXKBHYZAGRCZ-UHFFFAOYSA-N 42814 MLS000100336::N-[2-(4-mesylpiperazino)phenyl]-2-phenyl-acetamide::N-[2-(4-methylsulfonyl-1-piperazinyl)phenyl]-2-phenylacetamide::N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]-2-phenyl-ethanamide::N-[2-(4-methylsulfonylpiperazin-1-yl)phenyl]-2-phenylacetamide::N-{2-[4-(methylsulfonyl)-1-piperazinyl]phenyl}-2-phenylacetamide::SMR000082630::cid_1018009 Mitogen-activated protein kinase 10 Homo sapiens 68850 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42814&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1018009 252623504 ZINC00680145 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79815 COC(=O)c1sccc1NC(=O)c1ccc(OC)cc1 InChI=1S/C14H13NO4S/c1-18-10-5-3-9(4-6-10)13(16)15-11-7-8-20-12(11)14(17)19-2/h3-8H,1-2H3,(H,15,16) IQHFVFGUPWQQCP-UHFFFAOYSA-N 42815 3-(p-anisoylamino)thiophene-2-carboxylic acid methyl ester::3-[[(4-methoxyphenyl)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester::MLS000063023::SMR000071802::cid_844198::methyl 3-[(4-methoxybenzoyl)amino]-2-thiophenecarboxylate::methyl 3-[(4-methoxybenzoyl)amino]thiophene-2-carboxylate::methyl 3-[(4-methoxyphenyl)carbonylamino]thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 26800 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42815&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 844198 252623505 ZINC00375431 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79816 CC1NC(=O)NC1CCCCCC(=O)NCCc1ccccc1 InChI=1S/C18H27N3O2/c1-14-16(21-18(23)20-14)10-6-3-7-11-17(22)19-13-12-15-8-4-2-5-9-15/h2,4-5,8-9,14,16H,3,6-7,10-13H2,1H3,(H,19,22)(H2,20,21,23) ZUWQXYDMMUZDNB-UHFFFAOYSA-N 42816 6-(2-keto-5-methyl-imidazolidin-4-yl)-N-phenethyl-hexanamide::6-(5-methyl-2-oxidanylidene-imidazolidin-4-yl)-N-(2-phenylethyl)hexanamide::6-(5-methyl-2-oxo-4-imidazolidinyl)-N-(2-phenylethyl)hexanamide::6-(5-methyl-2-oxoimidazolidin-4-yl)-N-(2-phenylethyl)hexanamide::MLS000052067::SMR000081349::cid_2974150 Mitogen-activated protein kinase 10 Homo sapiens 6263 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42816&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2974150 252623506 ZINC02876613 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79817 COc1ccc(Cl)cc1-c1nnc(S)o1 InChI=1S/C9H7ClN2O2S/c1-13-7-3-2-5(10)4-6(7)8-11-12-9(15)14-8/h2-4H,1H3,(H,12,15) FOBNNSSNVSMNMG-UHFFFAOYSA-N 42817 5-(5-chloranyl-2-methoxy-phenyl)-3H-1,3,4-oxadiazole-2-thione::5-(5-chloro-2-methoxy-phenyl)-3H-1,3,4-oxadiazole-2-thione::5-(5-chloro-2-methoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione::5-(5-chloro-2-methoxyphenyl)-3H-1,3,4-oxadiazole-2-thione::MLS000061371::SMR000070630::cid_701063 Mitogen-activated protein kinase 10 Homo sapiens 16160 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42817&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 701063 252623507 ZINC06492170 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79818 O=C(C1CCC(Cn2c(=S)[nH]c3ccccc3c2=O)CC1)N1CCN(CC1)c1ccccc1 InChI=1S/C26H30N4O2S/c31-24(29-16-14-28(15-17-29)21-6-2-1-3-7-21)20-12-10-19(11-13-20)18-30-25(32)22-8-4-5-9-23(22)27-26(30)33/h1-9,19-20H,10-18H2,(H,27,33) LOJWCKAJJWXFDG-UHFFFAOYSA-N 42818 3-({4-[(4-phenyl-1-piperazinyl)carbonyl]cyclohexyl}methyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone::3-[[4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl]methyl]-2-sulfanylidene-1H-quinazolin-4-one::3-[[4-(4-phenylpiperazine-1-carbonyl)cyclohexyl]methyl]-2-sulfanylidene-1H-quinazolin-4-one::3-[[4-(4-phenylpiperazine-1-carbonyl)cyclohexyl]methyl]-2-thioxo-1H-quinazolin-4-one::3-[[4-[oxo-(4-phenyl-1-piperazinyl)methyl]cyclohexyl]methyl]-2-sulfanylidene-1H-quinazolin-4-one::MLS000097399::SMR000076048::cid_2952511 Mitogen-activated protein kinase 10 Homo sapiens 929 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42818&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2952511 252623508 ZINC04014305 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79819 CCOC(=O)c1ccccc1NC(=O)COc1ccccc1 InChI=1S/C17H17NO4/c1-2-21-17(20)14-10-6-7-11-15(14)18-16(19)12-22-13-8-4-3-5-9-13/h3-11H,2,12H2,1H3,(H,18,19) MRWIAATXNSIRNK-UHFFFAOYSA-N 42819 2-[(1-oxo-2-phenoxyethyl)amino]benzoic acid ethyl ester::2-[(2-phenoxyacetyl)amino]benzoic acid ethyl ester::MLS000061492::SMR000070671::cid_874248::ethyl 2-(2-phenoxyethanoylamino)benzoate::ethyl 2-[(2-phenoxyacetyl)amino]benzoate::ethyl 2-[(phenoxyacetyl)amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 29460 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42819&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 874248 252623509 ZINC00442271 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79820 COC(=O)c1cccc(Cn2nnc3ccccc3c2=O)c1 InChI=1S/C16H13N3O3/c1-22-16(21)12-6-4-5-11(9-12)10-19-15(20)13-7-2-3-8-14(13)17-18-19/h2-9H,10H2,1H3 LMVXBYXBFZYUCA-UHFFFAOYSA-N 42820 3-[(4-keto-1,2,3-benzotriazin-3-yl)methyl]benzoic acid methyl ester::3-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]benzoic acid methyl ester::MLS000066258::SMR000079928::cid_1266769::methyl 3-[(4-oxidanylidene-1,2,3-benzotriazin-3-yl)methyl]benzoate::methyl 3-[(4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl]benzoate::methyl 3-[(4-oxo-1,2,3-benzotriazin-3-yl)methyl]benzoate Mitogen-activated protein kinase 10 Homo sapiens 78760 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42820&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1266769 252623510 ZINC01079665 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79821 CNC(=O)c1nc[nH]c1C(=O)Nc1cccc(OC)c1 InChI=1S/C13H14N4O3/c1-14-12(18)10-11(16-7-15-10)13(19)17-8-4-3-5-9(6-8)20-2/h3-7H,1-2H3,(H,14,18)(H,15,16)(H,17,19) PMLSUHAVDUOYFN-UHFFFAOYSA-N 42821 4-N-(3-methoxyphenyl)-5-N-methyl-1H-imidazole-4,5-dicarboxamide::MLS000099692::N-(3-methoxyphenyl)-N'-methyl-1H-imidazole-4,5-dicarboxamide::N4-(3-methoxyphenyl)-N5-methyl-1H-imidazole-4,5-dicarboxamide::N~4~-(3-methoxyphenyl)-N~5~-methyl-1H-imidazole-4,5-dicarboxamide::SMR000074586::cid_851156 Mitogen-activated protein kinase 10 Homo sapiens 50120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42821&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 851156 252623511 ZINC00385940 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79822 CCCCC(=O)Nc1ncc(Br)s1 InChI=1S/C8H11BrN2OS/c1-2-3-4-7(12)11-8-10-5-6(9)13-8/h5H,2-4H2,1H3,(H,10,11,12) HOCBGJXGIXFATC-UHFFFAOYSA-N 42822 MLS000066333::N-(5-bromanyl-1,3-thiazol-2-yl)pentanamide::N-(5-bromo-1,3-thiazol-2-yl)pentanamide::N-(5-bromo-2-thiazolyl)pentanamide::N-(5-bromothiazol-2-yl)valeramide::SMR000080773::cid_2225496 Mitogen-activated protein kinase 10 Homo sapiens 54860 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42822&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2225496 252623512 ZINC02872846 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79823 COC(=O)c1c(C)c(C)sc1NC(=O)Cc1cccs1 InChI=1S/C14H15NO3S2/c1-8-9(2)20-13(12(8)14(17)18-3)15-11(16)7-10-5-4-6-19-10/h4-6H,7H2,1-3H3,(H,15,16) BQUWADWFOWEFFF-UHFFFAOYSA-N 42823 4,5-dimethyl-2-[(1-oxo-2-thiophen-2-ylethyl)amino]-3-thiophenecarboxylic acid methyl ester::4,5-dimethyl-2-[[2-(2-thienyl)acetyl]amino]thiophene-3-carboxylic acid methyl ester::MLS000065768::SMR000080449::cid_1245885::methyl 4,5-dimethyl-2-(2-thiophen-2-ylethanoylamino)thiophene-3-carboxylate::methyl 4,5-dimethyl-2-[(2-thienylacetyl)amino]-3-thiophenecarboxylate::methyl 4,5-dimethyl-2-[(2-thiophen-2-ylacetyl)amino]thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 34820 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42823&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1245885 252623513 ZINC01054396 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79824 O=C(CCn1cnc2ccccc2c1=O)Nc1ccc(cc1)S(=O)(=O)N1CCCCC1 InChI=1S/C22H24N4O4S/c27-21(12-15-25-16-23-20-7-3-2-6-19(20)22(25)28)24-17-8-10-18(11-9-17)31(29,30)26-13-4-1-5-14-26/h2-3,6-11,16H,1,4-5,12-15H2,(H,24,27) YRYNHFCJTNSYHV-UHFFFAOYSA-N 42824 3-(4-ketoquinazolin-3-yl)-N-(4-piperidinosulfonylphenyl)propionamide::3-(4-oxidanylidenequinazolin-3-yl)-N-(4-piperidin-1-ylsulfonylphenyl)propanamide::3-(4-oxo-3(4H)-quinazolinyl)-N-[4-(1-piperidinylsulfonyl)phenyl]propanamide::3-(4-oxo-3-quinazolinyl)-N-[4-(1-piperidinylsulfonyl)phenyl]propanamide::3-(4-oxoquinazolin-3-yl)-N-(4-piperidin-1-ylsulfonylphenyl)propanamide::MLS000097296::SMR000075856::cid_1291315 Mitogen-activated protein kinase 10 Homo sapiens 38420 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42824&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1291315 252623514 ZINC01113240 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79825 Clc1ccc(cc1Cl)C1=NOC(C1)C(=O)Nc1cccnc1 InChI=1S/C15H11Cl2N3O2/c16-11-4-3-9(6-12(11)17)13-7-14(22-20-13)15(21)19-10-2-1-5-18-8-10/h1-6,8,14H,7H2,(H,19,21) CRUALRMPHFCKNP-UHFFFAOYSA-N 42825 3-(3,4-dichlorophenyl)-N-(3-pyridinyl)-4,5-dihydroisoxazole-5-carboxamide::3-(3,4-dichlorophenyl)-N-(3-pyridyl)-2-isoxazoline-5-carboxamide::3-(3,4-dichlorophenyl)-N-3-pyridinyl-4,5-dihydro-5-isoxazolecarboxamide::3-(3,4-dichlorophenyl)-N-pyridin-3-yl-4,5-dihydro-1,2-oxazole-5-carboxamide::MLS000064498::SMR000078267::cid_2962200 Mitogen-activated protein kinase 10 Homo sapiens 22900 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42825&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2962200 252623515 ZINC04058278 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79826 c1ccc2c(c1)[nH]c1nc3ccccc3nc21 InChI=1S/C14H9N3/c1-2-6-10-9(5-1)13-14(16-10)17-12-8-4-3-7-11(12)15-13/h1-8H,(H,16,17) LCKIWLDOHFUYDV-UHFFFAOYSA-N 42826 6H-indolo[2,3-b]quinoxaline::6H-indolo[3,2-b]quinoxaline::MLS000053030::SMR000068993::cid_5356192 Mitogen-activated protein kinase 10 Homo sapiens 13870 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42826&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5356192 252623516 ZINC01300693 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79827 COC(=O)c1ccccc1NC(=O)NCc1ccc(OC)c(OC)c1 InChI=1S/C18H20N2O5/c1-23-15-9-8-12(10-16(15)24-2)11-19-18(22)20-14-7-5-4-6-13(14)17(21)25-3/h4-10H,11H2,1-3H3,(H2,19,20,22) MMBFWEASPKRKSZ-UHFFFAOYSA-N 42827 2-(veratrylcarbamoylamino)benzoic acid methyl ester::2-[[[(3,4-dimethoxyphenyl)methylamino]-oxomethyl]amino]benzoic acid methyl ester::MLS000064005::SMR000076985::cid_971348::methyl 2-({[(3,4-dimethoxybenzyl)amino]carbonyl}amino)benzoate::methyl 2-[(3,4-dimethoxyphenyl)methylcarbamoylamino]benzoate Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42827&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 971348 252623517 ZINC00611148 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79828 CCOC(=O)c1ccccc1NC(=O)CN(c1ccccc1)S(=O)(=O)N(C)C InChI=1S/C19H23N3O5S/c1-4-27-19(24)16-12-8-9-13-17(16)20-18(23)14-22(28(25,26)21(2)3)15-10-6-5-7-11-15/h5-13H,4,14H2,1-3H3,(H,20,23) MPJPJLPEGLZYKV-UHFFFAOYSA-N 42828 2-[[2-[N-(dimethylsulfamoyl)anilino]-1-oxoethyl]amino]benzoic acid ethyl ester::2-[[2-[N-(dimethylsulfamoyl)anilino]acetyl]amino]benzoic acid ethyl ester::MLS000050797::SMR000078410::cid_1294200::ethyl 2-({N-[(dimethylamino)sulfonyl]-N-phenylglycyl}amino)benzoate::ethyl 2-[2-[dimethylsulfamoyl(phenyl)amino]ethanoylamino]benzoate::ethyl 2-[[2-[N-(dimethylsulfamoyl)anilino]acetyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 49310 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42828&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1294200 252623518 ZINC01116672 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79829 CCN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1 InChI=1S/C17H19BrClN3O2/c1-2-21-8-10-22(11-9-21)16-12(19)4-3-5-13(16)20-17(23)14-6-7-15(18)24-14/h3-7H,2,8-11H2,1H3,(H,20,23) PRHPUPZVWXCHHI-UHFFFAOYSA-N 32455 cid_979869::piperazine amide, 1 Mitogen-activated protein kinase 10 Homo sapiens 1505 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32455&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 979869 85256322 ZINC00624282 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79830 CCOC(=O)c1cnc2ccc(Cl)cc2c1N1CCN(C)CC1 InChI=1S/C17H20ClN3O2/c1-3-23-17(22)14-11-19-15-5-4-12(18)10-13(15)16(14)21-8-6-20(2)7-9-21/h4-5,10-11H,3,6-9H2,1-2H3 FWSNZBITEXDMTP-UHFFFAOYSA-N 42829 6-chloro-4-(4-methyl-1-piperazinyl)-3-quinolinecarboxylic acid ethyl ester::6-chloro-4-(4-methylpiperazino)quinoline-3-carboxylic acid ethyl ester::MLS000099296::SMR000073573::cid_725467::ethyl 6-chloranyl-4-(4-methylpiperazin-1-yl)quinoline-3-carboxylate::ethyl 6-chloro-4-(4-methyl-1-piperazinyl)-3-quinolinecarboxylate::ethyl 6-chloro-4-(4-methylpiperazin-1-yl)quinoline-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 25890 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42829&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 725467 252623519 ZINC19792957 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79831 Cc1nc(CSc2nc3n[nH]cc3c(=O)n2-c2ccccc2)cs1 InChI=1S/C16H13N5OS2/c1-10-18-11(8-23-10)9-24-16-19-14-13(7-17-20-14)15(22)21(16)12-5-3-2-4-6-12/h2-8H,9H2,1H3,(H,17,20) PJYACDWZSICXPQ-UHFFFAOYSA-N 42830 6-[(2-methyl-1,3-thiazol-4-yl)methylsulfanyl]-5-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-one::6-[(2-methyl-4-thiazolyl)methylthio]-5-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-one::6-[(2-methylthiazol-4-yl)methylthio]-5-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-one::6-{[(2-methyl-1,3-thiazol-4-yl)methyl]thio}-5-phenyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one::MLS000049487::SMR000075496::cid_1288597 Mitogen-activated protein kinase 10 Homo sapiens 809 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42830&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1288597 252623520 ZINC08667254 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79832 O=c1n2CCCCNc2nc2ccccc12 InChI=1S/C12H13N3O/c16-11-9-5-1-2-6-10(9)14-12-13-7-3-4-8-15(11)12/h1-2,5-6H,3-4,7-8H2,(H,13,14) VXLQEGSDBDDJQH-UHFFFAOYSA-N 40086 2,3,4,5-tetrahydro[1,3]diazepino[2,1-b]quinazolin-7(1H)-one::3,4,5,12-tetrahydro-2H-[1,3]diazepino[2,1-b]quinazolin-7-one::MLS000066787::SMR000070256::cid_5403383 Mitogen-activated protein kinase 10 Homo sapiens 39490 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40086&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5403383 252620916 ZINC06492090 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79833 O=C(C1CCC(Cn2c(=O)[nH]c3ccccc3c2=O)CC1)N1CCN(CC1)c1ccccc1 InChI=1S/C26H30N4O3/c31-24(29-16-14-28(15-17-29)21-6-2-1-3-7-21)20-12-10-19(11-13-20)18-30-25(32)22-8-4-5-9-23(22)27-26(30)33/h1-9,19-20H,10-18H2,(H,27,33) BPEZFHQODUPVMF-UHFFFAOYSA-N 42831 3-[[4-(4-phenylpiperazin-1-yl)carbonylcyclohexyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-(4-phenylpiperazine-1-carbonyl)cyclohexyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-(4-phenylpiperazine-1-carbonyl)cyclohexyl]methyl]-1H-quinazoline-2,4-quinone::3-[[4-[oxo-(4-phenyl-1-piperazinyl)methyl]cyclohexyl]methyl]-1H-quinazoline-2,4-dione::MLS000120005::SMR000096922::cid_4907320 Mitogen-activated protein kinase 10 Homo sapiens 502 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42831&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 4907320 252623521 ZINC08971179 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79834 COC(=O)c1ccccc1NC(=O)CSc1nc(N)cc(N)n1 InChI=1S/C14H15N5O3S/c1-22-13(21)8-4-2-3-5-9(8)17-12(20)7-23-14-18-10(15)6-11(16)19-14/h2-6H,7H2,1H3,(H,17,20)(H4,15,16,18,19) MAOXUGRAIRXBQM-UHFFFAOYSA-N 42832 2-[[2-[(4,6-diamino-2-pyrimidinyl)thio]-1-oxoethyl]amino]benzoic acid methyl ester::2-[[2-[(4,6-diaminopyrimidin-2-yl)thio]acetyl]amino]benzoic acid methyl ester::MLS000114795::SMR000092100::cid_2168982::methyl 2-[2-[4,6-bis(azanyl)pyrimidin-2-yl]sulfanylethanoylamino]benzoate::methyl 2-[[2-(4,6-diaminopyrimidin-2-yl)sulfanylacetyl]amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 11710 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42832&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2168982 252623522 ZINC02769991 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79835 Cc1cc(NC(=O)C2CC(=NO2)c2ccc(F)cc2)no1 InChI=1S/C14H12FN3O3/c1-8-6-13(18-20-8)16-14(19)12-7-11(17-21-12)9-2-4-10(15)5-3-9/h2-6,12H,7H2,1H3,(H,16,18,19) ZXNONIZUNZMICX-UHFFFAOYSA-N 42833 3-(4-fluorophenyl)-N-(5-methyl-1,2-oxazol-3-yl)-4,5-dihydro-1,2-oxazole-5-carboxamide::3-(4-fluorophenyl)-N-(5-methyl-3-isoxazolyl)-4,5-dihydroisoxazole-5-carboxamide::3-(4-fluorophenyl)-N-(5-methylisoxazol-3-yl)-2-isoxazoline-5-carboxamide::MLS000118503::SMR000095444::cid_5307528 Mitogen-activated protein kinase 10 Homo sapiens 28450 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42833&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5307528 252623523 ZINC05029745 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79836 Cn1c(cc2c1c1ccccc1n(C)c2=O)C(=O)N1CCN(Cc2ccc3OCOc3c2)CC1 InChI=1S/C26H26N4O4/c1-27-21(14-19-24(27)18-5-3-4-6-20(18)28(2)25(19)31)26(32)30-11-9-29(10-12-30)15-17-7-8-22-23(13-17)34-16-33-22/h3-8,13-14H,9-12,15-16H2,1-2H3 NGDPXEHUKKXCFE-UHFFFAOYSA-N 42834 1,5-dimethyl-2-(4-piperonylpiperazine-1-carbonyl)pyrrolo[3,2-c]quinolin-4-one::2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]carbonyl-1,5-dimethyl-pyrrolo[3,2-c]quinolin-4-one::2-[4-(1,3-benzodioxol-5-ylmethyl)piperazine-1-carbonyl]-1,5-dimethylpyrrolo[3,2-c]quinolin-4-one::2-[[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-oxomethyl]-1,5-dimethyl-4-pyrrolo[3,2-c]quinolinone::MLS000118103::SMR000095051::cid_5307856 Mitogen-activated protein kinase 10 Homo sapiens 72610 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42834&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5307856 252623524 ZINC20286270 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79837 CCn1c(SCC(=O)Nc2ccc(Cl)cc2)nnc1C1CC1 InChI=1S/C15H17ClN4OS/c1-2-20-14(10-3-4-10)18-19-15(20)22-9-13(21)17-12-7-5-11(16)6-8-12/h5-8,10H,2-4,9H2,1H3,(H,17,21) XNXFQSNXIBIXNP-UHFFFAOYSA-N 38187 MLS000115911::N-(4-chlorophenyl)-2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]acetamide::N-(4-chlorophenyl)-2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)sulfanyl]ethanamide::N-(4-chlorophenyl)-2-[(5-cyclopropyl-4-ethyl-1,2,4-triazol-3-yl)thio]acetamide::SMR000092915::cid_713065 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=38187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=38187&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 713065 252619134 ZINC00106589 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79838 Cc1ccc2oc(=O)c3cnn(CC(=O)N4CCN(CC4)c4ccccn4)c3c2c1 InChI=1S/C22H21N5O3/c1-15-5-6-18-16(12-15)21-17(22(29)30-18)13-24-27(21)14-20(28)26-10-8-25(9-11-26)19-4-2-3-7-23-19/h2-7,12-13H,8-11,14H2,1H3 JMHFCSDYGXDBMP-UHFFFAOYSA-N 42835 1-[2-keto-2-[4-(2-pyridyl)piperazino]ethyl]-8-methyl-chromeno[4,3-c]pyrazol-4-one::8-methyl-1-[2-oxidanylidene-2-(4-pyridin-2-ylpiperazin-1-yl)ethyl]chromeno[4,3-c]pyrazol-4-one::8-methyl-1-[2-oxo-2-(4-pyridin-2-ylpiperazin-1-yl)ethyl]chromeno[4,3-c]pyrazol-4-one::8-methyl-1-[2-oxo-2-[4-(2-pyridinyl)-1-piperazinyl]ethyl]-4-[1]benzopyrano[4,3-c]pyrazolone::MLS000118345::SMR000095287::cid_5308368 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42835&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5308368 252623525 ZINC04961728 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79839 CCc1cc(=O)oc2cc(C)cc(O)c12 InChI=1S/C12H12O3/c1-3-8-6-11(14)15-10-5-7(2)4-9(13)12(8)10/h4-6,13H,3H2,1-2H3 BGKWMMAJZNSSGJ-UHFFFAOYSA-N 42836 4-ethyl-5-hydroxy-7-methyl-1-benzopyran-2-one::4-ethyl-5-hydroxy-7-methyl-coumarin::4-ethyl-5-hydroxy-7-methylchromen-2-one::4-ethyl-7-methyl-5-oxidanyl-chromen-2-one::MLS000114221::SMR000091644::cid_5308898 Mitogen-activated protein kinase 10 Homo sapiens 32500 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42836&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5308898 252623526 ZINC06519560 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79840 COCCCNC(=O)c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1 InChI=1S/C20H21N3O4/c1-27-12-4-11-21-18(24)15-9-7-14(8-10-15)13-23-19(25)16-5-2-3-6-17(16)22-20(23)26/h2-3,5-10H,4,11-13H2,1H3,(H,21,24)(H,22,26) IONFHWANFSEYKJ-UHFFFAOYSA-N 42837 4-[(2,4-diketo-1H-quinazolin-3-yl)methyl]-N-(3-methoxypropyl)benzamide::4-[(2,4-dioxo-1H-quinazolin-3-yl)methyl]-N-(3-methoxypropyl)benzamide::4-[[2,4-bis(oxidanylidene)-1H-quinazolin-3-yl]methyl]-N-(3-methoxypropyl)benzamide::MLS000119998::SMR000096915::cid_5144290 Mitogen-activated protein kinase 10 Homo sapiens 6203 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42837&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5144290 252623527 ZINC02952230 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79841 CCOc1ccc(NC(=O)CN2C(=O)C3CCCN3C2=O)cc1 InChI=1S/C16H19N3O4/c1-2-23-12-7-5-11(6-8-12)17-14(20)10-19-15(21)13-4-3-9-18(13)16(19)22/h5-8,13H,2-4,9-10H2,1H3,(H,17,20) RXACAGTWPFPNKS-UHFFFAOYSA-N 42838 2-(1,3-diketo-5,6,7,7a-tetrahydropyrrol[1,2-c]imidazol-2-yl)-N-p-phenetyl-acetamide::2-(1,3-dioxo-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-2-yl)-N-(4-ethoxyphenyl)acetamide::2-[1,3-bis(oxidanylidene)-5,6,7,7a-tetrahydropyrrolo[1,2-c]imidazol-2-yl]-N-(4-ethoxyphenyl)ethanamide::MLS000115978::SMR000092977::cid_4270974 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42838&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 4270974 252623528 ZINC04601019 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79842 O=C(N1CCN(CC1)c1ccccn1)c1ccc(Cn2c(=O)[nH]c3ccccc3c2=O)cc1 InChI=1S/C25H23N5O3/c31-23(29-15-13-28(14-16-29)22-7-3-4-12-26-22)19-10-8-18(9-11-19)17-30-24(32)20-5-1-2-6-21(20)27-25(30)33/h1-12H,13-17H2,(H,27,33) IPPMWRHWVWZESI-UHFFFAOYSA-N 42839 3-[4-[4-(2-pyridyl)piperazine-1-carbonyl]benzyl]-1H-quinazoline-2,4-quinone::3-[[4-(4-pyridin-2-ylpiperazin-1-yl)carbonylphenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-(4-pyridin-2-ylpiperazine-1-carbonyl)phenyl]methyl]-1H-quinazoline-2,4-dione::3-[[4-[oxo-[4-(2-pyridinyl)-1-piperazinyl]methyl]phenyl]methyl]-1H-quinazoline-2,4-dione::MLS000119999::SMR000096916::cid_5216019 Mitogen-activated protein kinase 10 Homo sapiens 10510 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42839&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5216019 252623529 ZINC02952257 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79843 CC(=O)Oc1ccc(cc1)C(=O)Nc1nccs1 InChI=1S/C12H10N2O3S/c1-8(15)17-10-4-2-9(3-5-10)11(16)14-12-13-6-7-18-12/h2-7H,1H3,(H,13,14,16) SSCLNLFSZHICJE-UHFFFAOYSA-N 42840 MLS000114158::SMR000091598::[4-(1,3-thiazol-2-ylcarbamoyl)phenyl] acetate::[4-(1,3-thiazol-2-ylcarbamoyl)phenyl] ethanoate::acetic acid [4-(thiazol-2-ylcarbamoyl)phenyl] ester::acetic acid [4-[oxo-(2-thiazolylamino)methyl]phenyl] ester::cid_791564 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42840&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 791564 252623530 ZINC00292583 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79844 COc1ccc(CNC(=O)c2cnn3c(cc(C)nc23)C(F)F)cc1OC InChI=1S/C18H18F2N4O3/c1-10-6-13(16(19)20)24-17(23-10)12(9-22-24)18(25)21-8-11-4-5-14(26-2)15(7-11)27-3/h4-7,9,16H,8H2,1-3H3,(H,21,25) NIJGMEXJBBRTIX-UHFFFAOYSA-N 42841 7-(difluoromethyl)-5-methyl-N-veratryl-pyrazolo[1,5-a]pyrimidine-3-carboxamide::7-(difluoromethyl)-N-[(3,4-dimethoxyphenyl)methyl]-5-methyl-3-pyrazolo[1,5-a]pyrimidinecarboxamide::7-(difluoromethyl)-N-[(3,4-dimethoxyphenyl)methyl]-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide::7-[bis(fluoranyl)methyl]-N-[(3,4-dimethoxyphenyl)methyl]-5-methyl-pyrazolo[1,5-a]pyrimidine-3-carboxamide::MLS000115221::SMR000092389::cid_1093977 Mitogen-activated protein kinase 10 Homo sapiens >31040 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42841&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1093977 252623531 ZINC00815302 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79845 CNC(=O)c1ccsc1NC(=O)c1ccccc1 InChI=1S/C13H12N2O2S/c1-14-12(17)10-7-8-18-13(10)15-11(16)9-5-3-2-4-6-9/h2-8H,1H3,(H,14,17)(H,15,16) JPNMQJFTAFUPFW-UHFFFAOYSA-N 42842 2-benzamido-N-methyl-3-thiophenecarboxamide::2-benzamido-N-methyl-thiophene-3-carboxamide::2-benzamido-N-methylthiophene-3-carboxamide::MLS000103262::SMR000018672::cid_5309978 Mitogen-activated protein kinase 10 Homo sapiens 5460 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42842&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5309978 252623532 ZINC04275790 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79846 COC(=O)c1ccsc1NC(=O)C1COc2ccccc2O1 InChI=1S/C15H13NO5S/c1-19-15(18)9-6-7-22-14(9)16-13(17)12-8-20-10-4-2-3-5-11(10)21-12/h2-7,12H,8H2,1H3,(H,16,17) LKKPXTMYIDATGA-UHFFFAOYSA-N 42843 2-(2,3-dihydro-1,4-benzodioxin-3-carbonylamino)thiophene-3-carboxylic acid methyl ester::2-[[2,3-dihydro-1,4-benzodioxin-3-yl(oxo)methyl]amino]-3-thiophenecarboxylic acid methyl ester::MLS000103246::SMR000018657::cid_5310017::methyl 2-(2,3-dihydro-1,4-benzodioxin-3-ylcarbonylamino)thiophene-3-carboxylate::methyl 2-(2,3-dihydro-1,4-benzodioxine-3-carbonylamino)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 26970 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42843&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5310017 252623533 ZINC04275688 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79847 COc1ccc(cc1OC)C(=O)NCc1nc2ccccc2[nH]1 InChI=1S/C17H17N3O3/c1-22-14-8-7-11(9-15(14)23-2)17(21)18-10-16-19-12-5-3-4-6-13(12)20-16/h3-9H,10H2,1-2H3,(H,18,21)(H,19,20) JANQZRWEDYHYJC-UHFFFAOYSA-N 42844 MLS000101367::N-(1H-benzimidazol-2-ylmethyl)-3,4-dimethoxy-benzamide::N-(1H-benzimidazol-2-ylmethyl)-3,4-dimethoxybenzamide::SMR000016063::cid_751094 Mitogen-activated protein kinase 10 Homo sapiens 23150 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42844&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 751094 252623534 ZINC00200678 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79848 O=C(Nc1ccc(cc1)-c1nc2cccnc2s1)c1ccco1 InChI=1S/C17H11N3O2S/c21-15(14-4-2-10-22-14)19-12-7-5-11(6-8-12)16-20-13-3-1-9-18-17(13)23-16/h1-10H,(H,19,21) LAUHYJXIRLADBR-UHFFFAOYSA-N 42845 MLS000102787::N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)-2-furamide::N-[4-(2-thiazolo[5,4-b]pyridinyl)phenyl]-2-furancarboxamide::N-[4-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]furan-2-carboxamide::SMR000016908::cid_4336986 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42845&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 4336986 252623535 ZINC02961306 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79849 COC(=O)c1ccsc1NC(=O)C1=COCCO1 InChI=1S/C11H11NO5S/c1-15-11(14)7-2-5-18-10(7)12-9(13)8-6-16-3-4-17-8/h2,5-6H,3-4H2,1H3,(H,12,13) IMATXVPNABHDDN-UHFFFAOYSA-N 42846 2-(2,3-dihydro-p-dioxin-5-carbonylamino)thiophene-3-carboxylic acid methyl ester::2-[[2,3-dihydro-1,4-dioxin-5-yl(oxo)methyl]amino]-3-thiophenecarboxylic acid methyl ester::MLS000103248::SMR000018659::cid_5310086::methyl 2-(2,3-dihydro-1,4-dioxin-5-ylcarbonylamino)thiophene-3-carboxylate::methyl 2-(2,3-dihydro-1,4-dioxine-5-carbonylamino)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 9148 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42846&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5310086 252623536 ZINC04275692 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79850 CCCC(=O)Nc1cc(C)c2c(n1)c1ccccc1oc2=O InChI=1S/C17H16N2O3/c1-3-6-14(20)18-13-9-10(2)15-16(19-13)11-7-4-5-8-12(11)22-17(15)21/h4-5,7-9H,3,6H2,1-2H3,(H,18,19,20) IRQVBIRRLBCVGC-UHFFFAOYSA-N 42847 MLS000101702::N-(4-methyl-5-oxidanylidene-chromeno[4,3-b]pyridin-2-yl)butanamide::N-(4-methyl-5-oxo-2-[1]benzopyrano[4,3-b]pyridinyl)butanamide::N-(4-methyl-5-oxochromeno[4,3-b]pyridin-2-yl)butanamide::N-(5-keto-4-methyl-chromeno[4,3-b]pyridin-2-yl)butyramide::SMR000016279::cid_4459714 Mitogen-activated protein kinase 10 Homo sapiens 54420 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42847&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 4459714 252623537 ZINC00428468 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79851 NC(=O)c1ccsc1NC(=O)c1ccco1 InChI=1S/C10H8N2O3S/c11-8(13)6-3-5-16-10(6)12-9(14)7-2-1-4-15-7/h1-5H,(H2,11,13)(H,12,14) HEIVIJJEKZUFAZ-UHFFFAOYSA-N 42848 MLS000103255::N-(3-aminocarbonylthiophen-2-yl)furan-2-carboxamide::N-(3-carbamoyl-2-thienyl)-2-furamide::N-(3-carbamoyl-2-thiophenyl)-2-furancarboxamide::N-(3-carbamoylthiophen-2-yl)furan-2-carboxamide::SMR000018665::cid_2971371 Mitogen-activated protein kinase 10 Homo sapiens 10530 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42848&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2971371 252623538 ZINC04275735 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79852 COc1cccc(c1)C(=O)Nc1c(oc2ccccc12)C(N)=O InChI=1S/C17H14N2O4/c1-22-11-6-4-5-10(9-11)17(21)19-14-12-7-2-3-8-13(12)23-15(14)16(18)20/h2-9H,1H3,(H2,18,20)(H,19,21) ARLNYGOQDMCXLP-UHFFFAOYSA-N 42849 3-(m-anisoylamino)coumarilamide::3-[(3-methoxybenzoyl)amino]-1-benzofuran-2-carboxamide::3-[(3-methoxyphenyl)carbonylamino]-1-benzofuran-2-carboxamide::3-[[(3-methoxyphenyl)-oxomethyl]amino]-2-benzofurancarboxamide::MLS000102896::SMR000018561::cid_4053250 Mitogen-activated protein kinase 10 Homo sapiens 32060 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42849&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 4053250 252623539 ZINC04135036 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79853 NC(=O)c1ccsc1NC(=O)c1ccc(cc1)S(=O)(=O)N1CCCCC1 InChI=1S/C17H19N3O4S2/c18-15(21)14-8-11-25-17(14)19-16(22)12-4-6-13(7-5-12)26(23,24)20-9-2-1-3-10-20/h4-8,11H,1-3,9-10H2,(H2,18,21)(H,19,22) QCMGFWVZIVDQKD-UHFFFAOYSA-N 42850 2-[(4-piperidin-1-ylsulfonylbenzoyl)amino]thiophene-3-carboxamide::2-[(4-piperidin-1-ylsulfonylphenyl)carbonylamino]thiophene-3-carboxamide::2-[(4-piperidinosulfonylbenzoyl)amino]thiophene-3-carboxamide::2-[[oxo-[4-(1-piperidinylsulfonyl)phenyl]methyl]amino]-3-thiophenecarboxamide::MLS000103254::SMR000018664::cid_2501747 Mitogen-activated protein kinase 10 Homo sapiens 8827 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42850&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2501747 252623540 ZINC03383469 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79854 NC(=O)c1ccsc1NC(=O)C1CCCCC1 InChI=1S/C12H16N2O2S/c13-10(15)9-6-7-17-12(9)14-11(16)8-4-2-1-3-5-8/h6-8H,1-5H2,(H2,13,15)(H,14,16) QOPUTUZZAFIRJE-UHFFFAOYSA-N 42851 2-(cyclohexanecarbonylamino)thiophene-3-carboxamide::2-(cyclohexylcarbonylamino)thiophene-3-carboxamide::2-[[cyclohexyl(oxo)methyl]amino]-3-thiophenecarboxamide::MLS000103257::SMR000018667::cid_5310374 Mitogen-activated protein kinase 10 Homo sapiens 25910 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42851&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5310374 252623541 ZINC04275740 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79855 NC(=O)c1ccsc1NC(=O)C1CC1 InChI=1S/C9H10N2O2S/c10-7(12)6-3-4-14-9(6)11-8(13)5-1-2-5/h3-5H,1-2H2,(H2,10,12)(H,11,13) RUSGOABQFZHUSY-UHFFFAOYSA-N 42852 2-(cyclopropanecarbonylamino)thiophene-3-carboxamide::2-(cyclopropylcarbonylamino)thiophene-3-carboxamide::2-[[cyclopropyl(oxo)methyl]amino]-3-thiophenecarboxamide::MLS000103259::SMR000018669::cid_3321377 Mitogen-activated protein kinase 10 Homo sapiens 32790 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42852&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3321377 252623542 ZINC04275756 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79856 NC(=O)c1oc2ccccc2c1NC(=O)c1ccco1 InChI=1S/C14H10N2O4/c15-13(17)12-11(8-4-1-2-5-9(8)20-12)16-14(18)10-6-3-7-19-10/h1-7H,(H2,15,17)(H,16,18) VRCCQQNVDLIJGO-UHFFFAOYSA-N 42853 3-(2-furoylamino)coumarilamide::3-(furan-2-carbonylamino)-1-benzofuran-2-carboxamide::3-(furan-2-ylcarbonylamino)-1-benzofuran-2-carboxamide::3-[[2-furanyl(oxo)methyl]amino]-2-benzofurancarboxamide::MLS000102839::SMR000018564::cid_3349764 Mitogen-activated protein kinase 10 Homo sapiens 9896 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42853&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3349764 252623543 ZINC00240269 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79857 CCn1c(nc2ccccc12)C(C)NC(C)=O InChI=1S/C13H17N3O/c1-4-16-12-8-6-5-7-11(12)15-13(16)9(2)14-10(3)17/h5-9H,4H2,1-3H3,(H,14,17) QXCMDFKDUFYDJH-UHFFFAOYSA-N 42854 MLS000101370::N-[1-(1-ethyl-2-benzimidazolyl)ethyl]acetamide::N-[1-(1-ethylbenzimidazol-2-yl)ethyl]acetamide::N-[1-(1-ethylbenzimidazol-2-yl)ethyl]ethanamide::SMR000016065::cid_2975259 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42854&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2975259 252623544 ZINC00200724 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79858 NC(=O)c1oc2ccccc2c1NC(=O)c1ccc(F)cc1 InChI=1S/C16H11FN2O3/c17-10-7-5-9(6-8-10)16(21)19-13-11-3-1-2-4-12(11)22-14(13)15(18)20/h1-8H,(H2,18,20)(H,19,21) SUKPTNGJUYNFIG-UHFFFAOYSA-N 42855 3-[(4-fluorobenzoyl)amino]-1-benzofuran-2-carboxamide::3-[(4-fluorobenzoyl)amino]coumarilamide::3-[(4-fluorophenyl)carbonylamino]-1-benzofuran-2-carboxamide::3-[[(4-fluorophenyl)-oxomethyl]amino]-2-benzofurancarboxamide::MLS000102893::SMR000018558::cid_3273996 Mitogen-activated protein kinase 10 Homo sapiens 23900 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42855&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3273996 252623545 ZINC03893422 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79859 NC(=O)c1ccsc1NC(=O)c1cccs1 InChI=1S/C10H8N2O2S2/c11-8(13)6-3-5-16-10(6)12-9(14)7-2-1-4-15-7/h1-5H,(H2,11,13)(H,12,14) OEIOSAFYCBYSPX-UHFFFAOYSA-N 42856 2-(2-thenoylamino)thiophene-3-carboxamide::2-(thiophen-2-ylcarbonylamino)thiophene-3-carboxamide::2-(thiophene-2-carbonylamino)thiophene-3-carboxamide::2-[[oxo(thiophen-2-yl)methyl]amino]-3-thiophenecarboxamide::MLS000103253::SMR000018663::cid_2971411 Mitogen-activated protein kinase 10 Homo sapiens 2619 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42856&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2971411 252623546 ZINC04275726 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79860 O=C(NCc1nc2ccccc2[nH]1)c1cccs1 InChI=1S/C13H11N3OS/c17-13(11-6-3-7-18-11)14-8-12-15-9-4-1-2-5-10(9)16-12/h1-7H,8H2,(H,14,17)(H,15,16) HEPYZVOFXYSVGR-UHFFFAOYSA-N 42857 MLS000101368::N-(1H-benzimidazol-2-ylmethyl)-2-thiophenecarboxamide::N-(1H-benzimidazol-2-ylmethyl)thiophene-2-carboxamide::SMR000017761::cid_751095 Mitogen-activated protein kinase 10 Homo sapiens 43020 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42857&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 751095 252623547 ZINC00200680 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79861 Cc1nc(SCCC(O)=O)c2ccccc2n1 InChI=1S/C12H12N2O2S/c1-8-13-10-5-3-2-4-9(10)12(14-8)17-7-6-11(15)16/h2-5H,6-7H2,1H3,(H,15,16) BWOVZKBKWYSBAR-UHFFFAOYSA-N 42858 3-(2-methylquinazolin-4-yl)sulfanylpropanoic acid::3-[(2-methyl-4-quinazolinyl)thio]propanoic acid::3-[(2-methylquinazolin-4-yl)thio]propionic acid::MLS000112624::SMR000108535::cid_588806 Mitogen-activated protein kinase 10 Homo sapiens 5959 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42858&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 588806 252623548 ZINC00037804 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79862 COC(=O)c1sccc1NC(=O)c1ccc(Br)o1 InChI=1S/C11H8BrNO4S/c1-16-11(15)9-6(4-5-18-9)13-10(14)7-2-3-8(12)17-7/h2-5H,1H3,(H,13,14) AAVMFXCTHZZIFE-UHFFFAOYSA-N 42859 3-[(5-bromo-2-furoyl)amino]thiophene-2-carboxylic acid methyl ester::3-[[(5-bromo-2-furanyl)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl ester::MLS000113955::SMR000109845::cid_2167035::methyl 3-[(5-bromanylfuran-2-yl)carbonylamino]thiophene-2-carboxylate::methyl 3-[(5-bromofuran-2-carbonyl)amino]thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 19960 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42859&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2167035 252623549 ZINC02757009 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79863 COC(=O)c1c(NC(=O)CN2CCOCC2)scc1-c1cccs1 InChI=1S/C16H18N2O4S2/c1-21-16(20)14-11(12-3-2-8-23-12)10-24-15(14)17-13(19)9-18-4-6-22-7-5-18/h2-3,8,10H,4-7,9H2,1H3,(H,17,19) JQZXVCZYFOHPQK-UHFFFAOYSA-N 42860 2-[(2-morpholinoacetyl)amino]-4-(2-thienyl)thiophene-3-carboxylic acid methyl ester::2-[[2-(4-morpholinyl)-1-oxoethyl]amino]-4-thiophen-2-yl-3-thiophenecarboxylic acid methyl ester::MLS000113617::SMR000109513::cid_1189893::methyl 2-(2-morpholin-4-ylethanoylamino)-4-thiophen-2-yl-thiophene-3-carboxylate::methyl 2-[(2-morpholin-4-ylacetyl)amino]-4-thiophen-2-ylthiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 55660 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42860&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1189893 252623550 ZINC19902842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79864 Cc1cn(cn1)S(=O)(=O)c1ccc(Br)c2ccccc12 InChI=1S/C14H11BrN2O2S/c1-10-8-17(9-16-10)20(18,19)14-7-6-13(15)11-4-2-3-5-12(11)14/h2-9H,1H3 YUYJSGJEULUJRL-UHFFFAOYSA-N 42861 1-(4-bromanylnaphthalen-1-yl)sulfonyl-4-methyl-imidazole::1-(4-bromonaphthalen-1-yl)sulfonyl-4-methylimidazole::1-[(4-bromo-1-naphthalenyl)sulfonyl]-4-methylimidazole::1-[(4-bromo-1-naphthyl)sulfonyl]-4-methyl-imidazole::MLS000107756::SMR000103720::cid_1355435 Mitogen-activated protein kinase 10 Homo sapiens 15530 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42861&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1355435 252623551 ZINC01195733 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79865 C1COc2cc3c(onc3cc2O1)-c1ccccc1 InChI=1S/C15H11NO3/c1-2-4-10(5-3-1)15-11-8-13-14(18-7-6-17-13)9-12(11)16-19-15/h1-5,8-9H,6-7H2 YOYOMTNVZRVGIO-UHFFFAOYSA-N 42862 3-phenyl-6,7-dihydro-[1,4]dioxino[2,3-f][2,1]benzoxazole::MLS000113340::SMR000109241::cid_695625 Mitogen-activated protein kinase 10 Homo sapiens 50060 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42862&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 695625 252623552 ZINC00070166 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79866 Brc1ccc2nc3CCCCc3n2c1 InChI=1S/C11H11BrN2/c12-8-5-6-11-13-9-3-1-2-4-10(9)14(11)7-8/h5-7H,1-4H2 XLNQAGVAQAWLHM-UHFFFAOYSA-N 42863 2-bromanyl-6,7,8,9-tetrahydropyrido[1,2-a]benzimidazole::2-bromo-6,7,8,9-tetrahydropyrido[1,2-a]benzimidazole::MLS000104784::SMR000054717::cid_717369 Mitogen-activated protein kinase 10 Homo sapiens 13930 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42863&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 717369 252623553 ZINC00115904 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79867 COc1cc(ccc1O)C1NC(=O)N=C(C)C1C(=O)OC1CCCC(C)C1 InChI=1S/C20H26N2O5/c1-11-5-4-6-14(9-11)27-19(24)17-12(2)21-20(25)22-18(17)13-7-8-15(23)16(10-13)26-3/h7-8,10-11,14,17-18,23H,4-6,9H2,1-3H3,(H,22,25) GEYUDGOBFPLGGT-UHFFFAOYSA-N 42864 (3-methylcyclohexyl) 4-(3-methoxy-4-oxidanyl-phenyl)-6-methyl-2-oxidanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate::(3-methylcyclohexyl) 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate::4-(4-hydroxy-3-methoxy-phenyl)-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (3-methylcyclohexyl) ester::4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (3-methylcyclohexyl) ester::MLS000106951::SMR000111326::cid_2848468 Mitogen-activated protein kinase 10 Homo sapiens 39440 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42864&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896547 252623554 ZINC04066246 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79868 CC1=NC(=O)NC(C1C(=O)OC1CCCCCCC1)c1ccc(O)cc1 InChI=1S/C20H26N2O4/c1-13-17(19(24)26-16-7-5-3-2-4-6-8-16)18(22-20(25)21-13)14-9-11-15(23)12-10-14/h9-12,16-18,23H,2-8H2,1H3,(H,22,25) MRFXDWPEGGXWFA-UHFFFAOYSA-N 42865 4-(4-hydroxyphenyl)-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid cyclooctyl ester::4-(4-hydroxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid cyclooctyl ester::MLS000107451::SMR000111819::cid_2855653::cyclooctyl 4-(4-hydroxyphenyl)-6-methyl-2-oxidanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate::cyclooctyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 41870 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42865&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896548 252623555 ZINC01190333 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79869 CCOC(=O)CCC(NC(=O)c1ccc(NCN2C(=O)c3ccccc3C2=O)cc1)C(=O)OCC InChI=1S/C25H27N3O7/c1-3-34-21(29)14-13-20(25(33)35-4-2)27-22(30)16-9-11-17(12-10-16)26-15-28-23(31)18-7-5-6-8-19(18)24(28)32/h5-12,20,26H,3-4,13-15H2,1-2H3,(H,27,30) XTPJBWUTBKKSGH-UHFFFAOYSA-N 42866 2-[[4-(phthalimidomethylamino)benzoyl]amino]glutaric acid diethyl ester::2-[[[4-[(1,3-dioxo-2-isoindolyl)methylamino]phenyl]-oxomethyl]amino]pentanedioic acid diethyl ester::MLS000109860::SMR000105795::cid_2885377::diethyl 2-[[4-[(1,3-dioxoisoindol-2-yl)methylamino]benzoyl]amino]pentanedioate::diethyl 2-[[4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methylamino]phenyl]carbonylamino]pentanedioate Mitogen-activated protein kinase 10 Homo sapiens 13130 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42866&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2885377 252623556 ZINC06549644 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79870 COC(=O)c1ccccc1NC(=O)COc1ccccc1 InChI=1S/C16H15NO4/c1-20-16(19)13-9-5-6-10-14(13)17-15(18)11-21-12-7-3-2-4-8-12/h2-10H,11H2,1H3,(H,17,18) DJNDEMVSWNRGSC-UHFFFAOYSA-N 42867 2-[(1-oxo-2-phenoxyethyl)amino]benzoic acid methyl ester::2-[(2-phenoxyacetyl)amino]benzoic acid methyl ester::MLS000106819::SMR000111195::cid_809705::methyl 2-(2-phenoxyethanoylamino)benzoate::methyl 2-[(2-phenoxyacetyl)amino]benzoate Mitogen-activated protein kinase 10 Homo sapiens 28630 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42867&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 809705 252623557 ZINC00320955 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79871 CN1C=CC(C=C1)=C1C(=O)c2ccccc2C1=O InChI=1S/C15H11NO2/c1-16-8-6-10(7-9-16)13-14(17)11-4-2-3-5-12(11)15(13)18/h2-9H,1H3 FDEWLYYIZFPGCV-UHFFFAOYSA-N 42868 2-(1-methyl-4-pyridinylidene)indene-1,3-dione::2-(1-methyl-4-pyridylidene)indane-1,3-quinone::2-(1-methylpyridin-4-ylidene)indene-1,3-dione::MLS000105672::SMR000102650::cid_793927 Mitogen-activated protein kinase 10 Homo sapiens 28540 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42868&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 793927 252623558 ZINC00296416 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79872 CC(NCc1cccnc1)=C1C(=O)c2ccccc2C1=O InChI=1S/C17H14N2O2/c1-11(19-10-12-5-4-8-18-9-12)15-16(20)13-6-2-3-7-14(13)17(15)21/h2-9,19H,10H2,1H3 PHDAHWZSPANQBT-UHFFFAOYSA-N 42869 2-[1-(3-pyridinylmethylamino)ethylidene]indene-1,3-dione::2-[1-(3-pyridylmethylamino)ethylidene]indane-1,3-quinone::2-[1-(pyridin-3-ylmethylamino)ethylidene]indene-1,3-dione::MLS000104951::SMR000054881::cid_2063368 Mitogen-activated protein kinase 10 Homo sapiens 20010 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42869&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2063368 252623559 ZINC05605462 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79873 CCN1C=CC(C=C1)=C1C(=O)c2ccccc2C1=O InChI=1S/C16H13NO2/c1-2-17-9-7-11(8-10-17)14-15(18)12-5-3-4-6-13(12)16(14)19/h3-10H,2H2,1H3 XHNFURAQPBTAFS-UHFFFAOYSA-N 39062 2-(1-ethyl-4-pyridinylidene)indene-1,3-dione::2-(1-ethyl-4-pyridylidene)indane-1,3-quinone::2-(1-ethylpyridin-4-ylidene)indene-1,3-dione::MLS000105604::SMR000102582::cid_206388 Mitogen-activated protein kinase 10 Homo sapiens 43530 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39062&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 206388 252619961 ZINC00295579 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79874 Cc1cc(C)n(n1)-c1cc(Nc2ccc(C)cc2)ncn1 InChI=1S/C16H17N5/c1-11-4-6-14(7-5-11)19-15-9-16(18-10-17-15)21-13(3)8-12(2)20-21/h4-10H,1-3H3,(H,17,18,19) JFEKPMKGHSALHL-UHFFFAOYSA-N 42870 6-(3,5-dimethyl-1-pyrazolyl)-N-(4-methylphenyl)-4-pyrimidinamine::6-(3,5-dimethylpyrazol-1-yl)-N-(4-methylphenyl)pyrimidin-4-amine::MLS000105198::SMR000055127::[6-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]-(p-tolyl)amine::cid_791111 Mitogen-activated protein kinase 10 Homo sapiens 13440 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42870&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 791111 252623560 ZINC00291891 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79875 Clc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1 InChI=1S/C13H10ClN3/c14-8-2-4-11-10(5-8)9-3-1-7-6-15-17-12(7)13(9)16-11/h2,4-6,16H,1,3H2,(H,15,17) PLOLFTFTXWLIRO-UHFFFAOYSA-N 42871 7-chloranyl-1,2,4,5-tetrahydropyrazolo[3,4-a]carbazole::7-chloro-1,2,4,5-tetrahydropyrazolo[3,4-a]carbazole::MLS000108710::SMR000104663::cid_5310693 Mitogen-activated protein kinase 10 Homo sapiens 2164 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42871&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5310693 252623561 ZINC13131072 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79876 O=C1C(=CNCc2cccnc2)C(=O)c2ccccc12 InChI=1S/C16H12N2O2/c19-15-12-5-1-2-6-13(12)16(20)14(15)10-18-9-11-4-3-7-17-8-11/h1-8,10,18H,9H2 ZZHOEXQCYUBVJI-UHFFFAOYSA-N 42872 2-[(3-pyridinylmethylamino)methylidene]indene-1,3-dione::2-[(3-pyridylmethylamino)methylene]indane-1,3-quinone::2-[(pyridin-3-ylmethylamino)methylidene]indene-1,3-dione::MLS000109236::SMR000105181::cid_873976 Mitogen-activated protein kinase 10 Homo sapiens 32050 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42872&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 873976 252623562 ZINC06530991 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79877 Cc1sc(NC(=O)c2cccs2)c(C(N)=O)c1C InChI=1S/C12H12N2O2S2/c1-6-7(2)18-12(9(6)10(13)15)14-11(16)8-4-3-5-17-8/h3-5H,1-2H3,(H2,13,15)(H,14,16) OTIUGBVMROZGTK-UHFFFAOYSA-N 34547 4,5-dimethyl-2-(2-thenoylamino)thiophene-3-carboxamide::4,5-dimethyl-2-(thiophen-2-ylcarbonylamino)thiophene-3-carboxamide::4,5-dimethyl-2-(thiophene-2-carbonylamino)thiophene-3-carboxamide::4,5-dimethyl-2-[[oxo(thiophen-2-yl)methyl]amino]-3-thiophenecarboxamide::MLS000107266::SMR000111638::cid_673517 Mitogen-activated protein kinase 10 Homo sapiens 30810 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=34547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=34547&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 673517 252617208 ZINC00035583 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79878 Cc1cc(C)n(n1)-c1cc(Nc2ccc(C)cc2C)ncn1 InChI=1S/C17H19N5/c1-11-5-6-15(12(2)7-11)20-16-9-17(19-10-18-16)22-14(4)8-13(3)21-22/h5-10H,1-4H3,(H,18,19,20) WGWLAMPEILQKFT-UHFFFAOYSA-N 42873 (2,4-dimethylphenyl)-[6-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-yl]amine::MLS000105199::N-(2,4-dimethylphenyl)-6-(3,5-dimethyl-1-pyrazolyl)-4-pyrimidinamine::N-(2,4-dimethylphenyl)-6-(3,5-dimethylpyrazol-1-yl)pyrimidin-4-amine::SMR000055128::cid_791112 Mitogen-activated protein kinase 10 Homo sapiens 17680 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42873&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 791112 252623563 ZINC00291892 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79879 Cc1cccc(N=CC2C(=O)Nc3ccccc23)n1 InChI=1S/C15H13N3O/c1-10-5-4-8-14(17-10)16-9-12-11-6-2-3-7-13(11)18-15(12)19/h2-9,12H,1H3,(H,18,19) LHCGQMRIDVMVRU-UHFFFAOYSA-N 42874 (3Z)-3-[[(6-methyl-2-pyridinyl)amino]methylidene]-1H-indol-2-one::(3Z)-3-[[(6-methyl-2-pyridyl)amino]methylene]oxindole::(3Z)-3-[[(6-methylpyridin-2-yl)amino]methylidene]-1H-indol-2-one::MLS000107951::SMR000103915::cid_5310757 Mitogen-activated protein kinase 10 Homo sapiens 41670 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42874&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896549 252623564 ZINC05687825 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79880 O=C1Nc2ccccc2C1C=Nc1ccc2OCOc2c1 InChI=1S/C16H12N2O3/c19-16-12(11-3-1-2-4-13(11)18-16)8-17-10-5-6-14-15(7-10)21-9-20-14/h1-8,12H,9H2,(H,18,19) KKYCJXAOPKEOMS-UHFFFAOYSA-N 42875 (3Z)-3-[(1,3-benzodioxol-5-ylamino)methylene]oxindole::(3Z)-3-[(1,3-benzodioxol-5-ylamino)methylidene]-1H-indol-2-one::MLS000107781::SMR000103745::cid_5310766 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42875&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91438593 252623565 ZINC06553078 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79881 CC1(C)Cc2c(CO1)c(nc(SCC(=O)c1ccccc1)c2C#N)N1CCOCC1 InChI=1S/C23H25N3O3S/c1-23(2)12-17-18(13-24)22(30-15-20(27)16-6-4-3-5-7-16)25-21(19(17)14-29-23)26-8-10-28-11-9-26/h3-7H,8-12,14-15H2,1-2H3 GURONSBEPSPNLT-UHFFFAOYSA-N 42876 3,3-dimethyl-8-(4-morpholinyl)-6-(phenacylthio)-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile::3,3-dimethyl-8-morpholin-4-yl-6-phenacylsulfanyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile::3,3-dimethyl-8-morpholino-6-(phenacylthio)-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile::MLS000109302::SMR000105246::cid_1350038 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42876&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1350038 252623566 ZINC19774150 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79882 O=NC1c2ccccc2-c2c1cccc2C(=O)N1CCCCC1 InChI=1S/C19H18N2O2/c22-19(21-11-4-1-5-12-21)16-10-6-9-15-17(16)13-7-2-3-8-14(13)18(15)20-23/h2-3,6-10,18H,1,4-5,11-12H2 JHPGICCRHQMNKO-UHFFFAOYSA-N 42877 (9-hydroximinofluoren-4-yl)-piperidino-methanone::(9-hydroxyimino-4-fluorenyl)-(1-piperidinyl)methanone::(9-hydroxyiminofluoren-4-yl)-piperidin-1-yl-methanone::(9-hydroxyiminofluoren-4-yl)-piperidin-1-ylmethanone::MLS000111782::SMR000107701::cid_5310796 Mitogen-activated protein kinase 10 Homo sapiens 40680 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42877&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91158043 252623567 ZINC18008239 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79883 CCCN1C=CC(C=C1)=C1C(=O)c2ccccc2C1=O InChI=1S/C17H15NO2/c1-2-9-18-10-7-12(8-11-18)15-16(19)13-5-3-4-6-14(13)17(15)20/h3-8,10-11H,2,9H2,1H3 KRJAEYDFBGVIJB-UHFFFAOYSA-N 39072 2-(1-propyl-4-pyridinylidene)indene-1,3-dione::2-(1-propyl-4-pyridylidene)indane-1,3-quinone::2-(1-propylpyridin-4-ylidene)indene-1,3-dione::MLS000105679::SMR000102657::cid_793991 Mitogen-activated protein kinase 10 Homo sapiens 9841 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=39072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=39072&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 793991 252619971 ZINC00296529 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79884 COc1cccc2c(O)c(C\C=C(\C)Cl)c(C)nc12 InChI=1S/C15H16ClNO2/c1-9(16)7-8-11-10(2)17-14-12(15(11)18)5-4-6-13(14)19-3/h4-7H,8H2,1-3H3,(H,17,18)/b9-7- HZEDDZHFSQFBGP-CLFYSBASSA-N 42878 3-[(Z)-3-chloranylbut-2-enyl]-8-methoxy-2-methyl-1H-quinolin-4-one::3-[(Z)-3-chlorobut-2-enyl]-8-methoxy-2-methyl-1H-quinolin-4-one::3-[(Z)-3-chlorobut-2-enyl]-8-methoxy-2-methyl-4-quinolone::MLS000108957::SMR000104905::cid_760847 Mitogen-activated protein kinase 10 Homo sapiens 75010 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42878&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 760847 252623568 ZINC02349909 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79885 O=C1C(C(=O)c2ccccc12)c1ccncc1 InChI=1S/C14H9NO2/c16-13-10-3-1-2-4-11(10)14(17)12(13)9-5-7-15-8-6-9/h1-8,12H XSPDDUQLHWGPSP-UHFFFAOYSA-N 42659 2-(1H-pyridin-4-ylidene)indane-1,3-quinone::2-(1H-pyridin-4-ylidene)indene-1,3-dione::2-(4-pyridyl)indane-1,3-quinone::MLS000039587::SMR000038130::cid_5389994 Mitogen-activated protein kinase 10 Homo sapiens 18010 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42659&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 694901 252623351 ZINC00156742 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79886 COc1cc(ccc1O)C1NC(=O)N=C(C)C1C(=O)OCc1ccccc1 InChI=1S/C20H20N2O5/c1-12-17(19(24)27-11-13-6-4-3-5-7-13)18(22-20(25)21-12)14-8-9-15(23)16(10-14)26-2/h3-10,17-18,23H,11H2,1-2H3,(H,22,25) IVEOSZPCRBACFH-UHFFFAOYSA-N 42880 (phenylmethyl) 4-(3-methoxy-4-oxidanyl-phenyl)-6-methyl-2-oxidanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate::4-(4-hydroxy-3-methoxy-phenyl)-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid benzyl ester::4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (phenylmethyl) ester::MLS000107460::SMR000015536::benzyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate::cid_2855847 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42880&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896550 252623569 ZINC00812896 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79887 COc1ccc(COC(=O)C2C(NC(=O)N=C2C)c2ccc(O)c(OC)c2)cc1 InChI=1S/C21H22N2O6/c1-12-18(20(25)29-11-13-4-7-15(27-2)8-5-13)19(23-21(26)22-12)14-6-9-16(24)17(10-14)28-3/h4-10,18-19,24H,11H2,1-3H3,(H,23,26) JUVFMQWJTXLNII-UHFFFAOYSA-N 42881 (4-methoxyphenyl)methyl 4-(3-methoxy-4-oxidanyl-phenyl)-6-methyl-2-oxidanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate::(4-methoxyphenyl)methyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate::4-(4-hydroxy-3-methoxy-phenyl)-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid p-anisyl ester::4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid (4-methoxyphenyl)methyl ester::MLS000107428::SMR000111797::cid_2855196 Mitogen-activated protein kinase 10 Homo sapiens 33820 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42881&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896551 252623570 ZINC00716224 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79888 COc1ccc(OC)c(c1)C(=O)c1coc2ccc(O)cc12 InChI=1S/C17H14O5/c1-20-11-4-6-15(21-2)13(8-11)17(19)14-9-22-16-5-3-10(18)7-12(14)16/h3-9,18H,1-2H3 ZZXSSXYHBWCWGF-UHFFFAOYSA-N 42882 (2,5-dimethoxyphenyl)-(5-hydroxy-1-benzofuran-3-yl)methanone::(2,5-dimethoxyphenyl)-(5-hydroxy-3-benzofuranyl)methanone::(2,5-dimethoxyphenyl)-(5-hydroxybenzofuran-3-yl)methanone::(2,5-dimethoxyphenyl)-(5-oxidanyl-1-benzofuran-3-yl)methanone::MLS000105566::SMR000102447::cid_626866 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42882&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 626866 252623571 ZINC00036645 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79889 CN(C)C=NC(=O)C(C#N)C1=Nc2ccccc2CC1 InChI=1S/C15H16N4O/c1-19(2)10-17-15(20)12(9-16)14-8-7-11-5-3-4-6-13(11)18-14/h3-6,10,12H,7-8H2,1-2H3 HOMCKSXTLASKOD-UHFFFAOYSA-N 40997 (2E)-2-cyano-2-(3,4-dihydro-1H-quinolin-2-ylidene)-N-(dimethylaminomethylene)acetamide::(2E)-2-cyano-2-(3,4-dihydro-1H-quinolin-2-ylidene)-N-(dimethylaminomethylidene)acetamide::(2E)-2-cyano-2-(3,4-dihydro-1H-quinolin-2-ylidene)-N-(dimethylaminomethylidene)ethanamide::MLS000109572::SMR000105512::cid_5310919 Mitogen-activated protein kinase 10 Homo sapiens >93120 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=40997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=40997&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91896498 252621776 ZINC18067442 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 79890 O=c1n(Cc2cccnc2)c(=S)[nH]c2ccccc12 InChI=1S/C14H11N3OS/c18-13-11-5-1-2-6-12(11)16-14(19)17(13)9-10-4-3-7-15-8-10/h1-8H,9H2,(H,16,19) PZLVJPPOFNKHFH-UHFFFAOYSA-N 42883 3-(3-pyridinylmethyl)-2-sulfanylidene-1H-quinazolin-4-one::3-(3-pyridylmethyl)-2-thioxo-1H-quinazolin-4-one::3-(pyridin-3-ylmethyl)-2-sulfanylidene-1H-quinazolin-4-one::MLS000112139::SMR000108055::cid_710792 Mitogen-activated protein kinase 10 Homo sapiens 23730 PubChem 10.7270/Q2KK996K aid1284 PubChem, PC The Scripps Research Institute Molecular Screening Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42883&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 710792 252623572 ZINC03888606 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171960 Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H IKMDFBPHZNJCSN-UHFFFAOYSA-N 15236 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one::3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one::CHEMBL164::Cannabiscetin::Myricetin::Myricetin (20)::Myricetin (Myr)::cid_5281672 Mitogen-activated protein kinase 10 Homo sapiens 2.24e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15236&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search MYC 3HBF,7DPP,2IOD,5YUN,6M88,5HXC,7B3E,1E90,4GQR,7ELW,5XI1,6TTC,3C1T,2O63,7E49 5281672 46515543 18152 CHEMBL164 DB02375 C10107 ZINC03874317 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171961 Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H XHEFDIBZLJXQHF-UHFFFAOYSA-N 7457 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromone;dihydrate::CHEMBL31574::Fisetin (14)::Fisetin, 15::fisetin Mitogen-activated protein kinase 10 Homo sapiens 2.6e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7457&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search FSE 4RLT,3P0H,1XO2 5281614 11108248 42567 CHEMBL31574 DB07795 5182 C10041 ZINC00039111 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171962 Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H REFJWTPEDVJJIY-UHFFFAOYSA-N 7460 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate::CHEMBL50::Quercetin::Quercetin (10)::Quercetin (21)::Quercetin (Qur)::US11021454, Compound Quercetin::US9180183, Quercetin::med.21724, Compound 4 Mitogen-activated protein kinase 10 Homo sapiens 2.31e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7460&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search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itogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171963 COc1cc(O)c2c(c1)oc(-c1ccc(OC)c(O)c1)c(O)c2=O InChI=1S/C17H14O7/c1-22-9-6-11(19)14-13(7-9)24-17(16(21)15(14)20)8-3-4-12(23-2)10(18)5-8/h3-7,18-19,21H,1-2H3 BWORNNDZQGOKBY-UHFFFAOYSA-N 50240614 3,5-Dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-methoxy-chromen-4-one::4',7-dimethylquercetin::CHEMBL75589::Kaempferol-7,4'-dimethylether::OMBUINE::quercetin-7,4'-dimethyl ether Mitogen-activated protein kinase 10 Homo sapiens 5.54e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240614&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5320287 104098379 67493 CHEMBL75589 ZINC01645590 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171964 Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H YXOLAZRVSSWPPT-UHFFFAOYSA-N 26658 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one::2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone::2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one::2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one::CHEMBL28626::MLS000069618::Morin (19)::Morin (5)::Morin (Mor)::SMR000058259::cid_5281670::morin Mitogen-activated protein kinase 10 Homo sapiens 2.68e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26658&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search MRI 5AUY,8A0P,7E4B,6AE3,6TT8 5281670 57298370 75092 CHEMBL28626 411 C10105 ZINC03881558 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171965 COc1c(O)cc2oc(-c3ccc(O)c(O)c3)c(O)c(=O)c2c1O InChI=1S/C16H12O8/c1-23-16-9(19)5-10-11(13(16)21)12(20)14(22)15(24-10)6-2-3-7(17)8(18)4-6/h2-5,17-19,21-22H,1H3 JMIFIYIEXODVTO-UHFFFAOYSA-N 84976 Patuletin Mitogen-activated protein kinase 10 Homo sapiens 6.09e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84976&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5281678 136351076 75164 C10118 ZINC06483403 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171966 COc1c(O)cc2oc(-c3ccc(O)cc3)c(O)c(=O)c2c1O InChI=1S/C16H12O7/c1-22-16-9(18)6-10-11(13(16)20)12(19)14(21)15(23-10)7-2-4-8(17)5-3-7/h2-6,17-18,20-21H,1H3 OGQSUSFDBWGFFJ-UHFFFAOYSA-N 84977 6-methoxy kaempferol Mitogen-activated protein kinase 10 Homo sapiens 2.24e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84977&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5377945 136351077 ZINC02583586 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171967 Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H IYRMWMYZSQPJKC-UHFFFAOYSA-N 7462 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::3,5,7-trihydroxy-2-(4-hydroxyphenyl)-chromen-4-one::CHEMBL150::Kaempferol (18)::Kaempferol (Kmp)::cid_5280863::kaempferol Mitogen-activated protein kinase 10 Homo sapiens 1.91e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7462&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search KMP 5AV2,4DET,5AUX,6M8B,5AV3,4REL,3QWH,1H1M,7VEJ,2C1Z 5280863 11108253 28499 CHEMBL150 DB01852 C05903 ZINC03869768 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171968 COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3 IZQSVPBOUDKVDZ-UHFFFAOYSA-N 23409 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one::CHEMBL379064::Isorhamnetin::Isorhamnetin (17) Mitogen-activated protein kinase 10 Homo sapiens 6.3e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23409&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search IRH 7CBA,6M8C 5281654 50091673 6052 CHEMBL379064 C10084 ZINC00517261 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171969 COc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O InChI=1S/C16H12O6/c1-21-10-4-2-8(3-5-10)16-15(20)14(19)13-11(18)6-9(17)7-12(13)22-16/h2-7,17-18,20H,1H3 SQFSKOYWJBQGKQ-UHFFFAOYSA-N 50084978 3,5,7-trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one::CHEMBL40919::Kaempferide::Kaempferol 4'-methyl ether Mitogen-activated protein kinase 10 Homo sapiens 5.25e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50084978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50084978&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5281666 103984461 6099 CHEMBL40919 C10098 ZINC06411540 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171970 COc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(OC)c2=O InChI=1S/C17H14O7/c1-22-9-6-12(20)14-13(7-9)24-16(17(23-2)15(14)21)8-3-4-10(18)11(19)5-8/h3-7,18-20H,1-2H3 LUJAXSNNYBCFEE-UHFFFAOYSA-N 50240897 2-(3,4-dihydroxyphenyl)-5-hydroxy-3,7-dimethoxy-4H-chromen-4-one::3',4',5-trihydroxy-3,7-dimethoxyflavone::CHEMBL164861::Quercetin-3,7-dimethylether Mitogen-activated protein kinase 10 Homo sapiens 7.7e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50240897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50240897&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5280417 104098492 18010 CHEMBL164861 C01265 ZINC05732362 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171971 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C21H20O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-18,21-24,26-29H,1H3/t7-,15-,17+,18+,21-/m0/s1 XHIUPRGKXRAZCR-HQBVPOQASA-N 84978 Quercitrin::cid_5280459 Mitogen-activated protein kinase 10 Homo sapiens 2.02e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84978&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5280459 136351078 17558 C02757 ZINC04175638 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171972 OC[C@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2/t13-,15-,17+,18-,21+/m1/s1 DPFYPHSPTUZJJT-QSOFNFLRSA-N 50241354 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one::3,3',4',5,7-pentahydroxyflavone-3-beta-O-glucoside::3-glucoside isoquercitrin::CHEMBL250450::Hyperin::Hyperoside::NSC-407304::Quercetin 3-O-beta-D-glucoside::Quercetin-3-O-beta-D-galactopyranoside::Quercetin-3-glucoside::cid_5280804::cid_5378597::hirsutrin::hydroside::isoquercetin::isoquercetrin::quercetin -3-O-beta-D-galactopyranoside::quercetin 3-O-beta-D-galactopyranoside::quercetin 3-O-beta-D-glucopyranoside::quercetin 3-O-galactoside::quercetin 3-O-glucopyranoside::quercetin 3-O-glucoside::quercetin-3-galactoside Mitogen-activated protein kinase 10 Homo sapiens 2.17e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241354&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5280804 104098737 68352 CHEMBL250450 C03400 ZINC04096845 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171973 OCC1OC(O)C(Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)C(O)C1O InChI=1S/C21H20O12/c22-6-13-15(27)17(29)20(21(30)32-13)33-19-16(28)14-11(26)4-8(23)5-12(14)31-18(19)7-1-2-9(24)10(25)3-7/h1-5,13,15,17,20-25,27-30H,6H2 JDCKEYDYTNBCCS-UHFFFAOYSA-N 84979 Isoquercitrin Mitogen-activated protein kinase 10 Homo sapiens 2.17e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84979&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57339948 136351079 ZINC86865007 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171974 Oc1cc(O)c2CC(OC(=O)c3ccc(O)c(O)c3O)C(Oc2c1)c1cc(O)c(O)c(O)c1 InChI=1S/C22H18O11/c23-9-5-13(25)11-7-17(33-22(31)10-1-2-12(24)20(30)18(10)28)21(32-16(11)6-9)8-3-14(26)19(29)15(27)4-8/h1-6,17,21,23-30H,7H2 ZJONSYFOVDKINV-UHFFFAOYSA-N 84980 (-) EPIGALLOCATECHIN GALLATE Mitogen-activated protein kinase 10 Homo sapiens 2.35e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84980&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44134699 136351080 ZINC21992201 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171975 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1cc(O)c(O)c(O)c1 InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15+/m0/s1 XMOCLSLCDHWDHP-SWLSCSKDSA-N 50135165 (+)-gallocatechin::(2R,3S)-2-(3,4,5-Trihydroxy-phenyl)-chroman-3,5,7-triol::CHEMBL125743 Mitogen-activated protein kinase 10 Homo sapiens 5.3e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50135165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50135165&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 65084 104025592 71224 CHEMBL125743 C12127 ZINC03870338 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171976 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c1ccc(O)c(O)c1 InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 23417 α-CA inhibitor, 4::(-)-Epicatechin::(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol::Epicatechin::L-Epicatechin::cid_72276 Mitogen-activated protein kinase 10 Homo sapiens 8.95e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23417&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 28E 6AWV,6AWT,6AX0,4MA6 72276 50091681 90 C09727 ZINC00119988 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171977 Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1 InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H IQPNAANSBPBGFQ-UHFFFAOYSA-N 7459 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one::CHEMBL151::Luteolin (27)::Luteolin (4)::acs.jmedchem.1c00409_ST.600::cid_5280445::luteolin::med.21724, Compound 3 Mitogen-activated protein kinase 10 Homo sapiens 2.3e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7459&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search LU2 4HKN,4QYA,6YA5,4DGN,5AUU,6M8A,4DEW,3SZ1,7D3B,7EBV,5II2,5NDF,4QXV 5280445 11108250 15864 CHEMBL151 5215 C01514 ZINC18185774 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171978 Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1 InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H KZNIFHPLKGYRTM-UHFFFAOYSA-N 7458 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one::5,7-dihydroxy-2-(4-hydroxyphenyl)-chromen-4-one::Apigenin::Apigenin (2)::Apigenin (3)::Apigenin (7)::Apigenin, 13::CHEMBL28::Naringenin, 18::US10278929, Apigenin::US11337935, Compound Apigenin::acs.jmedchem.1c00409_ST.789::cid_5280443::jm5b01461, Compound 90 Mitogen-activated protein kinase 10 Homo sapiens 2.2e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7458&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search AGI 4HKK,4DGM,5I2H,5AUV,4DER,7D3A,3AMY,4WO0,3CF9,5UQT 5280443 11108249 18388 CHEMBL28 DB07352 4136 C01477 ZINC03871576 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171979 COc1ccc(cc1O)-c1cc(=O)c2c(O)cc(O)cc2o1 InChI=1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3 MBNGWHIJMBWFHU-UHFFFAOYSA-N 23414 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one::Diosmetin::Diosmetin (25) Mitogen-activated protein kinase 10 Homo sapiens 2.86e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23414&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search J8D 6M8D 5281612 50091678 4630 C10038 ZINC05733652 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171980 Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1 InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H RTIXKCRFFJGDFG-UHFFFAOYSA-N 7461 5,7-dihydroxy-2-phenyl-4H-chromen-4-one::5,7-dihydroxy-2-phenyl-chromen-4-one::5,7-dihydroxyflavone::CHEMBL117::chrysin::cid_5281607 Mitogen-activated protein kinase 10 Homo sapiens 1.18e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7461&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57D 4DES,3EBO,7D38 5281607 11108252 75095 CHEMBL117 C10028 ZINC03872070 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171981 COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1 InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3 DANYIYRPLHHOCZ-UHFFFAOYSA-N 23415 5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one::Acacetin::CHEMBL243664 Mitogen-activated protein kinase 10 Homo sapiens 5.78e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23415&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5280442 50091679 15335 CHEMBL243664 C01470 ZINC03871358 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171982 OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(O)c(O)c1 InChI=1S/C21H20O11/c22-6-14-17(28)18(29)19(30)21(32-14)16-11(26)4-10(25)15-12(27)5-13(31-20(15)16)7-1-2-8(23)9(24)3-7/h1-5,14,17-19,21-26,28-30H,6H2/t14-,17-,18+,19-,21+/m1/s1 PLAPMLGJVGLZOV-VPRICQMDSA-N 84982 Luteolin 8-C-glucoside Mitogen-activated protein kinase 10 Homo sapiens 3.82e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84982&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search USE 7NUG,7NUH 5281675 136351082 7781 C10114 ZINC04098560 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171983 OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O InChI=1S/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21-/m1/s1 PEFNSGRTCBGNAN-QNDFHXLGSA-N 50241242 2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside::7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(3,4-dihydroxyphenyl)-4H-chromen-4-one::7-Glucoluteolin::7-Glucosylluteolin::CHEMBL233929::Cinaroside::Cynaroside::Luteolin 7-O-β-D-glucoside (13)::Luteolin 7-O-glucopyranoside::Luteolin 7-O-glucoside::Luteolin 7-glucoside::Luteolin 7-monoglucoside::Luteolin-7-glucoside::Luteoloside::cid_5280637::luteolin 7-O-beta-D-glucoside Mitogen-activated protein kinase 10 Homo sapiens 2.45e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241242&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5280637 104098671 27994 CHEMBL233929 C03400 ZINC04096258 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171984 COc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(OC)c1 InChI=1S/C17H14O6/c1-21-10-6-12(19)17-13(20)8-14(23-16(17)7-10)9-3-4-11(18)15(5-9)22-2/h3-8,18-19H,1-2H3 ROCUOVBWAWAQFD-UHFFFAOYSA-N 84983 Velutin Mitogen-activated protein kinase 10 Homo sapiens 7.8e+3 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84983&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5464381 136351083 ZINC05732373 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171985 COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)cc1 InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3 IHFBPDAQLQOCBX-UHFFFAOYSA-N 50049395 5,7,4'-Trihydroxy-6-methoxyflavone::5,7-Dihydroxy-2-(4-hydroxy-phenyl)-6-methoxy-chromen-4-one::5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one::6-methoxy apigenin::6-methoxyapigenin::CHEMBL293776::Hispidulin::NSC-122415::TCMDC-123942::cid_5281628::dinatin Mitogen-activated protein kinase 10 Homo sapiens 3.48e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049395&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search HUL 4XH6 5281628 103979749 75902 CHEMBL293776 C10058 ZINC05732241 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171986 COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1 InChI=1S/C16H12O7/c1-22-16-11(20)6-13-14(15(16)21)10(19)5-12(23-13)7-2-3-8(17)9(18)4-7/h2-6,17-18,20-21H,1H3 FHHSEFRSDKWJKJ-UHFFFAOYSA-N 23412 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one::6-Methoxyluteolin::CHEMBL172350::Eupafolin::cid_5317284 Mitogen-activated protein kinase 10 Homo sapiens 1.59e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23412&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5317284 50091676 CHEMBL172350 ZINC05998557 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171987 COc1cc(ccc1O)-c1cc(=O)c2c(O)c(OC)c(O)cc2o1 InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3 GLAAQZFBFGEBPS-UHFFFAOYSA-N 84984 Jaceosidin Mitogen-activated protein kinase 10 Homo sapiens 1.91e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84984&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5379096 136351084 66103 ZINC14779854 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171988 COc1ccc(cc1)-c1cc(=O)c2c(O)c(OC)c(O)c(OC)c2o1 InChI=1S/C18H16O7/c1-22-10-6-4-9(5-7-10)12-8-11(19)13-14(20)17(23-2)15(21)18(24-3)16(13)25-12/h4-8,20-21H,1-3H3 KRFBMPVGAYGGJE-UHFFFAOYSA-N 84985 Nevadensin Mitogen-activated protein kinase 10 Homo sapiens 1.63e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84985&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 160921 136351085 C10111 ZINC00898952 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 171989 OC1C(=O)[C@@H](Oc2cc(O)cc(O)c12)c1ccc(O)c(O)c1 InChI=1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,13,15-20H/t13?,15-/m0/s1 BYVWXQRJRYELNP-WUJWULDRSA-N 84986 (+)-Taxifolin Mitogen-activated protein kinase 10 Homo sapiens 6.03e+4 37.00 C Curated from the literature by BindingDB 10.1002/cbic.201000487 10.7270/Q21C1VDT 21108268 aid1799639 Goettert, M; Schattel, V; Koch, P; Merfort, I; Laufer, S Eberhard Karls University of Tuebingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84986&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91538239 136351086 38747 ZINC00105082 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188567 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1 InChI=1S/C29H29N7O2/c1-20-8-11-24(18-26(20)35-29-31-16-14-25(34-29)22-6-4-15-30-19-22)33-28(38)21-9-12-23(13-10-21)32-27(37)7-5-17-36(2)3/h4-16,18-19H,17H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b7-5+ YFRXAAWSVLQGDR-FNORWQNLSA-N 86626 JNK-IN-1 Mitogen-activated protein kinase 10 Homo sapiens 7750 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25123232 136352675 ZINC87723487 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188568 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-22-12-10-20(11-13-22)27(37)32-23-7-3-8-24(18-23)33-28-30-16-14-25(34-28)21-6-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ VZEONOGFXYTZGT-WEVVVXLNSA-N 86627 JNK-IN-2 Mitogen-activated protein kinase 10 Homo sapiens 709 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340680 136352676 ZINC89464829 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188569 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Oc2nccc(n2)-c2cccnc2)c1 InChI=1S/C28H26N6O3/c1-34(2)17-5-9-26(35)31-22-12-10-20(11-13-22)27(36)32-23-7-3-8-24(18-23)37-28-30-16-14-25(33-28)21-6-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,35)(H,32,36)/b9-5+ GHUJSZOCHDRKQD-WEVVVXLNSA-N 86628 JNK-IN-3 Mitogen-activated protein kinase 10 Homo sapiens >10000 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86628&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340681 136352677 ZINC87723488 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188570 CN(C)C\C=C\C(=O)NCc1ccc(cc1)C(=O)Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1 InChI=1S/C29H29N7O2/c1-36(2)17-5-9-27(37)32-19-21-10-12-22(13-11-21)28(38)33-24-7-3-8-25(18-24)34-29-31-16-14-26(35-29)23-6-4-15-30-20-23/h3-16,18,20H,17,19H2,1-2H3,(H,32,37)(H,33,38)(H,31,34,35)/b9-5+ JFFMSXKMJYCOKJ-WEVVVXLNSA-N 86629 JNK-IN-4 Mitogen-activated protein kinase 10 Homo sapiens 7220 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86629&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340682 136352678 ZINC89464832 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188571 C=CC(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C25H20N6O2/c1-2-23(32)28-21-7-3-5-17(15-21)24(33)29-19-8-10-20(11-9-19)30-25-27-14-12-22(31-25)18-6-4-13-26-16-18/h2-16H,1H2,(H,28,32)(H,29,33)(H,27,30,31) LUFRTLQRKNBFAZ-UHFFFAOYSA-N 86630 JNK-IN-5 Mitogen-activated protein kinase 10 Homo sapiens 0.96 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86630&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340683 136352679 ZINC87723491 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188572 CCC(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C25H22N6O2/c1-2-23(32)28-21-7-3-5-17(15-21)24(33)29-19-8-10-20(11-9-19)30-25-27-14-12-22(31-25)18-6-4-13-26-16-18/h3-16H,2H2,1H3,(H,28,32)(H,29,33)(H,27,30,31) IDWIQPNYEMMAIA-UHFFFAOYSA-N 86631 JNK-IN-6 Mitogen-activated protein kinase 10 Homo sapiens 148 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86631&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340684 136352680 ZINC89464838 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188573 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ RADRIIWGHYFWPP-WEVVVXLNSA-N 86632 JNK-IN-7 Mitogen-activated protein kinase 10 Homo sapiens 0.75 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340685 136352681 ZINC87723492 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188574 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1 InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ GJFCSAPFHAXMSF-UXBLZVDNSA-N 86633 JNK-IN-8 Mitogen-activated protein kinase 10 Homo sapiens 0.98 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340686 136352682 ZINC89464842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188575 CN(C)C\C=C\C(=O)Nc1ccc(C)c(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C29H29N7O2/c1-20-8-9-24(32-27(37)7-5-17-36(2)3)18-25(20)28(38)33-22-10-12-23(13-11-22)34-29-31-16-14-26(35-29)21-6-4-15-30-19-21/h4-16,18-19H,17H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b7-5+ RSAFQYQXPHLUEC-FNORWQNLSA-N 86634 JNK-IN-9 Mitogen-activated protein kinase 10 Homo sapiens 0.50 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86634&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340687 136352683 ZINC87723495 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188576 CN(C)C\C=C\C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C29H29N7O2/c1-20-8-9-21(18-26(20)34-27(37)7-5-17-36(2)3)28(38)32-23-10-12-24(13-11-23)33-29-31-16-14-25(35-29)22-6-4-15-30-19-22/h4-16,18-19H,17H2,1-3H3,(H,32,38)(H,34,37)(H,31,33,35)/b7-5+ FFOGTAVNRXSARL-FNORWQNLSA-N 86635 JNK-IN-10 Mitogen-activated protein kinase 10 Homo sapiens 0.50 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86635&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340688 136352684 ZINC89464848 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188577 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2c(nn3ccccc23)-c2ccccc2)cc1 InChI=1S/C36H32N8O2/c1-43(2)22-9-15-32(45)38-29-13-8-12-26(24-29)35(46)39-27-16-18-28(19-17-27)40-36-37-21-20-30(41-36)33-31-14-6-7-23-44(31)42-34(33)25-10-4-3-5-11-25/h3-21,23-24H,22H2,1-2H3,(H,38,45)(H,39,46)(H,37,40,41)/b15-9+ OCZDPFMSAKKNRH-OQLLNIDSSA-N 86636 JNK-IN-11 Mitogen-activated protein kinase 10 Homo sapiens 0.50 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340689 136352685 ZINC89464853 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188578 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1 InChI=1S/C32H28N8O2S/c1-40(2)18-6-11-29(41)35-24-8-5-7-21(19-24)30(42)36-22-12-14-23(15-13-22)37-32-34-17-16-26(39-32)25(20-33)31-38-27-9-3-4-10-28(27)43-31/h3-17,19,25H,18H2,1-2H3,(H,35,41)(H,36,42)(H,34,37,39)/b11-6+ XLLHFYYRDKVYSQ-IZZDOVSWSA-N 86637 JNK-IN-12 Mitogen-activated protein kinase 10 Homo sapiens 11.0 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86637&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91899090 136352686 ZINC89464860 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188579 O=C(Nc1sc2CCCCc2c1C#N)c1cccc2ccccc12 InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23) WQGDQGAFSDMBLA-UHFFFAOYSA-N 86638 Name not given Mitogen-activated protein kinase 10 Homo sapiens 200 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86638&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 766949 136352687 ZINC00244029 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188580 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 190 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 188581 N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1 InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) RCYPVQCPYKNSTG-UHFFFAOYSA-N 50169959 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile::AS-601245::AS601245::CHEMBL1788116::CHEMBL191384::[3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile Mitogen-activated protein kinase 10 Homo sapiens 70 Curated from the literature by BindingDB 10.1016/j.chembiol.2011.11.010 10.7270/Q2K35S8X 22284361 aid1799705 Zhang, T; Inesta-Vaquera, F; Niepel, M; Zhang, J; Ficarro, SB; Machleidt, T; Xie, T; Marto, JA; Kim, N; Sim, T; Laughlin, JD; Park, H; LoGrasso, PV; Patricelli, M; Nomanbhoy, TK; Sorger, PK; Alessi, DR; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169959&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JN5 3CY3 10109823 104054707 CHEMBL1788116CHEMBL191384 5997 ZINC13647791 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 200725 COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3)cn2)cc(OC)c1OC InChI=1S/C26H25N5O5/c1-34-22-13-19(14-23(35-2)24(22)36-3)28-25(32)17-8-7-11-21(12-17)31-16-20(15-27-31)30-26(33)29-18-9-5-4-6-10-18/h4-16H,1-3H3,(H,28,32)(H2,29,30,33) RQEFLPVRZJPIAZ-UHFFFAOYSA-N 92522 Aminopyrazole inhibitor, 3451 Mitogen-activated protein kinase 10 Homo sapiens 25 7 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M809430200 10.7270/Q2NZ867T 19261605 aid1799794 Kamenecka, T; Habel, J; Duckett, D; Chen, W; Ling, YY; Frackowiak, B; Jiang, R; Shin, Y; Song, X; LoGrasso, P The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92522&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JK1 3FI2 49867175 160845019 ZINC39232470 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 200726 COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cc(OC)c1OC InChI=1S/C26H24ClN5O5/c1-35-22-12-17(13-23(36-2)24(22)37-3)29-25(33)16-7-6-8-19(11-16)32-15-18(14-28-32)30-26(34)31-21-10-5-4-9-20(21)27/h4-15H,1-3H3,(H,29,33)(H2,30,31,34) PANZFUIIZSOBRK-UHFFFAOYSA-N 92523 Aminopyrazole inhibitor, 3528 Mitogen-activated protein kinase 10 Homo sapiens 23 7 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M809430200 10.7270/Q2NZ867T 19261605 aid1799794 Kamenecka, T; Habel, J; Duckett, D; Chen, W; Ling, YY; Frackowiak, B; Jiang, R; Shin, Y; Song, X; LoGrasso, P The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92523&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702007 160845020 ZINC87613135 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 200727 COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3cccc(C)c3)cn2)cc(OC)c1OC InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34) MTFAYLZZDJGFGV-UHFFFAOYSA-N 92524 Aminopyrazole inhibitor, 3576 Mitogen-activated protein kinase 10 Homo sapiens 7 7 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M809430200 10.7270/Q2NZ867T 19261605 aid1799794 Kamenecka, T; Habel, J; Duckett, D; Chen, W; Ling, YY; Frackowiak, B; Jiang, R; Shin, Y; Song, X; LoGrasso, P The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92524&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702008 160845021 ZINC71773480 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 200728 COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccc(Cl)cc3)cn2)cc(OC)c1OC InChI=1S/C26H24ClN5O5/c1-35-22-12-19(13-23(36-2)24(22)37-3)29-25(33)16-5-4-6-21(11-16)32-15-20(14-28-32)31-26(34)30-18-9-7-17(27)8-10-18/h4-15H,1-3H3,(H,29,33)(H2,30,31,34) QRRNJRGTBDNDSQ-UHFFFAOYSA-N 92525 Aminopyrazole inhibitor, 3583 Mitogen-activated protein kinase 10 Homo sapiens 4.8e+2 7 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M809430200 10.7270/Q2NZ867T 19261605 aid1799794 Kamenecka, T; Habel, J; Duckett, D; Chen, W; Ling, YY; Frackowiak, B; Jiang, R; Shin, Y; Song, X; LoGrasso, P The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92525&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702009 160845022 ZINC87613136 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 200729 Cc1cncc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)c1 InChI=1S/C23H19ClN6O2/c1-15-9-17(12-25-11-15)27-22(31)16-5-4-6-19(10-16)30-14-18(13-26-30)28-23(32)29-21-8-3-2-7-20(21)24/h2-14H,1H3,(H,27,31)(H2,28,29,32) KVVQUXAGSWSMKF-UHFFFAOYSA-N 92526 Aminopyrazole inhibitor, 4326 Mitogen-activated protein kinase 10 Homo sapiens 55 7 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M809430200 10.7270/Q2NZ867T 19261605 aid1799794 Kamenecka, T; Habel, J; Duckett, D; Chen, W; Ling, YY; Frackowiak, B; Jiang, R; Shin, Y; Song, X; LoGrasso, P The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92526&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702010 160845023 ZINC89469634 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 200730 CN(C)c1cc(cc(c1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1)C(=O)Nc1cncc(C)c1 InChI=1S/C25H24ClN7O2/c1-16-8-18(13-27-12-16)29-24(34)17-9-20(32(2)3)11-21(10-17)33-15-19(14-28-33)30-25(35)31-23-7-5-4-6-22(23)26/h4-15H,1-3H3,(H,29,34)(H2,30,31,35) VYOSPNKDVZPXGE-UHFFFAOYSA-N 92527 Aminopyrazole inhibitor, 4642 Mitogen-activated protein kinase 10 Homo sapiens 2.2e+3 7 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M809430200 10.7270/Q2NZ867T 19261605 aid1799794 Kamenecka, T; Habel, J; Duckett, D; Chen, W; Ling, YY; Frackowiak, B; Jiang, R; Shin, Y; Song, X; LoGrasso, P The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92527&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702011 160845024 ZINC87613137 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 200731 Cc1cncc(NC(=O)c2cc(cc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)N2CCOCC2)c1 InChI=1S/C27H26ClN7O3/c1-18-10-20(15-29-14-18)31-26(36)19-11-22(34-6-8-38-9-7-34)13-23(12-19)35-17-21(16-30-35)32-27(37)33-25-5-3-2-4-24(25)28/h2-5,10-17H,6-9H2,1H3,(H,31,36)(H2,32,33,37) SCYPRAPAYLZPID-UHFFFAOYSA-N 92528 Aminopyrazole inhibitor, 4643 Mitogen-activated protein kinase 10 Homo sapiens 1.5e+3 7 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M809430200 10.7270/Q2NZ867T 19261605 aid1799794 Kamenecka, T; Habel, J; Duckett, D; Chen, W; Ling, YY; Frackowiak, B; Jiang, R; Shin, Y; Song, X; LoGrasso, P The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92528&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702012 160845025 ZINC89469636 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 200732 Cc1cccc(NC(=O)Nc2cnn(c2)-c2cccc(c2)C(=O)NCCN2CCOCC2)c1 InChI=1S/C24H28N6O3/c1-18-4-2-6-20(14-18)27-24(32)28-21-16-26-30(17-21)22-7-3-5-19(15-22)23(31)25-8-9-29-10-12-33-13-11-29/h2-7,14-17H,8-13H2,1H3,(H,25,31)(H2,27,28,32) ZTOSXXBNZHZMNU-UHFFFAOYSA-N 92529 Aminopyrazole inhibitor, 4018 Mitogen-activated protein kinase 10 Homo sapiens 2.1e+3 7 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M809430200 10.7270/Q2NZ867T 19261605 aid1799794 Kamenecka, T; Habel, J; Duckett, D; Chen, W; Ling, YY; Frackowiak, B; Jiang, R; Shin, Y; Song, X; LoGrasso, P The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92529&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702013 160845026 ZINC87613138 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 200733 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)NCCCN1CCOCC1 InChI=1S/C24H27ClN6O3/c25-21-7-1-2-8-22(21)29-24(33)28-19-16-27-31(17-19)20-6-3-5-18(15-20)23(32)26-9-4-10-30-11-13-34-14-12-30/h1-3,5-8,15-17H,4,9-14H2,(H,26,32)(H2,28,29,33) MTMPXCITEXTRGD-UHFFFAOYSA-N 92530 Aminopyrazole inhibitor, 4276 Mitogen-activated protein kinase 10 Homo sapiens 3.5e+2 7 22.00 C Curated from the literature by BindingDB 10.1074/jbc.M809430200 10.7270/Q2NZ867T 19261605 aid1799794 Kamenecka, T; Habel, J; Duckett, D; Chen, W; Ling, YY; Frackowiak, B; Jiang, R; Shin, Y; Song, X; LoGrasso, P The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92530&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702014 160845027 ZINC89469638 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 222129 COc1cc(ccc1OCC(C)(C)O)-n1ccc(CNc2ccc(Cl)cc2)cc1=O InChI=1S/C23H25ClN2O4/c1-23(2,28)15-30-20-9-8-19(13-21(20)29-3)26-11-10-16(12-22(26)27)14-25-18-6-4-17(24)5-7-18/h4-13,25,28H,14-15H2,1-3H3 OWVJFLOWTRTEOY-UHFFFAOYSA-N 103904 JNK3 inhibitor 1::US8563583, A-33 Mitogen-activated protein kinase 10 Homo sapiens 37.8 Curated from the literature by BindingDB 10.1021/cb3006165 10.7270/Q25719PN 23751758 Feng, Y; Chambers, JW; Iqbal, S; Koenig, M; Park, H; Cherry, L; Hernandez, P; Figuera-Losada, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103904&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46911144 172541664 ZINC96174686 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 222130 COc1cc(ccc1OCCO)-n1ccc(cc1=O)-c1ccc(OC(F)(F)F)cc1 InChI=1S/C21H18F3NO5/c1-28-19-13-16(4-7-18(19)29-11-10-26)25-9-8-15(12-20(25)27)14-2-5-17(6-3-14)30-21(22,23)24/h2-9,12-13,26H,10-11H2,1H3 JCLKKRZMUZBICB-UHFFFAOYSA-N 103905 JNK3 inhibitor 2::US8563583, C-1 Mitogen-activated protein kinase 10 Homo sapiens 135.5 Curated from the literature by BindingDB 10.1021/cb3006165 10.7270/Q25719PN 23751758 Feng, Y; Chambers, JW; Iqbal, S; Koenig, M; Park, H; Cherry, L; Hernandez, P; Figuera-Losada, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103905&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46911310 172541665 ZINC96174688 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 222131 COc1cc(ccc1OCC(C)(C)O)-n1ccc(cc1=O)-c1ccc(cc1)C(F)(F)F InChI=1S/C23H22F3NO4/c1-22(2,29)14-31-19-9-8-18(13-20(19)30-3)27-11-10-16(12-21(27)28)15-4-6-17(7-5-15)23(24,25)26/h4-13,29H,14H2,1-3H3 HDLPZLIRDMOMBU-UHFFFAOYSA-N 103906 JNK3 inhibitor 3::US8563583, B-2 Mitogen-activated protein kinase 10 Homo sapiens 157.5 Curated from the literature by BindingDB 10.1021/cb3006165 10.7270/Q25719PN 23751758 Feng, Y; Chambers, JW; Iqbal, S; Koenig, M; Park, H; Cherry, L; Hernandez, P; Figuera-Losada, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103906&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46911147 172541666 ZINC96174690 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 222132 COc1cc(ccc1OCC(C)(C)O)-n1ccc(SCc2ccc(Cl)cc2)cc1=O InChI=1S/C23H24ClNO4S/c1-23(2,27)15-29-20-9-8-18(12-21(20)28-3)25-11-10-19(13-22(25)26)30-14-16-4-6-17(24)7-5-16/h4-13,27H,14-15H2,1-3H3 HWSUJLBBZVSJFM-UHFFFAOYSA-N 103907 JNK3 inhibitor 4::US8563583, D-4 Mitogen-activated protein kinase 10 Homo sapiens 147.4 Curated from the literature by BindingDB 10.1021/cb3006165 10.7270/Q25719PN 23751758 Feng, Y; Chambers, JW; Iqbal, S; Koenig, M; Park, H; Cherry, L; Hernandez, P; Figuera-Losada, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103907&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46911363 172541667 ZINC96174691 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 222133 NOOSc1ccc(CC[N]23CC4=CC=CC=[N]4[Re+]2[N]2=C(C3)C=CC=C2)cc1 InChI=1S/C20H22N4O2S.Re/c21-25-26-27-20-9-7-17(8-10-20)11-14-24(15-18-5-1-3-12-22-18)16-19-6-2-4-13-23-19;/h1-10,12-13H,11,14-16,21H2;/q;+1 QEGBEHYDGMZGRV-UHFFFAOYSA-N 103908 JNK3 inhibitor 5::US8562945, 241 Mitogen-activated protein kinase 10 Homo sapiens 63.4 Curated from the literature by BindingDB 10.1021/cb3006165 10.7270/Q25719PN 23751758 Feng, Y; Chambers, JW; Iqbal, S; Koenig, M; Park, H; Cherry, L; Hernandez, P; Figuera-Losada, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103908&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59404289 172541668 ZINC96174693 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 222134 NOOSc1ccc(CC[N@@]23CC(=O)O[Re]2[N]2=C(C3)C=CC=C2)cc1 InChI=1S/C16H19N3O4S.Re/c17-22-23-24-15-6-4-13(5-7-15)8-10-19(12-16(20)21)11-14-3-1-2-9-18-14;/h1-7,9H,8,10-12,17H2,(H,20,21);/q;+1/p-1 IIDDSQRWDXXIIL-UHFFFAOYSA-M 103909 JNK3 inhibitor 6::US8562945, 242 Mitogen-activated protein kinase 10 Homo sapiens 11.6 Curated from the literature by BindingDB 10.1021/cb3006165 10.7270/Q25719PN 23751758 Feng, Y; Chambers, JW; Iqbal, S; Koenig, M; Park, H; Cherry, L; Hernandez, P; Figuera-Losada, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103909&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59404295 172541669 ZINC96174695 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 222135 CN1C=C[N]2=C1C[N]1(CCc3ccc(SOON)cc3)CC3=[N](C=CN3C)[Re+]21 InChI=1S/C18H24N6O2S.Re/c1-22-11-8-20-17(22)13-24(14-18-21-9-12-23(18)2)10-7-15-3-5-16(6-4-15)27-26-25-19;/h3-6,8-9,11-12H,7,10,13-14,19H2,1-2H3;/q;+1 JDWVJCDXGFYOOF-UHFFFAOYSA-N 103910 JNK3 inhibitor 7::US8562945, 243 Mitogen-activated protein kinase 10 Homo sapiens 126.7 Curated from the literature by BindingDB 10.1021/cb3006165 10.7270/Q25719PN 23751758 Feng, Y; Chambers, JW; Iqbal, S; Koenig, M; Park, H; Cherry, L; Hernandez, P; Figuera-Losada, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103910&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59404334 172541670 ZINC96174697 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 222136 NOOSc1ccc(NC(=S)NCCCCCCCC[N]23CC4=CC=CC=[N]4[Re+]2[N]2=C(C3)C=CC=C2)cc1 InChI=1S/C27H36N6O2S2.Re/c28-34-35-37-26-15-13-23(14-16-26)32-27(36)31-19-7-3-1-2-4-10-20-33(21-24-11-5-8-17-29-24)22-25-12-6-9-18-30-25;/h5-6,8-9,11-18H,1-4,7,10,19-22,28H2,(H2,31,32,36);/q;+1 RWVAZDWYGSNEJK-UHFFFAOYSA-N 103911 JNK3 inhibitor 8::US8562945, 246 Mitogen-activated protein kinase 10 Homo sapiens 3154 Curated from the literature by BindingDB 10.1021/cb3006165 10.7270/Q25719PN 23751758 Feng, Y; Chambers, JW; Iqbal, S; Koenig, M; Park, H; Cherry, L; Hernandez, P; Figuera-Losada, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103911&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59404276 172541671 ZINC96174699 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 222137 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 220 Curated from the literature by BindingDB 10.1021/cb3006165 10.7270/Q25719PN 23751758 Feng, Y; Chambers, JW; Iqbal, S; Koenig, M; Park, H; Cherry, L; Hernandez, P; Figuera-Losada, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 250130 O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1 HDAJDNHIBCDLQF-RUZDIDTESA-N 103302 SCH772984::US8546404, 6 Mitogen-activated protein kinase 10 Homo sapiens 632 Curated from the literature by BindingDB 10.1038/nchembio.1629 10.7270/Q28G8JCH 25195011 aid1800457 Chaikuad, A; Tacconi, EM; Zimmer, J; Liang, Y; Gray, NS; Tarsounas, M; Knapp, S George Washington University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=103302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=103302&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70997213 172098593 ZINC96174209 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50065278 O=C1c2ccccc2-c2[nH]nc3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 50433916 PS653 ('1,6-dihydrodibenzo[c,d,g]indazol-6-one)::SP-600125 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1073/pnas.0708800104 10.7270/Q2DB82RH 18077363 Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Muller, S; Bullock, AN; Schwaller, J; Sundstrom, M; Knapp, S University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433916&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 8515 175446233 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50079764 Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1 InChI=1S/C17H13N3O/c21-12-5-3-4-11(10-12)19-15-8-9-18-17-16(15)13-6-1-2-7-14(13)20-17/h1-10,21H,(H2,18,19,20) RXPZOSHFGJWSLQ-UHFFFAOYSA-N 50001733 CHEMBL3133821 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2014.03.002 10.7270/Q2TM7CN0 24650640 Mahmoud, KA; Krug, M; Wersig, T; Slynko, I; Schächtele, C; Totzke, F; Sippl, W; Hilgeroth, A Martin-Luther-University Halle-Wittenberg http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001733&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 76332983 242055993 CHEMBL3133821 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50126299 Oc1c2cccc3N=Nc(c23)c2ccccc12 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,17H KRIUNPBAQZGFQA-UHFFFAOYSA-N 50024294 SP-600125 Mitogen-activated protein kinase 10 Homo sapiens 22 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50024294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50024294&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 8515 277286496 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50126316 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 10 Homo sapiens 340 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search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itogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50165481 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Mitogen-activated protein kinase 10 Homo sapiens 3600 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50166310 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Mitogen-activated protein kinase 10 Homo sapiens 12 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50187042 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search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itogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50183998 COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- XZXHXSATPCNXJR-ZIADKAODSA-N 50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef Mitogen-activated protein kinase 10 Homo sapiens 270 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026612&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search XIN 5MAF,6NEC,3C7Q,5TE0 9809715 277286638 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50191334 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Mitogen-activated protein kinase 10 Homo sapiens 3600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50194818 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Mitogen-activated protein kinase 10 Homo sapiens 12 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50221657 Fc1ccc(c(F)c1)-c1cc(cc2N(C(=O)NCc12)c1c(Cl)cccc1Cl)C1CCNCC1 InChI=1S/C25H21Cl2F2N3O/c26-20-2-1-3-21(27)24(20)32-23-11-15(14-6-8-30-9-7-14)10-18(19(23)13-31-25(32)33)17-5-4-16(28)12-22(17)29/h1-5,10-12,14,30H,6-9,13H2,(H,31,33) NEQVXWUMTYNMHH-UHFFFAOYSA-N 17060 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(piperidin-4-yl)-1,2,3,4-tetrahydroquinazolin-2-one::CHEMBL319556::Dihydro-quinazolinone analog, 9 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/s0960-894x(02)00752-7 10.7270/Q25X2884 12482439 Stelmach, JE; Liu, L; Patel, SB; Pivnichny, JV; Scapin, G; Singh, S; Hop, CE; Wang, Z; Strauss, JR; Cameron, PM; Nichols, EA; O'Keefe, SJ; O'Neill, EA; Schmatz, DM; Schwartz, CD; Thompson, CM; Zaller, DM; Doherty, JB Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17060&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 23532567 46517290 CHEMBL319556 ZINC13487116 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50228794 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search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itogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50230475 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Mitogen-activated protein kinase 10 Homo sapiens 3600 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248164 Cc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)ccn1 InChI=1S/C23H19ClN6O2/c1-15-11-17(9-10-25-15)27-22(31)16-5-4-6-19(12-16)30-14-18(13-26-30)28-23(32)29-21-8-3-2-7-20(21)24/h2-14H,1H3,(H,25,27,31)(H2,28,29,32) XMZFQCOWVFCHQO-UHFFFAOYSA-N 50032745 CHEMBL3355165 Mitogen-activated protein kinase 10 Homo sapiens 866 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032745&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3H8 4W4V 87057579 103941200 CHEMBL3355165 ZINC36349912 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248165 Cc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cc(C)n1 InChI=1S/C24H21ClN6O2/c1-15-10-18(11-16(2)27-15)28-23(32)17-6-5-7-20(12-17)31-14-19(13-26-31)29-24(33)30-22-9-4-3-8-21(22)25/h3-14H,1-2H3,(H,27,28,32)(H2,29,30,33) QUBFVDVWHOIYRD-UHFFFAOYSA-N 50032746 CHEMBL3355166 Mitogen-activated protein kinase 10 Homo sapiens 2331 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032746&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146748 103941201 CHEMBL3355166 ZINC36349916 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248167 Cc1ccc(CNC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C24H21ClN6O2/c1-16-9-10-17(12-26-16)13-27-23(32)18-5-4-6-20(11-18)31-15-19(14-28-31)29-24(33)30-22-8-3-2-7-21(22)25/h2-12,14-15H,13H2,1H3,(H,27,32)(H2,29,30,33) OYICHVOOWWQYDE-UHFFFAOYSA-N 50032747 CHEMBL3355168 Mitogen-activated protein kinase 10 Homo sapiens 905 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032747&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146884 103941202 CHEMBL3355168 ZINC36349935 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248169 CC(C)n1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C23H22ClN7O2/c1-15(2)30-13-17(11-25-30)27-22(32)16-6-5-7-19(10-16)31-14-18(12-26-31)28-23(33)29-21-9-4-3-8-20(21)24/h3-15H,1-2H3,(H,27,32)(H2,28,29,33) CUDZNCZDKGCXRX-UHFFFAOYSA-N 50032748 CHEMBL3355174 Mitogen-activated protein kinase 10 Homo sapiens 3250 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032748&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118144367 103941203 CHEMBL3355174 ZINC13742726 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248171 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)Nc1cnn(c1)C1CCNCC1 InChI=1S/C25H25ClN8O2/c26-22-6-1-2-7-23(22)32-25(36)31-19-14-29-34(16-19)21-5-3-4-17(12-21)24(35)30-18-13-28-33(15-18)20-8-10-27-11-9-20/h1-7,12-16,20,27H,8-11H2,(H,30,35)(H2,31,32,36) ILUOKEKSMZBBQY-UHFFFAOYSA-N 50032749 CHEMBL3355177 Mitogen-activated protein kinase 10 Homo sapiens 1436 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032749&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146882 103941204 CHEMBL3355177 ZINC36349932 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248173 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)NCC1CCNCC1 InChI=1S/C23H25ClN6O2/c24-20-6-1-2-7-21(20)29-23(32)28-18-14-27-30(15-18)19-5-3-4-17(12-19)22(31)26-13-16-8-10-25-11-9-16/h1-7,12,14-16,25H,8-11,13H2,(H,26,31)(H2,28,29,32) XDNOBDTYZKRSTK-UHFFFAOYSA-N 50032750 CHEMBL3355181 Mitogen-activated protein kinase 10 Homo sapiens 1895 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032750&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 86763302 103941205 CHEMBL3355181 ZINC13742728 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248177 CC(C)n1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C23H22ClN7O2/c1-15(2)30-13-17(11-25-30)27-22(32)16-6-5-7-19(10-16)31-14-18(12-26-31)28-23(33)29-21-9-4-3-8-20(21)24/h3-15H,1-2H3,(H,27,32)(H2,28,29,33) CUDZNCZDKGCXRX-UHFFFAOYSA-N 50032748 CHEMBL3355174 Mitogen-activated protein kinase 10 Homo sapiens 114 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032748&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118144367 103941203 CHEMBL3355174 ZINC13742726 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248179 Cn1cnc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)n1 InChI=1S/C20H17ClN8O2/c1-28-12-22-19(27-28)26-18(30)13-5-4-6-15(9-13)29-11-14(10-23-29)24-20(31)25-17-8-3-2-7-16(17)21/h2-12H,1H3,(H2,24,25,31)(H,26,27,30) WWNTZNJRZKYEDT-UHFFFAOYSA-N 50032751 CHEMBL3355173 Mitogen-activated protein kinase 10 Homo sapiens 594 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032751&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146873 103941206 CHEMBL3355173 ZINC01540190 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248180 Cc1nn(C)cc1NC(=O)c1cccc(c1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C22H20ClN7O2/c1-14-20(13-29(2)28-14)26-21(31)15-6-5-7-17(10-15)30-12-16(11-24-30)25-22(32)27-19-9-4-3-8-18(19)23/h3-13H,1-2H3,(H,26,31)(H2,25,27,32) JPFBEXNTFDBDPO-UHFFFAOYSA-N 50032752 CHEMBL3355172 Mitogen-activated protein kinase 10 Homo sapiens 116 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032752&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146874 103941207 CHEMBL3355172 ZINC36349892 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248182 Cn1nccc1NC(=O)c1cccc(c1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C21H18ClN7O2/c1-28-19(9-10-23-28)27-20(30)14-5-4-6-16(11-14)29-13-15(12-24-29)25-21(31)26-18-8-3-2-7-17(18)22/h2-13H,1H3,(H,27,30)(H2,25,26,31) TWJFMLHANAPHIP-UHFFFAOYSA-N 50032753 CHEMBL3355171 Mitogen-activated protein kinase 10 Homo sapiens 162 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032753&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146826 103941208 CHEMBL3355171 ZINC01540191 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248187 Cn1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)n1 InChI=1S/C21H18ClN7O2/c1-28-10-9-19(27-28)26-20(30)14-5-4-6-16(11-14)29-13-15(12-23-29)24-21(31)25-18-8-3-2-7-17(18)22/h2-13H,1H3,(H2,24,25,31)(H,26,27,30) CAAOJOMUHVKROQ-UHFFFAOYSA-N 50032754 CHEMBL3355170 Mitogen-activated protein kinase 10 Homo sapiens 203 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032754&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146828 103941209 CHEMBL3355170 ZINC03809486 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248188 Cn1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C21H18ClN7O2/c1-28-12-15(10-23-28)25-20(30)14-5-4-6-17(9-14)29-13-16(11-24-29)26-21(31)27-19-8-3-2-7-18(19)22/h2-13H,1H3,(H,25,30)(H2,26,27,31) UVNAKPQGTLWFDT-UHFFFAOYSA-N 50032755 CHEMBL3355169 Mitogen-activated protein kinase 10 Homo sapiens 133 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032755&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118144281 103941210 CHEMBL3355169 ZINC43335331 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248189 Cc1ccc(CNC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C24H21ClN6O2/c1-16-9-10-17(12-26-16)13-27-23(32)18-5-4-6-20(11-18)31-15-19(14-28-31)29-24(33)30-22-8-3-2-7-21(22)25/h2-12,14-15H,13H2,1H3,(H,27,32)(H2,29,30,33) OYICHVOOWWQYDE-UHFFFAOYSA-N 50032747 CHEMBL3355168 Mitogen-activated protein kinase 10 Homo sapiens 311 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032747&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146884 103941202 CHEMBL3355168 ZINC36349935 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248190 Cc1ncc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C22H18ClN7O2/c1-14-24-10-16(11-25-14)27-21(31)15-5-4-6-18(9-15)30-13-17(12-26-30)28-22(32)29-20-8-3-2-7-19(20)23/h2-13H,1H3,(H,27,31)(H2,28,29,32) SRJUPLSEYKRYTF-UHFFFAOYSA-N 50032756 CHEMBL3355167 Mitogen-activated protein kinase 10 Homo sapiens 62 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032756&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118144359 103941211 CHEMBL3355167 ZINC36349901 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248191 Cc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cc(C)n1 InChI=1S/C24H21ClN6O2/c1-15-10-18(11-16(2)27-15)28-23(32)17-6-5-7-20(12-17)31-14-19(13-26-31)29-24(33)30-22-9-4-3-8-21(22)25/h3-14H,1-2H3,(H,27,28,32)(H2,29,30,33) QUBFVDVWHOIYRD-UHFFFAOYSA-N 50032746 CHEMBL3355166 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032746&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146748 103941201 CHEMBL3355166 ZINC36349916 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248193 Cc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)ccn1 InChI=1S/C23H19ClN6O2/c1-15-11-17(9-10-25-15)27-22(31)16-5-4-6-19(12-16)30-14-18(13-26-30)28-23(32)29-21-8-3-2-7-20(21)24/h2-14H,1H3,(H,25,27,31)(H2,28,29,32) XMZFQCOWVFCHQO-UHFFFAOYSA-N 50032745 CHEMBL3355165 Mitogen-activated protein kinase 10 Homo sapiens 98 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032745&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3H8 4W4V 87057579 103941200 CHEMBL3355165 ZINC36349912 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248197 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)nc1 InChI=1S/C23H19ClN6O2/c1-15-9-10-21(25-12-15)29-22(31)16-5-4-6-18(11-16)30-14-17(13-26-30)27-23(32)28-20-8-3-2-7-19(20)24/h2-14H,1H3,(H,25,29,31)(H2,27,28,32) XQODOKHOHBRDFP-UHFFFAOYSA-N 50032757 CHEMBL3355164 Mitogen-activated protein kinase 10 Homo sapiens 5184 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032757&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146794 103941212 CHEMBL3355164 ZINC13742735 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248199 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)c(C)n1 InChI=1S/C24H21ClN6O2/c1-15-10-11-21(16(2)27-15)29-23(32)17-6-5-7-19(12-17)31-14-18(13-26-31)28-24(33)30-22-9-4-3-8-20(22)25/h3-14H,1-2H3,(H,29,32)(H2,28,30,33) XBNYVHUQFWTQPZ-UHFFFAOYSA-N 50032777 CHEMBL3355162 Mitogen-activated protein kinase 10 Homo sapiens 141 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032777&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146932 103941232 CHEMBL3355162 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248200 Cc1ncccc1NC(=O)c1cccc(c1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C23H19ClN6O2/c1-15-20(10-5-11-25-15)28-22(31)16-6-4-7-18(12-16)30-14-17(13-26-30)27-23(32)29-21-9-3-2-8-19(21)24/h2-14H,1H3,(H,28,31)(H2,27,29,32) VJASHVRNRXKEGV-UHFFFAOYSA-N 50032799 CHEMBL3355161 Mitogen-activated protein kinase 10 Homo sapiens 141 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032799&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146727 103941254 CHEMBL3355161 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248201 Cc1cncc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)c1 InChI=1S/C23H19ClN6O2/c1-15-9-17(12-25-11-15)27-22(31)16-5-4-6-19(10-16)30-14-18(13-26-30)28-23(32)29-21-8-3-2-7-20(21)24/h2-14H,1H3,(H,27,31)(H2,28,29,32) KVVQUXAGSWSMKF-UHFFFAOYSA-N 92526 Aminopyrazole inhibitor, 4326 Mitogen-activated protein kinase 10 Homo sapiens 117 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92526&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702010 160845023 ZINC89469634 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248202 Cc1ccc(NC(=O)c2cccc(c2F)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C23H18ClFN6O2/c1-14-9-10-15(11-26-14)28-22(32)17-5-4-8-20(21(17)25)31-13-16(12-27-31)29-23(33)30-19-7-3-2-6-18(19)24/h2-13H,1H3,(H,28,32)(H2,29,30,33) GSDDEGTUTVNHGA-UHFFFAOYSA-N 50032806 CHEMBL3355159 Mitogen-activated protein kinase 10 Homo sapiens 230 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032806&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118144051 312528593 CHEMBL3355159 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248203 Cc1ccc(NC(=O)c2cc(ccc2F)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C23H18ClFN6O2/c1-14-6-7-15(11-26-14)28-22(32)18-10-17(8-9-20(18)25)31-13-16(12-27-31)29-23(33)30-21-5-3-2-4-19(21)24/h2-13H,1H3,(H,28,32)(H2,29,30,33) GFABXPYEGAFBKF-UHFFFAOYSA-N 50032807 CHEMBL3355158 Mitogen-activated protein kinase 10 Homo sapiens 71 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032807&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146793 312528594 CHEMBL3355158 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248208 Cc1ccc(NC(=O)c2cc(F)cc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C23H18ClFN6O2/c1-14-6-7-17(11-26-14)28-22(32)15-8-16(25)10-19(9-15)31-13-18(12-27-31)29-23(33)30-21-5-3-2-4-20(21)24/h2-13H,1H3,(H,28,32)(H2,29,30,33) GBDWGRMUSAPQKS-UHFFFAOYSA-N 50032808 CHEMBL3355157 Mitogen-activated protein kinase 10 Homo sapiens 4588 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032808&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146798 312528595 CHEMBL3355157 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248209 Cc1ccc(NC(=O)c2ccc(F)c(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C23H18ClFN6O2/c1-14-6-8-16(11-26-14)28-22(32)15-7-9-19(25)21(10-15)31-13-17(12-27-31)29-23(33)30-20-5-3-2-4-18(20)24/h2-13H,1H3,(H,28,32)(H2,29,30,33) JVSLZGKNRZILCQ-UHFFFAOYSA-N 50032809 CHEMBL3355156 Mitogen-activated protein kinase 10 Homo sapiens 80 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032809&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146855 312528596 CHEMBL3355156 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248210 CN(C(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)Nc1ccc(C)nc1)c1ccccc1Cl InChI=1S/C24H21ClN6O2/c1-16-10-11-18(13-26-16)28-23(32)17-6-5-7-20(12-17)31-15-19(14-27-31)29-24(33)30(2)22-9-4-3-8-21(22)25/h3-15H,1-2H3,(H,28,32)(H,29,33) LOJAYFJVFDUSOU-UHFFFAOYSA-N 50032810 CHEMBL3355153 Mitogen-activated protein kinase 10 Homo sapiens 3063 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032810&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146797 312528597 CHEMBL3355153 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248211 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccc(F)cc3)cn2)cn1 InChI=1S/C23H19FN6O2/c1-15-5-8-19(12-25-15)27-22(31)16-3-2-4-21(11-16)30-14-20(13-26-30)29-23(32)28-18-9-6-17(24)7-10-18/h2-14H,1H3,(H,27,31)(H2,28,29,32) GGJMKFUHJIIZJP-UHFFFAOYSA-N 50032811 CHEMBL3355151 Mitogen-activated protein kinase 10 Homo sapiens 162 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032811&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146814 312528598 CHEMBL3355151 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248212 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3cccc(F)c3)cn2)cn1 InChI=1S/C23H19FN6O2/c1-15-8-9-19(12-25-15)27-22(31)16-4-2-7-21(10-16)30-14-20(13-26-30)29-23(32)28-18-6-3-5-17(24)11-18/h2-14H,1H3,(H,27,31)(H2,28,29,32) HMLQTEJXWLWZJQ-UHFFFAOYSA-N 50032812 CHEMBL3355150 Mitogen-activated protein kinase 10 Homo sapiens 139 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032812&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146984 312528599 CHEMBL3355150 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248215 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3F)cn2)cn1 InChI=1S/C23H19FN6O2/c1-15-9-10-17(12-25-15)27-22(31)16-5-4-6-19(11-16)30-14-18(13-26-30)28-23(32)29-21-8-3-2-7-20(21)24/h2-14H,1H3,(H,27,31)(H2,28,29,32) DGFDDBSHXCJUNO-UHFFFAOYSA-N 50032813 CHEMBL3355149 Mitogen-activated protein kinase 10 Homo sapiens 313 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032813&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146849 312528600 CHEMBL3355149 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248216 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccc(Cl)cc3)cn2)cn1 InChI=1S/C23H19ClN6O2/c1-15-5-8-19(12-25-15)27-22(31)16-3-2-4-21(11-16)30-14-20(13-26-30)29-23(32)28-18-9-6-17(24)7-10-18/h2-14H,1H3,(H,27,31)(H2,28,29,32) VTZNGGPLNCCQIL-UHFFFAOYSA-N 50032814 CHEMBL3355148 Mitogen-activated protein kinase 10 Homo sapiens 1829 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032814&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118720656 312528601 CHEMBL3355148 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248219 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3cccc(Cl)c3)cn2)cn1 InChI=1S/C23H19ClN6O2/c1-15-8-9-19(12-25-15)27-22(31)16-4-2-7-21(10-16)30-14-20(13-26-30)29-23(32)28-18-6-3-5-17(24)11-18/h2-14H,1H3,(H,27,31)(H2,28,29,32) DUEOSPHFDUWPFC-UHFFFAOYSA-N 50032815 CHEMBL3355147 Mitogen-activated protein kinase 10 Homo sapiens 596 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032815&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118720655 312528602 CHEMBL3355147 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248220 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C23H19ClN6O2/c1-15-9-10-17(12-25-15)27-22(31)16-5-4-6-19(11-16)30-14-18(13-26-30)28-23(32)29-21-8-3-2-7-20(21)24/h2-14H,1H3,(H,27,31)(H2,28,29,32) QAPNZNFLFCTLFN-UHFFFAOYSA-N 50032816 CHEMBL3355146 Mitogen-activated protein kinase 10 Homo sapiens 38 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032816&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118143962 312528603 CHEMBL3355146 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248221 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3)cn2)cn1 InChI=1S/C23H20N6O2/c1-16-10-11-19(13-24-16)26-22(30)17-6-5-9-21(12-17)29-15-20(14-25-29)28-23(31)27-18-7-3-2-4-8-18/h2-15H,1H3,(H,26,30)(H2,27,28,31) FEENLVZHRIAWGM-UHFFFAOYSA-N 50032817 CHEMBL3355145 Mitogen-activated protein kinase 10 Homo sapiens 115 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032817&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118720654 312528604 CHEMBL3355145 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248222 CN(C)CCn1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C24H25ClN8O2/c1-31(2)10-11-32-15-18(13-26-32)28-23(34)17-6-5-7-20(12-17)33-16-19(14-27-33)29-24(35)30-22-9-4-3-8-21(22)25/h3-9,12-16H,10-11H2,1-2H3,(H,28,34)(H2,29,30,35) JGHISYSDWKNXIA-UHFFFAOYSA-N 50032818 CHEMBL3352845 Mitogen-activated protein kinase 10 Homo sapiens 34 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032818&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146805 312528605 CHEMBL3352845 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248223 CCN(CC)CCn1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C26H29ClN8O2/c1-3-33(4-2)12-13-34-17-20(15-28-34)30-25(36)19-8-7-9-22(14-19)35-18-21(16-29-35)31-26(37)32-24-11-6-5-10-23(24)27/h5-11,14-18H,3-4,12-13H2,1-2H3,(H,30,36)(H2,31,32,37) RNCWDFDHRZZNLS-UHFFFAOYSA-N 50032819 CHEMBL3355175 Mitogen-activated protein kinase 10 Homo sapiens 21 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032819&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146979 312528606 CHEMBL3355175 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248225 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)Nc1cnn(CCN2CCCC2)c1 InChI=1S/C26H27ClN8O2/c27-23-8-1-2-9-24(23)32-26(37)31-21-16-29-35(18-21)22-7-5-6-19(14-22)25(36)30-20-15-28-34(17-20)13-12-33-10-3-4-11-33/h1-2,5-9,14-18H,3-4,10-13H2,(H,30,36)(H2,31,32,37) GRSJRAKNDSATJE-UHFFFAOYSA-N 50032820 CHEMBL3355176 Mitogen-activated protein kinase 10 Homo sapiens 23 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032820&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146804 312528607 CHEMBL3355176 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248228 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)Nc1cnn(c1)C1CCNCC1 InChI=1S/C25H25ClN8O2/c26-22-6-1-2-7-23(22)32-25(36)31-19-14-29-34(16-19)21-5-3-4-17(12-21)24(35)30-18-13-28-33(15-18)20-8-10-27-11-9-20/h1-7,12-16,20,27H,8-11H2,(H,30,35)(H2,31,32,36) ILUOKEKSMZBBQY-UHFFFAOYSA-N 50032749 CHEMBL3355177 Mitogen-activated protein kinase 10 Homo sapiens 23 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032749&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146882 103941204 CHEMBL3355177 ZINC36349932 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248229 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)Nc1cnn(c1)C1CCNC1 InChI=1S/C24H23ClN8O2/c25-21-6-1-2-7-22(21)31-24(35)30-18-12-27-32(15-18)19-5-3-4-16(10-19)23(34)29-17-11-28-33(14-17)20-8-9-26-13-20/h1-7,10-12,14-15,20,26H,8-9,13H2,(H,29,34)(H2,30,31,35) IMARJVJNXLXPIX-UHFFFAOYSA-N 50032821 CHEMBL3355178 Mitogen-activated protein kinase 10 Homo sapiens <1.000000 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032821&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3NL 4WHZ 101891709 312528608 CHEMBL3355178 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248230 CCN(CC)CCNC(=O)c1cccc(c1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C23H27ClN6O2/c1-3-29(4-2)13-12-25-22(31)17-8-7-9-19(14-17)30-16-18(15-26-30)27-23(32)28-21-11-6-5-10-20(21)24/h5-11,14-16H,3-4,12-13H2,1-2H3,(H,25,31)(H2,27,28,32) WPHKXBQJXHEIBX-UHFFFAOYSA-N 50032822 CHEMBL3355179 Mitogen-activated protein kinase 10 Homo sapiens 137 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032822&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118720657 312528609 CHEMBL3355179 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248231 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)NCCCN1CCCC1 InChI=1S/C24H27ClN6O2/c25-21-9-1-2-10-22(21)29-24(33)28-19-16-27-31(17-19)20-8-5-7-18(15-20)23(32)26-11-6-14-30-12-3-4-13-30/h1-2,5,7-10,15-17H,3-4,6,11-14H2,(H,26,32)(H2,28,29,33) AEIFWDBNYVIAIQ-UHFFFAOYSA-N 50032823 CHEMBL3355180 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032823&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146813 312528610 CHEMBL3355180 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248232 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)NCC1CCNCC1 InChI=1S/C23H25ClN6O2/c24-20-6-1-2-7-21(20)29-23(32)28-18-14-27-30(15-18)19-5-3-4-17(12-19)22(31)26-13-16-8-10-25-11-9-16/h1-7,12,14-16,25H,8-11,13H2,(H,26,31)(H2,28,29,32) XDNOBDTYZKRSTK-UHFFFAOYSA-N 50032750 CHEMBL3355181 Mitogen-activated protein kinase 10 Homo sapiens 206 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032750&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 86763302 103941205 CHEMBL3355181 ZINC13742728 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248243 CN1CCC(CNC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)CC1 InChI=1S/C24H27ClN6O2/c1-30-11-9-17(10-12-30)14-26-23(32)18-5-4-6-20(13-18)31-16-19(15-27-31)28-24(33)29-22-8-3-2-7-21(22)25/h2-8,13,15-17H,9-12,14H2,1H3,(H,26,32)(H2,28,29,33) QPRPISWDHJGCPZ-UHFFFAOYSA-N 50032824 CHEMBL3355182 Mitogen-activated protein kinase 10 Homo sapiens 169 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032824&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118144380 312528611 CHEMBL3355182 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248245 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)NC1CNC1 InChI=1S/C20H19ClN6O2/c21-17-6-1-2-7-18(17)26-20(29)25-15-11-23-27(12-15)16-5-3-4-13(8-16)19(28)24-14-9-22-10-14/h1-8,11-12,14,22H,9-10H2,(H,24,28)(H2,25,26,29) SADIOHYAMYOCER-UHFFFAOYSA-N 50032825 CHEMBL3355183 Mitogen-activated protein kinase 10 Homo sapiens 34 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032825&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118720658 312528612 CHEMBL3355183 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50248247 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)NC1CCNC1 InChI=1S/C21H21ClN6O2/c22-18-6-1-2-7-19(18)27-21(30)26-16-12-24-28(13-16)17-5-3-4-14(10-17)20(29)25-15-8-9-23-11-15/h1-7,10,12-13,15,23H,8-9,11H2,(H,25,29)(H2,26,27,30) QEDOJEYFKHMOIX-UHFFFAOYSA-N 50032826 CHEMBL3355184 Mitogen-activated protein kinase 10 Homo sapiens 29 ChEMBL 10.1021/jm501256y 10.7270/Q25140TS 25393557 Zheng, K; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032826&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118720659 312528613 CHEMBL3355184 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265038 N[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-c1cccnc1Oc1ccc(NS(=O)(=O)c2ccccc2Cl)c2ccccc12 InChI=1S/C31H29ClN6O3S/c32-25-9-3-4-10-29(25)42(39,40)38-27-15-16-28(23-7-2-1-6-22(23)27)41-30-24(8-5-18-34-30)26-17-19-35-31(37-26)36-21-13-11-20(33)12-14-21/h1-10,15-21,38H,11-14,33H2,(H,35,36,37)/t20-,21- WZLNUODSHWYWOC-MEMLXQNLSA-N 50043767 CHEMBL3356010 Mitogen-activated protein kinase 10 Homo sapiens 400 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043767&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721245 103975151 CHEMBL3356010 ZINC95609706 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265039 Cc1ccc2c(NS(=O)(=O)c3ccccc3Cl)cccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1 InChI=1S/C31H29ClN6O3S/c1-20-13-14-22-23(8-4-11-27(22)38-42(39,40)28-12-3-2-10-25(28)32)29(20)41-30-24(9-6-17-34-30)26-15-18-35-31(37-26)36-21-7-5-16-33-19-21/h2-4,6,8-15,17-18,21,33,38H,5,7,16,19H2,1H3,(H,35,36,37)/t21-/m0/s1 XMWUCMFVDXDRDE-NRFANRHFSA-N 50043766 CHEMBL3356009 Mitogen-activated protein kinase 10 Homo sapiens 2500 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043766&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search QFV 6URC 118721244 103975150 CHEMBL3356009 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265040 Cc1ccc2c(NS(=O)(=O)c3ccccc3Cl)cccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 InChI=1S/C32H31ClN6O3S/c1-20-11-16-23-24(6-4-9-28(23)39-43(40,41)29-10-3-2-8-26(29)33)30(20)42-31-25(7-5-18-35-31)27-17-19-36-32(38-27)37-22-14-12-21(34)13-15-22/h2-11,16-19,21-22,39H,12-15,34H2,1H3,(H,36,37,38)/t21-,22- MXNISZSSQGUZMA-HZCBDIJESA-N 50043726 CHEMBL3356008 Mitogen-activated protein kinase 10 Homo sapiens 540 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043726&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721243 103975110 CHEMBL3356008 ZINC29314254 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265041 Cc1cc(NS(=O)(=O)c2ccccc2Cl)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 InChI=1S/C32H31ClN6O3S/c1-20-19-28(39-43(40,41)29-11-5-4-10-26(29)33)23-7-2-3-8-24(23)30(20)42-31-25(9-6-17-35-31)27-16-18-36-32(38-27)37-22-14-12-21(34)13-15-22/h2-11,16-19,21-22,39H,12-15,34H2,1H3,(H,36,37,38)/t21-,22- VMXTWHCDROGRNY-HZCBDIJESA-N 50043710 CHEMBL3356007 Mitogen-activated protein kinase 10 Homo sapiens 1600 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043710&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3E4 4U6R 78350466 103975094 CHEMBL3356007 ZINC13733460 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265042 Cc1cc(NS(=O)(=O)c2ccccc2C#N)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 InChI=1S/C33H31N7O3S/c1-21-19-29(40-44(41,42)30-11-5-2-7-22(30)20-34)25-8-3-4-9-26(25)31(21)43-32-27(10-6-17-36-32)28-16-18-37-33(39-28)38-24-14-12-23(35)13-15-24/h2-11,16-19,23-24,40H,12-15,35H2,1H3,(H,37,38,39)/t23-,24- BTRREXVQOUTSPK-RQNOJGIXSA-N 50043709 CHEMBL3356006 Mitogen-activated protein kinase 10 Homo sapiens 400 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043709&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721242 103975093 CHEMBL3356006 ZINC13733446 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265043 COc1ccccc1S(=O)(=O)Nc1cc(C)c(Oc2ncccc2-c2ccnc(N[C@H]3CC[C@H](N)CC3)n2)c2ccccc12 InChI=1S/C33H34N6O4S/c1-21-20-28(39-44(40,41)30-12-6-5-11-29(30)42-2)24-8-3-4-9-25(24)31(21)43-32-26(10-7-18-35-32)27-17-19-36-33(38-27)37-23-15-13-22(34)14-16-23/h3-12,17-20,22-23,39H,13-16,34H2,1-2H3,(H,36,37,38)/t22-,23- RYXTYCHSKGEFAV-YHBQERECSA-N 50043708 CHEMBL3356005 Mitogen-activated protein kinase 10 Homo sapiens 1200 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043708&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721241 103975092 CHEMBL3356005 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265044 Cc1cc(NS(=O)(=O)c2ccccc2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 InChI=1S/C32H32N6O3S/c1-21-20-29(38-42(39,40)24-8-3-2-4-9-24)25-10-5-6-11-26(25)30(21)41-31-27(12-7-18-34-31)28-17-19-35-32(37-28)36-23-15-13-22(33)14-16-23/h2-12,17-20,22-23,38H,13-16,33H2,1H3,(H,35,36,37)/t22-,23- RCOILDNJZSSEPU-YHBQERECSA-N 50043707 CHEMBL3356004 Mitogen-activated protein kinase 10 Homo sapiens 2200 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043707&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721240 103975091 CHEMBL3356004 ZINC13733439 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265045 Cc1cc(Nc2nc3ccccc3o2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 InChI=1S/C33H31N7O2/c1-20-19-28(40-33-39-27-10-4-5-11-29(27)41-33)23-7-2-3-8-24(23)30(20)42-31-25(9-6-17-35-31)26-16-18-36-32(38-26)37-22-14-12-21(34)13-15-22/h2-11,16-19,21-22H,12-15,34H2,1H3,(H,39,40)(H,36,37,38)/t21-,22- GISZVPBPRUQLCY-HZCBDIJESA-N 50043706 CHEMBL3356003 Mitogen-activated protein kinase 10 Homo sapiens 7.0 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043706&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721239 103975090 CHEMBL3356003 ZINC13733472 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265046 Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1 InChI=1S/C32H30N8O/c1-20-18-28(40-32-38-26-12-4-5-13-27(26)39-32)22-9-2-3-10-23(22)29(20)41-30-24(11-7-16-34-30)25-14-17-35-31(37-25)36-21-8-6-15-33-19-21/h2-5,7,9-14,16-18,21,33H,6,8,15,19H2,1H3,(H,35,36,37)(H2,38,39,40)/t21-/m0/s1 UMVDHPFXGXTJAT-NRFANRHFSA-N 50043705 CHEMBL3356002 Mitogen-activated protein kinase 10 Homo sapiens 20 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043705&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721238 103975089 CHEMBL3356002 ZINC13733451 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265047 Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CC[C@H](N)CC2)n1 InChI=1S/C33H32N8O/c1-20-19-29(41-33-39-27-10-4-5-11-28(27)40-33)23-7-2-3-8-24(23)30(20)42-31-25(9-6-17-35-31)26-16-18-36-32(38-26)37-22-14-12-21(34)13-15-22/h2-11,16-19,21-22H,12-15,34H2,1H3,(H,36,37,38)(H2,39,40,41)/t21-,22- FCGYOUSOTWCHEF-HZCBDIJESA-N 50043704 CHEMBL3356001 Mitogen-activated protein kinase 10 Homo sapiens 1.9 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043704&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721237 103975088 CHEMBL3356001 ZINC13733457 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265048 N[C@H]1CC[C@H](CC1)Nc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12 InChI=1S/C32H30N8O/c33-20-11-13-21(14-12-20)36-31-35-19-17-26(37-31)24-8-5-18-34-30(24)41-29-16-15-25(22-6-1-2-7-23(22)29)38-32-39-27-9-3-4-10-28(27)40-32/h1-10,15-21H,11-14,33H2,(H,35,36,37)(H2,38,39,40)/t20-,21+ ZADRUEBKBUVLOM-OYRHEFFESA-N 50043703 CHEMBL3356000 Mitogen-activated protein kinase 10 Homo sapiens 7.5 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043703&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721236 103975087 CHEMBL3356000 ZINC13733482 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265049 N[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12 InChI=1S/C32H30N8O/c33-20-11-13-21(14-12-20)36-31-35-19-17-26(37-31)24-8-5-18-34-30(24)41-29-16-15-25(22-6-1-2-7-23(22)29)38-32-39-27-9-3-4-10-28(27)40-32/h1-10,15-21H,11-14,33H2,(H,35,36,37)(H2,38,39,40)/t20-,21- ZADRUEBKBUVLOM-MEMLXQNLSA-N 50043768 CHEMBL3355999 Mitogen-activated protein kinase 10 Homo sapiens 1.9 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043768&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721236 103975152 CHEMBL3355999 ZINC26168183 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265050 C1CNC[C@H](C1)Nc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12 InChI=1S/C31H28N8O/c1-2-9-22-21(8-1)24(37-31-38-26-11-3-4-12-27(26)39-31)13-14-28(22)40-29-23(10-6-17-33-29)25-15-18-34-30(36-25)35-20-7-5-16-32-19-20/h1-4,6,8-15,17-18,20,32H,5,7,16,19H2,(H,34,35,36)(H2,37,38,39)/t20-/m0/s1 DSBYFQXQZZQAFZ-FQEVSTJZSA-N 50043769 CHEMBL3355998 Mitogen-activated protein kinase 10 Homo sapiens 31 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043769&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721235 103975153 CHEMBL3355998 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265051 C1CNC[C@@H](C1)Nc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12 InChI=1S/C31H28N8O/c1-2-9-22-21(8-1)24(37-31-38-26-11-3-4-12-27(26)39-31)13-14-28(22)40-29-23(10-6-17-33-29)25-15-18-34-30(36-25)35-20-7-5-16-32-19-20/h1-4,6,8-15,17-18,20,32H,5,7,16,19H2,(H,34,35,36)(H2,37,38,39)/t20-/m1/s1 DSBYFQXQZZQAFZ-HXUWFJFHSA-N 50043770 CHEMBL3355997 Mitogen-activated protein kinase 10 Homo sapiens 14 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043770&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721234 103975154 CHEMBL3355997 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265052 CN1CCCC(C1)Nc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12 InChI=1S/C32H30N8O/c1-40-19-7-8-21(20-40)35-31-34-18-16-26(36-31)24-11-6-17-33-30(24)41-29-15-14-25(22-9-2-3-10-23(22)29)37-32-38-27-12-4-5-13-28(27)39-32/h2-6,9-18,21H,7-8,19-20H2,1H3,(H,34,35,36)(H2,37,38,39) NPDBZGWDNRJYIQ-UHFFFAOYSA-N 50043771 CHEMBL3355996 Mitogen-activated protein kinase 10 Homo sapiens 5.5 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043771&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721233 103975155 CHEMBL3355996 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265053 OCCNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12 InChI=1S/C28H23N7O2/c36-17-16-31-27-30-15-13-22(32-27)20-8-5-14-29-26(20)37-25-12-11-21(18-6-1-2-7-19(18)25)33-28-34-23-9-3-4-10-24(23)35-28/h1-15,36H,16-17H2,(H,30,31,32)(H2,33,34,35) PPQCTKOGJAYJQN-UHFFFAOYSA-N 50043772 CHEMBL3355995 Mitogen-activated protein kinase 10 Homo sapiens 12 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043772&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721232 103975156 CHEMBL3355995 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265054 CC(C)CCNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12 InChI=1S/C31H29N7O/c1-20(2)15-18-33-30-34-19-16-25(35-30)23-10-7-17-32-29(23)39-28-14-13-24(21-8-3-4-9-22(21)28)36-31-37-26-11-5-6-12-27(26)38-31/h3-14,16-17,19-20H,15,18H2,1-2H3,(H,33,34,35)(H2,36,37,38) ULRIGDWMHBUIHG-UHFFFAOYSA-N 50043775 CHEMBL3355994 Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043775&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721231 103975159 CHEMBL3355994 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265055 CN(C)CCNc1nccc(n1)-c1cccnc1Oc1c(C)cc(Nc2nc3ccccc3[nH]2)c2ccccc12 InChI=1S/C31H30N8O/c1-20-19-27(38-31-36-25-12-6-7-13-26(25)37-31)21-9-4-5-10-22(21)28(20)40-29-23(11-8-15-32-29)24-14-16-33-30(35-24)34-17-18-39(2)3/h4-16,19H,17-18H2,1-3H3,(H,33,34,35)(H2,36,37,38) MZOBZDVFDCQUAV-UHFFFAOYSA-N 50043776 CHEMBL3355993 Mitogen-activated protein kinase 10 Homo sapiens 710 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043776&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721230 103975160 CHEMBL3355993 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50265056 CN(C)CCNc1nccc(n1)-c1cccnc1Oc1ccc(Nc2nc3ccccc3[nH]2)c2ccccc12 InChI=1S/C30H28N8O/c1-38(2)19-18-33-29-32-17-15-24(34-29)22-10-7-16-31-28(22)39-27-14-13-23(20-8-3-4-9-21(20)27)35-30-36-25-11-5-6-12-26(25)37-30/h3-17H,18-19H2,1-2H3,(H,32,33,34)(H2,35,36,37) IUDPPAXWQBHYHO-UHFFFAOYSA-N 50043777 CHEMBL3355992 Mitogen-activated protein kinase 10 Homo sapiens 350 ChEMBL 10.1021/ml500315b 10.7270/Q2DF6STC 25589933 Harrington, PE; Biswas, K; Malwitz, D; Tasker, AS; Mohr, C; Andrews, KL; Dellamaggiore, K; Kendall, R; Beckmann, H; Jaeckel, P; Materna-Reichelt, S; Allen, JR; Lipford, JR Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50043777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50043777&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118721229 103975161 CHEMBL3355992 ZINC95536588 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50269867 Nc1onc(c1-c1ccncn1)-c1ccc(F)cc1 InChI=1S/C13H9FN4O/c14-9-3-1-8(2-4-9)12-11(13(15)19-18-12)10-5-6-16-7-17-10/h1-7H,15H2 BKBYSKGMHADPJD-UHFFFAOYSA-N 50046045 CHEMBL3310138 Mitogen-activated protein kinase 10 Homo sapiens 2199 ChEMBL 10.1016/j.bmc.2014.05.045 10.7270/Q2C82BXS 24938496 Hasumi, K; Sato, S; Saito, T; Kato, JY; Shirota, K; Sato, J; Suzuki, H; Ohta, S ASKA Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046045&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57467725 103976916 CHEMBL3310138 ZINC26818311 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50269868 Fc1ccc(cc1)-c1noc(NC(=O)Cc2c(F)cccc2Cl)c1-c1ccncn1 InChI=1S/C21H13ClF2N4O2/c22-15-2-1-3-16(24)14(15)10-18(29)27-21-19(17-8-9-25-11-26-17)20(28-30-21)12-4-6-13(23)7-5-12/h1-9,11H,10H2,(H,27,29) OHMPXDCOVKOOAN-UHFFFAOYSA-N 50046049 CHEMBL3310142 Mitogen-activated protein kinase 10 Homo sapiens 572 ChEMBL 10.1016/j.bmc.2014.05.045 10.7270/Q2C82BXS 24938496 Hasumi, K; Sato, S; Saito, T; Kato, JY; Shirota, K; Sato, J; Suzuki, H; Ohta, S ASKA Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046049&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11626055 103976920 CHEMBL3310142 ZINC26819348 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50291813 FC1(F)CCN(C1)c1cc(cc(Nc2cc(ccn2)C#N)n1)C1CCN(CC1)C1COC1 InChI=1S/C23H26F2N6O/c24-23(25)4-8-31(15-23)22-11-18(17-2-6-30(7-3-17)19-13-32-14-19)10-21(29-22)28-20-9-16(12-26)1-5-27-20/h1,5,9-11,17,19H,2-4,6-8,13-15H2,(H,27,28,29) RHFIAUKMKYHHFA-UHFFFAOYSA-N 50059190 CHEMBL3393333 Mitogen-activated protein kinase 10 Homo sapiens 364 ChEMBL 10.1021/jm5013984 10.7270/Q22J6DJ5 25341110 Patel, S; Cohen, F; Dean, BJ; De La Torre, K; Deshmukh, G; Estrada, AA; Ghosh, AS; Gibbons, P; Gustafson, A; Huestis, MP; Le Pichon, CE; Lin, H; Liu, W; Liu, X; Liu, Y; Ly, CQ; Lyssikatos, JP; Ma, C; Scearce-Levie, K; Shin, YG; Solanoy, H; Stark, KL; Wang, J; Wang, B; Zhao, X; Lewcock, JW; Siu, M Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059190&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 50D 5CEO 72547959 313070495 CHEMBL3393333 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50277927 Cc1cccc(n1)-c1n[nH]cc1-c1ccc2ncccc2n1 InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22) LBPKYPYHDKKRFS-UHFFFAOYSA-N 50151347 2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine::2-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-[1,5]naphthyridine::CHEMBL185238 Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1021/jm0400247 10.7270/Q2VQ325T 15317461 Gellibert, F; Woolven, J; Fouchet, MH; Mathews, N; Goodland, H; Lovegrove, V; Laroze, A; Nguyen, VL; Sautet, S; Wang, R; Janson, C; Smith, W; Krysa, G; Boullay, V; De Gouville, AC; Huet, S; Hartley, D GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50151347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50151347&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 449054 104039525 CHEMBL185238 ZINC16052804 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50290990 Clc1ccc(cc1)C(=O)NCc1ccc(s1)S(=O)(=O)N1CCC(CC1)n1nnc2ccccc12 InChI=1S/C23H22ClN5O3S2/c24-17-7-5-16(6-8-17)23(30)25-15-19-9-10-22(33-19)34(31,32)28-13-11-18(12-14-28)29-21-4-2-1-3-20(21)26-27-29/h1-10,18H,11-15H2,(H,25,30) XLVWDHAXEFKTIB-UHFFFAOYSA-N 50158551 CHEMBL383955::N-((5-(4-(1H-benzo[d][1,2,3]triazol-1-yl)piperidin-1-ylsulfonyl)thiophen-2-yl)methyl)-4-chlorobenzamide::N-5-4-1H-benzo[d][1,2,3]triazol-1-yl)piperidin-1-ylsulfonyl)thiophen-2-yl)methyl)-4-chlorobenzamide Mitogen-activated protein kinase 10 Homo sapiens 150 ChEMBL 10.1021/jm031112e 10.7270/Q2XG9QM0 15615541 Ruckle, T; Biamonte, M; Grippi-Vallotton, T; Arkinstall, S; Cambet, Y; Camps, M; Chabert, C; Church, DJ; Halazy, S; Jiang, X; Martinou, I; Nichols, A; Sauer, W; Gotteland, JP Serono Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50158551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50158551&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9892736 104045242 CHEMBL383955 ZINC01493969 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292325 NC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCOCC2)ncc1Cl InChI=1S/C21H21ClN6O2/c22-17-13-24-21(27-20(17)26-18-4-2-1-3-16(18)19(23)29)25-14-5-7-15(8-6-14)28-9-11-30-12-10-28/h1-8,13H,9-12H2,(H2,23,29)(H2,24,25,26,27) NRYVQEKXEUGDJJ-UHFFFAOYSA-N 50059649 CHEMBL3220493 Mitogen-activated protein kinase 10 Homo sapiens 0.300000 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059649&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 90667135 103955446 CHEMBL3220493 ZINC13606243 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292326 COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2C(N)=O)n1)N1CCOCC1 InChI=1S/C22H23ClN6O3/c1-31-19-12-14(29-8-10-32-11-9-29)6-7-18(19)27-22-25-13-16(23)21(28-22)26-17-5-3-2-4-15(17)20(24)30/h2-7,12-13H,8-11H2,1H3,(H2,24,30)(H2,25,26,27,28) IFVVYANOPWLAHG-UHFFFAOYSA-N 50059650 CHEMBL3220495 Mitogen-activated protein kinase 10 Homo sapiens 0.800000 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059650&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 90667137 103955447 CHEMBL3220495 ZINC13606239 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292327 NC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCCC2=O)ncc1Cl InChI=1S/C21H19ClN6O2/c22-16-12-24-21(27-20(16)26-17-5-2-1-4-15(17)19(23)30)25-13-7-9-14(10-8-13)28-11-3-6-18(28)29/h1-2,4-5,7-10,12H,3,6,11H2,(H2,23,30)(H2,24,25,26,27) DXAACKOYNNQYHC-UHFFFAOYSA-N 50059652 CHEMBL3220502 Mitogen-activated protein kinase 10 Homo sapiens 0.160000 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059652&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 90667145 103955449 CHEMBL3220502 ZINC13606237 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292333 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-22-12-10-20(11-13-22)27(37)32-23-7-3-8-24(18-23)33-28-30-16-14-25(34-28)21-6-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ VZEONOGFXYTZGT-WEVVVXLNSA-N 86627 JNK-IN-2 Mitogen-activated protein kinase 10 Homo sapiens 709 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340680 136352676 ZINC89464829 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292339 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1 InChI=1S/C29H29N7O2/c1-20-8-11-24(18-26(20)35-29-31-16-14-25(34-29)22-6-4-15-30-19-22)33-28(38)21-9-12-23(13-10-21)32-27(37)7-5-17-36(2)3/h4-16,18-19H,17H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b7-5+ YFRXAAWSVLQGDR-FNORWQNLSA-N 86626 JNK-IN-1 Mitogen-activated protein kinase 10 Homo sapiens 7750 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25123232 136352675 ZINC87723487 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292345 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ RADRIIWGHYFWPP-WEVVVXLNSA-N 86632 JNK-IN-7 Mitogen-activated protein kinase 10 Homo sapiens 0.700000 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340685 136352681 ZINC87723492 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292346 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1 InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ GJFCSAPFHAXMSF-UXBLZVDNSA-N 86633 JNK-IN-8 Mitogen-activated protein kinase 10 Homo sapiens 1.000000 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340686 136352682 ZINC89464842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292347 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2c(nn3ccccc23)-c2ccccc2)cc1 InChI=1S/C36H32N8O2/c1-43(2)22-9-15-32(45)38-29-13-8-12-26(24-29)35(46)39-27-16-18-28(19-17-27)40-36-37-21-20-30(41-36)33-31-14-6-7-23-44(31)42-34(33)25-10-4-3-5-11-25/h3-21,23-24H,22H2,1-2H3,(H,38,45)(H,39,46)(H,37,40,41)/b15-9+ OCZDPFMSAKKNRH-OQLLNIDSSA-N 86636 JNK-IN-11 Mitogen-activated protein kinase 10 Homo sapiens 0.500000 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340689 136352685 ZINC89464853 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292350 O\N=C1\c2ccccc2-c2nc3ccccc3nc12 InChI=1S/C15H9N3O/c19-18-14-10-6-2-1-5-9(10)13-15(14)17-12-8-4-3-7-11(12)16-13/h1-8,19H/b18-14- SZHHSFHOIDCNLD-JXAWBTAJSA-N 50059656 CHEMBL3393601 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059656&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 619002 313070568 CHEMBL3393601 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292359 O=C(O\N=C1\c2ccccc2-c2nc3ccccc3nc12)c1ccco1 InChI=1S/C20H11N3O3/c24-20(16-10-5-11-25-16)26-23-18-13-7-2-1-6-12(13)17-19(18)22-15-9-4-3-8-14(15)21-17/h1-11H/b23-18- WBSWWONMTZEOGS-NKFKGCMQSA-N 50059657 CHEMBL3393602 Mitogen-activated protein kinase 10 Homo sapiens 66 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059657&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 6877540 313070569 CHEMBL3393602 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292365 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-22-12-10-20(11-13-22)27(37)32-23-7-3-8-24(18-23)33-28-30-16-14-25(34-28)21-6-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ VZEONOGFXYTZGT-WEVVVXLNSA-N 86627 JNK-IN-2 Mitogen-activated protein kinase 10 Homo sapiens 704 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340680 136352676 ZINC89464829 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292372 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ RADRIIWGHYFWPP-WEVVVXLNSA-N 86632 JNK-IN-7 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340685 136352681 ZINC87723492 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292373 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1 InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ GJFCSAPFHAXMSF-UXBLZVDNSA-N 86633 JNK-IN-8 Mitogen-activated protein kinase 10 Homo sapiens 486 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340686 136352682 ZINC89464842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292374 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2c(nn3ccccc23)-c2ccccc2)cc1 InChI=1S/C36H32N8O2/c1-43(2)22-9-15-32(45)38-29-13-8-12-26(24-29)35(46)39-27-16-18-28(19-17-27)40-36-37-21-20-30(41-36)33-31-14-6-7-23-44(31)42-34(33)25-10-4-3-5-11-25/h3-21,23-24H,22H2,1-2H3,(H,38,45)(H,39,46)(H,37,40,41)/b15-9+ OCZDPFMSAKKNRH-OQLLNIDSSA-N 86636 JNK-IN-11 Mitogen-activated protein kinase 10 Homo sapiens 48 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340689 136352685 ZINC89464853 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292382 COc1ccc2OC(COc2c1)C(=O)NC(=O)N(CC(C)C)CC(=O)NCCCCCCNC(=O)c1ccc(cc1)-c1n[nH]c2ccccc12 50059659 CHEMBL3393604 Mitogen-activated protein kinase 10 Homo sapiens 12 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059659&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725554 313070571 CHEMBL3393604 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292384 Fc1cc(cc(c1)-c1ccnc(Nc2ccc(cc2)-n2cnc(n2)N2CCOCC2)n1)N1CCOCC1 InChI=1S/C26H27FN8O2/c27-20-15-19(16-23(17-20)33-7-11-36-12-8-33)24-5-6-28-25(31-24)30-21-1-3-22(4-2-21)35-18-29-26(32-35)34-9-13-37-14-10-34/h1-6,15-18H,7-14H2,(H,28,30,31) AHMHIFXJPSHHPH-UHFFFAOYSA-N 50303646 4-(3-Fluoro-5-morpholinophenyl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine::CHEMBL585951::N-[(2Z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1H)-ylidene]-4-(3-morpholin-4-yl-1H-1,2,4-triazol-1-yl)aniline Mitogen-activated protein kinase 10 Homo sapiens 148 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303646&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25222038 104158007 CHEMBL585951 ZINC44460355 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292385 Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cccc(c2)N2CCOCC2)cc1 InChI=1S/C28H26N8O/c1-20-5-6-22(18-30-20)27-31-19-36(34-27)24-9-7-23(8-10-24)32-28-29-12-11-26(33-28)21-3-2-4-25(17-21)35-13-15-37-16-14-35/h2-12,17-19H,13-16H2,1H3,(H,29,32,33) QDMXVKKPYBGIAS-UHFFFAOYSA-N 50059654 CHEMBL2144409 Mitogen-activated protein kinase 10 Homo sapiens 159 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059654&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57519510 313070566 CHEMBL2144409 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292390 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-22-12-10-20(11-13-22)27(37)32-23-7-3-8-24(18-23)33-28-30-16-14-25(34-28)21-6-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ VZEONOGFXYTZGT-WEVVVXLNSA-N 86627 JNK-IN-2 Mitogen-activated protein kinase 10 Homo sapiens 2400 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340680 136352676 ZINC89464829 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292391 CNC(=O)c1ccccc1Nc1cc(Nc2ccc(cc2OC)N2CCOCC2)ncc1Cl InChI=1S/C24H26ClN5O3/c1-26-24(31)17-5-3-4-6-19(17)28-21-14-23(27-15-18(21)25)29-20-8-7-16(13-22(20)32-2)30-9-11-33-12-10-30/h3-8,13-15H,9-12H2,1-2H3,(H,26,31)(H2,27,28,29) SVIILPGBQTUQPJ-UHFFFAOYSA-N 50059658 CHEMBL3220466 Mitogen-activated protein kinase 10 Homo sapiens 83 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059658&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44200209 313070570 CHEMBL3220466 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292392 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ RADRIIWGHYFWPP-WEVVVXLNSA-N 86632 JNK-IN-7 Mitogen-activated protein kinase 10 Homo sapiens 244 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340685 136352681 ZINC87723492 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292393 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1 InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ GJFCSAPFHAXMSF-UXBLZVDNSA-N 86633 JNK-IN-8 Mitogen-activated protein kinase 10 Homo sapiens 338 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340686 136352682 ZINC89464842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292399 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2c(nn3ccccc23)-c2ccccc2)cc1 InChI=1S/C36H32N8O2/c1-43(2)22-9-15-32(45)38-29-13-8-12-26(24-29)35(46)39-27-16-18-28(19-17-27)40-36-37-21-20-30(41-36)33-31-14-6-7-23-44(31)42-34(33)25-10-4-3-5-11-25/h3-21,23-24H,22H2,1-2H3,(H,38,45)(H,39,46)(H,37,40,41)/b15-9+ OCZDPFMSAKKNRH-OQLLNIDSSA-N 86636 JNK-IN-11 Mitogen-activated protein kinase 10 Homo sapiens 9.0 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340689 136352685 ZINC89464853 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292403 COc1ccc(cc1OC)C(=O)O\N=C1\c2ccccc2-c2nc3ccccc3nc12 InChI=1S/C24H17N3O4/c1-29-19-12-11-14(13-20(19)30-2)24(28)31-27-22-16-8-4-3-7-15(16)21-23(22)26-18-10-6-5-9-17(18)25-21/h3-13H,1-2H3/b27-22- VMVANPCSWYULOT-QYQHSDTDSA-N 50059655 CHEMBL3393603 Mitogen-activated protein kinase 10 Homo sapiens 64 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059655&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5436358 313070567 CHEMBL3393603 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292435 Oc1c2cccc3N=Nc(c23)c2ccccc12 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,17H KRIUNPBAQZGFQA-UHFFFAOYSA-N 50024294 SP-600125 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50024294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50024294&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 8515 277286496 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292436 CN(C)c1ccc(cc1)-c1cnc2[nH]cc(-c3cn[nH]c3)c2c1 InChI=1S/C18H17N5/c1-23(2)15-5-3-12(4-6-15)13-7-16-17(14-9-21-22-10-14)11-20-18(16)19-8-13/h3-11H,1-2H3,(H,19,20)(H,21,22) IPPNJZWFNCNYSG-UHFFFAOYSA-N 50059661 CHEMBL3393595 Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059661&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10040667 313070573 CHEMBL3393595 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292437 Cn1cc(cn1)-c1c[nH]c2ncc(cc12)[C@H]1CC[C@@H](CC1)N1CCOCC1 50059662 CHEMBL3393596 Mitogen-activated protein kinase 10 Homo sapiens 85 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059662&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24875373 313070574 CHEMBL3393596 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292438 Cn1cc(cn1)-c1c[nH]c2ncc(cc12)[C@H]1CC[C@@H](CC1)N1CCCOCC1 50059663 CHEMBL3393597 Mitogen-activated protein kinase 10 Homo sapiens 129 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059663&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25024184 313070575 CHEMBL3393597 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292439 COc1cc(NC(=O)c2cccc(c2)-n2ncc3cc(Nc4ccccc4F)ccc23)cc(OC)c1OC InChI=1S/C29H25FN4O4/c1-36-26-15-21(16-27(37-2)28(26)38-3)33-29(35)18-7-6-8-22(14-18)34-25-12-11-20(13-19(25)17-31-34)32-24-10-5-4-9-23(24)30/h4-17,32H,1-3H3,(H,33,35) GYQLVKWGHKBDMP-UHFFFAOYSA-N 50059660 CHEMBL1233748 Mitogen-activated protein kinase 10 Homo sapiens 9.0 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059660&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JK2 3FI3 25174103 313070572 CHEMBL1233748 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292440 Clc1ccccc1Nc1ccc2n(ncc2c1)-c1cc(ccn1)C(=O)NCCN1CCOCC1 InChI=1S/C25H25ClN6O2/c26-21-3-1-2-4-22(21)30-20-5-6-23-19(15-20)17-29-32(23)24-16-18(7-8-27-24)25(33)28-9-10-31-11-13-34-14-12-31/h1-8,15-17,30H,9-14H2,(H,28,33) JAQYMLHJXIRKSU-UHFFFAOYSA-N 50433093 CHEMBL2376930 Mitogen-activated protein kinase 10 Homo sapiens 120 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433093&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71602867 175445410 CHEMBL2376930 ZINC96258414 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292441 Clc1ccccc1Nc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)NCCN1CCN(CC1)C1CCC1 InChI=1S/C30H33ClN6O/c31-27-9-1-2-10-28(27)34-24-11-12-29-23(19-24)21-33-37(29)26-8-3-5-22(20-26)30(38)32-13-14-35-15-17-36(18-16-35)25-6-4-7-25/h1-3,5,8-12,19-21,25,34H,4,6-7,13-18H2,(H,32,38) JNEVMXDLGBKOSK-UHFFFAOYSA-N 50059664 CHEMBL3393598 Mitogen-activated protein kinase 10 Homo sapiens 40 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059664&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725553 313070576 CHEMBL3393598 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292442 COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3cccc(C)c3)cn2)cc(OC)c1OC InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34) MTFAYLZZDJGFGV-UHFFFAOYSA-N 92524 Aminopyrazole inhibitor, 3576 Mitogen-activated protein kinase 10 Homo sapiens 7.0 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92524&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70702008 160845021 ZINC71773480 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292443 COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3)cn2)cc(OC)c1OC InChI=1S/C26H25N5O5/c1-34-22-13-19(14-23(35-2)24(22)36-3)28-25(32)17-8-7-11-21(12-17)31-16-20(15-27-31)30-26(33)29-18-9-5-4-6-10-18/h4-16H,1-3H3,(H,28,32)(H2,29,30,33) RQEFLPVRZJPIAZ-UHFFFAOYSA-N 92522 Aminopyrazole inhibitor, 3451 Mitogen-activated protein kinase 10 Homo sapiens 25 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=92522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=92522&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JK1 3FI2 49867175 160845019 ZINC39232470 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292444 NC(=O)c1ccc(Nc2nccc(n2)-c2ccccc2)cc1 InChI=1S/C17H14N4O/c18-16(22)13-6-8-14(9-7-13)20-17-19-11-10-15(21-17)12-4-2-1-3-5-12/h1-11H,(H2,18,22)(H,19,20,21) NEBNIXUGANAKDR-UHFFFAOYSA-N 50303636 4-(4-Phenylpyrimidin-2-ylamino)benzamide::CHEMBL571619 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627578 104157997 CHEMBL571619 ZINC45286250 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50292445 CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)-n2ccnn2)n1 InChI=1S/C19H17N7O2S/c1-29(27,28)24-16-4-2-14(3-5-16)18-10-11-20-19(23-18)22-15-6-8-17(9-7-15)26-13-12-21-25-26/h2-13,24H,1H3,(H,20,22,23) MDCMULVKRBERMG-UHFFFAOYSA-N 50303639 CHEMBL571626::N-(4-(2-(4-(1H-1,2,3-Triazol-1-yl)phenylamino)pyrimidin-4-yl)-phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 4.0 ChEMBL 10.1021/jm501212r 10.7270/Q2JH3NVZ 25415535 Koch, P; Gehringer, M; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303639&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627582 104158000 CHEMBL571626 ZINC45286868 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304586 Cc1noc(n1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H21F2N7O/c1-10-28-22(32-31-10)17-11-2-4-12(5-3-11)18(17)29-21-16(24)9-27-20(30-21)15-8-26-19-14(15)6-13(23)7-25-19/h6-9,11-12,17-18H,2-5H2,1H3,(H,25,26)(H,27,29,30)/t11?,12?,17-,18-/m0/s1 IYFIEJRWVMLGOG-DFYNNNJYSA-N 50067538 CHEMBL3401988 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067538&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728824 103961977 CHEMBL3401988 ZINC27430272 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304587 CC(O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H23F2N5O/c1-10(29)17-11-2-4-12(5-3-11)18(17)27-21-16(23)9-26-20(28-21)15-8-25-19-14(15)6-13(22)7-24-19/h6-12,17-18,29H,2-5H2,1H3,(H,24,25)(H,26,27,28)/t10?,11?,12?,17-,18-/m0/s1 UVHNIMCYDWMRAE-LOTSEXGMSA-N 50067537 CHEMBL3401987 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067537&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728823 103961976 CHEMBL3401987 ZINC27424532 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304588 CNC(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H22F2N6O/c1-24-21(30)16-10-2-4-11(5-3-10)17(16)28-20-15(23)9-27-19(29-20)14-8-26-18-13(14)6-12(22)7-25-18/h6-11,16-17H,2-5H2,1H3,(H,24,30)(H,25,26)(H,27,28,29)/t10?,11?,16-,17-/m0/s1 FQAOJJZIGINGIO-VOGSPBGVSA-N 50067535 CHEMBL3401986 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067535&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728822 103961974 CHEMBL3401986 ZINC03781115 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304589 Oc1cc([nH]n1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H21F2N7O/c23-12-5-13-14(8-26-20(13)25-7-12)21-27-9-15(24)22(29-21)28-19-11-3-1-10(2-4-11)18(19)16-6-17(32)31-30-16/h5-11,18-19H,1-4H2,(H,25,26)(H,27,28,29)(H2,30,31,32)/t10?,11?,18-,19+/m1/s1 NHGXNIGDTNEHGJ-DJZCKWSOSA-N 50067534 CHEMBL3401985 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067534&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728821 103961973 CHEMBL3401985 ZINC13781583 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304590 CS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C20H21F2N5O2S/c1-30(28,29)17-11-4-2-10(3-5-11)16(17)26-20-15(22)9-25-19(27-20)14-8-24-18-13(14)6-12(21)7-23-18/h6-11,16-17H,2-5H2,1H3,(H,23,24)(H,25,26,27)/t10?,11?,16-,17-/m0/s1 PMGPBZHUTBKGCZ-VOGSPBGVSA-N 50067540 CHEMBL3401990 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067540&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728826 103961979 CHEMBL3401990 ZINC27432272 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304591 Cc1nnc(o1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H21F2N7O/c1-10-30-31-22(32-10)17-11-2-4-12(5-3-11)18(17)28-21-16(24)9-27-20(29-21)15-8-26-19-14(15)6-13(23)7-25-19/h6-9,11-12,17-18H,2-5H2,1H3,(H,25,26)(H,27,28,29)/t11?,12?,17-,18-/m0/s1 WIMOLDAKNKMBFB-DFYNNNJYSA-N 50067539 CHEMBL3401989 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067539&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728825 103961978 CHEMBL3401989 ZINC27427996 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304592 OCC(O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H23F2N5O2/c22-12-5-13-14(7-25-19(13)24-6-12)20-26-8-15(23)21(28-20)27-18-11-3-1-10(2-4-11)17(18)16(30)9-29/h5-8,10-11,16-18,29-30H,1-4,9H2,(H,24,25)(H,26,27,28)/t10?,11?,16?,17-,18+/m1/s1 VAPOMSIOLKMAIW-DBPFDUESSA-N 50067533 CHEMBL3401984 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728820 103961972 CHEMBL3401984 ZINC13781582 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304594 OP(O)(=O)CC[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H24F2N5O3P/c22-13-7-15-16(9-25-19(15)24-8-13)20-26-10-17(23)21(28-20)27-18-12-3-1-11(2-4-12)14(18)5-6-32(29,30)31/h7-12,14,18H,1-6H2,(H,24,25)(H,26,27,28)(H2,29,30,31)/t11?,12?,14-,18-/m0/s1 YQXSREGMIKNZEU-TZQPCPOVSA-N 50067513 CHEMBL3401977 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067513&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728813 103961952 CHEMBL3401977 ZINC00580262 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304596 OP(O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C19H20F2N5O3P/c20-11-5-12-13(7-23-17(12)22-6-11)18-24-8-14(21)19(26-18)25-15-9-1-3-10(4-2-9)16(15)30(27,28)29/h5-10,15-16H,1-4H2,(H,22,23)(H,24,25,26)(H2,27,28,29)/t9?,10?,15-,16-/m0/s1 UXVRWSBRRRIFQG-SBBZOCNPSA-N 50067542 CHEMBL3401976 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067542&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728812 103961981 CHEMBL3401976 ZINC27427032 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304598 Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4C5CCC(CC5)[C@@H]4c4nnn[nH]4)n3)c2c1 InChI=1S/C20H19F2N9/c21-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(22)19(27-18)26-16-10-3-1-9(2-4-10)15(16)20-28-30-31-29-20/h5-10,15-16H,1-4H2,(H,23,24)(H,25,26,27)(H,28,29,30,31)/t9?,10?,15-,16-/m0/s1 GUZDKGKFDUYPQP-SBBZOCNPSA-N 50067541 CHEMBL3401975 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067541&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728811 103961980 CHEMBL3401975 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304600 Oc1cc(on1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H20F2N6O2/c23-12-5-13-14(8-26-20(13)25-7-12)21-27-9-15(24)22(29-21)28-19-11-3-1-10(2-4-11)18(19)16-6-17(31)30-32-16/h5-11,18-19H,1-4H2,(H,25,26)(H,30,31)(H,27,28,29)/t10?,11?,18-,19+/m1/s1 JYDWJFDOWRSYSW-DJZCKWSOSA-N 50067518 CHEMBL3401981 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067518&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728817 103961957 CHEMBL3401981 ZINC00583793 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304602 CC(=O)NS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C21H22F2N6O3S/c1-10(30)29-33(31,32)18-12-4-2-11(3-5-12)17(18)27-21-16(23)9-26-20(28-21)15-8-25-19-14(15)6-13(22)7-24-19/h6-9,11-12,17-18H,2-5H2,1H3,(H,24,25)(H,29,30)(H,26,27,28)/t11?,12?,17-,18-/m0/s1 ACXVCLUGFVYVMQ-DFYNNNJYSA-N 50067517 CHEMBL3401980 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067517&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728816 103961956 CHEMBL3401980 ZINC27417770 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304604 Oc1cc(no1)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C22H20F2N6O2/c23-12-5-13-14(8-26-20(13)25-7-12)21-27-9-15(24)22(29-21)28-19-11-3-1-10(2-4-11)18(19)16-6-17(31)32-30-16/h5-11,18-19,31H,1-4H2,(H,25,26)(H,27,28,29)/t10?,11?,18-,19+/m1/s1 DFYXXJJSVFEUQI-DJZCKWSOSA-N 50067515 CHEMBL3401979 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067515&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728815 103961954 CHEMBL3401979 ZINC01903043 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304606 Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4C5CCC(CC5)[C@@H]4Cn4oc(=O)[nH]c4=O)n3)c2c1 InChI=1S/C22H21F2N7O3/c23-12-5-13-14(7-26-18(13)25-6-12)19-27-8-16(24)20(29-19)28-17-11-3-1-10(2-4-11)15(17)9-31-21(32)30-22(33)34-31/h5-8,10-11,15,17H,1-4,9H2,(H,25,26)(H,27,28,29)(H,30,32,33)/t10?,11?,15-,17-/m0/s1 DMGXNXJIKAWOHP-JJIXEQETSA-N 50067514 CHEMBL3401978 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067514&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728814 103961953 CHEMBL3401978 ZINC13781567 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304616 NS(=O)(=O)[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12 InChI=1S/C19H20F2N6O2S/c20-11-5-12-13(7-24-17(12)23-6-11)18-25-8-14(21)19(27-18)26-15-9-1-3-10(4-2-9)16(15)30(22,28)29/h5-10,15-16H,1-4H2,(H,23,24)(H2,22,28,29)(H,25,26,27)/t9?,10?,15-,16-/m0/s1 BZIKSZZVJAQWMC-SBBZOCNPSA-N 50067531 CHEMBL3401983 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067531&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728819 103961970 CHEMBL3401983 ZINC03791117 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50304617 Fc1cnc2[nH]cc(-c3ncc(F)c(N[C@H]4C5CCC(CC5)[C@@H]4c4nc(=O)o[nH]4)n3)c2c1 InChI=1S/C21H19F2N7O2/c22-11-5-12-13(7-25-17(12)24-6-11)18-26-8-14(23)19(28-18)27-16-10-3-1-9(2-4-10)15(16)20-29-21(31)32-30-20/h5-10,15-16H,1-4H2,(H,24,25)(H,26,27,28)(H,29,30,31)/t9?,10?,15-,16-/m0/s1 YQHXFSMWBWXLGR-SBBZOCNPSA-N 50067520 CHEMBL3401982 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2015.03.013 10.7270/Q2V40WW5 25827523 Boyd, MJ; Bandarage, UK; Bennett, H; Byrn, RR; Davies, I; Gu, W; Jacobs, M; Ledeboer, MW; Ledford, B; Leeman, JR; Perola, E; Wang, T; Bennani, Y; Clark, MP; Charifson, PS Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50067520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50067520&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118728818 103961959 CHEMBL3401982 ZINC01996441 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50296627 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 10 Homo sapiens 45 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50296692 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Mitogen-activated protein kinase 10 Homo sapiens 2300 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50296847 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Mitogen-activated protein kinase 10 Homo sapiens 2800 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50296861 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Mitogen-activated protein kinase 10 Homo sapiens 3300 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search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itogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50296879 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Mitogen-activated protein kinase 10 Homo sapiens 51 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50296902 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 10 Homo sapiens 62 ChEMBL 10.1038/nbt1068 10.7270/Q2V69J3T 15711537 Fabian, MA; Biggs, WH; Treiber, DK; Atteridge, CE; Azimioara, MD; Benedetti, MG; Carter, TA; Ciceri, P; Edeen, PT; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lelias, JM; Mehta, SA; Milanov, ZV; Velasco, AM; Wodicka, LM; Patel, HK; Zarrinkar, PP; Lockhart, DJ Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319931 COc1ccc(COC[C@@H]2CCc3nc(c(-c4ccnc(N)n4)n23)-c2ccc(F)cc2)cc1 InChI=1S/C25H24FN5O2/c1-32-20-9-2-16(3-10-20)14-33-15-19-8-11-22-30-23(17-4-6-18(26)7-5-17)24(31(19)22)21-12-13-28-25(27)29-21/h2-7,9-10,12-13,19H,8,11,14-15H2,1H3,(H2,27,28,29)/t19-/m0/s1 BKLYUVKUMMLBIJ-IBGZPJMESA-N 50173168 4-[(S)-2-(4-Fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-ylamine::CHEMBL372082 Mitogen-activated protein kinase 10 Homo sapiens 61.2 ChEMBL 10.1016/j.bmcl.2005.07.076 10.7270/Q28G8K8K 16153829 Graczyk, PP; Khan, A; Bhatia, GS; Palmer, V; Medland, D; Numata, H; Oinuma, H; Catchick, J; Dunne, A; Ellis, M; Smales, C; Whitfield, J; Neame, SJ; Shah, B; Wilton, D; Morgan, L; Patel, T; Chung, R; Desmond, H; Staddon, JM; Sato, N; Inoue, A University College London http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173168&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10225532 104059139 CHEMBL372082 ZINC28528258 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319933 CCCNc1nccc(n1)-c1c(nc2CC[C@@H](CO)n12)-c1ccc(F)cc1 InChI=1S/C20H22FN5O/c1-2-10-22-20-23-11-9-16(24-20)19-18(13-3-5-14(21)6-4-13)25-17-8-7-15(12-27)26(17)19/h3-6,9,11,15,27H,2,7-8,10,12H2,1H3,(H,22,23,24)/t15-/m0/s1 AMLKAXKHAOGCFY-HNNXBMFYSA-N 50173167 (S)-(2-(4-fluorophenyl)-3-(2-(propylamino)pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl)methanol::CHEMBL198756::[(S)-2-(4-Fluoro-phenyl)-3-(2-propylamino-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]-methanol Mitogen-activated protein kinase 10 Homo sapiens 2.5 ChEMBL 10.1016/j.bmcl.2005.07.076 10.7270/Q28G8K8K 16153829 Graczyk, PP; Khan, A; Bhatia, GS; Palmer, V; Medland, D; Numata, H; Oinuma, H; Catchick, J; Dunne, A; Ellis, M; Smales, C; Whitfield, J; Neame, SJ; Shah, B; Wilton, D; Morgan, L; Patel, T; Chung, R; Desmond, H; Staddon, JM; Sato, N; Inoue, A University College London http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173167&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16007071 104059138 CHEMBL198756 ZINC13985866 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319934 CCCNc1nccc(n1)-c1c(nc2CC[C@H](COCc3ccc(OC)cc3)n12)-c1ccc(F)cc1 InChI=1S/C28H30FN5O2/c1-3-15-30-28-31-16-14-24(32-28)27-26(20-6-8-21(29)9-7-20)33-25-13-10-22(34(25)27)18-36-17-19-4-11-23(35-2)12-5-19/h4-9,11-12,14,16,22H,3,10,13,15,17-18H2,1-2H3,(H,30,31,32)/t22-/m1/s1 HYYRJELYMNIRGB-JOCHJYFZSA-N 50173170 CHEMBL198261::{4-[(R)-2-(4-Fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-yl}-propyl-amine Mitogen-activated protein kinase 10 Homo sapiens 233 ChEMBL 10.1016/j.bmcl.2005.07.076 10.7270/Q28G8K8K 16153829 Graczyk, PP; Khan, A; Bhatia, GS; Palmer, V; Medland, D; Numata, H; Oinuma, H; Catchick, J; Dunne, A; Ellis, M; Smales, C; Whitfield, J; Neame, SJ; Shah, B; Wilton, D; Morgan, L; Patel, T; Chung, R; Desmond, H; Staddon, JM; Sato, N; Inoue, A University College London http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173170&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44404438 104059141 CHEMBL198261 ZINC28528539 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319935 Fc1ccc(cc1)-c1ncn(CCCNC(=O)c2ccccc2)c1-c1ccncc1 InChI=1S/C24H21FN4O/c25-21-9-7-18(8-10-21)22-23(19-11-14-26-15-12-19)29(17-28-22)16-4-13-27-24(30)20-5-2-1-3-6-20/h1-3,5-12,14-15,17H,4,13,16H2,(H,27,30) VLMWLALTUHMVKC-UHFFFAOYSA-N 50173171 CHEMBL199247::N-(3-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-1-yl)propyl)benzamide::N-{3-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-imidazol-1-yl]-propyl}-benzamide Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2005.07.076 10.7270/Q28G8K8K 16153829 Graczyk, PP; Khan, A; Bhatia, GS; Palmer, V; Medland, D; Numata, H; Oinuma, H; Catchick, J; Dunne, A; Ellis, M; Smales, C; Whitfield, J; Neame, SJ; Shah, B; Wilton, D; Morgan, L; Patel, T; Chung, R; Desmond, H; Staddon, JM; Sato, N; Inoue, A University College London http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173171&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44404444 104059142 CHEMBL199247 ZINC28528239 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319938 CCCNc1nccc(n1)-c1c(nc2CC[C@H](CO)n12)-c1ccc(F)cc1 InChI=1S/C20H22FN5O/c1-2-10-22-20-23-11-9-16(24-20)19-18(13-3-5-14(21)6-4-13)25-17-8-7-15(12-27)26(17)19/h3-6,9,11,15,27H,2,7-8,10,12H2,1H3,(H,22,23,24)/t15-/m1/s1 AMLKAXKHAOGCFY-OAHLLOKOSA-N 50173169 CHEMBL383799::[(R)-2-(4-Fluoro-phenyl)-3-(2-propylamino-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]-methanol Mitogen-activated protein kinase 10 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2005.07.076 10.7270/Q28G8K8K 16153829 Graczyk, PP; Khan, A; Bhatia, GS; Palmer, V; Medland, D; Numata, H; Oinuma, H; Catchick, J; Dunne, A; Ellis, M; Smales, C; Whitfield, J; Neame, SJ; Shah, B; Wilton, D; Morgan, L; Patel, T; Chung, R; Desmond, H; Staddon, JM; Sato, N; Inoue, A University College London http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173169&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44404441 104059140 CHEMBL383799 ZINC13985870 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319939 COc1ccc(COC[C@H]2CCc3nc(c(-c4ccnc(N)n4)n23)-c2ccc(F)cc2)cc1 InChI=1S/C25H24FN5O2/c1-32-20-9-2-16(3-10-20)14-33-15-19-8-11-22-30-23(17-4-6-18(26)7-5-17)24(31(19)22)21-12-13-28-25(27)29-21/h2-7,9-10,12-13,19H,8,11,14-15H2,1H3,(H2,27,28,29)/t19-/m1/s1 BKLYUVKUMMLBIJ-LJQANCHMSA-N 50173172 4-[(R)-2-(4-Fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-ylamine::CHEMBL198427 Mitogen-activated protein kinase 10 Homo sapiens 270 ChEMBL 10.1016/j.bmcl.2005.07.076 10.7270/Q28G8K8K 16153829 Graczyk, PP; Khan, A; Bhatia, GS; Palmer, V; Medland, D; Numata, H; Oinuma, H; Catchick, J; Dunne, A; Ellis, M; Smales, C; Whitfield, J; Neame, SJ; Shah, B; Wilton, D; Morgan, L; Patel, T; Chung, R; Desmond, H; Staddon, JM; Sato, N; Inoue, A University College London http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173172&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44404432 104059143 CHEMBL198427 ZINC28528819 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319940 CCCNc1nccc(n1)-c1c(nc2CC[C@@H](COCc3ccc(OC)cc3)n12)-c1ccc(F)cc1 InChI=1S/C28H30FN5O2/c1-3-15-30-28-31-16-14-24(32-28)27-26(20-6-8-21(29)9-7-20)33-25-13-10-22(34(25)27)18-36-17-19-4-11-23(35-2)12-5-19/h4-9,11-12,14,16,22H,3,10,13,15,17-18H2,1-2H3,(H,30,31,32)/t22-/m0/s1 HYYRJELYMNIRGB-QFIPXVFZSA-N 50173173 CHEMBL383348::{4-[(S)-2-(4-Fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-yl}-propyl-amine Mitogen-activated protein kinase 10 Homo sapiens 10.9 ChEMBL 10.1016/j.bmcl.2005.07.076 10.7270/Q28G8K8K 16153829 Graczyk, PP; Khan, A; Bhatia, GS; Palmer, V; Medland, D; Numata, H; Oinuma, H; Catchick, J; Dunne, A; Ellis, M; Smales, C; Whitfield, J; Neame, SJ; Shah, B; Wilton, D; Morgan, L; Patel, T; Chung, R; Desmond, H; Staddon, JM; Sato, N; Inoue, A University College London http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173173&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44404434 104059144 CHEMBL383348 ZINC13985862 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50314024 CC(C)NC(=O)c1cccc(NC(=O)Nc2ccc(cc2)-c2ncnc3[nH]cc(C)c23)c1 InChI=1S/C24H24N6O2/c1-14(2)28-23(31)17-5-4-6-19(11-17)30-24(32)29-18-9-7-16(8-10-18)21-20-15(3)12-25-22(20)27-13-26-21/h4-14H,1-3H3,(H,28,31)(H,25,26,27)(H2,29,30,32) DFFVLCZIIWJVNO-UHFFFAOYSA-N 50364649 CHEMBL1951346 Mitogen-activated protein kinase 10 Homo sapiens 7738 ChEMBL 10.1021/jm501680m 10.7270/Q2K64KRC 25621531 Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50364649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50364649&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57404048 136968711 CHEMBL1951346 ZINC73276965 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50314025 Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccc(F)cc4)cc3)c12 InChI=1S/C22H20FN5O2/c1-14-12-24-21-19(14)20(25-13-26-21)15-2-6-17(7-3-15)27-22(30)28(10-11-29)18-8-4-16(23)5-9-18/h2-9,12-13,29H,10-11H2,1H3,(H,27,30)(H,24,25,26) FCMRBYJIHLJQSI-UHFFFAOYSA-N 50072829 CHEMBL3410039 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm501680m 10.7270/Q2K64KRC 25621531 Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072829&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118732094 313072667 CHEMBL3410039 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50314026 Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccc(Cl)cc4)cc3)c12 InChI=1S/C22H20ClN5O2/c1-14-12-24-21-19(14)20(25-13-26-21)15-2-6-17(7-3-15)27-22(30)28(10-11-29)18-8-4-16(23)5-9-18/h2-9,12-13,29H,10-11H2,1H3,(H,27,30)(H,24,25,26) JCTYQNFVGRNXDM-UHFFFAOYSA-N 50072667 CHEMBL3410042 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm501680m 10.7270/Q2K64KRC 25621531 Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072667&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118732096 103966279 CHEMBL3410042 ZINC26998402 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50314027 Cc1c[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccc(C)cc4)cc3)c12 InChI=1S/C23H23N5O2/c1-15-3-9-19(10-4-15)28(11-12-29)23(30)27-18-7-5-17(6-8-18)21-20-16(2)13-24-22(20)26-14-25-21/h3-10,13-14,29H,11-12H2,1-2H3,(H,27,30)(H,24,25,26) ORBGUTWDZNLYOS-UHFFFAOYSA-N 50072668 CHEMBL3410045 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm501680m 10.7270/Q2K64KRC 25621531 Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072668&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118732099 103966280 CHEMBL3410045 ZINC26988487 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50314028 COc1ccc(cc1)N(CCO)C(=O)Nc1ccc(cc1)-c1ncnc2[nH]cc(C)c12 InChI=1S/C23H23N5O3/c1-15-13-24-22-20(15)21(25-14-26-22)16-3-5-17(6-4-16)27-23(30)28(11-12-29)18-7-9-19(31-2)10-8-18/h3-10,13-14,29H,11-12H2,1-2H3,(H,27,30)(H,24,25,26) AIEHRBYQUAJZPW-UHFFFAOYSA-N 50072669 CHEMBL3410048 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm501680m 10.7270/Q2K64KRC 25621531 Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072669&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118732102 103966281 CHEMBL3410048 ZINC26986842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50314029 Cc1[nH]c2ncnc(-c3ccc(NC(=O)N(CCO)c4ccc(Cl)cc4)c(F)c3)c2c1C InChI=1S/C23H21ClFN5O2/c1-13-14(2)28-22-20(13)21(26-12-27-22)15-3-8-19(18(25)11-15)29-23(32)30(9-10-31)17-6-4-16(24)5-7-17/h3-8,11-12,31H,9-10H2,1-2H3,(H,29,32)(H,26,27,28) MJLIEEBUGOUWCS-UHFFFAOYSA-N 50072670 CHEMBL3410053 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm501680m 10.7270/Q2K64KRC 25621531 Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072670&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118732107 103966282 CHEMBL3410053 ZINC26995204 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50314030 Cc1[nH]c2ncnc(-c3ccc(NC(=O)N(CCN)c4ccc(Cl)cc4)c(F)c3)c2c1C InChI=1S/C23H22ClFN6O/c1-13-14(2)29-22-20(13)21(27-12-28-22)15-3-8-19(18(25)11-15)30-23(32)31(10-9-26)17-6-4-16(24)5-7-17/h3-8,11-12H,9-10,26H2,1-2H3,(H,30,32)(H,27,28,29) MYINUWNSRFCORJ-UHFFFAOYSA-N 50072727 CHEMBL3410054 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm501680m 10.7270/Q2K64KRC 25621531 Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072727&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118732108 313072661 CHEMBL3410054 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50314031 COCCN(C(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(C)c(C)c12)c1ccc(Cl)cc1 InChI=1S/C24H23ClFN5O2/c1-14-15(2)29-23-21(14)22(27-13-28-23)16-4-9-20(19(26)12-16)30-24(32)31(10-11-33-3)18-7-5-17(25)6-8-18/h4-9,12-13H,10-11H2,1-3H3,(H,30,32)(H,27,28,29) OBXKCXDQQXDOSZ-UHFFFAOYSA-N 50072672 CHEMBL3410056 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm501680m 10.7270/Q2K64KRC 25621531 Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50072672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50072672&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118732109 103966284 CHEMBL3410056 ZINC26990858 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319404 Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1ccccc1 InChI=1S/C19H14ClN3/c20-16-8-4-5-9-17(16)21-14-10-11-15-18(12-14)22-23-19(15)13-6-2-1-3-7-13/h1-12,21H,(H,22,23) DFRPRNRPOSSJQZ-UHFFFAOYSA-N 50172918 (2-Chloro-phenyl)-(3-phenyl-1H-indazol-6-yl)-amine::CHEMBL440566 Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172918&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9928616 104058954 CHEMBL440566 ZINC03816998 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319406 Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NC1CCNCC1 InChI=1S/C25H24ClN5O/c26-21-6-1-2-7-22(21)28-19-8-9-20-23(15-19)30-31-24(20)16-4-3-5-17(14-16)25(32)29-18-10-12-27-13-11-18/h1-9,14-15,18,27-28H,10-13H2,(H,29,32)(H,30,31) VKTAENBLRPMXKK-UHFFFAOYSA-N 50172920 3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(piperidin-4-yl)benzamide::3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-N-piperidin-4-yl-benzamide::CHEMBL194806 Mitogen-activated protein kinase 10 Homo sapiens 1.4 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172920&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44404813 104058956 CHEMBL194806 ZINC28525785 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319407 Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NCCCN1CCOCC1 InChI=1S/C27H28ClN5O2/c28-23-7-1-2-8-24(23)30-21-9-10-22-25(18-21)31-32-26(22)19-5-3-6-20(17-19)27(34)29-11-4-12-33-13-15-35-16-14-33/h1-3,5-10,17-18,30H,4,11-16H2,(H,29,34)(H,31,32) WMTFXHFSJAESMU-UHFFFAOYSA-N 50172921 3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-N-(3-morpholin-4-yl-propyl)-benzamide::CHEMBL198687 Mitogen-activated protein kinase 10 Homo sapiens 3.4 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172921&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10152189 104058957 CHEMBL198687 ZINC28529005 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319408 OC(=O)c1ccc(cc1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12 InChI=1S/C20H14ClN3O2/c21-16-3-1-2-4-17(16)22-14-9-10-15-18(11-14)23-24-19(15)12-5-7-13(8-6-12)20(25)26/h1-11,22H,(H,23,24)(H,25,26) HVLBTSWQHJSANX-UHFFFAOYSA-N 50172922 4-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-benzoic acid::CHEMBL197698 Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172922&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10172440 104058958 CHEMBL197698 ZINC28528371 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319411 N(c1ccccc1)c1ccc2c(n[nH]c2c1)-c1ccccc1 InChI=1S/C19H15N3/c1-3-7-14(8-4-1)19-17-12-11-16(13-18(17)21-22-19)20-15-9-5-2-6-10-15/h1-13,20H,(H,21,22) UCZOJYXXXUINID-UHFFFAOYSA-N 50172925 CHEMBL383177::N,3-diphenyl-1H-indazol-6-amine::Phenyl-(3-phenyl-1H-indazol-6-yl)-amine Mitogen-activated protein kinase 10 Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172925&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10236389 104058960 CHEMBL383177 ZINC03816999 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319415 CN(C)CCNC(=O)c1ccc(cc1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12 InChI=1S/C24H24ClN5O/c1-30(2)14-13-26-24(31)17-9-7-16(8-10-17)23-19-12-11-18(15-22(19)28-29-23)27-21-6-4-3-5-20(21)25/h3-12,15,27H,13-14H2,1-2H3,(H,26,31)(H,28,29) WPHLFVIDUSHWHQ-UHFFFAOYSA-N 50211306 4-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(2-(dimethylamino)ethyl)benzamide::4-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-N-(2-dimethylamino-ethyl)-benzamide::CHEMBL399167 Mitogen-activated protein kinase 10 Homo sapiens 1.9 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211306&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10310219 104087504 CHEMBL399167 ZINC28529003 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319422 COc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1ccccc1 InChI=1S/C20H17N3O/c1-24-19-10-6-5-9-17(19)21-15-11-12-16-18(13-15)22-23-20(16)14-7-3-2-4-8-14/h2-13,21H,1H3,(H,22,23) ZOKHEOBWAYOYGR-UHFFFAOYSA-N 50211303 (2-Methoxy-phenyl)-(3-phenyl-1H-indazol-6-yl)-amine::CHEMBL254443::N-(2-methoxyphenyl)-3-phenyl-1H-indazol-6-amine Mitogen-activated protein kinase 10 Homo sapiens 202 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211303&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10149689 104087501 CHEMBL254443 ZINC28528680 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319424 CN(C)CCNC(=O)c1cccc(c1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12 InChI=1S/C24H24ClN5O/c1-30(2)13-12-26-24(31)17-7-5-6-16(14-17)23-19-11-10-18(15-22(19)28-29-23)27-21-9-4-3-8-20(21)25/h3-11,14-15,27H,12-13H2,1-2H3,(H,26,31)(H,28,29) SCDOWHQVNDXVPB-UHFFFAOYSA-N 50172923 3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-N-(2-dimethylamino-ethyl)-benzamide::CHEMBL198821 Mitogen-activated protein kinase 10 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172923&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10151272 104058959 CHEMBL198821 ZINC28528735 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319425 NC(=O)c1cccc(c1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12 InChI=1S/C20H15ClN4O/c21-16-6-1-2-7-17(16)23-14-8-9-15-18(11-14)24-25-19(15)12-4-3-5-13(10-12)20(22)26/h1-11,23H,(H2,22,26)(H,24,25) OWHSAASMRWOHHO-UHFFFAOYSA-N 50172919 3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-benzamide::CHEMBL199136 Mitogen-activated protein kinase 10 Homo sapiens 3.3 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172919&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44404797 104058955 CHEMBL199136 ZINC28528372 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50319431 OC(=O)c1cccc(c1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12 InChI=1S/C20H14ClN3O2/c21-16-6-1-2-7-17(16)22-14-8-9-15-18(11-14)23-24-19(15)12-4-3-5-13(10-12)20(25)26/h1-11,22H,(H,23,24)(H,25,26) LGTYWJCIEQTIIP-UHFFFAOYSA-N 50172927 3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-benzoic acid::CHEMBL197613 Mitogen-activated protein kinase 10 Homo sapiens 5.3 ChEMBL 10.1016/j.bmcl.2005.06.083 10.7270/Q2JW8DFC 16140012 Swahn, BM; Huerta, F; Kallin, E; Malmstrom, J; Weigelt, T; Viklund, J; Womack, P; Xue, Y; Ohberg, L AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172927&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10215642 104058961 CHEMBL197613 ZINC28528159 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342055 CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1ncc2ccc(=O)n(C3CCOCC3)c2n1 InChI=1S/C22H32N6O3/c1-14(2)24-22(30)26-17-6-4-16(5-7-17)25-21-23-13-15-3-8-19(29)28(20(15)27-21)18-9-11-31-12-10-18/h3,8,13-14,16-18H,4-7,9-12H2,1-2H3,(H,23,25,27)(H2,24,26,30)/t16-,17- PBXFZPKEBIEGOE-QAQDUYKDSA-N 50089224 CHEMBL3577878 Mitogen-activated protein kinase 10 Homo sapiens 204 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089224&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 122178092 103988058 CHEMBL3577878 ZINC26471259 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342056 CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1ncc2ccc(=O)n(C3CCCC3)c2n1 InChI=1S/C22H32N6O2/c1-14(2)24-22(30)26-17-10-8-16(9-11-17)25-21-23-13-15-7-12-19(29)28(20(15)27-21)18-5-3-4-6-18/h7,12-14,16-18H,3-6,8-11H2,1-2H3,(H,23,25,27)(H2,24,26,30)/t16-,17- QJPUIIKZKMYPSK-QAQDUYKDSA-N 50089225 CHEMBL3577877 Mitogen-activated protein kinase 10 Homo sapiens 11 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089225&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 4F2 4Y46 91754589 103988059 CHEMBL3577877 ZINC26386410 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342059 CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1ncc2ccc(=O)n(C)c2n1 InChI=1S/C18H26N6O2/c1-11(2)20-18(26)22-14-7-5-13(6-8-14)21-17-19-10-12-4-9-15(25)24(3)16(12)23-17/h4,9-11,13-14H,5-8H2,1-3H3,(H,19,21,23)(H2,20,22,26)/t13-,14- IEZJTLFFNLOEKV-HDJSIYSDSA-N 50089226 CHEMBL3577876 Mitogen-activated protein kinase 10 Homo sapiens 238 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089226&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146764 103988060 CHEMBL3577876 ZINC26397592 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342060 CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1ncc2ccc(=O)[nH]c2n1 InChI=1S/C17H24N6O2/c1-10(2)19-17(25)21-13-6-4-12(5-7-13)20-16-18-9-11-3-8-14(24)22-15(11)23-16/h3,8-10,12-13H,4-7H2,1-2H3,(H2,19,21,25)(H2,18,20,22,23,24)/t12-,13- ZERPCBZTDATMJJ-JOCQHMNTSA-N 50089227 CHEMBL3577875 Mitogen-activated protein kinase 10 Homo sapiens 2166 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089227&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146817 103988061 CHEMBL3577875 ZINC26387994 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342061 CC(C)NC(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n(C(C)C)c2n1 InChI=1S/C19H28N6O2/c1-12(2)21-19(27)24-9-7-15(8-10-24)22-18-20-11-14-5-6-16(26)25(13(3)4)17(14)23-18/h5-6,11-13,15H,7-10H2,1-4H3,(H,21,27)(H,20,22,23) UVJIRZNCCXDTBQ-UHFFFAOYSA-N 50089237 CHEMBL3577874 Mitogen-activated protein kinase 10 Homo sapiens 28 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089237&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146872 103988071 CHEMBL3577874 ZINC26399405 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342062 CCNC(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n(C(C)C)c2n1 InChI=1S/C18H26N6O2/c1-4-19-18(26)23-9-7-14(8-10-23)21-17-20-11-13-5-6-15(25)24(12(2)3)16(13)22-17/h5-6,11-12,14H,4,7-10H2,1-3H3,(H,19,26)(H,20,21,22) YTNDEFNPJUZDTP-UHFFFAOYSA-N 50089228 CHEMBL3577873 Mitogen-activated protein kinase 10 Homo sapiens 54 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089228&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146871 103988062 CHEMBL3577873 ZINC26386714 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342064 CC(C)C(=O)N1CCC(CC1)Nc1ncc2ccc(=O)n(C(C)C)c2n1 InChI=1S/C19H27N5O2/c1-12(2)18(26)23-9-7-15(8-10-23)21-19-20-11-14-5-6-16(25)24(13(3)4)17(14)22-19/h5-6,11-13,15H,7-10H2,1-4H3,(H,20,21,22) ZEAYLBFKDUMFPX-UHFFFAOYSA-N 50089229 CHEMBL3577872 Mitogen-activated protein kinase 10 Homo sapiens 162 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089229&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146819 103988063 CHEMBL3577872 ZINC26387149 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342066 CCNC(=O)N[C@H]1CC[C@H](CC1)Nc1ncc2ccc(=O)n(C(C)C)c2n1 InChI=1S/C19H28N6O2/c1-4-20-19(27)23-15-8-6-14(7-9-15)22-18-21-11-13-5-10-16(26)25(12(2)3)17(13)24-18/h5,10-12,14-15H,4,6-9H2,1-3H3,(H2,20,23,27)(H,21,22,24)/t14-,15+ VGQNDBIBHCCFKP-GASCZTMLSA-N 50089230 CHEMBL3577871 Mitogen-activated protein kinase 10 Homo sapiens 37 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089230&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146747 103988064 CHEMBL3577871 ZINC26400837 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342067 CC(C)C(=O)N[C@H]1CC[C@H](CC1)Nc1ncc2ccc(=O)n(C(C)C)c2n1 InChI=1S/C20H29N5O2/c1-12(2)19(27)22-15-6-8-16(9-7-15)23-20-21-11-14-5-10-17(26)25(13(3)4)18(14)24-20/h5,10-13,15-16H,6-9H2,1-4H3,(H,22,27)(H,21,23,24)/t15-,16+ SIBBXUMRESEGRS-IYBDPMFKSA-N 50089231 CHEMBL3577870 Mitogen-activated protein kinase 10 Homo sapiens 321 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089231&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146870 103988065 CHEMBL3577870 ZINC26404124 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342068 CC(C)n1c2nc(N[C@H]3CC[C@@H](CC3)NC(=O)NC3CCCC3)ncc2ccc1=O InChI=1S/C22H32N6O2/c1-14(2)28-19(29)12-7-15-13-23-21(27-20(15)28)24-17-8-10-18(11-9-17)26-22(30)25-16-5-3-4-6-16/h7,12-14,16-18H,3-6,8-11H2,1-2H3,(H,23,24,27)(H2,25,26,30)/t17-,18- FPOJVFPVFJTSDR-IYARVYRRSA-N 50089232 CHEMBL3577869 Mitogen-activated protein kinase 10 Homo sapiens 81 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089232&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 122178091 103988066 CHEMBL3577869 ZINC26393574 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342069 CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1ncc2ccc(=O)n(C(C)C)c2n1 InChI=1S/C20H30N6O2/c1-12(2)22-20(28)24-16-8-6-15(7-9-16)23-19-21-11-14-5-10-17(27)26(13(3)4)18(14)25-19/h5,10-13,15-16H,6-9H2,1-4H3,(H,21,23,25)(H2,22,24,28)/t15-,16- FJVVBMGXZMJPOI-WKILWMFISA-N 50089233 CHEMBL3577868 Mitogen-activated protein kinase 10 Homo sapiens 15 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089233&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 519 4Y5H 91754590 103988067 CHEMBL3577868 ZINC26397906 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342073 CCNC(=O)N[C@H]1CC[C@@H](CC1)Nc1ncc2ccc(=O)n(C(C)C)c2n1 InChI=1S/C19H28N6O2/c1-4-20-19(27)23-15-8-6-14(7-9-15)22-18-21-11-13-5-10-16(26)25(12(2)3)17(13)24-18/h5,10-12,14-15H,4,6-9H2,1-3H3,(H2,20,23,27)(H,21,22,24)/t14-,15- VGQNDBIBHCCFKP-SHTZXODSSA-N 50089234 CHEMBL3577867 Mitogen-activated protein kinase 10 Homo sapiens 57 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089234&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146747 103988068 CHEMBL3577867 ZINC26398277 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342074 CC(C)C(=O)N[C@H]1CC[C@@H](CC1)Nc1ncc2ccc(=O)n(C(C)C)c2n1 InChI=1S/C20H29N5O2/c1-12(2)19(27)22-15-6-8-16(9-7-15)23-20-21-11-14-5-10-17(26)25(13(3)4)18(14)24-20/h5,10-13,15-16H,6-9H2,1-4H3,(H,22,27)(H,21,23,24)/t15-,16- SIBBXUMRESEGRS-WKILWMFISA-N 50089235 CHEMBL3577866 Mitogen-activated protein kinase 10 Homo sapiens 31 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089235&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146870 103988069 CHEMBL3577866 ZINC26399879 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342075 CC(C)n1c2nc(N[C@H]3CC[C@H](N)CC3)ncc2ccc1=O InChI=1S/C16H23N5O/c1-10(2)21-14(22)8-3-11-9-18-16(20-15(11)21)19-13-6-4-12(17)5-7-13/h3,8-10,12-13H,4-7,17H2,1-2H3,(H,18,19,20)/t12-,13- VHNVLLBWEGOZMB-JOCQHMNTSA-N 50089238 CHEMBL3577865 Mitogen-activated protein kinase 10 Homo sapiens 201 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089238&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146891 103988072 CHEMBL3577865 ZINC26396838 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342076 CC(C)n1c2nc(NC3CCOCC3)ncc2ccc1=O InChI=1S/C15H20N4O2/c1-10(2)19-13(20)4-3-11-9-16-15(18-14(11)19)17-12-5-7-21-8-6-12/h3-4,9-10,12H,5-8H2,1-2H3,(H,16,17,18) OYXVJMGNNKEOSX-UHFFFAOYSA-N 50089236 CHEMBL3577862 Mitogen-activated protein kinase 10 Homo sapiens 532 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089236&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 122178088 103988070 CHEMBL3577862 ZINC26472182 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342077 CC(C)C[C@@H](Nc1ncc2ccc(=O)n(C(C)C)c2n1)C(O)=O InChI=1S/C16H22N4O3/c1-9(2)7-12(15(22)23)18-16-17-8-11-5-6-13(21)20(10(3)4)14(11)19-16/h5-6,8-10,12H,7H2,1-4H3,(H,22,23)(H,17,18,19)/t12-/m1/s1 YHJBRZOVWBZYGH-GFCCVEGCSA-N 50089239 CHEMBL3577861 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089239&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 122178087 103988073 CHEMBL3577861 ZINC26400853 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342078 CC[C@H](C)[C@@H](CO)Nc1ncc2ccc(=O)n(C(C)C)c2n1 InChI=1S/C16H24N4O2/c1-5-11(4)13(9-21)18-16-17-8-12-6-7-14(22)20(10(2)3)15(12)19-16/h6-8,10-11,13,21H,5,9H2,1-4H3,(H,17,18,19)/t11-,13+/m0/s1 LCZYYBHEILBUKK-WCQYABFASA-N 50089240 CHEMBL3577860 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089240&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 122178086 103988074 CHEMBL3577860 ZINC26396724 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342082 CC(C)n1c2nc(ncc2ccc1=O)N1CCC(CO)CC1 InChI=1S/C16H22N4O2/c1-11(2)20-14(22)4-3-13-9-17-16(18-15(13)20)19-7-5-12(10-21)6-8-19/h3-4,9,11-12,21H,5-8,10H2,1-2H3 PZCOVRMQVKTFHC-UHFFFAOYSA-N 50089241 CHEMBL3577859 Mitogen-activated protein kinase 10 Homo sapiens 3300 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089241&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146868 103988075 CHEMBL3577859 ZINC26391966 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342083 CC(C)c1nc2nc(N[C@H]3CC[C@H](O)CC3)ncc2c(=O)[nH]1 InChI=1S/C15H21N5O2/c1-8(2)12-18-13-11(14(22)19-12)7-16-15(20-13)17-9-3-5-10(21)6-4-9/h7-10,21H,3-6H2,1-2H3,(H2,16,17,18,19,20,22)/t9-,10- BHYDYRDKFFSVLI-MGCOHNPYSA-N 50089242 CHEMBL3577858 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089242&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118144221 103988076 CHEMBL3577858 ZINC26404116 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342084 O[C@H]1CC[C@@H](CC1)Nc1ncc2ccc(nc2n1)N1CCCC1 InChI=1S/C17H23N5O/c23-14-6-4-13(5-7-14)19-17-18-11-12-3-8-15(20-16(12)21-17)22-9-1-2-10-22/h3,8,11,13-14,23H,1-2,4-7,9-10H2,(H,18,19,20,21)/t13-,14- LXNOQKIBARYULG-HDJSIYSDSA-N 50089243 CHEMBL3577857 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089243&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146749 103988077 CHEMBL3577857 ZINC26402980 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342085 O[C@H]1CC[C@@H](CC1)Nc1ncc2ccc(nc2n1)C1CC1 InChI=1S/C16H20N4O/c21-13-6-4-12(5-7-13)18-16-17-9-11-3-8-14(10-1-2-10)19-15(11)20-16/h3,8-10,12-13,21H,1-2,4-7H2,(H,17,18,19,20)/t12-,13- HDODMRCSZYUGPO-JOCQHMNTSA-N 50089222 CHEMBL3577856 Mitogen-activated protein kinase 10 Homo sapiens 860 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089222&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146772 103988056 CHEMBL3577856 ZINC26391067 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50342086 CC(C)n1c2nc(N[C@H]3CC[C@H](O)CC3)ncc2ccc1=O InChI=1S/C16H22N4O2/c1-10(2)20-14(22)8-3-11-9-17-16(19-15(11)20)18-12-4-6-13(21)7-5-12/h3,8-10,12-13,21H,4-7H2,1-2H3,(H,17,18,19)/t12-,13- PTVSTQCTVOIQBP-JOCQHMNTSA-N 50089223 CHEMBL3577855 Mitogen-activated protein kinase 10 Homo sapiens 58 ChEMBL 10.1021/ml500474d 10.7270/Q2KH0Q2N 25893042 Zheng, K; Park, CM; Iqbal, S; Hernandez, P; Park, H; LoGrasso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089223&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118146892 103988057 CHEMBL3577855 ZINC26180481 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50336847 CCn1nc(C#Cc2cc(ccc2C)C(=O)Nc2ccc(CN3CCN(C)CC3)c(c2)C(F)(F)F)c2c(N)ncnc12 InChI=1S/C30H31F3N8O/c1-4-41-28-26(27(34)35-18-36-28)25(38-41)10-8-20-15-21(6-5-19(20)2)29(42)37-23-9-7-22(24(16-23)30(31,32)33)17-40-13-11-39(3)12-14-40/h5-7,9,15-16,18H,4,11-14,17H2,1-3H3,(H,37,42)(H2,34,35,36) BNRXMSGHPVYSDK-UHFFFAOYSA-N 50086441 CHEMBL3426225::US10266537, Compound 3 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b00270 10.7270/Q2J38V91 25835317 Zhang, CH; Zheng, MW; Li, YP; Lin, XD; Huang, M; Zhong, L; Li, GB; Zhang, RJ; Lin, WT; Jiao, Y; Wu, XA; Yang, J; Xiang, R; Chen, LJ; Zhao, YL; Cheng, W; Wei, YQ; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50086441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50086441&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118737057 103985649 CHEMBL3426225 ZINC27650632 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50329723 OC1C[C@@H]2CC[C@@H](C1)N2c1ccc(cc1)-c1n[nH]c2ccc(cc12)C(=O)N[C@H](C1CC1)c1ccccn1 50081537 CHEMBL3422092 Mitogen-activated protein kinase 10 Homo sapiens 68 ChEMBL 10.1021/jm501740a 10.7270/Q2Q52RCN 25763473 Liu, Y; Lang, Y; Patel, NK; Ng, G; Laufer, R; Li, SW; Edwards, L; Forrest, B; Sampson, PB; Feher, M; Ban, F; Awrey, DE; Beletskaya, I; Mao, G; Hodgson, R; Plotnikova, O; Qiu, W; Chirgadze, NY; Mason, JM; Wei, X; Lin, DC; Che, Y; Kiarash, R; Madeira, B; Fletcher, GC; Mak, TW; Bray, MR; Pauls, HW EntreMed Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081537&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118988042 313074333 CHEMBL3422092 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331027 CC(=O)N1CCC(CC1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1 InChI=1S/C24H25N5O2/c1-17(30)29-13-9-18(10-14-29)24(31)28-23-16-20(8-12-26-23)19-7-11-25-22(15-19)27-21-5-3-2-4-6-21/h2-8,11-12,15-16,18H,9-10,13-14H2,1H3,(H,25,27)(H,26,28,31) CCZSCWIBOWLLIO-UHFFFAOYSA-N 50178825 1-acetyl-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)piperidine-4-carboxamide::CHEMBL204757 Mitogen-activated protein kinase 10 Homo sapiens 44 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178825&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408669 104064098 CHEMBL204757 ZINC28570289 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331028 COc1ccccc1Nc1cc(ccn1)-c1ccnc(Nc2ccccc2OC)c1 InChI=1S/C24H22N4O2/c1-29-21-9-5-3-7-19(21)27-23-15-17(11-13-25-23)18-12-14-26-24(16-18)28-20-8-4-6-10-22(20)30-2/h3-16H,1-2H3,(H,25,27)(H,26,28) BEJCWWBEHHBUTJ-UHFFFAOYSA-N 50178826 CHEMBL437706::N-(2-methoxyphenyl)-4-(2-(2-methoxyphenylamino)pyridin-4-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 528 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178826&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10475988 104064099 CHEMBL437706 ZINC28570283 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331030 Fc1ccc(Nc2cc(ccn2)-c2ccnc(NC(=O)C3CCOC3)c2)cc1 InChI=1S/C21H19FN4O2/c22-17-1-3-18(4-2-17)25-19-11-14(5-8-23-19)15-6-9-24-20(12-15)26-21(27)16-7-10-28-13-16/h1-6,8-9,11-12,16H,7,10,13H2,(H,23,25)(H,24,26,27) DGTWHZKHMUDXOY-UHFFFAOYSA-N 50178827 (+)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide::(-)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide::CHEMBL203839 Mitogen-activated protein kinase 10 Homo sapiens 3.00 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178827&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408944 104064100 CHEMBL203839 ZINC28571307 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331035 Cc1ccccc1Nc1cc(ccn1)-c1ccnc(Nc2ccccc2C)c1 InChI=1S/C24H22N4/c1-17-7-3-5-9-21(17)27-23-15-19(11-13-25-23)20-12-14-26-24(16-20)28-22-10-6-4-8-18(22)2/h3-16H,1-2H3,(H,25,27)(H,26,28) SZLFVJUTJRXHTD-UHFFFAOYSA-N 50178831 4-(2-(o-toluidino)pyridin-4-yl)-N-o-tolylpyridin-2-amine::CHEMBL205561 Mitogen-activated protein kinase 10 Homo sapiens 652 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178831&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10384284 104064104 CHEMBL205561 ZINC28571309 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331036 O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)C1CCOC1 InChI=1S/C21H20N4O2/c26-21(17-8-11-27-14-17)25-20-13-16(7-10-23-20)15-6-9-22-19(12-15)24-18-4-2-1-3-5-18/h1-7,9-10,12-13,17H,8,11,14H2,(H,22,24)(H,23,25,26) YZIQMIAREGGHFQ-UHFFFAOYSA-N 50178832 CHEMBL203535::N-(2'-(phenylamino)-4,4'-bipyridin-2-yl)tetrahydrofuran-3-carboxamide::N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178832&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10247954 104064105 CHEMBL203535 ZINC28571781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331037 Nc1ccccc1Nc1cc(ccn1)-c1ccnc(Nc2ccccc2N)c1 InChI=1S/C22H20N6/c23-17-5-1-3-7-19(17)27-21-13-15(9-11-25-21)16-10-12-26-22(14-16)28-20-8-4-2-6-18(20)24/h1-14H,23-24H2,(H,25,27)(H,26,28) HCYVXZBPVNQTND-UHFFFAOYSA-N 50178834 CHEMBL203792::N1-(4-(2-(2-aminophenylamino)pyridin-4-yl)pyridin-2-yl)benzene-1,2-diamine Mitogen-activated protein kinase 10 Homo sapiens 108 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178834&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10384407 104064107 CHEMBL203792 ZINC52627493 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331038 FC(F)(F)c1cccc(Nc2cc(ccn2)-c2ccnc(Nc3cccc(c3)C(F)(F)F)c2)c1 InChI=1S/C24H16F6N4/c25-23(26,27)17-3-1-5-19(13-17)33-21-11-15(7-9-31-21)16-8-10-32-22(12-16)34-20-6-2-4-18(14-20)24(28,29)30/h1-14H,(H,31,33)(H,32,34) MQFVUUFUGNJMNK-UHFFFAOYSA-N 50178833 CHEMBL383770::N-(3-(trifluoromethyl)phenyl)-4-(2-(3-(trifluoromethyl)phenylamino)pyridin-4-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178833&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9982333 104064106 CHEMBL383770 ZINC28571604 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331039 O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)C1CCOCC1 InChI=1S/C22H22N4O2/c27-22(16-8-12-28-13-9-16)26-21-15-18(7-11-24-21)17-6-10-23-20(14-17)25-19-4-2-1-3-5-19/h1-7,10-11,14-16H,8-9,12-13H2,(H,23,25)(H,24,26,27) CBHOUOHFUVTLFG-UHFFFAOYSA-N 50178836 CHEMBL203059::N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydro-2H-pyran-4-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178836&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408641 104064109 CHEMBL203059 ZINC28572100 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331041 CCOc1ccccc1Nc1cc(ccn1)-c1ccnc(Nc2ccccc2OCC)c1 InChI=1S/C26H26N4O2/c1-3-31-23-11-7-5-9-21(23)29-25-17-19(13-15-27-25)20-14-16-28-26(18-20)30-22-10-6-8-12-24(22)32-4-2/h5-18H,3-4H2,1-2H3,(H,27,29)(H,28,30) FCOGOYOJNYQGJG-UHFFFAOYSA-N 50178835 CHEMBL202961::N-(2-ethoxyphenyl)-4-(2-(2-ethoxyphenylamino)pyridin-4-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 693 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178835&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10477561 104064108 CHEMBL202961 ZINC28572044 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331044 Fc1ccccc1Nc1cc(ccn1)-c1ccnc(Nc2ccccc2F)c1 InChI=1S/C22H16F2N4/c23-17-5-1-3-7-19(17)27-21-13-15(9-11-25-21)16-10-12-26-22(14-16)28-20-8-4-2-6-18(20)24/h1-14H,(H,25,27)(H,26,28) SKJICGSOFSPBPD-UHFFFAOYSA-N 50178840 CHEMBL203289::N-(2-fluorophenyl)-4-(2-(2-fluorophenylamino)pyridin-4-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178840&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11740117 104064113 CHEMBL203289 ZINC28571375 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331045 CC(=O)N1CCCC(C1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccc(F)cc2)c1 InChI=1S/C24H24FN5O2/c1-16(31)30-12-2-3-19(15-30)24(32)29-23-14-18(9-11-27-23)17-8-10-26-22(13-17)28-21-6-4-20(25)5-7-21/h4-11,13-14,19H,2-3,12,15H2,1H3,(H,26,28)(H,27,29,32) GLWXMYOBTQMICW-UHFFFAOYSA-N 50178838 1-acetyl-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)piperidine-3-carboxamide::CHEMBL206466 Mitogen-activated protein kinase 10 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178838&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408936 104064111 CHEMBL206466 ZINC28571437 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331047 COC1CCC(CC1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1 InChI=1S/C24H26N4O2/c1-30-21-9-7-17(8-10-21)24(29)28-23-16-19(12-14-26-23)18-11-13-25-22(15-18)27-20-5-3-2-4-6-20/h2-6,11-17,21H,7-10H2,1H3,(H,25,27)(H,26,28,29) PVBFXVLGPVXIGL-UHFFFAOYSA-N 50178841 4-methoxy-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)cyclohexanecarboxamide::CHEMBL203009 Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178841&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10092520 104064114 CHEMBL203009 ZINC28571101 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331050 CC(=O)N1CCC[C@@H](C1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccc(F)cc2)c1 InChI=1S/C24H24FN5O2/c1-16(31)30-12-2-3-19(15-30)24(32)29-23-14-18(9-11-27-23)17-8-10-26-22(13-17)28-21-6-4-20(25)5-7-21/h4-11,13-14,19H,2-3,12,15H2,1H3,(H,26,28)(H,27,29,32)/t19-/m0/s1 GLWXMYOBTQMICW-IBGZPJMESA-N 50178842 (3S)-1-acetyl-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)piperidine-3-carboxamide::CHEMBL202666 Mitogen-activated protein kinase 10 Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178842&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408909 104064115 CHEMBL202666 ZINC28571437 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331056 CC(=O)N1CCCC(C1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1 InChI=1S/C24H25N5O2/c1-17(30)29-13-5-6-20(16-29)24(31)28-23-15-19(10-12-26-23)18-9-11-25-22(14-18)27-21-7-3-2-4-8-21/h2-4,7-12,14-15,20H,5-6,13,16H2,1H3,(H,25,27)(H,26,28,31) QSYYXXNSCFXCDV-UHFFFAOYSA-N 50178846 1-acetyl-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)piperidine-3-carboxamide::CHEMBL203225 Mitogen-activated protein kinase 10 Homo sapiens 9 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178846&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408825 104064119 CHEMBL203225 ZINC28572124 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331060 FC(F)(F)c1ccc(Nc2cc(ccn2)-c2ccnc(Nc3ccc(cc3)C(F)(F)F)c2)cc1 InChI=1S/C24H16F6N4/c25-23(26,27)17-1-5-19(6-2-17)33-21-13-15(9-11-31-21)16-10-12-32-22(14-16)34-20-7-3-18(4-8-20)24(28,29)30/h1-14H,(H,31,33)(H,32,34) BSKGCEKODYHOJI-UHFFFAOYSA-N 50178845 CHEMBL378591::N-(4-(trifluoromethyl)phenyl)-4-(2-(4-(trifluoromethyl)phenylamino)pyridin-4-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178845&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9826147 104064118 CHEMBL378591 ZINC28571010 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331061 O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)c1ccco1 InChI=1S/C21H16N4O2/c26-21(18-7-4-12-27-18)25-20-14-16(9-11-23-20)15-8-10-22-19(13-15)24-17-5-2-1-3-6-17/h1-14H,(H,22,24)(H,23,25,26) RMQLRJIXYUSAHW-UHFFFAOYSA-N 50178837 CHEMBL380724::N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)furan-2-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178837&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10066845 104064110 CHEMBL380724 ZINC28572127 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331063 O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)c1cccnc1 InChI=1S/C22H17N5O/c28-22(18-5-4-10-23-15-18)27-21-14-17(9-12-25-21)16-8-11-24-20(13-16)26-19-6-2-1-3-7-19/h1-15H,(H,24,26)(H,25,27,28) QAJYGCFIHFNUML-UHFFFAOYSA-N 50178828 CHEMBL380625::N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)nicotinamide Mitogen-activated protein kinase 10 Homo sapiens 175 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178828&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10021870 104064101 CHEMBL380625 ZINC28571093 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331067 Fc1ccc(Nc2cc(ccn2)-c2ccnc(Nc3ccc(F)cc3)c2)cc1 InChI=1S/C22H16F2N4/c23-17-1-5-19(6-2-17)27-21-13-15(9-11-25-21)16-10-12-26-22(14-16)28-20-7-3-18(24)4-8-20/h1-14H,(H,25,27)(H,26,28) PVQXGVSFLRLNTD-UHFFFAOYSA-N 50178848 CHEMBL205672::N-(4-fluorophenyl)-4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178848&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10452031 104064121 CHEMBL205672 ZINC28571291 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331068 Cc1cnc(cn1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1 InChI=1S/C22H18N6O/c1-15-13-26-19(14-25-15)22(29)28-21-12-17(8-10-24-21)16-7-9-23-20(11-16)27-18-5-3-2-4-6-18/h2-14H,1H3,(H,23,27)(H,24,28,29) QCQCMNUQTMIKHU-UHFFFAOYSA-N 50178844 5-methyl-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)pyrazine-2-carboxamide::CHEMBL205402 Mitogen-activated protein kinase 10 Homo sapiens 33 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178844&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10091293 104064117 CHEMBL205402 ZINC28571285 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331070 Fc1ccc(Nc2cc(ccn2)-c2ccnc(NC(=O)C3CCOC3)c2)cc1 InChI=1S/C21H19FN4O2/c22-17-1-3-18(4-2-17)25-19-11-14(5-8-23-19)15-6-9-24-20(12-15)26-21(27)16-7-10-28-13-16/h1-6,8-9,11-12,16H,7,10,13H2,(H,23,25)(H,24,26,27) DGTWHZKHMUDXOY-UHFFFAOYSA-N 50178827 (+)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide::(-)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide::CHEMBL203839 Mitogen-activated protein kinase 10 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178827&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408944 104064100 CHEMBL203839 ZINC28571307 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331071 COCCC(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1 InChI=1S/C20H20N4O2/c1-26-12-9-20(25)24-19-14-16(8-11-22-19)15-7-10-21-18(13-15)23-17-5-3-2-4-6-17/h2-8,10-11,13-14H,9,12H2,1H3,(H,21,23)(H,22,24,25) IKVLVCWXKRSDND-UHFFFAOYSA-N 50178829 3-methoxy-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)propanamide::CHEMBL379254 Mitogen-activated protein kinase 10 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178829&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10472936 104064102 CHEMBL379254 ZINC28571404 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331072 CO[C@H]1CC[C@@H](CC1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccc(F)cc2)c1 InChI=1S/C24H25FN4O2/c1-31-21-8-2-16(3-9-21)24(30)29-23-15-18(11-13-27-23)17-10-12-26-22(14-17)28-20-6-4-19(25)5-7-20/h4-7,10-16,21H,2-3,8-9H2,1H3,(H,26,28)(H,27,29,30)/t16-,21- ACGBFWCBVIXTPZ-OQIWPSSASA-N 50178847 CHEMBL203631::N-{2'-[(4-FLUOROPHENYL)AMINO]-4,4'-BIPYRIDIN-2-YL}-4-METHOXYCYCLOHEXANECARBOXAMIDE::trans-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-4-methoxycyclohexanecarboxamide Mitogen-activated protein kinase 10 Homo sapiens 235 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178847&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JNK 2EXC 10364826 104064120 CHEMBL203631 DB08025 ZINC16052742 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331073 CO[C@H]1CC[C@H](CC1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccc(F)cc2)c1 InChI=1S/C24H25FN4O2/c1-31-21-8-2-16(3-9-21)24(30)29-23-15-18(11-13-27-23)17-10-12-26-22(14-17)28-20-6-4-19(25)5-7-20/h4-7,10-16,21H,2-3,8-9H2,1H3,(H,26,28)(H,27,29,30)/t16-,21+ ACGBFWCBVIXTPZ-NBEIKUQISA-N 50178839 CHEMBL202676::cis-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-4-methoxycyclohexanecarboxamide Mitogen-activated protein kinase 10 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178839&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JNK 2EXC 10364826 104064112 CHEMBL202676 ZINC16052742 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331074 CC(=O)N1CCCCC1C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1 InChI=1S/C24H25N5O2/c1-17(30)29-14-6-5-9-21(29)24(31)28-23-16-19(11-13-26-23)18-10-12-25-22(15-18)27-20-7-3-2-4-8-20/h2-4,7-8,10-13,15-16,21H,5-6,9,14H2,1H3,(H,25,27)(H,26,28,31) SUWUWYNHAIZHCH-UHFFFAOYSA-N 50178849 1-acetyl-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)piperidine-2-carboxamide::CHEMBL383678 Mitogen-activated protein kinase 10 Homo sapiens 207 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178849&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408826 104064122 CHEMBL383678 ZINC28572126 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331075 CC(=O)N1CCC[C@H](C1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccc(F)cc2)c1 InChI=1S/C24H24FN5O2/c1-16(31)30-12-2-3-19(15-30)24(32)29-23-14-18(9-11-27-23)17-8-10-26-22(13-17)28-21-6-4-20(25)5-7-21/h4-11,13-14,19H,2-3,12,15H2,1H3,(H,26,28)(H,27,29,32)/t19-/m1/s1 GLWXMYOBTQMICW-LJQANCHMSA-N 50178843 (3R)-1-acetyl-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)piperidine-3-carboxamide::CHEMBL202639 Mitogen-activated protein kinase 10 Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178843&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408908 104064116 CHEMBL202639 ZINC28571436 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50331077 Fc1ccc(Nc2cc(ccn2)-c2ccnc(NC(=O)C3CCOCC3)c2)cc1 InChI=1S/C22H21FN4O2/c23-18-1-3-19(4-2-18)26-20-13-16(5-9-24-20)17-6-10-25-21(14-17)27-22(28)15-7-11-29-12-8-15/h1-6,9-10,13-15H,7-8,11-12H2,(H,24,26)(H,25,27,28) RWOFIHYHMILOTJ-UHFFFAOYSA-N 50178830 CHEMBL205078::N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydro-2H-pyran-4-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2005.11.039 10.7270/Q2KP81R3 16337120 Swahn, BM; Xue, Y; Arzel, E; Kallin, E; Magnus, A; Plobeck, N; Viklund, J AstraZeneca R&D Södertälje http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178830&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44408670 104064103 CHEMBL205078 ZINC28570345 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50359424 Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C29H28F3N5O2/c1-19-5-6-21(27(38)35-24-4-2-3-23(17-24)29(30,31)32)16-25(19)20-7-8-26-22(15-20)18-34-28(36-26)33-9-10-37-11-13-39-14-12-37/h2-8,15-18H,9-14H2,1H3,(H,35,38)(H,33,34,36) DVRSTRMZTAPMKO-UHFFFAOYSA-N 50194668 4-methyl-3-(2-(2-morpholinoethylamino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamide::CHEMBL215943 Mitogen-activated protein kinase 10 Homo sapiens 145 ChEMBL 10.1021/jm0605482 10.7270/Q29G5MFD 16970394 DiMauro, EF; Newcomb, J; Nunes, JJ; Bemis, JE; Boucher, C; Buchanan, JL; Buckner, WH; Cee, VJ; Chai, L; Deak, HL; Epstein, LF; Faust, T; Gallant, P; Geuns-Meyer, SD; Gore, A; Gu, Y; Henkle, B; Hodous, BL; Hsieh, F; Huang, X; Kim, JL; Lee, JH; Martin, MW; Masse, CE; McGowan, DC; Metz, D; Mohn, D; Morgenstern, KA; Oliveira-dos-Santos, A; Patel, VF; Powers, D; Rose, PE; Schneider, S; Tomlinson, SA; Tudor, YY; Turci, SM; Welcher, AA; White, RD; Zhao, H; Zhu, L; Zhu, X Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194668&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16086114 104076930 CHEMBL215943 ZINC34802946 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50359529 CNc1ncc2cc(ccc2n1)-c1cc(ccc1C)C(=O)Nc1cc(ccc1OC1CCN(C)CC1)C(F)(F)F InChI=1S/C30H30F3N5O2/c1-18-4-5-20(15-24(18)19-6-8-25-21(14-19)17-35-29(34-2)37-25)28(39)36-26-16-22(30(31,32)33)7-9-27(26)40-23-10-12-38(3)13-11-23/h4-9,14-17,23H,10-13H2,1-3H3,(H,36,39)(H,34,35,37) DGUSFVFTIHATAT-UHFFFAOYSA-N 50194671 4-methyl-3-(2-(methylamino)quinazolin-6-yl)-N-(2-(1-methylpiperidin-4-yloxy)-5-(trifluoromethyl)phenyl)benzamide::CHEMBL386661 Mitogen-activated protein kinase 10 Homo sapiens >5000 ChEMBL 10.1021/jm0605482 10.7270/Q29G5MFD 16970394 DiMauro, EF; Newcomb, J; Nunes, JJ; Bemis, JE; Boucher, C; Buchanan, JL; Buckner, WH; Cee, VJ; Chai, L; Deak, HL; Epstein, LF; Faust, T; Gallant, P; Geuns-Meyer, SD; Gore, A; Gu, Y; Henkle, B; Hodous, BL; Hsieh, F; Huang, X; Kim, JL; Lee, JH; Martin, MW; Masse, CE; McGowan, DC; Metz, D; Mohn, D; Morgenstern, KA; Oliveira-dos-Santos, A; Patel, VF; Powers, D; Rose, PE; Schneider, S; Tomlinson, SA; Tudor, YY; Turci, SM; Welcher, AA; White, RD; Zhao, H; Zhu, L; Zhu, X Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50194671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50194671&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16086104 104076933 CHEMBL386661 ZINC34804570 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50357894 NC(=O)c1cnc2[nH]ccc2c1N[C@@H]1CCN(C[C@@H]1F)c1ccc(cn1)C#N InChI=1S/C15H23N5O5/c1-2-4-24-5-3-9-18-13(16)10-14(19-9)20(7-17-10)15-12(23)11(22)8(6-21)25-15/h7-8,11-12,15,21-23H,2-6H2,1H3,(H2,16,18,19)/t8-,11+,12+,15?/m1/s1 QZIQXTJSJONATN-ZCUDWAKFSA-N 50095952 CHEMBL3593777 Mitogen-activated protein kinase 10 Homo sapiens 560 ChEMBL 10.1016/j.bmc.2015.05.034 10.7270/Q2DZ0B21 26071372 Nakajima, Y; Inoue, T; Nakai, K; Mukoyoshi, K; Hamaguchi, H; Hatanaka, K; Sasaki, H; Tanaka, A; Takahashi, F; Kunikawa, S; Usuda, H; Moritomo, A; Higashi, Y; Inami, M; Shirakami, S Astellas Pharma Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50095952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50095952&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59292007 103993558 CHEMBL3593777 ZINC27626685 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50363204 CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1 InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33) UQFRSHRWRKYNDE-UHFFFAOYSA-N 16016 CHEMBL437747::N-cyclohexyl-4-[4-(3,4-dichlorophenyl)-2-(piperidin-4-yl)-1-propyl-1H-imidazol-5-yl]pyrimidin-2-amine::N-cyclohexyl-4-[4-(3,4-dichlorophenyl)-2-piperidin-4-yl-1-propyl-1H-imidazol-5-yl]pyrimidin-2-amine::imidazole-pyrimidine compound 2 Mitogen-activated protein kinase 10 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2006.10.013 10.7270/Q2JQ10NQ 17055723 Liu, G; Zhao, H; Liu, B; Xin, Z; Liu, M; Serby, MD; Lubbers, NL; Widomski, DL; Polakowski, JS; Beno, DW; Trevillyan, JM; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16016&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 880 4Z9L 447873 46516285 CHEMBL437747 DB02388 ZINC12501995 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373885 COC(=O)CSc1nc(c(-c2ccnc(NC(C)=O)c2)n1C)-c1ccc(F)cc1 InChI=1S/C20H19FN4O3S/c1-12(26)23-16-10-14(8-9-22-16)19-18(13-4-6-15(21)7-5-13)24-20(25(19)2)29-11-17(27)28-3/h4-10H,11H2,1-3H3,(H,22,23,26) WBOHIDITFNXQBL-UHFFFAOYSA-N 50103012 CHEMBL3394094 Mitogen-activated protein kinase 10 Homo sapiens 199 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103012&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725886 318491139 CHEMBL3394094 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373886 CN(C)C(=O)CSc1nc(c(-c2ccnc(NC(C)=O)c2)n1C)-c1ccc(F)cc1 InChI=1S/C21H22FN5O2S/c1-13(28)24-17-11-15(9-10-23-17)20-19(14-5-7-16(22)8-6-14)25-21(27(20)4)30-12-18(29)26(2)3/h5-11H,12H2,1-4H3,(H,23,24,28) OUELWBJKGPHPKY-UHFFFAOYSA-N 50103013 CHEMBL3394095 Mitogen-activated protein kinase 10 Homo sapiens 1186 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103013&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725887 318491140 CHEMBL3394095 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373887 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C\C(O)=O)n1CC1CC1)-c1ccc(F)cc1 InChI=1S/C23H21FN4O3S/c1-14(29)26-19-12-17(8-10-25-19)22-21(16-4-6-18(24)7-5-16)27-23(32-11-9-20(30)31)28(22)13-15-2-3-15/h4-12,15H,2-3,13H2,1H3,(H,30,31)(H,25,26,29)/b11-9+ PPJNVHSJLHVKBI-PKNBQFBNSA-N 50102917 CHEMBL3394117 Mitogen-activated protein kinase 10 Homo sapiens 170 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102917&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725908 103999282 CHEMBL3394117 ZINC13478458 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373888 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1C1CC1)-c1ccc(F)cc1 InChI=1S/C22H19FN4O3S/c1-13(28)25-18-12-15(8-10-24-18)21-20(14-2-4-16(23)5-3-14)26-22(27(21)17-6-7-17)31-11-9-19(29)30/h2-5,8-12,17H,6-7H2,1H3,(H,29,30)(H,24,25,28)/b11-9- YMRWBKJYJJXFPZ-LUAWRHEFSA-N 50103000 CHEMBL3394102 Mitogen-activated protein kinase 10 Homo sapiens 82 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103000&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725894 318491127 CHEMBL3394102 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373889 OC(=O)\C=C/Sc1nc(c(-c2ccnc(Nc3ccccc3)c2)n1CC1CC1)-c1ccc(F)cc1 InChI=1S/C27H23FN4O2S/c28-21-10-8-19(9-11-21)25-26(20-12-14-29-23(16-20)30-22-4-2-1-3-5-22)32(17-18-6-7-18)27(31-25)35-15-13-24(33)34/h1-5,8-16,18H,6-7,17H2,(H,29,30)(H,33,34)/b15-13- HGNBJCGHXCRROP-SQFISAMPSA-N 50103103 CHEMBL3394123 Mitogen-activated protein kinase 10 Homo sapiens 54 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103103&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725913 318491141 CHEMBL3394123 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373891 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1C1CCC1)-c1ccc(F)cc1 InChI=1S/C23H21FN4O3S/c1-14(29)26-19-13-16(9-11-25-19)22-21(15-5-7-17(24)8-6-15)27-23(32-12-10-20(30)31)28(22)18-3-2-4-18/h5-13,18H,2-4H2,1H3,(H,30,31)(H,25,26,29)/b12-10- CMNVQEMSBQLCIT-BENRWUELSA-N 50103001 CHEMBL3394103 Mitogen-activated protein kinase 10 Homo sapiens 47 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103001&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725895 318491128 CHEMBL3394103 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373892 OC(=O)\C=C\Sc1nc(c(-c2ccnc(Nc3ccccc3)c2)n1CC1CC1)-c1ccc(F)cc1 InChI=1S/C27H23FN4O2S/c28-21-10-8-19(9-11-21)25-26(20-12-14-29-23(16-20)30-22-4-2-1-3-5-22)32(17-18-6-7-18)27(31-25)35-15-13-24(33)34/h1-5,8-16,18H,6-7,17H2,(H,29,30)(H,33,34)/b15-13+ HGNBJCGHXCRROP-FYWRMAATSA-N 50103105 CHEMBL3394124 Mitogen-activated protein kinase 10 Homo sapiens 213 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103105&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725914 318491143 CHEMBL3394124 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373893 OC(=O)\C=C/Sc1nc(c([nH]1)-c1ccnc(Nc2ccccc2)c1)-c1ccc(F)cc1 InChI=1S/C23H17FN4O2S/c24-17-8-6-15(7-9-17)21-22(28-23(27-21)31-13-11-20(29)30)16-10-12-25-19(14-16)26-18-4-2-1-3-5-18/h1-14H,(H,25,26)(H,27,28)(H,29,30)/b13-11- ARVSBTXGNYKBJK-QBFSEMIESA-N 50103129 CHEMBL3394125 Mitogen-activated protein kinase 10 Homo sapiens 17 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103129&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725915 103999473 CHEMBL3394125 ZINC13912046 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373897 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1C1CCCCC1)-c1ccc(F)cc1 InChI=1S/C25H25FN4O3S/c1-16(31)28-21-15-18(11-13-27-21)24-23(17-7-9-19(26)10-8-17)29-25(34-14-12-22(32)33)30(24)20-5-3-2-4-6-20/h7-15,20H,2-6H2,1H3,(H,32,33)(H,27,28,31)/b14-12- GTIQIAGCTCXGCN-OWBHPGMISA-N 50103008 CHEMBL3394105 Mitogen-activated protein kinase 10 Homo sapiens 133 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103008&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725897 318491135 CHEMBL3394105 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373898 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1CC1CC1)-c1ccc(F)cc1 InChI=1S/C23H21FN4O3S/c1-14(29)26-19-12-17(8-10-25-19)22-21(16-4-6-18(24)7-5-16)27-23(32-11-9-20(30)31)28(22)13-15-2-3-15/h4-12,15H,2-3,13H2,1H3,(H,30,31)(H,25,26,29)/b11-9- PPJNVHSJLHVKBI-LUAWRHEFSA-N 50103104 CHEMBL3394106 Mitogen-activated protein kinase 10 Homo sapiens 18 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103104&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 101913690 318491142 CHEMBL3394106 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373902 CCOC(=O)\C=C/Sc1nc(c([nH]1)-c1ccnc(Nc2ccccc2)c1)-c1ccc(F)cc1 InChI=1S/C25H21FN4O2S/c1-2-32-22(31)13-15-33-25-29-23(17-8-10-19(26)11-9-17)24(30-25)18-12-14-27-21(16-18)28-20-6-4-3-5-7-20/h3-16H,2H2,1H3,(H,27,28)(H,29,30)/b15-13- IVUHAOSDDKKRTF-SQFISAMPSA-N 50103130 CHEMBL3394126 Mitogen-activated protein kinase 10 Homo sapiens 80 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103130&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725916 103999474 CHEMBL3394126 ZINC26261823 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50378456 CNc1ncnc(n1)-c1cccnc1Oc1cc(NC(=O)c2cccc(OC(F)(F)C(F)F)c2)ccc1C InChI=1S/C25H20F4N6O3/c1-14-8-9-16(34-21(36)15-5-3-6-17(11-15)38-25(28,29)23(26)27)12-19(14)37-22-18(7-4-10-31-22)20-32-13-33-24(30-2)35-20/h3-13,23H,1-2H3,(H,34,36)(H,30,32,33,35) GHRNBCMJJKMYNR-UHFFFAOYSA-N 50207854 CHEMBL246356::N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(1,1,2,2-tetrafluoroethoxy)benzamide Mitogen-activated protein kinase 10 Homo sapiens 40000 ChEMBL 10.1016/j.bmcl.2007.02.067 10.7270/Q2445M4C 17350837 Hodous, BL; Geuns-Meyer, SD; Hughes, PE; Albrecht, BK; Bellon, S; Caenepeel, S; Cee, VJ; Chaffee, SC; Emery, M; Fretland, J; Gallant, P; Gu, Y; Johnson, RE; Kim, JL; Long, AM; Morrison, M; Olivieri, PR; Patel, VF; Polverino, A; Rose, P; Wang, L; Zhao, H Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50207854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50207854&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 17748275 104085170 CHEMBL246356 ZINC28896926 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50374346 Fc1ccc(Br)cc1-c1nc(Nc2ccncc2C(=O)NCCCN2CCCC2=O)c2nccnc2n1 InChI=1S/C25H22BrFN8O2/c26-15-4-5-18(27)16(13-15)22-33-23-21(29-9-10-30-23)24(34-22)32-19-6-8-28-14-17(19)25(37)31-7-2-12-35-11-1-3-20(35)36/h4-6,8-10,13-14H,1-3,7,11-12H2,(H,31,37)(H,28,30,32,33,34) GZOYOEIHAGHGFM-UHFFFAOYSA-N 50204832 4-(2-(5-bromo-2-fluorophenyl)pteridin-4-ylamino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)nicotinamide::CHEMBL234655 Mitogen-activated protein kinase 10 Homo sapiens 59 ChEMBL 10.1016/j.bmcl.2007.01.046 10.7270/Q2JM2999 17289388 Raboisson, P; Lenz, O; Lin, TI; Surleraux, D; Chakravarty, S; Scholliers, A; Vermeiren, K; Delouvroy, F; Verbinnen, T; Simmen, K Tibotec BVBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50204832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50204832&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11955790 104083353 CHEMBL234655 ZINC28822268 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373721 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1CC1CCCCC1)-c1ccc(F)cc1 InChI=1S/C26H27FN4O3S/c1-17(32)29-22-15-20(11-13-28-22)25-24(19-7-9-21(27)10-8-19)30-26(35-14-12-23(33)34)31(25)16-18-5-3-2-4-6-18/h7-15,18H,2-6,16H2,1H3,(H,33,34)(H,28,29,32)/b14-12- ZGDGIGKBBZVIEF-OWBHPGMISA-N 50102911 CHEMBL3394107 Mitogen-activated protein kinase 10 Homo sapiens 25 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102911&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725898 103999276 CHEMBL3394107 ZINC13478440 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373722 CC(=O)Nc1cc(ccn1)-c1c(nc(SC2CCC(CC2O)C(O)=O)n1C1CCCCC1)-c1ccc(F)cc1 InChI=1S/C29H33FN4O4S/c1-17(35)32-25-16-19(13-14-31-25)27-26(18-7-10-21(30)11-8-18)33-29(34(27)22-5-3-2-4-6-22)39-24-12-9-20(28(37)38)15-23(24)36/h7-8,10-11,13-14,16,20,22-24,36H,2-6,9,12,15H2,1H3,(H,37,38)(H,31,32,35) ZNXYLXPOVFQCEW-UHFFFAOYSA-N 50102912 CHEMBL3394110 Mitogen-activated protein kinase 10 Homo sapiens 79 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102912&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725901 103999277 CHEMBL3394110 ZINC13478446 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373728 CC(=O)CSc1nc(c(-c2ccnc(NC(C)=O)c2)n1C)-c1ccc(F)cc1 InChI=1S/C20H19FN4O2S/c1-12(26)11-28-20-24-18(14-4-6-16(21)7-5-14)19(25(20)3)15-8-9-22-17(10-15)23-13(2)27/h4-10H,11H2,1-3H3,(H,22,23,27) QWWPWWKJOUHOAP-UHFFFAOYSA-N 50102919 CHEMBL3394097 Mitogen-activated protein kinase 10 Homo sapiens 255 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102919&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725889 103999284 CHEMBL3394097 ZINC13478444 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373729 COC(Cn1c(SC2CCC(CC2O)C(O)=O)nc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1)OC InChI=1S/C27H31FN4O6S/c1-15(33)30-22-13-17(10-11-29-22)25-24(16-4-7-19(28)8-5-16)31-27(32(25)14-23(37-2)38-3)39-21-9-6-18(26(35)36)12-20(21)34/h4-5,7-8,10-11,13,18,20-21,23,34H,6,9,12,14H2,1-3H3,(H,35,36)(H,29,30,33) QRBCLMPGNQXVQO-UHFFFAOYSA-N 50102920 CHEMBL3394112 Mitogen-activated protein kinase 10 Homo sapiens 2010 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102920&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725903 103999285 CHEMBL3394112 ZINC26177156 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373730 CC(=O)Nc1cc(ccn1)-c1c(nc(SC2CCC(CC2O)C(O)=O)n1CC1CCCO1)-c1ccc(F)cc1 InChI=1S/C28H31FN4O5S/c1-16(34)31-24-14-18(10-11-30-24)26-25(17-4-7-20(29)8-5-17)32-28(33(26)15-21-3-2-12-38-21)39-23-9-6-19(27(36)37)13-22(23)35/h4-5,7-8,10-11,14,19,21-23,35H,2-3,6,9,12-13,15H2,1H3,(H,36,37)(H,30,31,34) IMDLEWGYIJSJML-UHFFFAOYSA-N 50102921 CHEMBL3394113 Mitogen-activated protein kinase 10 Homo sapiens 2633 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102921&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725904 103999286 CHEMBL3394113 ZINC13478451 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373731 CCOC(=O)\C=C\Sc1nc(c(-c2ccnc(NC(C)=O)c2)n1C1CC1)-c1ccc(F)cc1 InChI=1S/C24H23FN4O3S/c1-3-32-21(31)11-13-33-24-28-22(16-4-6-18(25)7-5-16)23(29(24)19-8-9-19)17-10-12-26-20(14-17)27-15(2)30/h4-7,10-14,19H,3,8-9H2,1-2H3,(H,26,27,30)/b13-11+ ZJRIWXARVRPGQC-ACCUITESSA-N 50102922 CHEMBL3394114 Mitogen-activated protein kinase 10 Homo sapiens 678 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102922&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725905 103999287 CHEMBL3394114 ZINC26170816 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373732 CCOC(=O)\C=C\Sc1nc(c(-c2ccnc(NC(C)=O)c2)n1CC(OC)OC)-c1ccc(F)cc1 InChI=1S/C25H27FN4O5S/c1-5-35-21(32)11-13-36-25-29-23(17-6-8-19(26)9-7-17)24(30(25)15-22(33-3)34-4)18-10-12-27-20(14-18)28-16(2)31/h6-14,22H,5,15H2,1-4H3,(H,27,28,31)/b13-11+ CQGOMTMYTOAMCP-ACCUITESSA-N 50102933 CHEMBL3394115 Mitogen-activated protein kinase 10 Homo sapiens 2167 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102933&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725906 318491123 CHEMBL3394115 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373733 CCOC(=O)\C=C\Sc1nc(c(-c2ccnc(NC(C)=O)c2)n1CC1CC1)-c1ccc(F)cc1 InChI=1S/C25H25FN4O3S/c1-3-33-22(32)11-13-34-25-29-23(18-6-8-20(26)9-7-18)24(30(25)15-17-4-5-17)19-10-12-27-21(14-19)28-16(2)31/h6-14,17H,3-5,15H2,1-2H3,(H,27,28,31)/b13-11+ SUHMGFPSMXQUNJ-ACCUITESSA-N 50102916 CHEMBL3394116 Mitogen-activated protein kinase 10 Homo sapiens 1216 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102916&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725907 103999281 CHEMBL3394116 ZINC13478456 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373735 CC(=O)Nc1cc(ccn1)-c1c(nc(Sc2cccc(I)n2)n1C1CCCCC1)-c1ccc(F)cc1 InChI=1S/C27H25FIN5OS/c1-17(35)31-23-16-19(14-15-30-23)26-25(18-10-12-20(28)13-11-18)33-27(34(26)21-6-3-2-4-7-21)36-24-9-5-8-22(29)32-24/h5,8-16,21H,2-4,6-7H2,1H3,(H,30,31,35) GCKKLKCOSMLACG-UHFFFAOYSA-N 50102918 CHEMBL3394118 Mitogen-activated protein kinase 10 Homo sapiens 1528 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102918&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725909 103999283 CHEMBL3394118 ZINC13478449 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373736 CC(=O)Nc1cc(ccn1)-c1c(nc(SCC(O)=O)n1C)-c1ccc(F)cc1 InChI=1S/C19H17FN4O3S/c1-11(25)22-15-9-13(7-8-21-15)18-17(12-3-5-14(20)6-4-12)23-19(24(18)2)28-10-16(26)27/h3-9H,10H2,1-2H3,(H,26,27)(H,21,22,25) RAHONVSVCITSAN-UHFFFAOYSA-N 50102998 CHEMBL3394096 Mitogen-activated protein kinase 10 Homo sapiens 266 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102998&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725888 318491125 CHEMBL3394096 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373737 CC(=O)Nc1cc(ccn1)-c1c(nc(SCCC(O)=O)n1C)-c1ccc(F)cc1 InChI=1S/C20H19FN4O3S/c1-12(26)23-16-11-14(7-9-22-16)19-18(13-3-5-15(21)6-4-13)24-20(25(19)2)29-10-8-17(27)28/h3-7,9,11H,8,10H2,1-2H3,(H,27,28)(H,22,23,26) DQAXOJBNTQVNHJ-UHFFFAOYSA-N 50102913 CHEMBL3394098 Mitogen-activated protein kinase 10 Homo sapiens 91 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102913&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725890 103999278 CHEMBL3394098 ZINC13478452 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373738 COC(Cn1c(SCC#N)nc(c1-c1ccnc(F)c1)-c1ccc(F)cc1)OC InChI=1S/C20H18F2N4O2S/c1-27-17(28-2)12-26-19(14-7-9-24-16(22)11-14)18(25-20(26)29-10-8-23)13-3-5-15(21)6-4-13/h3-7,9,11,17H,10,12H2,1-2H3 BTRBVRUVAKEYKS-UHFFFAOYSA-N 50102999 CHEMBL3394093 Mitogen-activated protein kinase 10 Homo sapiens 4220 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102999&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725885 318491126 CHEMBL3394093 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373741 COC(Cn1c(SCCC(O)=O)nc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1)OC InChI=1S/C23H25FN4O5S/c1-14(29)26-18-12-16(8-10-25-18)22-21(15-4-6-17(24)7-5-15)27-23(34-11-9-19(30)31)28(22)13-20(32-2)33-3/h4-8,10,12,20H,9,11,13H2,1-3H3,(H,30,31)(H,25,26,29) UXPFOGYZAHSDQV-UHFFFAOYSA-N 50102914 CHEMBL3394099 Mitogen-activated protein kinase 10 Homo sapiens 269 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102914&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725891 103999279 CHEMBL3394099 ZINC26181519 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373742 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1C)-c1ccc(F)cc1 InChI=1S/C20H17FN4O3S/c1-12(26)23-16-11-14(7-9-22-16)19-18(13-3-5-15(21)6-4-13)24-20(25(19)2)29-10-8-17(27)28/h3-11H,1-2H3,(H,27,28)(H,22,23,26)/b10-8- CEUMJZPOGFBDDM-NTMALXAHSA-N 50103002 CHEMBL3394100 Mitogen-activated protein kinase 10 Homo sapiens 55 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103002&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725892 318491129 CHEMBL3394100 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373761 COC(Cn1c(SCC#N)nc(c1-c1ccnc(NC2CC2)c1)-c1ccc(F)cc1)OC InChI=1S/C23H24FN5O2S/c1-30-20(31-2)14-29-22(16-9-11-26-19(13-16)27-18-7-8-18)21(28-23(29)32-12-10-25)15-3-5-17(24)6-4-15/h3-6,9,11,13,18,20H,7-8,12,14H2,1-2H3,(H,26,27) PZILHQVGAVFRNS-UHFFFAOYSA-N 50103003 CHEMBL3394119 Mitogen-activated protein kinase 10 Homo sapiens 79 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103003&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725910 318491130 CHEMBL3394119 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373762 COC(Cn1c(S\C=C/C(O)=O)nc(c1-c1ccnc(NC2CC2)c1)-c1ccc(F)cc1)OC InChI=1S/C24H25FN4O4S/c1-32-21(33-2)14-29-23(16-9-11-26-19(13-16)27-18-7-8-18)22(15-3-5-17(25)6-4-15)28-24(29)34-12-10-20(30)31/h3-6,9-13,18,21H,7-8,14H2,1-2H3,(H,26,27)(H,30,31)/b12-10- DIPZBRONJOMUFV-BENRWUELSA-N 50103004 CHEMBL3394120 Mitogen-activated protein kinase 10 Homo sapiens 12 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103004&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725911 318491131 CHEMBL3394120 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373771 COC(Cn1c(S\C=C/C(O)=O)nc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1)OC InChI=1S/C23H23FN4O5S/c1-14(29)26-18-12-16(8-10-25-18)22-21(15-4-6-17(24)7-5-15)27-23(34-11-9-19(30)31)28(22)13-20(32-2)33-3/h4-12,20H,13H2,1-3H3,(H,30,31)(H,25,26,29)/b11-9- QJLJKYOXNJDYMM-LUAWRHEFSA-N 50102997 CHEMBL3394101 Mitogen-activated protein kinase 10 Homo sapiens 33 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102997&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725893 318491124 CHEMBL3394101 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373775 CCC(C)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1CC(OC)OC)-c1ccc(F)cc1 InChI=1S/C25H29FN4O4S/c1-5-16(2)28-20-14-18(10-12-27-20)24-23(17-6-8-19(26)9-7-17)29-25(35-13-11-21(31)32)30(24)15-22(33-3)34-4/h6-14,16,22H,5,15H2,1-4H3,(H,27,28)(H,31,32)/b13-11- CPLDEGFBMDVVMO-QBFSEMIESA-N 50103006 CHEMBL3394121 Mitogen-activated protein kinase 10 Homo sapiens 26 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103006&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 101913691 318491133 CHEMBL3394121 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373776 CCNC(=O)N1CCC(CC1)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1C)-c1ccc(F)cc1 InChI=1S/C26H29FN6O3S/c1-3-28-25(36)33-13-9-20(10-14-33)30-21-16-18(8-12-29-21)24-23(17-4-6-19(27)7-5-17)31-26(32(24)2)37-15-11-22(34)35/h4-8,11-12,15-16,20H,3,9-10,13-14H2,1-2H3,(H,28,36)(H,29,30)(H,34,35)/b15-11- IFQKWVFKEBTLIM-PTNGSMBKSA-N 50103007 CHEMBL3394122 Mitogen-activated protein kinase 10 Homo sapiens 61 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103007&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725912 318491134 CHEMBL3394122 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373794 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1C1CCCC1)-c1ccc(F)cc1 InChI=1S/C24H23FN4O3S/c1-15(30)27-20-14-17(10-12-26-20)23-22(16-6-8-18(25)9-7-16)28-24(33-13-11-21(31)32)29(23)19-4-2-3-5-19/h6-14,19H,2-5H2,1H3,(H,31,32)(H,26,27,30)/b13-11- BBAVPRQJJGDYDV-QBFSEMIESA-N 50103005 CHEMBL3394104 Mitogen-activated protein kinase 10 Homo sapiens 45 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103005&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725896 318491132 CHEMBL3394104 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50376989 CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1 InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3 BOCQIRYQTWRJMD-UHFFFAOYSA-N 50206421 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole::4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)pyridine::4-[3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl]pyridine::CHEMBL220227 Mitogen-activated protein kinase 10 Homo sapiens 540 ChEMBL 10.1021/jm061097o 10.7270/Q2QZ29NS 17323937 Peifer, C; Kinkel, K; Abadleh, M; Schollmeyer, D; Laufer, S Eberhard-Karls-University Tübingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206421&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16115351 104084501 CHEMBL220227 ZINC35271649 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50376991 Fc1ccc(cc1)-c1c(-c2ccncc2)c(=O)[nH]c2ccccc12 InChI=1S/C20H13FN2O/c21-15-7-5-13(6-8-15)18-16-3-1-2-4-17(16)23-20(24)19(18)14-9-11-22-12-10-14/h1-12H,(H,23,24) BCPJXIHLEGELNA-UHFFFAOYSA-N 50206420 4-(4-fluorophenyl)-3-pyridin-4-ylquinoline-2(1H)-one::CHEMBL221164 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm061097o 10.7270/Q2QZ29NS 17323937 Peifer, C; Kinkel, K; Abadleh, M; Schollmeyer, D; Laufer, S Eberhard-Karls-University Tübingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206420&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16115350 104084500 CHEMBL221164 ZINC35271645 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50376996 CS(=O)c1ccccc1CSc1ncc(-c2ccc(F)cc2)c(n1)-c1ccncc1 InChI=1S/C23H18FN3OS2/c1-30(28)21-5-3-2-4-18(21)15-29-23-26-14-20(16-6-8-19(24)9-7-16)22(27-23)17-10-12-25-13-11-17/h2-14H,15H2,1H3 VIGHOCFNNZKRLV-UHFFFAOYSA-N 50114691 2-(2-(methylsulfinyl)benzylthio)-5-(4-fluorophenyl)-4-(pyridin-4-yl)pyrimidine::5-(4-Fluoro-phenyl)-2-(2-methanesulfinyl-benzylsulfanyl)-4-pyridin-4-yl-pyrimidine::CHEMBL441811 Mitogen-activated protein kinase 10 Homo sapiens 28500 ChEMBL 10.1021/jm061097o 10.7270/Q2QZ29NS 17323937 Peifer, C; Kinkel, K; Abadleh, M; Schollmeyer, D; Laufer, S Eberhard-Karls-University Tübingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114691&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10094511 104008762 CHEMBL441811 ZINC13474290 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50376997 CC(C)c1noc(c1-c1ccncc1)-c1ccc(F)cc1 InChI=1S/C17H15FN2O/c1-11(2)16-15(12-7-9-19-10-8-12)17(21-20-16)13-3-5-14(18)6-4-13/h3-11H,1-2H3 AAQCZWGHNUPNMG-UHFFFAOYSA-N 50206423 4-(5-(4-fluorophenyl)-3-isopropylisoxazol-4-yl)pyridine::4-[5-(4-fluorophenyl)-3-isopropylisoxazol-4-yl]pyridine::5-(4-fluorophenyl)-3-isopropyl-4-(pyridin-4-yl)isoxazole::CHEMBL375428 Mitogen-activated protein kinase 10 Homo sapiens 3500 ChEMBL 10.1021/jm061097o 10.7270/Q2QZ29NS 17323937 Peifer, C; Kinkel, K; Abadleh, M; Schollmeyer, D; Laufer, S Eberhard-Karls-University Tübingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206423&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16115352 104084503 CHEMBL375428 ZINC35271652 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50376998 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 10 Homo sapiens 790 ChEMBL 10.1021/jm061097o 10.7270/Q2QZ29NS 17323937 Peifer, C; Kinkel, K; Abadleh, M; Schollmeyer, D; Laufer, S Eberhard-Karls-University Tübingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373808 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1CC1CCCO1)-c1ccc(F)cc1 InChI=1S/C24H23FN4O4S/c1-15(30)27-20-13-17(8-10-26-20)23-22(16-4-6-18(25)7-5-16)28-24(34-12-9-21(31)32)29(23)14-19-3-2-11-33-19/h4-10,12-13,19H,2-3,11,14H2,1H3,(H,31,32)(H,26,27,30)/b12-9- MSQAJMDTOWUMOF-XFXZXTDPSA-N 50103010 CHEMBL3394108 Mitogen-activated protein kinase 10 Homo sapiens 35 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103010&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725899 318491137 CHEMBL3394108 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373824 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1CC(O)CO)-c1ccc(F)cc1 InChI=1S/C22H21FN4O5S/c1-13(29)25-18-10-15(6-8-24-18)21-20(14-2-4-16(23)5-3-14)26-22(33-9-7-19(31)32)27(21)11-17(30)12-28/h2-10,17,28,30H,11-12H2,1H3,(H,31,32)(H,24,25,29)/b9-7- ZFONSHFOHVPFKD-CLFYSBASSA-N 50103011 CHEMBL3394109 Mitogen-activated protein kinase 10 Homo sapiens 226 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103011&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725900 318491138 CHEMBL3394109 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50373856 CC(=O)Nc1cc(ccn1)-c1c(nc(SC2CCC(CC2O)C(O)=O)n1C)-c1ccc(F)cc1 InChI=1S/C24H25FN4O4S/c1-13(30)27-20-12-15(9-10-26-20)22-21(14-3-6-17(25)7-4-14)28-24(29(22)2)34-19-8-5-16(23(32)33)11-18(19)31/h3-4,6-7,9-10,12,16,18-19,31H,5,8,11H2,1-2H3,(H,32,33)(H,26,27,30) OOLTXYZDVJJMMZ-UHFFFAOYSA-N 50103009 CHEMBL3394111 Mitogen-activated protein kinase 10 Homo sapiens 180 ChEMBL 10.1021/jm501557a 10.7270/Q2RN39MX 25475894 Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103009&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118725902 318491136 CHEMBL3394111 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383505 COc1ccccc1Nc1cc(ccn1)-c1ccnc(Nc2ccccc2OC)c1 InChI=1S/C24H22N4O2/c1-29-21-9-5-3-7-19(21)27-23-15-17(11-13-25-23)18-12-14-26-24(16-18)28-20-8-4-6-10-22(20)30-2/h3-16H,1-2H3,(H,25,27)(H,26,28) BEJCWWBEHHBUTJ-UHFFFAOYSA-N 50178826 CHEMBL437706::N-(2-methoxyphenyl)-4-(2-(2-methoxyphenylamino)pyridin-4-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 528 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178826&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10475988 104064099 CHEMBL437706 ZINC28570283 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383506 COc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1 InChI=1S/C22H19N5OS/c1-28-16-8-6-15(7-9-16)10-12-24-22-25-13-11-18(27-22)17(14-23)21-26-19-4-2-3-5-20(19)29-21/h2-9,11,13,17H,10,12H2,1H3,(H,24,25,27) HBTSXWZMVSDRCN-UHFFFAOYSA-N 50169995 2-(2-(4-methoxyphenethylamino)pyrimidin-4-yl)-2-(benzo[d]thiazol-2(3H)-ylidene)acetonitrile::CHEMBL370516::[3H-Benzothiazol-(2Z)-ylidene]-{2-[2-(4-methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-acetonitrile Mitogen-activated protein kinase 10 Homo sapiens 3.1 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169995&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11200442 104054743 CHEMBL370516 ZINC13647771 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383507 CCCCCCCCCCCc1cc(O)cc(O)c1C(=O)OC(CCC)CCCCCCCc1cc(OS(O)(=O)=O)cc(OS(O)(=O)=O)c1 InChI=1S/C35H54O12S2/c1-3-5-6-7-8-9-10-13-16-20-28-24-29(36)25-33(37)34(28)35(38)45-30(18-4-2)21-17-14-11-12-15-19-27-22-31(46-48(39,40)41)26-32(23-27)47-49(42,43)44/h22-26,30,36-37H,3-21H2,1-2H3,(H,39,40,41)(H,42,43,44) XOHABRRTQMIREI-UHFFFAOYSA-N 50211297 11-(3,5-bis(sulfooxy)phenyl)undecan-4-yl 2,4-dihydroxy-6-undecylbenzoate::CHEMBL254858 Mitogen-activated protein kinase 10 Homo sapiens 500 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211297&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10372770 104087495 CHEMBL254858 C02000 ZINC31706045 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383508 Clc1ccc(cc1)C(=O)NCc1ccc(s1)S(=O)(=O)N1CCC(CC1)n1nnc2ccccc12 InChI=1S/C23H22ClN5O3S2/c24-17-7-5-16(6-8-17)23(30)25-15-19-9-10-22(33-19)34(31,32)28-13-11-18(12-14-28)29-21-4-2-1-3-20(21)26-27-29/h1-10,18H,11-15H2,(H,25,30) XLVWDHAXEFKTIB-UHFFFAOYSA-N 50158551 CHEMBL383955::N-((5-(4-(1H-benzo[d][1,2,3]triazol-1-yl)piperidin-1-ylsulfonyl)thiophen-2-yl)methyl)-4-chlorobenzamide::N-5-4-1H-benzo[d][1,2,3]triazol-1-yl)piperidin-1-ylsulfonyl)thiophen-2-yl)methyl)-4-chlorobenzamide Mitogen-activated protein kinase 10 Homo sapiens 150 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50158551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50158551&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9892736 104045242 CHEMBL383955 ZINC01493969 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383509 N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1 InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) RCYPVQCPYKNSTG-UHFFFAOYSA-N 50169959 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile::AS-601245::AS601245::CHEMBL1788116::CHEMBL191384::[3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169959&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JN5 3CY3 10109823 104054707 CHEMBL1788116CHEMBL191384 5997 ZINC13647791 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383510 Cc1cnc(cn1)C(=O)Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1 InChI=1S/C22H18N6O/c1-15-13-26-19(14-25-15)22(29)28-21-12-17(8-10-24-21)16-7-9-23-20(11-16)27-18-5-3-2-4-6-18/h2-14H,1H3,(H,23,27)(H,24,28,29) QCQCMNUQTMIKHU-UHFFFAOYSA-N 50178844 5-methyl-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)pyrazine-2-carboxamide::CHEMBL205402 Mitogen-activated protein kinase 10 Homo sapiens 33 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178844&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10091293 104064117 CHEMBL205402 ZINC28571285 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383511 O=C(Nc1ccc2[nH]nc(-c3cc4ccccc4s3)c2c1)C1CCOC1 InChI=1S/C20H17N3O2S/c24-20(13-7-8-25-11-13)21-14-5-6-16-15(10-14)19(23-22-16)18-9-12-3-1-2-4-17(12)26-18/h1-6,9-10,13H,7-8,11H2,(H,21,24)(H,22,23) XDCZGBKFCLBOAX-UHFFFAOYSA-N 50211298 CHEMBL400054::N-(3-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-tetrahydrofuran-3-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 52 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211298&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 22261071 104087496 CHEMBL400054 ZINC28966672 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383512 Fc1ccc(Nc2cc(ccn2)-c2ccnc(Nc3ccc(F)cc3)c2)cc1 InChI=1S/C22H16F2N4/c23-17-1-5-19(6-2-17)27-21-13-15(9-11-25-21)16-10-12-26-22(14-16)28-20-7-3-18(24)4-8-20/h1-14H,(H,25,27)(H,26,28) PVQXGVSFLRLNTD-UHFFFAOYSA-N 50178848 CHEMBL205672::N-(4-fluorophenyl)-4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 17 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178848&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10452031 104064121 CHEMBL205672 ZINC28571291 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383513 Fc1ccc(Nc2cc(ccn2)-c2ccnc(NC(=O)[C@H]3CCOC3)c2)cc1 InChI=1S/C21H19FN4O2/c22-17-1-3-18(4-2-17)25-19-11-14(5-8-23-19)15-6-9-24-20(12-15)26-21(27)16-7-10-28-13-16/h1-6,8-9,11-12,16H,7,10,13H2,(H,23,25)(H,24,26,27)/t16-/m0/s1 DGTWHZKHMUDXOY-INIZCTEOSA-N 50211299 (3S)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide::CHEMBL252763 Mitogen-activated protein kinase 10 Homo sapiens 3 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211299&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444992 104087497 CHEMBL252763 ZINC28571307 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383514 Fc1ccc(cc1)-c1nc2CC[C@@H](Cn3ccnc3)n2c1-c1ccnc(NC2CCC2)n1 InChI=1S/C24H24FN7/c25-17-6-4-16(5-7-17)22-23(20-10-11-27-24(29-20)28-18-2-1-3-18)32-19(8-9-21(32)30-22)14-31-13-12-26-15-31/h4-7,10-13,15,18-19H,1-3,8-9,14H2,(H,27,28,29)/t19-/m0/s1 PSMXUCRLVJTKLX-IBGZPJMESA-N 50211300 4-((S)-5-((1H-imidazol-1-yl)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)-N-cyclobutylpyrimidin-2-amine::CHEMBL252762 Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211300&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444991 104087498 CHEMBL252762 ZINC28966662 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383515 N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cnc[nH]2)n1 InChI=1S/C18H15N7S/c19-9-13(17-24-15-3-1-2-4-16(15)26-17)14-6-8-22-18(25-14)21-7-5-12-10-20-11-23-12/h1-4,6,8,10-11,13H,5,7H2,(H,20,23)(H,21,22,25) ZXQRSRUXXGBKRC-UHFFFAOYSA-N 50169998 CHEMBL191581::CHEMBL254651::[3H-Benzothiazol-(2Z)-ylidene]-{2-[2-(1H-imidazol-4-yl)-ethylamino]-pyrimidin-4-yl}-acetonitrile Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169998&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10269964 104054746 CHEMBL254651CHEMBL191581 ZINC13647783 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383516 Oc1c2cccc3[nH][nH]c(c23)c2ccccc12 InChI=1S/C14H10N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,15-17H BRKXAADNUXOTJZ-UHFFFAOYSA-N 50211302 5a,10c-Dihydro-2H-dibenzo[cd,g]indazol-6-one::CHEMBL252761 Mitogen-activated protein kinase 10 Homo sapiens 190 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211302&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10398628 104087500 CHEMBL252761 ZINC28966658 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383517 CCCn1c(nc(c1-c1ccnc(NC2CC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCN(C)CC1 InChI=1S/C25H30Cl2N6/c1-3-12-33-23(21-8-11-28-25(30-21)29-18-5-6-18)22(17-4-7-19(26)20(27)15-17)31-24(33)16-9-13-32(2)14-10-16/h4,7-8,11,15-16,18H,3,5-6,9-10,12-14H2,1-2H3,(H,28,29,30) XCTKFTOEAKJMII-UHFFFAOYSA-N 16015 CHEMBL252967::N-cyclopropyl-4-[4-(3,4-dichlorophenyl)-2-(1-methylpiperidin-4-yl)-1-propyl-1H-imidazol-5-yl]pyrimidin-2-amine::imidazole-pyrimidine compound 1 Mitogen-activated protein kinase 10 Homo sapiens 1.6 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16015&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 984 1PMN 447872 46516284 CHEMBL252967 DB03084 ZINC12153007 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383518 COc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1ccccc1 InChI=1S/C20H17N3O/c1-24-19-10-6-5-9-17(19)21-15-11-12-16-18(13-15)22-23-20(16)14-7-3-2-4-8-14/h2-13,21H,1H3,(H,22,23) ZOKHEOBWAYOYGR-UHFFFAOYSA-N 50211303 (2-Methoxy-phenyl)-(3-phenyl-1H-indazol-6-yl)-amine::CHEMBL254443::N-(2-methoxyphenyl)-3-phenyl-1H-indazol-6-amine Mitogen-activated protein kinase 10 Homo sapiens 202 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211303&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10149689 104087501 CHEMBL254443 ZINC28528680 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383519 CN(C)CCNC(=O)c1ccc(cc1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12 InChI=1S/C24H24ClN5O/c1-30(2)14-13-26-24(31)17-9-7-16(8-10-17)23-19-12-11-18(15-22(19)28-29-23)27-21-6-4-3-5-20(21)25/h3-12,15,27H,13-14H2,1-2H3,(H,26,31)(H,28,29) WPHLFVIDUSHWHQ-UHFFFAOYSA-N 50211306 4-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(2-(dimethylamino)ethyl)benzamide::4-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-N-(2-dimethylamino-ethyl)-benzamide::CHEMBL399167 Mitogen-activated protein kinase 10 Homo sapiens 1.9 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211306&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10310219 104087504 CHEMBL399167 ZINC28529003 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383520 NC1=C2C3C(SN=C3c3ccccc3C2=O)=CC1 InChI=1S/C14H10N2OS/c15-9-5-6-10-12-11(9)14(17)8-4-2-1-3-7(8)13(12)16-18-10/h1-4,6,12H,5,15H2 BHINVCRNBPXQRO-UHFFFAOYSA-N 50211305 5-amino-5aH-anthra[9,1-cd]isothiazol-6(13H)-one::CHEMBL253174 Mitogen-activated protein kinase 10 Homo sapiens 400 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211305&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444994 104087503 CHEMBL253174 ZINC28966704 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383521 CNc1nccc(n1)C(C#N)c1nc2ccccc2s1 InChI=1S/C14H11N5S/c1-16-14-17-7-6-10(19-14)9(8-15)13-18-11-4-2-3-5-12(11)20-13/h2-7,9H,1H3,(H,16,17,19) ODCLSTIOISSVGF-UHFFFAOYSA-N 50211304 2-(benzo[d]thiazol-2-yl)-2-(2-(methylamino)pyrimidin-4-yl)acetonitrile::CHEMBL399168 Mitogen-activated protein kinase 10 Homo sapiens 950 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211304&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9814292 104087502 CHEMBL399168 ZINC28966742 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383522 NS(=O)(=O)c1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1 InChI=1S/C21H18N6O2S2/c22-13-16(20-26-18-3-1-2-4-19(18)30-20)17-10-12-25-21(27-17)24-11-9-14-5-7-15(8-6-14)31(23,28)29/h1-8,10,12,16H,9,11H2,(H2,23,28,29)(H,24,25,27) OSXMTIFMYHFUHI-UHFFFAOYSA-N 50169985 4-(2-(4-(benzo[d]thiazol-2(3H)-ylidene(cyano)methyl)pyrimidin-2-ylamino)ethyl)benzenesulfonamide::4-[2-(4-{[3H-Benzothiazol-(2Z)-ylidene]-cyano-methyl}-pyrimidin-2-ylamino)-ethyl]-benzenesulfonamide::CHEMBL363355 Mitogen-activated protein kinase 10 Homo sapiens 41 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169985&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11976549 104054733 CHEMBL363355 ZINC13647775 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50383523 Oc1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C18H12N2O/c21-15-4-1-12(2-5-15)14-9-16-17-11-19-8-7-13(17)3-6-18(16)20-10-14/h1-11,21H IUSSGTWHFMSCOY-UHFFFAOYSA-N 16017 4-(2,7-phenanthrolin-9-yl)phenol::4-(2=7-phenantrolin-9-yl)phenol::CHEMBL248643::phenantroline compound 3 Mitogen-activated protein kinase 10 Homo sapiens 590 ChEMBL 10.1016/j.bmc.2007.03.062 10.7270/Q2T43SSD 17451961 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Aureus Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16017&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9HP 1PMU 5326727 46516286 CHEMBL248643 DB03623 ZINC02047421 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384108 CCNC(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C20H23ClN6O/c1-2-22-20(28)27-9-7-13(8-10-27)25-19-24-12-16(21)18(26-19)15-11-23-17-6-4-3-5-14(15)17/h3-6,11-13,23H,2,7-10H2,1H3,(H,22,28)(H,24,25,26) ARMFMDYRYOKSOW-UHFFFAOYSA-N 50211424 4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide::4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide::CHEMBL248176 Mitogen-activated protein kinase 10 Homo sapiens 57 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211424&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search J07 2P33 16129582 104087605 CHEMBL248176 DB08005 ZINC16052346 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384122 CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1cnc2ccccn12 InChI=1S/C19H23N7O/c1-2-20-19(27)25-11-7-14(8-12-25)23-18-21-9-6-15(24-18)16-13-22-17-5-3-4-10-26(16)17/h3-6,9-10,13-14H,2,7-8,11-12H2,1H3,(H,20,27)(H,21,23,24) WWHNHBJMWMVKHQ-UHFFFAOYSA-N 50211427 4-(4-(H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide::CHEMBL246543 Mitogen-activated protein kinase 10 Homo sapiens 708 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211427&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440217 104087608 CHEMBL246543 ZINC28896461 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384136 CCNC(=O)N1CCC[C@@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C20H23ClN6O/c1-2-22-20(28)27-9-5-6-13(12-27)25-19-24-11-16(21)18(26-19)15-10-23-17-8-4-3-7-14(15)17/h3-4,7-8,10-11,13,23H,2,5-6,9,12H2,1H3,(H,22,28)(H,24,25,26)/t13-/m0/s1 YTPKEJXVUUNXRA-ZDUSSCGKSA-N 50211443 (3S)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide::CHEMBL392614 Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211443&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440221 104087624 CHEMBL392614 ZINC28896490 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384142 CCNC(=O)N1CCC(C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C19H21ClN6O/c1-2-21-19(27)26-8-7-12(11-26)24-18-23-10-15(20)17(25-18)14-9-22-16-6-4-3-5-13(14)16/h3-6,9-10,12,22H,2,7-8,11H2,1H3,(H,21,27)(H,23,24,25) WUFVFWHZRSJNAV-UHFFFAOYSA-N 50211437 3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-N-ethylpyrrolidine-1-carboxamide::CHEMBL246544 Mitogen-activated protein kinase 10 Homo sapiens 582 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211437&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440219 104087618 CHEMBL246544 ZINC28896479 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384168 CNC(=O)CN1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C20H23ClN6O/c1-22-18(28)12-27-8-6-13(7-9-27)25-20-24-11-16(21)19(26-20)15-10-23-17-5-3-2-4-14(15)17/h2-5,10-11,13,23H,6-9,12H2,1H3,(H,22,28)(H,24,25,26) YJIHRITUIVWNPX-UHFFFAOYSA-N 50211436 2-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)-N-methylacetamide::CHEMBL245336 Mitogen-activated protein kinase 10 Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211436&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440225 104087617 CHEMBL245336 ZINC28896513 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384175 CN(C)CC(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C21H25ClN6O/c1-27(2)13-19(29)28-9-7-14(8-10-28)25-21-24-12-17(22)20(26-21)16-11-23-18-6-4-3-5-15(16)18/h3-6,11-12,14,23H,7-10,13H2,1-2H3,(H,24,25,26) RJVBVUWFYMRHRI-UHFFFAOYSA-N 50211432 1-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)-2-(dimethylamino)ethanone::CHEMBL245732 Mitogen-activated protein kinase 10 Homo sapiens 120 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211432&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440229 104087613 CHEMBL245732 ZINC28896606 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384176 CCNC(=O)N1CC(C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C18H19ClN6O/c1-2-20-18(26)25-9-11(10-25)23-17-22-8-14(19)16(24-17)13-7-21-15-6-4-3-5-12(13)15/h3-8,11,21H,2,9-10H2,1H3,(H,20,26)(H,22,23,24) JOEVFNUJASIMNC-UHFFFAOYSA-N 50211425 3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-N-ethylazetidine-1-carboxamide::CHEMBL246545 Mitogen-activated protein kinase 10 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211425&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440220 104087606 CHEMBL246545 ZINC28896485 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384180 CCNC(=O)N1CCC(CC1)Nc1nccc(n1)-c1c([nH]c2ccccc12)-c1ccccc1 InChI=1S/C26H28N6O/c1-2-27-26(33)32-16-13-19(14-17-32)29-25-28-15-12-22(31-25)23-20-10-6-7-11-21(20)30-24(23)18-8-4-3-5-9-18/h3-12,15,19,30H,2,13-14,16-17H2,1H3,(H,27,33)(H,28,29,31) ZYWJPJYYTUCZHN-UHFFFAOYSA-N 50211428 CHEMBL245936::N-ethyl-4-(4-(2-phenyl-1H-indol-3-yl)pyrimidin-2-ylamino)piperidine-1-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211428&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440236 104087609 CHEMBL245936 ZINC28896656 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384187 CNC(=O)CN1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C20H23ClN6O/c1-22-18(28)12-27-8-4-5-13(11-27)25-20-24-10-16(21)19(26-20)15-9-23-17-7-3-2-6-14(15)17/h2-3,6-7,9-10,13,23H,4-5,8,11-12H2,1H3,(H,22,28)(H,24,25,26)/t13-/m1/s1 JMOMBPSAYLGZAN-CYBMUJFWSA-N 50211426 2-((R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)-N-methylacetamide::CHEMBL392615 Mitogen-activated protein kinase 10 Homo sapiens 31 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211426&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440224 104087607 CHEMBL392615 ZINC28896508 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384192 CCNC(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C20H23ClN6O/c1-2-22-20(28)27-9-5-6-13(12-27)25-19-24-11-16(21)18(26-19)15-10-23-17-8-4-3-7-14(15)17/h3-4,7-8,10-11,13,23H,2,5-6,9,12H2,1H3,(H,22,28)(H,24,25,26)/t13-/m1/s1 YTPKEJXVUUNXRA-CYBMUJFWSA-N 50211439 (3R)-3-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide::CHEMBL245335 Mitogen-activated protein kinase 10 Homo sapiens 107 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211439&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440223 104087620 CHEMBL245335 ZINC28896502 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384193 CCOC(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C20H22ClN5O2/c1-2-28-20(27)26-9-7-13(8-10-26)24-19-23-12-16(21)18(25-19)15-11-22-17-6-4-3-5-14(15)17/h3-6,11-13,22H,2,7-10H2,1H3,(H,23,24,25) VFDMQZQCLWTEJN-UHFFFAOYSA-N 50211434 CHEMBL245533::ethyl 4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidine-1-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 82 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211434&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11655237 104087615 CHEMBL245533 ZINC28896528 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384196 CCNC(=O)N1CCC(CC1)Nc1ncc(C#N)c(n1)-c1c[nH]c2cc(F)ccc12 InChI=1S/C21H22FN7O/c1-2-24-21(30)29-7-5-15(6-8-29)27-20-26-11-13(10-23)19(28-20)17-12-25-18-9-14(22)3-4-16(17)18/h3-4,9,11-12,15,25H,2,5-8H2,1H3,(H,24,30)(H,26,27,28) XVLIRDXMQGPGCW-UHFFFAOYSA-N 50211431 4-(5-cyano-4-(6-fluoro-1H-indol-3-yl)pyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide::CHEMBL248370 Mitogen-activated protein kinase 10 Homo sapiens 412 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211431&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440161 104087612 CHEMBL248370 ZINC28896068 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384198 CNCC(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C20H23ClN6O/c1-22-12-18(28)27-8-6-13(7-9-27)25-20-24-11-16(21)19(26-20)15-10-23-17-5-3-2-4-14(15)17/h2-5,10-11,13,22-23H,6-9,12H2,1H3,(H,24,25,26) BKBYGIARQARTNG-UHFFFAOYSA-N 50211446 1-(4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)-2-(methylamino)ethanone::CHEMBL393861 Mitogen-activated protein kinase 10 Homo sapiens 179 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211446&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440228 104087627 CHEMBL393861 ZINC28896599 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384203 CCNC(=O)N1CCC(CC1)Nc1ncc(C)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C21H26N6O/c1-3-22-21(28)27-10-8-15(9-11-27)25-20-24-12-14(2)19(26-20)17-13-23-18-7-5-4-6-16(17)18/h4-7,12-13,15,23H,3,8-11H2,1-2H3,(H,22,28)(H,24,25,26) UGZLJUFPCPHHSW-UHFFFAOYSA-N 50211445 4-(4-(1H-indol-3-yl)-5-methylpyrimidin-2-ylamino)-N-ethylpiperidine-1-carboxamide::CHEMBL245724 Mitogen-activated protein kinase 10 Homo sapiens 410 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211445&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11538129 104087626 CHEMBL245724 ZINC28896439 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50384210 CC1CCN(CC1)C(=O)N1CCC(CC1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C24H29ClN6O/c1-16-6-10-30(11-7-16)24(32)31-12-8-17(9-13-31)28-23-27-15-20(25)22(29-23)19-14-26-21-5-3-2-4-18(19)21/h2-5,14-17,26H,6-13H2,1H3,(H,27,28,29) KXNZPASCSDMHFQ-UHFFFAOYSA-N 50211430 (4-(5-chloro-4-(1H-indol-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)(4-methylpiperidin-1-yl)methanone::CHEMBL245733 Mitogen-activated protein kinase 10 Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2007.03.078 10.7270/Q2959H7W 17459703 Alam, M; Beevers, RE; Ceska, T; Davenport, RJ; Dickson, KM; Fortunato, M; Gowers, L; Haughan, AF; James, LA; Jones, MW; Kinsella, N; Lowe, C; Meissner, JW; Nicolas, AL; Perry, BG; Phillips, DJ; Pitt, WR; Platt, A; Ratcliffe, AJ; Sharpe, A; Tait, LJ UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211430&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44440230 104087611 CHEMBL245733 ZINC28896612 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50409851 CC(C)c1noc(c1-c1ccncc1)-c1ccc(F)cc1 InChI=1S/C17H15FN2O/c1-11(2)16-15(12-7-9-19-10-8-12)17(21-20-16)13-3-5-14(18)6-4-13/h3-11H,1-2H3 AAQCZWGHNUPNMG-UHFFFAOYSA-N 50206423 4-(5-(4-fluorophenyl)-3-isopropylisoxazol-4-yl)pyridine::4-[5-(4-fluorophenyl)-3-isopropylisoxazol-4-yl]pyridine::5-(4-fluorophenyl)-3-isopropyl-4-(pyridin-4-yl)isoxazole::CHEMBL375428 Mitogen-activated protein kinase 10 Homo sapiens 3500 ChEMBL 10.1016/j.bmcl.2007.12.073 10.7270/Q208652M 18207396 Peifer, C; Urich, R; Schattel, V; Abadleh, M; Rottig, M; Kohlbacher, O; Laufer, S Eberhard-Karls University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206423&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16115352 104084503 CHEMBL375428 ZINC35271652 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50409858 CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1 InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3 BOCQIRYQTWRJMD-UHFFFAOYSA-N 50206421 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole::4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)pyridine::4-[3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl]pyridine::CHEMBL220227 Mitogen-activated protein kinase 10 Homo sapiens 540 ChEMBL 10.1016/j.bmcl.2007.12.073 10.7270/Q208652M 18207396 Peifer, C; Urich, R; Schattel, V; Abadleh, M; Rottig, M; Kohlbacher, O; Laufer, S Eberhard-Karls University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206421&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16115351 104084501 CHEMBL220227 ZINC35271649 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402473 Oc1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C18H12N2O/c21-15-4-1-12(2-5-15)14-9-16-17-11-19-8-7-13(17)3-6-18(16)20-10-14/h1-11,21H IUSSGTWHFMSCOY-UHFFFAOYSA-N 16017 4-(2,7-phenanthrolin-9-yl)phenol::4-(2=7-phenantrolin-9-yl)phenol::CHEMBL248643::phenantroline compound 3 Mitogen-activated protein kinase 10 Homo sapiens 590 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16017&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9HP 1PMU 5326727 46516286 CHEMBL248643 DB03623 ZINC02047421 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402474 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(Nc3ncccn3)c2c1 InChI=1S/C20H17N5O2S/c1-28(26,27)25-16-8-6-14(7-9-16)15-12-17-18(23-13-15)4-2-5-19(17)24-20-21-10-3-11-22-20/h2-13,25H,1H3,(H,21,22,24) VTLAREVWFKEHIV-UHFFFAOYSA-N 50223996 CHEMBL248790::N-(4-(5-(pyrimidin-2-ylamino)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 480 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50223996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50223996&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444025 104095749 CHEMBL248790 ZINC28957604 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402475 c1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C18H12N2/c1-2-4-13(5-3-1)15-10-16-17-12-19-9-8-14(17)6-7-18(16)20-11-15/h1-12H CYWFWPAZNQOVIY-UHFFFAOYSA-N 50223997 9-phenyl-2,7-phenanthroline::CHEMBL248644 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50223997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50223997&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444010 104095750 CHEMBL248644 ZINC28957580 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402476 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(-c3ccccn3)c2c1 InChI=1S/C21H17N3O2S/c1-27(25,26)24-17-10-8-15(9-11-17)16-13-19-18(20-6-2-3-12-22-20)5-4-7-21(19)23-14-16/h2-14,24H,1H3 OUYIVOXVMOHBFA-UHFFFAOYSA-N 50224004 CHEMBL249184::N-(4-(5-(pyridin-2-yl)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224004&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444033 104095757 CHEMBL249184 ZINC28957617 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402477 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(Nc3ccc(F)cn3)c2c1 InChI=1S/C21H17FN4O2S/c1-29(27,28)26-17-8-5-14(6-9-17)15-11-18-19(23-12-15)3-2-4-20(18)25-21-10-7-16(22)13-24-21/h2-13,26H,1H3,(H,24,25) QFJZACGIDPBUBD-UHFFFAOYSA-N 50224001 CHEMBL248984::N-(4-(5-(5-fluoropyridin-2-ylamino)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224001&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444030 104095754 CHEMBL248984 ZINC28957612 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402478 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(Nc3ccccn3)c2c1 InChI=1S/C21H18N4O2S/c1-28(26,27)25-17-10-8-15(9-11-17)16-13-18-19(23-14-16)5-4-6-20(18)24-21-7-2-3-12-22-21/h2-14,25H,1H3,(H,22,24) SKWCPMOBKIPLTH-UHFFFAOYSA-N 50224000 CHEMBL401123::N-(4-(5-(pyridin-2-ylamino)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 440 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224000&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444024 104095753 CHEMBL401123 ZINC28957603 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402479 CS(=O)(=O)N(c1ccc(cc1)-c1cnc2ccc3ccncc3c2c1)S(C)(=O)=O InChI=1S/C20H17N3O4S2/c1-28(24,25)23(29(2,26)27)17-6-3-14(4-7-17)16-11-18-19-13-21-10-9-15(19)5-8-20(18)22-12-16/h3-13H,1-2H3 HJXCLQZOCKOHNJ-UHFFFAOYSA-N 50224002 CHEMBL250199::N-(methylsulfonyl)-N-[4-(2,7-phenanthrolin-9-yl)phenyl]methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224002&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444021 104095755 CHEMBL250199 ZINC28957598 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402480 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(-c3cccnc3)c2c1 InChI=1S/C21H17N3O2S/c1-27(25,26)24-18-9-7-15(8-10-18)17-12-20-19(16-4-3-11-22-13-16)5-2-6-21(20)23-14-17/h2-14,24H,1H3 FXRHCXVVSOOGRY-UHFFFAOYSA-N 50224005 CHEMBL248612::N-(4-(5-(pyridin-3-yl)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 5200 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224005&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444034 104095758 CHEMBL248612 ZINC28957618 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402481 CC(=O)Nc1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C20H15N3O/c1-13(24)23-17-5-2-14(3-6-17)16-10-18-19-12-21-9-8-15(19)4-7-20(18)22-11-16/h2-12H,1H3,(H,23,24) SBJYLYLBPXXYFA-UHFFFAOYSA-N 50224006 CHEMBL248833::N-(4-(2,7-phenanthrolin-9-yl)phenyl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 530 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224006&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444018 104095759 CHEMBL248833 ZINC28957593 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402482 NS(=O)(=O)c1ccc(cc1)-c1cnc2cccc(Nc3ccc(Cl)cn3)c2c1 InChI=1S/C20H15ClN4O2S/c21-15-6-9-20(24-12-15)25-19-3-1-2-18-17(19)10-14(11-23-18)13-4-7-16(8-5-13)28(22,26)27/h1-12H,(H,24,25)(H2,22,26,27) IRTCDXAMYIOROG-UHFFFAOYSA-N 50224008 4-(5-(5-chloropyridin-2-ylamino)quinolin-3-yl)benzenesulfonamide::CHEMBL250017 Mitogen-activated protein kinase 10 Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224008&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444039 104095761 CHEMBL250017 ZINC28957627 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402483 CC(C)(C)NS(=O)(=O)c1ccc(cc1)-c1cnc2cccc(Nc3ccccn3)c2c1 InChI=1S/C24H24N4O2S/c1-24(2,3)28-31(29,30)19-12-10-17(11-13-19)18-15-20-21(26-16-18)7-6-8-22(20)27-23-9-4-5-14-25-23/h4-16,28H,1-3H3,(H,25,27) GJTCKUKIFXWJKG-UHFFFAOYSA-N 50224009 CHEMBL250409::N-(tert-butyl)-4-[5-(pyridin-2-ylamino)quinolin-3-yl]benzenesulfonamide::N-tert-butyl-4-(5-(pyridin-2-ylamino)quinolin-3-yl)benzenesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 150 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224009&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 255 2R9S 16750106 104095762 CHEMBL250409 DB06933 ZINC16052735 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402484 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(Nc3cccc(Cl)n3)c2c1 InChI=1S/C21H17ClN4O2S/c1-29(27,28)26-16-10-8-14(9-11-16)15-12-17-18(23-13-15)4-2-5-19(17)24-21-7-3-6-20(22)25-21/h2-13,26H,1H3,(H,24,25) ZVFDDQBMECSXGC-UHFFFAOYSA-N 50224010 CHEMBL248982::N-(4-(5-(6-chloropyridin-2-ylamino)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 6500 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224010&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444029 104095763 CHEMBL248982 ZINC28957610 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402485 Nc1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C18H13N3/c19-15-4-1-12(2-5-15)14-9-16-17-11-20-8-7-13(17)3-6-18(16)21-10-14/h1-11H,19H2 BHPVRWUAWLHPOJ-UHFFFAOYSA-N 50224003 4-(2,7-phenanthrolin-9-yl)benzenamine::CHEMBL248832 Mitogen-activated protein kinase 10 Homo sapiens 510 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224003&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444014 104095756 CHEMBL248832 ZINC28957586 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402486 C1CN(CCO1)c1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C22H19N3O/c1-4-19(25-9-11-26-12-10-25)5-2-16(1)18-13-20-21-15-23-8-7-17(21)3-6-22(20)24-14-18/h1-8,13-15H,9-12H2 SKSXHKGHLRZGHK-UHFFFAOYSA-N 50224011 9-(4-morpholinophenyl)-2,7-phenanthroline::CHEMBL248831 Mitogen-activated protein kinase 10 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224011&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444013 104095764 CHEMBL248831 ZINC28957585 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402487 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(Nc3ccc(cn3)C(F)(F)F)c2c1 InChI=1S/C22H17F3N4O2S/c1-32(30,31)29-17-8-5-14(6-9-17)15-11-18-19(26-12-15)3-2-4-20(18)28-21-10-7-16(13-27-21)22(23,24)25/h2-13,29H,1H3,(H,27,28) FMZGCAUIWBCQBO-UHFFFAOYSA-N 50224013 CHEMBL398691::N-(4-(5-(5-(trifluoromethyl)pyridin-2-ylamino)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 490 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224013&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444031 104095766 CHEMBL398691 ZINC28957613 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402488 CC(C)(C)NS(=O)(=O)c1ccc(cc1)-c1cnc2cccc(Nc3ccc(Cl)cn3)c2c1 InChI=1S/C24H23ClN4O2S/c1-24(2,3)29-32(30,31)19-10-7-16(8-11-19)17-13-20-21(26-14-17)5-4-6-22(20)28-23-12-9-18(25)15-27-23/h4-15,29H,1-3H3,(H,27,28) OBLQTSBUQFNCJS-UHFFFAOYSA-N 50224007 CHEMBL430014::N-tert-butyl-4-(5-(5-chloropyridin-2-ylamino)quinolin-3-yl)benzenesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 250 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224007&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444037 104095760 CHEMBL430014 ZINC28957623 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402489 NS(=O)(=O)c1ccc(cc1)-c1cnc2cccc(Nc3ccccn3)c2c1 InChI=1S/C20H16N4O2S/c21-27(25,26)16-9-7-14(8-10-16)15-12-17-18(23-13-15)4-3-5-19(17)24-20-6-1-2-11-22-20/h1-13H,(H,22,24)(H2,21,25,26) XSTSUOAYRBITOB-UHFFFAOYSA-N 50224016 4-(5-(pyridin-2-ylamino)quinolin-3-yl)benzenesulfonamide::CHEMBL400863 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224016&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444038 104095769 CHEMBL400863 ZINC28957626 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402490 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(Nc3ncc(s3)[N+]([O-])=O)c2c1 InChI=1S/C19H15N5O4S2/c1-30(27,28)23-14-7-5-12(6-8-14)13-9-15-16(20-10-13)3-2-4-17(15)22-19-21-11-18(29-19)24(25)26/h2-11,23H,1H3,(H,21,22) VGZBYVJCYXZGHV-UHFFFAOYSA-N 50224015 CHEMBL248792::N-(4-(5-(5-nitrothiazol-2-ylamino)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 760 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224015&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444027 104095768 CHEMBL248792 ZINC28957607 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402491 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(NC(=O)c3ccccn3)c2c1 InChI=1S/C22H18N4O3S/c1-30(28,29)26-17-10-8-15(9-11-17)16-13-18-19(24-14-16)6-4-7-20(18)25-22(27)21-5-2-3-12-23-21/h2-14,26H,1H3,(H,25,27) UDBGVXBZSGHAOV-UHFFFAOYSA-N 50224012 CHEMBL248791::N-(3-(4-(methylsulfonamido)phenyl)quinolin-5-yl)picolinamide Mitogen-activated protein kinase 10 Homo sapiens 3600 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224012&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444026 104095765 CHEMBL248791 ZINC28957605 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402492 c1cc(n[nH]1)-c1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C21H14N4/c1-3-16(20-8-10-24-25-20)4-2-14(1)17-11-18-19-13-22-9-7-15(19)5-6-21(18)23-12-17/h1-13H,(H,24,25) LVJMNNYTECXKCH-UHFFFAOYSA-N 50224018 9-(4-(1H-pyrazol-5-yl)phenyl)-2,7-phenanthroline::CHEMBL248830 Mitogen-activated protein kinase 10 Homo sapiens 3600 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444012 104095771 CHEMBL248830 ZINC28957584 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402493 c1ccc(cc1)-c1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C24H16N2/c1-2-4-17(5-3-1)18-6-8-19(9-7-18)21-14-22-23-16-25-13-12-20(23)10-11-24(22)26-15-21/h1-16H CXNCGBGJMAZVQS-UHFFFAOYSA-N 50224017 9-biphenyl-4-yl-[2,7]phenanthroline::CHEMBL403572 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224017&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444011 104095770 CHEMBL403572 ZINC28957582 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402494 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(Nc3ccc(Cl)cn3)c2c1 InChI=1S/C21H17ClN4O2S/c1-29(27,28)26-17-8-5-14(6-9-17)15-11-18-19(23-12-15)3-2-4-20(18)25-21-10-7-16(22)13-24-21/h2-13,26H,1H3,(H,24,25) RBEBLPVBJDMKCE-UHFFFAOYSA-N 50224014 CHEMBL248983::N-(4-(5-(5-chloropyridin-2-ylamino)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 120 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224014&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24779711 104095767 CHEMBL248983 ZINC28957611 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402495 CC(=O)N(C(C)=O)c1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C22H17N3O2/c1-14(26)25(15(2)27)19-6-3-16(4-7-19)18-11-20-21-13-23-10-9-17(21)5-8-22(20)24-12-18/h3-13H,1-2H3 YEGMZKBGTXJQMR-UHFFFAOYSA-N 50224020 CHEMBL248645::N-acetyl-N-(4-[2,7]phenanthrolin-9-yl-phenyl)-acetamide Mitogen-activated protein kinase 10 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224020&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444016 104095773 CHEMBL248645 ZINC28957589 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402496 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(Nc3ncccc3Cl)c2c1 InChI=1S/C21H17ClN4O2S/c1-29(27,28)26-16-9-7-14(8-10-16)15-12-17-19(24-13-15)5-2-6-20(17)25-21-18(22)4-3-11-23-21/h2-13,26H,1H3,(H,23,25) OVEFSTLGZKEMFM-UHFFFAOYSA-N 50224019 CHEMBL398493::N-(4-(5-(3-chloropyridin-2-ylamino)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 15000 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224019&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444028 104095772 CHEMBL398493 ZINC28957609 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402497 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2cccc(-c3ccncc3)c2c1 InChI=1S/C21H17N3O2S/c1-27(25,26)24-18-7-5-15(6-8-18)17-13-20-19(16-9-11-22-12-10-16)3-2-4-21(20)23-14-17/h2-14,24H,1H3 WAUUHYFQLCYUDP-UHFFFAOYSA-N 50223999 CHEMBL400862::N-(4-(5-(pyridin-4-yl)quinolin-3-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50223999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50223999&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444036 104095752 CHEMBL400862 ZINC28957621 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50402498 CS(=O)(=O)Nc1ccc(cc1)-c1cnc2ccc3ccncc3c2c1 InChI=1S/C19H15N3O2S/c1-25(23,24)22-16-5-2-13(3-6-16)15-10-17-18-12-20-9-8-14(18)4-7-19(17)21-11-15/h2-12,22H,1H3 ACBWHQJSKCXNTA-UHFFFAOYSA-N 50223998 CHEMBL249998::N-(4-(2,7-phenanthrolin-9-yl)phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 930 ChEMBL 10.1016/j.bmcl.2007.08.054 10.7270/Q26M36KX 17911023 Jiang, R; Duckett, D; Chen, W; Habel, J; Ling, YY; LoGrasso, P; Kamenecka, TM Scripps Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50223998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50223998&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44444019 104095751 CHEMBL249998 ZINC28957595 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50422093 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2008.06.028 10.7270/Q2JH3M0B 18602262 Angell, RM; Angell, TD; Bamborough, P; Bamford, MJ; Chung, CW; Cockerill, SG; Flack, SS; Jones, KL; Laine, DI; Longstaff, T; Ludbrook, S; Pearson, R; Smith, KJ; Smee, PA; Somers, DO; Walker, AL GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50414942 CNC(=O)CN1CCC(CC1)Nc1nccc(n1)-c1cnc2ccccn12 InChI=1S/C19H23N7O/c1-20-18(27)13-25-10-6-14(7-11-25)23-19-21-8-5-15(24-19)16-12-22-17-4-2-3-9-26(16)17/h2-5,8-9,12,14H,6-7,10-11,13H2,1H3,(H,20,27)(H,21,23,24) AJLILYAPRHIFAS-UHFFFAOYSA-N 50271524 2-(4-(4-(H-imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-ylamino)piperidin-1-yl)-N-methylacetamide::2-{4-[(4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]piperidin-1-yl}-N-methylacetamide::CHEMBL485323 Mitogen-activated protein kinase 10 Homo sapiens 270 ChEMBL 10.1016/j.bmcl.2008.04.039 10.7270/Q2NZ87FX 18482836 Buckley, GM; Ceska, TA; Fraser, JL; Gowers, L; Groom, CR; Higueruelo, AP; Jenkins, K; Mack, SR; Morgan, T; Parry, DM; Pitt, WR; Rausch, O; Richard, MD; Sabin, V UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271524&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JNO 3CGO 24801863 104116279 CHEMBL485323 DB08026 ZINC16052751 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50414946 CN(C1CCCCC1)c1nccc(n1)-c1cnc2ccccn12 InChI=1S/C18H21N5/c1-22(14-7-3-2-4-8-14)18-19-11-10-15(21-18)16-13-20-17-9-5-6-12-23(16)17/h5-6,9-14H,2-4,7-8H2,1H3 HYNNWLVWJXWXFO-UHFFFAOYSA-N 50271563 CHEMBL482708::N-cyclohexyl-4-(H-imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine::N-cyclohexyl-4-imidazo[1,2-a]pyridin-3-yl-N-methylpyrimidin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2008.04.039 10.7270/Q2NZ87FX 18482836 Buckley, GM; Ceska, TA; Fraser, JL; Gowers, L; Groom, CR; Higueruelo, AP; Jenkins, K; Mack, SR; Morgan, T; Parry, DM; Pitt, WR; Rausch, O; Richard, MD; Sabin, V UCB Pharma SA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271563&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JNF 3CGF 24801862 104116310 CHEMBL482708 DB08023 ZINC39079624 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50422619 CN(C)CCCNC(=O)c1csc2nc(cn12)-c1ccc(NC(=O)Nc2cc(on2)C(C)(C)C)cc1 InChI=1S/C25H31N7O3S/c1-25(2,3)20-13-21(30-35-20)29-23(34)27-17-9-7-16(8-10-17)18-14-32-19(15-36-24(32)28-18)22(33)26-11-6-12-31(4)5/h7-10,13-15H,6,11-12H2,1-5H3,(H,26,33)(H2,27,29,30,34) VBYMFAOTZHNONG-UHFFFAOYSA-N 50123803 CHEMBL3623375 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2015.08.068 10.7270/Q24X59MV 26342867 Lin, XD; Yang, HW; Ma, S; Li, WW; Zhang, CH; Wang, WJ; Xiang, R; Li, LL; Yang, SY Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50123803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50123803&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 122192466 104016215 CHEMBL3623375 ZINC13589966 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50430624 N#Cc1ccnc(Nc2cc(C3CCN(CC3)C3COC3)n(n2)C2CCCC2)c1 InChI=1S/C22H28N6O/c23-13-16-5-8-24-21(11-16)25-22-12-20(28(26-22)18-3-1-2-4-18)17-6-9-27(10-7-17)19-14-29-15-19/h5,8,11-12,17-19H,1-4,6-7,9-10,14-15H2,(H,24,25,26) GMTAOJMPNXLKJI-UHFFFAOYSA-N 50128294 CHEMBL3629013 Mitogen-activated protein kinase 10 Homo sapiens 2100 ChEMBL 10.1021/acs.jmedchem.5b01072 10.7270/Q27D2WZ0 26431428 Patel, S; Harris, SF; Gibbons, P; Deshmukh, G; Gustafson, A; Kellar, T; Lin, H; Liu, X; Liu, Y; Liu, Y; Ma, C; Scearce-Levie, K; Ghosh, AS; Shin, YG; Solanoy, H; Wang, J; Wang, B; Yin, J; Siu, M; Lewcock, JW WuXi AppTec Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128294&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 50F 5CEQ 91936970 104020059 CHEMBL3629013 ZINC29552518 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50441297 O=C(Nc1sc2CCCCc2c1C#N)c1ccccc1 InChI=1S/C16H14N2OS/c17-10-13-12-8-4-5-9-14(12)20-16(13)18-15(19)11-6-2-1-3-7-11/h1-3,6-7H,4-5,8-9H2,(H,18,19) OKFHWMLGUMHKFC-UHFFFAOYSA-N 50241256 CHEMBL233000::N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)benzamide Mitogen-activated protein kinase 10 Homo sapiens 1500 ChEMBL 10.1021/jm8011036 10.7270/Q2WS8T4C 19035792 Bamborough, P; Drewry, D; Harper, G; Smith, GK; Schneider, K GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241256&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 290221 104098682 CHEMBL233000 ZINC00135906 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50439214 CN(C)CCOc1cc(ccc1NC(=O)C1COc2ccccc2C1)-c1cn[nH]c1 InChI=1S/C23H26N4O3/c1-27(2)9-10-29-22-12-16(19-13-24-25-14-19)7-8-20(22)26-23(28)18-11-17-5-3-4-6-21(17)30-15-18/h3-8,12-14,18H,9-11,15H2,1-2H3,(H,24,25)(H,26,28) DNAXPHDUUNPFLH-UHFFFAOYSA-N 50256163 CHEMBL474425::N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)chroman-3-carboxamide Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2008.10.080 10.7270/Q2KK9BMC 18990570 Chen, YT; Bannister, TD; Weiser, A; Griffin, E; Lin, L; Ruiz, C; Cameron, MD; Schurer, S; Duckett, D; Schroter, T; LoGrasso, P; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256163&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25154767 104107784 CHEMBL474425 ZINC40900094 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50439219 CN(C)CCOc1cc(ccc1NC(=O)C1COc2ccc(F)cc2C1)-c1cn[nH]c1 InChI=1S/C23H25FN4O3/c1-28(2)7-8-30-22-11-15(18-12-25-26-13-18)3-5-20(22)27-23(29)17-9-16-10-19(24)4-6-21(16)31-14-17/h3-6,10-13,17H,7-9,14H2,1-2H3,(H,25,26)(H,27,29) DSPGFBKVTVUENE-UHFFFAOYSA-N 50256383 CHEMBL481545::N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-6-fluorochroman-3-carboxamide Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2008.10.080 10.7270/Q2KK9BMC 18990570 Chen, YT; Bannister, TD; Weiser, A; Griffin, E; Lin, L; Ruiz, C; Cameron, MD; Schurer, S; Duckett, D; Schroter, T; LoGrasso, P; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256383&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44571730 104107890 CHEMBL481545 ZINC40933814 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50439220 COc1ccc2OCC(Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 InChI=1S/C24H28N4O4/c1-28(2)8-9-31-23-12-16(19-13-25-26-14-19)4-6-21(23)27-24(29)18-10-17-11-20(30-3)5-7-22(17)32-15-18/h4-7,11-14,18H,8-10,15H2,1-3H3,(H,25,26)(H,27,29) ROFMCPHQNWGXGE-UHFFFAOYSA-N 50256322 CHEMBL482336::N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-6-methoxychroman-3-carboxamide Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2008.10.080 10.7270/Q2KK9BMC 18990570 Chen, YT; Bannister, TD; Weiser, A; Griffin, E; Lin, L; Ruiz, C; Cameron, MD; Schurer, S; Duckett, D; Schroter, T; LoGrasso, P; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50256322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50256322&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25262260 104107861 CHEMBL482336 ZINC40935311 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434272 Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)NC1CC1 InChI=1S/C25H29N5O2/c1-17-2-3-19(24(31)28-21-5-6-21)15-22(17)18-4-7-23-20(14-18)16-27-25(29-23)26-8-9-30-10-12-32-13-11-30/h2-4,7,14-16,21H,5-6,8-13H2,1H3,(H,28,31)(H,26,27,29) MNEXDVSJIUQQRH-UHFFFAOYSA-N 50252739 CHEMBL494072::N-Cyclopropyl-4-methyl-3-(2-((2-(4-morpholinyl)ethyl)amino)-6-quinazolinyl)benzamide::N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide Mitogen-activated protein kinase 10 Homo sapiens 788 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252739&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search P40 3DT1 24963046 104105477 CHEMBL494072 DB08351 ZINC20148990 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434327 Cc1ccccc1-c1nncc2cc(ccc12)-c1cc(ccc1C)C(=O)NC1CC1 InChI=1S/C26H23N3O/c1-16-5-3-4-6-22(16)25-23-12-9-18(13-20(23)15-27-29-25)24-14-19(8-7-17(24)2)26(30)28-21-10-11-21/h3-9,12-15,21H,10-11H2,1-2H3,(H,28,30) GQXMJOSCBRZMKE-UHFFFAOYSA-N 50253154 CHEMBL492265::N-Cyclopropyl-4-methyl-3-(1-(2-methylphenyl)-6-phthalazinyl)benzamide::N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide Mitogen-activated protein kinase 10 Homo sapiens 6626 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50253154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50253154&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search A17 3DS6 24941253 104105753 CHEMBL492265 DB07307 ZINC34285200 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434328 Cc1ccc(cc1-c1ccc2c(nncc2c1)-c1ccccc1)C(=O)NC1CC1 InChI=1S/C25H21N3O/c1-16-7-8-19(25(29)27-21-10-11-21)14-23(16)18-9-12-22-20(13-18)15-26-28-24(22)17-5-3-2-4-6-17/h2-9,12-15,21H,10-11H2,1H3,(H,27,29) LQXUFIFTFVOCHC-UHFFFAOYSA-N 50253153 CHEMBL495330::N-Cyclopropyl-4-methyl-3-(1-phenyl-6-phthalazinyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50253153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50253153&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11848567 104105752 CHEMBL495330 ZINC36475503 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434329 C[C@@H](Oc1nncc2cc(ccc12)-c1cc(ccc1C)C(=O)NC1CC1)C(F)(F)F InChI=1S/C22H20F3N3O2/c1-12-3-4-15(20(29)27-17-6-7-17)10-19(12)14-5-8-18-16(9-14)11-26-28-21(18)30-13(2)22(23,24)25/h3-5,8-11,13,17H,6-7H2,1-2H3,(H,27,29)/t13-/m1/s1 XANMCBRIKIVXBI-CYBMUJFWSA-N 50253152 CHEMBL493708::N-Cyclopropyl-4-methyl-3-(1-((R)-2,2,2-trifluoro-1-methylethoxy)-6-phthalazinyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens 9487 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50253152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50253152&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24854902 104105751 CHEMBL493708 ZINC40430376 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434330 C[C@H](Oc1nncc2cc(ccc12)-c1cc(ccc1C)C(=O)NC1CC1)C(F)(F)F InChI=1S/C22H20F3N3O2/c1-12-3-4-15(20(29)27-17-6-7-17)10-19(12)14-5-8-18-16(9-14)11-26-28-21(18)30-13(2)22(23,24)25/h3-5,8-11,13,17H,6-7H2,1-2H3,(H,27,29)/t13-/m0/s1 XANMCBRIKIVXBI-ZDUSSCGKSA-N 50252782 CHEMBL493671::N-Cyclopropyl-4-methyl-3-(1-((S)-2,2,2-trifluoro-1-methylethoxy)-6-phthalazinyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252782&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24854903 104105515 CHEMBL493671 ZINC40956459 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434331 CC(C)Oc1nncc2cc(ccc12)-c1cc(ccc1C)C(=O)NC1CC1 InChI=1S/C22H23N3O2/c1-13(2)27-22-19-9-6-15(10-17(19)12-23-25-22)20-11-16(5-4-14(20)3)21(26)24-18-7-8-18/h4-6,9-13,18H,7-8H2,1-3H3,(H,24,26) PRMZAUJLQXIACS-UHFFFAOYSA-N 50252781 CHEMBL493670::N-Cyclopropyl-4-methyl-3-(1-(1-methylethoxy)-6-phthalazinyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252781&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11848309 104105514 CHEMBL493670 ZINC36475292 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434332 O=C(NC1CC1)c1cccc(c1)-c1ccc2c(nncc2c1)N1CCOCC1 InChI=1S/C22H22N4O2/c27-22(24-19-5-6-19)17-3-1-2-15(12-17)16-4-7-20-18(13-16)14-23-25-21(20)26-8-10-28-11-9-26/h1-4,7,12-14,19H,5-6,8-11H2,(H,24,27) KNLFQURAVAITLS-UHFFFAOYSA-N 50252780 CHEMBL494470::N-Cyclopropyl-3-(1-(4-morpholinyl)-6-phthalazinyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252780&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25129831 104105513 CHEMBL494470 ZINC40952652 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434333 C[C@H]1COCCN1c1nncc2cc(ccc12)-c1cc(ccc1C)C(=O)NC1CC1 InChI=1S/C24H26N4O2/c1-15-3-4-18(24(29)26-20-6-7-20)12-22(15)17-5-8-21-19(11-17)13-25-27-23(21)28-9-10-30-14-16(28)2/h3-5,8,11-13,16,20H,6-7,9-10,14H2,1-2H3,(H,26,29)/t16-/m0/s1 OYVCLLCTQUHVCE-INIZCTEOSA-N 50252779 CHEMBL494469::N-Cyclopropyl-4-methyl-3-(1-((3S)-3-methyl-4-morpholinyl)-6-phthalazinyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252779&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11848825 104105512 CHEMBL494469 ZINC36475661 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434334 Cc1ccc(cc1-c1ccc2c(nncc2c1)N1CCOCC1)C(=O)NC1CC1 InChI=1S/C23H24N4O2/c1-15-2-3-17(23(28)25-19-5-6-19)13-21(15)16-4-7-20-18(12-16)14-24-26-22(20)27-8-10-29-11-9-27/h2-4,7,12-14,19H,5-6,8-11H2,1H3,(H,25,28) OZELIFLDRWQKKG-UHFFFAOYSA-N 50252778 CHEMBL494272::N-Cyclopropyl-4-methyl-3-(1-(4-morpholino)-6-phthalazinyl)-benzamide Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252778&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25129830 104105511 CHEMBL494272 ZINC40953558 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50434335 Cc1ccc(cc1-c1ccc2c(NCCN3CCOCC3)nncc2c1)C(=O)NC1CC1 InChI=1S/C25H29N5O2/c1-17-2-3-19(25(31)28-21-5-6-21)15-23(17)18-4-7-22-20(14-18)16-27-29-24(22)26-8-9-30-10-12-32-13-11-30/h2-4,7,14-16,21H,5-6,8-13H2,1H3,(H,26,29)(H,28,31) XNOPUGWJDVUCJD-UHFFFAOYSA-N 50252740 CHEMBL494270::N-Cyclopropyl-4-methyl-3-(1-((2-(4-morpholino)ethyl)amino)-6-phthalazinyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm8005417 10.7270/Q2WH2PTN 18817365 Herberich, B; Cao, GQ; Chakrabarti, PP; Falsey, JR; Pettus, L; Rzasa, RM; Reed, AB; Reichelt, A; Sham, K; Thaman, M; Wurz, RP; Xu, S; Zhang, D; Hsieh, F; Lee, MR; Syed, R; Li, V; Grosfeld, D; Plant, MH; Henkle, B; Sherman, L; Middleton, S; Wong, LM; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252740&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25129829 104105478 CHEMBL494270 ZINC40953247 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50439549 COc1ccc2OCC(Cc2c1)c1nc2cc(cc(F)c2[nH]1)-c1ccnc(N)n1 InChI=1S/C21H18FN5O2/c1-28-14-2-3-18-12(7-14)6-13(10-29-18)20-25-17-9-11(8-15(22)19(17)27-20)16-4-5-24-21(23)26-16/h2-5,7-9,13H,6,10H2,1H3,(H,25,27)(H2,23,24,26) LGNRWEUQQPIDQM-UHFFFAOYSA-N 50246461 4-(7-fluoro-2-(6-methoxy-3,4-dihydro-2H-chromen-3-yl)-3H-benzo[d]imidazol-5-yl)pyrimidin-2-amine::CHEMBL452598 Mitogen-activated protein kinase 10 Homo sapiens 16800 ChEMBL 10.1016/j.bmcl.2008.10.095 10.7270/Q2T43SX6 18996009 Sessions, EH; Yin, Y; Bannister, TD; Weiser, A; Griffin, E; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Schurer, SC; Schroter, T; LoGrasso, P; Feng, Y The Scripps Research Institute-Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246461&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44129168 104101887 CHEMBL452598 ZINC40846345 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50447532 Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) ZEHBZHZMQSHZFI-UHFFFAOYSA-N 50135286 CHEMBL3745885 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.045 10.7270/Q24Q7WT8 26762835 Reddy, MV; Akula, B; Jatiani, S; Vasquez-Del Carpio, R; Billa, VK; Mallireddigari, MR; Cosenza, SC; Venkata Subbaiah, DR; Bharathi, EV; Pallela, VR; Ramkumar, P; Jain, R; Aggarwal, AK; Reddy, EP Icahn School of Medicine at Mount Sinai http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50135286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50135286&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 67240318 336951802 CHEMBL3745885 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50456129 O[C@H]1CC[C@@H](CC1)c1[nH]ncc1-c1ccnc(NC2CCCC2)n1 InChI=1S/C18H25N5O/c24-14-7-5-12(6-8-14)17-15(11-20-23-17)16-9-10-19-18(22-16)21-13-3-1-2-4-13/h9-14,24H,1-8H2,(H,20,23)(H,19,21,22)/t12-,14- JCJAEEODSKNKTC-MQMHXKEQSA-N 50277910 4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyrazol-3-yl)cyclohexanol::CHEMBL507249 Mitogen-activated protein kinase 10 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2009.03.023 10.7270/Q26H4H9D 19327989 Humphries, PS; Lafontaine, JA; Agree, CS; Alexander, D; Chen, P; Do, QQ; Li, LY; Lunney, EA; Rajapakse, RJ; Siegel, K; Timofeevski, SL; Wang, T; Wilhite, DM Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277910&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44591740 104120373 CHEMBL507249 ZINC40379254 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50459433 O[C@H]1CC[C@@H](CC1)Nc1ccc2nnc(-c3cccc(c3)C(F)(F)F)n2n1 InChI=1S/C18H18F3N5O/c19-18(20,21)12-3-1-2-11(10-12)17-24-23-16-9-8-15(25-26(16)17)22-13-4-6-14(27)7-5-13/h1-3,8-10,13-14,27H,4-7H2,(H,22,25)/t13-,14- DJIOCMRPQBSLOC-HDJSIYSDSA-N 50258424 CHEMBL494221::trans-4-(3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-ylamino)cyclohexanol Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2009.04.061 10.7270/Q21J99PJ 19414255 Grey, R; Pierce, AC; Bemis, GW; Jacobs, MD; Moody, CS; Jajoo, R; Mohal, N; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258424&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44219633 104109107 CHEMBL494221 ZINC40953870 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50459434 FC(F)(F)c1cccc(c1)-c1nnc2ccc(NC3CCNCC3)nn12 InChI=1S/C17H17F3N6/c18-17(19,20)12-3-1-2-11(10-12)16-24-23-15-5-4-14(25-26(15)16)22-13-6-8-21-9-7-13/h1-5,10,13,21H,6-9H2,(H,22,25) SENFEQVLOFSJFU-UHFFFAOYSA-N 50258287 CHEMBL493169::N-(piperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-amine Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2009.04.061 10.7270/Q21J99PJ 19414255 Grey, R; Pierce, AC; Bemis, GW; Jacobs, MD; Moody, CS; Jajoo, R; Mohal, N; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258287&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44219632 104109030 CHEMBL493169 ZINC40430676 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516204 Cc1ccc2C(N=O)C(=O)N(Cc3cc(F)cc4COCOc34)c2c1 InChI=1S/C18H15FN2O4/c1-10-2-3-14-15(4-10)21(18(22)16(14)20-23)7-11-5-13(19)6-12-8-24-9-25-17(11)12/h2-6,16H,7-9H2,1H3 CEFHLBGJHWUOBZ-UHFFFAOYSA-N 50297455 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-6-methylindolin-2-one::CHEMBL551140 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297455&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934385 104138986 CHEMBL551140 ZINC43021644 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516205 Fc1cc(CN2C(=O)C(N=O)c3ccc(Br)cc23)c2OCOCc2c1 InChI=1S/C17H12BrFN2O4/c18-11-1-2-13-14(5-11)21(17(22)15(13)20-23)6-9-3-12(19)4-10-7-24-8-25-16(9)10/h1-5,15H,6-8H2 GMANSIMHEQVNLM-UHFFFAOYSA-N 50297456 6-bromo-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one::CHEMBL549453 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297456&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934386 104138987 CHEMBL549453 ZINC03994183 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516206 Fc1cc(CN2C(=O)C(N=O)c3c2cccc3C=C)c2OCOCc2c1 InChI=1S/C19H15FN2O4/c1-2-11-4-3-5-15-16(11)17(21-24)19(23)22(15)8-12-6-14(20)7-13-9-25-10-26-18(12)13/h2-7,17H,1,8-10H2 LVJQKGYIYJKDPU-UHFFFAOYSA-N 50297457 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-vinylindolin-2-one::CHEMBL564389 Mitogen-activated protein kinase 10 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297457&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934387 104138988 CHEMBL564389 ZINC03994188 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516207 COC(=O)c1ccc2C(N=O)C(=O)N(Cc3cc(F)cc4COCOc34)c2c1 InChI=1S/C19H15FN2O6/c1-26-19(24)10-2-3-14-15(6-10)22(18(23)16(14)21-25)7-11-4-13(20)5-12-8-27-9-28-17(11)12/h2-6,16H,7-9H2,1H3 UEZLNCMGFPWFJJ-UHFFFAOYSA-N 50297458 (Z)-methyl 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-2-oxoindoline-6-carboxylate::CHEMBL564428 Mitogen-activated protein kinase 10 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297458&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934388 104138989 CHEMBL564428 ZINC43059484 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516208 Fc1cc(CN2C(=O)C(N=O)c3c2cccc3Br)c2OCOCc2c1 InChI=1S/C17H12BrFN2O4/c18-12-2-1-3-13-14(12)15(20-23)17(22)21(13)6-9-4-11(19)5-10-7-24-8-25-16(9)10/h1-5,15H,6-8H2 XQWJRSINCQFUSK-UHFFFAOYSA-N 50297459 4-bromo-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one::CHEMBL563057 Mitogen-activated protein kinase 10 Homo sapiens 185 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297459&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934389 104138990 CHEMBL563057 ZINC43016226 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516209 Fc1cc(CN2C(=O)C(N=O)c3ccc(cc23)-c2ccccc2)c2OCOCc2c1 InChI=1S/C23H17FN2O4/c24-18-8-16(22-17(9-18)12-29-13-30-22)11-26-20-10-15(14-4-2-1-3-5-14)6-7-19(20)21(25-28)23(26)27/h1-10,21H,11-13H2 XXIJBUACZUHBLC-UHFFFAOYSA-N 50297460 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-6-phenylindolin-2-one::CHEMBL549653 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297460&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934390 104138991 CHEMBL549653 ZINC43015101 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516211 COc1ccc2C(N=O)C(=O)N(Cc3cc(F)cc4COCOc34)c2c1 InChI=1S/C18H15FN2O5/c1-24-13-2-3-14-15(6-13)21(18(22)16(14)20-23)7-10-4-12(19)5-11-8-25-9-26-17(10)11/h2-6,16H,7-9H2,1H3 ISDSSVKCDNZSHN-UHFFFAOYSA-N 50297462 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-6-methoxyindolin-2-one::CHEMBL560541 Mitogen-activated protein kinase 10 Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297462&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934392 104138993 CHEMBL560541 ZINC43071191 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516212 OC(=O)c1ccc2C(N=O)C(=O)N(Cc3cc(F)cc4COCOc34)c2c1 InChI=1S/C18H13FN2O6/c19-12-3-10(16-11(4-12)7-26-8-27-16)6-21-14-5-9(18(23)24)1-2-13(14)15(20-25)17(21)22/h1-5,15H,6-8H2,(H,23,24) FUUZLFFKNWEXKB-UHFFFAOYSA-N 50297463 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-2-oxoindoline-6-carboxylic acid::CHEMBL556925 Mitogen-activated protein kinase 10 Homo sapiens 300 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297463&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934393 104138994 CHEMBL556925 ZINC43018834 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50514061 Cn1c2n(ncc2c(Nc2cc(ccc2Cl)C(=O)NC2CC2)cc1=O)-c1ccc(F)cc1 InChI=1S/C23H19ClFN5O2/c1-29-21(31)11-19(17-12-26-30(23(17)29)16-7-3-14(25)4-8-16)28-20-10-13(2-9-18(20)24)22(32)27-15-5-6-15/h2-4,7-12,15,28H,5-6H2,1H3,(H,27,32) VPYHMFOFGLWNPN-UHFFFAOYSA-N 50296636 4-chloro-N-cyclopropyl-3-(1-(4-fluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-ylamino)benzamide::CHEMBL561932 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.06.058 10.7270/Q27S7NT0 19574047 Wurz, RP; Pettus, LH; Xu, S; Henkle, B; Sherman, L; Plant, M; Miner, K; McBride, H; Wong, LM; Saris, CJ; Lee, MR; Chmait, S; Mohr, C; Hsieh, F; Tasker, AS Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50296636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50296636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44517743 104138167 CHEMBL561932 ZINC43121661 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516213 Fc1cc(CN2C(=O)C(N=O)c3ccc(cc23)C(F)(F)F)c2OCOCc2c1 InChI=1S/C18H12F4N2O4/c19-12-3-9(16-10(4-12)7-27-8-28-16)6-24-14-5-11(18(20,21)22)1-2-13(14)15(23-26)17(24)25/h1-5,15H,6-8H2 MHGQNYSIUVGSEG-UHFFFAOYSA-N 50297464 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-6-(trifluoromethyl)indolin-2-one::CHEMBL556721 Mitogen-activated protein kinase 10 Homo sapiens 330 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297464&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934394 104138995 CHEMBL556721 ZINC42989756 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516214 Nc1ccc2C(N=O)C(=O)N(Cc3cc(F)cc4COCOc34)c2c1 InChI=1S/C17H14FN3O4/c18-11-3-9(16-10(4-11)7-24-8-25-16)6-21-14-5-12(19)1-2-13(14)15(20-23)17(21)22/h1-5,15H,6-8,19H2 IOVLUJNTPAPLMR-UHFFFAOYSA-N 50297465 6-amino-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one::CHEMBL562009 Mitogen-activated protein kinase 10 Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297465&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934395 104138996 CHEMBL562009 ZINC43076984 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516215 Fc1ccc2N(Cc3cc(F)cc4COCOc34)C(=O)C(N=O)c2c1 InChI=1S/C17H12F2N2O4/c18-11-1-2-14-13(5-11)15(20-23)17(22)21(14)6-9-3-12(19)4-10-7-24-8-25-16(9)10/h1-5,15H,6-8H2 IMZIMTGGFNPNNN-UHFFFAOYSA-N 50297466 (3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime::(Z)-5-fluoro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one::CHEMBL561685 Mitogen-activated protein kinase 10 Homo sapiens 440 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297466&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934396 104138997 CHEMBL561685 ZINC39261135 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516217 CS(=O)(=O)Nc1ccc2C(N=O)C(=O)N(Cc3cc(F)cc4COCOc34)c2c1 InChI=1S/C18H16FN3O6S/c1-29(25,26)21-13-2-3-14-15(6-13)22(18(23)16(14)20-24)7-10-4-12(19)5-11-8-27-9-28-17(10)11/h2-6,16,21H,7-9H2,1H3 GJZNNAGHMOUCRN-UHFFFAOYSA-N 50297467 CHEMBL564616::N-(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-2-oxoindolin-6-yl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 460 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297467&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934397 104138998 CHEMBL564616 ZINC43076203 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516218 Fc1cc(CN2C(=O)C(N=O)c3ccccc23)c2OCOCc2c1 InChI=1S/C17H13FN2O4/c18-12-5-10(16-11(6-12)8-23-9-24-16)7-20-14-4-2-1-3-13(14)15(19-22)17(20)21/h1-6,15H,7-9H2 KNCGNJQWPKBRPB-UHFFFAOYSA-N 50297468 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one::CHEMBL552487 Mitogen-activated protein kinase 10 Homo sapiens 510 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297468&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934398 104138999 CHEMBL552487 ZINC43024859 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516219 CCC(=O)Nc1ccc2C(N=O)C(=O)N(Cc3cc(F)cc4COCOc34)c2c1 InChI=1S/C20H18FN3O5/c1-2-17(25)22-14-3-4-15-16(7-14)24(20(26)18(15)23-27)8-11-5-13(21)6-12-9-28-10-29-19(11)12/h3-7,18H,2,8-10H2,1H3,(H,22,25) CYMSMBQNHAQGPJ-UHFFFAOYSA-N 50297469 CHEMBL552423::N-(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-2-oxoindolin-6-yl)propionamide Mitogen-activated protein kinase 10 Homo sapiens 610 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297469&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934399 104139000 CHEMBL552423 ZINC43120383 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516220 [O-][N+](=O)c1ccc2C(N=O)C(=O)N(Cc3cc(F)cc4COCOc34)c2c1 InChI=1S/C17H12FN3O6/c18-11-3-9(16-10(4-11)7-26-8-27-16)6-20-14-5-12(21(24)25)1-2-13(14)15(19-23)17(20)22/h1-5,15H,6-8H2 LRCGKAXJVDYBAO-UHFFFAOYSA-N 50297470 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-6-nitroindolin-2-one::CHEMBL551341 Mitogen-activated protein kinase 10 Homo sapiens 640 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297470&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934400 104139001 CHEMBL551341 ZINC43063829 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516221 Cc1cccc2N(Cc3cc(F)cc4COCOc34)C(=O)C(N=O)c12 InChI=1S/C18H15FN2O4/c1-10-3-2-4-14-15(10)16(20-23)18(22)21(14)7-11-5-13(19)6-12-8-24-9-25-17(11)12/h2-6,16H,7-9H2,1H3 JMGJSDSWOOEFNG-UHFFFAOYSA-N 50297471 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-methylindolin-2-one::CHEMBL557012 Mitogen-activated protein kinase 10 Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297471&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934401 104139002 CHEMBL557012 ZINC42989224 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516222 Fc1cc(CN2C(=O)C(N=O)c3cc(Cl)ccc23)c2OCOCc2c1 InChI=1S/C17H12ClFN2O4/c18-11-1-2-14-13(5-11)15(20-23)17(22)21(14)6-9-3-12(19)4-10-7-24-8-25-16(9)10/h1-5,15H,6-8H2 ZCLHYILVMNBSNR-UHFFFAOYSA-N 50297472 5-chloro-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one::CHEMBL560344 Mitogen-activated protein kinase 10 Homo sapiens 740 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297472&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934402 104139003 CHEMBL560344 ZINC43072291 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516223 Fc1cc(CN2C(=O)C(N=O)c3c2cccc3C=Cc2ccccc2)c2OCOCc2c1 InChI=1S/C25H19FN2O4/c26-20-11-18(24-19(12-20)14-31-15-32-24)13-28-21-8-4-7-17(22(21)23(27-30)25(28)29)10-9-16-5-2-1-3-6-16/h1-12,23H,13-15H2 IYSRUXGBJFBFHF-UHFFFAOYSA-N 50297461 (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime::1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-styrylindolin-2-one::CHEMBL561540 Mitogen-activated protein kinase 10 Homo sapiens 740 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297461&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search J67 3G9L 91934391 104138992 CHEMBL561540 ZINC39261472 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516224 COc1cc(CN2C(=O)C(N=O)c3cc(F)ccc23)cc(OC)c1 InChI=1S/C17H15FN2O4/c1-23-12-5-10(6-13(8-12)24-2)9-20-15-4-3-11(18)7-14(15)16(19-22)17(20)21/h3-8,16H,9H2,1-2H3 ZRJFHGFUWBUZAW-UHFFFAOYSA-N 50297473 1-(3,5-dimethoxybenzyl)-5-fluoro-3-(hydroxyimino)indolin-2-one::CHEMBL550939 Mitogen-activated protein kinase 10 Homo sapiens 790 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297473&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934403 104139004 CHEMBL550939 ZINC42990140 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516225 [O-][N+](=O)c1cccc(CN2C(=O)C(N=O)c3ccccc23)c1 InChI=1S/C15H11N3O4/c19-15-14(16-20)12-6-1-2-7-13(12)17(15)9-10-4-3-5-11(8-10)18(21)22/h1-8,14H,9H2 LUHBWADISOXFCE-UHFFFAOYSA-N 50297474 3-(hydroxyimino)-1-(3-nitrobenzyl)indolin-2-one::CHEMBL564999 Mitogen-activated protein kinase 10 Homo sapiens 940 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297474&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934404 104139005 CHEMBL564999 ZINC03994182 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516226 COc1cc(CN2C(=O)C(N=O)c3ccccc23)cc(OC)c1 InChI=1S/C17H16N2O4/c1-22-12-7-11(8-13(9-12)23-2)10-19-15-6-4-3-5-14(15)16(18-21)17(19)20/h3-9,16H,10H2,1-2H3 NXABZZPVCHWXIM-UHFFFAOYSA-N 50297475 1-(3,5-dimethoxybenzyl)-3-(hydroxyimino)indolin-2-one::CHEMBL550534 Mitogen-activated protein kinase 10 Homo sapiens 990 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297475&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934405 104139006 CHEMBL550534 ZINC43014232 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516227 CCNC(=O)c1ccc2C(N=O)C(=O)N(Cc3cc(F)cc4COCOc34)c2c1 InChI=1S/C20H18FN3O5/c1-2-22-19(25)11-3-4-15-16(7-11)24(20(26)17(15)23-27)8-12-5-14(21)6-13-9-28-10-29-18(12)13/h3-7,17H,2,8-10H2,1H3,(H,22,25) PPENAOABXJETGA-UHFFFAOYSA-N 50297476 CHEMBL562919::N-ethyl-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-2-oxoindoline-6-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297476&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934406 104139007 CHEMBL562919 ZINC42989758 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516228 CCc1cccc2N(Cc3cc(F)cc4COCOc34)C(=O)C(N=O)c12 InChI=1S/C19H17FN2O4/c1-2-11-4-3-5-15-16(11)17(21-24)19(23)22(15)8-12-6-14(20)7-13-9-25-10-26-18(12)13/h3-7,17H,2,8-10H2,1H3 YNAKNLXNQMTXCI-UHFFFAOYSA-N 50297477 4-ethyl-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)indolin-2-one::CHEMBL554060 Mitogen-activated protein kinase 10 Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297477&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934407 104139008 CHEMBL554060 ZINC43015786 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516229 COc1ccc(CN2C(=O)C(N=O)c3cc(F)ccc23)cc1 InChI=1S/C16H13FN2O3/c1-22-12-5-2-10(3-6-12)9-19-14-7-4-11(17)8-13(14)15(18-21)16(19)20/h2-8,15H,9H2,1H3 NRGHJPXGJNCGQR-UHFFFAOYSA-N 50297478 5-fluoro-3-(hydroxyimino)-1-(4-methoxybenzyl)indolin-2-one::CHEMBL564745 Mitogen-activated protein kinase 10 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297478&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934408 104139009 CHEMBL564745 ZINC43058898 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516230 Fc1cc(CN2C(=O)C(N=O)c3cc(OC(F)(F)F)ccc23)c2OCOCc2c1 InChI=1S/C18H12F4N2O5/c19-11-3-9(16-10(4-11)7-27-8-28-16)6-24-14-2-1-12(29-18(20,21)22)5-13(14)15(23-26)17(24)25/h1-5,15H,6-8H2 MZKUNDAMPNORKF-UHFFFAOYSA-N 50297479 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-5-(trifluoromethoxy)indolin-2-one::CHEMBL552018 Mitogen-activated protein kinase 10 Homo sapiens 1700 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297479&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934409 104139010 CHEMBL552018 ZINC43062200 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516231 Fc1cc(CN2C(=O)C(N=O)c3c2cccc3-c2ccccc2)c2OCOCc2c1 InChI=1S/C23H17FN2O4/c24-17-9-15(22-16(10-17)12-29-13-30-22)11-26-19-8-4-7-18(14-5-2-1-3-6-14)20(19)21(25-28)23(26)27/h1-10,21H,11-13H2 IFXYOMXNXTVROS-UHFFFAOYSA-N 50297480 (3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime::1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-phenylindolin-2-one::CHEMBL549385 Mitogen-activated protein kinase 10 Homo sapiens 1800 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297480&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search J88 3G9N 91934410 104139011 CHEMBL549385 ZINC39262491 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516232 Fc1cc(CN2C(=O)C(N=O)c3c2cccc3C#N)c2OCOCc2c1 InChI=1S/C18H12FN3O4/c19-13-4-11(17-12(5-13)8-25-9-26-17)7-22-14-3-1-2-10(6-20)15(14)16(21-24)18(22)23/h1-5,16H,7-9H2 OVCPFCXDWPXDSJ-UHFFFAOYSA-N 50297481 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-2-oxoindoline-4-carbonitrile::CHEMBL554276 Mitogen-activated protein kinase 10 Homo sapiens 2000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297481&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934411 104139012 CHEMBL554276 ZINC43015707 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516233 Brc1ccc2N(Cc3ccccc3)C(=O)C(N=O)c2c1 InChI=1S/C15H11BrN2O2/c16-11-6-7-13-12(8-11)14(17-20)15(19)18(13)9-10-4-2-1-3-5-10/h1-8,14H,9H2 OUJRLOZAKDFUPB-UHFFFAOYSA-N 50297482 1-benzyl-5-bromo-3-(hydroxyimino)indolin-2-one::CHEMBL552488 Mitogen-activated protein kinase 10 Homo sapiens 2500 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297482&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934412 104139013 CHEMBL552488 ZINC43058886 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516234 Cc1ccc2N(Cc3cccc(c3)C(F)(F)F)C(=O)C(N=O)c2c1 InChI=1S/C17H13F3N2O2/c1-10-5-6-14-13(7-10)15(21-24)16(23)22(14)9-11-3-2-4-12(8-11)17(18,19)20/h2-8,15H,9H2,1H3 MTHLUZKAMVJIRU-UHFFFAOYSA-N 50297483 3-(hydroxyimino)-5-methyl-1-(3-(trifluoromethyl)benzyl)indolin-2-one::CHEMBL559351 Mitogen-activated protein kinase 10 Homo sapiens 2700 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297483&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934413 104139014 CHEMBL559351 ZINC05750925 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516237 Clc1cccc(CN2C(=O)C(N=O)c3ccccc23)c1 InChI=1S/C15H11ClN2O2/c16-11-5-3-4-10(8-11)9-18-13-7-2-1-6-12(13)14(17-20)15(18)19/h1-8,14H,9H2 YVYPILMPFGQRRP-UHFFFAOYSA-N 50297485 1-(3-chlorobenzyl)-3-(hydroxyimino)indolin-2-one::CHEMBL561403 Mitogen-activated protein kinase 10 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297485&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934415 104139016 CHEMBL561403 ZINC08773073 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516238 FC(F)(F)c1cccc(CN2C(=O)C(N=O)c3ccccc23)c1 InChI=1S/C16H11F3N2O2/c17-16(18,19)11-5-3-4-10(8-11)9-21-13-7-2-1-6-12(13)14(20-23)15(21)22/h1-8,14H,9H2 FWZLCGHGGHGKHW-UHFFFAOYSA-N 50297486 3-(hydroxyimino)-1-(3-(trifluoromethyl)benzyl)indolin-2-one::CHEMBL559325 Mitogen-activated protein kinase 10 Homo sapiens 5200 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297486&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934416 104139017 CHEMBL559325 ZINC13597513 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516239 Fc1cccc(c1)-c1cccc2N(Cc3cc(F)cc4COCOc34)C(=O)C(N=O)c12 InChI=1S/C23H16F2N2O4/c24-16-4-1-3-13(7-16)18-5-2-6-19-20(18)21(26-29)23(28)27(19)10-14-8-17(25)9-15-11-30-12-31-22(14)15/h1-9,21H,10-12H2 BDEXBHZFFRSETC-UHFFFAOYSA-N 50297487 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-4-(3-fluorophenyl)-3-(hydroxyimino)indolin-2-one::CHEMBL557003 Mitogen-activated protein kinase 10 Homo sapiens 5800 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297487&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934417 104139018 CHEMBL557003 ZINC42964876 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516240 Clc1ccc(CN2C(=O)C(N=O)c3ccccc23)cc1 InChI=1S/C15H11ClN2O2/c16-11-7-5-10(6-8-11)9-18-13-4-2-1-3-12(13)14(17-20)15(18)19/h1-8,14H,9H2 VKIFMWQLDVJWOH-UHFFFAOYSA-N 50297488 1-(4-chlorobenzyl)-3-(hydroxyimino)indolin-2-one::CHEMBL570540 Mitogen-activated protein kinase 10 Homo sapiens 6700 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297488&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934418 104139019 CHEMBL570540 ZINC08577574 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516241 Cc1cccc(CN2C(=O)C(N=O)c3ccccc23)c1 InChI=1S/C16H14N2O2/c1-11-5-4-6-12(9-11)10-18-14-8-3-2-7-13(14)15(17-20)16(18)19/h2-9,15H,10H2,1H3 UNKPTFFOMJTTFC-UHFFFAOYSA-N 50297489 3-(hydroxyimino)-1-(3-methylbenzyl)indolin-2-one::CHEMBL557971 Mitogen-activated protein kinase 10 Homo sapiens 6800 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297489&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934419 104139020 CHEMBL557971 ZINC42920212 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516242 [O-][N+](=O)c1ccc(CN2C(=O)C(N=O)c3ccccc23)cc1 InChI=1S/C15H11N3O4/c19-15-14(16-20)12-3-1-2-4-13(12)17(15)9-10-5-7-11(8-6-10)18(21)22/h1-8,14H,9H2 FJNWINYBGRYDPD-UHFFFAOYSA-N 50297490 3-(hydroxyimino)-1-(4-nitrobenzyl)indolin-2-one::CHEMBL559949 Mitogen-activated protein kinase 10 Homo sapiens 7000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297490&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934420 104139021 CHEMBL559949 ZINC43080252 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516245 Fc1cccc(CN2C(=O)C(N=O)c3ccccc23)c1 InChI=1S/C15H11FN2O2/c16-11-5-3-4-10(8-11)9-18-13-7-2-1-6-12(13)14(17-20)15(18)19/h1-8,14H,9H2 UPSQMRRGBZLGCK-UHFFFAOYSA-N 50297491 1-(3-fluorobenzyl)-3-(hydroxyimino)indolin-2-one::CHEMBL564611 Mitogen-activated protein kinase 10 Homo sapiens 8100 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297491&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934421 104139022 CHEMBL564611 ZINC42922855 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516246 Fc1ccc(CN2C(=O)C(N=O)c3ccccc23)cc1 InChI=1S/C15H11FN2O2/c16-11-7-5-10(6-8-11)9-18-13-4-2-1-3-12(13)14(17-20)15(18)19/h1-8,14H,9H2 ACXIRRBFELVQAJ-UHFFFAOYSA-N 50297492 1-(4-fluorobenzyl)-3-(hydroxyimino)indolin-2-one::CHEMBL552079 Mitogen-activated protein kinase 10 Homo sapiens 8300 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297492&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934422 104139023 CHEMBL552079 ZINC43064108 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516247 Fc1ccccc1CN1C(=O)C(N=O)c2ccccc12 InChI=1S/C15H11FN2O2/c16-12-7-3-1-5-10(12)9-18-13-8-4-2-6-11(13)14(17-20)15(18)19/h1-8,14H,9H2 GCOCMHSFISHQBV-UHFFFAOYSA-N 50297493 1-(2-fluorobenzyl)-3-(hydroxyimino)indolin-2-one::CHEMBL562974 Mitogen-activated protein kinase 10 Homo sapiens 8500 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297493&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934423 104139024 CHEMBL562974 ZINC42923176 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516249 Cc1ccc(CN2C(=O)C(N=O)c3ccccc23)cc1 InChI=1S/C16H14N2O2/c1-11-6-8-12(9-7-11)10-18-14-5-3-2-4-13(14)15(17-20)16(18)19/h2-9,15H,10H2,1H3 VEKWHUILUUJNCV-UHFFFAOYSA-N 50297494 3-(hydroxyimino)-1-(4-methylbenzyl)indolin-2-one::CHEMBL540228 Mitogen-activated protein kinase 10 Homo sapiens 9900 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297494&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934424 104139025 CHEMBL540228 ZINC13597510 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516251 Clc1ccc2N(Cc3ccccc3)C(=O)C(N=O)c2c1 InChI=1S/C15H11ClN2O2/c16-11-6-7-13-12(8-11)14(17-20)15(19)18(13)9-10-4-2-1-3-5-10/h1-8,14H,9H2 JKQQMQPTGHUCLE-UHFFFAOYSA-N 50297495 1-benzyl-5-chloro-3-(hydroxyimino)indolin-2-one::CHEMBL572133 Mitogen-activated protein kinase 10 Homo sapiens 12000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297495&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934425 104139026 CHEMBL572133 ZINC43058884 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516252 Fc1ccc(cc1)-c1cccc2N(Cc3cc(F)cc4COCOc34)C(=O)C(N=O)c12 InChI=1S/C23H16F2N2O4/c24-16-6-4-13(5-7-16)18-2-1-3-19-20(18)21(26-29)23(28)27(19)10-14-8-17(25)9-15-11-30-12-31-22(14)15/h1-9,21H,10-12H2 JWFUUZCLAVKLGU-UHFFFAOYSA-N 50297484 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-4-(4-fluorophenyl)-3-(hydroxyimino)indolin-2-one::CHEMBL564447 Mitogen-activated protein kinase 10 Homo sapiens 13000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297484&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934414 104139015 CHEMBL564447 ZINC43079471 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516256 COC(=O)c1cccc2N(Cc3cc(F)cc4COCOc34)C(=O)C(N=O)c12 InChI=1S/C19H15FN2O6/c1-26-19(24)13-3-2-4-14-15(13)16(21-25)18(23)22(14)7-10-5-12(20)6-11-8-27-9-28-17(10)11/h2-6,16H,7-9H2,1H3 ONRPIAXQYQNTRG-UHFFFAOYSA-N 50297496 CHEMBL559687::methyl 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-2-oxoindoline-4-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 30000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297496&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934426 104139027 CHEMBL559687 ZINC43079475 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516267 O=NC1C(=O)N(Cc2ccccc2)c2ccccc12 InChI=1S/C15H12N2O2/c18-15-14(16-19)12-8-4-5-9-13(12)17(15)10-11-6-2-1-3-7-11/h1-9,14H,10H2 LSFWOZLLANVISW-UHFFFAOYSA-N 50297497 1-benzyl-3-(hydroxyimino)indolin-2-one::CHEMBL569605 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297497&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57070545 104139028 CHEMBL569605 ZINC17992131 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516268 [O-][N+](=O)c1ccccc1CN1C(=O)C(N=O)c2ccccc12 InChI=1S/C15H11N3O4/c19-15-14(16-20)11-6-2-4-8-13(11)17(15)9-10-5-1-3-7-12(10)18(21)22/h1-8,14H,9H2 NTDLGXSRFIRIMO-UHFFFAOYSA-N 50297498 3-(hydroxyimino)-1-(2-nitrobenzyl)indolin-2-one::CHEMBL563545 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297498&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934427 104139029 CHEMBL563545 ZINC43011145 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516269 Cc1ccc2N(Cc3ccccc3)C(=O)C(N=O)c2c1 InChI=1S/C16H14N2O2/c1-11-7-8-14-13(9-11)15(17-20)16(19)18(14)10-12-5-3-2-4-6-12/h2-9,15H,10H2,1H3 UIYBZTCLOBJQAN-UHFFFAOYSA-N 50297499 1-benzyl-3-(hydroxyimino)-5-methylindolin-2-one::CHEMBL560145 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297499&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934428 104139030 CHEMBL560145 ZINC04744625 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516270 Fc1ccc2N(Cc3ccccc3)C(=O)C(N=O)c2c1 InChI=1S/C15H11FN2O2/c16-11-6-7-13-12(8-11)14(17-20)15(19)18(13)9-10-4-2-1-3-5-10/h1-8,14H,9H2 LPJOVAWBJVPMMZ-UHFFFAOYSA-N 50297500 1-benzyl-5-fluoro-3-(hydroxyimino)indolin-2-one::CHEMBL559254 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297500&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934429 104139031 CHEMBL559254 ZINC43070715 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516271 Cc1ccc2N(Cc3cccc(C)c3)C(=O)C(N=O)c2c1 InChI=1S/C17H16N2O2/c1-11-4-3-5-13(8-11)10-19-15-7-6-12(2)9-14(15)16(18-21)17(19)20/h3-9,16H,10H2,1-2H3 HBLSREQDMGAQDB-UHFFFAOYSA-N 50297501 3-(hydroxyimino)-5-methyl-1-(3-methylbenzyl)indolin-2-one::CHEMBL550938 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297501&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934430 104139032 CHEMBL550938 ZINC43023687 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516273 Fc1cc(CN2C(=O)C(N=O)c3c2cccc3CCc2ccccc2)c2OCOCc2c1 InChI=1S/C25H21FN2O4/c26-20-11-18(24-19(12-20)14-31-15-32-24)13-28-21-8-4-7-17(22(21)23(27-30)25(28)29)10-9-16-5-2-1-3-6-16/h1-8,11-12,23H,9-10,13-15H2 YEKJDXYMLGTMJG-UHFFFAOYSA-N 50297454 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3-(hydroxyimino)-4-phenethylindolin-2-one::CHEMBL559885 Mitogen-activated protein kinase 10 Homo sapiens >15000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297454&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934384 104138985 CHEMBL559885 ZINC43122025 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50516281 Cc1ccc2N(C(=O)C(N=O)c2c1)c1ccccc1 InChI=1S/C15H12N2O2/c1-10-7-8-13-12(9-10)14(16-19)15(18)17(13)11-5-3-2-4-6-11/h2-9,14H,1H3 OMBLLWQMNPAPMK-UHFFFAOYSA-N 50297502 3-(hydroxyimino)-5-methyl-1-phenylindolin-2-one::CHEMBL553689 Mitogen-activated protein kinase 10 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2009.03.043 10.7270/Q2F76CMZ 19361991 Cao, J; Gao, H; Bemis, G; Salituro, F; Ledeboer, M; Harrington, E; Wilke, S; Taslimi, P; Pazhanisamy, S; Xie, X; Jacobs, M; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297502&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91934431 104139033 CHEMBL553689 ZINC42921495 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50536361 CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1 InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3 BOCQIRYQTWRJMD-UHFFFAOYSA-N 50206421 3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole::4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)pyridine::4-[3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl]pyridine::CHEMBL220227 Mitogen-activated protein kinase 10 Homo sapiens 540 ChEMBL 10.1021/jm9005127 10.7270/Q28K7961 19591487 Peifer, C; Abadleh, M; Bischof, J; Hauser, D; Schattel, V; Hirner, H; Knippschild, U; Laufer, S Eberhard-Karls University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50206421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50206421&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16115351 104084501 CHEMBL220227 ZINC35271649 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50543920 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 10 Homo sapiens 290 ChEMBL 10.1021/jm901392x 10.7270/Q2CR5TF8 20078117 Koch, P; Jahns, H; Schattel, V; Goettert, M; Laufer, S Eberhard-Karls-University of T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50543927 CC(C)Nc1cc(ccn1)-c1nc2ccccc2nc1-c1ccc(F)cc1 InChI=1S/C22H19FN4/c1-14(2)25-20-13-16(11-12-24-20)22-21(15-7-9-17(23)10-8-15)26-18-5-3-4-6-19(18)27-22/h3-14H,1-2H3,(H,24,25) JQXHBPGAMYZRJM-UHFFFAOYSA-N 50304016 4-(3-(4-Fluorophenyl)quinoxalin-2-yl)-N-isopropylpyridin-2-amine::CHEMBL565564 Mitogen-activated protein kinase 10 Homo sapiens 3950 ChEMBL 10.1021/jm901392x 10.7270/Q2CR5TF8 20078117 Koch, P; Jahns, H; Schattel, V; Goettert, M; Laufer, S Eberhard-Karls-University of T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304016&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 45488127 104158377 CHEMBL565564 ZINC45245417 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50543937 Fc1ccc(cc1)-c1nc2ccccc2nc1-c1ccncc1 InChI=1S/C19H12FN3/c20-15-7-5-13(6-8-15)18-19(14-9-11-21-12-10-14)23-17-4-2-1-3-16(17)22-18/h1-12H FNBHMLCCTFZWSR-UHFFFAOYSA-N 50304025 2-(4-Fluorophenyl)-3-(pyridin-4-yl)quinoxaline::CHEMBL565381 Mitogen-activated protein kinase 10 Homo sapiens 31800 ChEMBL 10.1021/jm901392x 10.7270/Q2CR5TF8 20078117 Koch, P; Jahns, H; Schattel, V; Goettert, M; Laufer, S Eberhard-Karls-University of T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304025&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 45488146 104158386 CHEMBL565381 ZINC45254128 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566698 Fc1ccc(cc1)-c1ncn(CCCNC(=O)c2ccccc2)c1-c1ccncc1 InChI=1S/C24H21FN4O/c25-21-9-7-18(8-10-21)22-23(19-11-14-26-15-12-19)29(17-28-22)16-4-13-27-24(30)20-5-2-1-3-6-20/h1-3,5-12,14-15,17H,4,13,16H2,(H,27,30) VLMWLALTUHMVKC-UHFFFAOYSA-N 50173171 CHEMBL199247::N-(3-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-1-yl)propyl)benzamide::N-{3-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-imidazol-1-yl]-propyl}-benzamide Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173171&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44404444 104059142 CHEMBL199247 ZINC28528239 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566699 CCCNc1nccc(n1)-c1c(nc2CC[C@@H](CO)n12)-c1ccc(F)cc1 InChI=1S/C20H22FN5O/c1-2-10-22-20-23-11-9-16(24-20)19-18(13-3-5-14(21)6-4-13)25-17-8-7-15(12-27)26(17)19/h3-6,9,11,15,27H,2,7-8,10,12H2,1H3,(H,22,23,24)/t15-/m0/s1 AMLKAXKHAOGCFY-HNNXBMFYSA-N 50173167 (S)-(2-(4-fluorophenyl)-3-(2-(propylamino)pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl)methanol::CHEMBL198756::[(S)-2-(4-Fluoro-phenyl)-3-(2-propylamino-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]-methanol Mitogen-activated protein kinase 10 Homo sapiens 2.5 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50173167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50173167&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16007071 104059138 CHEMBL198756 ZINC13985866 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566701 CCCNc1nccc(n1)-c1c(nc2CC[C@@H](Cc3ccc(OC)cc3)n12)-c1ccc(F)cc1 InChI=1S/C27H28FN5O/c1-3-15-29-27-30-16-14-23(31-27)26-25(19-6-8-20(28)9-7-19)32-24-13-10-21(33(24)26)17-18-4-11-22(34-2)12-5-18/h4-9,11-12,14,16,21H,3,10,13,15,17H2,1-2H3,(H,29,30,31)/t21-/m0/s1 XTEXFYJKENTXMP-NRFANRHFSA-N 50314146 (S)-4-(2-(4-fluorophenyl)-5-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl)-N-propylpyrimidin-2-amine::CHEMBL1094013 Mitogen-activated protein kinase 10 Homo sapiens 10.9 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314146&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46884198 104148507 CHEMBL1094013 ZINC49111441 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566705 CN(C)c1c(cnn1Cc1ccccc1)-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1 InChI=1S/C22H28N6O/c1-27(2)21-19(14-24-28(21)15-16-6-4-3-5-7-16)20-12-13-23-22(26-20)25-17-8-10-18(29)11-9-17/h3-7,12-14,17-18,29H,8-11,15H2,1-2H3,(H,23,25,26)/t17-,18- SZNPQONVZOSPLO-IYARVYRRSA-N 50314147 CHEMBL1094014::trans-4-(4-(1-benzyl-5-(dimethylamino)-1H-pyrazol-4-yl)pyrimidin-2-ylamino)cyclohexanol Mitogen-activated protein kinase 10 Homo sapiens 5 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314147&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46884199 104148508 CHEMBL1094014 ZINC43175302 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566708 O[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-c1cn[nH]c1C1CCCOC1 InChI=1S/C18H25N5O2/c24-14-5-3-13(4-6-14)21-18-19-8-7-16(22-18)15-10-20-23-17(15)12-2-1-9-25-11-12/h7-8,10,12-14,24H,1-6,9,11H2,(H,20,23)(H,19,21,22)/t12?,13-,14- SCIILXOOXBQBFM-KAOCOCSGSA-N 50314148 CHEMBL1089007::trans-4-(4-(3-(tetrahydro-2H-pyran-3-yl)-1H-pyrazol-4-yl)pyrimidin-2-ylamino)cyclohexanol Mitogen-activated protein kinase 10 Homo sapiens 16 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314148&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44138038 104148509 CHEMBL1089007 ZINC49068172 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566709 N(c1ccccc1)c1ccc2c(n[nH]c2c1)-c1ccccc1 InChI=1S/C19H15N3/c1-3-7-14(8-4-1)19-17-12-11-16(13-18(17)21-22-19)20-15-9-5-2-6-10-15/h1-13,20H,(H,21,22) UCZOJYXXXUINID-UHFFFAOYSA-N 50172925 CHEMBL383177::N,3-diphenyl-1H-indazol-6-amine::Phenyl-(3-phenyl-1H-indazol-6-yl)-amine Mitogen-activated protein kinase 10 Homo sapiens 48 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172925&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10236389 104058960 CHEMBL383177 ZINC03816999 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566712 CN(C)CCCC(=O)Nc1cc(cc(c1)-c1n[nH]c2cc(Nc3ccccc3Cl)ccc12)C(O)=O InChI=1S/C26H26ClN5O3/c1-32(2)11-5-8-24(33)29-19-13-16(12-17(14-19)26(34)35)25-20-10-9-18(15-23(20)30-31-25)28-22-7-4-3-6-21(22)27/h3-4,6-7,9-10,12-15,28H,5,8,11H2,1-2H3,(H,29,33)(H,30,31)(H,34,35) QHYSKDAWIUFROA-UHFFFAOYSA-N 50314149 3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-5-(4-(dimethylamino)butanamido)benzoic acid::3-{6-[(2-CHLOROPHENYL)AMINO]-1H-INDAZOL-3-YL}-5-{[4-(DIMETHYLAMINO)BUTANOYL]AMINO}BENZOIC ACID::CHEMBL1092764 Mitogen-activated protein kinase 10 Homo sapiens 3 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314149&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search AIZ 2B1P 9549178 104148510 CHEMBL1092764 ZINC16051799 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566715 O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)C1CCOC1 InChI=1S/C21H20N4O2/c26-21(17-8-11-27-14-17)25-20-13-16(7-10-23-20)15-6-9-22-19(12-15)24-18-4-2-1-3-5-18/h1-7,9-10,12-13,17H,8,11,14H2,(H,22,24)(H,23,25,26) YZIQMIAREGGHFQ-UHFFFAOYSA-N 50178832 CHEMBL203535::N-(2'-(phenylamino)-4,4'-bipyridin-2-yl)tetrahydrofuran-3-carboxamide::N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178832&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10247954 104064105 CHEMBL203535 ZINC28571781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50565654 C(N1CCCCC1)c1onc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccccc1 InChI=1S/C25H31N5O/c1-4-10-19(11-5-1)24-23(22(31-29-24)18-30-16-8-3-9-17-30)21-14-15-26-25(28-21)27-20-12-6-2-7-13-20/h1,4-5,10-11,14-15,20H,2-3,6-9,12-13,16-18H2,(H,26,27,28) KJRYEDFCBDQQSC-UHFFFAOYSA-N 50313646 CHEMBL1080582::N-cyclohexyl-4-(3-phenyl-5-(piperidin-1-ylmethyl)isoxazol-4-yl)pyrimidin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 26 ChEMBL 10.1021/jm901132v 10.7270/Q2VD6ZK0 20166671 Morphy, R Schering-Plough http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313646&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10093433 104148007 CHEMBL1080582 ZINC49033748 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50560739 CN(C)CCCNC(=O)c1ccc2OCC(Cc2c1)c1nc2ccc(cc2s1)-c1cn[nH]c1 InChI=1S/C25H27N5O2S/c1-30(2)9-3-8-26-24(31)17-5-7-22-18(10-17)11-19(15-32-22)25-29-21-6-4-16(12-23(21)33-25)20-13-27-28-14-20/h4-7,10,12-14,19H,3,8-9,11,15H2,1-2H3,(H,26,31)(H,27,28) MUVYYVZAJFICKR-UHFFFAOYSA-N 50311728 3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(3-(dimethylamino)propyl)chroman-6-carboxamide::CHEMBL1079921::SR-6074 Mitogen-activated protein kinase 10 Homo sapiens 5456 ChEMBL 10.1016/j.bmcl.2009.09.115 10.7270/Q2VX0GN0 19837589 Yin, Y; Lin, L; Ruiz, C; Cameron, MD; Pocas, J; Grant, W; Schroter, T; Chen, W; Duckett, D; Schurer, S; Lograsso, P; Feng, Y Translational Research Institute and Department of Molecular Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311728&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 45375859 104146089 CHEMBL1079921 ZINC49032268 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50560740 CCN(Cc1cccc(OC)c1)C(=O)c1nc2ccc(cc2s1)-c1cn[nH]c1 InChI=1S/C21H20N4O2S/c1-3-25(13-14-5-4-6-17(9-14)27-2)21(26)20-24-18-8-7-15(10-19(18)28-20)16-11-22-23-12-16/h4-12H,3,13H2,1-2H3,(H,22,23) QUMAYKINOQNINW-UHFFFAOYSA-N 50311726 CHEMBL1081196::N-ethyl-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)benzo[d]thiazole-2-carboxamide Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2009.09.115 10.7270/Q2VX0GN0 19837589 Yin, Y; Lin, L; Ruiz, C; Cameron, MD; Pocas, J; Grant, W; Schroter, T; Chen, W; Duckett, D; Schurer, S; Lograsso, P; Feng, Y Translational Research Institute and Department of Molecular Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311726&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46879806 104146087 CHEMBL1081196 ZINC49785110 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50560741 COc1cccc(CN(CCN(C)C)C(=O)c2nc3ccc(cc3s2)-c2cn[nH]c2)c1 InChI=1S/C23H25N5O2S/c1-27(2)9-10-28(15-16-5-4-6-19(11-16)30-3)23(29)22-26-20-8-7-17(12-21(20)31-22)18-13-24-25-14-18/h4-8,11-14H,9-10,15H2,1-3H3,(H,24,25) OMVMGDVRMSCTFN-UHFFFAOYSA-N 50311713 CHEMBL1080279::N-(2-(dimethylamino)ethyl)-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)benzo[d]thiazole-2-carboxamide::SR-6494 Mitogen-activated protein kinase 10 Homo sapiens 13760 ChEMBL 10.1016/j.bmcl.2009.09.115 10.7270/Q2VX0GN0 19837589 Yin, Y; Lin, L; Ruiz, C; Cameron, MD; Pocas, J; Grant, W; Schroter, T; Chen, W; Duckett, D; Schurer, S; Lograsso, P; Feng, Y Translational Research Institute and Department of Molecular Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50311713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50311713&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44634494 104146074 CHEMBL1080279 ZINC49034075 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566508 Cn1c2nc(NC(CCO)CCO)ncc2cc(Oc2ccc(F)cc2F)c1=O InChI=1S/C19H20F2N4O4/c1-25-17-11(10-22-19(24-17)23-13(4-6-26)5-7-27)8-16(18(25)28)29-15-3-2-12(20)9-14(15)21/h2-3,8-10,13,26-27H,4-7H2,1H3,(H,22,23,24) JYYLVUFNAHSSFE-UHFFFAOYSA-N 50314070 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL1090089::pamapimod Mitogen-activated protein kinase 10 Homo sapiens 19 ChEMBL 10.1021/jm9012906 10.7270/Q27H1JQC 19950901 Goldstein, DM; Kuglstatter, A; Lou, Y; Soth, MJ Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314070&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search FLW 3FLW 16220188 104148431 CHEMBL1090089 ZINC30691792 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566518 NC(=O)N(c1ccc(C(N)=O)c(n1)-c1ccc(F)cc1F)c1c(F)cccc1F InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29) FYSRKRZDBHOFAY-UHFFFAOYSA-N 50314071 2-(2,4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide::CHEMBL1090090::VX-702 Mitogen-activated protein kinase 10 Homo sapiens 780 ChEMBL 10.1021/jm9012906 10.7270/Q27H1JQC 19950901 Goldstein, DM; Kuglstatter, A; Lou, Y; Soth, MJ Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314071&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10341154 104148432 CHEMBL1090090 6059 ZINC36377992 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566692 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566694 Clc1ccc(cc1)C(=O)NCc1ccc(s1)S(=O)(=O)N1CCC(CC1)n1nnc2ccccc12 InChI=1S/C23H22ClN5O3S2/c24-17-7-5-16(6-8-17)23(30)25-15-19-9-10-22(33-19)34(31,32)28-13-11-18(12-14-28)29-21-4-2-1-3-20(21)26-27-29/h1-10,18H,11-15H2,(H,25,30) XLVWDHAXEFKTIB-UHFFFAOYSA-N 50158551 CHEMBL383955::N-((5-(4-(1H-benzo[d][1,2,3]triazol-1-yl)piperidin-1-ylsulfonyl)thiophen-2-yl)methyl)-4-chlorobenzamide::N-5-4-1H-benzo[d][1,2,3]triazol-1-yl)piperidin-1-ylsulfonyl)thiophen-2-yl)methyl)-4-chlorobenzamide Mitogen-activated protein kinase 10 Homo sapiens 150 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50158551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50158551&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9892736 104045242 CHEMBL383955 ZINC01493969 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50566697 N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1 InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) RCYPVQCPYKNSTG-UHFFFAOYSA-N 50169959 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile::AS-601245::AS601245::CHEMBL1788116::CHEMBL191384::[3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1021/jm9003279 10.7270/Q2KS6RP5 20146479 Siddiqui, MA; Reddy, PA Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169959&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JN5 3CY3 10109823 104054707 CHEMBL1788116CHEMBL191384 5997 ZINC13647791 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50595461 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50595877 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50596241 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31,33,41H,17H2,1-3H3,(H,36,40)/t23-,24-,31-,33+,35+/m1/s1 ZZSBPGIGIUFJRA-AKIDMACVSA-N 50326054 CHEMBL1240703 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326054&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52945601 123105169 CHEMBL1240703 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50593168 Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NCCN4CCCC4)n3n2)cc1Cl InChI=1S/C26H26Cl2N6O/c27-21-8-3-18(15-22(21)28)16-30-24-9-10-25-31-17-23(34(25)32-24)19-4-6-20(7-5-19)26(35)29-11-14-33-12-1-2-13-33/h3-10,15,17H,1-2,11-14,16H2,(H,29,35)(H,30,32) HERFSFFCWPWNME-UHFFFAOYSA-N 50325373 4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide::CHEMBL1222474 Mitogen-activated protein kinase 10 Homo sapiens 90000 ChEMBL 10.1016/j.bmcl.2010.07.026 10.7270/Q2513ZDM 20675134 Shimizu, H; Tanaka, S; Toki, T; Yasumatsu, I; Akimoto, T; Morishita, K; Yamasaki, T; Yasukochi, T; Iimura, S Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325373&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 49864785 117646694 CHEMBL1222474 ZINC58575584 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50591585 COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1 InChI=1S/C24H29N5O3/c1-29(2)8-9-32-23-12-16(19-14-26-27-15-19)5-7-21(23)28-24(30)22-11-18-10-20(31-3)6-4-17(18)13-25-22/h4-7,10,12,14-15,22,25H,8-9,11,13H2,1-3H3,(H,26,27)(H,28,30)/t22-/m1/s1 JPIZMTCZKMZLDC-JOCHJYFZSA-N 50324575 (R)-N-(2-(2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)-phenyl)-6-methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxamide::CHEMBL1215171 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm100579r 10.7270/Q2833S8C 20684608 Fang, X; Yin, Y; Chen, YT; Yao, L; Wang, B; Cameron, MD; Lin, L; Khan, S; Ruiz, C; Schroter, T; Grant, W; Weiser, A; Pocas, J; Pachori, A; Schurer, S; Lograsso, P; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324575&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44197572 117645896 CHEMBL1215171 ZINC58568630 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50591586 COc1ccc2CN[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCC1CCN(C)CC1)-c1cn[nH]c1 InChI=1S/C27H33N5O3/c1-32-9-7-18(8-10-32)17-35-26-13-19(22-15-29-30-16-22)4-6-24(26)31-27(33)25-12-21-11-23(34-2)5-3-20(21)14-28-25/h3-6,11,13,15-16,18,25,28H,7-10,12,14,17H2,1-2H3,(H,29,30)(H,31,33)/t25-/m1/s1 GFWDPXHTWJXOEI-RUZDIDTESA-N 50324574 (R)-6-Methoxy-N-(2-((1-methylpiperidin-4-yl)methoxy)-4-(1Hpyrazol-4-yl)phenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::CHEMBL1215304 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm100579r 10.7270/Q2833S8C 20684608 Fang, X; Yin, Y; Chen, YT; Yao, L; Wang, B; Cameron, MD; Lin, L; Khan, S; Ruiz, C; Schroter, T; Grant, W; Weiser, A; Pocas, J; Pachori, A; Schurer, S; Lograsso, P; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324574&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46864283 117645895 CHEMBL1215304 ZINC58574949 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50591587 CN(C)CCOc1cc(-c2cn[nH]c2)c(F)cc1NC(=O)[C@H]1Cc2ccccc2CN1 InChI=1S/C23H26FN5O2/c1-29(2)7-8-31-22-10-18(17-13-26-27-14-17)19(24)11-20(22)28-23(30)21-9-15-5-3-4-6-16(15)12-25-21/h3-6,10-11,13-14,21,25H,7-9,12H2,1-2H3,(H,26,27)(H,28,30)/t21-/m1/s1 BKCNFBWOOAHROL-OAQYLSRUSA-N 50324578 (R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-pyrazol-4-yl)phenyl)-1,2,3,4-tetrahydroiso-quinoline-3-carboxamide::CHEMBL1215524 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm100579r 10.7270/Q2833S8C 20684608 Fang, X; Yin, Y; Chen, YT; Yao, L; Wang, B; Cameron, MD; Lin, L; Khan, S; Ruiz, C; Schroter, T; Grant, W; Weiser, A; Pocas, J; Pachori, A; Schurer, S; Lograsso, P; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324578&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44198874 117645899 CHEMBL1215524 ZINC58591055 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50591588 CCN1Cc2ccccc2C[C@@H]1C(=O)Nc1cc(F)c(cc1OCCN(C)C)-c1cn[nH]c1 InChI=1S/C25H30FN5O2/c1-4-31-16-18-8-6-5-7-17(18)11-23(31)25(32)29-22-13-21(26)20(19-14-27-28-15-19)12-24(22)33-10-9-30(2)3/h5-8,12-15,23H,4,9-11,16H2,1-3H3,(H,27,28)(H,29,32)/t23-/m1/s1 ZNDQOACBIHODQO-HSZRJFAPSA-N 50324592 (R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-pyrazol-4-yl)phenyl)-2-ethyl-1,2,3,4-tetra-hydroisoquinoline-3-carboxamide::CHEMBL1215526 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1021/jm100579r 10.7270/Q2833S8C 20684608 Fang, X; Yin, Y; Chen, YT; Yao, L; Wang, B; Cameron, MD; Lin, L; Khan, S; Ruiz, C; Schroter, T; Grant, W; Weiser, A; Pocas, J; Pachori, A; Schurer, S; Lograsso, P; Feng, Y The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50324592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50324592&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46901260 117645913 CHEMBL1215526 ZINC58568675 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50593169 Clc1ccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)cc1Cl InChI=1S/C25H24Cl2N6O/c26-20-8-3-16(12-21(20)27)13-29-23-9-10-24-30-15-22(33(24)32-23)17-4-6-18(7-5-17)25(34)31-14-19-2-1-11-28-19/h3-10,12,15,19,28H,1-2,11,13-14H2,(H,29,32)(H,31,34)/t19-/m0/s1 LRTVAHMMILMPNA-IBGZPJMESA-N 50325374 (S)-4-(6-(3,4-dichlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide::CHEMBL1222565 Mitogen-activated protein kinase 10 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2010.07.026 10.7270/Q2513ZDM 20675134 Shimizu, H; Tanaka, S; Toki, T; Yasumatsu, I; Akimoto, T; Morishita, K; Yamasaki, T; Yasukochi, T; Iimura, S Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325374&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 49864850 117646695 CHEMBL1222565 ZINC58592015 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50593170 O=C(NC[C@@H]1CCCN1)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12 InChI=1S/C22H26N6O/c29-22(26-13-18-2-1-11-23-18)17-7-5-16(6-8-17)19-14-25-21-10-9-20(27-28(19)21)24-12-15-3-4-15/h5-10,14-15,18,23H,1-4,11-13H2,(H,24,27)(H,26,29)/t18-/m0/s1 VDTACYBUGLTWCI-SFHVURJKSA-N 50325375 (S)-4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide::CHEMBL1222990 Mitogen-activated protein kinase 10 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2010.07.026 10.7270/Q2513ZDM 20675134 Shimizu, H; Tanaka, S; Toki, T; Yasumatsu, I; Akimoto, T; Morishita, K; Yamasaki, T; Yasukochi, T; Iimura, S Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325375&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46933384 117646696 CHEMBL1222990 ZINC58581321 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50593171 Clc1cccc(CNc2ccc3ncc(-c4ccc(cc4)C(=O)NC[C@@H]4CCCN4)n3n2)c1 InChI=1S/C25H25ClN6O/c26-20-4-1-3-17(13-20)14-28-23-10-11-24-29-16-22(32(24)31-23)18-6-8-19(9-7-18)25(33)30-15-21-5-2-12-27-21/h1,3-4,6-11,13,16,21,27H,2,5,12,14-15H2,(H,28,31)(H,30,33)/t21-/m0/s1 ZDRUVHBRKQJQIU-NRFANRHFSA-N 50325368 (S)-4-(6-(3-chlorobenzylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(pyrrolidin-2-ylmethyl)benzamide::CHEMBL1222992 Mitogen-activated protein kinase 10 Homo sapiens 78000 ChEMBL 10.1016/j.bmcl.2010.07.026 10.7270/Q2513ZDM 20675134 Shimizu, H; Tanaka, S; Toki, T; Yasumatsu, I; Akimoto, T; Morishita, K; Yamasaki, T; Yasukochi, T; Iimura, S Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325368&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 49865153 117646689 CHEMBL1222992 ZINC58591271 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50593172 CN(C)CCNC(=O)c1ccc(cc1)-c1cnc2ccc(NCC3CC3)nn12 InChI=1S/C21H26N6O/c1-26(2)12-11-22-21(28)17-7-5-16(6-8-17)18-14-24-20-10-9-19(25-27(18)20)23-13-15-3-4-15/h5-10,14-15H,3-4,11-13H2,1-2H3,(H,22,28)(H,23,25) DVIFVYZZPLRXHC-UHFFFAOYSA-N 50325369 4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridazin-3-yl)-N-(2-(dimethylamino)ethyl)benzamide::CHEMBL1223203 Mitogen-activated protein kinase 10 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2010.07.026 10.7270/Q2513ZDM 20675134 Shimizu, H; Tanaka, S; Toki, T; Yasumatsu, I; Akimoto, T; Morishita, K; Yamasaki, T; Yasukochi, T; Iimura, S Daiichi Sankyo Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50325369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50325369&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24959046 117646690 CHEMBL1223203 ZINC58581467 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50596445 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50596683 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50592095 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 10 Homo sapiens 62 ChEMBL 10.1016/j.bmcl.2010.06.157 10.7270/Q2WQ040K 20655210 Kuglstatter, A; Ghate, M; Tsing, S; Villasenor, AG; Shaw, D; Barnett, JW; Browner, MF Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611560 CCOC(=O)c1sccc1NC(=O)Cc1ccccc1 InChI=1S/C15H15NO3S/c1-2-19-15(18)14-12(8-9-20-14)16-13(17)10-11-6-4-3-5-7-11/h3-9H,2,10H2,1H3,(H,16,17) RJDMNHJOMJVPHJ-UHFFFAOYSA-N 50332053 CHEMBL1288966::ethyl 3-(2-phenylacetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332053&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52941011 123111168 CHEMBL1288966 ZINC64573767 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611561 CC(C)OC(=O)c1sccc1NC(=O)Cc1ccccc1 InChI=1S/C16H17NO3S/c1-11(2)20-16(19)15-13(8-9-21-15)17-14(18)10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,17,18) IKURLBUMVCRMBN-UHFFFAOYSA-N 50332054 CHEMBL1288243::isopropyl 3-(2-phenylacetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332054&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52946152 123111169 CHEMBL1288243 ZINC64573009 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611562 NC(=O)c1sccc1NC(=O)Cc1ccccc1 InChI=1S/C13H12N2O2S/c14-13(17)12-10(6-7-18-12)15-11(16)8-9-4-2-1-3-5-9/h1-7H,8H2,(H2,14,17)(H,15,16) INZMHUJPOZBGRG-UHFFFAOYSA-N 50332055 3-(2-phenylacetamido)thiophene-2-carboxamide::CHEMBL1288993 Mitogen-activated protein kinase 10 Homo sapiens 4400 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332055&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52943431 123111170 CHEMBL1288993 ZINC64549751 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611563 COCCNC(=O)c1sccc1NC(=O)Cc1ccccc1 InChI=1S/C16H18N2O3S/c1-21-9-8-17-16(20)15-13(7-10-22-15)18-14(19)11-12-5-3-2-4-6-12/h2-7,10H,8-9,11H2,1H3,(H,17,20)(H,18,19) MSKPVRYQLLTJOD-UHFFFAOYSA-N 50332056 CHEMBL1288244::N-(2-methoxyethyl)-3-(2-phenylacetamido)thiophene-2-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 3800 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332056&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52947386 123111171 CHEMBL1288244 ZINC64573387 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611564 COCCN(C)C(=O)c1sccc1NC(=O)Cc1ccccc1 InChI=1S/C17H20N2O3S/c1-19(9-10-22-2)17(21)16-14(8-11-23-16)18-15(20)12-13-6-4-3-5-7-13/h3-8,11H,9-10,12H2,1-2H3,(H,18,20) XHDHYCWIABWXSU-UHFFFAOYSA-N 50332092 CHEMBL1288245::N-(2-methoxyethyl)-N-methyl-3-(2-phenylacetamido)thiophene-2-carboxamide Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332092&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52948602 123111207 CHEMBL1288245 ZINC64560730 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611565 COC(=O)c1nnsc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C16H13N3O3S/c1-22-16(21)14-15(23-19-18-14)17-13(20)9-11-7-4-6-10-5-2-3-8-12(10)11/h2-8H,9H2,1H3,(H,17,20) HIDKGTZCIARNAE-UHFFFAOYSA-N 50332057 CHEMBL1288271::methyl 5-(2-(naphthalen-1-yl)acetamido)-1,2,3-thiadiazole-4-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332057&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52947399 123111172 CHEMBL1288271 ZINC64548854 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611566 COC(=O)c1nonc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C16H13N3O4/c1-22-16(21)14-15(19-23-18-14)17-13(20)9-11-7-4-6-10-5-2-3-8-12(10)11/h2-8H,9H2,1H3,(H,17,19,20) YBTBQESAUIACKA-UHFFFAOYSA-N 50332058 CHEMBL1288272::methyl 4-(2-(naphthalen-1-yl)acetamido)-1,2,5-oxadiazole-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332058&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52942532 123111173 CHEMBL1288272 ZINC64540026 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611567 CCOC(=O)c1c(C)nsc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C19H18N2O3S/c1-3-24-19(23)17-12(2)21-25-18(17)20-16(22)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10H,3,11H2,1-2H3,(H,20,22) NNEIYGAXNREVRG-UHFFFAOYSA-N 50332059 CHEMBL1288273::ethyl 3-methyl-5-(2-(naphthalen-1-yl)acetamido)isothiazole-4-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332059&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52946172 123111174 CHEMBL1288273 ZINC64573044 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611568 COC(=O)c1scnc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C17H14N2O3S/c1-22-17(21)15-16(18-10-23-15)19-14(20)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,10H,9H2,1H3,(H,19,20) GFVLBTJETWUORV-UHFFFAOYSA-N 50332060 CHEMBL1288297::methyl 4-(2-(naphthalen-1-yl)acetamido)thiazole-5-carboxylate Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332060&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52947421 123111175 CHEMBL1288297 ZINC64560450 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611569 COC(=O)c1cccnc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C19H16N2O3/c1-24-19(23)16-10-5-11-20-18(16)21-17(22)12-14-8-4-7-13-6-2-3-9-15(13)14/h2-11H,12H2,1H3,(H,20,21,22) AXEYMKDXMBOZEO-UHFFFAOYSA-N 50332061 CHEMBL1288298::methyl 2-(2-(naphthalen-1-yl)acetamido)nicotinate Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332061&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52947422 123111176 CHEMBL1288298 ZINC64560468 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611570 Cc1ccncc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C18H16N2O/c1-13-9-10-19-12-17(13)20-18(21)11-15-7-4-6-14-5-2-3-8-16(14)15/h2-10,12H,11H2,1H3,(H,20,21) HBFMJQQWIKOCML-UHFFFAOYSA-N 50332062 CHEMBL1288299::N-(4-methylpyridin-3-yl)-2-(naphthalen-1-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332062&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52944962 123111177 CHEMBL1288299 ZINC64560700 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611571 Cc1nccnc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C17H15N3O/c1-12-17(19-10-9-18-12)20-16(21)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,19,20,21) IDTKOQHMJHXWTP-UHFFFAOYSA-N 50332093 CHEMBL1287857::N-(3-methylpyrazin-2-yl)-2-(naphthalen-1-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332093&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52949737 123111208 CHEMBL1287857 ZINC64559218 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611572 COC(=O)c1ccccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C20H17NO3/c1-24-20(23)17-11-4-5-12-18(17)21-19(22)13-15-9-6-8-14-7-2-3-10-16(14)15/h2-12H,13H2,1H3,(H,21,22) GOPWYMQLDSLIRK-UHFFFAOYSA-N 50332063 CHEMBL1287858::methyl 2-(2-(naphthalen-1-yl)acetamido)benzoate Mitogen-activated protein kinase 10 Homo sapiens 1700 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332063&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2231029 123111178 CHEMBL1287858 ZINC02878998 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611573 COC(=O)c1cscc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C18H15NO3S/c1-22-18(21)15-10-23-11-16(15)19-17(20)9-13-7-4-6-12-5-2-3-8-14(12)13/h2-8,10-11H,9H2,1H3,(H,19,20) TYOBDVZTZRJMQI-UHFFFAOYSA-N 50332064 CHEMBL1287859::methyl 4-(2-(naphthalen-1-yl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 900 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332064&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52943626 123111179 CHEMBL1287859 ZINC64560665 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611574 COC(=O)c1[nH]ncc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C17H15N3O3/c1-23-17(22)16-14(10-18-20-16)19-15(21)9-12-7-4-6-11-5-2-3-8-13(11)12/h2-8,10H,9H2,1H3,(H,18,20)(H,19,21) YDBPIRPSGIJXSJ-UHFFFAOYSA-N 50332065 CHEMBL1287886::methyl 4-(2-(naphthalen-1-yl)acetamido)-1H-pyrazole-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 5400 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332065&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52941226 123111180 CHEMBL1287886 ZINC64559017 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611575 COC(=O)c1cnccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C19H16N2O3/c1-24-19(23)16-12-20-10-9-17(16)21-18(22)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10,12H,11H2,1H3,(H,20,21,22) SXKHEFOJRJSMLY-UHFFFAOYSA-N 50332066 CHEMBL1287887::methyl 4-(2-(naphthalen-1-yl)acetamido)nicotinate Mitogen-activated protein kinase 10 Homo sapiens 6500 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332066&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52942436 123111181 CHEMBL1287887 ZINC64573460 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611576 O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1nnco1 InChI=1S/C18H13N3O2S/c22-16(10-13-6-3-5-12-4-1-2-7-14(12)13)20-15-8-9-24-17(15)18-21-19-11-23-18/h1-9,11H,10H2,(H,20,22) ROLXVDFEIIZXAF-UHFFFAOYSA-N 50332067 CHEMBL1287888::N-(2-(1,3,4-oxadiazol-2-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 60 Mitogen-activated protein kinase 10 Homo sapiens 5300 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332067&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869071 123111182 CHEMBL1287888 ZINC64559180 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611577 O=C(Cc1cccc2ccccc12)Nc1ccsc1-n1ccnc1 InChI=1S/C19H15N3OS/c23-18(12-15-6-3-5-14-4-1-2-7-16(14)15)21-17-8-11-24-19(17)22-10-9-20-13-22/h1-11,13H,12H2,(H,21,23) YAMORCRLQFAZCJ-UHFFFAOYSA-N 50332068 CHEMBL1287914::N-(2-(1H-imidazol-1-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 84 Mitogen-activated protein kinase 10 Homo sapiens 9000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332068&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52946059 123111183 CHEMBL1287914 ZINC64559565 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611578 O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1cc[nH]n1 InChI=1S/C19H15N3OS/c23-18(12-14-6-3-5-13-4-1-2-7-15(13)14)21-16-9-11-24-19(16)17-8-10-20-22-17/h1-11H,12H2,(H,20,22)(H,21,23) RAIUWRMGPSZDJL-UHFFFAOYSA-N 50332069 CHEMBL1287915::N-(2-(1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 72 Mitogen-activated protein kinase 10 Homo sapiens 3600 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332069&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869075 123111184 CHEMBL1287915 ZINC64559414 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611579 O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1nnc[nH]1 InChI=1S/C18H14N4OS/c23-16(10-13-6-3-5-12-4-1-2-7-14(12)13)21-15-8-9-24-17(15)18-19-11-20-22-18/h1-9,11H,10H2,(H,21,23)(H,19,20,22) FKBQPAXZYUEULP-UHFFFAOYSA-N 50332070 CHEMBL1287916::N-(2-(1H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 920 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332070&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52948519 123111185 CHEMBL1287916 ZINC64559415 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611580 Cc1nnc(o1)-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C19H15N3O2S/c1-12-21-22-19(24-12)18-16(9-10-25-18)20-17(23)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,20,23) BKDRDDSAZLVHON-UHFFFAOYSA-N 50332071 CHEMBL1287944::N-(2-(5-methyl-1,3,4-oxadiazol-2-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 63 Mitogen-activated protein kinase 10 Homo sapiens 2100 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332071&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52944873 123111186 CHEMBL1287944 ZINC64549834 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611581 Cn1ccc(n1)-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C20H17N3OS/c1-23-11-9-18(22-23)20-17(10-12-25-20)21-19(24)13-15-7-4-6-14-5-2-3-8-16(14)15/h2-12H,13H2,1H3,(H,21,24) UNKZYKXHTPRCOC-UHFFFAOYSA-N 50332072 CHEMBL1287945::N-(2-(1-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 73 Mitogen-activated protein kinase 10 Homo sapiens 42500 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332072&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869147 123111187 CHEMBL1287945 ZINC64549835 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611582 Cc1nnc([nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C19H16N4OS/c1-12-20-19(23-22-12)18-16(9-10-25-18)21-17(24)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,21,24)(H,20,22,23) JIZAXYFIPHHWDF-UHFFFAOYSA-N 50332073 CHEMBL1287974::N-(2-(5-methyl-1H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 550 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332073&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869611 123111188 CHEMBL1287974 ZINC64548868 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611583 Cc1nc(-c2sccc2NC(=O)Cc2cccc3ccccc23)n(C)n1 InChI=1S/C20H18N4OS/c1-13-21-20(24(2)23-13)19-17(10-11-26-19)22-18(25)12-15-8-5-7-14-6-3-4-9-16(14)15/h3-11H,12H2,1-2H3,(H,22,25) GMDHUVZYMRKGIE-UHFFFAOYSA-N 50332074 CHEMBL1287975::N-(2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 3 Mitogen-activated protein kinase 10 Homo sapiens 31500 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332074&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869609 123111189 CHEMBL1287975 ZINC64235697 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611584 Cc1cc(n[nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C20H17N3OS/c1-13-11-18(23-22-13)20-17(9-10-25-20)21-19(24)12-15-7-4-6-14-5-2-3-8-16(14)15/h2-11H,12H2,1H3,(H,21,24)(H,22,23) WECVVDLKMBWACI-UHFFFAOYSA-N 50332075 CHEMBL1288004::N-(2-(5-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 74 Mitogen-activated protein kinase 10 Homo sapiens 9400 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332075&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869223 123111190 CHEMBL1288004 ZINC64559152 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611585 COc1ccc(CC(=O)Nc2ccsc2-n2cncn2)cc1 InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)8-14(20)18-13-6-7-22-15(13)19-10-16-9-17-19/h2-7,9-10H,8H2,1H3,(H,18,20) BEVYWBNCINQJQH-UHFFFAOYSA-N 50332076 CHEMBL1288005::N-(2-(1H-1,2,4-triazol-1-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 6 Mitogen-activated protein kinase 10 Homo sapiens 45600 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332076&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869671 123111191 CHEMBL1288005 ZINC64559153 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611586 COc1ccc(CC(=O)Nc2ccsc2-n2nccn2)cc1 InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)10-14(20)18-13-6-9-22-15(13)19-16-7-8-17-19/h2-9H,10H2,1H3,(H,18,20) KHIAZVHADWMRSJ-UHFFFAOYSA-N 50332077 CHEMBL1288006::N-(2-(2H-1,2,3-triazol-2-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 8 Mitogen-activated protein kinase 10 Homo sapiens 1500 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332077&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869677 123111192 CHEMBL1288006 ZINC64560442 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611587 COc1ccc(CC(=O)Nc2ccsc2N2CCOC2=O)cc1 InChI=1S/C16H16N2O4S/c1-21-12-4-2-11(3-5-12)10-14(19)17-13-6-9-23-15(13)18-7-8-22-16(18)20/h2-6,9H,7-8,10H2,1H3,(H,17,19) JXSJAJUZRYNVGF-UHFFFAOYSA-N 50332078 2-(4-methoxyphenyl)-N-(2-(2-oxooxazolidin-3-yl)thiophen-3-yl)acetamide::CHEMBL1288037::US9796706, Compound 88 Mitogen-activated protein kinase 10 Homo sapiens 37000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332078&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52942482 123111193 CHEMBL1288037 ZINC64559381 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611589 COC(=O)c1sccc1NC(=O)Cc1cccs1 InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14) CXOCENPNQSXLGZ-UHFFFAOYSA-N 50332040 CHEMBL1288895::methyl 3-(2-(thiophen-2-yl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332040&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search SYY 3OXI 2808202 123111155 CHEMBL1288895 ZINC00082427 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611590 COC(=O)c1sccc1NC(=O)Cc1ccccc1 InChI=1S/C14H13NO3S/c1-18-14(17)13-11(7-8-19-13)15-12(16)9-10-5-3-2-4-6-10/h2-8H,9H2,1H3,(H,15,16) YJXMVZWBSKFEBU-UHFFFAOYSA-N 50332041 CHEMBL1288930::methyl 3-(2-phenylacetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 2700 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332041&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 4079571 123111156 CHEMBL1288930 ZINC06126201 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611591 COC(=O)c1sccc1NC(=O)Cc1ccncc1 InChI=1S/C13H12N2O3S/c1-18-13(17)12-10(4-7-19-12)15-11(16)8-9-2-5-14-6-3-9/h2-7H,8H2,1H3,(H,15,16) UDSAZFJLDCDUQO-UHFFFAOYSA-N 50332042 CHEMBL1288931::methyl 3-(2-(pyridin-4-yl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 17200 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332042&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 43623574 123111157 CHEMBL1288931 ZINC36816706 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611592 COC(=O)c1sccc1NC(=O)Cc1ccc(OC)cc1 InChI=1S/C15H15NO4S/c1-19-11-5-3-10(4-6-11)9-13(17)16-12-7-8-21-14(12)15(18)20-2/h3-8H,9H2,1-2H3,(H,16,17) KMRBJGTWVOAUNX-UHFFFAOYSA-N 50332043 CHEMBL1288156::methyl 3-(2-(4-methoxyphenyl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332043&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 897877 123111158 CHEMBL1288156 ZINC00475678 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611593 COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)-c1ccncc1 InChI=1S/C19H16N2O3S/c1-24-19(23)18-16(8-11-25-18)21-17(22)12-13-2-4-14(5-3-13)15-6-9-20-10-7-15/h2-11H,12H2,1H3,(H,21,22) WHORUVUQHFFPNW-UHFFFAOYSA-N 50332044 CHEMBL1288157::methyl 3-(2-(4-(pyridin-4-yl)phenyl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 690 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332044&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52950113 123111159 CHEMBL1288157 ZINC64560841 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611594 COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)-n1ccnc1 InChI=1S/C17H15N3O3S/c1-23-17(22)16-14(6-9-24-16)19-15(21)10-12-2-4-13(5-3-12)20-8-7-18-11-20/h2-9,11H,10H2,1H3,(H,19,21) NVJSHBLBHMSEFL-UHFFFAOYSA-N 50332045 CHEMBL1288158::methyl 3-(2-(4-(1H-imidazol-1-yl)phenyl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332045&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52944914 123111160 CHEMBL1288158 ZINC64560842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611595 COC(=O)c1sccc1NC(=O)Cc1ccc(cc1)C(F)(F)F InChI=1S/C15H12F3NO3S/c1-22-14(21)13-11(6-7-23-13)19-12(20)8-9-2-4-10(5-3-9)15(16,17)18/h2-7H,8H2,1H3,(H,19,20) ABOQVROUVXWAOH-UHFFFAOYSA-N 50332046 CHEMBL1288186::methyl 3-(2-(4-(trifluoromethyl)phenyl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 6900 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332046&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24535122 123111161 CHEMBL1288186 ZINC16470547 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611596 COC(=O)c1sccc1NC(=O)Cc1ccc2ccccc2c1 InChI=1S/C18H15NO3S/c1-22-18(21)17-15(8-9-23-17)19-16(20)11-12-6-7-13-4-2-3-5-14(13)10-12/h2-10H,11H2,1H3,(H,19,20) CDKKUYMXRKJKHI-UHFFFAOYSA-N 50332047 CHEMBL1288187::methyl 3-(2-(naphthalen-2-yl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 3900 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332047&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 26704995 123111162 CHEMBL1288187 ZINC15606685 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611597 COC(=O)c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C18H15NO3S/c1-22-18(21)17-15(9-10-23-17)19-16(20)11-13-7-4-6-12-5-2-3-8-14(12)13/h2-10H,11H2,1H3,(H,19,20) DYRVYVWQRUSNMF-UHFFFAOYSA-N 50332048 CHEMBL1288188::methyl 3-(2-(naphthalen-1-yl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 1500 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332048&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25660569 123111163 CHEMBL1288188 ZINC13000352 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611598 COC(=O)c1sccc1NC(=O)Cc1ccccc1-c1c[nH]nn1 InChI=1S/C16H14N4O3S/c1-23-16(22)15-12(6-7-24-15)18-14(21)8-10-4-2-3-5-11(10)13-9-17-20-19-13/h2-7,9H,8H2,1H3,(H,18,21)(H,17,19,20) TZLRZKYNFSRYDZ-UHFFFAOYSA-N 50332049 CHEMBL1288214::methyl 3-(2-(2-(1H-1,2,3-triazol-4-yl)phenyl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 12600 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332049&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52946145 123111164 CHEMBL1288214 ZINC64560796 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611599 COC(=O)c1sccc1NC(=O)Cc1cccc2cnccc12 InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(6-8-23-16)19-15(20)9-11-3-2-4-12-10-18-7-5-13(11)12/h2-8,10H,9H2,1H3,(H,19,20) JDCPDRSOEKCKGX-UHFFFAOYSA-N 50332050 CHEMBL1288215::methyl 3-(2-(isoquinolin-5-yl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 610 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332050&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52949817 123111165 CHEMBL1288215 ZINC64560798 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611600 COC(=O)c1sccc1NC(=O)Cc1cccc2ncccc12 InChI=1S/C17H14N2O3S/c1-22-17(21)16-14(7-9-23-16)19-15(20)10-11-4-2-6-13-12(11)5-3-8-18-13/h2-9H,10H2,1H3,(H,19,20) MWQGXLPPKAMINM-UHFFFAOYSA-N 50332051 CHEMBL1288216::methyl 3-(2-(quinolin-5-yl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 610 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332051&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52949818 123111166 CHEMBL1288216 ZINC64560570 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611601 CC(=O)c1sccc1NC(=O)Cc1ccccc1 InChI=1S/C14H13NO2S/c1-10(16)14-12(7-8-18-14)15-13(17)9-11-5-3-2-4-6-11/h2-8H,9H2,1H3,(H,15,17) GRNZWZUKBPDEBP-UHFFFAOYSA-N 50332052 CHEMBL1288932::N-(2-acetylthiophen-3-yl)-2-phenylacetamide Mitogen-activated protein kinase 10 Homo sapiens 17000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332052&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52941649 123111167 CHEMBL1288932 ZINC64573002 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611602 OCc1sccc1NC(=O)Cc1ccccc1 InChI=1S/C13H13NO2S/c15-9-12-11(6-7-17-12)14-13(16)8-10-4-2-1-3-5-10/h1-7,15H,8-9H2,(H,14,16) RBTSJYWVZUKXCH-UHFFFAOYSA-N 50332094 CHEMBL1288933::N-(2-(hydroxymethyl)thiophen-3-yl)-2-phenylacetamide Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332094&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52943427 123111209 CHEMBL1288933 ZINC64560834 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611603 CC(N=O)c1sccc1NC(=O)Cc1ccccc1 InChI=1S/C14H14N2O2S/c1-10(16-18)14-12(7-8-19-14)15-13(17)9-11-5-3-2-4-6-11/h2-8,10H,9H2,1H3,(H,15,17) HNIYKNSPGCWWTK-UHFFFAOYSA-N 50332095 CHEMBL1288964::N-(2-(1-(hydroxyimino)ethyl)thiophen-3-yl)-2-phenylacetamide Mitogen-activated protein kinase 10 Homo sapiens 29000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332095&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91933610 123111210 CHEMBL1288964 ZINC64560590 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611604 CC(=C)c1sccc1NC(=O)Cc1ccccc1 InChI=1S/C15H15NOS/c1-11(2)15-13(8-9-18-15)16-14(17)10-12-6-4-3-5-7-12/h3-9H,1,10H2,2H3,(H,16,17) HAYQEKZBDCILER-UHFFFAOYSA-N 50332096 2-phenyl-N-(2-(prop-1-en-2-yl)thiophen-3-yl)acetamide::CHEMBL1288965 Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332096&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52942227 123111211 CHEMBL1288965 ZINC64573162 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611605 COc1ccc(CC(=O)Nc2ccsc2-c2nnc([nH]2)C(F)(F)F)cc1 InChI=1S/C16H13F3N4O2S/c1-25-10-4-2-9(3-5-10)8-12(24)20-11-6-7-26-13(11)14-21-15(23-22-14)16(17,18)19/h2-7H,8H2,1H3,(H,20,24)(H,21,22,23) WKKHWEMTBODBGE-UHFFFAOYSA-N 50332079 2-(4-methoxyphenyl)-N-(2-(5-(trifluoromethyl)-1H-1,2,4-triazol-3-yl)thiophen-3-yl)acetamide::CHEMBL1288038 Mitogen-activated protein kinase 10 Homo sapiens 5900 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332079&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869740 123111194 CHEMBL1288038 ZINC64560815 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611606 COc1ccc(CC(=O)Nc2ccsc2-c2nnc(N)[nH]2)cc1 InChI=1S/C15H15N5O2S/c1-22-10-4-2-9(3-5-10)8-12(21)17-11-6-7-23-13(11)14-18-15(16)20-19-14/h2-7H,8H2,1H3,(H,17,21)(H3,16,18,19,20) AFCVEHHRQVGWID-UHFFFAOYSA-N 50332080 CHEMBL1288039::N-(2-(5-amino-1H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332080&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869742 123111195 CHEMBL1288039 ZINC64559382 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611607 COc1ccc(CC(=O)Nc2ccsc2-c2cn(C)cn2)cc1 InChI=1S/C17H17N3O2S/c1-20-10-15(18-11-20)17-14(7-8-23-17)19-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10-11H,9H2,1-2H3,(H,19,21) RYGONSQYUUISGP-UHFFFAOYSA-N 50332081 2-(4-methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide::CHEMBL1288067::US9796706, Compound 79 Mitogen-activated protein kinase 10 Homo sapiens 31000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332081&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52948565 123111196 CHEMBL1288067 ZINC64559317 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611608 COc1ccc(CC(=O)Nc2ccsc2-c2ncco2)cc1 InChI=1S/C16H14N2O3S/c1-20-12-4-2-11(3-5-12)10-14(19)18-13-6-9-22-15(13)16-17-7-8-21-16/h2-9H,10H2,1H3,(H,18,19) KSZHRLGDJPCAID-UHFFFAOYSA-N 50332082 2-(4-methoxyphenyl)-N-(2-(oxazol-2-yl)thiophen-3-yl)acetamide::CHEMBL1288068::US9796706, Compound 57 Mitogen-activated protein kinase 10 Homo sapiens 800 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332082&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869000 123111197 CHEMBL1288068 ZINC64559318 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611609 COc1ccc(CC(=O)Nc2ccsc2-c2c[nH]c(C)n2)cc1 InChI=1S/C17H17N3O2S/c1-11-18-10-15(19-11)17-14(7-8-23-17)20-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10H,9H2,1-2H3,(H,18,19)(H,20,21) LFLTYJDEZSLZGL-UHFFFAOYSA-N 50332083 2-(4-methoxyphenyl)-N-(2-(2-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide::CHEMBL1288069::US9796706, Compound 82 Mitogen-activated protein kinase 10 Homo sapiens 27000 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332083&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52946092 123111198 CHEMBL1288069 ZINC64573429 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626252 Brc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1 InChI=1S/C17H12BrN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23) GLVDZCDUMFNCFY-UHFFFAOYSA-N 50338262 CHEMBL1682016::N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 33 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338262&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869878 125088364 CHEMBL1682016 ZINC66077421 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626253 Clc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nnc[nH]1 InChI=1S/C17H12ClN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23) MYLVKAPPYVXQKQ-UHFFFAOYSA-N 50338263 CHEMBL1682017::N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338263&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 45102739 125088365 CHEMBL1682017 ZINC66077423 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626254 O=C(Cc1cccc2cnccc12)Nc1scc(C#N)c1-c1nnc[nH]1 InChI=1S/C18H12N6OS/c19-7-13-9-26-18(16(13)17-21-10-22-24-17)23-15(25)6-11-2-1-3-12-8-20-5-4-14(11)12/h1-5,8-10H,6H2,(H,23,25)(H,21,22,24) VINQLWACVZJJIO-UHFFFAOYSA-N 50338264 CHEMBL1682018::N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338264&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868853 125088366 CHEMBL1682018 ZINC66077425 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626255 Brc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1 InChI=1S/C17H12BrN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23) IHBXLESUKAAQDQ-UHFFFAOYSA-N 50338265 CHEMBL1682019::N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338265&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869879 125088367 CHEMBL1682019 ZINC66078016 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626256 Clc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1 InChI=1S/C17H12ClN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23) BUCXDWXDBZUFMV-UHFFFAOYSA-N 50338266 CHEMBL1682020::N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338266&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869816 125088368 CHEMBL1682020 ZINC66078018 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626257 O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1nnc[nH]1 InChI=1S/C18H12N6OS/c19-8-12-9-26-18(16(12)17-21-10-22-24-17)23-15(25)7-11-3-1-5-14-13(11)4-2-6-20-14/h1-6,9-10H,7H2,(H,23,25)(H,21,22,24) XCGZBGKVXSQTFT-UHFFFAOYSA-N 50338267 CHEMBL1682021::N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 39 Mitogen-activated protein kinase 10 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338267&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868856 125088369 CHEMBL1682021 ZINC66078020 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611610 COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21) RVEHZFOKUTZKBA-UHFFFAOYSA-N 50332084 2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-yl)acetamide::CHEMBL1288098::US9796706, Compound 85 Mitogen-activated protein kinase 10 Homo sapiens 1500 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332084&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52941286 123111199 CHEMBL1288098 ZINC64560182 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611611 O=C(Cc1cccc2ncccc12)Nc1ccsc1-c1nnc[nH]1 InChI=1S/C17H13N5OS/c23-15(9-11-3-1-5-13-12(11)4-2-7-18-13)21-14-6-8-24-16(14)17-19-10-20-22-17/h1-8,10H,9H2,(H,21,23)(H,19,20,22) MGGUVSLBKUKUGR-UHFFFAOYSA-N 50332085 CHEMBL1288099::N-(2-(4H-1,2,4-triazol-3-yl)thiophen-3-yl)-2-(quinolin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 560 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332085&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869877 123111200 CHEMBL1288099 ZINC64560184 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611612 O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1cscn1 InChI=1S/C18H13N3OS2/c22-17(8-12-2-1-3-13-9-19-6-4-14(12)13)21-15-5-7-24-18(15)16-10-23-11-20-16/h1-7,9-11H,8H2,(H,21,22) FFPJBQIHDBPVHZ-UHFFFAOYSA-N 50332086 2-(isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide::CHEMBL1288100::US9796706, Compound 48 Mitogen-activated protein kinase 10 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332086&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868930 123111201 CHEMBL1288100 ZINC64560850 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611613 COC(=O)c1ncsc1NC(=O)Cc1cccc2cnccc12 InChI=1S/C16H13N3O3S/c1-22-16(21)14-15(23-9-18-14)19-13(20)7-10-3-2-4-11-8-17-6-5-12(10)11/h2-6,8-9H,7H2,1H3,(H,19,20) ZMICCBVROLVEBZ-UHFFFAOYSA-N 50332087 CHEMBL1288127::methyl 5-(2-(isoquinolin-5-yl)acetamido)thiazole-4-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332087&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52944909 123111202 CHEMBL1288127 ZINC64560464 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611614 O=C(Cc1cccc2cnccc12)Nc1scnc1-c1nnc[nH]1 InChI=1S/C16H12N6OS/c23-13(6-10-2-1-3-11-7-17-5-4-12(10)11)21-16-14(19-9-24-16)15-18-8-20-22-15/h1-5,7-9H,6H2,(H,21,23)(H,18,20,22) CCEORUFGHAKXQE-UHFFFAOYSA-N 50332088 CHEMBL1288128::N-(4-(1H-1,2,4-triazol-3-yl)thiazol-5-yl)-2-(isoquinolin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 820 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332088&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869149 123111203 CHEMBL1288128 ZINC64560477 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611615 Cn1ncnc1-c1ncsc1NC(=O)Cc1cccc2cnccc12 InChI=1S/C17H14N6OS/c1-23-16(19-9-21-23)15-17(25-10-20-15)22-14(24)7-11-3-2-4-12-8-18-6-5-13(11)12/h2-6,8-10H,7H2,1H3,(H,22,24) UIDLYPCNTOHNOP-UHFFFAOYSA-N 50332089 2-(isoquinolin-5-yl)-N-(4-(1-methyl-1H-1,2,4-triazol-5-yl)thiazol-5-yl)acetamide::CHEMBL1288129::US9796706, Compound 68 Mitogen-activated protein kinase 10 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332089&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52942507 123111204 CHEMBL1288129 ZINC64560478 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611616 O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24) ALHGQWSWTWVNNB-UHFFFAOYSA-N 50332090 2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-yl)acetamide::CHEMBL1288159::US9796706, Compound 86 Mitogen-activated protein kinase 10 Homo sapiens 470 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332090&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52948593 123111205 CHEMBL1288159 ZINC64560844 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50611617 O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1 InChI=1S/C17H12N4OS2/c22-15(6-11-2-1-3-12-7-18-5-4-13(11)12)21-17-16(20-10-24-17)14-8-23-9-19-14/h1-5,7-10H,6H2,(H,21,22) BGGSTZPBQKGLOJ-UHFFFAOYSA-N 50332091 CHEMBL1288160::N-(4,4'-bithiazol-5-yl)-2-(isoquinolin-5-yl)acetamide::US9796706, Compound 87 Mitogen-activated protein kinase 10 Homo sapiens 77 ChEMBL 10.1016/j.bmcl.2010.10.066 10.7270/Q20865JW 21071223 Hom, RK; Bowers, S; Sealy, JM; Truong, AP; Probst, GD; Neitzel, ML; Neitz, RJ; Fang, L; Brogley, L; Wu, J; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Quinn, K; Sauer, JM; Powell, K; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332091&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 49839481 123111206 CHEMBL1288160 ZINC64573024 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626358 COC(=O)c1sccc1NC(=O)Cc1cccs1 InChI=1S/C12H11NO3S2/c1-16-12(15)11-9(4-6-18-11)13-10(14)7-8-3-2-5-17-8/h2-6H,7H2,1H3,(H,13,14) CXOCENPNQSXLGZ-UHFFFAOYSA-N 50332040 CHEMBL1288895::methyl 3-(2-(thiophen-2-yl)acetamido)thiophene-2-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332040&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search SYY 3OXI 2808202 123111155 CHEMBL1288895 ZINC00082427 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626359 COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OC)cc1 InChI=1S/C16H17NO4S/c1-10-9-22-15(14(10)16(19)21-3)17-13(18)8-11-4-6-12(20-2)7-5-11/h4-7,9H,8H2,1-3H3,(H,17,18) ZFGJERKBORCEBU-UHFFFAOYSA-N 50338268 CHEMBL1681992::methyl 2-(2-(4-methoxyphenyl)acetamido)-4-methylthiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338268&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53325555 125088370 CHEMBL1681992 ZINC66073771 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626360 CCc1csc(NC(=O)Cc2ccc(OC)cc2)c1C(=O)OC InChI=1S/C17H19NO4S/c1-4-12-10-23-16(15(12)17(20)22-3)18-14(19)9-11-5-7-13(21-2)8-6-11/h5-8,10H,4,9H2,1-3H3,(H,18,19) NUPODSCCIUNZSP-UHFFFAOYSA-N 50338269 CHEMBL1681993::methyl 4-ethyl-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 9110 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338269&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53322569 125088371 CHEMBL1681993 ZINC66073772 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626361 CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C1CC1 InChI=1S/C19H21NO4S/c1-3-24-19(22)17-15(13-6-7-13)11-25-18(17)20-16(21)10-12-4-8-14(23-2)9-5-12/h4-5,8-9,11,13H,3,6-7,10H2,1-2H3,(H,20,21) JMFUODYQAAMVIK-UHFFFAOYSA-N 50338270 CHEMBL1681994::ethyl 4-cyclopropyl-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 9620 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338270&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53326484 125088372 CHEMBL1681994 ZINC14687377 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626362 CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C(F)(F)F InChI=1S/C17H16F3NO4S/c1-3-25-16(23)14-12(17(18,19)20)9-26-15(14)21-13(22)8-10-4-6-11(24-2)7-5-10/h4-7,9H,3,8H2,1-2H3,(H,21,22) RBMVEUBRPUKTBV-UHFFFAOYSA-N 50338271 CHEMBL1681995::ethyl 2-(2-(4-methoxyphenyl)acetamido)-4-(trifluoromethyl)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 38800 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338271&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317337 125088373 CHEMBL1681995 ZINC66073810 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626363 CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C#N InChI=1S/C17H16N2O4S/c1-3-23-17(21)15-12(9-18)10-24-16(15)19-14(20)8-11-4-6-13(22-2)7-5-11/h4-7,10H,3,8H2,1-2H3,(H,19,20) JTVHPFGRRUKYMR-UHFFFAOYSA-N 50338272 CHEMBL1681996::ethyl 4-cyano-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 310 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338272&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53322570 125088374 CHEMBL1681996 ZINC66073811 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626364 CCOC(=O)c1c(NC(=O)Cc2ccc(OC)cc2)scc1C#C InChI=1S/C18H17NO4S/c1-4-13-11-24-17(16(13)18(21)23-5-2)19-15(20)10-12-6-8-14(22-3)9-7-12/h1,6-9,11H,5,10H2,2-3H3,(H,19,20) DUBZBFMLYCNCJW-UHFFFAOYSA-N 50338273 CHEMBL1681997::ethyl 4-ethynyl-2-(2-(4-methoxyphenyl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 3020 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338273&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317338 125088375 CHEMBL1681997 ZINC66073812 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626365 COC(=O)c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1 InChI=1S/C20H18N2O3S/c1-13-12-26-19(18(13)20(24)25-2)22-17(23)11-14-3-5-15(6-4-14)16-7-9-21-10-8-16/h3-10,12H,11H2,1-2H3,(H,22,23) MZFRCQRBHBNGFV-UHFFFAOYSA-N 50338274 CHEMBL1681998::methyl 4-methyl-2-(2-(4-(pyridin-4-yl)phenyl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 263 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338274&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 45104966 125088376 CHEMBL1681998 ZINC66073813 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626366 COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCn2ccnc2)cc1 InChI=1S/C21H23N3O4S/c1-15-13-29-20(19(15)21(26)27-2)23-18(25)12-16-4-6-17(7-5-16)28-11-3-9-24-10-8-22-14-24/h4-8,10,13-14H,3,9,11-12H2,1-2H3,(H,23,25) DIUBLEYZTHWMDJ-UHFFFAOYSA-N 50338275 CHEMBL1681999::methyl 2-(2-(4-(3-(1H-imidazol-1-yl)propoxy)phenyl)acetamido)-4-methylthiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 504 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338275&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317339 125088377 CHEMBL1681999 ZINC66066453 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626367 COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCCC2)cc1 InChI=1S/C23H30N2O4S/c1-17-16-30-22(21(17)23(27)28-2)24-20(26)15-18-7-9-19(10-8-18)29-14-6-13-25-11-4-3-5-12-25/h7-10,16H,3-6,11-15H2,1-2H3,(H,24,26) IOBZIJYYPWNRQU-UHFFFAOYSA-N 50338276 CHEMBL1682000::methyl 4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 99 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338276&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53319944 125088378 CHEMBL1682000 ZINC66074085 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626368 COC(=O)c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCC2)cc1 InChI=1S/C22H28N2O4S/c1-16-15-29-21(20(16)22(26)27-2)23-19(25)14-17-6-8-18(9-7-17)28-13-5-12-24-10-3-4-11-24/h6-9,15H,3-5,10-14H2,1-2H3,(H,23,25) ZWGQEKKQEUZQBU-UHFFFAOYSA-N 50338277 CHEMBL1682001::methyl 4-methyl-2-(2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 226 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338277&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317340 125088379 CHEMBL1682001 ZINC66157300 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626369 COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cc[nH]c12 InChI=1S/C17H16N2O3S/c1-10-9-23-16(14(10)17(21)22-2)19-13(20)8-12-5-3-4-11-6-7-18-15(11)12/h3-7,9,18H,8H2,1-2H3,(H,19,20) SJNCXKGDCBKLHV-UHFFFAOYSA-N 50338278 CHEMBL1682002::methyl 2-(2-(1H-indol-7-yl)acetamido)-4-methylthiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 1020 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338278&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53319945 125088380 CHEMBL1682002 ZINC66074086 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626370 COC(=O)c1c(C)csc1NC(=O)Cc1cccc2nccnc12 InChI=1S/C17H15N3O3S/c1-10-9-24-16(14(10)17(22)23-2)20-13(21)8-11-4-3-5-12-15(11)19-7-6-18-12/h3-7,9H,8H2,1-2H3,(H,20,21) PNTONLVXRZCBPB-UHFFFAOYSA-N 50338279 CHEMBL1682003::methyl 4-methyl-2-(2-(quinoxalin-5-yl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 162 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338279&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53323911 125088381 CHEMBL1682003 ZINC66074087 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626371 COC(=O)c1c(C)csc1NC(=O)Cc1cccc2ncccc12 InChI=1S/C18H16N2O3S/c1-11-10-24-17(16(11)18(22)23-2)20-15(21)9-12-5-3-7-14-13(12)6-4-8-19-14/h3-8,10H,9H2,1-2H3,(H,20,21) YKQSOUXCRZONQQ-UHFFFAOYSA-N 50338280 CHEMBL1682004::methyl 4-methyl-2-(2-(quinolin-5-yl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338280&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53325188 125088382 CHEMBL1682004 ZINC66074088 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626372 COC(=O)c1c(C)csc1NC(=O)Cc1cccc2cnccc12 InChI=1S/C18H16N2O3S/c1-11-10-24-17(16(11)18(22)23-2)20-15(21)8-12-4-3-5-13-9-19-7-6-14(12)13/h3-7,9-10H,8H2,1-2H3,(H,20,21) YAOWLMDOOICXCZ-UHFFFAOYSA-N 50338281 CHEMBL1681791::methyl 2-(2-(isoquinolin-5-yl)acetamido)-4-methylthiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 62 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338281&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53318506 125088383 CHEMBL1681791 ZINC66074089 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626373 COC(=O)c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12 InChI=1S/C18H18N2O4S/c1-11-10-25-17(16(11)18(23)24-2)19-14(21)9-20-13-6-4-3-5-12(13)7-8-15(20)22/h3-6,10H,7-9H2,1-2H3,(H,19,21) VYQHPOVDIRILEA-UHFFFAOYSA-N 50338282 CHEMBL1682005::methyl 4-methyl-2-(2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamido)thiophene-3-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 125 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338282&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53322984 125088384 CHEMBL1682005 ZINC66098565 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626374 COc1ccc(CC(=O)Nc2scc(C)c2-c2nnc(C)[nH]2)cc1 InChI=1S/C17H18N4O2S/c1-10-9-24-17(15(10)16-18-11(2)20-21-16)19-14(22)8-12-4-6-13(23-3)7-5-12/h4-7,9H,8H2,1-3H3,(H,19,22)(H,18,20,21) LXZLCVFQXWMBJR-UHFFFAOYSA-N 50338283 2-(4-methoxyphenyl)-N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)acetamide::CHEMBL1682006 Mitogen-activated protein kinase 10 Homo sapiens 465 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338283&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869672 125088385 CHEMBL1682006 ZINC66079861 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626375 Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1 InChI=1S/C21H19N5OS/c1-13-12-28-21(19(13)20-23-14(2)25-26-20)24-18(27)11-15-3-5-16(6-4-15)17-7-9-22-10-8-17/h3-10,12H,11H2,1-2H3,(H,24,27)(H,23,25,26) LRMJMUNRVWCGNU-UHFFFAOYSA-N 50338284 CHEMBL1682007::N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(4-(pyridin-4-yl)phenyl)acetamide::US9796706, Compound 38 Mitogen-activated protein kinase 10 Homo sapiens 324 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338284&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868855 125088386 CHEMBL1682007 ZINC66079863 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626376 Cc1csc(NC(=O)Cc2ccc(OCCCN3CCCCC3)cc2)c1-c1nnc(C)[nH]1 InChI=1S/C24H31N5O2S/c1-17-16-32-24(22(17)23-25-18(2)27-28-23)26-21(30)15-19-7-9-20(10-8-19)31-14-6-13-29-11-4-3-5-12-29/h7-10,16H,3-6,11-15H2,1-2H3,(H,26,30)(H,25,27,28) JXLXJDMNSAFVFP-UHFFFAOYSA-N 50338285 CHEMBL1682008::N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 197 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338285&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869876 125088387 CHEMBL1682008 ZINC66079866 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626377 Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2nccnc12 InChI=1S/C18H16N6OS/c1-10-9-26-18(15(10)17-21-11(2)23-24-17)22-14(25)8-12-4-3-5-13-16(12)20-7-6-19-13/h3-7,9H,8H2,1-2H3,(H,22,25)(H,21,23,24) UBQAXNUSTYBVJI-UHFFFAOYSA-N 50338286 CHEMBL1682009::N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinoxalin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 594 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338286&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869815 125088388 CHEMBL1682009 ZINC66079868 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626378 Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1cccc2ncccc12 InChI=1S/C19H17N5OS/c1-11-10-26-19(17(11)18-21-12(2)23-24-18)22-16(25)9-13-5-3-7-15-14(13)6-4-8-20-15/h3-8,10H,9H2,1-2H3,(H,22,25)(H,21,23,24) YPUXXNJBUOZMOQ-UHFFFAOYSA-N 50338287 CHEMBL1682010::N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338287&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869817 125088389 CHEMBL1682010 ZINC66079870 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626379 Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1nnc[nH]1 InChI=1S/C18H15N5OS/c1-11-9-25-18(16(11)17-20-10-21-23-17)22-15(24)8-12-4-2-6-14-13(12)5-3-7-19-14/h2-7,9-10H,8H2,1H3,(H,22,24)(H,20,21,23) HQBDXBBDGWHRLC-UHFFFAOYSA-N 50338288 CHEMBL1682011::N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 143 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338288&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869745 125088390 CHEMBL1682011 ZINC66166544 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626380 Cc1nnc([nH]1)-c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12 InChI=1S/C19H19N5O2S/c1-11-10-27-19(17(11)18-20-12(2)22-23-18)21-15(25)9-24-14-6-4-3-5-13(14)7-8-16(24)26/h3-6,10H,7-9H2,1-2H3,(H,21,25)(H,20,22,23) UNUTTXCETMYXRD-UHFFFAOYSA-N 50338289 CHEMBL1682012::N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338289&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869674 125088391 CHEMBL1682012 ZINC66077417 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626381 Cc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1 InChI=1S/C18H17N5O2S/c1-11-9-26-18(16(11)17-19-10-20-22-17)21-14(24)8-23-13-5-3-2-4-12(13)6-7-15(23)25/h2-5,9-10H,6-8H2,1H3,(H,21,24)(H,19,20,22) HJUDFJRTVGXBRF-UHFFFAOYSA-N 50338290 CHEMBL1614820::N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::N-[4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338290&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869741 125088392 CHEMBL1614820 ZINC64750476 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626382 Brc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1 InChI=1S/C17H14BrN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22) JCKBTQZTGPJTII-UHFFFAOYSA-N 50338291 CHEMBL1682013::N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 28 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338291&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869882 125088393 CHEMBL1682013 ZINC66167134 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626383 Clc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1 InChI=1S/C17H14ClN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22) ZOUZXNPDTXVSEH-UHFFFAOYSA-N 50338292 CHEMBL1682014::N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338292&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869673 125088394 CHEMBL1682014 ZINC66077418 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50626384 O=C(CN1C(=O)CCc2ccccc12)Nc1scc(C#N)c1-c1nnc[nH]1 InChI=1S/C18H14N6O2S/c19-7-12-9-27-18(16(12)17-20-10-21-23-17)22-14(25)8-24-13-4-2-1-3-11(13)5-6-15(24)26/h1-4,9-10H,5-6,8H2,(H,22,25)(H,20,21,23) WNRCGOJLZOLSJN-UHFFFAOYSA-N 50338293 CHEMBL1682015::N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2011.01.046 10.7270/Q2Q52PX0 21316234 Bowers, S; Truong, AP; Neitz, RJ; Neitzel, M; Probst, GD; Hom, RK; Peterson, B; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Yao, N; Artis, DR; Brigham, EF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338293&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869880 125088395 CHEMBL1682015 ZINC66077420 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616065 O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)-c1ccccn1 InChI=1S/C27H24N6O2/c34-27-32(23-9-8-19-5-1-2-6-20(19)17-23)26(31-33(27)25-7-3-4-13-29-25)21-10-14-28-24(18-21)30-22-11-15-35-16-12-22/h1-10,13-14,17-18,22H,11-12,15-16H2,(H,28,30) YPAADIPEHKVUEJ-UHFFFAOYSA-N 50333981 4-(naphthalen-2-yl)-1-(pyridin-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644641 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333981&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53325286 125084083 CHEMBL1644641 ZINC66252530 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616068 O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)C1CC1 InChI=1S/C21H17N5O2/c27-20(14-5-6-14)23-18-12-16(9-10-22-18)19-24-25-21(28)26(19)17-8-7-13-3-1-2-4-15(13)11-17/h1-4,7-12,14H,5-6H2,(H,25,28)(H,22,23,27) LTKLQMAKAFTREX-UHFFFAOYSA-N 50333984 CHEMBL1644630::N-(4-(4-(naphthalen-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)cyclopropanecarboxamide Mitogen-activated protein kinase 10 Homo sapiens 120 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333984&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53321334 125084086 CHEMBL1644630 ZINC66058787 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616069 O=c1[nH]nc(-c2ccnc(NC3CCCC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C22H21N5O/c28-22-26-25-21(17-11-12-23-20(14-17)24-18-7-3-4-8-18)27(22)19-10-9-15-5-1-2-6-16(15)13-19/h1-2,5-6,9-14,18H,3-4,7-8H2,(H,23,24)(H,26,28) XMMMRYGZMVXRBI-UHFFFAOYSA-N 50333985 3-(2-(cyclopentylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644621 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333985&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53322644 125084087 CHEMBL1644621 ZINC66259484 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616070 O=c1[nH]nc(-c2ccnc(NC3CC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C20H17N5O/c26-20-24-23-19(15-9-10-21-18(12-15)22-16-6-7-16)25(20)17-8-5-13-3-1-2-4-14(13)11-17/h1-5,8-12,16H,6-7H2,(H,21,22)(H,24,26) UCPDQFHGSDFSKX-UHFFFAOYSA-N 50333986 3-(2-(cyclopropylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644623 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333986&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53325284 125084088 CHEMBL1644623 ZINC66259354 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616074 O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCNCC1 InChI=1S/C27H30N6O2/c34-27-32(24-6-5-19-3-1-2-4-20(19)17-24)26(31-33(27)23-8-12-28-13-9-23)21-7-14-29-25(18-21)30-22-10-15-35-16-11-22/h1-7,14,17-18,22-23,28H,8-13,15-16H2,(H,29,30) ZNDOZPHFIVKNGZ-UHFFFAOYSA-N 50333988 4-(naphthalen-2-yl)-1-(piperidin-4-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644643 Mitogen-activated protein kinase 10 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333988&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53326558 125084090 CHEMBL1644643 ZINC66251513 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616077 O=c1[nH]nc(-c2ccnc(Nc3nccs3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C20H14N6OS/c27-20-25-24-18(15-7-8-21-17(12-15)23-19-22-9-10-28-19)26(20)16-6-5-13-3-1-2-4-14(13)11-16/h1-12H,(H,25,27)(H,21,22,23) NDINXVZGAZZFMK-UHFFFAOYSA-N 50333991 4-(naphthalen-2-yl)-3-(2-(thiazol-2-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644627 Mitogen-activated protein kinase 10 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333991&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317414 125084093 CHEMBL1644627 ZINC66263182 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616079 O=c1[nH]nc(-c2ccnc(Nc3cccnc3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-11-24-20(13-17)25-18-6-3-10-23-14-18/h1-14H,(H,24,25)(H,27,29) XYVNGBDEDFMYEK-UHFFFAOYSA-N 50333993 4-(naphthalen-2-yl)-3-(2-(pyridin-3-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644626 Mitogen-activated protein kinase 10 Homo sapiens 250 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333993&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53321577 125084095 CHEMBL1644626 ZINC66263178 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616081 CCN1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O InChI=1S/C29H34N6O2/c1-2-33-15-10-25(11-16-33)35-29(36)34(26-8-7-21-5-3-4-6-22(21)19-26)28(32-35)23-9-14-30-27(20-23)31-24-12-17-37-18-13-24/h3-9,14,19-20,24-25H,2,10-13,15-18H2,1H3,(H,30,31) XCLWYSXFGKFXNA-UHFFFAOYSA-N 50333995 1-(1-ethylpiperidin-4-yl)-4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644644 Mitogen-activated protein kinase 10 Homo sapiens 280 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333995&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53325287 125084097 CHEMBL1644644 ZINC66251713 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616087 CC(=O)Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1 InChI=1S/C19H15N5O2/c1-12(25)21-17-11-15(8-9-20-17)18-22-23-19(26)24(18)16-7-6-13-4-2-3-5-14(13)10-16/h2-11H,1H3,(H,23,26)(H,20,21,25) HCFNWGLCDCAOAC-UHFFFAOYSA-N 50333999 CHEMBL1644629::N-(4-(4-(naphthalen-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 410 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333999&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53321333 125084101 CHEMBL1644629 ZINC66263188 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616090 Brc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1 InChI=1S/C22H20BrN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29) CUTRCHHQYWQMFT-UHFFFAOYSA-N 50334002 4-(6-bromonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644634 Mitogen-activated protein kinase 10 Homo sapiens 430 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334002&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53323987 125084104 CHEMBL1644634 ZINC66262074 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616095 O=C(Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1 InChI=1S/C24H17N5O2/c30-23(17-7-2-1-3-8-17)26-21-15-19(12-13-25-21)22-27-28-24(31)29(22)20-11-10-16-6-4-5-9-18(16)14-20/h1-15H,(H,28,31)(H,25,26,30) WDMFJZXLYDZRPT-UHFFFAOYSA-N 50334005 CHEMBL1644631::N-(4-(4-(naphthalen-2-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridin-2-yl)benzamide Mitogen-activated protein kinase 10 Homo sapiens 590 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334005&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317415 125084107 CHEMBL1644631 ZINC66058788 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616102 Nc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1 InChI=1S/C22H22N6O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10,23H2,(H,24,25)(H,27,29) IIKSDWUGCLXLNR-UHFFFAOYSA-N 50334006 4-(6-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644633 Mitogen-activated protein kinase 10 Homo sapiens 950 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334006&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53326557 125084108 CHEMBL1644633 ZINC66262072 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616105 Clc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1 InChI=1S/C22H20ClN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29) TTXQZIOMYONUEL-UHFFFAOYSA-N 50333983 4-(8-chloronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644637 Mitogen-activated protein kinase 10 Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333983&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53323988 125084085 CHEMBL1644637 ZINC66252781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616106 O=c1n(nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1)C1CCOCC1 InChI=1S/C28H31N5O2/c34-28-32(25-11-10-20-6-4-5-7-21(20)18-25)27(31-33(28)24-13-16-35-17-14-24)22-12-15-29-26(19-22)30-23-8-2-1-3-9-23/h4-7,10-12,15,18-19,23-24H,1-3,8-9,13-14,16-17H2,(H,29,30) YZJYYYWPZRYBLV-UHFFFAOYSA-N 50334001 3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644639 Mitogen-activated protein kinase 10 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334001&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 589 3OY1 50941538 125084103 CHEMBL1644639 ZINC66252527 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616107 O=c1n(CC2CCOCC2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C29H33N5O2/c35-29-33(20-21-13-16-36-17-14-21)32-28(34(29)26-11-10-22-6-4-5-7-23(22)18-26)24-12-15-30-27(19-24)31-25-8-2-1-3-9-25/h4-7,10-12,15,18-19,21,25H,1-3,8-9,13-14,16-17,20H2,(H,30,31) DXTYYUXUIQZDHR-UHFFFAOYSA-N 50334000 3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644638 Mitogen-activated protein kinase 10 Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334000&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53323989 125084102 CHEMBL1644638 ZINC66252782 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616108 O=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C23H23N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h4-7,10-15,19H,1-3,8-9H2,(H,24,25)(H,27,29) IJTANTDZFOCBKK-UHFFFAOYSA-N 50334008 3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644618 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334008&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 50941455 125084110 CHEMBL1644618 ZINC66251999 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616109 COC(=O)N1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O InChI=1S/C29H32N6O4/c1-38-29(37)33-14-9-24(10-15-33)35-28(36)34(25-7-6-20-4-2-3-5-21(20)18-25)27(32-35)22-8-13-30-26(19-22)31-23-11-16-39-17-12-23/h2-8,13,18-19,23-24H,9-12,14-17H2,1H3,(H,30,31) QKJMPSJTHLLZPU-UHFFFAOYSA-N 50333997 CHEMBL1644646::methyl 4-(4-(naphthalen-2-yl)-5-oxo-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl)piperidine-1-carboxylate Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333997&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53325288 125084099 CHEMBL1644646 ZINC66258682 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616110 O=c1n(Cc2ccncc2)nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C29H28N6O/c36-29-34(20-21-12-15-30-16-13-21)33-28(35(29)26-11-10-22-6-4-5-7-23(22)18-26)24-14-17-31-27(19-24)32-25-8-2-1-3-9-25/h4-7,10-19,25H,1-3,8-9,20H2,(H,31,32) IOZQORJWOUBHKH-UHFFFAOYSA-N 50333980 3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1-(pyridin-4-ylmethyl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644642 Mitogen-activated protein kinase 10 Homo sapiens 29 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333980&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 50941539 125084082 CHEMBL1644642 ZINC66251512 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616111 O=c1[nH]nc(-c2ccnc(NC3CCCOC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-8-7-15-4-1-2-5-16(15)12-19)17-9-10-23-20(13-17)24-18-6-3-11-29-14-18/h1-2,4-5,7-10,12-13,18H,3,6,11,14H2,(H,23,24)(H,26,28) WTYOGZPSBLDMQY-UHFFFAOYSA-N 50333987 4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-3-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644619 Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333987&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53326555 125084089 CHEMBL1644619 ZINC66252770 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616112 FC(F)(F)CN1CCC(CC1)n1nc(-c2ccnc(NC3CCOCC3)c2)n(-c2ccc3ccccc3c2)c1=O InChI=1S/C29H31F3N6O2/c30-29(31,32)19-36-13-8-24(9-14-36)38-28(39)37(25-6-5-20-3-1-2-4-21(20)17-25)27(35-38)22-7-12-33-26(18-22)34-23-10-15-40-16-11-23/h1-7,12,17-18,23-24H,8-11,13-16,19H2,(H,33,34) SRTMONQYBOXBGE-UHFFFAOYSA-N 50333989 4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644645 Mitogen-activated protein kinase 10 Homo sapiens 36 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333989&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317417 125084091 CHEMBL1644645 ZINC66258429 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616113 O=c1[nH]nc(-c2ccnc(Nc3ccccn3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C22H16N6O/c29-22-27-26-21(28(22)18-9-8-15-5-1-2-6-16(15)13-18)17-10-12-24-20(14-17)25-19-7-3-4-11-23-19/h1-14H,(H,27,29)(H,23,24,25) PSUZEBSSYLZYCL-UHFFFAOYSA-N 50333982 4-(naphthalen-2-yl)-3-(2-(pyridin-2-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644625 Mitogen-activated protein kinase 10 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333982&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317413 125084084 CHEMBL1644625 ZINC66259487 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616114 Fc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1 InChI=1S/C22H20FN5O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11H2,(H,24,25)(H,27,29) AQGSJPJSRCAJNS-UHFFFAOYSA-N 50333998 4-(8-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644635 Mitogen-activated protein kinase 10 Homo sapiens 54 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333998&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53318709 125084100 CHEMBL1644635 ZINC66252779 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616115 O=c1n(Cc2ccccn2)nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C28H26N6O2/c35-28-33(19-24-7-3-4-13-29-24)32-27(34(28)25-9-8-20-5-1-2-6-21(20)17-25)22-10-14-30-26(18-22)31-23-11-15-36-16-12-23/h1-10,13-14,17-18,23H,11-12,15-16,19H2,(H,30,31) OHUXKIXTONEVBL-UHFFFAOYSA-N 50334007 4-(naphthalen-2-yl)-1-(pyridin-2-ylmethyl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644615 Mitogen-activated protein kinase 10 Homo sapiens 54 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334007&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53325283 125084109 CHEMBL1644615 ZINC66251997 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616117 O=c1[nH]nc(-c2ccnc(Nc3ccccc3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C23H17N5O/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h1-15H,(H,24,25)(H,27,29) ZRSKGCIFXQCBBO-UHFFFAOYSA-N 50334003 4-(naphthalen-2-yl)-3-(2-(phenylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644624 Mitogen-activated protein kinase 10 Homo sapiens 61 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334003&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53326556 125084105 CHEMBL1644624 ZINC66259486 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616120 O=c1[nH]nc(-c2ccnc(NC3CCC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C21H19N5O/c27-21-25-24-20(16-10-11-22-19(13-16)23-17-6-3-7-17)26(21)18-9-8-14-4-1-2-5-15(14)12-18/h1-2,4-5,8-13,17H,3,6-7H2,(H,22,23)(H,25,27) NUEDKDFHLPVYRY-UHFFFAOYSA-N 50333992 3-(2-(cyclobutylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644622 Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333992&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53323986 125084094 CHEMBL1644622 ZINC66259485 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616121 Fc1ccc2cc(ccc2c1)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1 InChI=1S/C22H20FN5O2/c23-17-3-1-15-12-19(4-2-14(15)11-17)28-21(26-27-22(28)29)16-5-8-24-20(13-16)25-18-6-9-30-10-7-18/h1-5,8,11-13,18H,6-7,9-10H2,(H,24,25)(H,27,29) PXOJJCCSYAVCPK-UHFFFAOYSA-N 50333990 4-(6-fluoronaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644632 Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333990&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53322645 125084092 CHEMBL1644632 ZINC66058789 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616122 O=c1[nH]nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C22H21N5O2/c28-22-26-25-21(27(22)19-6-5-15-3-1-2-4-16(15)13-19)17-7-10-23-20(14-17)24-18-8-11-29-12-9-18/h1-7,10,13-14,18H,8-9,11-12H2,(H,23,24)(H,26,28) LCBNUBGZQBBNPG-UHFFFAOYSA-N 50333994 4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644620 Mitogen-activated protein kinase 10 Homo sapiens 85 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333994&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53323985 125084096 CHEMBL1644620 ZINC66259483 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616123 O=c1n(nc(-c2ccnc(NC3CCOCC3)c2)n1-c1ccc2ccccc2c1)C1CCOC1 InChI=1S/C26H27N5O3/c32-26-30(22-6-5-18-3-1-2-4-19(18)15-22)25(29-31(26)23-10-14-34-17-23)20-7-11-27-24(16-20)28-21-8-12-33-13-9-21/h1-7,11,15-16,21,23H,8-10,12-14,17H2,(H,27,28) JPTYCOMKVYISJL-UHFFFAOYSA-N 50333996 4-(naphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644640 Mitogen-activated protein kinase 10 Homo sapiens 92 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333996&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317416 125084098 CHEMBL1644640 ZINC66252529 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616125 Nc1cccc2ccc(cc12)-n1c(n[nH]c1=O)-c1ccnc(NC2CCOCC2)c1 InChI=1S/C22H22N6O2/c23-19-3-1-2-14-4-5-17(13-18(14)19)28-21(26-27-22(28)29)15-6-9-24-20(12-15)25-16-7-10-30-11-8-16/h1-6,9,12-13,16H,7-8,10-11,23H2,(H,24,25)(H,27,29) GBKQNVNYZATRQE-UHFFFAOYSA-N 50334004 4-(8-aminonaphthalen-2-yl)-3-(2-(tetrahydro-2H-pyran-4-ylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644636 Mitogen-activated protein kinase 10 Homo sapiens 94 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334004&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53325285 125084106 CHEMBL1644636 ZINC66252780 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616137 CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1 InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33) UQFRSHRWRKYNDE-UHFFFAOYSA-N 16016 CHEMBL437747::N-cyclohexyl-4-[4-(3,4-dichlorophenyl)-2-(piperidin-4-yl)-1-propyl-1H-imidazol-5-yl]pyrimidin-2-amine::N-cyclohexyl-4-[4-(3,4-dichlorophenyl)-2-piperidin-4-yl-1-propyl-1H-imidazol-5-yl]pyrimidin-2-amine::imidazole-pyrimidine compound 2 Mitogen-activated protein kinase 10 Homo sapiens 1.6 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16016&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 880 4Z9L 447873 46516285 CHEMBL437747 DB02388 ZINC12501995 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616146 C[C@H](Nc1cc(ccn1)-c1n[nH]c(=O)n1-c1ccc2ccccc2c1)c1ccccc1 InChI=1S/C25H21N5O/c1-17(18-7-3-2-4-8-18)27-23-16-21(13-14-26-23)24-28-29-25(31)30(24)22-12-11-19-9-5-6-10-20(19)15-22/h2-17H,1H3,(H,26,27)(H,29,31)/t17-/m0/s1 SSWRNLLUXXNMGJ-KRWDZBQOSA-N 50334010 (S)-4-(naphthalen-2-yl)-3-(2-(1-phenylethylamino)pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644628 Mitogen-activated protein kinase 10 Homo sapiens 3900 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334010&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53320021 125084112 CHEMBL1644628 ZINC66263184 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50616158 O=c1[nH]nc(-c2ccncc2)n1-c1ccc2ccccc2c1 InChI=1S/C17H12N4O/c22-17-20-19-16(13-7-9-18-10-8-13)21(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,(H,20,22) BITKQUYZUVMDIL-UHFFFAOYSA-N 50334009 4-(naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-triazol-5(4H)-one::CHEMBL1644617 Mitogen-activated protein kinase 10 Homo sapiens 16000 ChEMBL 10.1016/j.bmcl.2010.11.010 10.7270/Q24F1R0T 21112785 Probst, GD; Bowers, S; Sealy, JM; Truong, AP; Hom, RK; Galemmo, RA; Konradi, AW; Sham, HL; Quincy, DA; Pan, H; Yao, N; Lin, M; Toth, G; Artis, DR; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, DF; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Wright, S; Chereau, D; Ren, Z; Anderson, JP; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50334009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50334009&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53317412 125084111 CHEMBL1644617 ZINC66251998 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636298 Cc1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cc[nH]n2)cc1 InChI=1S/C16H14N8/c1-11-18-10-24(23-11)13-4-2-12(3-5-13)20-16-17-8-6-14(21-16)15-7-9-19-22-15/h2-10H,1H3,(H,19,22)(H,17,20,21) WKOVHPNOMHQDPN-UHFFFAOYSA-N 50342479 CHEMBL1771656::N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1H-pyrazol-3-yl)pyrimidin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 630 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342479&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587504 131345415 CHEMBL1771656 ZINC71341302 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636299 Cc1ncn(n1)-c1ccc(Nc2nccc(n2)-c2ccn(C)n2)cc1 InChI=1S/C17H16N8/c1-12-19-11-25(22-12)14-5-3-13(4-6-14)20-17-18-9-7-15(21-17)16-8-10-24(2)23-16/h3-11H,1-2H3,(H,18,20,21) LGVKKVOTWKJMJB-UHFFFAOYSA-N 50342480 CHEMBL1771657::N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1-methyl-1H-pyrazol-3-yl)pyrimidin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 1450 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342480&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581623 131345416 CHEMBL1771657 ZINC71340491 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636300 Cc1ncn(n1)-c1ccc(Nc2ncc(Cl)c(n2)-c2ccn(C)n2)cc1 InChI=1S/C17H15ClN8/c1-11-20-10-26(23-11)13-5-3-12(4-6-13)21-17-19-9-14(18)16(22-17)15-7-8-25(2)24-15/h3-10H,1-2H3,(H,19,21,22) HSCCUEDIVBEGIJ-UHFFFAOYSA-N 50342481 5-chloro-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1-methyl-1H-pyrazol-3-yl)pyrimidin-2-amine::CHEMBL1771658 Mitogen-activated protein kinase 10 Homo sapiens 860 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342481&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586474 131345417 CHEMBL1771658 ZINC71340428 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636301 Cn1ccc(n1)-c1nc(Nc2ccc(cc2)-n2cnc(n2)N2CCOCC2)ncc1Cl InChI=1S/C20H20ClN9O/c1-28-7-6-17(26-28)18-16(21)12-22-19(25-18)24-14-2-4-15(5-3-14)30-13-23-20(27-30)29-8-10-31-11-9-29/h2-7,12-13H,8-11H2,1H3,(H,22,24,25) MJKVCXQYWZTOGF-UHFFFAOYSA-N 50342482 5-chloro-4-(1-methyl-1H-pyrazol-3-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine::CHEMBL1771659 Mitogen-activated protein kinase 10 Homo sapiens 730 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342482&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584562 131345418 CHEMBL1771659 ZINC71334443 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643714 S=c1[nH]nc(-c2ccncc2)n1-c1ccc2ccccc2c1 InChI=1S/C17H12N4S/c22-17-20-19-16(13-7-9-18-10-8-13)21(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,(H,20,22) WGSPDZRJWDJTFY-UHFFFAOYSA-N 50345609 4-(naphthalen-2-yl)-3-(pyridin-4-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1644616 Mitogen-activated protein kinase 10 Homo sapiens 559 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345609&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3659633 131348540 CHEMBL1644616 ZINC05332367 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643715 S=c1[nH]nc(-c2ccncc2)n1-c1cnc2ccccc2c1 InChI=1S/C16H11N5S/c22-16-20-19-15(11-5-7-17-8-6-11)21(16)13-9-12-3-1-2-4-14(12)18-10-13/h1-10H,(H,20,22) HZCNXMGYWVMCDF-UHFFFAOYSA-N 50345610 3-(pyridin-4-yl)-4-(quinolin-3-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1784643 Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345610&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581359 131348541 CHEMBL1784643 ZINC71281809 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643716 Cc1cc(ccn1)-c1n[nH]c(=S)n1-c1ccc2ccccc2c1 InChI=1S/C18H14N4S/c1-12-10-15(8-9-19-12)17-20-21-18(23)22(17)16-7-6-13-4-2-3-5-14(13)11-16/h2-11H,1H3,(H,21,23) JGWBLISHUBMWNZ-UHFFFAOYSA-N 50345611 3-(2-methylpyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1784644 Mitogen-activated protein kinase 10 Homo sapiens 14800 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345611&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585285 131348542 CHEMBL1784644 ZINC71294756 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643717 Cc1cc(ccn1)-c1n[nH]c(=S)n1-c1cnc2ccccc2c1 InChI=1S/C17H13N5S/c1-11-8-13(6-7-18-11)16-20-21-17(23)22(16)14-9-12-4-2-3-5-15(12)19-10-14/h2-10H,1H3,(H,21,23) SQXGKHIWIOQBSM-UHFFFAOYSA-N 50345612 3-(2-methylpyridin-4-yl)-4-(quinolin-3-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1784645 Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345612&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585286 131348543 CHEMBL1784645 ZINC71282348 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643718 Fc1cnccc1-c1n[nH]c(=S)n1-c1ccc2ccccc2c1 InChI=1S/C17H11FN4S/c18-15-10-19-8-7-14(15)16-20-21-17(23)22(16)13-6-5-11-3-1-2-4-12(11)9-13/h1-10H,(H,21,23) DHNCPDAAQLFCGP-UHFFFAOYSA-N 50345613 3-(3-fluoropyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1784646 Mitogen-activated protein kinase 10 Homo sapiens 27400 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345613&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587258 131348544 CHEMBL1784646 ZINC71294859 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643719 Brc1cc(ccn1)-c1n[nH]c(=S)n1-c1ccc2ccccc2c1 InChI=1S/C17H11BrN4S/c18-15-10-13(7-8-19-15)16-20-21-17(23)22(16)14-6-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,21,23) PBENNVNCWMGDNJ-UHFFFAOYSA-N 50345614 3-(2-bromopyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1784647 Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345614&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585287 131348545 CHEMBL1784647 ZINC71281033 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643720 S=c1[nH]nc(-c2ccncc2)n1-c1ccc2ncccc2c1 InChI=1S/C16H11N5S/c22-16-20-19-15(11-5-8-17-9-6-11)21(16)13-3-4-14-12(10-13)2-1-7-18-14/h1-10H,(H,20,22) LBFHENIQUZDDQR-UHFFFAOYSA-N 50345615 3-(pyridin-4-yl)-4-(quinolin-6-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1784648 Mitogen-activated protein kinase 10 Homo sapiens 31800 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345615&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 942437 131348546 CHEMBL1784648 ZINC05927247 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643721 Nc1cc(ccn1)-c1n[nH]c(=S)n1-c1ccc2ccccc2c1 InChI=1S/C17H13N5S/c18-15-10-13(7-8-19-15)16-20-21-17(23)22(16)14-6-5-11-3-1-2-4-12(11)9-14/h1-10H,(H2,18,19)(H,21,23) LYGMDOBOTXREEY-UHFFFAOYSA-N 50345616 3-(2-aminopyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1784649 Mitogen-activated protein kinase 10 Homo sapiens 1030 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345616&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585288 131348547 CHEMBL1784649 ZINC71296060 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643722 S=c1[nH]nc(-c2ccnc(NC3CCCCC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C23H23N5S/c29-23-27-26-22(28(23)20-11-10-16-6-4-5-7-17(16)14-20)18-12-13-24-21(15-18)25-19-8-2-1-3-9-19/h4-7,10-15,19H,1-3,8-9H2,(H,24,25)(H,27,29) XIUOLJTWTRUVGZ-UHFFFAOYSA-N 50345617 3-(2-(cyclohexylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1784650 Mitogen-activated protein kinase 10 Homo sapiens 52.2 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345617&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581360 131348548 CHEMBL1784650 ZINC71281076 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643723 S=c1[nH]nc(-c2ccnc(NCC3CC3)c2)n1-c1ccc2ccccc2c1 InChI=1S/C21H19N5S/c27-21-25-24-20(17-9-10-22-19(12-17)23-13-14-5-6-14)26(21)18-8-7-15-3-1-2-4-16(15)11-18/h1-4,7-12,14H,5-6,13H2,(H,22,23)(H,25,27) KDXIUKJSJIVWEJ-UHFFFAOYSA-N 50345618 3-(2-(cyclopropylmethylamino)pyridin-4-yl)-4-(naphthalen-2-yl)-1H-1,2,4-triazole-5(4H)-thione::CHEMBL1784651 Mitogen-activated protein kinase 10 Homo sapiens 945 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345618&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584315 131348549 CHEMBL1784651 ZINC71295690 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643724 FC(F)(F)c1nnc(-c2ccncc2)n1-c1ccc2ccccc2c1 InChI=1S/C18H11F3N4/c19-18(20,21)17-24-23-16(13-7-9-22-10-8-13)25(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H GLJSXAABSWJMQO-UHFFFAOYSA-N 50345619 4-(4-(naphthalen-2-yl)-5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl)pyridine::CHEMBL1784652 Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345619&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585289 131348550 CHEMBL1784652 ZINC71281887 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643725 c1nnc(-c2ccncc2)n1-c1ccc2ccccc2c1 InChI=1S/C17H12N4/c1-2-4-15-11-16(6-5-13(15)3-1)21-12-19-20-17(21)14-7-9-18-10-8-14/h1-12H GGWAOOWYPMJNDP-UHFFFAOYSA-N 50345620 4-(4-(naphthalen-2-yl)-4H-1,2,4-triazol-3-yl)pyridine::CHEMBL1784653 Mitogen-activated protein kinase 10 Homo sapiens 4480 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345620&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581361 131348551 CHEMBL1784653 ZINC71295108 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643726 Cc1nnc(-c2ccncc2)n1-c1ccc2ccccc2c1 InChI=1S/C18H14N4/c1-13-20-21-18(15-8-10-19-11-9-15)22(13)17-7-6-14-4-2-3-5-16(14)12-17/h2-12H,1H3 VXLMULPZNRPIGQ-UHFFFAOYSA-N 50345621 4-(5-methyl-4-(naphthalen-2-yl)-4H-1,2,4-triazol-3-yl)pyridine::CHEMBL1784654 Mitogen-activated protein kinase 10 Homo sapiens 18300 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345621&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587259 131348552 CHEMBL1784654 ZINC71295160 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643727 c1ccc2cc(ccc2c1)-n1nnnc1-c1ccncc1 InChI=1S/C16H11N5/c1-2-4-14-11-15(6-5-12(14)3-1)21-16(18-19-20-21)13-7-9-17-10-8-13/h1-11H FIRFEZGHWSFFGR-UHFFFAOYSA-N 50345622 4-(1-(naphthalen-2-yl)-1H-tetrazol-5-yl)pyridine::CHEMBL1784655 Mitogen-activated protein kinase 10 Homo sapiens 49100 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345622&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586233 131348553 CHEMBL1784655 ZINC71281743 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643728 Clc1nnc(-c2ccncc2)n1-c1ccc2ccccc2c1 InChI=1S/C17H11ClN4/c18-17-21-20-16(13-7-9-19-10-8-13)22(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H FAWRPRQGLZZDPP-UHFFFAOYSA-N 50345597 4-(5-chloro-4-(naphthalen-2-yl)-4H-1,2,4-triazol-3-yl)pyridine::CHEMBL1784656 Mitogen-activated protein kinase 10 Homo sapiens 30400 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345597&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584316 131348528 CHEMBL1784656 ZINC71294515 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643729 NNc1nnc(-c2ccncc2)n1-c1ccc2ccccc2c1 InChI=1S/C17H14N6/c18-20-17-22-21-16(13-7-9-19-10-8-13)23(17)15-6-5-12-3-1-2-4-14(12)11-15/h1-11H,18H2,(H,20,22) JKYHDSFWUDAGSR-UHFFFAOYSA-N 50345598 4-(5-hydrazono-4-(naphthalen-2-yl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)pyridine::CHEMBL1784657 Mitogen-activated protein kinase 10 Homo sapiens 14900 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345598&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587260 131348529 CHEMBL1784657 ZINC71295766 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643730 Clc1nnn(c1-c1ccc2ccccc2c1)-c1ccncc1 InChI=1S/C17H11ClN4/c18-17-16(22(21-20-17)15-7-9-19-10-8-15)14-6-5-12-3-1-2-4-13(12)11-14/h1-11H YNZMOHOWKCZJJV-UHFFFAOYSA-N 50345599 4-(4-chloro-5-(naphthalen-2-yl)-1H-1,2,3-triazol-1-yl)pyridine::CHEMBL1784658 Mitogen-activated protein kinase 10 Homo sapiens 12600 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345599&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583368 131348530 CHEMBL1784658 ZINC71280813 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643731 c1nnn(c1-c1ccc2ccccc2c1)-c1ccncc1 InChI=1S/C17H12N4/c1-2-4-14-11-15(6-5-13(14)3-1)17-12-19-20-21(17)16-7-9-18-10-8-16/h1-12H HDRATJLMZLLEKE-UHFFFAOYSA-N 50345600 4-(5-(naphthalen-2-yl)-1H-1,2,3-triazol-1-yl)pyridine::CHEMBL1784659 Mitogen-activated protein kinase 10 Homo sapiens 4810 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345600&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585290 131348531 CHEMBL1784659 ZINC71281781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643732 c1cc(-c2ccc3ccccc3c2)n(n1)-c1ccncc1 InChI=1S/C18H13N3/c1-2-4-15-13-16(6-5-14(15)3-1)18-9-12-20-21(18)17-7-10-19-11-8-17/h1-13H ARZYOUBGUUXNBX-UHFFFAOYSA-N 50345601 4-(5-(naphthalen-2-yl)-2,5-dihydro-1H-pyrazol-1-yl)pyridine::CHEMBL1784660 Mitogen-activated protein kinase 10 Homo sapiens 2460 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345601&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585291 131348532 CHEMBL1784660 ZINC71294277 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643733 c1cc(-c2ccncc2)n(n1)-c1ccc2ccccc2c1 InChI=1S/C18H13N3/c1-2-4-16-13-17(6-5-14(16)3-1)21-18(9-12-20-21)15-7-10-19-11-8-15/h1-13H XOKWABHONZKNCB-UHFFFAOYSA-N 50345602 4-(1-(naphthalen-2-yl)-1H-pyrazol-5-yl)pyridine::CHEMBL1784661 Mitogen-activated protein kinase 10 Homo sapiens 1230 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345602&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581362 131348533 CHEMBL1784661 ZINC71295398 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643734 c1ccc2cc(ccc2c1)-c1nnnn1-c1ccncc1 InChI=1S/C16H11N5/c1-2-4-13-11-14(6-5-12(13)3-1)16-18-19-20-21(16)15-7-9-17-10-8-15/h1-11H UBAIOVJSAMIEER-UHFFFAOYSA-N 50345603 4-(5-(naphthalen-2-yl)-1H-tetrazol-1-yl)pyridine::CHEMBL1784662 Mitogen-activated protein kinase 10 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345603&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581363 131348534 CHEMBL1784662 ZINC71281157 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643735 c1cn(c(n1)-c1ccncc1)-c1ccc2ccccc2c1 InChI=1S/C18H13N3/c1-2-4-16-13-17(6-5-14(16)3-1)21-12-11-20-18(21)15-7-9-19-10-8-15/h1-13H QDRXGPKEZPUUTQ-UHFFFAOYSA-N 50345604 4-(1-(naphthalen-2-yl)-1H-imidazol-2-yl)pyridine::CHEMBL1784663 Mitogen-activated protein kinase 10 Homo sapiens 1910 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345604&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583369 131348535 CHEMBL1784663 ZINC71294792 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643736 c1nnn(c1-c1ccncc1)-c1ccc2ccccc2c1 InChI=1S/C17H12N4/c1-2-4-15-11-16(6-5-13(15)3-1)21-17(12-19-20-21)14-7-9-18-10-8-14/h1-12H FCDZUFRFVMBMLO-UHFFFAOYSA-N 50345605 4-(1-(naphthalen-2-yl)-1H-1,2,3-triazol-5-yl)pyridine::CHEMBL1784664 Mitogen-activated protein kinase 10 Homo sapiens 2670 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345605&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587261 131348536 CHEMBL1784664 ZINC71295836 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643737 c1ccc2cc(ccc2c1)-c1[nH]nnc1-c1ccncc1 InChI=1S/C17H12N4/c1-2-4-14-11-15(6-5-12(14)3-1)17-16(19-21-20-17)13-7-9-18-10-8-13/h1-11H,(H,19,20,21) MTQPZJROIXYNGB-UHFFFAOYSA-N 50345606 4-(4-(naphthalen-2-yl)-1H-1,2,3-triazol-5-yl)pyridine::CHEMBL1784665 Mitogen-activated protein kinase 10 Homo sapiens 364 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345606&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584317 131348537 CHEMBL1784665 ZINC71295366 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643738 c1[nH]nc(c1-c1ccncc1)-c1ccc2ccccc2c1 InChI=1S/C18H13N3/c1-2-4-15-11-16(6-5-13(15)3-1)18-17(12-20-21-18)14-7-9-19-10-8-14/h1-12H,(H,20,21) GLFSGNWAZDGYBV-UHFFFAOYSA-N 50345607 4-(5-(naphthalen-2-yl)-1H-pyrazol-4-yl)pyridine::CHEMBL1784666 Mitogen-activated protein kinase 10 Homo sapiens 245 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345607&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 53469858 131348538 CHEMBL1784666 ZINC71294690 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50643739 c1ccc2cc(ccc2c1)-c1ncncc1-c1ccncc1 InChI=1S/C19H13N3/c1-2-4-16-11-17(6-5-14(16)3-1)19-18(12-21-13-22-19)15-7-9-20-10-8-15/h1-13H FYTQPCAWJIMNQU-UHFFFAOYSA-N 50345608 4-(naphthalen-2-yl)-5-(pyridin-4-yl)pyrimidine::CHEMBL1784667 Mitogen-activated protein kinase 10 Homo sapiens 4130 ChEMBL 10.1016/j.bmcl.2011.04.074 10.7270/Q2WQ044C 21570836 Neitz, RJ; Konradi, AW; Sham, HL; Zmolek, W; Wong, K; Qin, A; Lorentzen, C; Nakamura, D; Quinn, KP; Sauer, JM; Powell, K; Ruslim, L; Chereau, D; Ren, Z; Anderson, J; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50345608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50345608&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585292 131348539 CHEMBL1784667 ZINC71281393 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50633676 Cn1c2nc(NC(CCO)CCO)ncc2cc(Oc2ccc(F)cc2F)c1=O InChI=1S/C19H20F2N4O4/c1-25-17-11(10-22-19(24-17)23-13(4-6-26)5-7-27)8-16(18(25)28)29-15-3-2-12(20)9-14(15)21/h2-3,8-10,13,26-27H,4-7H2,1H3,(H,22,23,24) JYYLVUFNAHSSFE-UHFFFAOYSA-N 50314070 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL1090089::pamapimod Mitogen-activated protein kinase 10 Homo sapiens 19 ChEMBL 10.1021/jm101423y 10.7270/Q20P109X 21375264 Goldstein, DM; Soth, M; Gabriel, T; Dewdney, N; Kuglstatter, A; Arzeno, H; Chen, J; Bingenheimer, W; Dalrymple, SA; Dunn, J; Farrell, R; Frauchiger, S; La Fargue, J; Ghate, M; Graves, B; Hill, RJ; Li, F; Litman, R; Loe, B; McIntosh, J; McWeeney, D; Papp, E; Park, J; Reese, HF; Roberts, RT; Rotstein, D; San Pablo, B; Sarma, K; Stahl, M; Sung, ML; Suttman, RT; Sjogren, EB; Tan, Y; Trejo, A; Welch, M; Weller, P; Wong, BR; Zecic, H Roche Palo Alto LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314070&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search FLW 3FLW 16220188 104148431 CHEMBL1090089 ZINC30691792 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636302 C1CN(CCO1)c1ccc(Nc2cc(ccn2)-c2cc[nH]n2)cc1 InChI=1S/C18H19N5O/c1-3-16(23-9-11-24-12-10-23)4-2-15(1)21-18-13-14(5-7-19-18)17-6-8-20-22-17/h1-8,13H,9-12H2,(H,19,21)(H,20,22) BECAQPGMCODJMW-UHFFFAOYSA-N 50342483 CHEMBL1771660::N-(4-morpholinophenyl)-4-(1H-pyrazol-3-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342483&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586475 131345419 CHEMBL1771660 ZINC71341776 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636303 Clc1cnc(Nc2ccc(cc2)N2CCOCC2)cc1-c1cc[nH]n1 InChI=1S/C18H18ClN5O/c19-16-12-20-18(11-15(16)17-5-6-21-23-17)22-13-1-3-14(4-2-13)24-7-9-25-10-8-24/h1-6,11-12H,7-10H2,(H,20,22)(H,21,23) UIZKCBMCRIOXTR-UHFFFAOYSA-N 50342484 5-chloro-N-(4-morpholinophenyl)-4-(1H-pyrazol-3-yl)pyridin-2-amine::CHEMBL1771661 Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342484&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583573 131345420 CHEMBL1771661 ZINC71405029 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636304 Cn1ccc(n1)-c1cc(Nc2ccc(cc2)N2CCOCC2)ncc1Cl InChI=1S/C19H20ClN5O/c1-24-7-6-18(23-24)16-12-19(21-13-17(16)20)22-14-2-4-15(5-3-14)25-8-10-26-11-9-25/h2-7,12-13H,8-11H2,1H3,(H,21,22) LVGLNTAMDRUXSB-UHFFFAOYSA-N 50342485 5-chloro-4-(1-methyl-1H-pyrazol-3-yl)-N-(4-morpholinophenyl)pyridin-2-amine::CHEMBL1771662 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342485&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584563 131345421 CHEMBL1771662 ZINC71342078 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636305 Cc1nc(C)n(n1)-c1ccc(Nc2cc(-c3ccn(C)n3)c(Cl)cn2)cc1 InChI=1S/C19H18ClN7/c1-12-22-13(2)27(24-12)15-6-4-14(5-7-15)23-19-10-16(17(20)11-21-19)18-8-9-26(3)25-18/h4-11H,1-3H3,(H,21,23) RPLUSWNGTMKDQG-UHFFFAOYSA-N 50342486 5-chloro-N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1-methyl-1H-pyrazol-3-yl)pyridin-2-amine::CHEMBL1771663 Mitogen-activated protein kinase 10 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342486&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584564 131345422 CHEMBL1771663 ZINC71341890 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636306 Cn1ccc(n1)-c1cc(Nc2ccc(cc2)-n2cnc(n2)N2CCOCC2)ncc1Cl InChI=1S/C21H21ClN8O/c1-28-7-6-19(26-28)17-12-20(23-13-18(17)22)25-15-2-4-16(5-3-15)30-14-24-21(27-30)29-8-10-31-11-9-29/h2-7,12-14H,8-11H2,1H3,(H,23,25) RAZZHBHHDDHDAR-UHFFFAOYSA-N 50342487 5-chloro-4-(1-methyl-1H-pyrazol-3-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyridin-2-amine::CHEMBL1771664 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342487&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583574 131345423 CHEMBL1771664 ZINC71331038 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636307 Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2cc(-c3ccn(C)n3)c(Cl)cn2)cc1 InChI=1S/C23H19ClN8/c1-15-3-4-16(12-25-15)23-27-14-32(30-23)18-7-5-17(6-8-18)28-22-11-19(20(24)13-26-22)21-9-10-31(2)29-21/h3-14H,1-2H3,(H,26,28) RFFQIFBVAAVCAW-UHFFFAOYSA-N 50342488 5-chloro-4-(1-methyl-1H-pyrazol-3-yl)-N-(4-(3-(6-methylpyridin-3-yl)-1H-1,2,4-triazol-1-yl)phenyl)pyridin-2-amine::CHEMBL1771665 Mitogen-activated protein kinase 10 Homo sapiens 600 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342488&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54580615 131345424 CHEMBL1771665 ZINC71341252 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636308 Cn1ccc(n1)-c1cc(Nc2ccc(cc2)N2CCOCC2)ncc1F InChI=1S/C19H20FN5O/c1-24-7-6-18(23-24)16-12-19(21-13-17(16)20)22-14-2-4-15(5-3-14)25-8-10-26-11-9-25/h2-7,12-13H,8-11H2,1H3,(H,21,22) KLCIVXUAMVFAFQ-UHFFFAOYSA-N 50342489 5-fluoro-4-(1-methyl-1H-pyrazol-3-yl)-N-(4-morpholinophenyl)pyridin-2-amine::CHEMBL1771666 Mitogen-activated protein kinase 10 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342489&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581624 131345425 CHEMBL1771666 ZINC71341566 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636309 Cc1nc(C)n(n1)-c1ccc(Nc2cc(-c3ccn(C)n3)c(F)cn2)cc1 InChI=1S/C19H18FN7/c1-12-22-13(2)27(24-12)15-6-4-14(5-7-15)23-19-10-16(17(20)11-21-19)18-8-9-26(3)25-18/h4-11H,1-3H3,(H,21,23) LGVWSMJDTZVKAT-UHFFFAOYSA-N 50342490 CHEMBL1771667::N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenyl)-5-fluoro-4-(1-methyl-1H-pyrazol-3-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 340 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342490&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54582618 131345426 CHEMBL1771667 ZINC71335303 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636310 Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2cc(-c3ccn(C)n3)c(F)cn2)cc1 InChI=1S/C23H19FN8/c1-15-3-4-16(12-25-15)23-27-14-32(30-23)18-7-5-17(6-8-18)28-22-11-19(20(24)13-26-22)21-9-10-31(2)29-21/h3-14H,1-2H3,(H,26,28) ITHXOKRVXGUDCT-UHFFFAOYSA-N 50342491 5-fluoro-4-(1-methyl-1H-pyrazol-3-yl)-N-(4-(3-(6-methylpyridin-3-yl)-1H-1,2,4-triazol-1-yl)phenyl)pyridin-2-amine::CHEMBL1771668 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342491&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586476 131345427 CHEMBL1771668 ZINC71405026 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636311 Cn1ccc(n1)-c1cc(Nc2ccc(cc2)-n2cnc(n2)-c2ccccn2)ncc1F InChI=1S/C22H17FN8/c1-30-11-9-19(28-30)17-12-21(25-13-18(17)23)27-15-5-7-16(8-6-15)31-14-26-22(29-31)20-4-2-3-10-24-20/h2-14H,1H3,(H,25,27) JLGCIZFVMDDGCK-UHFFFAOYSA-N 50342492 5-fluoro-4-(1-methyl-1H-pyrazol-3-yl)-N-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)phenyl)pyridin-2-amine::CHEMBL1771669 Mitogen-activated protein kinase 10 Homo sapiens 480 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342492&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586477 131345428 CHEMBL1771669 ZINC71341946 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636312 Cn1ccc(n1)-c1cc(Nc2ccc(cc2)-n2cnc(n2)N2CCOCC2)ncc1F InChI=1S/C21H21FN8O/c1-28-7-6-19(26-28)17-12-20(23-13-18(17)22)25-15-2-4-16(5-3-15)30-14-24-21(27-30)29-8-10-31-11-9-29/h2-7,12-14H,8-11H2,1H3,(H,23,25) RNBRCKJRSHVXHY-UHFFFAOYSA-N 50342493 5-fluoro-4-(1-methyl-1H-pyrazol-3-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyridin-2-amine::CHEMBL1771709 Mitogen-activated protein kinase 10 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342493&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54580619 131345429 CHEMBL1771709 ZINC71340429 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636313 Cc1cnc(Nc2ccc(cc2)-n2cnc(n2)N2CCOCC2)cc1-c1ccn(C)n1 InChI=1S/C22H24N8O/c1-16-14-23-21(13-19(16)20-7-8-28(2)26-20)25-17-3-5-18(6-4-17)30-15-24-22(27-30)29-9-11-31-12-10-29/h3-8,13-15H,9-12H2,1-2H3,(H,23,25) NTULJUQCBZIAGY-UHFFFAOYSA-N 50342494 5-methyl-4-(1-methyl-1H-pyrazol-3-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyridin-2-amine::CHEMBL1771710 Mitogen-activated protein kinase 10 Homo sapiens 750 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342494&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587510 131345430 CHEMBL1771710 ZINC71334414 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636314 Fc1cnc(Nc2ccc(cc2)N2CCOCC2)cc1-c1ccn(Cc2ccccc2)n1 InChI=1S/C25H24FN5O/c26-23-17-27-25(28-20-6-8-21(9-7-20)30-12-14-32-15-13-30)16-22(23)24-10-11-31(29-24)18-19-4-2-1-3-5-19/h1-11,16-17H,12-15,18H2,(H,27,28) BTLMRIGOLIXLEA-UHFFFAOYSA-N 50342495 4-(1-benzyl-1H-pyrazol-3-yl)-5-fluoro-N-(4-morpholinophenyl)pyridin-2-amine::CHEMBL1771711 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342495&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585507 131345431 CHEMBL1771711 ZINC71410438 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636315 Fc1cnc(Nc2ccc(cc2)N2CCOCC2)cc1-c1ccn(CCc2ccccc2)n1 InChI=1S/C26H26FN5O/c27-24-19-28-26(29-21-6-8-22(9-7-21)31-14-16-33-17-15-31)18-23(24)25-11-13-32(30-25)12-10-20-4-2-1-3-5-20/h1-9,11,13,18-19H,10,12,14-17H2,(H,28,29) MGVQRBJGTRIHNV-UHFFFAOYSA-N 50342496 5-fluoro-N-(4-morpholinophenyl)-4-(1-phenethyl-1H-pyrazol-3-yl)pyridin-2-amine::CHEMBL1771712 Mitogen-activated protein kinase 10 Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342496&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586479 131345432 CHEMBL1771712 ZINC71331602 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636316 Fc1cnc(Nc2ccc(cc2)N2CCOCC2)cc1-c1ccn(CCN2CCOCC2)n1 InChI=1S/C24H29FN6O2/c25-22-18-26-24(27-19-1-3-20(4-2-19)30-11-15-33-16-12-30)17-21(22)23-5-6-31(28-23)8-7-29-9-13-32-14-10-29/h1-6,17-18H,7-16H2,(H,26,27) UBNXPHMKPZJLOX-UHFFFAOYSA-N 50342497 5-fluoro-4-(1-(2-morpholinoethyl)-1H-pyrazol-3-yl)-N-(4-morpholinophenyl)pyridin-2-amine::CHEMBL1771713 Mitogen-activated protein kinase 10 Homo sapiens 320 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342497&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583576 131345433 CHEMBL1771713 ZINC71341966 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636317 COc1cccc(c1)-n1ccc(n1)-c1ccnc(Nc2ccc(cc2)-n2nc(C)nc2C)c1 InChI=1S/C25H23N7O/c1-17-27-18(2)32(29-17)21-9-7-20(8-10-21)28-25-15-19(11-13-26-25)24-12-14-31(30-24)22-5-4-6-23(16-22)33-3/h4-16H,1-3H3,(H,26,28) IGCSWFJXUUSPJF-UHFFFAOYSA-N 50342498 CHEMBL1771714::N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1-(3-methoxyphenyl)-1H-pyrazol-3-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 650 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342498&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584594 131345434 CHEMBL1771714 ZINC71332229 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636318 Cc1nc(C)n(n1)-c1ccc(Nc2cc(ccn2)-c2ccn(n2)-c2cccc(c2)C#N)cc1 InChI=1S/C25H20N8/c1-17-28-18(2)33(30-17)22-8-6-21(7-9-22)29-25-15-20(10-12-27-25)24-11-13-32(31-24)23-5-3-4-19(14-23)16-26/h3-15H,1-2H3,(H,27,29) JDLPDCWBWOWIGX-UHFFFAOYSA-N 50342499 3-(3-(2-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenylamino)pyridin-4-yl)-1H-pyrazol-1-yl)benzonitrile::CHEMBL1771715 Mitogen-activated protein kinase 10 Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342499&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54582645 131345435 CHEMBL1771715 ZINC71420781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636319 CSc1ccc(cc1)-n1ccc(n1)-c1ccnc(Nc2ccc(cc2)-n2nc(C)nc2C)c1 InChI=1S/C25H23N7S/c1-17-27-18(2)32(29-17)22-6-4-20(5-7-22)28-25-16-19(12-14-26-25)24-13-15-31(30-24)21-8-10-23(33-3)11-9-21/h4-16H,1-3H3,(H,26,28) OYWJSRVUSYOOCP-UHFFFAOYSA-N 50342500 CHEMBL1771716::N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1-(4-(methylthio)phenyl)-1H-pyrazol-3-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 1330 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342500&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581656 131345436 CHEMBL1771716 ZINC71331017 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636320 Cc1nc(C)n(n1)-c1ccc(Nc2cc(ccn2)-c2ccn(n2)-c2ccccn2)cc1 InChI=1S/C23H20N8/c1-16-26-17(2)31(28-16)20-8-6-19(7-9-20)27-22-15-18(10-13-24-22)21-11-14-30(29-21)23-5-3-4-12-25-23/h3-15H,1-2H3,(H,24,27) LWJDVAGCFGXIRL-UHFFFAOYSA-N 50342501 CHEMBL1771717::N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1-(pyridin-2-yl)-1H-pyrazol-3-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 340 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342501&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584595 131345437 CHEMBL1771717 ZINC71410537 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636321 Cc1nc(C)n(n1)-c1ccc(Nc2cc(ccn2)-c2nn(C)cc2-c2ccc(F)cc2)cc1 InChI=1S/C25H22FN7/c1-16-28-17(2)33(30-16)22-10-8-21(9-11-22)29-24-14-19(12-13-27-24)25-23(15-32(3)31-25)18-4-6-20(26)7-5-18/h4-15H,1-3H3,(H,27,29) XAFHGAZOSWMCJO-UHFFFAOYSA-N 50342502 CHEMBL1771718::N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(4-(4-fluorophenyl)-1-methyl-1H-pyrazol-3-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342502&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54580647 131345438 CHEMBL1771718 ZINC71340740 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636322 Cc1nc(C)n(n1)-c1ccc(Nc2cc(ccn2)-c2nn(C)cc2-c2cccnc2)cc1 InChI=1S/C24H22N8/c1-16-27-17(2)32(29-16)21-8-6-20(7-9-21)28-23-13-18(10-12-26-23)24-22(15-31(3)30-24)19-5-4-11-25-14-19/h4-15H,1-3H3,(H,26,28) YJGITIRYIUMDSV-UHFFFAOYSA-N 50342503 CHEMBL1771719::N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1-methyl-4-(pyridin-3-yl)-1H-pyrazol-3-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342503&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584596 131345439 CHEMBL1771719 ZINC71342058 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636323 Cn1cc(-c2ncco2)c(n1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C22H22N6O2/c1-27-15-19(22-24-8-11-30-22)21(26-27)16-6-7-23-20(14-16)25-17-2-4-18(5-3-17)28-9-12-29-13-10-28/h2-8,11,14-15H,9-10,12-13H2,1H3,(H,23,25) FGGCFGLSCSQSEA-UHFFFAOYSA-N 50342504 4-(1-methyl-4-(oxazol-2-yl)-1H-pyrazol-3-yl)-N-(4-morpholinophenyl)pyridin-2-amine::CHEMBL1771720 Mitogen-activated protein kinase 10 Homo sapiens 150 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342504&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587542 131345440 CHEMBL1771720 ZINC71334512 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636324 Cn1cc(cn1)-c1cn(C)nc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C23H25N7O/c1-28-15-18(14-25-28)21-16-29(2)27-23(21)17-7-8-24-22(13-17)26-19-3-5-20(6-4-19)30-9-11-31-12-10-30/h3-8,13-16H,9-12H2,1-2H3,(H,24,26) SYAAJXCWEGGAFG-UHFFFAOYSA-N 50342505 4-(1,1'-dimethyl-1H,1'H-4,4'-bipyrazol-3-yl)-N-(4-morpholinophenyl)pyridin-2-amine::CHEMBL1771721 Mitogen-activated protein kinase 10 Homo sapiens 390 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342505&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586508 131345441 CHEMBL1771721 ZINC71420873 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636325 Cn1cc(-c2ccnn2C)c(n1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C23H25N7O/c1-28-16-20(21-8-10-25-29(21)2)23(27-28)17-7-9-24-22(15-17)26-18-3-5-19(6-4-18)30-11-13-31-14-12-30/h3-10,15-16H,11-14H2,1-2H3,(H,24,26) UWYMHVSONLYJBX-UHFFFAOYSA-N 50342506 4-(1',2-dimethyl-1'H,2H-3,4'-bipyrazol-3'-yl)-N-(4-morpholinophenyl)pyridin-2-amine::CHEMBL1771722 Mitogen-activated protein kinase 10 Homo sapiens 390 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342506&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583602 131345442 CHEMBL1771722 ZINC71341955 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636326 CCCc1cn(C)nc1-c1ccnc(Nc2ccc(cc2)-n2nc(C)nc2C)c1 InChI=1S/C22H25N7/c1-5-6-18-14-28(4)27-22(18)17-11-12-23-21(13-17)25-19-7-9-20(10-8-19)29-16(3)24-15(2)26-29/h7-14H,5-6H2,1-4H3,(H,23,25) LPVMAESUPSOGDY-UHFFFAOYSA-N 50342507 CHEMBL1771723::N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1-methyl-4-propyl-1H-pyrazol-3-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342507&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583603 131345443 CHEMBL1771723 ZINC71340771 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50636327 Cc1cn(C)nc1-c1ccnc(Nc2ccc(cc2)-n2nc(C)nc2C)c1 InChI=1S/C20H21N7/c1-13-12-26(4)25-20(13)16-9-10-21-19(11-16)23-17-5-7-18(8-6-17)27-15(3)22-14(2)24-27/h5-12H,1-4H3,(H,21,23) VRFLASTXVGXXTO-UHFFFAOYSA-N 50342508 CHEMBL1771724::N-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(1,4-dimethyl-1H-pyrazol-3-yl)pyridin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2010.11.104 10.7270/Q2WM1DQN 21185177 Noel, R; Shin, Y; Song, X; He, Y; Koenig, M; Chen, W; Ling, YY; Lin, L; Ruiz, CH; LoGrasso, P; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50342508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50342508&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584597 131345444 CHEMBL1771724 ZINC71335349 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50633741 Cn1c2nc(NC3CCOCC3)ncc2cc(Oc2ccc(F)cc2F)c1=O InChI=1S/C19H18F2N4O3/c1-25-17-11(10-22-19(24-17)23-13-4-6-27-7-5-13)8-16(18(25)26)28-15-3-2-12(20)9-14(15)21/h2-3,8-10,13H,4-7H2,1H3,(H,22,23,24) KKKRKRMVJRHDMG-UHFFFAOYSA-N 50341342 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL1230122 Mitogen-activated protein kinase 10 Homo sapiens 3 ChEMBL 10.1021/jm101423y 10.7270/Q20P109X 21375264 Goldstein, DM; Soth, M; Gabriel, T; Dewdney, N; Kuglstatter, A; Arzeno, H; Chen, J; Bingenheimer, W; Dalrymple, SA; Dunn, J; Farrell, R; Frauchiger, S; La Fargue, J; Ghate, M; Graves, B; Hill, RJ; Li, F; Litman, R; Loe, B; McIntosh, J; McWeeney, D; Papp, E; Park, J; Reese, HF; Roberts, RT; Rotstein, D; San Pablo, B; Sarma, K; Stahl, M; Sung, ML; Suttman, RT; Sjogren, EB; Tan, Y; Trejo, A; Welch, M; Weller, P; Wong, BR; Zecic, H Roche Palo Alto LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341342&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3FN 3FLN 11406590 131344278 CHEMBL1230122 ZINC58633224 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50646342 Cc1ccc(cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O)C(=O)NCCO InChI=1S/C21H18ClF2N3O4/c1-12-2-3-13(19(29)25-6-7-28)8-17(12)27-11-26-20(18(22)21(27)30)31-10-14-4-5-15(23)9-16(14)24/h2-5,8-9,11,28H,6-7,10H2,1H3,(H,25,29) XIPYKUQAZQIESI-UHFFFAOYSA-N 50346918 CHEMBL1738710 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.05.006 10.7270/Q2G73F2S 21620699 Devadas, B; Selness, SR; Xing, L; Madsen, HM; Marrufo, LD; Shieh, H; Messing, DM; Yang, JZ; Morgan, HM; Anderson, GD; Webb, EG; Zhang, J; Devraj, RV; Monahan, JB Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50346918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50346918&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 29A 3ROC 11683817 136353604 CHEMBL1738710 C04080 ZINC38240313 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631495 Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1 InChI=1S/C24H23N9O/c1-31-15-19(14-27-31)17-2-3-18-13-25-23(29-22(18)12-17)28-20-4-6-21(7-5-20)33-16-26-24(30-33)32-8-10-34-11-9-32/h2-7,12-16H,8-11H2,1H3,(H,25,28,29) HGQHCYUSXPTRID-UHFFFAOYSA-N 50340599 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761554 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340599&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 51346941 131343535 CHEMBL1761554 ZINC71330854 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631496 C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2cn[nH]c2)cc1 InChI=1S/C23H21N9O/c1-2-17-12-24-22(29-21(17)11-16(1)18-13-26-27-14-18)28-19-3-5-20(6-4-19)32-15-25-23(30-32)31-7-9-33-10-8-31/h1-6,11-15H,7-10H2,(H,26,27)(H,24,28,29) GMOGCDFLNRXOJV-UHFFFAOYSA-N 50340600 CHEMBL1761555::N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-7-(1H-pyrazol-4-yl)quinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340600&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581287 131343536 CHEMBL1761555 ZINC71330095 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631497 C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2cnoc2)cc1 InChI=1S/C23H20N8O2/c1-2-17-12-24-22(28-21(17)11-16(1)18-13-26-33-14-18)27-19-3-5-20(6-4-19)31-15-25-23(29-31)30-7-9-32-10-8-30/h1-6,11-15H,7-10H2,(H,24,27,28) IZXKZRFEKYIOCQ-UHFFFAOYSA-N 50340601 7-(isoxazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761556 Mitogen-activated protein kinase 10 Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340601&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581288 131343537 CHEMBL1761556 ZINC71316337 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631498 C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)N2CCOCC2)cc1 InChI=1S/C24H26N8O2/c1-4-21(30-7-11-33-12-8-30)15-22-18(1)16-25-23(28-22)27-19-2-5-20(6-3-19)32-17-26-24(29-32)31-9-13-34-14-10-31/h1-6,15-17H,7-14H2,(H,25,27,28) WBZKMLDAAVSVJN-UHFFFAOYSA-N 50340602 7-morpholino-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761557 Mitogen-activated protein kinase 10 Homo sapiens 4400 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340602&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581289 131343538 CHEMBL1761557 ZINC71318993 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631499 C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2cccnc2)cc1 InChI=1S/C25H22N8O/c1-2-19(15-26-9-1)18-3-4-20-16-27-24(30-23(20)14-18)29-21-5-7-22(8-6-21)33-17-28-25(31-33)32-10-12-34-13-11-32/h1-9,14-17H,10-13H2,(H,27,29,30) VXMIYKLZMPPINV-UHFFFAOYSA-N 50340603 CHEMBL1761558::N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-7-(pyridin-3-yl)quinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340603&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581290 131343539 CHEMBL1761558 ZINC71317358 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631500 Cc1ccc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1 InChI=1S/C26H24N8O/c1-18-2-3-20(15-27-18)19-4-5-21-16-28-25(31-24(21)14-19)30-22-6-8-23(9-7-22)34-17-29-26(32-34)33-10-12-35-13-11-33/h2-9,14-17H,10-13H2,1H3,(H,28,30,31) ADWCAKSAEQUTHQ-UHFFFAOYSA-N 50340604 7-(6-methylpyridin-3-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761559 Mitogen-activated protein kinase 10 Homo sapiens 730 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340604&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587174 131343540 CHEMBL1761559 ZINC71329675 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631501 C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2ccccc2)cc1 InChI=1S/C26H23N7O/c1-2-4-19(5-3-1)20-6-7-21-17-27-25(30-24(21)16-20)29-22-8-10-23(11-9-22)33-18-28-26(31-33)32-12-14-34-15-13-32/h1-11,16-18H,12-15H2,(H,27,29,30) OSPBYCRFIGNZMV-UHFFFAOYSA-N 50340605 CHEMBL1761560::N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-7-phenylquinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340605&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587175 131343541 CHEMBL1761560 ZINC71316306 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631502 Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2ncc3ccc(cc3n2)-c2cn[nH]c2)cc1 InChI=1S/C25H19N9/c1-16-2-3-19(12-26-16)24-28-15-34(33-24)22-8-6-21(7-9-22)31-25-27-11-18-5-4-17(10-23(18)32-25)20-13-29-30-14-20/h2-15H,1H3,(H,29,30)(H,27,31,32) BMZLRKZLCCIVNX-UHFFFAOYSA-N 50340606 CHEMBL1761561::N-(4-(3-(6-methylpyridin-3-yl)-1H-1,2,4-triazol-1-yl)phenyl)-7-(1H-pyrazol-4-yl)quinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340606&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587176 131343542 CHEMBL1761561 ZINC71316053 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631503 Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)-c3ccccn3)nc2c1 InChI=1S/C25H19N9/c1-33-15-19(14-29-33)17-5-6-18-13-27-25(31-23(18)12-17)30-20-7-9-21(10-8-20)34-16-28-24(32-34)22-4-2-3-11-26-22/h2-16H,1H3,(H,27,30,31) XQHYPIHJXWTXPZ-UHFFFAOYSA-N 50340607 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761562 Mitogen-activated protein kinase 10 Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340607&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587177 131343543 CHEMBL1761562 ZINC71318946 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631504 Cc1ccc(cn1)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12 InChI=1S/C26H24N8O/c1-18-5-6-19(15-27-18)23-4-2-3-20-16-28-25(31-24(20)23)30-21-7-9-22(10-8-21)34-17-29-26(32-34)33-11-13-35-14-12-33/h2-10,15-17H,11-14H2,1H3,(H,28,30,31) YLCVJWYVKHOSRE-UHFFFAOYSA-N 50340608 8-(6-methylpyridin-3-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761563 Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340608&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585212 131343544 CHEMBL1761563 ZINC71316408 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631505 Cn1cc(cn1)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12 InChI=1S/C24H23N9O/c1-31-15-18(14-27-31)21-4-2-3-17-13-25-23(29-22(17)21)28-19-5-7-20(8-6-19)33-16-26-24(30-33)32-9-11-34-12-10-32/h2-8,13-16H,9-12H2,1H3,(H,25,28,29) MMCVYWQYORICCQ-UHFFFAOYSA-N 50340609 8-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761564 Mitogen-activated protein kinase 10 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340609&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587178 131343545 CHEMBL1761564 ZINC71388861 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631506 COc1ccc(cc1F)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12 InChI=1S/C27H24FN7O2/c1-36-24-10-5-18(15-23(24)28)22-4-2-3-19-16-29-26(32-25(19)22)31-20-6-8-21(9-7-20)35-17-30-27(33-35)34-11-13-37-14-12-34/h2-10,15-17H,11-14H2,1H3,(H,29,31,32) OOOZOACKEXWXQJ-UHFFFAOYSA-N 50340610 8-(3-fluoro-4-methoxyphenyl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761565 Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340610&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584242 131343546 CHEMBL1761565 ZINC71318146 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631507 C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3cccc(-c4nccs4)c3n2)cc1 InChI=1S/C23H20N8OS/c1-2-16-14-25-22(28-20(16)19(3-1)21-24-8-13-33-21)27-17-4-6-18(7-5-17)31-15-26-23(29-31)30-9-11-32-12-10-30/h1-8,13-15H,9-12H2,(H,25,27,28) RQUGSKZRACGFFU-UHFFFAOYSA-N 50340611 CHEMBL1761566::N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-8-(thiazol-2-yl)quinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340611&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581291 131343547 CHEMBL1761566 ZINC71316008 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631508 C1CN(CCO1)c1ncn(n1)-c1ccc(Nc2ncc3cccc(-c4ccccc4)c3n2)cc1 InChI=1S/C26H23N7O/c1-2-5-19(6-3-1)23-8-4-7-20-17-27-25(30-24(20)23)29-21-9-11-22(12-10-21)33-18-28-26(31-33)32-13-15-34-16-14-32/h1-12,17-18H,13-16H2,(H,27,29,30) BILUVSXSPJVCMC-UHFFFAOYSA-N 50340612 CHEMBL1761567::N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-8-phenylquinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340612&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584243 131343548 CHEMBL1761567 ZINC71316295 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631509 COc1ccc(cc1F)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(C)n3)nc12 InChI=1S/C24H19FN6O/c1-15-27-14-31(30-15)19-9-7-18(8-10-19)28-24-26-13-17-4-3-5-20(23(17)29-24)16-6-11-22(32-2)21(25)12-16/h3-14H,1-2H3,(H,26,28,29) NCUDSKLYBDQTIW-UHFFFAOYSA-N 50340613 8-(3-fluoro-4-methoxyphenyl)-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761568 Mitogen-activated protein kinase 10 Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340613&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54584244 131343549 CHEMBL1761568 ZINC71330846 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631510 Cc1ncn(n1)-c1ccc(Nc2ncc3cccc(-c4nccs4)c3n2)cc1 InChI=1S/C20H15N7S/c1-13-23-12-27(26-13)16-7-5-15(6-8-16)24-20-22-11-14-3-2-4-17(18(14)25-20)19-21-9-10-28-19/h2-12H,1H3,(H,22,24,25) BMPQHQFIJBXIOA-UHFFFAOYSA-N 50340614 CHEMBL1761569::N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(thiazol-2-yl)quinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340614&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583278 131343550 CHEMBL1761569 ZINC71315925 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631511 COc1ccc(cc1F)-c1cccc2cnc(Nc3ccc(cc3)-n3cnc(n3)-c3ccccn3)nc12 InChI=1S/C28H20FN7O/c1-37-25-13-8-18(15-23(25)29)22-6-4-5-19-16-31-28(34-26(19)22)33-20-9-11-21(12-10-20)36-17-32-27(35-36)24-7-2-3-14-30-24/h2-17H,1H3,(H,31,33,34) PXUXFHCHDUJREO-UHFFFAOYSA-N 50340615 8-(3-fluoro-4-methoxyphenyl)-N-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761570 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340615&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583279 131343551 CHEMBL1761570 ZINC71296468 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631512 Cc1ncn(n1)-c1ccc(Nc2ncc3cccc(-c4ccc(C)nc4)c3n2)cc1 InChI=1S/C23H19N7/c1-15-6-7-17(12-24-15)21-5-3-4-18-13-25-23(28-22(18)21)27-19-8-10-20(11-9-19)30-14-26-16(2)29-30/h3-14H,1-2H3,(H,25,27,28) GUEKGHGNEKDOMS-UHFFFAOYSA-N 50340616 CHEMBL1761571::N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-8-(6-methylpyridin-3-yl)quinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340616&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583280 131343552 CHEMBL1761571 ZINC71316724 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631513 Cc1ccc(cn1)-c1cccc2cnc(Nc3ccc4OCOc4c3)nc12 InChI=1S/C21H16N4O2/c1-13-5-6-14(10-22-13)17-4-2-3-15-11-23-21(25-20(15)17)24-16-7-8-18-19(9-16)27-12-26-18/h2-11H,12H2,1H3,(H,23,24,25) FUDMBWNGRHHUHL-UHFFFAOYSA-N 50340617 CHEMBL1761572::N-(benzo[d][1,3]dioxol-5-yl)-8-(6-methylpyridin-3-yl)quinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340617&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583281 131343553 CHEMBL1761572 ZINC71317325 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631514 Cc1ccc(cn1)-c1cccc2cnc(Nc3ccc(F)cc3)nc12 InChI=1S/C20H15FN4/c1-13-5-6-14(11-22-13)18-4-2-3-15-12-23-20(25-19(15)18)24-17-9-7-16(21)8-10-17/h2-12H,1H3,(H,23,24,25) CVTJYTULQRZSLP-UHFFFAOYSA-N 50340618 CHEMBL1761573::N-(4-fluorophenyl)-8-(6-methylpyridin-3-yl)quinazolin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340618&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586163 131343554 CHEMBL1761573 ZINC71316046 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631515 Cc1ccc(cn1)-c1cccc2cnc(Nc3ccc(cc3)C(=O)N3CCOCC3)nc12 InChI=1S/C25H23N5O2/c1-17-5-6-19(15-26-17)22-4-2-3-20-16-27-25(29-23(20)22)28-21-9-7-18(8-10-21)24(31)30-11-13-32-14-12-30/h2-10,15-16H,11-14H2,1H3,(H,27,28,29) ZDRGZZRLUUCRMU-UHFFFAOYSA-N 50340619 (4-(8-(6-methylpyridin-3-yl)quinazolin-2-ylamino)phenyl)(morpholino)methanone::CHEMBL1761574 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340619&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54585213 131343555 CHEMBL1761574 ZINC71296965 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631516 Cc1ccc(cn1)-c1cccc2cnc(NC3CCC(O)CC3)nc12 InChI=1S/C20H22N4O/c1-13-5-6-14(11-21-13)18-4-2-3-15-12-22-20(24-19(15)18)23-16-7-9-17(25)10-8-16/h2-6,11-12,16-17,25H,7-10H2,1H3,(H,22,23,24) GGSIOFMZSJTMMB-UHFFFAOYSA-N 50340620 4-(8-(6-methylpyridin-3-yl)quinazolin-2-ylamino)cyclohexanol::CHEMBL1761575 Mitogen-activated protein kinase 10 Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340620&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54583282 131343556 CHEMBL1761575 ZINC71296485 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631517 Cc1ccc(cn1)-c1cccc2cnc(N[C@H]3CC[C@H](CC3)C(=O)N3CCCC3)nc12 InChI=1S/C25H29N5O/c1-17-7-8-19(15-26-17)22-6-4-5-20-16-27-25(29-23(20)22)28-21-11-9-18(10-12-21)24(31)30-13-2-3-14-30/h4-8,15-16,18,21H,2-3,9-14H2,1H3,(H,27,28,29)/t18-,21+ YYDXTCLVCUQGMO-RVWIWJKTSA-N 50340621 ((cis)-4-(8-(6-methylpyridin-3-yl)quinazolin-2-ylamino)cyclohexyl)(pyrrolidin-1-yl)methanone::CHEMBL1761576 Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340621&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54587179 131343557 CHEMBL1761576 ZINC71318127 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631518 Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1Cl InChI=1S/C24H22ClN9O/c1-32-14-17(13-28-32)20-7-2-16-12-26-23(30-22(16)21(20)25)29-18-3-5-19(6-4-18)34-15-27-24(31-34)33-8-10-35-11-9-33/h2-7,12-15H,8-11H2,1H3,(H,26,29,30) GIIITGYQMLZQJE-UHFFFAOYSA-N 50340622 8-chloro-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761577 Mitogen-activated protein kinase 10 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340622&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 51346940 131343558 CHEMBL1761577 ZINC71296967 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631519 CC(C)n1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1Cl InChI=1S/C26H26ClN9O/c1-17(2)35-15-19(14-30-35)22-8-3-18-13-28-25(32-24(18)23(22)27)31-20-4-6-21(7-5-20)36-16-29-26(33-36)34-9-11-37-12-10-34/h3-8,13-17H,9-12H2,1-2H3,(H,28,31,32) PYFMPAWBPVAOQN-UHFFFAOYSA-N 50340623 8-chloro-7-(1-isopropyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761578 Mitogen-activated protein kinase 10 Homo sapiens 63 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340623&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54582304 131343559 CHEMBL1761578 ZINC71319368 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631520 Cc1c(ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12)-c1cnn(C)c1 InChI=1S/C25H25N9O/c1-17-22(19-14-28-32(2)15-19)8-3-18-13-26-24(30-23(17)18)29-20-4-6-21(7-5-20)34-16-27-25(31-34)33-9-11-35-12-10-33/h3-8,13-16H,9-12H2,1-2H3,(H,26,29,30) LYOQNNXXHVGLRC-UHFFFAOYSA-N 50340624 8-methyl-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761579 Mitogen-activated protein kinase 10 Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340624&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54580285 131343560 CHEMBL1761579 ZINC71317086 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631521 Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1C(F)(F)F InChI=1S/C25H22F3N9O/c1-35-14-17(13-31-35)20-7-2-16-12-29-23(33-22(16)21(20)25(26,27)28)32-18-3-5-19(6-4-18)37-15-30-24(34-37)36-8-10-38-11-9-36/h2-7,12-15H,8-11H2,1H3,(H,29,32,33) POQRXQWWFZULIY-UHFFFAOYSA-N 50340625 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-8-(trifluoromethyl)quinazolin-2-amine::CHEMBL1761580 Mitogen-activated protein kinase 10 Homo sapiens 190 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340625&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586164 131343561 CHEMBL1761580 ZINC71329161 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631522 Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1C1CC1 InChI=1S/C27H27N9O/c1-34-16-20(15-30-34)23-9-4-19-14-28-26(32-25(19)24(23)18-2-3-18)31-21-5-7-22(8-6-21)36-17-29-27(33-36)35-10-12-37-13-11-35/h4-9,14-18H,2-3,10-13H2,1H3,(H,28,31,32) SVIZILSXAQTEQC-UHFFFAOYSA-N 50340626 8-cyclopropyl-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761581 Mitogen-activated protein kinase 10 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54582305 131343562 CHEMBL1761581 ZINC71329240 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631523 Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1-c1cnn(C)c1 InChI=1S/C28H27N11O/c1-36-16-20(14-31-36)24-8-3-19-13-29-27(34-26(19)25(24)21-15-32-37(2)17-21)33-22-4-6-23(7-5-22)39-18-30-28(35-39)38-9-11-40-12-10-38/h3-8,13-18H,9-12H2,1-2H3,(H,29,33,34) YSXBDGQITSROHI-UHFFFAOYSA-N 50340627 7,8-bis(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761582 Mitogen-activated protein kinase 10 Homo sapiens 9 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54581292 131343563 CHEMBL1761582 ZINC71329237 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631524 Cn1cc(cn1)-c1ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc2c1-c1ccccc1 InChI=1S/C30H27N9O/c1-37-19-23(18-33-37)26-12-7-22-17-31-29(35-28(22)27(26)21-5-3-2-4-6-21)34-24-8-10-25(11-9-24)39-20-32-30(36-39)38-13-15-40-16-14-38/h2-12,17-20H,13-16H2,1H3,(H,31,34,35) CEANXNAMUUCBQK-UHFFFAOYSA-N 50340628 7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)-8-phenylquinazolin-2-amine::CHEMBL1761583 Mitogen-activated protein kinase 10 Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340628&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54582306 131343564 CHEMBL1761583 ZINC71315872 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50631525 COc1c(ccc2cnc(Nc3ccc(cc3)-n3cnc(n3)N3CCOCC3)nc12)-c1cnn(C)c1 InChI=1S/C25H25N9O2/c1-32-15-18(14-28-32)21-8-3-17-13-26-24(30-22(17)23(21)35-2)29-19-4-6-20(7-5-19)34-16-27-25(31-34)33-9-11-36-12-10-33/h3-8,13-16H,9-12H2,1-2H3,(H,26,29,30) XNLNCNYXYAAOEA-UHFFFAOYSA-N 50340629 8-methoxy-7-(1-methyl-1H-pyrazol-4-yl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)quinazolin-2-amine::CHEMBL1761584 Mitogen-activated protein kinase 10 Homo sapiens 4 ChEMBL 10.1016/j.bmcl.2011.01.079 10.7270/Q2F1901V 21316221 He, Y; Kamenecka, TM; Shin, Y; Song, X; Jiang, R; Noel, R; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Khan, S; Koenig, M; LoGrasso, PV The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340629&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54582307 131343565 CHEMBL1761584 ZINC71317059 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50640700 C[C@H](CS(C)(=O)=O)Nc1ncc2cc(Oc3ccc(F)cc3F)c(=O)n(C)c2n1 InChI=1S/C18H18F2N4O4S/c1-10(9-29(3,26)27)22-18-21-8-11-6-15(17(25)24(2)16(11)23-18)28-14-5-4-12(19)7-13(14)20/h4-8,10H,9H2,1-3H3,(H,21,22,23)/t10-/m1/s1 DVEYHFXOGUYFBU-SNVBAGLBSA-N 50341346 (R)-6-(2,4-difluorophenoxy)-8-methyl-2-(1-(methylsulfonyl)propan-2-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one::6-(2,4-Difluorophenoxy)-2-((R)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one::6-(2,4-difluorophenoxy)-8-methyl-2-{[(1R)-1-methyl-2-(methylsulfonyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one::CHEMBL1232769 Mitogen-activated protein kinase 10 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2011.03.098 10.7270/Q26H4HR7 21515047 Soth, M; Abbot, S; Abubakari, A; Arora, N; Arzeno, H; Billedeau, R; Dewdney, N; Durkin, K; Frauchiger, S; Ghate, M; Goldstein, DM; Hill, RJ; Kuglstatter, A; Li, F; Loe, B; McCaleb, K; McIntosh, J; Papp, E; Park, J; Stahl, M; Sung, ML; Suttman, R; Swinney, DC; Weller, P; Wong, B; Zecic, H; Gabriel, T Roche Palo Alto http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341346&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search FLS 3FLS 44517630 131344282 CHEMBL1232769 ZINC58633497 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50639526 NS(=O)(=O)N1CCC(CC1)Nc1nccc(n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1 InChI=1S/C19H26N6O5S2/c20-32(28,29)25-9-6-16(7-10-25)22-19-21-8-5-18(23-19)15-1-3-17(4-2-15)31(26,27)24-11-13-30-14-12-24/h1-5,8,16H,6-7,9-14H2,(H2,20,28,29)(H,21,22,23) OMXIAXJGEYOQEC-UHFFFAOYSA-N 50343673 4-(4-(4-(morpholinosulfonyl)phenyl)pyrimidin-2-ylamino)piperidine-1-sulfonamide::CHEMBL1773329 Mitogen-activated protein kinase 10 Homo sapiens 880 ChEMBL 10.1016/j.bmcl.2011.03.044 10.7270/Q22V2GDS 21489792 Kim, S; Jung, JK; Lee, HS; Kim, Y; Kim, J; Choi, K; Baek, DJ; Moon, B; Oh, KS; Lee, BH; Shin, KJ; Pae, AN; Nam, G; Roh, EJ; Cho, YS; Choo, H Korea Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343673&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54586040 131346609 CHEMBL1773329 ZINC71296218 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50639527 O=S(=O)(N1CCNCC1)c1ccc(cc1)-c1ccnc(NC2CCNCC2)n1 InChI=1S/C19H26N6O2S/c26-28(27,25-13-11-21-12-14-25)17-3-1-15(2-4-17)18-7-10-22-19(24-18)23-16-5-8-20-9-6-16/h1-4,7,10,16,20-21H,5-6,8-9,11-14H2,(H,22,23,24) IXMFEZPRVSMTLE-UHFFFAOYSA-N 50343674 4-(4-(piperazin-1-ylsulfonyl)phenyl)-N-(piperidin-4-yl)pyrimidin-2-amine::CHEMBL1773334 Mitogen-activated protein kinase 10 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2011.03.044 10.7270/Q22V2GDS 21489792 Kim, S; Jung, JK; Lee, HS; Kim, Y; Kim, J; Choi, K; Baek, DJ; Moon, B; Oh, KS; Lee, BH; Shin, KJ; Pae, AN; Nam, G; Roh, EJ; Cho, YS; Choo, H Korea Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50343674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50343674&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54582175 131346610 CHEMBL1773334 ZINC71317198 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50668074 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50669567 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50668204 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50665689 CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31) QADPYRIHXKWUSV-UHFFFAOYSA-N 50355393 BGJ398::CHEMBL1834657::US9434697, BGJ398::US9730931, BGJ398 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm2006222 10.7270/Q22N52N1 21936542 Guagnano, V; Furet, P; Spanka, C; Bordas, V; Le Douget, M; Stamm, C; Brueggen, J; Jensen, MR; Schnell, C; Schmid, H; Wartmann, M; Berghausen, J; Drueckes, P; Zimmerlin, A; Bussiere, D; Murray, J; Graus Porta, D Novartis Institute for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355393&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 07J 3TT0 53235510 136362079 CHEMBL1834657 ZINC72105034 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50667222 COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29) SHPFDGWALWEPGS-UHFFFAOYSA-N 50355494 CHEMBL1908396 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355494&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9869779 136959518 CHEMBL1908396 ZINC13975055 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50666029 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Mitogen-activated protein kinase 10 Homo sapiens 1100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50667284 Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1 BPNUQXPIQBZCMR-IBGZPJMESA-N 15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search SS3 2UZT 11314340 46515449 DB08568 5655 ZINC16052569 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659435 Fc1ccc(CC(=O)Nc2scc(Br)c2-c2nnc[nH]2)c2ccncc12 InChI=1S/C17H11BrFN5OS/c18-12-7-26-17(15(12)16-21-8-22-24-16)23-14(25)5-9-1-2-13(19)11-6-20-4-3-10(9)11/h1-4,6-8H,5H2,(H,23,25)(H,21,22,24) OOXCRLOLUWLQCN-UHFFFAOYSA-N 50352601 CHEMBL1822132 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352601&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56682209 136359287 CHEMBL1822132 ZINC72181506 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659436 Fc1cnc2cccc(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c2c1 InChI=1S/C17H11BrFN5OS/c18-12-7-26-17(15(12)16-21-8-22-24-16)23-14(25)4-9-2-1-3-13-11(9)5-10(19)6-20-13/h1-3,5-8H,4H2,(H,23,25)(H,21,22,24) HDGJMVJJOYGVSR-UHFFFAOYSA-N 50352602 CHEMBL1822133 Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352602&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56665245 136359288 CHEMBL1822133 ZINC72181377 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659437 Fc1cc(CC(=O)Nc2scc(Br)c2-c2nnc[nH]2)c2cccnc2c1 InChI=1S/C17H11BrFN5OS/c18-12-7-26-17(15(12)16-21-8-22-24-16)23-14(25)5-9-4-10(19)6-13-11(9)2-1-3-20-13/h1-4,6-8H,5H2,(H,23,25)(H,21,22,24) NJZPPBSOOUXHEF-UHFFFAOYSA-N 50352603 CHEMBL1822134 Mitogen-activated protein kinase 10 Homo sapiens 41 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352603&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56661802 136359289 CHEMBL1822134 ZINC72179059 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659438 FC(F)(F)c1cnc2cccc(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c2c1 InChI=1S/C18H11BrF3N5OS/c19-12-7-29-17(15(12)16-24-8-25-27-16)26-14(28)4-9-2-1-3-13-11(9)5-10(6-23-13)18(20,21)22/h1-3,5-8H,4H2,(H,26,28)(H,24,25,27) FXBNFLKLXHFULB-UHFFFAOYSA-N 50352604 CHEMBL1822135 Mitogen-activated protein kinase 10 Homo sapiens 52 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352604&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56678888 136359290 CHEMBL1822135 ZINC72179060 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659439 FC(F)(F)c1cc(CC(=O)Nc2scc(Br)c2-c2nnc[nH]2)c2cccnc2c1 InChI=1S/C18H11BrF3N5OS/c19-12-7-29-17(15(12)16-24-8-25-27-16)26-14(28)5-9-4-10(18(20,21)22)6-13-11(9)2-1-3-23-13/h1-4,6-8H,5H2,(H,26,28)(H,24,25,27) ZYPRSWQPKLBUQM-UHFFFAOYSA-N 50352605 CHEMBL1822136::US9796706, Compound 95 Mitogen-activated protein kinase 10 Homo sapiens 280 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352605&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56658303 136359291 CHEMBL1822136 ZINC72142847 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659440 FC(F)(F)c1ccc(CC(=O)Nc2scc(Cl)c2-c2nnc[nH]2)c2cccnc12 InChI=1S/C18H11ClF3N5OS/c19-12-7-29-17(14(12)16-24-8-25-27-16)26-13(28)6-9-3-4-11(18(20,21)22)15-10(9)2-1-5-23-15/h1-5,7-8H,6H2,(H,26,28)(H,24,25,27) RLMPNZZDUJOQQE-UHFFFAOYSA-N 50352606 CHEMBL1822137 Mitogen-activated protein kinase 10 Homo sapiens 183 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352606&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869290 136359292 CHEMBL1822137 ZINC72179065 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659441 Brc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1nnc[nH]1 InChI=1S/C17H14BrN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22) JCKBTQZTGPJTII-UHFFFAOYSA-N 50338291 CHEMBL1682013::N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide Mitogen-activated protein kinase 10 Homo sapiens 28 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338291&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869882 125088393 CHEMBL1682013 ZINC66167134 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659442 Brc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1nnc[nH]1 InChI=1S/C16H13BrN6O2S/c17-9-7-26-16(14(9)15-19-8-20-22-15)21-12(24)6-23-11-2-1-5-18-10(11)3-4-13(23)25/h1-2,5,7-8H,3-4,6H2,(H,21,24)(H,19,20,22) JIQMILPCZGXYEY-UHFFFAOYSA-N 50352607 CHEMBL1822138 Mitogen-activated protein kinase 10 Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352607&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56661803 136359293 CHEMBL1822138 ZINC72179071 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659443 O=C(CN1C(=O)CCc2ncccc12)Nc1scc(C#N)c1-c1nnc[nH]1 InChI=1S/C17H13N7O2S/c18-6-10-8-27-17(15(10)16-20-9-21-23-16)22-13(25)7-24-12-2-1-5-19-11(12)3-4-14(24)26/h1-2,5,8-9H,3-4,7H2,(H,22,25)(H,20,21,23) ZZGXJNUHZVCAOW-UHFFFAOYSA-N 50352608 CHEMBL1822139 Mitogen-activated protein kinase 10 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352608&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869285 136359294 CHEMBL1822139 ZINC72179072 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659444 Brc1csc(NC(=O)Cn2c3ccncc3ccc2=O)c1-c1nnc[nH]1 InChI=1S/C16H11BrN6O2S/c17-10-7-26-16(14(10)15-19-8-20-22-15)21-12(24)6-23-11-3-4-18-5-9(11)1-2-13(23)25/h1-5,7-8H,6H2,(H,21,24)(H,19,20,22) UJLHONOXXNLUDV-UHFFFAOYSA-N 50352609 CHEMBL1822140 Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352609&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56668696 136359295 CHEMBL1822140 ZINC72180253 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659445 FC(F)(F)c1cc2n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c(=O)ccc2cn1 InChI=1S/C17H10BrF3N6O2S/c18-9-6-30-16(14(9)15-23-7-24-26-15)25-12(28)5-27-10-3-11(17(19,20)21)22-4-8(10)1-2-13(27)29/h1-4,6-7H,5H2,(H,25,28)(H,23,24,26) YSSREBGNECUESU-UHFFFAOYSA-N 50352610 CHEMBL1822141 Mitogen-activated protein kinase 10 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352610&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56665246 136359296 CHEMBL1822141 ZINC72180156 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659446 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c(=O)ccc2n1 InChI=1S/C17H10BrF3N6O2S/c18-8-6-30-16(14(8)15-22-7-23-26-15)25-12(28)5-27-10-2-3-11(17(19,20)21)24-9(10)1-4-13(27)29/h1-4,6-7H,5H2,(H,25,28)(H,22,23,26) UCRSZQFDYBPHLJ-UHFFFAOYSA-N 50352611 CHEMBL1822142 Mitogen-activated protein kinase 10 Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352611&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869491 136359297 CHEMBL1822142 ZINC72180157 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659447 Brc1csc(NC(=O)Cn2c3ccnn3ccc2=O)c1-c1nnc[nH]1 InChI=1S/C14H10BrN7O2S/c15-8-6-25-14(12(8)13-16-7-17-20-13)19-9(23)5-21-10-1-3-18-22(10)4-2-11(21)24/h1-4,6-7H,5H2,(H,19,23)(H,16,17,20) LMZRJJTWTQNOEI-UHFFFAOYSA-N 50352612 CHEMBL1822143 Mitogen-activated protein kinase 10 Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352612&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56658304 136359298 CHEMBL1822143 ZINC72180158 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659448 FC(F)(F)c1cc2n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c(=O)ccn2n1 InChI=1S/C15H9BrF3N7O2S/c16-7-5-29-14(12(7)13-20-6-21-23-13)22-9(27)4-25-10-3-8(15(17,18)19)24-26(10)2-1-11(25)28/h1-3,5-6H,4H2,(H,22,27)(H,20,21,23) SYSMFXCWULAWTA-UHFFFAOYSA-N 50352613 CHEMBL1822144 Mitogen-activated protein kinase 10 Homo sapiens 14 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352613&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869493 136359299 CHEMBL1822144 ZINC72179910 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659449 Fc1cc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c2cc1F InChI=1S/C17H10BrF2N5O2S/c18-9-6-28-17(15(9)16-21-7-22-24-16)23-13(26)5-25-12-4-11(20)10(19)3-8(12)1-2-14(25)27/h1-4,6-7H,5H2,(H,23,26)(H,21,22,24) TXUPRVNNKMSBLZ-UHFFFAOYSA-N 50352614 CHEMBL1822145 Mitogen-activated protein kinase 10 Homo sapiens 5 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352614&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868925 136359300 CHEMBL1822145 ZINC72179911 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659450 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c(=O)ccc2c1 InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-2-10(18(20,21)22)5-9(12)1-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) CRWXJGJNJZPMRW-UHFFFAOYSA-N 50352615 CHEMBL1822146 Mitogen-activated protein kinase 10 Homo sapiens 9 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352615&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868926 136359301 CHEMBL1822146 ZINC72181755 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659451 FC(F)(F)c1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c2c1 InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-5-10(18(20,21)22)3-1-9(12)2-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) UBEKWKCSOKGROP-UHFFFAOYSA-N 50352616 CHEMBL1822147 Mitogen-activated protein kinase 10 Homo sapiens 9 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352616&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869881 136359302 CHEMBL1822147 ZINC72179347 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659452 FC(F)(F)c1cccc2n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c(=O)ccc12 InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-1-2-10(18(20,21)22)9(12)4-5-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) PHDVAWAUKMHEJM-UHFFFAOYSA-N 50352617 CHEMBL1822148 Mitogen-activated protein kinase 10 Homo sapiens 71 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352617&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56672173 136359303 CHEMBL1822148 ZINC72142787 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659453 FC(F)(F)Oc1ccc2n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c(=O)ccc2c1 InChI=1S/C18H11BrF3N5O3S/c19-11-7-31-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-2-10(30-18(20,21)22)5-9(12)1-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) BZKOXELLQJFKSQ-UHFFFAOYSA-N 50352618 CHEMBL1822149 Mitogen-activated protein kinase 10 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352618&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56665247 136359304 CHEMBL1822149 ZINC72179348 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659454 FC(F)(F)Oc1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3nnc[nH]3)c2c1 InChI=1S/C18H11BrF3N5O3S/c19-11-7-31-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-5-10(30-18(20,21)22)3-1-9(12)2-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) VFFOCQZCDTURBY-UHFFFAOYSA-N 50352619 CHEMBL1822150 Mitogen-activated protein kinase 10 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352619&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56668697 136359305 CHEMBL1822150 ZINC72179285 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659455 Brc1csc(NC(=O)Cn2c3ccc(cc3ccc2=O)C#N)c1-c1nnc[nH]1 InChI=1S/C18H11BrN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-3-1-10(6-20)5-11(13)2-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24) KBJSPAOJLUYMQM-UHFFFAOYSA-N 50352620 CHEMBL1822151 Mitogen-activated protein kinase 10 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352620&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56682210 136359306 CHEMBL1822151 ZINC72179286 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659456 Brc1csc(NC(=O)Cn2c3cc(ccc3ccc2=O)C#N)c1-c1nnc[nH]1 InChI=1S/C18H11BrN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-5-10(6-20)1-2-11(13)3-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24) NKUVBRQPLJOWBI-UHFFFAOYSA-N 50352621 CHEMBL1822152 Mitogen-activated protein kinase 10 Homo sapiens 2 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352621&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56672174 136359307 CHEMBL1822152 ZINC72179287 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659457 Brc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1ncco1 InChI=1S/C17H13BrN4O3S/c18-10-9-26-17(15(10)16-20-6-7-25-16)21-13(23)8-22-12-2-1-5-19-11(12)3-4-14(22)24/h1-2,5-7,9H,3-4,8H2,(H,21,23) AEIKXFACENTHCD-UHFFFAOYSA-N 50352622 CHEMBL1822153::US9796706, Compound 149 Mitogen-activated protein kinase 10 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352622&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56672175 136359308 CHEMBL1822153 ZINC72179292 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659458 Brc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1nccs1 InChI=1S/C17H13BrN4O2S2/c18-10-9-26-17(15(10)16-20-6-7-25-16)21-13(23)8-22-12-2-1-5-19-11(12)3-4-14(22)24/h1-2,5-7,9H,3-4,8H2,(H,21,23) IUGSVSMCSCKMLY-UHFFFAOYSA-N 50352623 CHEMBL1822154::US9796706, Compound 150 Mitogen-activated protein kinase 10 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352623&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56668539 136359309 CHEMBL1822154 ZINC72181085 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659459 Cn1cnc(n1)-c1c(Br)csc1NC(=O)CN1C(=O)CCc2ncccc12 InChI=1S/C17H15BrN6O2S/c1-23-9-20-16(22-23)15-10(18)8-27-17(15)21-13(25)7-24-12-3-2-6-19-11(12)4-5-14(24)26/h2-3,6,8-9H,4-5,7H2,1H3,(H,21,25) RDFFZPKZBXFQEF-UHFFFAOYSA-N 50352624 CHEMBL1822305::US9796706, Compound 139 Mitogen-activated protein kinase 10 Homo sapiens 3 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352624&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56665092 136359310 CHEMBL1822305 ZINC72181730 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659460 O=C(CN1C(=O)CCc2ncccc12)Nc1scc(C#N)c1-c1nccs1 InChI=1S/C18H13N5O2S2/c19-8-11-10-27-18(16(11)17-21-6-7-26-17)22-14(24)9-23-13-2-1-5-20-12(13)3-4-15(23)25/h1-2,5-7,10H,3-4,9H2,(H,22,24) HWQRBIQRGAZWGS-UHFFFAOYSA-N 50352625 CHEMBL1822306::US9796706, Compound 146 Mitogen-activated protein kinase 10 Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352625&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56658171 136359311 CHEMBL1822306 ZINC72181608 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659461 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1 InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) ZLFCYABKBKXJOL-UHFFFAOYSA-N 50352626 CHEMBL1822307::US9796706, Compound 131 Mitogen-activated protein kinase 10 Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56675421 136359312 CHEMBL1822307 ZINC72181609 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659462 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3nccs3)c(=O)ccc2c1 InChI=1S/C20H11F3N4O2S2/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) ACDQVXJNZDLXFP-UHFFFAOYSA-N 50352627 CHEMBL1822308::US9796706, Compound 134 Mitogen-activated protein kinase 10 Homo sapiens 9 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869490 136359313 CHEMBL1822308 ZINC72181610 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50659463 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3cscn3)c(=O)ccc2c1 InChI=1S/C20H11F3N4O2S2/c21-20(22,23)13-2-3-15-11(5-13)1-4-17(29)27(15)7-16(28)26-19-18(12(6-24)8-31-19)14-9-30-10-25-14/h1-5,8-10H,7H2,(H,26,28) IRABIGXKJCMNIG-UHFFFAOYSA-N 50352628 CHEMBL1822309::US9796706, Compound 136 Mitogen-activated protein kinase 10 Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2011.06.100 10.7270/Q29Z959K 21813278 Bowers, S; Truong, AP; Jeffrey Neitz, R; Hom, RK; Sealy, JM; Probst, GD; Quincy, D; Peterson, B; Chan, W; Galemmo, RA; Konradi, AW; Sham, HL; Toth, G; Pan, H; Lin, M; Yao, N; Artis, DR; Zhang, H; Chen, L; Dryer, M; Samant, B; Zmolek, W; Wong, K; Lorentzen, C; Goldbach, E; Tonn, G; Quinn, KP; Sauer, JM; Wright, S; Powell, K; Ruslim, L; Ren, Z; Bard, F; Yednock, TA; Griswold-Prenner, I Elan Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352628&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56665093 136359314 CHEMBL1822309 ZINC72181483 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50667656 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50667946 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Mitogen-activated protein kinase 10 Homo sapiens 4300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50680988 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50683823 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Mitogen-activated protein kinase 10 Homo sapiens 4300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50686603 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50670926 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50671028 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50674086 COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) UBPYILGKFZZVDX-UHFFFAOYSA-N 4552 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4552&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search DB8 6OP9,5AJQ,4MXO,4MXY,4MXX,4MXZ,3SOA,5VC3,6FDY,5I9X,3UE4,4QMN,5VCY 5328940 8034215 39112 CHEMBL288441 DB06616 5710 ZINC22448983 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50689871 C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 WCWUXEGQKLTGDX-LLVKDONJSA-N 50184807 (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol::(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol::BMS-540215::CHEMBL377300 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184807&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11234052 104069124 CHEMBL377300 5671 ZINC13684256 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50669779 COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) QQWUGDVOUVUTOY-UHFFFAOYSA-N 482158 BDBM50242742::TAE684 Mitogen-activated protein kinase 10 Homo sapiens 67 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=482158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=482158&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16038120 443551321 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50674204 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Mitogen-activated protein kinase 10 Homo sapiens 3600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50685467 Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1 InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) UJIAQDJKSXQLIT-UHFFFAOYSA-N 25084 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25084&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B6J 5WNK 10427712 56374226 5715 ZINC06718666 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50686952 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50671320 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Mitogen-activated protein kinase 10 Homo sapiens 1900 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50678649 C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 50306682 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search VGH 2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ 11626560 104161043 64310 CHEMBL601719 DB08700 4903 ZINC35902489 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50681389 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50681431 Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 24654 4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24654&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 56269605 5662 ZINC16052857 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50684269 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Mitogen-activated protein kinase 10 Homo sapiens 5500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50685561 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50688678 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50674401 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50682977 CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ JWNPDZNEKVCWMY-VQHVLOKHSA-N 50161957 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib Mitogen-activated protein kinase 10 Homo sapiens 2500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161957&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9915743 104048227 CHEMBL180022 5686 ZINC03916214 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50685666 Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) GFMMXOIFOQCCGU-UHFFFAOYSA-N 50132260 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide::2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide::CHEMBL105442::CI-1040::PD-18435::PD-184352::US8575391, 341 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132260&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 6918454 104023279 CHEMBL105442 5676 ZINC01489691 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50690236 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50677384 Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) CYOHGALHFOKKQC-UHFFFAOYSA-N 50355497 AZD-6244::CHEMBL1614701 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355497&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3EW 4U7Z,7JUZ,7JUT,7M0T 10127622 136959521 CHEMBL1614701 ZINC31773258 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50670106 CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1 InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) LHNIIDJUOCFXAP-UHFFFAOYSA-N 25028 4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine::GDC-0941::GDC0941::US10112932, pictilisib::US10851091, Compound pictilisib Mitogen-activated protein kinase 10 Homo sapiens 560 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25028&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search GD9 3DBS,2Y3A,2WXP 17755052 56374172 65326 ZINC16052714 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50671637 Cc1cnc2c(NCCN)nc3ccc(C)cc3n12 InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18) PSPFQEBFYXJZEV-UHFFFAOYSA-N 25919 BMS-345541::BMS345541::CHEMBL471496::N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25919&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9813758 56413207 CHEMBL471496 5669 ZINC13285379 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50673106 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Mitogen-activated protein kinase 10 Homo sapiens 2800 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50674524 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 OYONTEXKYJZFHA-SSHUPFPWSA-N 50242737 (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242737&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10461815 104099202 CHEMBL450786 5700 ZINC03938668 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50687395 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50674649 CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 25013 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25013&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search G93 3D0E,5U94 16725726 56374157 5196 ZINC34285211 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50691965 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 10 Homo sapiens 35 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50670414 CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12 InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19) MFAQYJIYDMLAIM-UHFFFAOYSA-N 36409 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242::CID24905147::US10172858, Table 2.1::US9828378, # 1 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36409&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search P2X 4JT5 24905147 117643995 ZINC36056301 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50674766 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Mitogen-activated protein kinase 10 Homo sapiens 3200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50680479 CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib Mitogen-activated protein kinase 10 Homo sapiens 2000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 0WM 4G5J 10184653 104144352 61390 CHEMBL1173655 DB08916 5667 ZINC03976838 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50683562 COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) NHHQJBCNYHBUSI-UHFFFAOYSA-N 60665 BDBM50249542::US9145414, R406::US9212178, R406 Mitogen-activated protein kinase 10 Homo sapiens 37 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60665&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 585 3PIY,3FQS 11213558 316921779 DB07159 ZINC13555629 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50672024 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50673575 COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 XXJWYDDUDKYVKI-UHFFFAOYSA-N 50331096 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline::CHEMBL491473::Cediranib::US10464902, Cediranib::ZD-2171 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331096&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9933475 123110211 CHEMBL491473 DB04849 5664 ZINC03948085 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50673671 Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1 InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 BCZUAADEACICHN-UHFFFAOYSA-N 60589 6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (4)::BDBM50355498 Mitogen-activated protein kinase 10 Homo sapiens 1900 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60589&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search SX8 3DKF,3DKG 16187854 24782328 DB08584 ZINC15962404 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50691010 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Mitogen-activated protein kinase 10 Homo sapiens 4300 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50692284 O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1 InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ YYLKKYCXAOBSRM-JXMROGBWSA-N 50355496 CHEMBL1908397 Mitogen-activated protein kinase 10 Homo sapiens 51 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355496&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11427553 136959520 CHEMBL1908397 ZINC43201999 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50688165 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50688199 Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39) AXRCEOKUDYDWLF-UHFFFAOYSA-N 50128285 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL300138 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128285&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 176167 104020050 CHEMBL300138 5693 ZINC01494900 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50691090 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Mitogen-activated protein kinase 10 Homo sapiens 760 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50678113 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50693876 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50692521 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50692764 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50692799 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Mitogen-activated protein kinase 10 Homo sapiens 5500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50694218 COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1 InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42) SEJGTFPOEJWEGG-UHFFFAOYSA-N 50355504 CHEMBL1908393 Mitogen-activated protein kinase 10 Homo sapiens 3900 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355504&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57399640 136959528 CHEMBL1908393 ZINC73140828 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50703203 [O-][n+]1ccc2c(ccnc2c1-c1c(Cl)cccc1Cl)-c1ccc(F)cc1Cl InChI=1S/C20H10Cl3FN2O/c21-15-2-1-3-16(22)18(15)20-19-14(7-9-26(20)27)12(6-8-25-19)13-5-4-11(24)10-17(13)23/h1-10H AUZOBOALIFKXNA-UHFFFAOYSA-N 50357884 CHEMBL1916359 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm200975u 10.7270/Q2MW2HKR 21999461 Lumeras, W; Vidal, L; Vidal, B; Balague, C; Orellana, A; Maldonado, M; Dominguez, M; Segarra, V; Caturla, F Rhône-Poulenc Rorer http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50357884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50357884&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24896769 136961908 CHEMBL1916359 ZINC73162320 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704569 COc1ccc(Oc2ncc(Cl)c(Nc3ccccc3C(N)=O)n2)cc1 InChI=1S/C18H15ClN4O3/c1-25-11-6-8-12(9-7-11)26-18-21-10-14(19)17(23-18)22-15-5-3-2-4-13(15)16(20)24/h2-10H,1H3,(H2,20,24)(H,21,22,23) DEPFXQSAHGKYPV-UHFFFAOYSA-N 50358497 CHEMBL1923217 Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358497&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54764593 136962521 CHEMBL1923217 ZINC73168970 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704570 COc1ccc(Oc2cc(Nc3ccccc3-c3nnc[nH]3)c(Cl)cn2)cc1 InChI=1S/C20H16ClN5O2/c1-27-13-6-8-14(9-7-13)28-19-10-18(16(21)11-22-19)25-17-5-3-2-4-15(17)20-23-12-24-26-20/h2-12H,1H3,(H,22,25)(H,23,24,26) VHYFUPDFEUQXIH-UHFFFAOYSA-N 50358498 CHEMBL1923216 Mitogen-activated protein kinase 10 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358498&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57397862 136962522 CHEMBL1923216 ZINC73162782 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704571 CNC(=O)c1ccccc1Nc1cc(Oc2ccc(OC)cc2)ncc1Cl InChI=1S/C20H18ClN3O3/c1-22-20(25)15-5-3-4-6-17(15)24-18-11-19(23-12-16(18)21)27-14-9-7-13(26-2)8-10-14/h3-12H,1-2H3,(H,22,25)(H,23,24) PBOODVLUBNPLLU-UHFFFAOYSA-N 50358499 CHEMBL1923215 Mitogen-activated protein kinase 10 Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358499&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57397861 136962523 CHEMBL1923215 ZINC73162779 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704572 COc1ccc(Oc2cc(Nc3c(Cl)cccc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C20H15ClF3N3O3/c1-29-11-5-7-12(8-6-11)30-17-9-16(14(10-26-17)20(22,23)24)27-18-13(19(25)28)3-2-4-15(18)21/h2-10H,1H3,(H2,25,28)(H,26,27) IREYXIHHOFTWLZ-UHFFFAOYSA-N 50358500 CHEMBL1923213 Mitogen-activated protein kinase 10 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358500&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57390771 136962524 CHEMBL1923213 ZINC73386585 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704573 COc1ccc(Oc2cc(Nc3c(F)cccc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C20H15F4N3O3/c1-29-11-5-7-12(8-6-11)30-17-9-16(14(10-26-17)20(22,23)24)27-18-13(19(25)28)3-2-4-15(18)21/h2-10H,1H3,(H2,25,28)(H,26,27) NAOPVTWAXICEKG-UHFFFAOYSA-N 50358501 CHEMBL1923212 Mitogen-activated protein kinase 10 Homo sapiens 60 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358501&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57397860 136962525 CHEMBL1923212 ZINC73166624 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704574 COc1ccc(Oc2cc(Nc3cc(OC)ccc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C21H18F3N3O4/c1-29-12-3-5-13(6-4-12)31-19-10-18(16(11-26-19)21(22,23)24)27-17-9-14(30-2)7-8-15(17)20(25)28/h3-11H,1-2H3,(H2,25,28)(H,26,27) VLAOHGRMNLKXML-UHFFFAOYSA-N 50358502 CHEMBL1923211 Mitogen-activated protein kinase 10 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358502&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57390770 136962526 CHEMBL1923211 ZINC73162774 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704575 COc1ccc(Oc2cc(Nc3cc(Cl)ccc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C20H15ClF3N3O3/c1-29-12-3-5-13(6-4-12)30-18-9-17(15(10-26-18)20(22,23)24)27-16-8-11(21)2-7-14(16)19(25)28/h2-10H,1H3,(H2,25,28)(H,26,27) UNYBVPZZEAKQRB-UHFFFAOYSA-N 50358503 CHEMBL1923210 Mitogen-activated protein kinase 10 Homo sapiens 78 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358503&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57392583 136962527 CHEMBL1923210 ZINC73161959 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704576 COc1ccc(Oc2cc(Nc3cc(F)ccc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C20H15F4N3O3/c1-29-12-3-5-13(6-4-12)30-18-9-17(15(10-26-18)20(22,23)24)27-16-8-11(21)2-7-14(16)19(25)28/h2-10H,1H3,(H2,25,28)(H,26,27) LRYJDPKREAPZHH-UHFFFAOYSA-N 50358504 CHEMBL1923209 Mitogen-activated protein kinase 10 Homo sapiens 49 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358504&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57397859 136962528 CHEMBL1923209 ZINC73161957 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704577 COc1ccc(Oc2cc(Nc3ccc(Cl)cc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C20H15ClF3N3O3/c1-29-12-3-5-13(6-4-12)30-18-9-17(15(10-26-18)20(22,23)24)27-16-7-2-11(21)8-14(16)19(25)28/h2-10H,1H3,(H2,25,28)(H,26,27) LGXVWUOKYGJIHS-UHFFFAOYSA-N 50358505 CHEMBL1923208 Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358505&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57403029 136962529 CHEMBL1923208 ZINC73161953 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704578 COc1ccc(Oc2cc(Nc3ccc(F)cc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C20H15F4N3O3/c1-29-12-3-5-13(6-4-12)30-18-9-17(15(10-26-18)20(22,23)24)27-16-7-2-11(21)8-14(16)19(25)28/h2-10H,1H3,(H2,25,28)(H,26,27) PNWZXNYVZYYYBP-UHFFFAOYSA-N 50358506 CHEMBL1923207 Mitogen-activated protein kinase 10 Homo sapiens 45 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358506&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57401275 136962530 CHEMBL1923207 ZINC73160737 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704579 COc1ccc(Oc2cc(Nc3cccc(OC)c3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C21H18F3N3O4/c1-29-12-6-8-13(9-7-12)31-18-10-16(14(11-26-18)21(22,23)24)27-15-4-3-5-17(30-2)19(15)20(25)28/h3-11H,1-2H3,(H2,25,28)(H,26,27) OHQKKBIYGPOIJR-UHFFFAOYSA-N 50358507 CHEMBL1923206 Mitogen-activated protein kinase 10 Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358507&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57403028 136962531 CHEMBL1923206 ZINC73163046 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704580 COc1ccc(Oc2cc(Nc3cccc(Cl)c3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C20H15ClF3N3O3/c1-29-11-5-7-12(8-6-11)30-17-9-16(13(10-26-17)20(22,23)24)27-15-4-2-3-14(21)18(15)19(25)28/h2-10H,1H3,(H2,25,28)(H,26,27) BAZVBENMFYJAQU-UHFFFAOYSA-N 50358508 CHEMBL1923205 Mitogen-activated protein kinase 10 Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358508&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57397858 136962532 CHEMBL1923205 ZINC73163044 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704581 NC(=O)c1ccccc1Nc1cc(Oc2ccc(cc2)-c2cccnc2)ncc1C(F)(F)F InChI=1S/C24H17F3N4O2/c25-24(26,27)19-14-30-22(12-21(19)31-20-6-2-1-5-18(20)23(28)32)33-17-9-7-15(8-10-17)16-4-3-11-29-13-16/h1-14H,(H2,28,32)(H,30,31) STRBDWNAMGZLQF-UHFFFAOYSA-N 50358509 CHEMBL1923204 Mitogen-activated protein kinase 10 Homo sapiens 72 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358509&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57390769 136962533 CHEMBL1923204 ZINC73169901 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704582 NC(=O)c1ccccc1Nc1cc(Oc2ccc(cc2)N2CCNCC2)ncc1C(F)(F)F InChI=1S/C23H22F3N5O2/c24-23(25,26)18-14-29-21(13-20(18)30-19-4-2-1-3-17(19)22(27)32)33-16-7-5-15(6-8-16)31-11-9-28-10-12-31/h1-8,13-14,28H,9-12H2,(H2,27,32)(H,29,30) QSCQLHKHLCTFFF-UHFFFAOYSA-N 50358510 CHEMBL1923203 Mitogen-activated protein kinase 10 Homo sapiens 34 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358510&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57394306 136962534 CHEMBL1923203 ZINC73163962 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704583 NC(=O)c1ccccc1Nc1cc(Oc2ccc(cc2)-n2cncn2)ncc1C(F)(F)F InChI=1S/C21H15F3N6O2/c22-21(23,24)16-10-27-19(9-18(16)29-17-4-2-1-3-15(17)20(25)31)32-14-7-5-13(6-8-14)30-12-26-11-28-30/h1-12H,(H2,25,31)(H,27,29) PQVPHORDWRBWLS-UHFFFAOYSA-N 50358511 CHEMBL1923202 Mitogen-activated protein kinase 10 Homo sapiens 80 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358511&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57403027 136962535 CHEMBL1923202 ZINC73163959 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704584 NC(=O)c1ccccc1Nc1cc(Oc2ccc3OCOc3c2)ncc1C(F)(F)F InChI=1S/C20H14F3N3O4/c21-20(22,23)13-9-25-18(30-11-5-6-16-17(7-11)29-10-28-16)8-15(13)26-14-4-2-1-3-12(14)19(24)27/h1-9H,10H2,(H2,24,27)(H,25,26) ZDJZJCGVCBBGDA-UHFFFAOYSA-N 50358512 CHEMBL1923201 Mitogen-activated protein kinase 10 Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358512&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57399521 136962536 CHEMBL1923201 ZINC73163956 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704585 NC(=O)c1ccccc1Nc1cc(Oc2ccc3ccccc3c2)ncc1C(F)(F)F InChI=1S/C23H16F3N3O2/c24-23(25,26)18-13-28-21(31-16-10-9-14-5-1-2-6-15(14)11-16)12-20(18)29-19-8-4-3-7-17(19)22(27)30/h1-13H,(H2,27,30)(H,28,29) BYRMCDKPXHCUKH-UHFFFAOYSA-N 50358513 CHEMBL1923200 Mitogen-activated protein kinase 10 Homo sapiens 320 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358513&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57392582 136962537 CHEMBL1923200 ZINC73403410 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704586 NC(=O)c1ccccc1Nc1cc(Oc2cccc3ccccc23)ncc1C(F)(F)F InChI=1S/C23H16F3N3O2/c24-23(25,26)17-13-28-21(31-20-11-5-7-14-6-1-2-8-15(14)20)12-19(17)29-18-10-4-3-9-16(18)22(27)30/h1-13H,(H2,27,30)(H,28,29) BBVXPNDIVLNONK-UHFFFAOYSA-N 50358514 CHEMBL1923199 Mitogen-activated protein kinase 10 Homo sapiens 990 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358514&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57403026 136962538 CHEMBL1923199 ZINC73163953 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704587 COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(cn2)C(F)(F)F)c(Cl)c1 InChI=1S/C20H15ClF3N3O3/c1-29-11-6-7-17(14(21)8-11)30-18-9-16(13(10-26-18)20(22,23)24)27-15-5-3-2-4-12(15)19(25)28/h2-10H,1H3,(H2,25,28)(H,26,27) IBSOKDKEFQOSIY-UHFFFAOYSA-N 50358515 CHEMBL1923198 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358515&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57394305 136962539 CHEMBL1923198 ZINC73162578 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704588 NC(=O)c1ccccc1Nc1cc(Oc2ccc(Cl)c(Cl)c2)ncc1C(F)(F)F InChI=1S/C19H12Cl2F3N3O2/c20-13-6-5-10(7-14(13)21)29-17-8-16(12(9-26-17)19(22,23)24)27-15-4-2-1-3-11(15)18(25)28/h1-9H,(H2,25,28)(H,26,27) RXFZUHJHYNKIJF-UHFFFAOYSA-N 50358516 CHEMBL1921815 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358516&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57400156 136962540 CHEMBL1921815 ZINC73169378 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704589 NC(=O)c1ccccc1Nc1cc(Oc2cccc(Cl)c2)ncc1C(F)(F)F InChI=1S/C19H13ClF3N3O2/c20-11-4-3-5-12(8-11)28-17-9-16(14(10-25-17)19(21,22)23)26-15-7-2-1-6-13(15)18(24)27/h1-10H,(H2,24,27)(H,25,26) OCHCLSOFYOZAEG-UHFFFAOYSA-N 50358517 CHEMBL1923197 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358517&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57390768 136962541 CHEMBL1923197 ZINC73169377 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704590 NC(=O)c1ccccc1Nc1cc(Oc2ccc(Br)cc2)ncc1C(F)(F)F InChI=1S/C19H13BrF3N3O2/c20-11-5-7-12(8-6-11)28-17-9-16(14(10-25-17)19(21,22)23)26-15-4-2-1-3-13(15)18(24)27/h1-10H,(H2,24,27)(H,25,26) FHGSYAFPJQQASV-UHFFFAOYSA-N 50358518 CHEMBL1923196 Mitogen-activated protein kinase 10 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358518&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57392581 136962542 CHEMBL1923196 ZINC73169255 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704591 NC(=O)c1ccccc1Nc1cc(Oc2ccc(F)cc2)ncc1C(F)(F)F InChI=1S/C19H13F4N3O2/c20-11-5-7-12(8-6-11)28-17-9-16(14(10-25-17)19(21,22)23)26-15-4-2-1-3-13(15)18(24)27/h1-10H,(H2,24,27)(H,25,26) ORQYRUZYGXLVJP-UHFFFAOYSA-N 50358519 CHEMBL1923195 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358519&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57399520 136962543 CHEMBL1923195 ZINC73169253 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704592 CC(C)(C)Oc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C23H22F3N3O3/c1-22(2,3)32-15-10-8-14(9-11-15)31-20-12-19(17(13-28-20)23(24,25)26)29-18-7-5-4-6-16(18)21(27)30/h4-13H,1-3H3,(H2,27,30)(H,28,29) QZVKYTBQVHAICK-UHFFFAOYSA-N 50358520 CHEMBL1923194 Mitogen-activated protein kinase 10 Homo sapiens 27 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358520&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57399519 136962544 CHEMBL1923194 ZINC73168519 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704593 CCCOc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C22H20F3N3O3/c1-2-11-30-14-7-9-15(10-8-14)31-20-12-19(17(13-27-20)22(23,24)25)28-18-6-4-3-5-16(18)21(26)29/h3-10,12-13H,2,11H2,1H3,(H2,26,29)(H,27,28) LJWSUGUZCIJVRS-UHFFFAOYSA-N 50358521 CHEMBL1923193 Mitogen-activated protein kinase 10 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358521&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57390767 136962545 CHEMBL1923193 ZINC73168517 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704594 CCOc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C21H18F3N3O3/c1-2-29-13-7-9-14(10-8-13)30-19-11-18(16(12-26-19)21(22,23)24)27-17-6-4-3-5-15(17)20(25)28/h3-12H,2H2,1H3,(H2,25,28)(H,26,27) MHEZQXUHNPRCFQ-UHFFFAOYSA-N 50358522 CHEMBL1923192 Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358522&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57396061 136962546 CHEMBL1923192 ZINC73168515 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704595 NC(=O)c1ccccc1Nc1cc(Oc2ccc(OC(F)(F)F)cc2)ncc1C(F)(F)F InChI=1S/C20H13F6N3O3/c21-19(22,23)14-10-28-17(31-11-5-7-12(8-6-11)32-20(24,25)26)9-16(14)29-15-4-2-1-3-13(15)18(27)30/h1-10H,(H2,27,30)(H,28,29) BDLXZJHUOJNXIO-UHFFFAOYSA-N 50358523 CHEMBL1923191 Mitogen-activated protein kinase 10 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358523&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57397857 136962547 CHEMBL1923191 ZINC73167589 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704596 COc1ccccc1Oc1cc(Nc2ccccc2C(N)=O)c(cn1)C(F)(F)F InChI=1S/C20H16F3N3O3/c1-28-16-8-4-5-9-17(16)29-18-10-15(13(11-25-18)20(21,22)23)26-14-7-3-2-6-12(14)19(24)27/h2-11H,1H3,(H2,24,27)(H,25,26) VRPLZCPGZWJMEU-UHFFFAOYSA-N 50358524 CHEMBL1923190 Mitogen-activated protein kinase 10 Homo sapiens 3500 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358524&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57403025 136962548 CHEMBL1923190 ZINC73167587 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704597 COc1cccc(Oc2cc(Nc3ccccc3C(N)=O)c(cn2)C(F)(F)F)c1 InChI=1S/C20H16F3N3O3/c1-28-12-5-4-6-13(9-12)29-18-10-17(15(11-25-18)20(21,22)23)26-16-8-3-2-7-14(16)19(24)27/h2-11H,1H3,(H2,24,27)(H,25,26) CUABCZMVBDQUGO-UHFFFAOYSA-N 50358525 CHEMBL1923189 Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358525&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57403024 136962549 CHEMBL1923189 ZINC73167582 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704598 COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(cn2)C(F)(F)F)cc1 InChI=1S/C20H16F3N3O3/c1-28-12-6-8-13(9-7-12)29-18-10-17(15(11-25-18)20(21,22)23)26-16-5-3-2-4-14(16)19(24)27/h2-11H,1H3,(H2,24,27)(H,25,26) SHQNUFDSTNIIBP-UHFFFAOYSA-N 50358526 CHEMBL1923188 Mitogen-activated protein kinase 10 Homo sapiens 37 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358526&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 54764508 136962550 CHEMBL1923188 ZINC73170209 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704599 COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(Cl)cn2)cc1 InChI=1S/C19H16ClN3O3/c1-25-12-6-8-13(9-7-12)26-18-10-17(15(20)11-22-18)23-16-5-3-2-4-14(16)19(21)24/h2-11H,1H3,(H2,21,24)(H,22,23) GKAVCPBETIUUNC-UHFFFAOYSA-N 50358527 CHEMBL1923187 Mitogen-activated protein kinase 10 Homo sapiens 15 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358527&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57403023 136962551 CHEMBL1923187 ZINC73163341 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704600 COc1ccc(Oc2cc(Nc3ccccc3C(N)=O)c(F)cn2)cc1 InChI=1S/C19H16FN3O3/c1-25-12-6-8-13(9-7-12)26-18-10-17(15(20)11-22-18)23-16-5-3-2-4-14(16)19(21)24/h2-11H,1H3,(H2,21,24)(H,22,23) LRUPHJAQKSRDNC-UHFFFAOYSA-N 50358528 CHEMBL1923186 Mitogen-activated protein kinase 10 Homo sapiens 48 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358528&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57396060 136962552 CHEMBL1923186 ZINC73170208 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704601 NC(=O)c1ccccc1Nc1ccnc(Oc2ccc(cc2)N2CCNCC2)c1 InChI=1S/C22H23N5O2/c23-22(28)19-3-1-2-4-20(19)26-16-9-10-25-21(15-16)29-18-7-5-17(6-8-18)27-13-11-24-12-14-27/h1-10,15,24H,11-14H2,(H2,23,28)(H,25,26) UHNHUQMERWMFSO-UHFFFAOYSA-N 50358529 CHEMBL1923185 Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358529&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57403022 136962553 CHEMBL1923185 ZINC73168737 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50704623 NC(=O)c1ccccc1Nc1ccnc(Oc2ccccc2)c1 InChI=1S/C18H15N3O2/c19-18(22)15-8-4-5-9-16(15)21-13-10-11-20-17(12-13)23-14-6-2-1-3-7-14/h1-12H,(H2,19,22)(H,20,21) FXVBEGJQINEFDZ-UHFFFAOYSA-N 50358530 CHEMBL1923184 Mitogen-activated protein kinase 10 Homo sapiens 520 ChEMBL 10.1016/j.bmcl.2011.09.090 10.7270/Q2V69K0W 22004719 Song, X; Chen, W; Lin, L; Ruiz, CH; Cameron, MD; Duckett, DR; Kamenecka, TM The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358530&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57402972 136962554 CHEMBL1923184 ZINC73158821 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50693121 CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34) GUBJNPWVIUFSTR-UHFFFAOYSA-N 50355499 CHEMBL1908395::CHEMBL1908842 Mitogen-activated protein kinase 10 Homo sapiens 240 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355499&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11676971 136959523 CHEMBL1908842CHEMBL1908395 ZINC38226716 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50694471 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Mitogen-activated protein kinase 10 Homo sapiens 1100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50693180 COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25) ZNOLRTPMNMPLHY-UHFFFAOYSA-N 50309910 CHEMBL608154::ML-120B::N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309910&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9929127 104164271 CHEMBL608154 5694 ZINC06717113 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50693201 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Mitogen-activated protein kinase 10 Homo sapiens 3100 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search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itogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50693227 CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26) VAARYSWULJUGST-UHFFFAOYSA-N 6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6568&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search P17 1M52,5IA3 447077 8036145 49791 CHEMBL386051 DB02567 5699 ZINC02047743 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50694593 CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) HZTYDQRUAWIZRE-UHFFFAOYSA-N 27817 2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25182616 57560329 5683 ZINC43202844 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50697417 Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) HHZIURLSWUIHRB-UHFFFAOYSA-N 50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib Mitogen-activated protein kinase 10 Homo sapiens 2000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search NIL 5MO4,3CS9,3GP0 644241 104056419 52172 CHEMBL255863 DB04868 5697 ZINC06716957 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50696134 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1 InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) WJEOLQLKVOPQFV-UHFFFAOYSA-N 50355495 CHEMBL1908391 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355495&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search G65 7TVX,5MQL,7JU7 10074640 136959519 63450 CHEMBL1908391 ZINC34177219 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50697636 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Mitogen-activated protein kinase 10 Homo sapiens 2500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50706399 CN(C)CCN1CCN(CCC1=O)C(=O)c1cc(sc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C InChI=1S/C25H33Cl2N5O3S/c1-25(2,3)19-15-16(22(36-19)29-24(35)28-18-8-6-7-17(26)21(18)27)23(34)32-10-9-20(33)31(13-14-32)12-11-30(4)5/h6-8,15H,9-14H2,1-5H3,(H2,28,29,35) SIUIQMQVKUUQQF-UHFFFAOYSA-N 50359359 CHEMBL1929238 Mitogen-activated protein kinase 10 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2011.09.078 10.7270/Q2NC61NH 22014550 Moffett, K; Konteatis, Z; Nguyen, D; Shetty, R; Ludington, J; Fujimoto, T; Lee, KJ; Chai, X; Namboodiri, H; Karpusas, M; Dorsey, B; Guarnieri, F; Bukhtiyarova, M; Springman, E; Michelotti, E Ansaris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50359359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50359359&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search P7C 3P7C 53384644 136963383 CHEMBL1929238 ZINC72318122 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50706400 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 10 Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2011.09.078 10.7270/Q2NC61NH 22014550 Moffett, K; Konteatis, Z; Nguyen, D; Shetty, R; Ludington, J; Fujimoto, T; Lee, KJ; Chai, X; Namboodiri, H; Karpusas, M; Dorsey, B; Guarnieri, F; Bukhtiyarova, M; Springman, E; Michelotti, E Ansaris http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50696262 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Mitogen-activated protein kinase 10 Homo sapiens 5900 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50696312 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50696467 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50720090 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1073/pnas.0502000102 10.7270/Q2PC32TB 16249345 Conway, JG; McDonald, B; Parham, J; Keith, B; Rusnak, DW; Shaw, E; Jansen, M; Lin, P; Payne, A; Crosby, RM; Johnson, JH; Frick, L; Lin, MH; Depee, S; Tadepalli, S; Votta, B; James, I; Fuller, K; Chambers, TJ; Kull, FC; Chamberlain, SD; Hutchins, JT GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50720131 CCn1c(nc2cnc(Oc3cccc(NC(=O)c4ccc(OCCN5CCOCC5)cc4)c3)cc12)-c1nonc1N InChI=1S/C29H30N8O5/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38) YOVNFNXUCOWYSG-UHFFFAOYSA-N 14047 Aminofurazanyl-azabenzimidazole 6n::N-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy}phenyl)-4-[2-(morpholin-4-yl)ethoxy]benzamide Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1124/jpet.106.110635 10.7270/Q2DV1KBV 17018693 Doe, C; Bentley, R; Behm, DJ; Lafferty, R; Stavenger, R; Jung, D; Bamford, M; Panchal, T; Grygielko, E; Wright, LL; Smith, GK; Chen, Z; Webb, C; Khandekar, S; Yi, T; Kirkpatrick, R; Dul, E; Jolivette, L; Marino, JP; Willette, R; Lee, D; Hu, E GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14047&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16095342 46514412 ZINC14954335 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50720132 CCn1c(nc2cncc(C(=O)N3CC[C@H](N)C3)c12)-c1nonc1N InChI=1S/C15H18N8O2/c1-2-23-12-9(15(24)22-4-3-8(16)7-22)5-18-6-10(12)19-14(23)11-13(17)21-25-20-11/h5-6,8H,2-4,7,16H2,1H3,(H2,17,21)/t8-/m0/s1 PHWHNHYZZNJPLB-QMMMGPOBSA-N 50365218 CHEMBL1956071::GSK screening, 29 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1124/jpet.106.110635 10.7270/Q2DV1KBV 17018693 Doe, C; Bentley, R; Behm, DJ; Lafferty, R; Stavenger, R; Jung, D; Bamford, M; Panchal, T; Grygielko, E; Wright, LL; Smith, GK; Chen, Z; Webb, C; Khandekar, S; Yi, T; Kirkpatrick, R; Dul, E; Jolivette, L; Marino, JP; Willette, R; Lee, D; Hu, E GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50365218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50365218&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16095343 136969280 CHEMBL1956071 ZINC35076001 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715920 COc1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CCCC4)c3n2)cc1 InChI=1S/C23H24N6O/c1-30-19-13-11-17(12-14-19)25-22-24-15-20-21(28-22)29(18-9-5-6-10-18)23(27-20)26-16-7-3-2-4-8-16/h2-4,7-8,11-15,18H,5-6,9-10H2,1H3,(H,26,27)(H,24,25,28) XROXTBFBPYWNOH-UHFFFAOYSA-N 50363446 CHEMBL1946324 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363446&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57402785 136967508 CHEMBL1946324 ZINC82150457 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715921 COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C4CCCC4)c3n2)cc1 InChI=1S/C23H23FN6O/c1-31-17-12-10-15(11-13-17)26-22-25-14-20-21(29-22)30(16-6-2-3-7-16)23(28-20)27-19-9-5-4-8-18(19)24/h4-5,8-14,16H,2-3,6-7H2,1H3,(H,27,28)(H,25,26,29) IMFVPVKPQOQCBY-UHFFFAOYSA-N 50363447 CHEMBL1946325 Mitogen-activated protein kinase 10 Homo sapiens 210 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363447&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JBI 3TTJ 11647397 136967509 CHEMBL1946325 ZINC35997549 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715922 COc1ccc(Nc2ncc3nc(Nc4ccccc4Cl)n(C4CCCC4)c3n2)cc1 InChI=1S/C23H23ClN6O/c1-31-17-12-10-15(11-13-17)26-22-25-14-20-21(29-22)30(16-6-2-3-7-16)23(28-20)27-19-9-5-4-8-18(19)24/h4-5,8-14,16H,2-3,6-7H2,1H3,(H,27,28)(H,25,26,29) GHNFBAGHBLQXTA-UHFFFAOYSA-N 50363448 CHEMBL1946326 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363448&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24811103 136967510 CHEMBL1946326 ZINC82151666 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715923 COc1ccc(Nc2ncc3nc(Nc4ccc(F)cc4F)n(C4CCCC4)c3n2)cc1 InChI=1S/C23H22F2N6O/c1-32-17-9-7-15(8-10-17)27-22-26-13-20-21(30-22)31(16-4-2-3-5-16)23(29-20)28-19-11-6-14(24)12-18(19)25/h6-13,16H,2-5H2,1H3,(H,28,29)(H,26,27,30) JSGWWFGFBLUWSD-UHFFFAOYSA-N 50363449 CHEMBL1946327 Mitogen-activated protein kinase 10 Homo sapiens 140 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363449&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57390517 136967511 CHEMBL1946327 ZINC73198081 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715924 COc1ccc(Nc2ncc3nc(Nc4c(F)cccc4F)n(C4CCCC4)c3n2)cc1 InChI=1S/C23H22F2N6O/c1-32-16-11-9-14(10-12-16)27-22-26-13-19-21(30-22)31(15-5-2-3-6-15)23(28-19)29-20-17(24)7-4-8-18(20)25/h4,7-13,15H,2-3,5-6H2,1H3,(H,28,29)(H,26,27,30) VQAHFLPDFJAHTG-UHFFFAOYSA-N 50363450 CHEMBL1946328 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363450&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57390518 136967512 CHEMBL1946328 ZINC73198490 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715925 CNc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1 InChI=1S/C17H19FN6/c1-19-16-20-10-14-15(23-16)24(11-6-2-3-7-11)17(22-14)21-13-9-5-4-8-12(13)18/h4-5,8-11H,2-3,6-7H2,1H3,(H,21,22)(H,19,20,23) LYMPHEWUZFSXGM-UHFFFAOYSA-N 50363451 CHEMBL1946329 Mitogen-activated protein kinase 10 Homo sapiens 680 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363451&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24811099 136967513 CHEMBL1946329 ZINC73198491 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715926 CCNc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1 InChI=1S/C18H21FN6/c1-2-20-17-21-11-15-16(24-17)25(12-7-3-4-8-12)18(23-15)22-14-10-6-5-9-13(14)19/h5-6,9-12H,2-4,7-8H2,1H3,(H,22,23)(H,20,21,24) YPXNJMUSTWLKRM-UHFFFAOYSA-N 50363452 CHEMBL1946330 Mitogen-activated protein kinase 10 Homo sapiens 260 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363452&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24811100 136967514 CHEMBL1946330 ZINC73198493 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715927 CC(C)Nc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1 InChI=1S/C19H23FN6/c1-12(2)22-18-21-11-16-17(25-18)26(13-7-3-4-8-13)19(24-16)23-15-10-6-5-9-14(15)20/h5-6,9-13H,3-4,7-8H2,1-2H3,(H,23,24)(H,21,22,25) KEJPODFMUKBEAK-UHFFFAOYSA-N 50363453 CHEMBL1946331 Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363453&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24811101 136967515 CHEMBL1946331 ZINC73197732 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715928 Fc1ccccc1Nc1nc2cnc(NC3CCCCC3)nc2n1C1CCCC1 InChI=1S/C22H27FN6/c23-17-12-6-7-13-18(17)26-22-27-19-14-24-21(25-15-8-2-1-3-9-15)28-20(19)29(22)16-10-4-5-11-16/h6-7,12-16H,1-5,8-11H2,(H,26,27)(H,24,25,28) NGFCRLVABQTLPT-UHFFFAOYSA-N 50363454 CHEMBL1946332 Mitogen-activated protein kinase 10 Homo sapiens 50 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363454&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24811102 136967516 CHEMBL1946332 ZINC82150749 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715929 O[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1 InChI=1S/C22H27FN6O/c23-17-7-3-4-8-18(17)26-22-27-19-13-24-21(25-14-9-11-16(30)12-10-14)28-20(19)29(22)15-5-1-2-6-15/h3-4,7-8,13-16,30H,1-2,5-6,9-12H2,(H,26,27)(H,24,25,28)/t14-,16- YVQKIQSJMFGJEG-KOMQPUFPSA-N 50363455 CHEMBL1946333 Mitogen-activated protein kinase 10 Homo sapiens 12 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363455&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57390519 136967517 CHEMBL1946333 ZINC82151936 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715930 N[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3ccccc3F)n(C3CCCC3)c2n1 InChI=1S/C22H28FN7/c23-17-7-3-4-8-18(17)27-22-28-19-13-25-21(26-15-11-9-14(24)10-12-15)29-20(19)30(22)16-5-1-2-6-16/h3-4,7-8,13-16H,1-2,5-6,9-12,24H2,(H,27,28)(H,25,26,29)/t14-,15- ORAWIJDEGBHDCO-SHTZXODSSA-N 50363456 CHEMBL1946334 Mitogen-activated protein kinase 10 Homo sapiens 31 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363456&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57392289 136967518 CHEMBL1946334 ZINC82151939 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715931 CCn1c(Nc2ccccc2F)nc2cnc(Nc3ccc(OC)cc3)nc12 InChI=1S/C20H19FN6O/c1-3-27-18-17(25-20(27)24-16-7-5-4-6-15(16)21)12-22-19(26-18)23-13-8-10-14(28-2)11-9-13/h4-12H,3H2,1-2H3,(H,24,25)(H,22,23,26) QIQWHUHEIKULHZ-UHFFFAOYSA-N 50363457 CHEMBL1946335 Mitogen-activated protein kinase 10 Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363457&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24810999 136967519 CHEMBL1946335 ZINC82151944 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715932 COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C(C)C)c3n2)cc1 InChI=1S/C21H21FN6O/c1-13(2)28-19-18(26-21(28)25-17-7-5-4-6-16(17)22)12-23-20(27-19)24-14-8-10-15(29-3)11-9-14/h4-13H,1-3H3,(H,25,26)(H,23,24,27) QVEWXFMWNGGSAH-UHFFFAOYSA-N 50363458 CHEMBL1946336 Mitogen-activated protein kinase 10 Homo sapiens 96 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363458&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24810997 136967520 CHEMBL1946336 ZINC82151948 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715933 COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C4CCCCC4)c3n2)cc1 InChI=1S/C24H25FN6O/c1-32-18-13-11-16(12-14-18)27-23-26-15-21-22(30-23)31(17-7-3-2-4-8-17)24(29-21)28-20-10-6-5-9-19(20)25/h5-6,9-15,17H,2-4,7-8H2,1H3,(H,28,29)(H,26,27,30) IPXACKINLSGATE-UHFFFAOYSA-N 50363459 CHEMBL1946337 Mitogen-activated protein kinase 10 Homo sapiens 360 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363459&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24810996 136967521 CHEMBL1946337 ZINC82151950 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715934 COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(-c4ccccc4)c3n2)cc1 InChI=1S/C24H19FN6O/c1-32-18-13-11-16(12-14-18)27-23-26-15-21-22(30-23)31(17-7-3-2-4-8-17)24(29-21)28-20-10-6-5-9-19(20)25/h2-15H,1H3,(H,28,29)(H,26,27,30) CCMGXJGEWZSKPA-UHFFFAOYSA-N 50363460 CHEMBL1946338 Mitogen-activated protein kinase 10 Homo sapiens >300 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363460&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24810995 136967522 CHEMBL1946338 ZINC73198522 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715935 COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n([C@H]4CC[C@H](N)CC4)c3n2)cc1 InChI=1S/C24H26FN7O/c1-33-18-12-8-16(9-13-18)28-23-27-14-21-22(31-23)32(17-10-6-15(26)7-11-17)24(30-21)29-20-5-3-2-4-19(20)25/h2-5,8-9,12-15,17H,6-7,10-11,26H2,1H3,(H,29,30)(H,27,28,31)/t15-,17- RHLSCLBSPZIGFS-JCNLHEQBSA-N 50363461 CHEMBL1946339 Mitogen-activated protein kinase 10 Homo sapiens 240 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363461&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57390520 136967523 CHEMBL1946339 ZINC82156821 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715936 COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n([C@@H]4CC[C@H](O)CC4)c3n2)cc1 InChI=1S/C24H25FN6O2/c1-33-18-12-6-15(7-13-18)27-23-26-14-21-22(30-23)31(16-8-10-17(32)11-9-16)24(29-21)28-20-5-3-2-4-19(20)25/h2-7,12-14,16-17,32H,8-11H2,1H3,(H,28,29)(H,26,27,30)/t16-,17+ LRVSISWQSCNQKL-CALCHBBNSA-N 50363462 CHEMBL1946340 Mitogen-activated protein kinase 10 Homo sapiens 17 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363462&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57394043 136967524 CHEMBL1946340 ZINC73197000 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715937 COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n([C@@H]4CC[C@@H](CC4)C(N)=O)c3n2)cc1 InChI=1S/C25H26FN7O2/c1-35-18-12-8-16(9-13-18)29-24-28-14-21-23(32-24)33(17-10-6-15(7-11-17)22(27)34)25(31-21)30-20-5-3-2-4-19(20)26/h2-5,8-9,12-15,17H,6-7,10-11H2,1H3,(H2,27,34)(H,30,31)(H,28,29,32)/t15-,17+ NZNGPQXBCNZDCZ-WOVMCDHWSA-N 50363464 CHEMBL1946495 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363464&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57395293 136967526 CHEMBL1946495 ZINC82149603 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715938 N[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cccc3F)n(C3CCCC3)c2n1 InChI=1S/C22H27F2N7/c23-16-6-3-7-17(24)19(16)29-22-28-18-12-26-21(27-14-10-8-13(25)9-11-14)30-20(18)31(22)15-4-1-2-5-15/h3,6-7,12-15H,1-2,4-5,8-11,25H2,(H,28,29)(H,26,27,30)/t13-,14- JSDUDTFXRSCOHV-HDJSIYSDSA-N 50363465 CHEMBL1946646 Mitogen-activated protein kinase 10 Homo sapiens 13 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363465&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57397040 136967527 CHEMBL1946646 ZINC73199229 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715939 N[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n(C3CCCC3)c2n1 InChI=1S/C22H26F3N7/c23-12-9-16(24)19(17(25)10-12)30-22-29-18-11-27-21(28-14-7-5-13(26)6-8-14)31-20(18)32(22)15-3-1-2-4-15/h9-11,13-15H,1-8,26H2,(H,29,30)(H,27,28,31)/t13-,14- MLIRIWBFADTRLZ-HDJSIYSDSA-N 50363466 CHEMBL1946647 Mitogen-activated protein kinase 10 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363466&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57393560 136967528 CHEMBL1946647 ZINC73198666 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715940 N[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3ccc(F)cc3F)n(C3CCCC3)c2n1 InChI=1S/C22H27F2N7/c23-13-5-10-18(17(24)11-13)28-22-29-19-12-26-21(27-15-8-6-14(25)7-9-15)30-20(19)31(22)16-3-1-2-4-16/h5,10-12,14-16H,1-4,6-9,25H2,(H,28,29)(H,26,27,30)/t14-,15- MKUCYQPSROSPGD-SHTZXODSSA-N 50363467 CHEMBL1946837 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363467&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56834943 136967529 CHEMBL1946837 ZINC82150514 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50718335 O[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@@H]3CCOC3)c2n1 InChI=1S/C21H23F3N6O2/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29)/t12-,13-,14-/m1/s1 IBGLGMOPHJQDJB-MGPQQGTHSA-N 50364376 CHEMBL1950303 Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2011.12.027 10.7270/Q2C829SK 22244937 Plantevin Krenitsky, V; Nadolny, L; Delgado, M; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Hegde, S; D'Sidocky, N; Sapienza, J; Wright, J; McCarrick, M; Bahmanyar, S; Chamberlain, P; Delker, SL; Muir, J; Giegel, D; Xu, L; Celeridad, M; Lachowitzer, J; Bennett, B; Moghaddam, M; Khatsenko, O; Katz, J; Fan, R; Bai, A; Tang, Y; Shirley, MA; Benish, B; Bodine, T; Blease, K; Raymon, H; Cathers, BE; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50364376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50364376&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57394468 136968438 CHEMBL1950303 ZINC82154361 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50718339 CNC(=O)[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1 InChI=1S/C23H26F3N7O2/c1-27-21(34)12-2-4-14(5-3-12)29-22-28-10-18-20(32-22)33(15-6-7-35-11-15)23(30-18)31-19-16(25)8-13(24)9-17(19)26/h8-10,12,14-15H,2-7,11H2,1H3,(H,27,34)(H,30,31)(H,28,29,32)/t12-,14-,15-/m0/s1 YEBFCGFMUQJOCV-QEJZJMRPSA-N 50364377 CHEMBL1950304 Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1016/j.bmcl.2011.12.027 10.7270/Q2C829SK 22244937 Plantevin Krenitsky, V; Nadolny, L; Delgado, M; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Hegde, S; D'Sidocky, N; Sapienza, J; Wright, J; McCarrick, M; Bahmanyar, S; Chamberlain, P; Delker, SL; Muir, J; Giegel, D; Xu, L; Celeridad, M; Lachowitzer, J; Bennett, B; Moghaddam, M; Khatsenko, O; Katz, J; Fan, R; Bai, A; Tang, Y; Shirley, MA; Benish, B; Bodine, T; Blease, K; Raymon, H; Cathers, BE; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50364377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50364377&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57392739 136968439 CHEMBL1950304 ZINC73198041 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50718343 O[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1 InChI=1S/C21H23F3N6O2/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29)/t12-,13-,14-/m0/s1 IBGLGMOPHJQDJB-IHRRRGAJSA-N 50364378 CHEMBL1950289 Mitogen-activated protein kinase 10 Homo sapiens 6 ChEMBL 10.1016/j.bmcl.2011.12.027 10.7270/Q2C829SK 22244937 Plantevin Krenitsky, V; Nadolny, L; Delgado, M; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Hegde, S; D'Sidocky, N; Sapienza, J; Wright, J; McCarrick, M; Bahmanyar, S; Chamberlain, P; Delker, SL; Muir, J; Giegel, D; Xu, L; Celeridad, M; Lachowitzer, J; Bennett, B; Moghaddam, M; Khatsenko, O; Katz, J; Fan, R; Bai, A; Tang, Y; Shirley, MA; Benish, B; Bodine, T; Blease, K; Raymon, H; Cathers, BE; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50364378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50364378&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search KBI 3TTI 11597537 136968440 CHEMBL1950289 ZINC35902440 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715962 COc1ccc(Nc2ncc3nc(Nc4ccccc4F)n(C4CCOCC4)c3n2)cc1 InChI=1S/C23H23FN6O2/c1-31-17-8-6-15(7-9-17)26-22-25-14-20-21(29-22)30(16-10-12-32-13-11-16)23(28-20)27-19-5-3-2-4-18(19)24/h2-9,14,16H,10-13H2,1H3,(H,27,28)(H,25,26,29) QXNPNLLIZGVUPQ-UHFFFAOYSA-N 50363463 CHEMBL1946341 Mitogen-activated protein kinase 10 Homo sapiens 63 ChEMBL 10.1016/j.bmcl.2011.12.028 10.7270/Q2513ZP6 22226655 Krenitsky, VP; Delgado, M; Nadolny, L; Sahasrabudhe, K; Ayala, L; Clareen, SS; Hilgraf, R; Albers, R; Kois, A; Hughes, K; Wright, J; Nowakowski, J; Sudbeck, E; Ghosh, S; Bahmanyar, S; Chamberlain, P; Muir, J; Cathers, BE; Giegel, D; Xu, L; Celeridad, M; Moghaddam, M; Khatsenko, O; Omholt, P; Katz, J; Pai, S; Fan, R; Tang, Y; Shirley, MA; Benish, B; Blease, K; Raymon, H; Bhagwat, S; Henderson, I; Cole, AG; Bennett, B; Satoh, Y Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363463&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57395802 136967525 CHEMBL1946341 ZINC73197001 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50819173 FC(F)(F)c1cccc(NC(=O)c2csc(n2)-c2ccncc2)c1 InChI=1S/C16H10F3N3OS/c17-16(18,19)11-2-1-3-12(8-11)21-14(23)13-9-24-15(22-13)10-4-6-20-7-5-10/h1-9H,(H,21,23) AIFPXANKFYDRSD-UHFFFAOYSA-N 50149200 2-Pyridin-4-yl-thiazole-4-carboxylic acid (3-trifluoromethyl-phenyl)-amide::CHEMBL117121::cid_1483690 Mitogen-activated protein kinase 10 Homo sapiens 13000 ChEMBL 10.1021/jm040031v 10.7270/Q2NC61ZJ 15214773 Erlanson, DA; McDowell, RS; O'Brien, T Sunesis Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50149200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50149200&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1483690 104037358 CHEMBL117121 ZINC01397252 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50819229 O=C(Nc1ccccc1)c1c(Nc2ccccc2)[nH]c(=O)[nH]c1=O InChI=1S/C17H14N4O3/c22-15(19-12-9-5-2-6-10-12)13-14(20-17(24)21-16(13)23)18-11-7-3-1-4-8-11/h1-10H,(H,19,22)(H3,18,20,21,23,24) KHEDUPJKNPEZBB-UHFFFAOYSA-N 50149239 2,4-Dioxo-6-phenylamino-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid phenylamide::CHEMBL117120 Mitogen-activated protein kinase 10 Homo sapiens 720 ChEMBL 10.1021/jm040031v 10.7270/Q2NC61ZJ 15214773 Erlanson, DA; McDowell, RS; O'Brien, T Sunesis Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50149239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50149239&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9818586 104037394 CHEMBL117120 ZINC00008923 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50829216 N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1 InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) RCYPVQCPYKNSTG-UHFFFAOYSA-N 50169959 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile::AS-601245::AS601245::CHEMBL1788116::CHEMBL191384::[3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1021/jm0310986 10.7270/Q2K9389G 15999997 Gaillard, P; Jeanclaude-Etter, I; Ardissone, V; Arkinstall, S; Cambet, Y; Camps, M; Chabert, C; Church, D; Cirillo, R; Gretener, D; Halazy, S; Nichols, A; Szyndralewiez, C; Vitte, PA; Gotteland, JP Serono Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169959&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JN5 3CY3 10109823 104054707 CHEMBL1788116CHEMBL191384 5997 ZINC13647791 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50840599 C[C@@H]1C[C@H]2CN1CCn1[nH]c3c(cccc3c1=O)-c1nc3c(O2)cccc3[nH]c1=O InChI=1S/C22H21N5O3/c1-12-10-13-11-26(12)8-9-27-22(29)15-5-2-4-14(18(15)25-27)19-21(28)23-16-6-3-7-17(30-13)20(16)24-19/h2-7,12-13,25H,8-11H2,1H3,(H,23,28)/t12-,13+/m1/s1 KBLPHMRCKHFBJB-OLZOCXBDSA-N 50192071 (13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahexacyclo[15.6.2.1^{6,9}.1^{12,15}.0^{2,7}.0^{21,25}]heptacosa-1(24),2,4,6(27),7,17(25),18,20,22-nonaene-23,27-diol::CHEMBL215803 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2006.07.026 10.7270/Q2K35VF0 16876403 Kawanishi, N; Sugimoto, T; Shibata, J; Nakamura, K; Masutani, K; Ikuta, M; Hirai, H Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192071&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1CD 2DS1 16046126 104075026 CHEMBL215803 DB06888 ZINC36770746 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50865042 N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1 InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) RCYPVQCPYKNSTG-UHFFFAOYSA-N 50169959 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile::AS-601245::AS601245::CHEMBL1788116::CHEMBL191384::[3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1073/pnas.0708800104 10.7270/Q2DB82RH 18077363 Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Muller, S; Bullock, AN; Schwaller, J; Sundstrom, M; Knapp, S University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169959&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JN5 3CY3 10109823 104054707 CHEMBL1788116CHEMBL191384 5997 ZINC13647791 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50866275 COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(cc1)S(C)(=O)=O InChI=1S/C25H20BrNO5S/c1-32-25(29)23-22(17-6-4-3-5-7-17)21-14-18(26)10-13-20(21)24(28)27(23)15-16-8-11-19(12-9-16)33(2,30)31/h3-14H,15H2,1-2H3 WNTHBRVKPVTIQB-UHFFFAOYSA-N 50373215 CHEMBL259060 Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1016/j.bmc.2008.02.028 10.7270/Q2NP2598 18313930 Asano, Y; Kitamura, S; Ohra, T; Itoh, F; Kajino, M; Tamura, T; Kaneko, M; Ikeda, S; Igata, H; Kawamoto, T; Sogabe, S; Matsumoto, S; Tanaka, T; Yamaguchi, M; Kimura, H; Fukumoto, S Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373215&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9958506 160852316 CHEMBL259060 ZINC03925054 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50863988 Nc1nccn2c(nc(-c3ccc4ccc(nc4c3)-c3ccccc3)c12)[C@@H]1C[C@H](CN2CCC2)C1 InChI=1S/C29H28N6/c30-28-27-26(22-8-7-21-9-10-24(32-25(21)17-22)20-5-2-1-3-6-20)33-29(35(27)14-11-31-28)23-15-19(16-23)18-34-12-4-13-34/h1-3,5-11,14,17,19,23H,4,12-13,15-16,18H2,(H2,30,31)/t19-,23+ FUGZYLOFWXVFQU-OKDJAKQTSA-N 50336316 CHEMBL410659::cis-3-(3-(azetidin-1-ylmethyl)cyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine::cis-3-(3-azetidin-1-ylmethylcyclobutyl)-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-ylamine Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2007.10.061 10.7270/Q2WH2QVH 17983756 Mulvihill, MJ; Ji, QS; Coate, HR; Cooke, A; Dong, H; Feng, L; Foreman, K; Rosenfeld-Franklin, M; Honda, A; Mak, G; Mulvihill, KM; Nigro, AI; O'Connor, M; Pirrit, C; Steinig, AG; Siu, K; Stolz, KM; Sun, Y; Tavares, PA; Yao, Y; Gibson, NW OSI Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50336316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50336316&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11583459 125086418 CHEMBL410659 ZINC29059823 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50872417 Oc1cc2C[C@@H]3c4cc(O)c(O)cc4C[C@H]4c5cc(O)c(O)cc5CC[N@@+]34c2cc1O InChI=1S/C24H21NO6/c26-19-5-11-1-2-25-16-10-24(31)21(28)7-13(16)4-18(25)15-9-23(30)20(27)6-12(15)3-17(25)14(11)8-22(19)29/h5-10,17-18H,1-4H2,(H5-,26,27,28,29,30,31)/p+1/t17-,18+,25-/m0/s1 PTYAOGZKZAVRNA-ATLLOTDBSA-O 50377942 LATIFOLIAN A Mitogen-activated protein kinase 10 Homo sapiens 13000 ChEMBL 10.1021/np049616i 10.7270/Q21V5FV1 16038553 Rochfort, SJ; Towerzey, L; Carroll, A; King, G; Michael, A; Pierens, G; Rali, T; Redburn, J; Whitmore, J; Quinn, RJ Griffith University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377942&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11478148 160857025 68905 ZINC40423191 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50872418 COc1cc2c(C[C@@H]3c4cc(O)c(O)cc4C[C@H]4c5cc(O)c(O)cc5CC[N@@+]234)cc1O InChI=1S/C25H23NO6/c1-32-25-11-17-14(8-24(25)31)5-19-16-10-23(30)21(28)7-13(16)4-18-15-9-22(29)20(27)6-12(15)2-3-26(17,18)19/h6-11,18-19H,2-5H2,1H3,(H4-,27,28,29,30,31)/p+1/t18-,19+,26-/m0/s1 QAXHHTKPOZDKNR-ANSQWYIGSA-O 50377943 LATIFOLIAN B Mitogen-activated protein kinase 10 Homo sapiens 10000 ChEMBL 10.1021/np049616i 10.7270/Q21V5FV1 16038553 Rochfort, SJ; Towerzey, L; Carroll, A; King, G; Michael, A; Pierens, G; Rali, T; Redburn, J; Whitmore, J; Quinn, RJ Griffith University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377943&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11353317 160857026 ZINC42878861 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50862508 CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n2c(nc4ccccc24)n(-c2c(C)cccc2C)c3=O)cc1 InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14,19H,15-18H2,1-3H3,(H,32,33,35) BHJJWVDKNXABFS-UHFFFAOYSA-N 50374608 CHEMBL410295 Mitogen-activated protein kinase 10 Homo sapiens 7300 ChEMBL 10.1021/jm701095m 10.7270/Q23B6114 18278858 Martin, MW; Newcomb, J; Nunes, JJ; Boucher, C; Chai, L; Epstein, LF; Faust, T; Flores, S; Gallant, P; Gore, A; Gu, Y; Hsieh, F; Huang, X; Kim, JL; Middleton, S; Morgenstern, K; Oliveira-dos-Santos, A; Patel, VF; Powers, D; Rose, P; Tudor, Y; Turci, SM; Welcher, AA; Zack, D; Zhao, H; Zhu, L; Zhu, X; Ghiron, C; Ermann, M; Johnston, D; Saluste, CG Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374608&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search AM9 3BYO 11785878 160853698 CHEMBL410295 ZINC53214756 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50858989 COC(=O)c1c(-c2ccccc2)c2cc(Br)ccc2c(=O)n1Cc1ccc(cc1)S(C)(=O)=O InChI=1S/C25H20BrNO5S/c1-32-25(29)23-22(17-6-4-3-5-7-17)21-14-18(26)10-13-20(21)24(28)27(23)15-16-8-11-19(12-9-16)33(2,30)31/h3-14H,15H2,1-2H3 WNTHBRVKPVTIQB-UHFFFAOYSA-N 50373215 CHEMBL259060 Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1016/j.bmc.2008.02.027 10.7270/Q2JS9R8M 18313304 Asano, Y; Kitamura, S; Ohra, T; Aso, K; Igata, H; Tamura, T; Kawamoto, T; Tanaka, T; Sogabe, S; Matsumoto, S; Yamaguchi, M; Kimura, H; Itoh, F Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373215&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9958506 160852316 CHEMBL259060 ZINC03925054 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50864936 CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23) KQMPRSZTUSSXND-UHFFFAOYSA-N 15908 Aminopyridine-Based Inhibitor 6o::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide::aminopyridine deriv. 2 Mitogen-activated protein kinase 10 Homo sapiens 52 ChEMBL 10.1073/pnas.0708800104 10.7270/Q2DB82RH 18077363 Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Muller, S; Bullock, AN; Schwaller, J; Sundstrom, M; Knapp, S University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15908&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11624601 46516179 5998 ZINC14959960 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892703 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892704 CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ WVUNYSQLFKLYNI-AATRIKPKSA-N 31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 93J 7AXM,5VCW 6445562 252615337 38927 ZINC00602803 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892705 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50878962 Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(NC(=O)c2ccnc(c2)N2CCCC2)ccc1C InChI=1S/C27H27N5O2/c1-17-6-8-22(29-26(33)20-10-11-28-25(15-20)32-12-4-5-13-32)16-24(17)23-9-7-21(14-18(23)2)27-31-30-19(3)34-27/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,29,33) OBHNTFJGFUEQCQ-UHFFFAOYSA-N 50265035 CHEMBL495729::N-(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-yl)-2-(pyrrolidin-1-yl)isonicotinamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265035&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10479082 104112853 CHEMBL495729 ZINC38941486 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50878972 Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)NC1CC1 InChI=1S/C23H25N3O2/c1-14-2-3-17(23(27)25-18-5-6-18)12-20(14)16-4-7-19-21(13-16)28-26-22(19)15-8-10-24-11-9-15/h2-4,7,12-13,15,18,24H,5-6,8-11H2,1H3,(H,25,27) UEWLDVUSFNQXKA-UHFFFAOYSA-N 50265371 CHEMBL497563::N-cyclopropyl-4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-6-yl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265371&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9864418 104113148 CHEMBL497563 ZINC03938228 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50878982 Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)NC1CC1 InChI=1S/C21H21N3O2/c1-12-4-5-15(20(25)22-17-7-8-17)11-19(12)18-9-6-16(10-13(18)2)21-24-23-14(3)26-21/h4-6,9-11,17H,7-8H2,1-3H3,(H,22,25) UBVTVSINEVHYSY-UHFFFAOYSA-N 50265033 CHEMBL522579::N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265033&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search G6A 3E92 10089048 104112851 CHEMBL522579 DB07811 ZINC33969098 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50878991 Cc1ccc(cc1-c1ccc2c(c1)nnn(CC1CC1)c2=O)C(=O)NC1CC1 InChI=1S/C22H22N4O2/c1-13-2-5-16(21(27)23-17-7-8-17)10-19(13)15-6-9-18-20(11-15)24-25-26(22(18)28)12-14-3-4-14/h2,5-6,9-11,14,17H,3-4,7-8,12H2,1H3,(H,23,27) GURGQFBRXVKIQG-UHFFFAOYSA-N 50265154 CHEMBL521734::N-cyclopropyl-3-(3-(cyclopropylmethyl)-4-oxo-3,4-dihydrobenzo[d][1,2,3]triazin-7-yl)-4-methylbenzamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265154&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44580532 104112950 CHEMBL521734 ZINC40974802 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50879000 Cc1ccc(cc1-c1ccc2ccncc2c1)C(=O)NC1CC1 InChI=1S/C20H18N2O/c1-13-2-3-16(20(23)22-18-6-7-18)11-19(13)15-5-4-14-8-9-21-12-17(14)10-15/h2-5,8-12,18H,6-7H2,1H3,(H,22,23) VAGUQCZJQQNYIR-UHFFFAOYSA-N 50265259 CHEMBL526639::N-cyclopropyl-3-(isoquinolin-7-yl)-4-methylbenzamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265259&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44580649 104113048 CHEMBL526639 ZINC40973029 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50879010 Cc1ccc(cc1-c1ccc(cc1)C(=O)NCC1CC1)C(=O)NC1CC1 InChI=1S/C22H24N2O2/c1-14-2-5-18(22(26)24-19-10-11-19)12-20(14)16-6-8-17(9-7-16)21(25)23-13-15-3-4-15/h2,5-9,12,15,19H,3-4,10-11,13H2,1H3,(H,23,25)(H,24,26) BOPSUAHGQHFKGG-UHFFFAOYSA-N 50263093 6-Methyl-biphenyl-3,4'-dicarboxylic acid 3-cyclopropylamide 4'-cyclopropylmethyl-amide::CHEMBL478649::N3-cyclopropyl-N4'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide::N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263093&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search GK5 3D7Z 24856363 104111567 CHEMBL478649 DB07835 ZINC03961852 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50879019 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(c2)-c2ccc(cc2C)-c2nnc(C)o2)CC1 InChI=1S/C30H33N5O2/c1-20-5-11-26(18-28(20)27-12-10-25(17-21(27)2)30-33-32-22(3)37-30)31-29(36)24-8-6-23(7-9-24)19-35-15-13-34(4)14-16-35/h5-12,17-18H,13-16,19H2,1-4H3,(H,31,36) HSCYIVKNKNXHIF-UHFFFAOYSA-N 50265069 CHEMBL497350::N-(2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265069&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44580449 104112882 CHEMBL497350 ZINC40975401 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892863 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Mitogen-activated protein kinase 10 Homo sapiens 5500 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892864 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Mitogen-activated protein kinase 10 Homo sapiens 3200 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892865 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892866 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Mitogen-activated protein kinase 10 Homo sapiens 1900 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892867 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Mitogen-activated protein kinase 10 Homo sapiens 3100 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search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itogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892868 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Mitogen-activated protein kinase 10 Homo sapiens 1300 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892869 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892870 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892871 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892872 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892873 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892875 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892876 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892877 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Mitogen-activated protein kinase 10 Homo sapiens 42 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892878 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Mitogen-activated protein kinase 10 Homo sapiens 35 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892879 NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1 InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) FHYUGAJXYORMHI-UHFFFAOYSA-N 50110208 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::4-(5-(benzo[d][1,3]dioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(5-benzo[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::CHEMBL440084::SB-431542::cid_4521392 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110208&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 085 3TZM 4521392 104005054 CHEMBL440084 ZINC00603769 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50892880 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50879028 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(c2)-c2ccc3ccncc3c2)CC1 InChI=1S/C29H30N4O/c1-21-3-10-27(18-28(21)25-9-8-23-11-12-30-19-26(23)17-25)31-29(34)24-6-4-22(5-7-24)20-33-15-13-32(2)14-16-33/h3-12,17-19H,13-16,20H2,1-2H3,(H,31,34) IYCITBYBDPSBBJ-UHFFFAOYSA-N 50265287 CHEMBL521887::N-(3-(isoquinolin-7-yl)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265287&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44580689 104113075 CHEMBL521887 ZINC40428835 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50879037 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(c2)-c2ccc3c(N)noc3c2)CC1 InChI=1S/C27H29N5O2/c1-18-3-9-22(16-24(18)21-8-10-23-25(15-21)34-30-26(23)28)29-27(33)20-6-4-19(5-7-20)17-32-13-11-31(2)12-14-32/h3-10,15-16H,11-14,17H2,1-2H3,(H2,28,30)(H,29,33) BGLPZSPBYFJHQQ-UHFFFAOYSA-N 50265370 CHEMBL497353::N-(3-(3-aminobenzo[d]isoxazol-6-yl)-4-methylphenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265370&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44580778 104113147 CHEMBL497353 ZINC40975685 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50879046 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(c2)-c2ccc(cc2)-c2csc(N)n2)CC1 InChI=1S/C29H31N5OS/c1-20-3-12-25(17-26(20)22-8-10-23(11-9-22)27-19-36-29(30)32-27)31-28(35)24-6-4-21(5-7-24)18-34-15-13-33(2)14-16-34/h3-12,17,19H,13-16,18H2,1-2H3,(H2,30,32)(H,31,35) BGOWMSRXCRUANU-UHFFFAOYSA-N 50264990 CHEMBL496129::N-(4'-(2-aminothiazol-4-yl)-6-methylbiphenyl-3-yl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264990&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44580358 104112819 CHEMBL496129 ZINC40952530 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50890737 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50890738 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50890739 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Mitogen-activated protein kinase 10 Homo sapiens 2800 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50890740 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50890741 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50883382 NCc1ccc(cc1)-c1cnc2[nH]cc(-c3cccc(NC(=O)Nc4ccc(cc4F)C(F)(F)F)c3)c2c1 InChI=1S/C28H21F4N5O/c29-24-12-20(28(30,31)32)8-9-25(24)37-27(38)36-21-3-1-2-18(10-21)23-15-35-26-22(23)11-19(14-34-26)17-6-4-16(13-33)5-7-17/h1-12,14-15H,13,33H2,(H,34,35)(H2,36,37,38) RDNOLDWOMGZBPI-UHFFFAOYSA-N 50293532 1-(3-(5-(4-(aminomethyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)urea::CHEMBL551024 Mitogen-activated protein kinase 10 Homo sapiens 250 ChEMBL 10.1016/j.bmcl.2008.12.110 10.7270/Q2DV1KSP 19394223 Patnaik, S; Stevens, KL; Gerding, R; Deanda, F; Shotwell, JB; Tang, J; Hamajima, T; Nakamura, H; Leesnitzer, MA; Hassell, AM; Shewchuck, LM; Kumar, R; Lei, H; Chamberlain, SD GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50293532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50293532&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 45270368 104135083 CHEMBL551024 ZINC43063728 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891427 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891428 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891429 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Mitogen-activated protein kinase 10 Homo sapiens 760 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891430 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891431 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891432 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891433 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891434 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891435 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Mitogen-activated protein kinase 10 Homo sapiens 5500 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891436 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50891437 COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+ LLVZBTWPGQVVLW-SNAWJCMRSA-N 31340 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide::2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide::CHEMBL483321::CP-724714::cid_9874913 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31340&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 9874913 252615341 CHEMBL483321 ZINC03817105 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50878932 Cc1ccc(cc1-c1ccc2c(noc2c1)C1CCNCC1)C(=O)Nc1cccc(c1)N1CCOCC1 InChI=1S/C30H32N4O3/c1-20-5-6-23(30(35)32-24-3-2-4-25(19-24)34-13-15-36-16-14-34)17-27(20)22-7-8-26-28(18-22)37-33-29(26)21-9-11-31-12-10-21/h2-8,17-19,21,31H,9-16H2,1H3,(H,32,35) UVUGBBNUQBSROH-UHFFFAOYSA-N 50264755 4-methyl-N-(3-morpholin-4-ylphenyl)-3-(3-piperidin-4-yl-1,2-benzisoxazol-6-yl)benzamide::4-methyl-N-(3-morpholinophenyl)-3-(3-(piperidin-4-yl)benzo[d]isoxazol-6-yl)benzamide::CHEMBL485285 Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264755&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 19B 3E93 9983303 104112664 CHEMBL485285 ZINC03938229 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50878942 Cc1nnc(o1)-c1ccc(c(C)c1)-c1cc(ccc1C)C(=O)Nc1cccc(c1)N1CCOCC1 InChI=1S/C28H28N4O3/c1-18-7-8-21(27(33)29-23-5-4-6-24(17-23)32-11-13-34-14-12-32)16-26(18)25-10-9-22(15-19(25)2)28-31-30-20(3)35-28/h4-10,15-17H,11-14H2,1-3H3,(H,29,33) NCEXHVFUAONAAE-UHFFFAOYSA-N 50265034 2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(3-morpholinophenyl)biphenyl-3-carboxamide::CHEMBL523559 Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265034&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44580420 104112852 CHEMBL523559 ZINC40429518 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50878952 Cc1ccc(NC(=O)c2ccnc(c2)N2CCCC2)cc1-c1ccc2c(noc2c1)C1CCNCC1 InChI=1S/C29H31N5O2/c1-19-4-6-23(32-29(35)22-10-13-31-27(17-22)34-14-2-3-15-34)18-25(19)21-5-7-24-26(16-21)36-33-28(24)20-8-11-30-12-9-20/h4-7,10,13,16-18,20,30H,2-3,8-9,11-12,14-15H2,1H3,(H,32,35) DMTJDVSGJMJVRQ-UHFFFAOYSA-N 50264756 CHEMBL485286::N-(4-methyl-3-(3-(piperidin-4-yl)benzo[d]isoxazol-6-yl)phenyl)-2-(pyrrolidin-1-yl)isonicotinamide Mitogen-activated protein kinase 10 Homo sapiens >16000 ChEMBL 10.1016/j.bmcl.2008.08.051 10.7270/Q28K7B0R 18789685 Baldwin, I; Bamborough, P; Haslam, CG; Hunjan, SS; Longstaff, T; Mooney, CJ; Patel, S; Quinn, J; Somers, DO GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50264756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50264756&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44580077 104112665 CHEMBL485286 ZINC40937453 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906348 N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1 InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) RCYPVQCPYKNSTG-UHFFFAOYSA-N 50169959 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile::AS-601245::AS601245::CHEMBL1788116::CHEMBL191384::[3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile Mitogen-activated protein kinase 10 Homo sapiens 120 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169959&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JN5 3CY3 10109823 104054707 CHEMBL1788116CHEMBL191384 5997 ZINC13647791 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906360 NC(=O)c1ccc(Nc2nccc(n2)-c2ccccc2)cc1 InChI=1S/C17H14N4O/c18-16(22)13-6-8-14(9-7-13)20-17-19-11-10-15(21-17)12-4-2-1-3-5-12/h1-11H,(H2,18,22)(H,19,20,21) NEBNIXUGANAKDR-UHFFFAOYSA-N 50303636 4-(4-Phenylpyrimidin-2-ylamino)benzamide::CHEMBL571619 Mitogen-activated protein kinase 10 Homo sapiens 491 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627578 104157997 CHEMBL571619 ZINC45286250 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906361 N(c1ccc(cc1)-n1cncn1)c1nccc(n1)-c1ccccc1 InChI=1S/C18H14N6/c1-2-4-14(5-3-1)17-10-11-20-18(23-17)22-15-6-8-16(9-7-15)24-13-19-12-21-24/h1-13H,(H,20,22,23) HTCYTPVYZPLGTO-UHFFFAOYSA-N 50303647 CHEMBL572282::N-(4-(1H-1,2,4-Triazol-1-yl)phenyl)-4-phenylpyrimidin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 297 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303647&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627579 104158008 CHEMBL572282 ZINC45285746 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906362 C1CN(CCO1)c1cccc(c1)-c1ccnc(Nc2ccc(cc2)-n2ccnn2)n1 InChI=1S/C22H21N7O/c1-2-17(16-20(3-1)28-12-14-30-15-13-28)21-8-9-23-22(26-21)25-18-4-6-19(7-5-18)29-11-10-24-27-29/h1-11,16H,12-15H2,(H,23,25,26) KXYHQCXHGCREEU-UHFFFAOYSA-N 50303637 CHEMBL572283::N-(4-(1H-1,2,3-Triazol-1-yl)phenyl)-4-(3-morpholinophenyl)-pyrimidin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 365 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303637&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627580 104157998 CHEMBL572283 ZINC45285748 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906363 CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1 InChI=1S/C17H17N5O4S2/c1-27(23,24)22-14-4-2-12(3-5-14)16-10-11-19-17(21-16)20-13-6-8-15(9-7-13)28(18,25)26/h2-11,22H,1H3,(H2,18,25,26)(H,19,20,21) VXVYIKQQPFNMED-UHFFFAOYSA-N 50303638 4-(4-(4-(Methylsulfonamido)phenyl)pyrimidin-2-ylamino)benzenesulfonamide::CHEMBL585916 Mitogen-activated protein kinase 10 Homo sapiens 7 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303638&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627581 104157999 CHEMBL585916 ZINC45335284 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906364 CS(=O)(=O)Nc1ccc(cc1)-c1ccnc(Nc2ccc(cc2)-n2ccnn2)n1 InChI=1S/C19H17N7O2S/c1-29(27,28)24-16-4-2-14(3-5-16)18-10-11-20-19(23-18)22-15-6-8-17(9-7-15)26-13-12-21-25-26/h2-13,24H,1H3,(H,20,22,23) MDCMULVKRBERMG-UHFFFAOYSA-N 50303639 CHEMBL571626::N-(4-(2-(4-(1H-1,2,3-Triazol-1-yl)phenylamino)pyrimidin-4-yl)-phenyl)methanesulfonamide Mitogen-activated protein kinase 10 Homo sapiens 4 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303639&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627582 104158000 CHEMBL571626 ZINC45286868 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906365 Cc1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cccc(c2)N2CCOCC2)cc1 InChI=1S/C23H23N7O/c1-17-25-16-30(28-17)20-7-5-19(6-8-20)26-23-24-10-9-22(27-23)18-3-2-4-21(15-18)29-11-13-31-14-12-29/h2-10,15-16H,11-14H2,1H3,(H,24,26,27) YMHGDVJMGNXBIG-UHFFFAOYSA-N 50303640 CHEMBL585725::N-(4-(3-Methyl-1H-1,2,4-triazol-1-yl)phenyl)-4-(3-morpholinophenyl)pyrimidin-2-amine Mitogen-activated protein kinase 10 Homo sapiens 390 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303640&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627583 104158001 CHEMBL585725 ZINC45334818 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906366 Cc1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cc(cc(c2)N2CCOCC2)C#N)cc1 InChI=1S/C24H22N8O/c1-17-27-16-32(30-17)21-4-2-20(3-5-21)28-24-26-7-6-23(29-24)19-12-18(15-25)13-22(14-19)31-8-10-33-11-9-31/h2-7,12-14,16H,8-11H2,1H3,(H,26,28,29) JKCOWGOVZGAWTE-UHFFFAOYSA-N 50303641 3-(2-(4-(3-Methyl-1H-1,2,4-triazol-1-yl)phenylamino)pyrimidin-4-yl)-5-morpholinobenzonitrile::CHEMBL570554 Mitogen-activated protein kinase 10 Homo sapiens 79 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303641&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627681 104158002 CHEMBL570554 ZINC45256298 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906367 Cn1nnc(n1)-c1ccc(Nc2nccc(n2)-c2cc(cc(c2)N2CCOCC2)C#N)cc1 InChI=1S/C23H21N9O/c1-31-29-22(28-30-31)17-2-4-19(5-3-17)26-23-25-7-6-21(27-23)18-12-16(15-24)13-20(14-18)32-8-10-33-11-9-32/h2-7,12-14H,8-11H2,1H3,(H,25,26,27) CEJFYMKXALJHTD-UHFFFAOYSA-N 50303642 3-(2-(4-(2-Methyl-2H-tetrazol-5-yl)phenylamino)pyrimidin-4-yl)-5-morpholinobenzonitrile::CHEMBL571434 Mitogen-activated protein kinase 10 Homo sapiens 140 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303642&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627682 104158003 CHEMBL571434 ZINC45284919 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906368 C1CN(CCO1)c1cccc(c1)-c1ccnc(Nc2ccc(cc2)-n2cnc(n2)-c2cccnc2)n1 InChI=1S/C27H24N8O/c1-3-20(17-24(5-1)34-13-15-36-16-14-34)25-10-12-29-27(32-25)31-22-6-8-23(9-7-22)35-19-30-26(33-35)21-4-2-11-28-18-21/h1-12,17-19H,13-16H2,(H,29,31,32) UNWYPVDZMQJENJ-UHFFFAOYSA-N 50303643 4-(3-Morpholinophenyl)-N-(4-(3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine::CHEMBL571023 Mitogen-activated protein kinase 10 Homo sapiens 85 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303643&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627683 104158004 CHEMBL571023 ZINC45260974 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906369 N#Cc1cc(cc(c1)-c1ccnc(Nc2ccc(cc2)-n2cnc(n2)-c2ccccn2)n1)N1CCOCC1 InChI=1S/C28H23N9O/c29-18-20-15-21(17-24(16-20)36-11-13-38-14-12-36)25-8-10-31-28(34-25)33-22-4-6-23(7-5-22)37-19-32-27(35-37)26-3-1-2-9-30-26/h1-10,15-17,19H,11-14H2,(H,31,33,34) VFBUSLHLJVREKP-UHFFFAOYSA-N 50303644 3-Morpholino-5-(2-(4-(3-(pyridin-2-yl)-1H-1,2,4-triazol-1-yl)-phenylamino)pyrimidin-4-yl)benzonitrile::CHEMBL584899 Mitogen-activated protein kinase 10 Homo sapiens 79 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303644&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25222587 104158005 CHEMBL584899 ZINC45318638 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906370 CN1CCN(CC1)c1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cc(F)cc(c2)N2CCOCC2)cc1 InChI=1S/C27H30FN9O/c1-34-8-10-36(11-9-34)27-30-19-37(33-27)23-4-2-22(3-5-23)31-26-29-7-6-25(32-26)20-16-21(28)18-24(17-20)35-12-14-38-15-13-35/h2-7,16-19H,8-15H2,1H3,(H,29,31,32) BYCDZWGPIIHWFV-UHFFFAOYSA-N 50303645 4-(3-Fluoro-5-morpholinophenyl)-N-(4-(3-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine::CHEMBL568116 Mitogen-activated protein kinase 10 Homo sapiens 133 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303645&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44627684 104158006 CHEMBL568116 ZINC45255313 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50906371 Fc1cc(cc(c1)-c1ccnc(Nc2ccc(cc2)-n2cnc(n2)N2CCOCC2)n1)N1CCOCC1 InChI=1S/C26H27FN8O2/c27-20-15-19(16-23(17-20)33-7-11-36-12-8-33)24-5-6-28-25(31-24)30-21-1-3-22(4-2-21)35-18-29-26(32-35)34-9-13-37-14-10-34/h1-6,15-18H,7-14H2,(H,28,30,31) AHMHIFXJPSHHPH-UHFFFAOYSA-N 50303646 4-(3-Fluoro-5-morpholinophenyl)-N-(4-(3-morpholino-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine::CHEMBL585951::N-[(2Z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1H)-ylidene]-4-(3-morpholin-4-yl-1H-1,2,4-triazol-1-yl)aniline Mitogen-activated protein kinase 10 Homo sapiens 148 ChEMBL 10.1021/jm901351f 10.7270/Q23T9J6J 19947601 Kamenecka, T; Jiang, R; Song, X; Duckett, D; Chen, W; Ling, YY; Habel, J; Laughlin, JD; Chambers, J; Figuera-Losada, M; Cameron, MD; Lin, L; Ruiz, CH; LoGrasso, PV Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50303646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50303646&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25222038 104158007 CHEMBL585951 ZINC44460355 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50910149 COc1ccc(cc1)-c1[nH][nH]c(=O)c1N=Nc1cccc(OC)c1 InChI=1S/C17H16N4O3/c1-23-13-8-6-11(7-9-13)15-16(17(22)21-19-15)20-18-12-4-3-5-14(10-12)24-2/h3-10H,1-2H3,(H2,19,21,22) AXEQDNRVEUBEKN-UHFFFAOYSA-N 50313050 (Z)-3-(4-methoxyphenyl)-4-(2-(3-methoxyphenyl)hydrazono)-1H-pyrazol-5(4H)-one::CHEMBL1080902 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2010.01.072 10.7270/Q2TX3G9B 20138514 Arnost, M; Pierce, A; ter Haar, E; Lauffer, D; Madden, J; Tanner, K; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313050&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46865325 104147411 CHEMBL1080902 ZINC49033769 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50910161 COc1ccc(cc1)-c1[nH][nH]c(=O)c1N=Nc1cccnc1 InChI=1S/C15H13N5O2/c1-22-12-6-4-10(5-7-12)13-14(15(21)20-18-13)19-17-11-3-2-8-16-9-11/h2-9H,1H3,(H2,18,20,21) KRHWSBXYWJHICK-UHFFFAOYSA-N 50313051 (Z)-3-(4-methoxyphenyl)-4-(2-(pyridin-3-yl)hydrazono)-1H-pyrazol-5(4H)-one::CHEMBL1076721 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2010.01.072 10.7270/Q2TX3G9B 20138514 Arnost, M; Pierce, A; ter Haar, E; Lauffer, D; Madden, J; Tanner, K; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313051&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 22353185 104147412 CHEMBL1076721 ZINC49525584 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50910192 COc1ccncc1-c1[nH][nH]c(=O)c1N=Nc1ccccc1 InChI=1S/C15H13N5O2/c1-22-12-7-8-16-9-11(12)13-14(15(21)20-18-13)19-17-10-5-3-2-4-6-10/h2-9H,1H3,(H2,18,20,21) NPLOHUPMKKUYFK-UHFFFAOYSA-N 50313061 (Z)-3-(4-methoxypyridin-3-yl)-4-(2-phenylhydrazono)-1H-pyrazol-5(4H)-one::CHEMBL1086736 Mitogen-activated protein kinase 10 Homo sapiens 2500 ChEMBL 10.1016/j.bmcl.2010.01.072 10.7270/Q2TX3G9B 20138514 Arnost, M; Pierce, A; ter Haar, E; Lauffer, D; Madden, J; Tanner, K; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50313061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50313061&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46880951 104147422 CHEMBL1086736 ZINC49049758 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50932022 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Mitogen-activated protein kinase 10 Homo sapiens >5000 ChEMBL 10.1021/ml2001455 10.7270/Q26D5V19 24900264 Duffy, JP; Harrington, EM; Salituro, FG; Cochran, JE; Green, J; Gao, H; Bemis, GW; Evindar, G; Galullo, VP; Ford, PJ; Germann, UA; Wilson, KP; Bellon, SF; Chen, G; Taslimi, P; Jones, P; Huang, C; Pazhanisamy, S; Wang, YM; Murcko, MA; Su, MS TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50921826 COc1ccc(Cn2ncc(NC(=O)c3cc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)ccc3C)c2N)cc1 InChI=1S/C27H24ClF3N6O3/c1-15-3-6-17(34-26(39)35-18-7-10-22(28)21(12-18)27(29,30)31)11-20(15)25(38)36-23-13-33-37(24(23)32)14-16-4-8-19(40-2)9-5-16/h3-13H,14,32H2,1-2H3,(H,36,38)(H2,34,35,39) ZJDFSKSBQBPOSK-UHFFFAOYSA-N 50338873 CHEMBL1684800::N-(5-Amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-2-methylbenzamide Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1016/j.bmc.2011.01.067 10.7270/Q2D79CD3 21353571 Kim, MH; Kim, M; Yu, H; Kim, H; Yoo, KH; Sim, T; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338873&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52938983 125088975 CHEMBL1684800 ZINC66147781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50951248 NC(=O)c1ccc(Oc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(OCCCN4CCCC4)cc3)cc2)cc1 InChI=1S/C30H29N3O4S2/c31-28(34)22-6-12-26(13-7-22)37-25-10-4-21(5-11-25)20-27-29(35)33(30(38)39-27)23-8-14-24(15-9-23)36-19-3-18-32-16-1-2-17-32/h4-15,20H,1-3,16-19H2,(H2,31,34)/b27-20- WUMAAYUBQASNEQ-OOAXWGSJSA-N 50390262 CHEMBL2070416 Mitogen-activated protein kinase 10 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2012.06.088 10.7270/Q2NZ88QX 22858099 Song, H; Lee, YS; Roh, EJ; Seo, JH; Oh, KS; Lee, BH; Han, H; Shin, KJ Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50390262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50390262&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70695135 160869345 CHEMBL2070416 ZINC84688387 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50951249 CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4cccc(c4)C(N)=O)cc3)C2=O)CC1 InChI=1S/C31H32N4O4S2/c1-33-15-17-34(18-16-33)14-3-19-38-25-12-8-24(9-13-25)35-30(37)28(41-31(35)40)20-22-6-10-26(11-7-22)39-27-5-2-4-23(21-27)29(32)36/h2,4-13,20-21H,3,14-19H2,1H3,(H2,32,36)/b28-20- CDSCWARZCDEAKD-RRAHZORUSA-N 50390259 CHEMBL2070412 Mitogen-activated protein kinase 10 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2012.06.088 10.7270/Q2NZ88QX 22858099 Song, H; Lee, YS; Roh, EJ; Seo, JH; Oh, KS; Lee, BH; Han, H; Shin, KJ Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50390259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50390259&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70697173 160869342 CHEMBL2070412 ZINC84703514 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50951250 CN1CCN(CCCOc2ccc(cc2)N2C(=S)S\C(=C/c3ccc(Oc4ccc(cc4)C(N)=O)cc3)C2=O)CC1 InChI=1S/C31H32N4O4S2/c1-33-16-18-34(19-17-33)15-2-20-38-25-13-7-24(8-14-25)35-30(37)28(41-31(35)40)21-22-3-9-26(10-4-22)39-27-11-5-23(6-12-27)29(32)36/h3-14,21H,2,15-20H2,1H3,(H2,32,36)/b28-21- LPYRYZSEMBYMFP-HFTWOUSFSA-N 50390260 CHEMBL2070413 Mitogen-activated protein kinase 10 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2012.06.088 10.7270/Q2NZ88QX 22858099 Song, H; Lee, YS; Roh, EJ; Seo, JH; Oh, KS; Lee, BH; Han, H; Shin, KJ Korea University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50390260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50390260&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70690944 160869343 CHEMBL2070413 ZINC84703519 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50944565 CC(C)C[C@H]1CN(CCN1)c1ccc(c(n1)C(=O)c1cccnc1N)C(F)(F)F InChI=1S/C20H24F3N5O/c1-12(2)10-13-11-28(9-8-25-13)16-6-5-15(20(21,22)23)17(27-16)18(29)14-4-3-7-26-19(14)24/h3-7,12-13,25H,8-11H2,1-2H3,(H2,24,26)/t13-/m0/s1 XWKJUHBICAMYNW-ZDUSSCGKSA-N 50387330 CHEMBL2046643 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2012.05.114 10.7270/Q2TM7C65 22738630 Jimenez, JM; Davis, C; Boyall, D; Fraysse, D; Knegtel, R; Settimo, L; Young, S; Bolton, C; Chiu, P; Curnock, A; Rasmussen, R; Tanner, A; Ager, I Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50387330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50387330&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24995659 160866413 CHEMBL2046643 ZINC84758312 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50982961 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1 InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ GJFCSAPFHAXMSF-UXBLZVDNSA-N 86633 JNK-IN-8 Mitogen-activated protein kinase 10 Homo sapiens 0.98 ChEMBL 10.1021/jm3003203 10.7270/Q2X92CGP 22621397 Barf, T; Kaptein, A Covalution Pharma BV http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340686 136352682 ZINC89464842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51054210 Cc1c(F)c(ccc1C(=O)N1CCOc2ccc(cc2C1)-c1ccc(N)nc1)S(C)(=O)=O InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26) LNFBAYSBVQBKFR-UHFFFAOYSA-N 50429867 CHEMBL2333365 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/jm3007933 10.7270/Q2ZC847X 23394126 Takeuchi, CS; Kim, BG; Blazey, CM; Ma, S; Johnson, HW; Anand, NK; Arcalas, A; Baik, TG; Buhr, CA; Cannoy, J; Epshteyn, S; Joshi, A; Lara, K; Lee, MS; Wang, L; Leahy, JW; Nuss, JM; Aay, N; Aoyama, R; Foster, P; Lee, J; Lehoux, I; Munagala, N; Plonowski, A; Rajan, S; Woolfrey, J; Yamaguchi, K; Lamb, P; Miller, N Exelixis Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50429867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50429867&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59604787 164158742 CHEMBL2333365 ZINC95550928 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055308 CN(C)c1nc(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 InChI=1S/C23H24N6/c1-29(2)23-18-10-16(17-11-25-26-12-17)8-9-21(18)27-22(28-23)20-14-24-13-19(20)15-6-4-3-5-7-15/h3-12,19-20,24H,13-14H2,1-2H3,(H,25,26)/t19-,20+/m0/s1 QQWMBNHFQAYFPP-VQTJNVASSA-N 50430339 CHEMBL2333879 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430339&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68621678 164159214 CHEMBL2333879 ZINC95592813 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055309 COc1ccc(cc1)[C@@H]1CN(C)C[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 InChI=1S/C23H23N5O2/c1-28-12-19(14-3-6-17(30-2)7-4-14)20(13-28)22-26-21-8-5-15(16-10-24-25-11-16)9-18(21)23(29)27-22/h3-11,19-20H,12-13H2,1-2H3,(H,24,25)(H,26,27,29)/t19-,20+/m0/s1 RINUIXSHMABIND-VQTJNVASSA-N 50430345 CHEMBL2333887 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430345&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70889576 164159220 CHEMBL2333887 ZINC95589606 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055310 NCc1ccc(cc1)C(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 InChI=1S/C26H21ClN6O2/c27-20-8-5-16(6-9-20)23(32-25(34)17-3-1-15(12-28)2-4-17)24-31-22-10-7-18(19-13-29-30-14-19)11-21(22)26(35)33-24/h1-11,13-14,23H,12,28H2,(H,29,30)(H,32,34)(H,31,33,35) WZZSMRPQWMDPQL-UHFFFAOYSA-N 50430348 CHEMBL2333884 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430348&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68622771 164159223 CHEMBL2333884 ZINC95587138 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055311 CN(C)CC(=O)NC(c1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 InChI=1S/C22H21ClN6O2/c1-29(2)12-19(30)27-20(13-3-6-16(23)7-4-13)21-26-18-8-5-14(15-10-24-25-11-15)9-17(18)22(31)28-21/h3-11,20H,12H2,1-2H3,(H,24,25)(H,27,30)(H,26,28,31) FZNNDHNMIKEKCK-UHFFFAOYSA-N 50430376 CHEMBL2333882 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430376&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68621906 164159251 CHEMBL2333882 ZINC95591771 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055312 Clc1ccc(cc1)[C@@H]1CNC[C@H]1c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 InChI=1S/C21H18ClN5O/c22-15-4-1-12(2-5-15)17-10-23-11-18(17)20-26-19-6-3-13(14-8-24-25-9-14)7-16(19)21(28)27-20/h1-9,17-18,23H,10-11H2,(H,24,25)(H,26,27,28)/t17-,18+/m0/s1 ZJEWXEAMZOTZGE-ZWKOTPCHSA-N 50430377 CHEMBL2333898 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430377&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71567755 164159252 CHEMBL2333898 ZINC95592988 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055313 COc1cc(cc2c1nc([nH]c2=O)C(N)c1cccc(Cl)c1)-c1cn[nH]c1 InChI=1S/C19H16ClN5O2/c1-27-15-7-11(12-8-22-23-9-12)6-14-17(15)24-18(25-19(14)26)16(21)10-3-2-4-13(20)5-10/h2-9,16H,21H2,1H3,(H,22,23)(H,24,25,26) GVOJSDSHNFLVIW-UHFFFAOYSA-N 50430357 CHEMBL2333896 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430357&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68624030 164159232 CHEMBL2333896 ZINC95590036 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055314 NC(c1cccc(Cl)c1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 InChI=1S/C18H14ClN5O/c19-13-3-1-2-11(6-13)16(20)17-23-15-5-4-10(12-8-21-22-9-12)7-14(15)18(25)24-17/h1-9,16H,20H2,(H,21,22)(H,23,24,25) NMVQKQZIFRBWNR-UHFFFAOYSA-N 50430359 CHEMBL2333894 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430359&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68622986 164159234 CHEMBL2333894 ZINC95586238 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055315 COc1ccc(C[C@H](N)c2nc3ccc(cc3c(=O)[nH]2)-c2cn[nH]c2)cc1 InChI=1S/C20H19N5O2/c1-27-15-5-2-12(3-6-15)8-17(21)19-24-18-7-4-13(14-10-22-23-11-14)9-16(18)20(26)25-19/h2-7,9-11,17H,8,21H2,1H3,(H,22,23)(H,24,25,26)/t17-/m0/s1 IFSJHRROANUFFS-KRWDZBQOSA-N 50430367 CHEMBL2333909 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430367&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71567482 164159242 CHEMBL2333909 ZINC95591812 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055316 COc1cc(cc2c1nc([nH]c2=O)[C@H](N)Cc1cccc(F)c1)-c1cn[nH]c1 InChI=1S/C20H18FN5O2/c1-28-17-8-12(13-9-23-24-10-13)7-15-18(17)25-19(26-20(15)27)16(22)6-11-3-2-4-14(21)5-11/h2-5,7-10,16H,6,22H2,1H3,(H,23,24)(H,25,26,27)/t16-/m1/s1 RVYJKUWZLONOCK-MRXNPFEDSA-N 50430368 CHEMBL2333908 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430368&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71567481 164159243 CHEMBL2333908 ZINC95591273 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055317 N[C@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m1/s1 BSULSXCQOXQGND-MRXNPFEDSA-N 50430370 CHEMBL2333906 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430370&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68622795 164159245 CHEMBL2333906 ZINC95587825 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055318 N[C@@H](Cc1ccc(F)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 InChI=1S/C19H16FN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1 BSULSXCQOXQGND-INIZCTEOSA-N 50430371 CHEMBL2333905 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430371&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46207461 164159246 CHEMBL2333905 ZINC95587647 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055319 N[C@@H](Cc1ccc(Cl)cc1)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 InChI=1S/C19H16ClN5O/c20-14-4-1-11(2-5-14)7-16(21)18-24-17-6-3-12(13-9-22-23-10-13)8-15(17)19(26)25-18/h1-6,8-10,16H,7,21H2,(H,22,23)(H,24,25,26)/t16-/m0/s1 XOXMVRWFWDMQLD-INIZCTEOSA-N 50430373 CHEMBL2334293 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430373&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 70889562 164159248 CHEMBL2334293 ZINC95589821 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055320 O=c1[nH]c(nc2ccc(cc12)-c1cn[nH]c1)[C@@H]1CNC[C@H]1c1ccccc1 InChI=1S/C21H19N5O/c27-21-16-8-14(15-9-23-24-10-15)6-7-19(16)25-20(26-21)18-12-22-11-17(18)13-4-2-1-3-5-13/h1-10,17-18,22H,11-12H2,(H,23,24)(H,25,26,27)/t17-,18+/m0/s1 CJDWZZDGEKRVQD-ZWKOTPCHSA-N 50430374 CHEMBL2334292 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430374&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71567350 164159249 CHEMBL2334292 ZINC95591618 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055321 COc1ccc(cc1)C(N)c1nc2ccc(cc2c(=O)[nH]1)-c1cn[nH]c1 InChI=1S/C19H17N5O2/c1-26-14-5-2-11(3-6-14)17(20)18-23-16-7-4-12(13-9-21-22-10-13)8-15(16)19(25)24-18/h2-10,17H,20H2,1H3,(H,21,22)(H,23,24,25) XEXJRQIFMJLDKP-UHFFFAOYSA-N 50430333 CHEMBL2334288 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2013.01.109 10.7270/Q2TD9ZQM 23416002 Chowdhury, S; Chen, YT; Fang, X; Grant, W; Pocas, J; Cameron, MD; Ruiz, C; Lin, L; Park, H; Schroter, T; Bannister, TD; Lograsso, PV; Feng, Y Translational Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430333&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46207463 164159208 CHEMBL2334288 ZINC95587498 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055430 Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C4)C(=O)C4CC4)n3)c2c1 InChI=1S/C30H28N6O2/c37-24-11-12-25-26(17-24)36(28(33-25)22-10-7-19-4-1-2-5-21(19)16-22)27-13-14-31-30(34-27)32-23-6-3-15-35(18-23)29(38)20-8-9-20/h1-2,4-5,7,10-14,16-17,20,23,37H,3,6,8-9,15,18H2,(H,31,32,34)/t23-/m1/s1 GQWKCVUFYCHSLR-HSZRJFAPSA-N 50430432 CHEMBL2334705 Mitogen-activated protein kinase 10 Homo sapiens 46 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430432&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1RQ 4KKH 71584212 164159307 CHEMBL2334705 ZINC95587066 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055431 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C30H28N6O2/c37-24-11-12-26-25(17-24)33-28(22-10-7-19-4-1-2-5-21(19)16-22)36(26)27-13-14-31-30(34-27)32-23-6-3-15-35(18-23)29(38)20-8-9-20/h1-2,4-5,7,10-14,16-17,20,23,37H,3,6,8-9,15,18H2,(H,31,32,34)/t23-/m1/s1 NONWPZRMZADEMH-HSZRJFAPSA-N 50430433 CHEMBL2334704 Mitogen-activated protein kinase 10 Homo sapiens 2650 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430433&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584211 164159308 CHEMBL2334704 ZINC95591267 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055432 Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(NC4CCOCC4)n3)c2c1 InChI=1S/C26H23N5O2/c32-21-7-8-22-23(16-21)31(24-9-12-27-26(30-24)28-20-10-13-33-14-11-20)25(29-22)19-6-5-17-3-1-2-4-18(17)15-19/h1-9,12,15-16,20,32H,10-11,13-14H2,(H,27,28,30) WGEXIJRKFDQJCS-UHFFFAOYSA-N 50430434 CHEMBL2334703 Mitogen-activated protein kinase 10 Homo sapiens 6000 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430434&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584210 164159309 CHEMBL2334703 ZINC95590170 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055433 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCOCC2)n1 InChI=1S/C26H23N5O2/c32-21-7-8-23-22(16-21)29-25(19-6-5-17-3-1-2-4-18(17)15-19)31(23)24-9-12-27-26(30-24)28-20-10-13-33-14-11-20/h1-9,12,15-16,20,32H,10-11,13-14H2,(H,27,28,30) XOZSAGRTIVKDDL-UHFFFAOYSA-N 50430435 CHEMBL2334702 Mitogen-activated protein kinase 10 Homo sapiens 1660 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430435&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584209 164159310 CHEMBL2334702 ZINC95587181 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055434 Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(NC4CCCCC4)n3)c2c1 InChI=1S/C27H25N5O/c33-22-12-13-23-24(17-22)32(25-14-15-28-27(31-25)29-21-8-2-1-3-9-21)26(30-23)20-11-10-18-6-4-5-7-19(18)16-20/h4-7,10-17,21,33H,1-3,8-9H2,(H,28,29,31) NDZUGGRYLOMQOG-UHFFFAOYSA-N 50430436 CHEMBL2335070 Mitogen-activated protein kinase 10 Homo sapiens 31700 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430436&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584096 164159311 CHEMBL2335070 ZINC95589230 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055435 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCCCC2)n1 InChI=1S/C27H25N5O/c33-22-12-13-24-23(17-22)30-26(20-11-10-18-6-4-5-7-19(18)16-20)32(24)25-14-15-28-27(31-25)29-21-8-2-1-3-9-21/h4-7,10-17,21,33H,1-3,8-9H2,(H,28,29,31) QMIXCBREDNAFJZ-UHFFFAOYSA-N 50430437 CHEMBL2335069 Mitogen-activated protein kinase 10 Homo sapiens 1890 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430437&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584095 164159312 CHEMBL2335069 ZINC95591766 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055436 Clc1ccc(cc1Cl)-c1nc2ccccc2n1-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H24Cl2N6O/c27-19-10-9-17(14-20(19)28)24-31-21-5-1-2-6-22(21)34(24)23-11-12-29-26(32-23)30-18-4-3-13-33(15-18)25(35)16-7-8-16/h1-2,5-6,9-12,14,16,18H,3-4,7-8,13,15H2,(H,29,30,32)/t18-/m1/s1 HHDRDYGKYXSQBA-GOSISDBHSA-N 50430438 CHEMBL2335068 Mitogen-activated protein kinase 10 Homo sapiens 7690 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430438&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584094 164159313 CHEMBL2335068 ZINC95591290 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055437 COc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C4)C(=O)C4CC4)n3)c2c1 InChI=1S/C31H30N6O2/c1-39-25-12-13-26-27(18-25)37(29(34-26)23-11-8-20-5-2-3-6-22(20)17-23)28-14-15-32-31(35-28)33-24-7-4-16-36(19-24)30(38)21-9-10-21/h2-3,5-6,8,11-15,17-18,21,24H,4,7,9-10,16,19H2,1H3,(H,32,33,35)/t24-/m1/s1 HWLPUOSBEAGBSQ-XMMPIXPASA-N 50430439 CHEMBL2335067 Mitogen-activated protein kinase 10 Homo sapiens 1170 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430439&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584093 164159314 CHEMBL2335067 ZINC95586629 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055438 COc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C31H30N6O2/c1-39-25-12-13-27-26(18-25)34-29(23-11-8-20-5-2-3-6-22(20)17-23)37(27)28-14-15-32-31(35-28)33-24-7-4-16-36(19-24)30(38)21-9-10-21/h2-3,5-6,8,11-15,17-18,21,24H,4,7,9-10,16,19H2,1H3,(H,32,33,35)/t24-/m1/s1 LNKSHWILIURXAN-XMMPIXPASA-N 50430440 CHEMBL2335066 Mitogen-activated protein kinase 10 Homo sapiens 2910 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430440&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584092 164159315 CHEMBL2335066 ZINC95591670 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055439 O=C(C1CC1)N1CCC[C@H](C1)Nc1nccc(n1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C30H28N6O/c37-29(21-12-13-21)35-17-5-8-24(19-35)32-30-31-16-15-27(34-30)36-26-10-4-3-9-25(26)33-28(36)23-14-11-20-6-1-2-7-22(20)18-23/h1-4,6-7,9-11,14-16,18,21,24H,5,8,12-13,17,19H2,(H,31,32,34)/t24-/m1/s1 PGKIIPYIXYUNOE-XMMPIXPASA-N 50430441 CHEMBL2335065 Mitogen-activated protein kinase 10 Homo sapiens 1930 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430441&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583990 164159316 CHEMBL2335065 ZINC95589236 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055440 C1CNC[C@@H](C1)Nc1nccc(n1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C26H24N6/c1-2-7-19-16-20(12-11-18(19)6-1)25-30-22-9-3-4-10-23(22)32(25)24-13-15-28-26(31-24)29-21-8-5-14-27-17-21/h1-4,6-7,9-13,15-16,21,27H,5,8,14,17H2,(H,28,29,31)/t21-/m1/s1 QTZBCHXGQNTVCK-OAQYLSRUSA-N 50430442 CHEMBL2335064 Mitogen-activated protein kinase 10 Homo sapiens 2980 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430442&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71717015 164159317 CHEMBL2335064 ZINC95592420 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055441 Clc1ccc(cc1Cl)-c1nc2ccccc2n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C22H19Cl2N5O/c23-16-6-5-14(13-17(16)24)21-27-18-3-1-2-4-19(18)29(21)20-7-10-25-22(28-20)26-15-8-11-30-12-9-15/h1-7,10,13,15H,8-9,11-12H2,(H,25,26,28) NUBHHICZZNJVSS-UHFFFAOYSA-N 50430443 CHEMBL2334723 Mitogen-activated protein kinase 10 Homo sapiens 21800 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430443&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583989 164159318 CHEMBL2334723 ZINC95589249 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055442 COc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(NC4CCCCC4)n3)c2c1 InChI=1S/C28H27N5O/c1-34-23-13-14-24-25(18-23)33(26-15-16-29-28(32-26)30-22-9-3-2-4-10-22)27(31-24)21-12-11-19-7-5-6-8-20(19)17-21/h5-8,11-18,22H,2-4,9-10H2,1H3,(H,29,30,32) QJPWQJPSTPILRY-UHFFFAOYSA-N 50430444 CHEMBL2334722 Mitogen-activated protein kinase 10 Homo sapiens 1770 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430444&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583988 164159319 CHEMBL2334722 ZINC95586645 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055443 COc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCCCC2)n1 InChI=1S/C28H27N5O/c1-34-23-13-14-25-24(18-23)31-27(21-12-11-19-7-5-6-8-20(19)17-21)33(25)26-15-16-29-28(32-26)30-22-9-3-2-4-10-22/h5-8,11-18,22H,2-4,9-10H2,1H3,(H,29,30,32) BLYQNHCDMISTOE-UHFFFAOYSA-N 50430445 CHEMBL2334721 Mitogen-activated protein kinase 10 Homo sapiens 743 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430445&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583987 164159320 CHEMBL2334721 ZINC95586467 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055444 C1CC(CCO1)Nc1nccc(n1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C26H23N5O/c1-2-6-19-17-20(10-9-18(19)5-1)25-29-22-7-3-4-8-23(22)31(25)24-11-14-27-26(30-24)28-21-12-15-32-16-13-21/h1-11,14,17,21H,12-13,15-16H2,(H,27,28,30) PFISUKKTQWGHME-UHFFFAOYSA-N 50430446 CHEMBL2334720 Mitogen-activated protein kinase 10 Homo sapiens 2330 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430446&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583986 164159321 CHEMBL2334720 ZINC95586173 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055445 C1CCC(CC1)Nc1nccc(n1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C27H25N5/c1-2-10-22(11-3-1)29-27-28-17-16-25(31-27)32-24-13-7-6-12-23(24)30-26(32)21-15-14-19-8-4-5-9-20(19)18-21/h4-9,12-18,22H,1-3,10-11H2,(H,28,29,31) YHHANOMLSREBSQ-UHFFFAOYSA-N 50430447 CHEMBL2334719 Mitogen-activated protein kinase 10 Homo sapiens 1750 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430447&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583889 164159322 CHEMBL2334719 ZINC95586463 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055446 Oc1ccc2n(c(nc2c1)-c1ccc(Cl)c(Cl)c1)-c1ccnc(NC2CCCCC2)c1 InChI=1S/C24H22Cl2N4O/c25-19-8-6-15(12-20(19)26)24-29-21-14-18(31)7-9-22(21)30(24)17-10-11-27-23(13-17)28-16-4-2-1-3-5-16/h6-14,16,31H,1-5H2,(H,27,28) NITZJWDXCWRXAP-UHFFFAOYSA-N 50430448 CHEMBL2334718 Mitogen-activated protein kinase 10 Homo sapiens 13800 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430448&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583888 164159323 CHEMBL2334718 ZINC95589012 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055447 C[C@H](O)CNc1cc(ccn1)-n1c(nc2ccccc12)-c1cccc(O)c1 InChI=1S/C21H20N4O2/c1-14(26)13-23-20-12-16(9-10-22-20)25-19-8-3-2-7-18(19)24-21(25)15-5-4-6-17(27)11-15/h2-12,14,26-27H,13H2,1H3,(H,22,23)/t14-/m0/s1 AEVXBTIKHBFACQ-AWEZNQCLSA-N 50430449 CHEMBL2334717 Mitogen-activated protein kinase 10 Homo sapiens 19100 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430449&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583887 164159324 CHEMBL2334717 ZINC95587611 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055448 Oc1cccc(c1)-c1nc2ccccc2n1-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)c1 InChI=1S/C27H27N5O2/c33-22-7-3-5-19(15-22)26-30-23-8-1-2-9-24(23)32(26)21-12-13-28-25(16-21)29-20-6-4-14-31(17-20)27(34)18-10-11-18/h1-3,5,7-9,12-13,15-16,18,20,33H,4,6,10-11,14,17H2,(H,28,29)/t20-/m1/s1 CQERWDWSCNZVRB-HXUWFJFHSA-N 50430450 CHEMBL2334716 Mitogen-activated protein kinase 10 Homo sapiens 2640 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430450&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583886 164159325 CHEMBL2334716 ZINC95586236 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055449 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)c1 InChI=1S/C31H29N5O2/c37-26-11-12-28-27(18-26)34-30(23-10-7-20-4-1-2-5-22(20)16-23)36(28)25-13-14-32-29(17-25)33-24-6-3-15-35(19-24)31(38)21-8-9-21/h1-2,4-5,7,10-14,16-18,21,24,37H,3,6,8-9,15,19H2,(H,32,33)/t24-/m1/s1 ROGYDKSLJQXHRH-XMMPIXPASA-N 50430451 CHEMBL2334715 Mitogen-activated protein kinase 10 Homo sapiens 27700 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430451&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583885 164159326 CHEMBL2334715 ZINC95587636 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055450 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(N[C@@H]2CCCNC2)c1 InChI=1S/C27H25N5O/c33-23-9-10-25-24(16-23)31-27(20-8-7-18-4-1-2-5-19(18)14-20)32(25)22-11-13-29-26(15-22)30-21-6-3-12-28-17-21/h1-2,4-5,7-11,13-16,21,28,33H,3,6,12,17H2,(H,29,30)/t21-/m1/s1 PERLLRDOEGMSEP-OAQYLSRUSA-N 50430452 CHEMBL2334714 Mitogen-activated protein kinase 10 Homo sapiens 6050 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430452&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583884 164159327 CHEMBL2334714 ZINC95592871 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055451 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCOCC2)c1 InChI=1S/C27H24N4O2/c32-23-7-8-25-24(17-23)30-27(20-6-5-18-3-1-2-4-19(18)15-20)31(25)22-9-12-28-26(16-22)29-21-10-13-33-14-11-21/h1-9,12,15-17,21,32H,10-11,13-14H2,(H,28,29) KVGMNWJSHWIYDZ-UHFFFAOYSA-N 50430453 CHEMBL2334713 Mitogen-activated protein kinase 10 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430453&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583771 164159328 CHEMBL2334713 ZINC95591552 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055452 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCCCC2)c1 InChI=1S/C28H26N4O/c33-24-12-13-26-25(18-24)31-28(21-11-10-19-6-4-5-7-20(19)16-21)32(26)23-14-15-29-27(17-23)30-22-8-2-1-3-9-22/h4-7,10-18,22,33H,1-3,8-9H2,(H,29,30) HSZNPLMQJHQVIP-UHFFFAOYSA-N 50430454 CHEMBL2334712 Mitogen-activated protein kinase 10 Homo sapiens 24500 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430454&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583770 164159329 CHEMBL2334712 ZINC95587691 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055453 O=C(C1CC1)N1CCC[C@H](C1)Nc1cc(ccn1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C31H29N5O/c37-31(22-12-13-22)35-17-5-8-25(20-35)33-29-19-26(15-16-32-29)36-28-10-4-3-9-27(28)34-30(36)24-14-11-21-6-1-2-7-23(21)18-24/h1-4,6-7,9-11,14-16,18-19,22,25H,5,8,12-13,17,20H2,(H,32,33)/t25-/m1/s1 RTDQAEAZHTXYSM-RUZDIDTESA-N 50430455 CHEMBL2334711 Mitogen-activated protein kinase 10 Homo sapiens 10700 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430455&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583769 164159330 CHEMBL2334711 ZINC95588909 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055454 COc1ccc2n(c(nc2c1)-c1ccc(Cl)c(Cl)c1)-c1ccnc(NC2CCCCC2)c1 InChI=1S/C25H24Cl2N4O/c1-32-19-8-10-23-22(15-19)30-25(16-7-9-20(26)21(27)13-16)31(23)18-11-12-28-24(14-18)29-17-5-3-2-4-6-17/h7-15,17H,2-6H2,1H3,(H,28,29) VCPZSBQOFFKKEK-UHFFFAOYSA-N 50430456 CHEMBL2334710 Mitogen-activated protein kinase 10 Homo sapiens 18100 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430456&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583768 164159331 CHEMBL2334710 ZINC95591722 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055455 COc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCCCC2)c1 InChI=1S/C29H28N4O/c1-34-25-13-14-27-26(19-25)32-29(22-12-11-20-7-5-6-8-21(20)17-22)33(27)24-15-16-30-28(18-24)31-23-9-3-2-4-10-23/h5-8,11-19,23H,2-4,9-10H2,1H3,(H,30,31) FYJJXSXICFMGQY-UHFFFAOYSA-N 50430457 CHEMBL2334709 Mitogen-activated protein kinase 10 Homo sapiens 176000 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430457&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71718247 164159332 CHEMBL2334709 ZINC95591064 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055456 C[C@H](O)CNc1cc(ccn1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C25H22N4O/c1-17(30)16-27-24-15-21(12-13-26-24)29-23-9-5-4-8-22(23)28-25(29)20-11-10-18-6-2-3-7-19(18)14-20/h2-15,17,30H,16H2,1H3,(H,26,27)/t17-/m0/s1 VLBRXKUTMFGCOE-KRWDZBQOSA-N 50430458 CHEMBL2334708 Mitogen-activated protein kinase 10 Homo sapiens 12700 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430458&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583767 164159333 CHEMBL2334708 ZINC95592497 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055457 C1CC(CCO1)Nc1cc(ccn1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C27H24N4O/c1-2-6-20-17-21(10-9-19(20)5-1)27-30-24-7-3-4-8-25(24)31(27)23-11-14-28-26(18-23)29-22-12-15-32-16-13-22/h1-11,14,17-18,22H,12-13,15-16H2,(H,28,29) JZQQOKUENCAWLR-UHFFFAOYSA-N 50430459 CHEMBL2334707 Mitogen-activated protein kinase 10 Homo sapiens 4650 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430459&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583766 164159334 CHEMBL2334707 ZINC95587918 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51055458 C1CCC(CC1)Nc1cc(ccn1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C28H26N4/c1-2-10-23(11-3-1)30-27-19-24(16-17-29-27)32-26-13-7-6-12-25(26)31-28(32)22-15-14-20-8-4-5-9-21(20)18-22/h4-9,12-19,23H,1-3,10-11H2,(H,29,30) IGWWQFBSMMAYKV-UHFFFAOYSA-N 50430460 CHEMBL2334706 Mitogen-activated protein kinase 10 Homo sapiens 5260 ChEMBL 10.1016/j.bmcl.2013.01.082 10.7270/Q2F76DXD 23416008 Kim, MH; Ryu, JS; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430460&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583660 164159335 CHEMBL2334706 ZINC95586682 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004190 Brc1ccccc1CC(=O)Nc1sc2CCCCc2c1C#N InChI=1S/C17H15BrN2OS/c18-14-7-3-1-5-11(14)9-16(21)20-17-13(10-19)12-6-2-4-8-15(12)22-17/h1,3,5,7H,2,4,6,8-9H2,(H,20,21) TZCIQCNJFXCYEF-UHFFFAOYSA-N 50411404 CHEMBL234840 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411404&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431825 163360428 CHEMBL234840 ZINC28821918 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004193 O=C(Nc1sc2N(CCCc2c1C#N)C(=O)c1ccn[nH]1)c1cccc2ccccc12 InChI=1S/C23H17N5O2S/c24-13-18-17-9-4-12-28(22(30)19-10-11-25-27-19)23(17)31-21(18)26-20(29)16-8-3-6-14-5-1-2-7-15(14)16/h1-3,5-8,10-11H,4,9,12H2,(H,25,27)(H,26,29) OHRSFHHDQNOOGV-UHFFFAOYSA-N 50411407 CHEMBL232610 Mitogen-activated protein kinase 10 Homo sapiens 251.19 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411407&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431831 163360431 CHEMBL232610 ZINC28821926 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004202 O=C(Nc1sc2CCCCc2c1C#N)c1ccsc1 InChI=1S/C14H12N2OS2/c15-7-11-10-3-1-2-4-12(10)19-14(11)16-13(17)9-5-6-18-8-9/h5-6,8H,1-4H2,(H,16,17) ZTTGYKSKKUNFSG-UHFFFAOYSA-N 50411411 CHEMBL397356 Mitogen-activated protein kinase 10 Homo sapiens 630.96 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411411&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431823 163360435 CHEMBL397356 ZINC28821913 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004203 O=C(NC1CCCC1)Nc1sc2CCCCc2c1C#N InChI=1S/C15H19N3OS/c16-9-12-11-7-3-4-8-13(11)20-14(12)18-15(19)17-10-5-1-2-6-10/h10H,1-8H2,(H2,17,18,19) OLXKHUCPMYCFSB-UHFFFAOYSA-N 50411412 CHEMBL391198 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411412&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431828 163360436 CHEMBL391198 ZINC28821921 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004206 O=C(CN1CCOCC1)Nc1sc2CCCCc2c1C#N InChI=1S/C15H19N3O2S/c16-9-12-11-3-1-2-4-13(11)21-15(12)17-14(19)10-18-5-7-20-8-6-18/h1-8,10H2,(H,17,19) CWJNUEJVFIPZQN-UHFFFAOYSA-N 50411409 CHEMBL232405 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411409&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 826287 163360433 CHEMBL232405 ZINC19287961 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004210 O=C(Nc1sc2CCCCc2c1C#N)c1cccc2ccccc12 InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2,5-8,10H,3-4,9,11H2,(H,22,23) WQGDQGAFSDMBLA-UHFFFAOYSA-N 86638 Name not given Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86638&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 766949 136352687 ZINC00244029 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004212 O=C(Nc1sc2CCCCc2c1C#N)C1CCCCC1 InChI=1S/C16H20N2OS/c17-10-13-12-8-4-5-9-14(12)20-16(13)18-15(19)11-6-2-1-3-7-11/h11H,1-9H2,(H,18,19) HABPUSRRADTLAQ-UHFFFAOYSA-N 50365994 CHEMBL396627 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50365994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50365994&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 847353 136970056 CHEMBL396627 ZINC00380936 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004218 Brc1ccccc1C(=O)Nc1sc2CCCCc2c1C#N InChI=1S/C16H13BrN2OS/c17-13-7-3-1-6-11(13)15(20)19-16-12(9-18)10-5-2-4-8-14(10)21-16/h1,3,6-7H,2,4-5,8H2,(H,19,20) UTVJDJGOECBNNT-UHFFFAOYSA-N 50411416 CHEMBL234839 Mitogen-activated protein kinase 10 Homo sapiens 3162.28 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411416&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1100747 163360440 CHEMBL234839 ZINC00825446 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004220 O=C(Nc1sc2CCCCc2c1C#N)c1ccccc1 InChI=1S/C16H14N2OS/c17-10-13-12-8-4-5-9-14(12)20-16(13)18-15(19)11-6-2-1-3-7-11/h1-3,6-7H,4-5,8-9H2,(H,18,19) OKFHWMLGUMHKFC-UHFFFAOYSA-N 50241256 CHEMBL233000::N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)benzamide Mitogen-activated protein kinase 10 Homo sapiens 1584.89 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241256&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 290221 104098682 CHEMBL233000 ZINC00135906 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004224 Fc1ccccc1C(=O)Nc1sc2CCCCc2c1C#N InChI=1S/C16H13FN2OS/c17-13-7-3-1-6-11(13)15(20)19-16-12(9-18)10-5-2-4-8-14(10)21-16/h1,3,6-7H,2,4-5,8H2,(H,19,20) YVYPYORTKAIUGJ-UHFFFAOYSA-N 50411413 CHEMBL234838 Mitogen-activated protein kinase 10 Homo sapiens 398.11 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411413&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 738 2O2U 766948 163360437 CHEMBL234838 DB07217 ZINC00244028 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004226 Fc1ccc(cc1)C(=O)Nc1sc2CCCCc2c1C#N InChI=1S/C16H13FN2OS/c17-11-7-5-10(6-8-11)15(20)19-16-13(9-18)12-3-1-2-4-14(12)21-16/h5-8H,1-4H2,(H,19,20) ONINFKOEYCCERZ-UHFFFAOYSA-N 50411414 CHEMBL397570::SB-347804 Mitogen-activated protein kinase 10 Homo sapiens 3162.28 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411414&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 579429 163360438 CHEMBL397570 ZINC00354158 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004230 O=S(=O)(Nc1sc2CCCCc2c1C#N)c1cccc2ccccc12 InChI=1S/C19H16N2O2S2/c20-12-16-15-9-3-4-10-17(15)24-19(16)21-25(22,23)18-11-5-7-13-6-1-2-8-14(13)18/h1-2,5-8,11,21H,3-4,9-10H2 UYFKQTDDSFYPTP-UHFFFAOYSA-N 50411403 CHEMBL232406 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411403&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431826 163360427 CHEMBL232406 ZINC28821919 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004232 O=C(Nc1sc2CCCCc2c1C#N)Nc1cccc2ccccc12 InChI=1S/C20H17N3OS/c21-12-16-15-9-3-4-11-18(15)25-19(16)23-20(24)22-17-10-5-7-13-6-1-2-8-14(13)17/h1-2,5-8,10H,3-4,9,11H2,(H2,22,23,24) PICUWCVSFHKLSC-UHFFFAOYSA-N 50411418 CHEMBL234687 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411418&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431827 163360442 CHEMBL234687 ZINC28821920 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004238 Fc1ccc(C(=O)Nc2sc3CCCCc3c2C#N)c2ccccc12 InChI=1S/C20H15FN2OS/c21-17-10-9-15(12-5-1-2-6-13(12)17)19(24)23-20-16(11-22)14-7-3-4-8-18(14)25-20/h1-2,5-6,9-10H,3-4,7-8H2,(H,23,24) WTBQHGKQMCKGNX-UHFFFAOYSA-N 50411419 CHEMBL233002::SB-814597 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411419&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431824 163360443 CHEMBL233002 ZINC28821917 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004240 Cc1cccc(c1)S(=O)(=O)Nc1sc2CCCCc2c1C#N InChI=1S/C16H16N2O2S2/c1-11-5-4-6-12(9-11)22(19,20)18-16-14(10-17)13-7-2-3-8-15(13)21-16/h4-6,9,18H,2-3,7-8H2,1H3 WZBDFWIGCTVBBW-UHFFFAOYSA-N 50411420 CHEMBL232598 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411420&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 15680125 163360444 CHEMBL232598 ZINC28821922 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004241 CS(=O)(=O)c1ccc(CN2CCCc3c2sc(NC(=O)c2cccc4ccccc24)c3C#N)cc1 InChI=1S/C27H23N3O3S2/c1-35(32,33)20-13-11-18(12-14-20)17-30-15-5-10-23-24(16-28)26(34-27(23)30)29-25(31)22-9-4-7-19-6-2-3-8-21(19)22/h2-4,6-9,11-14H,5,10,15,17H2,1H3,(H,29,31) KEHNOKLRUPVAGW-UHFFFAOYSA-N 50411408 CHEMBL391655 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411408&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431832 163360432 CHEMBL391655 ZINC28821927 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004248 O=C(Cc1ccccc1)Nc1sc2CCCCc2c1C#N InChI=1S/C17H16N2OS/c18-11-14-13-8-4-5-9-15(13)21-17(14)19-16(20)10-12-6-2-1-3-7-12/h1-3,6-7H,4-5,8-10H2,(H,19,20) XAECXGNGYGUEJS-UHFFFAOYSA-N 50365995 CHEMBL397167 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50365995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50365995&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 684674 136970057 CHEMBL397167 ZINC00051357 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004250 O=C(Nc1sc2N(Cc3cccnc3)CCCc2c1C#N)c1cccc2ccccc12 InChI=1S/C25H20N4OS/c26-14-22-21-11-5-13-29(16-17-6-4-12-27-15-17)25(21)31-24(22)28-23(30)20-10-3-8-18-7-1-2-9-19(18)20/h1-4,6-10,12,15H,5,11,13,16H2,(H,28,30) KVMVRGICOLXABJ-UHFFFAOYSA-N 50411417 CHEMBL391656 Mitogen-activated protein kinase 10 Homo sapiens 501.19 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411417&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431833 163360441 CHEMBL391656 ZINC28821928 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004251 O=C(Nc1sc2CN(CCc2c1C#N)S(=O)(=O)c1ccccc1)c1cccc2ccccc12 InChI=1S/C25H19N3O3S2/c26-15-22-20-13-14-28(33(30,31)18-9-2-1-3-10-18)16-23(20)32-25(22)27-24(29)21-12-6-8-17-7-4-5-11-19(17)21/h1-12H,13-14,16H2,(H,27,29) HEOQTGAUGMPJQO-UHFFFAOYSA-N 50411410 CHEMBL398601 Mitogen-activated protein kinase 10 Homo sapiens 3162.28 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411410&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431830 163360434 CHEMBL398601 ZINC28821924 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004264 CN(C)CC(=O)N1CCc2c(C1)sc(NC(=O)c1cccc3ccccc13)c2C#N InChI=1S/C23H22N4O2S/c1-26(2)14-21(28)27-11-10-17-19(12-24)23(30-20(17)13-27)25-22(29)18-9-5-7-15-6-3-4-8-16(15)18/h3-9H,10-11,13-14H2,1-2H3,(H,25,29) LSFGNMVMIPYOAV-UHFFFAOYSA-N 50411421 CHEMBL232600 Mitogen-activated protein kinase 10 Homo sapiens 2511.89 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411421&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431829 163360445 CHEMBL232600 ZINC28821923 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004272 O=C(Nc1sc2N(CCCc2c1C#N)S(=O)(=O)c1ccccc1)c1cccc2ccccc12 InChI=1S/C25H19N3O3S2/c26-16-22-21-14-7-15-28(33(30,31)18-10-2-1-3-11-18)25(21)32-24(22)27-23(29)20-13-6-9-17-8-4-5-12-19(17)20/h1-6,8-13H,7,14-15H2,(H,27,29) WUNOOYDRKZKVLA-UHFFFAOYSA-N 50411405 CHEMBL233794 Mitogen-activated protein kinase 10 Homo sapiens 1584.89 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411405&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44431834 163360429 CHEMBL233794 ZINC28821929 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004273 O=C(Nc1sc2N(CCCc2c1C#N)C(=O)C1CC1)c1cccc2ccccc12 InChI=1S/C23H19N3O2S/c24-13-19-18-9-4-12-26(22(28)15-10-11-15)23(18)29-21(19)25-20(27)17-8-3-6-14-5-1-2-7-16(14)17/h1-3,5-8,15H,4,9-12H2,(H,25,27) KTBZRPANEUUZDW-UHFFFAOYSA-N 50411406 CHEMBL232601 Mitogen-activated protein kinase 10 Homo sapiens 251.19 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411406&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 16664858 163360430 CHEMBL232601 ZINC28821925 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51004278 O=C(CCN1CCCCC1)N1CCc2c(C1)sc(NC(=O)c1cccc3ccccc13)c2C#N InChI=1S/C27H28N4O2S/c28-17-23-21-11-16-31(25(32)12-15-30-13-4-1-5-14-30)18-24(21)34-27(23)29-26(33)22-10-6-8-19-7-2-3-9-20(19)22/h2-3,6-10H,1,4-5,11-16,18H2,(H,29,33) PRZGSWGFNRYBIP-UHFFFAOYSA-N 50411415 CHEMBL232599 Mitogen-activated protein kinase 10 Homo sapiens 3162.28 ChEMBL 10.1016/j.bmcl.2006.12.003 10.7270/Q2TB1840 17194588 Angell, RM; Atkinson, FL; Brown, MJ; Chuang, TT; Christopher, JA; Cichy-Knight, M; Dunn, AK; Hightower, KE; Malkakorpi, S; Musgrave, JR; Neu, M; Rowland, P; Shea, RL; Smith, JL; Somers, DO; Thomas, SA; Thompson, G; Wang, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50411415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50411415&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search C0M 2O0U 15991561 163360439 CHEMBL232599 ZINC16052262 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014733 COc1cc2CCN=C(c3ccccc3)c2cc1OC InChI=1S/C17H17NO2/c1-19-15-10-13-8-9-18-17(12-6-4-3-5-7-12)14(13)11-16(15)20-2/h3-7,10-11H,8-9H2,1-2H3 WGTCMJBJRPKENJ-UHFFFAOYSA-N 50415602 CHEMBL1086783 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415602&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 622378 163364626 CHEMBL1086783 ZINC00150420 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014734 COc1cccc(c1)C1=NCCc2cc(OC)c(OC)cc12 InChI=1S/C18H19NO3/c1-20-14-6-4-5-13(9-14)18-15-11-17(22-3)16(21-2)10-12(15)7-8-19-18/h4-6,9-11H,7-8H2,1-3H3 OGVNHOMELRLNEM-UHFFFAOYSA-N 50415603 CHEMBL1086785 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415603&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 626628 163364627 CHEMBL1086785 ZINC32273404 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014735 COc1cc2C(=NCCc2cc1Cl)c1cccc(Cl)c1 InChI=1S/C16H13Cl2NO/c1-20-15-9-13-10(8-14(15)18)5-6-19-16(13)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3 ZSBXRUMZMZJCRU-UHFFFAOYSA-N 50415604 CHEMBL1077116 Mitogen-activated protein kinase 10 Homo sapiens 12589.25 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415604&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881341 163364628 CHEMBL1077116 ZINC49049289 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014736 Clc1cccc(c1)C1=NCCc2ccccc12 InChI=1S/C15H12ClN/c16-13-6-3-5-12(10-13)15-14-7-2-1-4-11(14)8-9-17-15/h1-7,10H,8-9H2 JIDXPKFIJYLMNM-UHFFFAOYSA-N 50415605 CHEMBL1084663 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415605&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10847715 163364629 CHEMBL1084663 ZINC34522252 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014737 COc1cc2CCN=C(c3cccc(F)c3)c2cc1Cl InChI=1S/C16H13ClFNO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)17)11-3-2-4-12(18)7-11/h2-4,7-9H,5-6H2,1H3 OOCXZXSRHKUOAF-UHFFFAOYSA-N 50415606 CHEMBL1084664 Mitogen-activated protein kinase 10 Homo sapiens 3981.07 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415606&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881342 163364630 CHEMBL1084664 ZINC49046840 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014738 COc1cc2C(=NCCc2cc1Cl)c1cccc(F)c1 InChI=1S/C16H13ClFNO/c1-20-15-9-13-10(8-14(15)17)5-6-19-16(13)11-3-2-4-12(18)7-11/h2-4,7-9H,5-6H2,1H3 YYLOQKSTDHDLAJ-UHFFFAOYSA-N 50415607 CHEMBL1082865 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415607&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881343 163364631 CHEMBL1082865 ZINC49037348 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014739 COc1cc2CCN=C(c3ccc(F)cc3)c2cc1Cl InChI=1S/C16H13ClFNO/c1-20-15-8-11-6-7-19-16(13(11)9-14(15)17)10-2-4-12(18)5-3-10/h2-5,8-9H,6-7H2,1H3 AUPLHCATCBBVFA-UHFFFAOYSA-N 50415608 CHEMBL1082866 Mitogen-activated protein kinase 10 Homo sapiens 5011.87 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415608&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881344 163364632 CHEMBL1082866 ZINC49037350 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014740 COc1cc2C(=NCCc2cc1Cl)c1ccc(F)cc1 InChI=1S/C16H13ClFNO/c1-20-15-9-13-11(8-14(15)17)6-7-19-16(13)10-2-4-12(18)5-3-10/h2-5,8-9H,6-7H2,1H3 GEIOOMRKGSMHML-UHFFFAOYSA-N 50415609 CHEMBL1082867 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415609&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881345 163364633 CHEMBL1082867 ZINC49037352 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014751 COc1cc2CCN=C(c3cccc(Br)c3)c2cc1Cl InChI=1S/C16H13BrClNO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3 IKGXHBGCVQTQBH-UHFFFAOYSA-N 50415612 CHEMBL1083185 Mitogen-activated protein kinase 10 Homo sapiens 398.11 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415612&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search SNB 2WAJ 25203945 163364636 CHEMBL1083185 DB08555 ZINC38996446 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014752 COc1cc2C(=NCCc2cc1Cl)c1cccc(Br)c1 InChI=1S/C16H13BrClNO/c1-20-15-9-13-10(8-14(15)18)5-6-19-16(13)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3 NLBDGEQENFDEJW-UHFFFAOYSA-N 50415613 CHEMBL1077137 Mitogen-activated protein kinase 10 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415613&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881351 163364637 CHEMBL1077137 ZINC49049897 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014753 COc1cc2CCN=C(c3ccc4ccccc4c3)c2cc1Cl InChI=1S/C20H16ClNO/c1-23-19-11-15-8-9-22-20(17(15)12-18(19)21)16-7-6-13-4-2-3-5-14(13)10-16/h2-7,10-12H,8-9H2,1H3 ZXKUMSSEASFKPO-UHFFFAOYSA-N 50415614 CHEMBL1088053 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415614&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881352 163364638 CHEMBL1088053 ZINC49052089 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014754 COc1cc2C(=NCCc2cc1Cl)c1ccc2ccccc2c1 InChI=1S/C20H16ClNO/c1-23-19-12-17-15(11-18(19)21)8-9-22-20(17)16-7-6-13-4-2-3-5-14(13)10-16/h2-7,10-12H,8-9H2,1H3 XWTKUJNOZRLLRU-UHFFFAOYSA-N 50415615 CHEMBL1087420 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415615&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881353 163364639 CHEMBL1087420 ZINC49054156 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014755 COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3 QLDFAHVPALXKAU-UHFFFAOYSA-N 50415616 CHEMBL1087421 Mitogen-activated protein kinase 10 Homo sapiens 316.23 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415616&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44138048 163364640 CHEMBL1087421 ZINC49054159 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014756 COc1cc2C(=NCCc2cc1Cl)c1ccc(Cl)c(Cl)c1 InChI=1S/C16H12Cl3NO/c1-21-15-8-11-9(6-14(15)19)4-5-20-16(11)10-2-3-12(17)13(18)7-10/h2-3,6-8H,4-5H2,1H3 PKGYSFSWUWIJMO-UHFFFAOYSA-N 50415617 CHEMBL1087544 Mitogen-activated protein kinase 10 Homo sapiens 15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415617&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881354 163364641 CHEMBL1087544 ZINC49053006 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014757 COc1cc2CCN=C(c3ccccc3)c2cc1Cl InChI=1S/C16H14ClNO/c1-19-15-9-12-7-8-18-16(13(12)10-14(15)17)11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3 FZUVNKQQGUOJPW-UHFFFAOYSA-N 50415618 CHEMBL1077132 Mitogen-activated protein kinase 10 Homo sapiens 6309.57 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415618&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881355 163364642 CHEMBL1077132 ZINC49051887 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014758 COc1cc2C(=NCCc2cc1Cl)c1ccccc1 InChI=1S/C16H14ClNO/c1-19-15-10-13-12(9-14(15)17)7-8-18-16(13)11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3 LCJHNYJXBBYZIT-UHFFFAOYSA-N 50415619 CHEMBL1088632 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415619&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 14198571 163364643 CHEMBL1088632 ZINC49068486 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014759 COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3 FRZUSJCWOONEQS-UHFFFAOYSA-N 50415620 CHEMBL1088633 Mitogen-activated protein kinase 10 Homo sapiens 251.19 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415620&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44138049 163364644 CHEMBL1088633 ZINC49067053 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014760 COc1cc2CCN=C(c3cccc(C)c3)c2cc1Cl InChI=1S/C17H16ClNO/c1-11-4-3-5-13(8-11)17-14-10-15(18)16(20-2)9-12(14)6-7-19-17/h3-5,8-10H,6-7H2,1-2H3 RXAISPDILWRCME-UHFFFAOYSA-N 50415621 CHEMBL1088634 Mitogen-activated protein kinase 10 Homo sapiens 1995.26 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415621&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881358 163364645 CHEMBL1088634 ZINC49067207 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014761 COc1cc2CCN=C(Cc3ccccc3)c2cc1Cl InChI=1S/C17H16ClNO/c1-20-17-10-13-7-8-19-16(14(13)11-15(17)18)9-12-5-3-2-4-6-12/h2-6,10-11H,7-9H2,1H3 QJVRXBBYOXGLKO-UHFFFAOYSA-N 50415622 CHEMBL1087694 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415622&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881360 163364646 CHEMBL1087694 ZINC49054193 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014762 CCC1=NCCc2cc(OC)c(Cl)cc12 InChI=1S/C12H14ClNO/c1-3-11-9-7-10(13)12(15-2)6-8(9)4-5-14-11/h6-7H,3-5H2,1-2H3 PMRDGUOYVKCWKU-UHFFFAOYSA-N 50415623 CHEMBL1087810 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415623&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881361 163364647 CHEMBL1087810 ZINC49052509 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014774 COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3 QLDFAHVPALXKAU-UHFFFAOYSA-N 50415616 CHEMBL1087421 Mitogen-activated protein kinase 10 Homo sapiens 50.12 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415616&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44138048 163364640 CHEMBL1087421 ZINC49054159 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014777 COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3 FRZUSJCWOONEQS-UHFFFAOYSA-N 50415620 CHEMBL1088633 Mitogen-activated protein kinase 10 Homo sapiens 125.89 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415620&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44138049 163364644 CHEMBL1088633 ZINC49067053 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014783 COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1OC InChI=1S/C17H16ClNO2/c1-20-15-9-11-6-7-19-17(14(11)10-16(15)21-2)12-4-3-5-13(18)8-12/h3-5,8-10H,6-7H2,1-2H3 QEQAPBVOPDXXRB-UHFFFAOYSA-N 50415625 CHEMBL1077118 Mitogen-activated protein kinase 10 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415625&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2823738 163364649 CHEMBL1077118 ZINC00171669 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014786 Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NC1CCNCC1 InChI=1S/C25H24ClN5O/c26-21-6-1-2-7-22(21)28-19-8-9-20-23(15-19)30-31-24(20)16-4-3-5-17(14-16)25(32)29-18-10-12-27-13-11-18/h1-9,14-15,18,27-28H,10-13H2,(H,29,32)(H,30,31) VKTAENBLRPMXKK-UHFFFAOYSA-N 50172920 3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(piperidin-4-yl)benzamide::3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-N-piperidin-4-yl-benzamide::CHEMBL194806 Mitogen-activated protein kinase 10 Homo sapiens 1.26 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50172920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50172920&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44404813 104058956 CHEMBL194806 ZINC28525785 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014787 O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)C1CCOC1 InChI=1S/C21H20N4O2/c26-21(17-8-11-27-14-17)25-20-13-16(7-10-23-20)15-6-9-22-19(12-15)24-18-4-2-1-3-5-18/h1-7,9-10,12-13,17H,8,11,14H2,(H,22,24)(H,23,25,26) YZIQMIAREGGHFQ-UHFFFAOYSA-N 50178832 CHEMBL203535::N-(2'-(phenylamino)-4,4'-bipyridin-2-yl)tetrahydrofuran-3-carboxamide::N-(4-(2-(phenylamino)pyridin-4-yl)pyridin-2-yl)-tetrahydrofuran-3-carboxamide Mitogen-activated protein kinase 10 Homo sapiens 6.31 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178832&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10247954 104064105 CHEMBL203535 ZINC28571781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014790 COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1OC InChI=1S/C17H15Cl2NO2/c1-21-15-8-10-5-6-20-17(12(10)9-16(15)22-2)11-3-4-13(18)14(19)7-11/h3-4,7-9H,5-6H2,1-2H3 STEAFPVOWXZUDA-UHFFFAOYSA-N 50415610 CHEMBL1086653 Mitogen-activated protein kinase 10 Homo sapiens 6309.57 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415610&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881329 163364634 CHEMBL1086653 ZINC49049277 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014817 COc1cc2CCN=C(c3ccc(Cl)cc3)c2cc1OC InChI=1S/C17H16ClNO2/c1-20-15-9-12-7-8-19-17(14(12)10-16(15)21-2)11-3-5-13(18)6-4-11/h3-6,9-10H,7-8H2,1-2H3 PAYKLHWMLACKAE-UHFFFAOYSA-N 50415611 CHEMBL1086784 Mitogen-activated protein kinase 10 Homo sapiens >15848.93 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415611&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2823737 163364635 CHEMBL1086784 ZINC03083156 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51014818 COc1cc2CCN=C(c3cccc(Cl)c3F)c2cc1Cl InChI=1S/C16H12Cl2FNO/c1-21-14-7-9-5-6-20-16(11(9)8-13(14)18)10-3-2-4-12(17)15(10)19/h2-4,7-8H,5-6H2,1H3 CBQQSSIKINIQJI-UHFFFAOYSA-N 50415624 CHEMBL1077129 Mitogen-activated protein kinase 10 Homo sapiens 630.96 ChEMBL 10.1016/j.bmcl.2009.02.098 10.7270/Q2Z320WR 19303774 Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50415624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50415624&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46881359 163364648 CHEMBL1077129 ZINC49048862 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059712 Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(NC4CCOCC4)n3)c2c1 InChI=1S/C26H23N5O2/c32-21-7-8-22-23(16-21)31(24-9-12-27-26(30-24)28-20-10-13-33-14-11-20)25(29-22)19-6-5-17-3-1-2-4-18(17)15-19/h1-9,12,15-16,20,32H,10-11,13-14H2,(H,27,28,30) WGEXIJRKFDQJCS-UHFFFAOYSA-N 50430434 CHEMBL2334703 Mitogen-activated protein kinase 10 Homo sapiens 6000 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430434&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584210 164159309 CHEMBL2334703 ZINC95590170 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059713 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCOCC2)n1 InChI=1S/C26H23N5O2/c32-21-7-8-23-22(16-21)29-25(19-6-5-17-3-1-2-4-18(17)15-19)31(23)24-9-12-27-26(30-24)28-20-10-13-33-14-11-20/h1-9,12,15-16,20,32H,10-11,13-14H2,(H,27,28,30) XOZSAGRTIVKDDL-UHFFFAOYSA-N 50430435 CHEMBL2334702 Mitogen-activated protein kinase 10 Homo sapiens 1660 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430435&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584209 164159310 CHEMBL2334702 ZINC95587181 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059714 Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(NC4CCCCC4)n3)c2c1 InChI=1S/C27H25N5O/c33-22-12-13-23-24(17-22)32(25-14-15-28-27(31-25)29-21-8-2-1-3-9-21)26(30-23)20-11-10-18-6-4-5-7-19(18)16-20/h4-7,10-17,21,33H,1-3,8-9H2,(H,28,29,31) NDZUGGRYLOMQOG-UHFFFAOYSA-N 50430436 CHEMBL2335070 Mitogen-activated protein kinase 10 Homo sapiens 31700 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430436&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584096 164159311 CHEMBL2335070 ZINC95589230 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059715 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCCCC2)n1 InChI=1S/C27H25N5O/c33-22-12-13-24-23(17-22)30-26(20-11-10-18-6-4-5-7-19(18)16-20)32(24)25-14-15-28-27(31-25)29-21-8-2-1-3-9-21/h4-7,10-17,21,33H,1-3,8-9H2,(H,28,29,31) QMIXCBREDNAFJZ-UHFFFAOYSA-N 50430437 CHEMBL2335069 Mitogen-activated protein kinase 10 Homo sapiens 1890 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430437&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584095 164159312 CHEMBL2335069 ZINC95591766 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059716 Clc1ccc(cc1Cl)-c1nc2ccccc2n1-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H24Cl2N6O/c27-19-10-9-17(14-20(19)28)24-31-21-5-1-2-6-22(21)34(24)23-11-12-29-26(32-23)30-18-4-3-13-33(15-18)25(35)16-7-8-16/h1-2,5-6,9-12,14,16,18H,3-4,7-8,13,15H2,(H,29,30,32)/t18-/m1/s1 HHDRDYGKYXSQBA-GOSISDBHSA-N 50430438 CHEMBL2335068 Mitogen-activated protein kinase 10 Homo sapiens 7690 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430438&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584094 164159313 CHEMBL2335068 ZINC95591290 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059717 COc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C4)C(=O)C4CC4)n3)c2c1 InChI=1S/C31H30N6O2/c1-39-25-12-13-26-27(18-25)37(29(34-26)23-11-8-20-5-2-3-6-22(20)17-23)28-14-15-32-31(35-28)33-24-7-4-16-36(19-24)30(38)21-9-10-21/h2-3,5-6,8,11-15,17-18,21,24H,4,7,9-10,16,19H2,1H3,(H,32,33,35)/t24-/m1/s1 HWLPUOSBEAGBSQ-XMMPIXPASA-N 50430439 CHEMBL2335067 Mitogen-activated protein kinase 10 Homo sapiens 1170 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430439&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584093 164159314 CHEMBL2335067 ZINC95586629 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059718 COc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C31H30N6O2/c1-39-25-12-13-27-26(18-25)34-29(23-11-8-20-5-2-3-6-22(20)17-23)37(27)28-14-15-32-31(35-28)33-24-7-4-16-36(19-24)30(38)21-9-10-21/h2-3,5-6,8,11-15,17-18,21,24H,4,7,9-10,16,19H2,1H3,(H,32,33,35)/t24-/m1/s1 LNKSHWILIURXAN-XMMPIXPASA-N 50430440 CHEMBL2335066 Mitogen-activated protein kinase 10 Homo sapiens 2910 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430440&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584092 164159315 CHEMBL2335066 ZINC95591670 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059719 O=C(C1CC1)N1CCC[C@H](C1)Nc1nccc(n1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C30H28N6O/c37-29(21-12-13-21)35-17-5-8-24(19-35)32-30-31-16-15-27(34-30)36-26-10-4-3-9-25(26)33-28(36)23-14-11-20-6-1-2-7-22(20)18-23/h1-4,6-7,9-11,14-16,18,21,24H,5,8,12-13,17,19H2,(H,31,32,34)/t24-/m1/s1 PGKIIPYIXYUNOE-XMMPIXPASA-N 50430441 CHEMBL2335065 Mitogen-activated protein kinase 10 Homo sapiens 1930 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430441&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583990 164159316 CHEMBL2335065 ZINC95589236 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059720 C1CNC[C@@H](C1)Nc1nccc(n1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C26H24N6/c1-2-7-19-16-20(12-11-18(19)6-1)25-30-22-9-3-4-10-23(22)32(25)24-13-15-28-26(31-24)29-21-8-5-14-27-17-21/h1-4,6-7,9-13,15-16,21,27H,5,8,14,17H2,(H,28,29,31)/t21-/m1/s1 QTZBCHXGQNTVCK-OAQYLSRUSA-N 50430442 CHEMBL2335064 Mitogen-activated protein kinase 10 Homo sapiens 2980 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430442&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71717015 164159317 CHEMBL2335064 ZINC95592420 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059721 Clc1ccc(cc1Cl)-c1nc2ccccc2n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C22H19Cl2N5O/c23-16-6-5-14(13-17(16)24)21-27-18-3-1-2-4-19(18)29(21)20-7-10-25-22(28-20)26-15-8-11-30-12-9-15/h1-7,10,13,15H,8-9,11-12H2,(H,25,26,28) NUBHHICZZNJVSS-UHFFFAOYSA-N 50430443 CHEMBL2334723 Mitogen-activated protein kinase 10 Homo sapiens 21800 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430443&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583989 164159318 CHEMBL2334723 ZINC95589249 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059722 COc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(NC4CCCCC4)n3)c2c1 InChI=1S/C28H27N5O/c1-34-23-13-14-24-25(18-23)33(26-15-16-29-28(32-26)30-22-9-3-2-4-10-22)27(31-24)21-12-11-19-7-5-6-8-20(19)17-21/h5-8,11-18,22H,2-4,9-10H2,1H3,(H,29,30,32) QJPWQJPSTPILRY-UHFFFAOYSA-N 50430444 CHEMBL2334722 Mitogen-activated protein kinase 10 Homo sapiens 1770 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430444&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583988 164159319 CHEMBL2334722 ZINC95586645 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059723 COc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCCCC2)n1 InChI=1S/C28H27N5O/c1-34-23-13-14-25-24(18-23)31-27(21-12-11-19-7-5-6-8-20(19)17-21)33(25)26-15-16-29-28(32-26)30-22-9-3-2-4-10-22/h5-8,11-18,22H,2-4,9-10H2,1H3,(H,29,30,32) BLYQNHCDMISTOE-UHFFFAOYSA-N 50430445 CHEMBL2334721 Mitogen-activated protein kinase 10 Homo sapiens 743 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430445&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583987 164159320 CHEMBL2334721 ZINC95586467 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059724 C1CC(CCO1)Nc1nccc(n1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C26H23N5O/c1-2-6-19-17-20(10-9-18(19)5-1)25-29-22-7-3-4-8-23(22)31(25)24-11-14-27-26(30-24)28-21-12-15-32-16-13-21/h1-11,14,17,21H,12-13,15-16H2,(H,27,28,30) PFISUKKTQWGHME-UHFFFAOYSA-N 50430446 CHEMBL2334720 Mitogen-activated protein kinase 10 Homo sapiens 2330 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430446&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583986 164159321 CHEMBL2334720 ZINC95586173 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059725 C1CCC(CC1)Nc1nccc(n1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C27H25N5/c1-2-10-22(11-3-1)29-27-28-17-16-25(31-27)32-24-13-7-6-12-23(24)30-26(32)21-15-14-19-8-4-5-9-20(19)18-21/h4-9,12-18,22H,1-3,10-11H2,(H,28,29,31) YHHANOMLSREBSQ-UHFFFAOYSA-N 50430447 CHEMBL2334719 Mitogen-activated protein kinase 10 Homo sapiens 1750 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430447&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583889 164159322 CHEMBL2334719 ZINC95586463 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059726 Oc1ccc2n(c(nc2c1)-c1ccc(Cl)c(Cl)c1)-c1ccnc(NC2CCCCC2)c1 InChI=1S/C24H22Cl2N4O/c25-19-8-6-15(12-20(19)26)24-29-21-14-18(31)7-9-22(21)30(24)17-10-11-27-23(13-17)28-16-4-2-1-3-5-16/h6-14,16,31H,1-5H2,(H,27,28) NITZJWDXCWRXAP-UHFFFAOYSA-N 50430448 CHEMBL2334718 Mitogen-activated protein kinase 10 Homo sapiens 13800 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430448&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583888 164159323 CHEMBL2334718 ZINC95589012 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059727 C[C@H](O)CNc1cc(ccn1)-n1c(nc2ccccc12)-c1cccc(O)c1 InChI=1S/C21H20N4O2/c1-14(26)13-23-20-12-16(9-10-22-20)25-19-8-3-2-7-18(19)24-21(25)15-5-4-6-17(27)11-15/h2-12,14,26-27H,13H2,1H3,(H,22,23)/t14-/m0/s1 AEVXBTIKHBFACQ-AWEZNQCLSA-N 50430449 CHEMBL2334717 Mitogen-activated protein kinase 10 Homo sapiens 19100 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430449&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583887 164159324 CHEMBL2334717 ZINC95587611 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059728 Oc1cccc(c1)-c1nc2ccccc2n1-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)c1 InChI=1S/C27H27N5O2/c33-22-7-3-5-19(15-22)26-30-23-8-1-2-9-24(23)32(26)21-12-13-28-25(16-21)29-20-6-4-14-31(17-20)27(34)18-10-11-18/h1-3,5,7-9,12-13,15-16,18,20,33H,4,6,10-11,14,17H2,(H,28,29)/t20-/m1/s1 CQERWDWSCNZVRB-HXUWFJFHSA-N 50430450 CHEMBL2334716 Mitogen-activated protein kinase 10 Homo sapiens 2640 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430450&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583886 164159325 CHEMBL2334716 ZINC95586236 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059729 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)c1 InChI=1S/C31H29N5O2/c37-26-11-12-28-27(18-26)34-30(23-10-7-20-4-1-2-5-22(20)16-23)36(28)25-13-14-32-29(17-25)33-24-6-3-15-35(19-24)31(38)21-8-9-21/h1-2,4-5,7,10-14,16-18,21,24,37H,3,6,8-9,15,19H2,(H,32,33)/t24-/m1/s1 ROGYDKSLJQXHRH-XMMPIXPASA-N 50430451 CHEMBL2334715 Mitogen-activated protein kinase 10 Homo sapiens 27700 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430451&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583885 164159326 CHEMBL2334715 ZINC95587636 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059730 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(N[C@@H]2CCCNC2)c1 InChI=1S/C27H25N5O/c33-23-9-10-25-24(16-23)31-27(20-8-7-18-4-1-2-5-19(18)14-20)32(25)22-11-13-29-26(15-22)30-21-6-3-12-28-17-21/h1-2,4-5,7-11,13-16,21,28,33H,3,6,12,17H2,(H,29,30)/t21-/m1/s1 PERLLRDOEGMSEP-OAQYLSRUSA-N 50430452 CHEMBL2334714 Mitogen-activated protein kinase 10 Homo sapiens 6050 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430452&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583884 164159327 CHEMBL2334714 ZINC95592871 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059731 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCOCC2)c1 InChI=1S/C27H24N4O2/c32-23-7-8-25-24(17-23)30-27(20-6-5-18-3-1-2-4-19(18)15-20)31(25)22-9-12-28-26(16-22)29-21-10-13-33-14-11-21/h1-9,12,15-17,21,32H,10-11,13-14H2,(H,28,29) KVGMNWJSHWIYDZ-UHFFFAOYSA-N 50430453 CHEMBL2334713 Mitogen-activated protein kinase 10 Homo sapiens 10000 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430453&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583771 164159328 CHEMBL2334713 ZINC95591552 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059732 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(NC2CCCCC2)c1 InChI=1S/C28H26N4O/c33-24-12-13-26-25(18-24)31-28(21-11-10-19-6-4-5-7-20(19)16-21)32(26)23-14-15-29-27(17-23)30-22-8-2-1-3-9-22/h4-7,10-18,22,33H,1-3,8-9H2,(H,29,30) HSZNPLMQJHQVIP-UHFFFAOYSA-N 50430454 CHEMBL2334712 Mitogen-activated protein kinase 10 Homo sapiens 24500 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430454&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583770 164159329 CHEMBL2334712 ZINC95587691 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059733 O=C(C1CC1)N1CCC[C@H](C1)Nc1cc(ccn1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C31H29N5O/c37-31(22-12-13-22)35-17-5-8-25(20-35)33-29-19-26(15-16-32-29)36-28-10-4-3-9-27(28)34-30(36)24-14-11-21-6-1-2-7-23(21)18-24/h1-4,6-7,9-11,14-16,18-19,22,25H,5,8,12-13,17,20H2,(H,32,33)/t25-/m1/s1 RTDQAEAZHTXYSM-RUZDIDTESA-N 50430455 CHEMBL2334711 Mitogen-activated protein kinase 10 Homo sapiens 10700 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430455&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583769 164159330 CHEMBL2334711 ZINC95588909 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059734 COc1ccc2n(c(nc2c1)-c1ccc(C)c(Cl)c1)-c1ccnc(NC2CCCCC2)c1 InChI=1S/C26H27ClN4O/c1-17-8-9-18(14-22(17)27)26-30-23-16-21(32-2)10-11-24(23)31(26)20-12-13-28-25(15-20)29-19-6-4-3-5-7-19/h8-16,19H,3-7H2,1-2H3,(H,28,29) QZKPHMPRUAZGCF-UHFFFAOYSA-N 50432395 CHEMBL2348778 Mitogen-activated protein kinase 10 Homo sapiens 18100 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432395&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71717144 164161270 CHEMBL2348778 ZINC95602277 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059735 C[C@H](O)CNc1cc(ccn1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C25H22N4O/c1-17(30)16-27-24-15-21(12-13-26-24)29-23-9-5-4-8-22(23)28-25(29)20-11-10-18-6-2-3-7-19(18)14-20/h2-15,17,30H,16H2,1H3,(H,26,27)/t17-/m0/s1 VLBRXKUTMFGCOE-KRWDZBQOSA-N 50430458 CHEMBL2334708 Mitogen-activated protein kinase 10 Homo sapiens 12700 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430458&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583767 164159333 CHEMBL2334708 ZINC95592497 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059736 C1CC(CCO1)Nc1cc(ccn1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C27H24N4O/c1-2-6-20-17-21(10-9-19(20)5-1)27-30-24-7-3-4-8-25(24)31(27)23-11-14-28-26(18-23)29-22-12-15-32-16-13-22/h1-11,14,17-18,22H,12-13,15-16H2,(H,28,29) JZQQOKUENCAWLR-UHFFFAOYSA-N 50430459 CHEMBL2334707 Mitogen-activated protein kinase 10 Homo sapiens 4650 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430459&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583766 164159334 CHEMBL2334707 ZINC95587918 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059737 C1CCC(CC1)Nc1cc(ccn1)-n1c(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C28H26N4/c1-2-10-23(11-3-1)30-27-19-24(16-17-29-27)32-26-13-7-6-12-25(26)31-28(32)22-15-14-20-8-4-5-9-21(20)18-22/h4-9,12-19,23H,1-3,10-11H2,(H,29,30) IGWWQFBSMMAYKV-UHFFFAOYSA-N 50430460 CHEMBL2334706 Mitogen-activated protein kinase 10 Homo sapiens 5260 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430460&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71583660 164159335 CHEMBL2334706 ZINC95586682 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059738 Oc1cccc(c1)-c1nc2ccccc2n1-c1ccnc(N[C@@H]2CCCNC2)c1 InChI=1S/C23H23N5O/c29-19-7-3-5-16(13-19)23-27-20-8-1-2-9-21(20)28(23)18-10-12-25-22(14-18)26-17-6-4-11-24-15-17/h1-3,5,7-10,12-14,17,24,29H,4,6,11,15H2,(H,25,26)/t17-/m1/s1 GFSMRUUAQITBGI-QGZVFWFLSA-N 50432394 CHEMBL2348581 Mitogen-activated protein kinase 10 Homo sapiens 1860 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50432394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50432394&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71720177 164161269 CHEMBL2348581 ZINC95605591 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059739 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 10000 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059740 Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C4)C(=O)C4CC4)n3)c2c1 InChI=1S/C30H28N6O2/c37-24-11-12-25-26(17-24)36(28(33-25)22-10-7-19-4-1-2-5-21(19)16-22)27-13-14-31-30(34-27)32-23-6-3-15-35(18-23)29(38)20-8-9-20/h1-2,4-5,7,10-14,16-17,20,23,37H,3,6,8-9,15,18H2,(H,31,32,34)/t23-/m1/s1 GQWKCVUFYCHSLR-HSZRJFAPSA-N 50430432 CHEMBL2334705 Mitogen-activated protein kinase 10 Homo sapiens 1090 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430432&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1RQ 4KKH 71584212 164159307 CHEMBL2334705 ZINC95587066 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059741 Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@@H]4CCCN(C4)C(=O)C4CC4)n3)c2c1 InChI=1S/C30H28N6O2/c37-24-11-12-25-26(17-24)36(28(33-25)22-10-7-19-4-1-2-5-21(19)16-22)27-13-14-31-30(34-27)32-23-6-3-15-35(18-23)29(38)20-8-9-20/h1-2,4-5,7,10-14,16-17,20,23,37H,3,6,8-9,15,18H2,(H,31,32,34)/t23-/m1/s1 GQWKCVUFYCHSLR-HSZRJFAPSA-N 50430432 CHEMBL2334705 Mitogen-activated protein kinase 10 Homo sapiens 46 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430432&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1RQ 4KKH 71584212 164159307 CHEMBL2334705 ZINC95587066 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51059742 Oc1ccc2n(c(nc2c1)-c1ccc2ccccc2c1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C30H28N6O2/c37-24-11-12-26-25(17-24)33-28(22-10-7-19-4-1-2-5-21(19)16-22)36(26)27-13-14-31-30(34-27)32-23-6-3-15-35(18-23)29(38)20-8-9-20/h1-2,4-5,7,10-14,16-17,20,23,37H,3,6,8-9,15,18H2,(H,31,32,34)/t23-/m1/s1 NONWPZRMZADEMH-HSZRJFAPSA-N 50430433 CHEMBL2334704 Mitogen-activated protein kinase 10 Homo sapiens 2650 ChEMBL 10.1016/j.bmc.2013.02.021 10.7270/Q29W0GVC 23498914 Kim, MH; Lee, J; Jung, K; Kim, M; Park, YJ; Ahn, H; Kwon, YH; Hah, JM Hanyang University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50430433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50430433&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71584211 164159308 CHEMBL2334704 ZINC95591267 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715705 CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4ccc(NC(=O)C=C)cc4)cc3)c2)n1C)-c1ccc(F)cc1 InChI=1S/C32H27FN6O2S/c1-4-28(40)36-25-11-7-21(8-12-25)31(41)37-26-15-13-24(14-16-26)35-27-19-22(17-18-34-27)30-29(38-32(42-3)39(30)2)20-5-9-23(33)10-6-20/h4-19H,1H2,2-3H3,(H,34,35)(H,36,40)(H,37,41) FGUMAGUMQGZTJF-UHFFFAOYSA-N 50234877 CHEMBL4101953 Mitogen-activated protein kinase 10 Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234877&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137661932 384584929 CHEMBL4101953 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715706 CCC(=O)Nc1cccc(c1)C(=O)Nc1cccc(Nc2cc(ccn2)-c2c(nc(SC)n2C)-c2ccc(F)cc2)c1 InChI=1S/C32H29FN6O2S/c1-4-28(40)36-24-8-5-7-22(17-24)31(41)37-26-10-6-9-25(19-26)35-27-18-21(15-16-34-27)30-29(38-32(42-3)39(30)2)20-11-13-23(33)14-12-20/h5-19H,4H2,1-3H3,(H,34,35)(H,36,40)(H,37,41) WOWCIXUPGGJLRY-UHFFFAOYSA-N 50234878 CHEMBL4077684 Mitogen-activated protein kinase 10 Homo sapiens 175 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234878&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137649558 384584930 CHEMBL4077684 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715707 CSc1nc(c(-c2ccnc(Nc3cccc(NC(=O)c4cccc(NC(=O)C=C)c4)c3)c2)n1C)-c1ccc(F)cc1 InChI=1S/C32H27FN6O2S/c1-4-28(40)36-24-8-5-7-22(17-24)31(41)37-26-10-6-9-25(19-26)35-27-18-21(15-16-34-27)30-29(38-32(42-3)39(30)2)20-11-13-23(33)14-12-20/h4-19H,1H2,2-3H3,(H,34,35)(H,36,40)(H,37,41) CHWHUQGYVMHMGN-UHFFFAOYSA-N 50234879 CHEMBL4094220 Mitogen-activated protein kinase 10 Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234879&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137654276 384584931 CHEMBL4094220 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50715708 CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(NC(=O)C=C)c4C)cc3)c2)n1C)-c1ccc(F)cc1 InChI=1S/C33H29FN6O2S/c1-5-29(41)38-27-8-6-7-26(20(27)2)32(42)37-25-15-13-24(14-16-25)36-28-19-22(17-18-35-28)31-30(39-33(43-4)40(31)3)21-9-11-23(34)12-10-21/h5-19H,1H2,2-4H3,(H,35,36)(H,37,42)(H,38,41) WOTWLRUBONIHLC-UHFFFAOYSA-N 50234880 CHEMBL4086457 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234880&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137643579 384584932 CHEMBL4086457 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716005 CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(N)c4)cc3)c2)n1C)-c1ccc(F)cc1 InChI=1S/C29H25FN6OS/c1-36-27(26(35-29(36)38-2)18-6-8-21(30)9-7-18)19-14-15-32-25(17-19)33-23-10-12-24(13-11-23)34-28(37)20-4-3-5-22(31)16-20/h3-17H,31H2,1-2H3,(H,32,33)(H,34,37) MJUMMJXVFYUVJS-UHFFFAOYSA-N 50234881 CHEMBL4104351 Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234881&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137657498 384584933 CHEMBL4104351 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716007 CCC(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2cc(ccn2)-c2c(nc(SC)n2C)-c2ccc(F)cc2)cc1 InChI=1S/C32H29FN6O2S/c1-4-28(40)36-26-7-5-6-22(18-26)31(41)37-25-14-12-24(13-15-25)35-27-19-21(16-17-34-27)30-29(38-32(42-3)39(30)2)20-8-10-23(33)11-9-20/h5-19H,4H2,1-3H3,(H,34,35)(H,36,40)(H,37,41) UKLFJWKRYNOIGW-UHFFFAOYSA-N 50234882 CHEMBL4092482 Mitogen-activated protein kinase 10 Homo sapiens 23 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234882&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 0G3 7ORF 137652755 384584934 CHEMBL4092482 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716026 CCC(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2cc(ccn2)-c2[nH]c(SC)nc2-c2ccc(F)cc2)cc1 InChI=1S/C31H27FN6O2S/c1-3-27(39)35-25-6-4-5-21(17-25)30(40)36-24-13-11-23(12-14-24)34-26-18-20(15-16-33-26)29-28(37-31(38-29)41-2)19-7-9-22(32)10-8-19/h4-18H,3H2,1-2H3,(H,33,34)(H,35,39)(H,36,40)(H,37,38) ZBXKCENUEFHXCB-UHFFFAOYSA-N 50234883 CHEMBL4069805 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234883&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137639840 384584935 CHEMBL4069805 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716029 CSc1nc(c([nH]1)-c1ccnc(Nc2ccc(NC(=O)c3ccc(NC(=O)C=C)cc3)cc2)c1)-c1ccc(F)cc1 InChI=1S/C31H25FN6O2S/c1-3-27(39)35-24-10-6-20(7-11-24)30(40)36-25-14-12-23(13-15-25)34-26-18-21(16-17-33-26)29-28(37-31(38-29)41-2)19-4-8-22(32)9-5-19/h3-18H,1H2,2H3,(H,33,34)(H,35,39)(H,36,40)(H,37,38) NIQVLUYKQSAUSE-UHFFFAOYSA-N 50234884 CHEMBL4082212 Mitogen-activated protein kinase 10 Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234884&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137646697 384584936 CHEMBL4082212 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716049 CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(NC(=O)C=C)c4)cc3C)c2)n1C)-c1ccc(F)cc1 InChI=1S/C33H29FN6O2S/c1-5-29(41)36-25-8-6-7-23(18-25)32(42)37-26-13-14-27(20(2)17-26)38-28-19-22(15-16-35-28)31-30(39-33(43-4)40(31)3)21-9-11-24(34)12-10-21/h5-19H,1H2,2-4H3,(H,35,38)(H,36,41)(H,37,42) JSOCRZCXAZAHPO-UHFFFAOYSA-N 50234885 CHEMBL4092555 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234885&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137655822 384584937 CHEMBL4092555 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716051 CSc1nc(C)c([nH]1)-c1ccnc(Nc2ccc(NC(=O)c3cccc(NC(=O)C=C)c3)cc2)c1 InChI=1S/C26H24N6O2S/c1-4-23(33)30-21-7-5-6-18(14-21)25(34)31-20-10-8-19(9-11-20)29-22-15-17(12-13-27-22)24-16(2)28-26(32-24)35-3/h4-15H,1H2,2-3H3,(H,27,29)(H,28,32)(H,30,33)(H,31,34) BKUSJXDWGAHZNA-UHFFFAOYSA-N 50234886 CHEMBL4082278 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234886&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137646016 384584938 CHEMBL4082278 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716071 CSc1nc(C)c([nH]1)-c1ccnc(Nc2ccc(NC(=O)c3ccc(NC(=O)C=C)cc3)cc2)c1 InChI=1S/C26H24N6O2S/c1-4-23(33)30-20-7-5-17(6-8-20)25(34)31-21-11-9-19(10-12-21)29-22-15-18(13-14-27-22)24-16(2)28-26(32-24)35-3/h4-15H,1H2,2-3H3,(H,27,29)(H,28,32)(H,30,33)(H,31,34) UGWXDOXBYBQDPY-UHFFFAOYSA-N 50234887 CHEMBL4100292 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234887&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137660956 384584939 CHEMBL4100292 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716073 CSc1nc(c([nH]1)-c1ccnc(Nc2ccc(N)cc2)c1)-c1ccc(F)cc1 InChI=1S/C21H18FN5S/c1-28-21-26-19(13-2-4-15(22)5-3-13)20(27-21)14-10-11-24-18(12-14)25-17-8-6-16(23)7-9-17/h2-12H,23H2,1H3,(H,24,25)(H,26,27) ZTEDFSIIEDNHLZ-UHFFFAOYSA-N 50234888 CHEMBL4074524 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234888&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137641182 384584940 CHEMBL4074524 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716625 CSc1nc(c(-c2ccnc(Nc3cccc(NC(=O)c4cccc(NC(=O)C=C)c4C)c3)c2)n1C)-c1ccc(F)cc1 InChI=1S/C33H29FN6O2S/c1-5-29(41)38-27-11-7-10-26(20(27)2)32(42)37-25-9-6-8-24(19-25)36-28-18-22(16-17-35-28)31-30(39-33(43-4)40(31)3)21-12-14-23(34)15-13-21/h5-19H,1H2,2-4H3,(H,35,36)(H,37,42)(H,38,41) JXIRXFNFPFUNQQ-UHFFFAOYSA-N 50234895 CHEMBL4071770 Mitogen-activated protein kinase 10 Homo sapiens 3.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234895&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137638967 384584947 CHEMBL4071770 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716626 CCC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Nc2cc(ccn2)-c2c(nc(SC)n2C)-c2ccc(F)cc2)c(C)c1 InChI=1S/C33H31FN6O2S/c1-5-29(41)36-25-12-8-22(9-13-25)32(42)37-26-14-15-27(20(2)18-26)38-28-19-23(16-17-35-28)31-30(39-33(43-4)40(31)3)21-6-10-24(34)11-7-21/h6-19H,5H2,1-4H3,(H,35,38)(H,36,41)(H,37,42) UYSFVRNMYWGKIE-UHFFFAOYSA-N 50234897 CHEMBL4093282 Mitogen-activated protein kinase 10 Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234897&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137656311 384584949 CHEMBL4093282 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716627 CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4ccc(NC(=O)C=C)cc4)cc3C)c2)n1C)-c1ccc(F)cc1 InChI=1S/C33H29FN6O2S/c1-5-29(41)36-25-12-8-22(9-13-25)32(42)37-26-14-15-27(20(2)18-26)38-28-19-23(16-17-35-28)31-30(39-33(43-4)40(31)3)21-6-10-24(34)11-7-21/h5-19H,1H2,2-4H3,(H,35,38)(H,36,41)(H,37,42) PUTQVTISQZRODW-UHFFFAOYSA-N 50234893 CHEMBL4063964 Mitogen-activated protein kinase 10 Homo sapiens 8.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234893&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137636264 384584945 CHEMBL4063964 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716628 CCC(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Nc2cc(ccn2)-c2c(nc(SC)n2C)-c2ccc(F)cc2)cc1 InChI=1S/C32H29FN6O2S/c1-4-28(40)36-25-11-7-21(8-12-25)31(41)37-26-15-13-24(14-16-26)35-27-19-22(17-18-34-27)30-29(38-32(42-3)39(30)2)20-5-9-23(33)10-6-20/h5-19H,4H2,1-3H3,(H,34,35)(H,36,40)(H,37,41) OIENACMNANMKKJ-UHFFFAOYSA-N 50234892 CHEMBL4085536 Mitogen-activated protein kinase 10 Homo sapiens 27 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234892&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137645681 384584944 CHEMBL4085536 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716629 CSc1nc(c(-c2ccnc(Nc3cccc(NC(=O)c4ccc(NC(=O)C=C)cc4)c3)c2)n1C)-c1ccc(F)cc1 InChI=1S/C32H27FN6O2S/c1-4-28(40)36-24-14-10-21(11-15-24)31(41)37-26-7-5-6-25(19-26)35-27-18-22(16-17-34-27)30-29(38-32(42-3)39(30)2)20-8-12-23(33)13-9-20/h4-19H,1H2,2-3H3,(H,34,35)(H,36,40)(H,37,41) SMBXDJJTCBKNRG-UHFFFAOYSA-N 50234894 CHEMBL4072555 Mitogen-activated protein kinase 10 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234894&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137639936 384584946 CHEMBL4072555 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716635 CCC(=O)Nc1cccc(C(=O)Nc2ccc(Nc3cc(ccn3)-c3c(nc(SC)n3C)-c3ccc(F)cc3)cc2)c1C InChI=1S/C33H31FN6O2S/c1-5-29(41)38-27-8-6-7-26(20(27)2)32(42)37-25-15-13-24(14-16-25)36-28-19-22(17-18-35-28)31-30(39-33(43-4)40(31)3)21-9-11-23(34)12-10-21/h6-19H,5H2,1-4H3,(H,35,36)(H,37,42)(H,38,41) QLEWHSZIKRAOAP-UHFFFAOYSA-N 50234891 CHEMBL4066691 Mitogen-activated protein kinase 10 Homo sapiens 17 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234891&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137631713 384584943 CHEMBL4066691 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716636 CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(NC(=O)C=C)c4)cc3)c2)n1C)-c1ccc(F)cc1 InChI=1S/C32H27FN6O2S/c1-4-28(40)36-26-7-5-6-22(18-26)31(41)37-25-14-12-24(13-15-25)35-27-19-21(16-17-34-27)30-29(38-32(42-3)39(30)2)20-8-10-23(33)11-9-20/h4-19H,1H2,2-3H3,(H,34,35)(H,36,40)(H,37,41) SHSDJTLZMWMUMU-UHFFFAOYSA-N 50234890 CHEMBL4077018 Mitogen-activated protein kinase 10 Homo sapiens 0.300000 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234890&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137650943 384584942 CHEMBL4077018 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716637 CSc1nc(c([nH]1)-c1ccnc(Nc2ccc(NC(=O)c3cccc(NC(=O)C=C)c3)cc2)c1)-c1ccc(F)cc1 InChI=1S/C31H25FN6O2S/c1-3-27(39)35-25-6-4-5-21(17-25)30(40)36-24-13-11-23(12-14-24)34-26-18-20(15-16-33-26)29-28(37-31(38-29)41-2)19-7-9-22(32)10-8-19/h3-18H,1H2,2H3,(H,33,34)(H,35,39)(H,36,40)(H,37,38) FDNUPMASTHASFG-UHFFFAOYSA-N 50234889 CHEMBL4062023 Mitogen-activated protein kinase 10 Homo sapiens 0.600000 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234889&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137637551 384584941 CHEMBL4062023 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50716638 CCC(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2cc(ccn2)-c2[nH]c(SC)nc2C)cc1 InChI=1S/C26H26N6O2S/c1-4-23(33)30-21-7-5-6-18(14-21)25(34)31-20-10-8-19(9-11-20)29-22-15-17(12-13-27-22)24-16(2)28-26(32-24)35-3/h5-15H,4H2,1-3H3,(H,27,29)(H,28,32)(H,30,33)(H,31,34) PODJOAYTRKCFAG-UHFFFAOYSA-N 50234896 CHEMBL4101252 Mitogen-activated protein kinase 10 Homo sapiens 253 ChEMBL 10.1021/acs.jmedchem.6b01180 10.7270/Q2891854 27977190 Muth, F; El-Gokha, A; Ansideri, F; Eitel, M; Döring, E; Sievers-Engler, A; Lange, A; Boeckler, FM; Lämmerhofer, M; Koch, P; Laufer, SA Eberhard Karls Universit£t T£bingen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234896&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137660093 384584948 CHEMBL4101252 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695801 O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1cc[nH]n1 InChI=1S/C19H15N3OS/c23-18(12-14-6-3-5-13-4-1-2-7-15(13)14)21-16-9-11-24-19(16)17-8-10-20-22-17/h1-11H,12H2,(H,20,22)(H,21,23) RAIUWRMGPSZDJL-UHFFFAOYSA-N 50332069 CHEMBL1287915::N-(2-(1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 72 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332069&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869075 123111184 CHEMBL1287915 ZINC64559414 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695803 Cn1ccc(n1)-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C20H17N3OS/c1-23-11-9-18(22-23)20-17(10-12-25-20)21-19(24)13-15-7-4-6-14-5-2-3-8-16(14)15/h2-12H,13H2,1H3,(H,21,24) UNKZYKXHTPRCOC-UHFFFAOYSA-N 50332072 CHEMBL1287945::N-(2-(1-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 73 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332072&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869147 123111187 CHEMBL1287945 ZINC64549835 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695805 Cc1cc(n[nH]1)-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C20H17N3OS/c1-13-11-18(23-22-13)20-17(9-10-25-20)21-19(24)12-15-7-4-6-14-5-2-3-8-16(14)15/h2-11H,12H2,1H3,(H,21,24)(H,22,23) WECVVDLKMBWACI-UHFFFAOYSA-N 50332075 CHEMBL1288004::N-(2-(5-methyl-1H-pyrazol-3-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 74 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332075&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869223 123111190 CHEMBL1288004 ZINC64559152 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695807 COc1ccc(CC(=O)Nc2sccc2-c2nn[nH]n2)cc1 InChI=1S/C14H13N5O2S/c1-21-10-4-2-9(3-5-10)8-12(20)15-14-11(6-7-22-14)13-16-18-19-17-13/h2-7H,8H2,1H3,(H,15,20)(H,16,17,18,19) MTAABTKZYUWXQA-UHFFFAOYSA-N 351631 N-(3-(2H-tetrazol-5-yl)thiophen-2-yl)-2-(4-methoxyphenyl)-acetamide::US9796706, Compound 75 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351631&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 139208019 386046047 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695809 COc1ccc(CC(=O)Nc2sccc2-c2nnn(C)n2)cc1 InChI=1S/C15H15N5O2S/c1-20-18-14(17-19-20)12-7-8-23-15(12)16-13(21)9-10-3-5-11(22-2)6-4-10/h3-8H,9H2,1-2H3,(H,16,21) CYZHBOBJYJSPNB-UHFFFAOYSA-N 351632 2-(4-methoxyphenyl)-N-(3-(2-methyl-2H-tetrazol-5-yl)thiophen-2-yl)acetamide::US9796706, Compound 76 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869225 386046048 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695812 COCn1nnnc1-c1ccsc1NC(=O)Cc1ccc(OC)cc1 InChI=1S/C16H17N5O3S/c1-23-10-21-15(18-19-20-21)13-7-8-25-16(13)17-14(22)9-11-3-5-12(24-2)6-4-11/h3-8H,9-10H2,1-2H3,(H,17,22) RMCRSAOJEGBRHB-UHFFFAOYSA-N 351633 N-(3-(1-(methoxymethyl)-1H-tetrazol-5-yl)thiophen-2-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 77 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869152 386046049 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695814 Cn1ccnc1-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C20H17N3OS/c1-23-11-10-21-20(23)19-17(9-12-25-19)22-18(24)13-15-7-4-6-14-5-2-3-8-16(14)15/h2-12H,13H2,1H3,(H,22,24) HNCDWUWAHZKKTE-UHFFFAOYSA-N 351634 N-(2-(1-methyl-1H-imidazol-2-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 78 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351634&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636663 386046050 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695816 COc1ccc(CC(=O)Nc2ccsc2-c2cn(C)cn2)cc1 InChI=1S/C17H17N3O2S/c1-20-10-15(18-11-20)17-14(7-8-23-17)19-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10-11H,9H2,1-2H3,(H,19,21) RYGONSQYUUISGP-UHFFFAOYSA-N 50332081 2-(4-methoxyphenyl)-N-(2-(1-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide::CHEMBL1288067::US9796706, Compound 79 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332081&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52948565 123111196 CHEMBL1288067 ZINC64559317 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695818 COc1ccc(CC(=O)Nc2ccsc2-c2c[nH]cn2)cc1 InChI=1S/C16H15N3O2S/c1-21-12-4-2-11(3-5-12)8-15(20)19-13-6-7-22-16(13)14-9-17-10-18-14/h2-7,9-10H,8H2,1H3,(H,17,18)(H,19,20) GMLSSJCTQVNALC-UHFFFAOYSA-N 351636 N-(2-(1H-imidazol-4-yl)thiophen-3-yl)-2-(4-methoxyphenyl)-acetamide::US9796706, Compound 80 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636643 386046052 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695820 O=C(CN1C(=O)CCc2ccccc12)Nc1ccsc1-c1c[nH]cn1 InChI=1S/C18H16N4O2S/c23-16(21-13-7-8-25-18(13)14-9-19-11-20-14)10-22-15-4-2-1-3-12(15)5-6-17(22)24/h1-4,7-9,11H,5-6,10H2,(H,19,20)(H,21,23) GFWLYZCXFSXTMS-UHFFFAOYSA-N 351637 N-(2-(1H-imidazol-4-yl)thiophen-3-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 81 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351637&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636667 386046053 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695823 COc1ccc(CC(=O)Nc2ccsc2-c2c[nH]c(C)n2)cc1 InChI=1S/C17H17N3O2S/c1-11-18-10-15(19-11)17-14(7-8-23-17)20-16(21)9-12-3-5-13(22-2)6-4-12/h3-8,10H,9H2,1-2H3,(H,18,19)(H,20,21) LFLTYJDEZSLZGL-UHFFFAOYSA-N 50332083 2-(4-methoxyphenyl)-N-(2-(2-methyl-1H-imidazol-4-yl)thiophen-3-yl)acetamide::CHEMBL1288069::US9796706, Compound 82 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332083&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52946092 123111198 CHEMBL1288069 ZINC64573429 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695825 Cc1nc(c[nH]1)-c1sccc1NC(=O)CN1C(=O)CCc2ccccc12 InChI=1S/C19H18N4O2S/c1-12-20-10-15(21-12)19-14(8-9-26-19)22-17(24)11-23-16-5-3-2-4-13(16)6-7-18(23)25/h2-5,8-10H,6-7,11H2,1H3,(H,20,21)(H,22,24) KDWLOOXBRPLACZ-UHFFFAOYSA-N 351639 N-(2-(2-methyl-1H-imidazol-4-yl)thiophen-3-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 83 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351639&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636655 386046055 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695827 O=C(Cc1cccc2ccccc12)Nc1ccsc1-n1ccnc1 InChI=1S/C19H15N3OS/c23-18(12-15-6-3-5-14-4-1-2-7-16(14)15)21-17-8-11-24-19(17)22-10-9-20-13-22/h1-11,13H,12H2,(H,21,23) YAMORCRLQFAZCJ-UHFFFAOYSA-N 50332068 CHEMBL1287914::N-(2-(1H-imidazol-1-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 84 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332068&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52946059 123111183 CHEMBL1287914 ZINC64559565 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695829 COc1ccc(CC(=O)Nc2ccsc2-c2cnccn2)cc1 InChI=1S/C17H15N3O2S/c1-22-13-4-2-12(3-5-13)10-16(21)20-14-6-9-23-17(14)15-11-18-7-8-19-15/h2-9,11H,10H2,1H3,(H,20,21) RVEHZFOKUTZKBA-UHFFFAOYSA-N 50332084 2-(4-methoxyphenyl)-N-(2-(pyrazin-2-yl)thiophen-3-yl)acetamide::CHEMBL1288098::US9796706, Compound 85 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332084&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52941286 123111199 CHEMBL1288098 ZINC64560182 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695832 O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cnccn1 InChI=1S/C18H13N5OS/c24-16(8-12-2-1-3-13-9-19-5-4-14(12)13)23-18-17(22-11-25-18)15-10-20-6-7-21-15/h1-7,9-11H,8H2,(H,23,24) ALHGQWSWTWVNNB-UHFFFAOYSA-N 50332090 2-(isoquinolin-5-yl)-N-(4-(pyrazin-2-yl)thiazol-5-yl)acetamide::CHEMBL1288159::US9796706, Compound 86 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332090&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52948593 123111205 CHEMBL1288159 ZINC64560844 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695835 O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1 InChI=1S/C17H12N4OS2/c22-15(6-11-2-1-3-12-7-18-5-4-13(11)12)21-17-16(20-10-24-17)14-8-23-9-19-14/h1-5,7-10H,6H2,(H,21,22) BGGSTZPBQKGLOJ-UHFFFAOYSA-N 50332091 CHEMBL1288160::N-(4,4'-bithiazol-5-yl)-2-(isoquinolin-5-yl)acetamide::US9796706, Compound 87 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332091&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 49839481 123111206 CHEMBL1288160 ZINC64573024 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695838 COc1ccc(CC(=O)Nc2ccsc2N2CCOC2=O)cc1 InChI=1S/C16H16N2O4S/c1-21-12-4-2-11(3-5-12)10-14(19)17-13-6-9-23-15(13)18-7-8-22-16(18)20/h2-6,9H,7-8,10H2,1H3,(H,17,19) JXSJAJUZRYNVGF-UHFFFAOYSA-N 50332078 2-(4-methoxyphenyl)-N-(2-(2-oxooxazolidin-3-yl)thiophen-3-yl)acetamide::CHEMBL1288037::US9796706, Compound 88 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332078&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52942482 123111193 CHEMBL1288037 ZINC64559381 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695839 Brc1csc(NC(=O)CN2C(=O)CCc3ccc(Br)cc23)c1-c1ncn[nH]1 InChI=1S/C17H13Br2N5O2S/c18-10-3-1-9-2-4-14(26)24(12(9)5-10)6-13(25)22-17-15(11(19)7-27-17)16-20-8-21-23-16/h1,3,5,7-8H,2,4,6H2,(H,22,25)(H,20,21,23) XUXMPDLBZNJZJY-UHFFFAOYSA-N 351645 2-(7-bromo-2-oxo-3,4-dihydroquinolin-1(2H)-yl)-N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)acetamide::US9796706, Compound 89 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351645&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68785163 386046061 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695842 Brc1csc(NC(=O)Cc2ccnc3ccccc23)c1-c1nnc[nH]1 InChI=1S/C17H12BrN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-5-6-19-13-4-2-1-3-11(10)13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23) JQMUEDZLTPGRSN-UHFFFAOYSA-N 351646 N-(4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(quinolin-4-yl)acetamide::US9796706, Compound 90 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351646&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68787218 386046062 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695845 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2c1 InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-2-10(18(20,21)22)5-9(12)1-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) CRWXJGJNJZPMRW-UHFFFAOYSA-N 351601 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 45::US9796706, Compound 91 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351601&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868926 386046017 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695848 Fc1ccc(CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c2ccncc12 InChI=1S/C17H11BrFN5OS/c18-12-7-26-17(15(12)16-21-8-22-24-16)23-14(25)5-9-1-2-13(19)11-6-20-4-3-10(9)11/h1-4,6-8H,5H2,(H,23,25)(H,21,22,24) OOXCRLOLUWLQCN-UHFFFAOYSA-N 351648 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(8-fluoroisoquinolin-5-yl)acetamide::US9796706, Compound 92 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351648&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56682209 386046063 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695851 Brc1csc(NC(=O)Cn2c3ccncc3ccc2=O)c1-c1ncn[nH]1 InChI=1S/C16H11BrN6O2S/c17-10-7-26-16(14(10)15-19-8-20-22-15)21-12(24)6-23-11-3-4-18-5-9(11)1-2-13(23)25/h1-5,7-8H,6H2,(H,21,24)(H,19,20,22) UJLHONOXXNLUDV-UHFFFAOYSA-N 351649 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-1,6-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 93 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351649&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56668696 386046064 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695854 Fc1ccc(CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c2cccnc12 InChI=1S/C17H11BrFN5OS/c18-11-7-26-17(14(11)16-21-8-22-24-16)23-13(25)6-9-3-4-12(19)15-10(9)2-1-5-20-15/h1-5,7-8H,6H2,(H,23,25)(H,21,22,24) KWGVWYUDDSKBHV-UHFFFAOYSA-N 351650 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(8-fluoroquinolin-5-yl)acetamide::US9796706, Compound 94 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351650&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68787234 386046065 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695857 FC(F)(F)c1cc(CC(=O)Nc2scc(Br)c2-c2nnc[nH]2)c2cccnc2c1 InChI=1S/C18H11BrF3N5OS/c19-12-7-29-17(15(12)16-24-8-25-27-16)26-14(28)5-9-4-10(18(20,21)22)6-13-11(9)2-1-3-23-13/h1-4,6-8H,5H2,(H,26,28)(H,24,25,27) ZYPRSWQPKLBUQM-UHFFFAOYSA-N 50352605 CHEMBL1822136::US9796706, Compound 95 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352605&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56658303 136359291 CHEMBL1822136 ZINC72142847 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695860 FC(F)(F)c1cc(CC(=O)Nc2scc(Br)c2-c2nnc[nH]2)cc2ncccc12 InChI=1S/C18H11BrF3N5OS/c19-12-7-29-17(15(12)16-24-8-25-27-16)26-14(28)6-9-4-11(18(20,21)22)10-2-1-3-23-13(10)5-9/h1-5,7-8H,6H2,(H,26,28)(H,24,25,27) XQRZYWOHUXJXMF-UHFFFAOYSA-N 351652 N-(4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(5-(trifluoromethyl)quinolin-7-yl)acetamide::US9796706, Compound 96 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351652&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68785093 386046067 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695863 Brc1csc(NC(=O)Cn2c3cccnc3ccc2=O)c1-c1ncn[nH]1 InChI=1S/C16H11BrN6O2S/c17-9-7-26-16(14(9)15-19-8-20-22-15)21-12(24)6-23-11-2-1-5-18-10(11)3-4-13(23)25/h1-5,7-8H,6H2,(H,21,24)(H,19,20,22) MVTVJCLMGSSGAD-UHFFFAOYSA-N 351653 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 97 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351653&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636685 386046068 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695866 Brc1csc(NC(=O)CN2C(=O)CCc3cnccc23)c1-c1ncn[nH]1 InChI=1S/C16H13BrN6O2S/c17-10-7-26-16(14(10)15-19-8-20-22-15)21-12(24)6-23-11-3-4-18-5-9(11)1-2-13(23)25/h3-5,7-8H,1-2,6H2,(H,21,24)(H,19,20,22) FPDZAKLFVYZFFE-UHFFFAOYSA-N 351654 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 98 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351654&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636644 386046069 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695869 Brc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1ncn[nH]1 InChI=1S/C16H13BrN6O2S/c17-9-7-26-16(14(9)15-19-8-20-22-15)21-12(24)6-23-11-2-1-5-18-10(11)3-4-13(23)25/h1-2,5,7-8H,3-4,6H2,(H,21,24)(H,19,20,22) JIQMILPCZGXYEY-UHFFFAOYSA-N 351655 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 99 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351655&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56661803 386046070 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695872 Clc1ccc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2c1 InChI=1S/C17H11BrClN5O2S/c18-11-7-27-17(15(11)16-20-8-21-23-16)22-13(25)6-24-12-3-2-10(19)5-9(12)1-4-14(24)26/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23) VWCSGCBTYJASKT-UHFFFAOYSA-N 351656 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-chloro-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 100 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351656&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68787233 386046071 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695875 Fc1cccc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc12 InChI=1S/C17H11BrFN5O2S/c18-10-7-27-17(15(10)16-20-8-21-23-16)22-13(25)6-24-12-3-1-2-11(19)9(12)4-5-14(24)26/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23) OSLCWXMDJMWZGK-UHFFFAOYSA-N 351657 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(5-fluoro-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 101 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351657&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68784785 386046072 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695878 Fc1cnc2c(CC(=O)Nc3scc(Br)c3-c3nc[nH]n3)cccc2c1 InChI=1S/C17H11BrFN5OS/c18-12-7-26-17(14(12)16-21-8-22-24-16)23-13(25)5-10-3-1-2-9-4-11(19)6-20-15(9)10/h1-4,6-8H,5H2,(H,23,25)(H,21,22,24) BCGBIDASILDMGN-UHFFFAOYSA-N 351658 N-(4-bromo-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(3-fluoroquinolin-8-yl)acetamide::US9796706, Compound 102 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351658&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636671 386046073 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695881 FC(F)(F)c1ccc2n(CC(=O)Nc3sc(Cl)cc3-c3ncn[nH]3)c(=O)ccc2c1 InChI=1S/C18H11ClF3N5O2S/c19-13-6-11(16-23-8-24-26-16)17(30-13)25-14(28)7-27-12-3-2-10(18(20,21)22)5-9(12)1-4-15(27)29/h1-6,8H,7H2,(H,25,28)(H,23,24,26) OENXBQLBKOLTFG-UHFFFAOYSA-N 351659 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethoxy)quinolin-1(2H)-yl)acetamide::US9796706, Compound 103::US9796706, Compound 105 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351659&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636670 386046074 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695884 Clc1cc(c(NC(=O)Cc2cncc3ccccc23)s1)-c1ncn[nH]1 InChI=1S/C17H12ClN5OS/c18-14-6-13(16-20-9-21-23-16)17(25-14)22-15(24)5-11-8-19-7-10-3-1-2-4-12(10)11/h1-4,6-9H,5H2,(H,22,24)(H,20,21,23) FYMBYJPTZWMMFS-UHFFFAOYSA-N 351660 N-(4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(isoquinolin-4-yl)acetamide::US9796706, Compound 104 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351660&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 139208020 386046075 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695887 FC(F)(F)c1ccc2n(CC(=O)Nc3sc(Cl)cc3-c3ncn[nH]3)c(=O)ccc2c1 InChI=1S/C18H11ClF3N5O2S/c19-13-6-11(16-23-8-24-26-16)17(30-13)25-14(28)7-27-12-3-2-10(18(20,21)22)5-9(12)1-4-15(27)29/h1-6,8H,7H2,(H,25,28)(H,23,24,26) OENXBQLBKOLTFG-UHFFFAOYSA-N 351659 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethoxy)quinolin-1(2H)-yl)acetamide::US9796706, Compound 103::US9796706, Compound 105 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351659&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636670 386046074 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695890 Fc1cnc2cccc(CC(=O)Nc3scc(Br)c3-c3nc[nH]n3)c2c1 InChI=1S/C17H11BrFN5OS/c18-12-7-26-17(15(12)16-21-8-22-24-16)23-14(25)4-9-2-1-3-13-11(9)5-10(19)6-20-13/h1-3,5-8H,4H2,(H,23,25)(H,21,22,24) HDGJMVJJOYGVSR-UHFFFAOYSA-N 351662 N-(4-bromo-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(3-fluoroquinolin-5-yl)acetamide::US9796706, Compound 106 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351662&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56665245 386046076 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695893 FC(F)(F)c1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1 InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-5-10(18(20,21)22)3-1-9(12)2-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) UBEKWKCSOKGROP-UHFFFAOYSA-N 351596 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-7-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 107::US9796706, Compound 40 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351596&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869881 386046012 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695896 Brc1csc(NC(=O)Cn2c3cc(ccc3ccc2=O)C#N)c1-c1ncn[nH]1 InChI=1S/C18H11BrN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-5-10(6-20)1-2-11(13)3-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24) NKUVBRQPLJOWBI-UHFFFAOYSA-N 351664 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(7-cyano-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 108 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351664&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56672174 386046077 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695899 Brc1csc(NC(=O)Cc2cccc3ccncc23)c1-c1ncn[nH]1 InChI=1S/C17H12BrN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-11-3-1-2-10-4-5-19-7-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23) NMPFZTMEQBQEIF-UHFFFAOYSA-N 351665 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-8-yl)acetamide::US9796706, Compound 109 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351665&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68786765 386046078 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695902 Brc1csc(NC(=O)Cn2c3ccc(cc3ccc2=O)C#N)c1-c1ncn[nH]1 InChI=1S/C18H11BrN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-3-1-10(6-20)5-11(13)2-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24) KBJSPAOJLUYMQM-UHFFFAOYSA-N 351666 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-cyano-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 110 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351666&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56682210 386046079 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695905 Brc1csc(NC(=O)Cc2cccc3cccnc23)c1-c1ncn[nH]1 InChI=1S/C17H12BrN5OS/c18-12-8-25-17(14(12)16-20-9-21-23-16)22-13(24)7-11-4-1-3-10-5-2-6-19-15(10)11/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23) XDQIQEHRAQMIFH-UHFFFAOYSA-N 351667 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-8-yl)acetamide::US9796706, Compound 111 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351667&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68785247 386046080 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695907 FC(F)(F)c1cccc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc12 InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-1-2-10(18(20,21)22)9(12)4-5-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) PHDVAWAUKMHEJM-UHFFFAOYSA-N 351668 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-5-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 112 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351668&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56672173 386046081 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695910 FC(F)(F)c1ccc2N(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)C(=O)CCc2c1 InChI=1S/C18H13BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-2-10(18(20,21)22)5-9(12)1-4-14(27)29/h2-3,5,7-8H,1,4,6H2,(H,25,28)(H,23,24,26) GXNJVDPSUZYHFN-UHFFFAOYSA-N 351669 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 113 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351669&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636645 386046082 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695913 Cn1cnc(n1)-c1c(NC(=O)Cc2cccc3ncccc23)scc1C#N InChI=1S/C19H14N6OS/c1-25-11-22-18(24-25)17-13(9-20)10-27-19(17)23-16(26)8-12-4-2-6-15-14(12)5-3-7-21-15/h2-7,10-11H,8H2,1H3,(H,23,26) SAERSRIEVMNCAV-UHFFFAOYSA-N 351670 N-(4-cyano-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 114 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351670&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68784414 386046083 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695916 FC(F)(F)c1ccc2ccc(CC(=O)Nc3scc(Br)c3-c3nc[nH]n3)cc2n1 InChI=1S/C18H11BrF3N5OS/c19-11-7-29-17(15(11)16-23-8-24-27-16)26-14(28)6-9-1-2-10-3-4-13(18(20,21)22)25-12(10)5-9/h1-5,7-8H,6H2,(H,26,28)(H,23,24,27) IUKUVUSRFBFNQS-UHFFFAOYSA-N 351671 N-(4-bromo-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-(trifluoromethyl)quinolin-7-yl)acetamide::US9796706, Compound 115 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351671&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68786120 386046084 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695919 Fc1cc(CC(=O)Nc2scc(Br)c2-c2ncn[nH]2)c2cccnc2c1 InChI=1S/C17H11BrFN5OS/c18-12-7-26-17(15(12)16-21-8-22-24-16)23-14(25)5-9-4-10(19)6-13-11(9)2-1-3-20-13/h1-4,6-8H,5H2,(H,23,25)(H,21,22,24) NJZPPBSOOUXHEF-UHFFFAOYSA-N 351672 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(7-fluoroquinolin-5-yl)acetamide::US9796706, Compound 116 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351672&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56661802 386046085 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695922 FC(F)(F)c1cnc2cccc(CC(=O)Nc3scc(Br)c3-c3nc[nH]n3)c2c1 InChI=1S/C18H11BrF3N5OS/c19-12-7-29-17(15(12)16-24-8-25-27-16)26-14(28)4-9-2-1-3-13-11(9)5-10(6-23-13)18(20,21)22/h1-3,5-8H,4H2,(H,26,28)(H,24,25,27) FXBNFLKLXHFULB-UHFFFAOYSA-N 351673 N-(4-bromo-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(3-(trifluoromethyl)quinolin-5-yl)acetamide::US9796706, Compound 117 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351673&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56678888 386046086 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695925 Fc1ccc2ncccc2c1CC(=O)Nc1scc(Br)c1-c1ncn[nH]1 InChI=1S/C17H11BrFN5OS/c18-11-7-26-17(15(11)16-21-8-22-24-16)23-14(25)6-10-9-2-1-5-20-13(9)4-3-12(10)19/h1-5,7-8H,6H2,(H,23,25)(H,21,22,24) SNHWMGRNLLJWJV-UHFFFAOYSA-N 351674 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-fluoroquinolin-5-yl)acetamide::US9796706, Compound 118 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351674&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68787520 386046087 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695928 Fc1cc2cccnc2cc1CC(=O)Nc1scc(Br)c1-c1ncn[nH]1 InChI=1S/C17H11BrFN5OS/c18-11-7-26-17(15(11)16-21-8-22-24-16)23-14(25)6-10-5-13-9(4-12(10)19)2-1-3-20-13/h1-5,7-8H,6H2,(H,23,25)(H,21,22,24) WASYKACWTDBGKU-UHFFFAOYSA-N 351675 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-fluoroquinolin-7-yl)acetamide::US9796706, Compound 119 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351675&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68786014 386046088 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695931 Brc1csc(NC(=O)Cn2c3ccc(cc3ccc2=O)C#C)c1-c1ncn[nH]1 InChI=1S/C19H12BrN5O2S/c1-2-11-3-5-14-12(7-11)4-6-16(27)25(14)8-15(26)23-19-17(13(20)9-28-19)18-21-10-22-24-18/h1,3-7,9-10H,8H2,(H,23,26)(H,21,22,24) PQXQYLAXUMZODS-UHFFFAOYSA-N 351676 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-ethynyl-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 120 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351676&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636680 386046089 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695934 FC(F)(F)c1cc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2cn1 InChI=1S/C17H10BrF3N6O2S/c18-9-6-30-16(14(9)15-23-7-24-26-15)25-12(28)5-27-10-3-11(17(19,20)21)22-4-8(10)1-2-13(27)29/h1-4,6-7H,5H2,(H,25,28)(H,23,24,26) YSSREBGNECUESU-UHFFFAOYSA-N 351677 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-7-(trifluoromethyl)-1,6-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 121 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351677&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56665246 386046090 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695937 Brc1csc(NC(=O)Cn2c3ccnn3ccc2=O)c1-c1ncn[nH]1 InChI=1S/C14H10BrN7O2S/c15-8-6-25-14(12(8)13-16-7-17-20-13)19-9(23)5-21-10-1-3-18-22(10)4-2-11(21)24/h1-4,6-7H,5H2,(H,19,23)(H,16,17,20) LMZRJJTWTQNOEI-UHFFFAOYSA-N 351678 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(5-oxopyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetamide::US9796706, Compound 122 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351678&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 76389033 386046091 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695940 FC(F)(F)c1cnc2c(CC(=O)Nc3scc(Br)c3-c3nc[nH]n3)cccc2c1 InChI=1S/C18H11BrF3N5OS/c19-12-7-29-17(14(12)16-24-8-25-27-16)26-13(28)5-10-3-1-2-9-4-11(18(20,21)22)6-23-15(9)10/h1-4,6-8H,5H2,(H,26,28)(H,24,25,27) CFYORNVESCIBFR-UHFFFAOYSA-N 351679 N-(4-bromo-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(3-(trifluoromethyl)quinolin-8-yl)acetamide::US9796706, Compound 123 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351679&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636681 386046092 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695943 Cc1cn2c(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)csc2n1 InChI=1S/C14H11BrN6OS2/c1-7-3-21-8(4-24-14(21)18-7)2-10(22)19-13-11(9(15)5-23-13)12-16-6-17-20-12/h3-6H,2H2,1H3,(H,19,22)(H,16,17,20) BPISHBULNJGTSV-UHFFFAOYSA-N 351680 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-methylimidazo[2,1-b]thiazol-3-yl)acetamide::US9796706, Compound 124 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351680&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68785158 386046093 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695946 FC(F)(F)c1ccc2n(CC(=O)Nc3ccsc3-c3cscn3)c(=O)ccc2c1 InChI=1S/C19H12F3N3O2S2/c20-19(21,22)12-2-3-15-11(7-12)1-4-17(27)25(15)8-16(26)24-13-5-6-29-18(13)14-9-28-10-23-14/h1-7,9-10H,8H2,(H,24,26) NOWOTULLJWYTDW-UHFFFAOYSA-N 351681 2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide::US9796706, Compound 125 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351681&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68784811 386046094 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695949 O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1cnccn1 InChI=1S/C20H13N5OS/c21-10-14-12-27-20(19(14)17-11-22-7-8-24-17)25-18(26)9-13-3-1-5-16-15(13)4-2-6-23-16/h1-8,11-12H,9H2,(H,25,26) OIWWCBDLNQMJED-UHFFFAOYSA-N 351682 N-(4-cyano-3-(pyrazin-2-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 126 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351682&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636653 386046095 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695952 O=C(Cn1c2ccncc2ccc1=O)Nc1ccsc1-c1cscn1 InChI=1S/C17H12N4O2S2/c22-15(20-12-4-6-25-17(12)13-9-24-10-19-13)8-21-14-3-5-18-7-11(14)1-2-16(21)23/h1-7,9-10H,8H2,(H,20,22) CUOATQPCWKTSBZ-UHFFFAOYSA-N 351683 2-(2-oxo-1,6-naphthyridin-1(2H)-yl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide::US9796706, Compound 127 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351683&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68783462 386046096 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695955 FC1(F)C(=O)N(CC(=O)Nc2scc(Br)c2-c2nnc[nH]2)c2ccccc12 InChI=1S/C16H10BrF2N5O2S/c17-9-6-27-14(12(9)13-20-7-21-23-13)22-11(25)5-24-10-4-2-1-3-8(10)16(18,19)15(24)26/h1-4,6-7H,5H2,(H,22,25)(H,20,21,23) QVTKXADFSYUCCL-UHFFFAOYSA-N 351684 N-(4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(3,3-difluoro-2-oxoindolin-1-yl)acetamide::US9796706, Compound 128 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351684&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636650 386046097 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695958 Brc1csc(NC(=O)Cc2cccc3ncsc23)c1-c1ncn[nH]1 InChI=1S/C15H10BrN5OS2/c16-9-5-23-15(12(9)14-17-6-19-21-14)20-11(22)4-8-2-1-3-10-13(8)24-7-18-10/h1-3,5-7H,4H2,(H,20,22)(H,17,19,21) YIGNJZNNUDBISO-UHFFFAOYSA-N 351685 2-(benzo[d]thiazol-7-yl)-N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)acetamide::US9796706, Compound 129 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351685&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68784884 386046098 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695961 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Cl)c3-c3ncn[nH]3)c(=O)ccc2c1 InChI=1S/C18H11ClF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-2-10(18(20,21)22)5-9(12)1-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) WMLODNBRBQZVGS-UHFFFAOYSA-N 351686 N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 130 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351686&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68782656 386046099 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695964 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3ncco3)c(=O)ccc2c1 InChI=1S/C20H11F3N4O3S/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) ZLFCYABKBKXJOL-UHFFFAOYSA-N 50352626 CHEMBL1822307::US9796706, Compound 131 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56675421 136359312 CHEMBL1822307 ZINC72181609 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695967 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2n1 InChI=1S/C17H10BrF3N6O2S/c18-8-6-30-16(14(8)15-22-7-23-26-15)25-12(28)5-27-10-2-3-11(17(19,20)21)24-9(10)1-4-13(27)29/h1-4,6-7H,5H2,(H,25,28)(H,22,23,26) UCRSZQFDYBPHLJ-UHFFFAOYSA-N 351688 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 132 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351688&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869491 386046101 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695970 Fc1cc2ccc(=O)n(CC(=O)Nc3sccc3-c3ncon3)c2cc1F InChI=1S/C17H10F2N4O3S/c18-11-5-9-1-2-15(25)23(13(9)6-12(11)19)7-14(24)21-17-10(3-4-27-17)16-20-8-26-22-16/h1-6,8H,7H2,(H,21,24) HGLFQPWRBDPMCI-UHFFFAOYSA-N 351689 N-(3-(1,2,4-oxadiazol-3-yl)thiophen-2-yl)-2-(6,7-difluoro-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 133 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351689&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869492 386046102 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695973 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3nccs3)c(=O)ccc2c1 InChI=1S/C20H11F3N4O2S2/c21-20(22,23)13-2-3-14-11(7-13)1-4-16(29)27(14)9-15(28)26-19-17(12(8-24)10-31-19)18-25-5-6-30-18/h1-7,10H,9H2,(H,26,28) ACDQVXJNZDLXFP-UHFFFAOYSA-N 50352627 CHEMBL1822308::US9796706, Compound 134 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869490 136359313 CHEMBL1822308 ZINC72181610 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695976 FC(F)(F)c1cc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccn2n1 InChI=1S/C15H9BrF3N7O2S/c16-7-5-29-14(12(7)13-20-6-21-23-13)22-9(27)4-25-10-3-8(15(17,18)19)24-26(10)2-1-11(25)28/h1-3,5-6H,4H2,(H,22,27)(H,20,21,23) SYSMFXCWULAWTA-UHFFFAOYSA-N 351691 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(5-oxo-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetamide::US9796706, Compound 135 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351691&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 75237863 386046104 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695979 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3cscn3)c(=O)ccc2c1 InChI=1S/C20H11F3N4O2S2/c21-20(22,23)13-2-3-15-11(5-13)1-4-17(29)27(15)7-16(28)26-19-18(12(6-24)8-31-19)14-9-30-10-25-14/h1-5,8-10H,7H2,(H,26,28) IRABIGXKJCMNIG-UHFFFAOYSA-N 50352628 CHEMBL1822309::US9796706, Compound 136 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352628&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56665093 136359314 CHEMBL1822309 ZINC72181483 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695982 Brc1csc(NC(=O)Cc2cccc3nccn23)c1-c1ncn[nH]1 InChI=1S/C15H11BrN6OS/c16-10-7-24-15(13(10)14-18-8-19-21-14)20-12(23)6-9-2-1-3-11-17-4-5-22(9)11/h1-5,7-8H,6H2,(H,20,23)(H,18,19,21) MVCRNZBBKVSUMF-UHFFFAOYSA-N 351693 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(imidazo[1,2-a]pyridin-5-yl)acetamide::US9796706, Compound 137 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351693&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636658 386046106 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695985 Fc1cc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2cc1C(F)(F)F InChI=1S/C18H10BrF4N5O2S/c19-10-6-31-17(15(10)16-24-7-25-27-16)26-13(29)5-28-12-4-11(20)9(18(21,22)23)3-8(12)1-2-14(28)30/h1-4,6-7H,5H2,(H,26,29)(H,24,25,27) DVERYUKMFTUKPD-UHFFFAOYSA-N 351694 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(7-fluoro-2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 138 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351694&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636635 386046107 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695988 Cn1cnc(n1)-c1c(Br)csc1NC(=O)CN1C(=O)CCc2ncccc12 InChI=1S/C17H15BrN6O2S/c1-23-9-20-16(22-23)15-10(18)8-27-17(15)21-13(25)7-24-12-3-2-6-19-11(12)4-5-14(24)26/h2-3,6,8-9H,4-5,7H2,1H3,(H,21,25) RDFFZPKZBXFQEF-UHFFFAOYSA-N 50352624 CHEMBL1822305::US9796706, Compound 139 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352624&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56665092 136359310 CHEMBL1822305 ZINC72181730 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695991 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-c3cncs3)c(=O)ccc2c1 InChI=1S/C20H11F3N4O2S2/c21-20(22,23)13-2-3-14-11(5-13)1-4-17(29)27(14)8-16(28)26-19-18(12(6-24)9-30-19)15-7-25-10-31-15/h1-5,7,9-10H,8H2,(H,26,28) HIYYFEOHAYFRAI-UHFFFAOYSA-N 351696 N-(4-cyano-3-(thiazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 140 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351696&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636675 386046109 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695994 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-n3ccnn3)c(=O)ccc2c1 InChI=1S/C19H11F3N6O2S/c20-19(21,22)13-2-3-14-11(7-13)1-4-16(30)27(14)9-15(29)25-18-17(12(8-23)10-31-18)28-6-5-24-26-28/h1-7,10H,9H2,(H,25,29) SOYZWFHIQDLKRP-UHFFFAOYSA-N 351697 N-(4-cyano-3-(1H-1,2,3-triazol-1-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 141 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351697&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636652 386046110 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695997 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-n3nnc4ccccc34)c(=O)ccc2c1 InChI=1S/C23H13F3N6O2S/c24-23(25,26)15-6-7-17-13(9-15)5-8-20(34)31(17)11-19(33)28-22-21(14(10-27)12-35-22)32-18-4-2-1-3-16(18)29-30-32/h1-9,12H,11H2,(H,28,33) KYKNBGVEGQTCEP-UHFFFAOYSA-N 351698 N-(3-(1H-benzo[d][1,2,3]triazol-1-yl)-4-cyanothiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 142 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351698&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68785099 386046111 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696000 Fc1cc2ccncc2cc1CC(=O)Nc1scc(Br)c1-n1nccn1 InChI=1S/C17H11BrFN5OS/c18-13-9-26-17(16(13)24-21-3-4-22-24)23-15(25)7-11-5-12-8-20-2-1-10(12)6-14(11)19/h1-6,8-9H,7H2,(H,23,25) COQWMWFIUDZZHB-UHFFFAOYSA-N 351699 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-fluoroisoquinolin-7-yl)acetamide::US9796706, Compound 143 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351699&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 139208021 386046112 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696003 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(C#N)c3-n3nccn3)c(=O)ccc2c1 InChI=1S/C19H11F3N6O2S/c20-19(21,22)13-2-3-14-11(7-13)1-4-16(30)27(14)9-15(29)26-18-17(12(8-23)10-31-18)28-24-5-6-25-28/h1-7,10H,9H2,(H,26,29) VKRUCARSBLGSRQ-UHFFFAOYSA-N 351700 N-(4-cyano-3-(2H-1,2,3-triazol-2-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 144 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351700&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636656 386046113 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696006 Clc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1nc[nH]n1 InChI=1S/C16H13ClN6O2S/c17-9-7-26-16(14(9)15-19-8-20-22-15)21-12(24)6-23-11-2-1-5-18-10(11)3-4-13(23)25/h1-2,5,7-8H,3-4,6H2,(H,21,24)(H,19,20,22) DCNGIZIERIJJPQ-UHFFFAOYSA-N 351701 N-(4-chloro-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 145 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351701&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68755556 386046114 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696009 O=C(CN1C(=O)CCc2ncccc12)Nc1scc(C#N)c1-c1nccs1 InChI=1S/C18H13N5O2S2/c19-8-11-10-27-18(16(11)17-21-6-7-26-17)22-14(24)9-23-13-2-1-5-20-12(13)3-4-15(23)25/h1-2,5-7,10H,3-4,9H2,(H,22,24) HWQRBIQRGAZWGS-UHFFFAOYSA-N 50352625 CHEMBL1822306::US9796706, Compound 146 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352625&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56658171 136359311 CHEMBL1822306 ZINC72181608 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696012 Cn1cnc(n1)-c1c(Cl)csc1NC(=O)CN1C(=O)CCc2ncccc12 InChI=1S/C17H15ClN6O2S/c1-23-9-20-16(22-23)15-10(18)8-27-17(15)21-13(25)7-24-12-3-2-6-19-11(12)4-5-14(24)26/h2-3,6,8-9H,4-5,7H2,1H3,(H,21,25) ILHRAMYLBYYPFM-UHFFFAOYSA-N 351703 N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 147 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351703&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636662 386046116 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696015 Clc1csc(NC(=O)Cn2c3ccnn3ccc2=O)c1-c1ncn[nH]1 InChI=1S/C14H10ClN7O2S/c15-8-6-25-14(12(8)13-16-7-17-20-13)19-9(23)5-21-10-1-3-18-22(10)4-2-11(21)24/h1-4,6-7H,5H2,(H,19,23)(H,16,17,20) VMHCBGRDJDGZRY-UHFFFAOYSA-N 351704 N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(5-oxopyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetamide::US9796706, Compound 148 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351704&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 77567582 386046117 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696018 Brc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1ncco1 InChI=1S/C17H13BrN4O3S/c18-10-9-26-17(15(10)16-20-6-7-25-16)21-13(23)8-22-12-2-1-5-19-11(12)3-4-14(22)24/h1-2,5-7,9H,3-4,8H2,(H,21,23) AEIKXFACENTHCD-UHFFFAOYSA-N 50352622 CHEMBL1822153::US9796706, Compound 149 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352622&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56672175 136359308 CHEMBL1822153 ZINC72179292 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696021 Brc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1nccs1 InChI=1S/C17H13BrN4O2S2/c18-10-9-26-17(15(10)16-20-6-7-25-16)21-13(23)8-22-12-2-1-5-19-11(12)3-4-14(22)24/h1-2,5-7,9H,3-4,8H2,(H,21,23) IUGSVSMCSCKMLY-UHFFFAOYSA-N 50352623 CHEMBL1822154::US9796706, Compound 150 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352623&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 56668539 136359309 CHEMBL1822154 ZINC72181085 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696024 Clc1csc(NC(=O)CN2C(=O)CCc3ncccc23)c1-c1nccs1 InChI=1S/C17H13ClN4O2S2/c18-10-9-26-17(15(10)16-20-6-7-25-16)21-13(23)8-22-12-2-1-5-19-11(12)3-4-14(22)24/h1-2,5-7,9H,3-4,8H2,(H,21,23) CCJKPOXBPYUZOT-UHFFFAOYSA-N 351707 N-(4-chloro-3-(thiazol-2-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 151 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351707&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636679 386046120 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696027 O=C(CN1C(=O)CCc2ncccc12)Nc1scc(C#N)c1-c1nc2ccccc2s1 InChI=1S/C22H15N5O2S2/c23-10-13-12-30-21(20(13)22-25-15-4-1-2-6-17(15)31-22)26-18(28)11-27-16-5-3-9-24-14(16)7-8-19(27)29/h1-6,9,12H,7-8,11H2,(H,26,28) GCLBJPIXOCEIAW-UHFFFAOYSA-N 351708 N-(3-(benzo[d]thiazol-2-yl)-4-cyanothiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 152 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351708&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68785921 386046121 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696030 Cc1n[nH]c(n1)-c1c(Cl)csc1NC(=O)CN1C(=O)CCc2ncccc12 InChI=1S/C17H15ClN6O2S/c1-9-20-16(23-22-9)15-10(18)8-27-17(15)21-13(25)7-24-12-3-2-6-19-11(12)4-5-14(24)26/h2-3,6,8H,4-5,7H2,1H3,(H,21,25)(H,20,22,23) BUTLRWZSIRPHBD-UHFFFAOYSA-N 351709 N-(4-chloro-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 153 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351709&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68785300 386046122 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696033 CN(C)CCCn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2ccc(cc2ccc1=O)C(F)(F)F InChI=1S/C23H22ClF3N6O2S/c1-31(2)8-3-9-32-13-28-21(30-32)20-16(24)12-36-22(20)29-18(34)11-33-17-6-5-15(23(25,26)27)10-14(17)4-7-19(33)35/h4-7,10,12-13H,3,8-9,11H2,1-2H3,(H,29,34) VVCXMAPEYLRREJ-UHFFFAOYSA-N 351710 N-(4-chloro-3-(1-(3-(dimethylamino)propyl)-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 154 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351710&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869226 386046123 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696036 CN1CCN(CCCn2cnc(n2)-c2c(Cl)csc2NC(=O)Cn2c3ccc(cc3ccc2=O)C(F)(F)F)CC1 InChI=1S/C26H27ClF3N7O2S/c1-34-9-11-35(12-10-34)7-2-8-36-16-31-24(33-36)23-19(27)15-40-25(23)32-21(38)14-37-20-5-4-18(26(28,29)30)13-17(20)3-6-22(37)39/h3-6,13,15-16H,2,7-12,14H2,1H3,(H,32,38) FQYOPPJOQQVLDN-UHFFFAOYSA-N 351711 N-(4-chloro-3-(1-(3-(4-methylpiperazin-1-yl)propyl)-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 155 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351711&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869227 386046124 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696039 CCc1n[nH]c(n1)-c1c(Cl)csc1NC(=O)CN1C(=O)CCc2ncccc12 InChI=1S/C18H17ClN6O2S/c1-2-13-21-17(24-23-13)16-10(19)9-28-18(16)22-14(26)8-25-12-4-3-7-20-11(12)5-6-15(25)27/h3-4,7,9H,2,5-6,8H2,1H3,(H,22,26)(H,21,23,24) TXGOJXMPRGYDNN-UHFFFAOYSA-N 351712 N-(4-chloro-3-(3-ethyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 156 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351712&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869287 386046125 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696042 CN(C)CCn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2ccc(cc2ccc1=O)C(F)(F)F InChI=1S/C22H20ClF3N6O2S/c1-30(2)7-8-31-12-27-20(29-31)19-15(23)11-35-21(19)28-17(33)10-32-16-5-4-14(22(24,25)26)9-13(16)3-6-18(32)34/h3-6,9,11-12H,7-8,10H2,1-2H3,(H,28,33) JFLZYXQEUITDDU-UHFFFAOYSA-N 351713 N-(4-chloro-3-(1-(2-(dimethylamino)ethyl)-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 157 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351713&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869288 386046126 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696045 CN(C)CCN(C(=O)Cn1c2ccc(cc2ccc1=O)C(F)(F)F)c1scc(Cl)c1-c1nc[nH]n1 InChI=1S/C22H20ClF3N6O2S/c1-30(2)7-8-31(21-19(15(23)11-35-21)20-27-12-28-29-20)18(34)10-32-16-5-4-14(22(24,25)26)9-13(16)3-6-17(32)33/h3-6,9,11-12H,7-8,10H2,1-2H3,(H,27,28,29) PNBNDCZVZPEMJZ-UHFFFAOYSA-N 351714 N-(4-chloro-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-N-(2-(dimethylamino)ethyl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 158 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351714&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869228 386046127 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696048 O=C(CN1C(=O)CCc2ncccc12)Nc1scc(C#N)c1-c1nc[nH]n1 InChI=1S/C17H13N7O2S/c18-6-10-8-27-17(15(10)16-20-9-21-23-16)22-13(25)7-24-12-2-1-5-19-11(12)3-4-14(24)26/h1-2,5,8-9H,3-4,7H2,(H,22,25)(H,20,21,23) ZZGXJNUHZVCAOW-UHFFFAOYSA-N 351715 N-(4-cyano-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 159 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351715&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869285 386046128 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696051 Cn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2ccnn2ccc1=O InChI=1S/C15H12ClN7O2S/c1-21-8-17-14(20-21)13-9(16)7-26-15(13)19-10(24)6-22-11-2-4-18-23(11)5-3-12(22)25/h2-5,7-8H,6H2,1H3,(H,19,24) GRDXPCQIFCSUNV-UHFFFAOYSA-N 351716 N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(5-oxopyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetamide::US9796706, Compound 160 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351716&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 77553436 386046129 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696054 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Cl)c3-c3ncn(CCCN4CCOCC4)n3)c(=O)ccc2c1 InChI=1S/C25H24ClF3N6O3S/c26-18-14-39-24(22(18)23-30-15-34(32-23)7-1-6-33-8-10-38-11-9-33)31-20(36)13-35-19-4-3-17(25(27,28)29)12-16(19)2-5-21(35)37/h2-5,12,14-15H,1,6-11,13H2,(H,31,36) UCCWRYUBEGWTHC-UHFFFAOYSA-N 351717 N-(4-chloro-3-(1-(3-morpholinopropyl)-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 161 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351717&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869289 386046130 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696057 FC(F)(F)c1ccc2n(CC(=O)N(CCCN3CCCC3)c3scc(Cl)c3-c3nc[nH]n3)c(=O)ccc2c1 InChI=1S/C25H24ClF3N6O2S/c26-18-14-38-24(22(18)23-30-15-31-32-23)34(11-3-10-33-8-1-2-9-33)21(37)13-35-19-6-5-17(25(27,28)29)12-16(19)4-7-20(35)36/h4-7,12,14-15H,1-3,8-11,13H2,(H,30,31,32) YQKRHVPNSQGZRH-UHFFFAOYSA-N 351718 N-(4-chloro-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)-N-(3-(pyrrolidin-1-yl)propyl)acetamide::US9796706, Compound 162 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351718&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869351 386046131 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696060 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Cl)c3-c3ncn(CCCN4CCCC4)n3)c(=O)ccc2c1 InChI=1S/C25H24ClF3N6O2S/c26-18-14-38-24(22(18)23-30-15-34(32-23)11-3-10-33-8-1-2-9-33)31-20(36)13-35-19-6-5-17(25(27,28)29)12-16(19)4-7-21(35)37/h4-7,12,14-15H,1-3,8-11,13H2,(H,31,36) PWODXIIHLFKKKG-UHFFFAOYSA-N 351719 N-(4-chloro-3-(1-(3-(pyrrolidin-1-yl)propyl)-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 163 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351719&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869352 386046132 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696063 Cn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2ccc(nc2ccc1=O)C(F)(F)F InChI=1S/C18H12ClF3N6O2S/c1-27-8-23-16(26-27)15-9(19)7-31-17(15)25-13(29)6-28-11-3-4-12(18(20,21)22)24-10(11)2-5-14(28)30/h2-5,7-8H,6H2,1H3,(H,25,29) IHBGYIDLKZNUCI-UHFFFAOYSA-N 351720 N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 164 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351720&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869353 386046133 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696066 FC(F)(F)c1ccc(CC(=O)Nc2scc(Cl)c2-c2ncn[nH]2)c2cccnc12 InChI=1S/C18H11ClF3N5OS/c19-12-7-29-17(14(12)16-24-8-25-27-16)26-13(28)6-9-3-4-11(18(20,21)22)15-10(9)2-1-5-23-15/h1-5,7-8H,6H2,(H,26,28)(H,24,25,27) RLMPNZZDUJOQQE-UHFFFAOYSA-N 351721 N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(8-(trifluoromethyl)quinolin-5-yl)acetamide::US9796706, Compound 165 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351721&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869290 386046134 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696069 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Br)c3-n3nccn3)c(=O)ccc2c1 InChI=1S/C18H11BrF3N5O2S/c19-12-9-30-17(16(12)27-23-5-6-24-27)25-14(28)8-26-13-3-2-11(18(20,21)22)7-10(13)1-4-15(26)29/h1-7,9H,8H2,(H,25,28) PDONIOWRUVYDDX-UHFFFAOYSA-N 351722 N-(4-bromo-3-(2H-1,2,3-triazol-2-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 166 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351722&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869354 386046135 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696072 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Cl)c3-c3ncn[nH]3)c(=O)ccc2n1 InChI=1S/C17H10ClF3N6O2S/c18-8-6-30-16(14(8)15-22-7-23-26-15)25-12(28)5-27-10-2-3-11(17(19,20)21)24-9(10)1-4-13(27)29/h1-4,6-7H,5H2,(H,25,28)(H,22,23,26) OMWAZFXKROFRDC-UHFFFAOYSA-N 351723 N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 167 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351723&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869286 386046136 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696075 CC(C)c1n[nH]c(n1)-c1c(Cl)csc1NC(=O)CN1C(=O)CCc2ncccc12 InChI=1S/C19H19ClN6O2S/c1-10(2)17-23-18(25-24-17)16-11(20)9-29-19(16)22-14(27)8-26-13-4-3-7-21-12(13)5-6-15(26)28/h3-4,7,9-10H,5-6,8H2,1-2H3,(H,22,27)(H,23,24,25) DADCXVXYKJUAMC-UHFFFAOYSA-N 351724 N-(4-chloro-3-(3-isopropyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 168 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351724&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869427 386046137 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696078 Brc1csc(NC(=O)Cn2c3ccc(Br)cc3ccc2=O)c1-c1nc[nH]n1 InChI=1S/C17H11Br2N5O2S/c18-10-2-3-12-9(5-10)1-4-14(26)24(12)6-13(25)22-17-15(11(19)7-27-17)16-20-8-21-23-16/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23) IQDXJAIBXFSFTF-UHFFFAOYSA-N 351725 2-(6-bromo-2-oxoquinolin-1(2H)-yl)-N-(4-bromo-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)acetamide::US9796706, Compound 169 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351725&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869426 386046138 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696081 Cn1cnc(n1)-c1c(NC(=O)CN2C(=O)CCc3ncccc23)scc1C#N InChI=1S/C18H15N7O2S/c1-24-10-21-17(23-24)16-11(7-19)9-28-18(16)22-14(26)8-25-13-3-2-6-20-12(13)4-5-15(25)27/h2-3,6,9-10H,4-5,8H2,1H3,(H,22,26) WSIIIFVUEOYCLR-UHFFFAOYSA-N 351726 N-(4-cyano-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 170 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351726&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869423 386046139 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696084 Clc1csc(NC(=O)Cn2c3ccc(Br)cc3ccc2=O)c1-c1nc[nH]n1 InChI=1S/C17H11BrClN5O2S/c18-10-2-3-12-9(5-10)1-4-14(26)24(12)6-13(25)22-17-15(11(19)7-27-17)16-20-8-21-23-16/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23) FBZIOKFEKUWDKW-UHFFFAOYSA-N 351727 2-(6-bromo-2-oxoquinolin-1(2H)-yl)-N-(4-chloro-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)acetamide::US9796706, Compound 171 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351727&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869356 386046140 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696087 Clc1csc(NC(=O)Cn2c3ccc(cc3ccc2=O)C#N)c1-c1nc[nH]n1 InChI=1S/C18H11ClN6O2S/c19-12-8-28-18(16(12)17-21-9-22-24-17)23-14(26)7-25-13-3-1-10(6-20)5-11(13)2-4-15(25)27/h1-5,8-9H,7H2,(H,23,26)(H,21,22,24) KTVXZCIIWRUNCE-UHFFFAOYSA-N 351728 N-(4-chloro-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(6-cyano-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 172 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351728&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869425 386046141 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696090 FC(F)(F)c1cc2n(CC(=O)Nc3scc(Cl)c3-c3ncn[nH]3)c(=O)ccn2n1 InChI=1S/C15H9ClF3N7O2S/c16-7-5-29-14(12(7)13-20-6-21-23-13)22-9(27)4-25-10-3-8(15(17,18)19)24-26(10)2-1-11(25)28/h1-3,5-6H,4H2,(H,22,27)(H,20,21,23) YDANRHXDQLFVJA-UHFFFAOYSA-N 351729 N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(5-oxo-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetamide::US9796706, Compound 173 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351729&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 75237772 386046142 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696093 FC(F)(F)c1cc2n(CC(=O)Nc3scc(Cl)c3-c3nc[nH]n3)c(=O)ccc2cn1 InChI=1S/C17H10ClF3N6O2S/c18-9-6-30-16(14(9)15-23-7-24-26-15)25-12(28)5-27-10-3-11(17(19,20)21)22-4-8(10)1-2-13(27)29/h1-4,6-7H,5H2,(H,25,28)(H,23,24,26) PLFQWYCMTKILEG-UHFFFAOYSA-N 351730 N-(4-chloro-3-(1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-7-(trifluoromethyl)-1,6-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 174 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351730&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869428 386046143 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696096 Cn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2cc(nn2ccc1=O)C(F)(F)F InChI=1S/C16H11ClF3N7O2S/c1-25-7-21-14(24-25)13-8(17)6-30-15(13)22-10(28)5-26-11-4-9(16(18,19)20)23-27(11)3-2-12(26)29/h2-4,6-7H,5H2,1H3,(H,22,28) SJQZGOJOGORHFG-UHFFFAOYSA-N 351731 N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(5-oxo-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-4(5H)-yl)acetamide::US9796706, Compound 175 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351731&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 75237819 386046144 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 696099 Cn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2cc(ncc2ccc1=O)C(F)(F)F InChI=1S/C18H12ClF3N6O2S/c1-27-8-24-16(26-27)15-10(19)7-31-17(15)25-13(29)6-28-11-4-12(18(20,21)22)23-5-9(11)2-3-14(28)30/h2-5,7-8H,6H2,1H3,(H,25,29) GNOUFYLAXAIVPV-UHFFFAOYSA-N 351732 N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-7-(trifluoromethyl)-1,6-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 176 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351732&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68785972 386046145 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695597 O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1ncn[nH]1 InChI=1S/C18H14N4OS/c23-16(10-13-6-3-5-12-4-1-2-7-14(12)13)21-15-8-9-24-17(15)18-19-11-20-22-18/h1-9,11H,10H2,(H,21,23)(H,19,20,22) FKBQPAXZYUEULP-UHFFFAOYSA-N 351557 N-(2-(1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 1 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351557&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52948519 386045974 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695600 Cc1n[nH]c(n1)-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C19H16N4OS/c1-12-20-19(23-22-12)18-16(9-10-25-18)21-17(24)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,21,24)(H,20,22,23) JIZAXYFIPHHWDF-UHFFFAOYSA-N 351558 N-(2-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 2 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351558&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869611 386045975 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695603 Cc1nc(-c2sccc2NC(=O)Cc2cccc3ccccc23)n(C)n1 InChI=1S/C20H18N4OS/c1-13-21-20(24(2)23-13)19-17(10-11-26-19)22-18(25)12-15-8-5-7-14-6-3-4-9-16(14)15/h3-11H,12H2,1-2H3,(H,22,25) GMDHUVZYMRKGIE-UHFFFAOYSA-N 50332074 CHEMBL1287975::N-(2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 3 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332074&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869609 123111189 CHEMBL1287975 ZINC64235697 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695605 COc1ccc(CC(=O)Nc2ccsc2-c2nc(C)n[nH]2)cc1 InChI=1S/C16H16N4O2S/c1-10-17-16(20-19-10)15-13(7-8-23-15)18-14(21)9-11-3-5-12(22-2)6-4-11/h3-8H,9H2,1-2H3,(H,18,21)(H,17,19,20) QBCIOLOPSHLJAD-UHFFFAOYSA-N 351560 2-(4-methoxyphenyl)-N-(2-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)acetamide::US9796706, Compound 4 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351560&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869608 386045977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695608 COc1ccc(CC(=O)Nc2ccsc2-c2ncn[nH]2)cc1 InChI=1S/C15H14N4O2S/c1-21-11-4-2-10(3-5-11)8-13(20)18-12-6-7-22-14(12)15-16-9-17-19-15/h2-7,9H,8H2,1H3,(H,18,20)(H,16,17,19) MJJSUPSTKXMINR-UHFFFAOYSA-N 351561 N-(2-(1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 5 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351561&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869612 386045978 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695611 COc1ccc(CC(=O)Nc2ccsc2-n2cncn2)cc1 InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)8-14(20)18-13-6-7-22-15(13)19-10-16-9-17-19/h2-7,9-10H,8H2,1H3,(H,18,20) BEVYWBNCINQJQH-UHFFFAOYSA-N 50332076 CHEMBL1288005::N-(2-(1H-1,2,4-triazol-1-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 6 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332076&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869671 123111191 CHEMBL1288005 ZINC64559153 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695613 COc1ccc(CC(=O)Nc2scc(C)c2-c2nc(C)n[nH]2)cc1 InChI=1S/C17H18N4O2S/c1-10-9-24-17(15(10)16-18-11(2)20-21-16)19-14(22)8-12-4-6-13(23-3)7-5-12/h4-7,9H,8H2,1-3H3,(H,19,22)(H,18,20,21) LXZLCVFQXWMBJR-UHFFFAOYSA-N 351563 2-(4-methoxyphenyl)-N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)acetamide::US9796706, Compound 7 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351563&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869672 386045980 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695616 COc1ccc(CC(=O)Nc2ccsc2-n2nccn2)cc1 InChI=1S/C15H14N4O2S/c1-21-12-4-2-11(3-5-12)10-14(20)18-13-6-9-22-15(13)19-16-7-8-17-19/h2-9H,10H2,1H3,(H,18,20) KHIAZVHADWMRSJ-UHFFFAOYSA-N 50332077 CHEMBL1288006::N-(2-(2H-1,2,3-triazol-2-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 8 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332077&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869677 123111192 CHEMBL1288006 ZINC64560442 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695619 COc1ccc(CC(=O)Nc2ccsc2-c2nc(n[nH]2)C2CC2)cc1 InChI=1S/C18H18N4O2S/c1-24-13-6-2-11(3-7-13)10-15(23)19-14-8-9-25-16(14)18-20-17(21-22-18)12-4-5-12/h2-3,6-9,12H,4-5,10H2,1H3,(H,19,23)(H,20,21,22) ODHKMJDWABDYHD-UHFFFAOYSA-N 351565 N-(2-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 9 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351565&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59636646 386045982 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695622 CCc1n[nH]c(n1)-c1sccc1NC(=O)Cc1ccc(OC)cc1 InChI=1S/C17H18N4O2S/c1-3-14-19-17(21-20-14)16-13(8-9-24-16)18-15(22)10-11-4-6-12(23-2)7-5-11/h4-9H,3,10H2,1-2H3,(H,18,22)(H,19,20,21) JZBWNCDUGYMBRE-UHFFFAOYSA-N 351566 N-(2-(3-ethyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 10 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351566&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869676 386045983 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695625 COc1ccc(CC(=O)Nc2ccsc2-c2nc(n[nH]2)C(C)(C)C)cc1 InChI=1S/C19H22N4O2S/c1-19(2,3)18-21-17(22-23-18)16-14(9-10-26-16)20-15(24)11-12-5-7-13(25-4)8-6-12/h5-10H,11H2,1-4H3,(H,20,24)(H,21,22,23) BCIFQWOEDQXXEQ-UHFFFAOYSA-N 351567 N-(2-(3-tert-butyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 11 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351567&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68787204 386045984 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695628 COc1ccc(CC(=O)Nc2ccsc2-c2nc(n[nH]2)C2CCCO2)cc1 351568 2-(4-methoxyphenyl)-N-(2-(3-(tetrahydrofuran-2-yl)-1H-1,2,4-triazol-5-yl)thiophen-3-yl)acetamide::US9796706, Compound 12 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351568&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869739 386045985 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695631 COc1ccc(CC(=O)Nc2ccsc2-c2nc(n[nH]2)C(F)(F)F)cc1 InChI=1S/C16H13F3N4O2S/c1-25-10-4-2-9(3-5-10)8-12(24)20-11-6-7-26-13(11)14-21-15(23-22-14)16(17,18)19/h2-7H,8H2,1H3,(H,20,24)(H,21,22,23) WKKHWEMTBODBGE-UHFFFAOYSA-N 351569 2-(4-methoxyphenyl)-N-(2-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)thiophen-3-yl)acetamide::US9796706, Compound 13 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351569&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869740 386045986 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695634 Cc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1ncn[nH]1 InChI=1S/C18H17N5O2S/c1-11-9-26-18(16(11)17-19-10-20-22-17)21-14(24)8-23-13-5-3-2-4-12(13)6-7-15(23)25/h2-5,9-10H,6-8H2,1H3,(H,21,24)(H,19,20,22) HJUDFJRTVGXBRF-UHFFFAOYSA-N 351570 N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 14 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351570&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 932 3PTG 46869741 386045987 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695637 Cc1n[nH]c(n1)-c1c(C)csc1NC(=O)CN1C(=O)CCc2ccccc12 InChI=1S/C19H19N5O2S/c1-11-10-27-19(17(11)18-20-12(2)22-23-18)21-15(25)9-24-14-6-4-3-5-13(14)7-8-16(24)26/h3-6,10H,7-9H2,1-2H3,(H,21,25)(H,20,22,23) UNUTTXCETMYXRD-UHFFFAOYSA-N 351571 N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 15 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351571&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869674 386045988 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695640 COc1ccc(CC(=O)Nc2ccsc2-c2nc(n[nH]2)-c2ccncc2)cc1 InChI=1S/C20H17N5O2S/c1-27-15-4-2-13(3-5-15)12-17(26)22-16-8-11-28-18(16)20-23-19(24-25-20)14-6-9-21-10-7-14/h2-11H,12H2,1H3,(H,22,26)(H,23,24,25) SARASZPPYBFQBB-UHFFFAOYSA-N 351572 2-(4-methoxyphenyl)-N-(2-(3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)thiophen-3-yl)acetamide::US9796706, Compound 16 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351572&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869675 386045989 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695642 COc1ccc(CC(=O)Nc2ccsc2-c2nc(N)n[nH]2)cc1 InChI=1S/C15H15N5O2S/c1-22-10-4-2-9(3-5-10)8-12(21)17-11-6-7-23-13(11)14-18-15(16)20-19-14/h2-7H,8H2,1H3,(H,17,21)(H3,16,18,19,20) AFCVEHHRQVGWID-UHFFFAOYSA-N 351573 N-(2-(3-amino-1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 17 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351573&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869742 386045990 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695645 Clc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1ncn[nH]1 InChI=1S/C17H14ClN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22) ZOUZXNPDTXVSEH-UHFFFAOYSA-N 351574 N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 18 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351574&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869673 386045991 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695648 O=C(CN1C(=O)CCc2ccccc12)Nc1sccc1-c1ncn[nH]1 InChI=1S/C17H15N5O2S/c23-14(20-17-12(7-8-25-17)16-18-10-19-21-16)9-22-13-4-2-1-3-11(13)5-6-15(22)24/h1-4,7-8,10H,5-6,9H2,(H,20,23)(H,18,19,21) DQIBFABSPRQMKZ-UHFFFAOYSA-N 351575 N-(3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 19 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351575&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869743 386045992 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695651 Clc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1ncn[nH]1 InChI=1S/C17H12ClN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23) MYLVKAPPYVXQKQ-UHFFFAOYSA-N 351576 N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide::US9796706, Compound 20 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351576&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 45102739 386045993 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695654 Clc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1ncn[nH]1 InChI=1S/C17H12ClN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23) BUCXDWXDBZUFMV-UHFFFAOYSA-N 351577 N-(4-chloro-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 21 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351577&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869816 386045994 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695657 O=C(Cc1ccc2OCCOc2c1)Nc1ccsc1-c1ncn[nH]1 InChI=1S/C16H14N4O3S/c21-14(8-10-1-2-12-13(7-10)23-5-4-22-12)19-11-3-6-24-15(11)16-17-9-18-20-16/h1-3,6-7,9H,4-5,8H2,(H,19,21)(H,17,18,20) SXMNCDMPZQBBJM-UHFFFAOYSA-N 351578 N-(2-(1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide::US9796706, Compound 22 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351578&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869813 386045995 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695660 Cc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1ncn[nH]1 InChI=1S/C18H15N5OS/c1-11-9-25-18(16(11)17-20-10-21-23-17)22-15(24)8-12-4-2-6-14-13(12)5-3-7-19-14/h2-7,9-10H,8H2,1H3,(H,22,24)(H,20,21,23) HQBDXBBDGWHRLC-UHFFFAOYSA-N 351579 N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 23 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351579&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869745 386045996 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695663 Cc1n[nH]c(n1)-c1sccc1NC(=O)Cc1ccc2OCCOc2c1 InChI=1S/C17H16N4O3S/c1-10-18-17(21-20-10)16-12(4-7-25-16)19-15(22)9-11-2-3-13-14(8-11)24-6-5-23-13/h2-4,7-8H,5-6,9H2,1H3,(H,19,22)(H,18,20,21) GWRWRPSYAPTGDG-UHFFFAOYSA-N 351580 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-(2-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)acetamide::US9796706, Compound 24 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351580&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68785137 386045997 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695666 O=C(Cc1cccc2ncccc12)Nc1ccsc1-c1ncn[nH]1 InChI=1S/C17H13N5OS/c23-15(9-11-3-1-5-13-12(11)4-2-7-18-13)21-14-6-8-24-16(14)17-19-10-20-22-17/h1-8,10H,9H2,(H,21,23)(H,19,20,22) MGGUVSLBKUKUGR-UHFFFAOYSA-N 351581 N-(2-(1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 25 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351581&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869877 386045998 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695669 Cc1n[nH]c(n1)-c1c(C)csc1NC(=O)Cc1cccc2ncccc12 InChI=1S/C19H17N5OS/c1-11-10-26-19(17(11)18-21-12(2)23-24-18)22-16(25)9-13-5-3-7-15-14(13)6-4-8-20-15/h3-8,10H,9H2,1-2H3,(H,22,25)(H,21,23,24) YPUXXNJBUOZMOQ-UHFFFAOYSA-N 351582 N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 26 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351582&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869817 386045999 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695672 Cc1csc(NC(=O)Cc2cccc3nccnc23)c1-c1ncn[nH]1 InChI=1S/C17H14N6OS/c1-10-8-25-17(14(10)16-20-9-21-23-16)22-13(24)7-11-3-2-4-12-15(11)19-6-5-18-12/h2-6,8-9H,7H2,1H3,(H,22,24)(H,20,21,23) PUTIJCKMSRBHDZ-UHFFFAOYSA-N 351583 N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinoxalin-5-yl)acetamide::US9796706, Compound 27 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351583&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869744 386046000 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695675 Cc1n[nH]c(n1)-c1c(C)csc1NC(=O)Cc1cccc2nccnc12 InChI=1S/C18H16N6OS/c1-10-9-26-18(15(10)17-21-11(2)23-24-17)22-14(25)8-12-4-3-5-13-16(12)20-7-6-19-13/h3-7,9H,8H2,1-2H3,(H,22,25)(H,21,23,24) UBQAXNUSTYBVJI-UHFFFAOYSA-N 351584 N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinoxalin-5-yl)acetamide::US9796706, Compound 28 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351584&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869815 386046001 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695678 Cc1csc(NC(=O)Cc2ccc(OCCCN3CCCCC3)cc2)c1-c1ncn[nH]1 InChI=1S/C23H29N5O2S/c1-17-15-31-23(21(17)22-24-16-25-27-22)26-20(29)14-18-6-8-19(9-7-18)30-13-5-12-28-10-3-2-4-11-28/h6-9,15-16H,2-5,10-14H2,1H3,(H,26,29)(H,24,25,27) GEPDDGUANAKFCY-UHFFFAOYSA-N 351585 N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)acetamide::US9796706, Compound 29 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351585&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869818 386046002 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695681 Cc1n[nH]c(n1)-c1c(C)csc1NC(=O)Cc1ccc(OCCCN2CCCCC2)cc1 InChI=1S/C24H31N5O2S/c1-17-16-32-24(22(17)23-25-18(2)27-28-23)26-21(30)15-19-7-9-20(10-8-19)31-14-6-13-29-11-4-3-5-12-29/h7-10,16H,3-6,11-15H2,1-2H3,(H,26,30)(H,25,27,28) JXLXJDMNSAFVFP-UHFFFAOYSA-N 351586 N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)acetamide::US9796706, Compound 30 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351586&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869876 386046003 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695684 Cc1csc(NC(=O)Cc2ccc(OCCn3ccnc3)cc2)c1-c1ncn[nH]1 InChI=1S/C20H20N6O2S/c1-14-11-29-20(18(14)19-22-12-23-25-19)24-17(27)10-15-2-4-16(5-3-15)28-9-8-26-7-6-21-13-26/h2-7,11-13H,8-10H2,1H3,(H,24,27)(H,22,23,25) KTMWMJDQJZKADH-UHFFFAOYSA-N 351587 2-(4-(2-(1H-imidazol-1-yl)ethoxy)phenyl)-N-(4-methyl-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)acetamide::US9796706, Compound 31 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351587&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869812 386046004 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695687 Brc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1ncn[nH]1 InChI=1S/C17H12BrN5OS/c18-13-8-25-17(15(13)16-20-9-21-23-16)22-14(24)6-10-2-1-3-11-7-19-5-4-12(10)11/h1-5,7-9H,6H2,(H,22,24)(H,20,21,23) GLVDZCDUMFNCFY-UHFFFAOYSA-N 351588 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide::US9796706, Compound 32 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351588&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869878 386046005 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695690 Brc1csc(NC(=O)Cc2cccc3ncccc23)c1-c1ncn[nH]1 InChI=1S/C17H12BrN5OS/c18-12-8-25-17(15(12)16-20-9-21-23-16)22-14(24)7-10-3-1-5-13-11(10)4-2-6-19-13/h1-6,8-9H,7H2,(H,22,24)(H,20,21,23) IHBXLESUKAAQDQ-UHFFFAOYSA-N 351589 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 33 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351589&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869879 386046006 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695693 Brc1csc(NC(=O)CN2C(=O)CCc3ccccc23)c1-c1ncn[nH]1 InChI=1S/C17H14BrN5O2S/c18-11-8-26-17(15(11)16-19-9-20-22-16)21-13(24)7-23-12-4-2-1-3-10(12)5-6-14(23)25/h1-4,8-9H,5-7H2,(H,21,24)(H,19,20,22) JCKBTQZTGPJTII-UHFFFAOYSA-N 351590 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 34 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351590&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869882 386046007 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695696 O=C(Cc1cccc2cnccc12)Nc1scc(C#N)c1-c1ncn[nH]1 InChI=1S/C18H12N6OS/c19-7-13-9-26-18(16(13)17-21-10-22-24-17)23-15(25)6-11-2-1-3-12-8-20-5-4-14(11)12/h1-5,8-10H,6H2,(H,23,25)(H,21,22,24) VINQLWACVZJJIO-UHFFFAOYSA-N 351591 N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(isoquinolin-5-yl)acetamide::US9796706, Compound 35 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351591&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868853 386046008 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695699 O=C(CN1C(=O)CCc2ccccc12)Nc1scc(C#N)c1-c1ncn[nH]1 InChI=1S/C18H14N6O2S/c19-7-12-9-27-18(16(12)17-20-10-21-23-17)22-14(25)8-24-13-4-2-1-3-11(13)5-6-15(24)26/h1-4,9-10H,5-6,8H2,(H,22,25)(H,20,21,23) WNRCGOJLZOLSJN-UHFFFAOYSA-N 351592 N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 36 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351592&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 34I 3RTP 46869880 386046009 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695702 Cc1n[nH]c(n1)-c1sccc1NC(=O)Cc1ccc(cc1)N1CCCC1=O InChI=1S/C19H19N5O2S/c1-12-20-19(23-22-12)18-15(8-10-27-18)21-16(25)11-13-4-6-14(7-5-13)24-9-2-3-17(24)26/h4-8,10H,2-3,9,11H2,1H3,(H,21,25)(H,20,22,23) UBVNZSDKAQLHEH-UHFFFAOYSA-N 351593 N-(2-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-3-yl)-2-(4-(2-oxopyrrolidin-1-yl)phenyl)acetamide::US9796706, Compound 37 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351593&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868854 386046010 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695705 Cc1nnc([nH]1)-c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1 InChI=1S/C21H19N5OS/c1-13-12-28-21(19(13)20-23-14(2)25-26-20)24-18(27)11-15-3-5-16(6-4-15)17-7-9-22-10-8-17/h3-10,12H,11H2,1-2H3,(H,24,27)(H,23,25,26) LRMJMUNRVWCGNU-UHFFFAOYSA-N 50338284 CHEMBL1682007::N-(4-methyl-3-(3-methyl-1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(4-(pyridin-4-yl)phenyl)acetamide::US9796706, Compound 38 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338284&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868855 125088386 CHEMBL1682007 ZINC66079863 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695708 O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1nnc[nH]1 InChI=1S/C18H12N6OS/c19-8-12-9-26-18(16(12)17-21-10-22-24-17)23-15(25)7-11-3-1-5-14-13(11)4-2-6-20-14/h1-6,9-10H,7H2,(H,23,25)(H,21,22,24) XCGZBGKVXSQTFT-UHFFFAOYSA-N 50338267 CHEMBL1682021::N-(4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 39 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50338267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50338267&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868856 125088369 CHEMBL1682021 ZINC66078020 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695711 FC(F)(F)c1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1 InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-5-10(18(20,21)22)3-1-9(12)2-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) UBEKWKCSOKGROP-UHFFFAOYSA-N 351596 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-7-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 107::US9796706, Compound 40 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351596&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869881 386046012 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695714 Fc1ccc2N(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)C(=O)CCc2c1 InChI=1S/C17H13BrFN5O2S/c18-11-7-27-17(15(11)16-20-8-21-23-16)22-13(25)6-24-12-3-2-10(19)5-9(12)1-4-14(24)26/h2-3,5,7-8H,1,4,6H2,(H,22,25)(H,20,21,23) AHZNJVVIJQWSOW-UHFFFAOYSA-N 351597 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-fluoro-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 41 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351597&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868858 386046013 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695717 Fc1ccc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1 InChI=1S/C17H11BrFN5O2S/c18-11-7-27-17(15(11)16-20-8-21-23-16)22-13(25)6-24-12-5-10(19)3-1-9(12)2-4-14(24)26/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23) TWVRHWLWIMQYFE-UHFFFAOYSA-N 351598 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(7-fluoro-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 42 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351598&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868857 386046014 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695720 Clc1ccc2CCC(=O)N(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2c1 InChI=1S/C17H13BrClN5O2S/c18-11-7-27-17(15(11)16-20-8-21-23-16)22-13(25)6-24-12-5-10(19)3-1-9(12)2-4-14(24)26/h1,3,5,7-8H,2,4,6H2,(H,22,25)(H,20,21,23) ZZRZIFUHBRATSO-UHFFFAOYSA-N 351599 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(7-chloro-2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide::US9796706, Compound 43 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351599&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868859 386046015 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695723 Fc1cc2ccc(=O)n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c2cc1F InChI=1S/C17H10BrF2N5O2S/c18-9-6-28-17(15(9)16-21-7-22-24-16)23-13(26)5-25-12-4-11(20)10(19)3-8(12)1-2-14(25)27/h1-4,6-7H,5H2,(H,23,26)(H,21,22,24) TXUPRVNNKMSBLZ-UHFFFAOYSA-N 351600 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6,7-difluoro-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 44 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351600&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868925 386046016 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695726 FC(F)(F)c1ccc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2c1 InChI=1S/C18H11BrF3N5O2S/c19-11-7-30-17(15(11)16-23-8-24-26-16)25-13(28)6-27-12-3-2-10(18(20,21)22)5-9(12)1-4-14(27)29/h1-5,7-8H,6H2,(H,25,28)(H,23,24,26) CRWXJGJNJZPMRW-UHFFFAOYSA-N 351601 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(2-oxo-6-(trifluoromethyl)quinolin-1(2H)-yl)acetamide::US9796706, Compound 45::US9796706, Compound 91 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351601&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868926 386046017 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695729 Fc1ccc2n(CC(=O)Nc3scc(Br)c3-c3ncn[nH]3)c(=O)ccc2c1 InChI=1S/C17H11BrFN5O2S/c18-11-7-27-17(15(11)16-20-8-21-23-16)22-13(25)6-24-12-3-2-10(19)5-9(12)1-4-14(24)26/h1-5,7-8H,6H2,(H,22,25)(H,20,21,23) CLOIVWNJBIOAKH-UHFFFAOYSA-N 351602 N-(4-bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(6-fluoro-2-oxoquinolin-1(2H)-yl)acetamide::US9796706, Compound 46 Mitogen-activated protein kinase 10 Homo sapiens <100 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351602&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868927 386046018 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695732 Cc1csc(n1)-c1sccc1NC(=O)Cc1cccc2cnccc12 InChI=1S/C19H15N3OS2/c1-12-11-25-19(21-12)18-16(6-8-24-18)22-17(23)9-13-3-2-4-14-10-20-7-5-15(13)14/h2-8,10-11H,9H2,1H3,(H,22,23) MGDUDCNKFCTDIM-UHFFFAOYSA-N 351603 2-(isoquinolin-5-yl)-N-(2-(4-methylthiazol-2-yl)thiophen-3-yl)acetamide::US9796706, Compound 47 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351603&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868928 386046019 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695735 O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1cscn1 InChI=1S/C18H13N3OS2/c22-17(8-12-2-1-3-13-9-19-6-4-14(12)13)21-15-5-7-24-18(15)16-10-23-11-20-16/h1-7,9-11H,8H2,(H,21,22) FFPJBQIHDBPVHZ-UHFFFAOYSA-N 50332086 2-(isoquinolin-5-yl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide::CHEMBL1288100::US9796706, Compound 48 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332086&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868930 123111201 CHEMBL1288100 ZINC64560850 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695738 O=C(CN1C(=O)CCc2cnccc12)Nc1ccsc1-c1cscn1 InChI=1S/C17H14N4O2S2/c22-15(20-12-4-6-25-17(12)13-9-24-10-19-13)8-21-14-3-5-18-7-11(14)1-2-16(21)23/h3-7,9-10H,1-2,8H2,(H,20,22) JSHODZWURBJNCA-UHFFFAOYSA-N 351605 2-(2-oxo-3,4-dihydro-1,6-naphthyridin-1(2H)-yl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide::US9796706, Compound 49 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351605&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868996 386046021 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695741 O=C(CN1C(=O)CCc2ccccc12)Nc1ccsc1-c1cscn1 InChI=1S/C18H15N3O2S2/c22-16(20-13-7-8-25-18(13)14-10-24-11-19-14)9-21-15-4-2-1-3-12(15)5-6-17(21)23/h1-4,7-8,10-11H,5-6,9H2,(H,20,22) JQGZHLGVJFPXBA-UHFFFAOYSA-N 351606 2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide::US9796706, Compound 50 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351606&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868995 386046022 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695744 COc1nc(cs1)-c1sccc1NC(=O)Cc1cccc2cnccc12 InChI=1S/C19H15N3O2S2/c1-24-19-22-16(11-26-19)18-15(6-8-25-18)21-17(23)9-12-3-2-4-13-10-20-7-5-14(12)13/h2-8,10-11H,9H2,1H3,(H,21,23) SGLAWNRVCPGBGO-UHFFFAOYSA-N 351607 2-(isoquinolin-5-yl)-N-(2-(2-methoxythiazol-4-yl)thiophen-3-yl)acetamide::US9796706, Compound 51 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351607&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868994 386046023 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695747 Clc1nc(cs1)-c1sccc1NC(=O)Cc1cccc2cnccc12 InChI=1S/C18H12ClN3OS2/c19-18-22-15(10-25-18)17-14(5-7-24-17)21-16(23)8-11-2-1-3-12-9-20-6-4-13(11)12/h1-7,9-10H,8H2,(H,21,23) QJRBMEGWWYLDAY-UHFFFAOYSA-N 351608 N-(2-(2-chlorothiazol-4-yl)thiophen-3-yl)-2-(isoquinolin-5-yl)acetamide::US9796706, Compound 52 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351608&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869070 386046024 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695750 O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1nccs1 InChI=1S/C18H13N3OS2/c22-16(10-12-2-1-3-13-11-19-6-4-14(12)13)21-15-5-8-23-17(15)18-20-7-9-24-18/h1-9,11H,10H2,(H,21,22) HBQYSSWFSRNTKL-UHFFFAOYSA-N 351609 2-(isoquinolin-5-yl)-N-(2-(thiazol-2-yl)thiophen-3-yl)acetamide::US9796706, Compound 53 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351609&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868998 386046025 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695753 Cc1cnc(s1)-c1sccc1NC(=O)Cc1cccc2cnccc12 InChI=1S/C19H15N3OS2/c1-12-10-21-19(25-12)18-16(6-8-24-18)22-17(23)9-13-3-2-4-14-11-20-7-5-15(13)14/h2-8,10-11H,9H2,1H3,(H,22,23) PZKZHKAQWVQUPJ-UHFFFAOYSA-N 351610 2-(isoquinolin-5-yl)-N-(2-(5-methylthiazol-2-yl)thiophen-3-yl)acetamide::US9796706, Compound 54 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351610&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868997 386046026 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695756 O=C(Cc1ccc(OCCCN2CCCCC2)cc1)Nc1ccsc1-c1cscn1 InChI=1S/C23H27N3O2S2/c27-22(25-20-9-14-30-23(20)21-16-29-17-24-21)15-18-5-7-19(8-6-18)28-13-4-12-26-10-2-1-3-11-26/h5-9,14,16-17H,1-4,10-13,15H2,(H,25,27) MPRMTGSCCYUXJR-UHFFFAOYSA-N 351611 2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-N-(2-(thiazol-4-yl)thiophen-3-yl)acetamide::US9796706, Compound 55 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351611&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868999 386046027 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695759 Cc1csc(NC(=O)Cc2cccc3cnccc23)c1-c1nc2ccccc2s1 InChI=1S/C23H17N3OS2/c1-14-13-28-22(21(14)23-25-18-7-2-3-8-19(18)29-23)26-20(27)11-15-5-4-6-16-12-24-10-9-17(15)16/h2-10,12-13H,11H2,1H3,(H,26,27) RIWOUTFIUQAVSK-UHFFFAOYSA-N 351612 N-(3-(benzo[d]thiazol-2-yl)-4-methylthiophen-2-yl)-2-(isoquinolin-5-yl)acetamide::US9796706, Compound 56 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351612&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68786952 386046028 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695762 COc1ccc(CC(=O)Nc2ccsc2-c2ncco2)cc1 InChI=1S/C16H14N2O3S/c1-20-12-4-2-11(3-5-12)10-14(19)18-13-6-9-22-15(13)16-17-7-8-21-16/h2-9H,10H2,1H3,(H,18,19) KSZHRLGDJPCAID-UHFFFAOYSA-N 50332082 2-(4-methoxyphenyl)-N-(2-(oxazol-2-yl)thiophen-3-yl)acetamide::CHEMBL1288068::US9796706, Compound 57 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332082&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869000 123111197 CHEMBL1288068 ZINC64559318 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695765 O=C(Cc1cccc2cnccc12)Nc1ccsc1-c1ncco1 InChI=1S/C18H13N3O2S/c22-16(10-12-2-1-3-13-11-19-6-4-14(12)13)21-15-5-9-24-17(15)18-20-7-8-23-18/h1-9,11H,10H2,(H,21,22) LXBGKEBHKHJTIX-UHFFFAOYSA-N 351614 2-(isoquinolin-5-yl)-N-(2-(oxazol-2-yl)thiophen-3-yl)acetamide::US9796706, Compound 58 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351614&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868931 386046030 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695768 COc1ccc(CC(=O)Nc2sccc2-c2noc(C)n2)cc1 InChI=1S/C16H15N3O3S/c1-10-17-15(19-22-10)13-7-8-23-16(13)18-14(20)9-11-3-5-12(21-2)6-4-11/h3-8H,9H2,1-2H3,(H,18,20) JWKYWPAXWSIVQX-UHFFFAOYSA-N 351615 2-(4-methoxyphenyl)-N-(3-(5-methyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl)acetamide::US9796706, Compound 59 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351615&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46868929 386046031 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695771 O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1nnco1 InChI=1S/C18H13N3O2S/c22-16(10-13-6-3-5-12-4-1-2-7-14(12)13)20-15-8-9-24-17(15)18-21-19-11-23-18/h1-9,11H,10H2,(H,20,22) ROLXVDFEIIZXAF-UHFFFAOYSA-N 50332067 CHEMBL1287888::N-(2-(1,3,4-oxadiazol-2-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 60 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332067&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869071 123111182 CHEMBL1287888 ZINC64559180 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695774 COc1ccc(CC(=O)Nc2ccsc2-c2nnc(C)o2)cc1 InChI=1S/C16H15N3O3S/c1-10-18-19-16(22-10)15-13(7-8-23-15)17-14(20)9-11-3-5-12(21-2)6-4-11/h3-8H,9H2,1-2H3,(H,17,20) WSHCUBFDEUTKHF-UHFFFAOYSA-N 351617 2-(4-methoxyphenyl)-N-(2-(5-methyl-1,3,4-oxadiazol-2-yl)thiophen-3-yl)acetamide::US9796706, Compound 61 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351617&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869072 386046033 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695776 COc1ccc(CC(=O)Nc2ccsc2-c2nnc(o2)C(C)C)cc1 InChI=1S/C18H19N3O3S/c1-11(2)17-20-21-18(24-17)16-14(8-9-25-16)19-15(22)10-12-4-6-13(23-3)7-5-12/h4-9,11H,10H2,1-3H3,(H,19,22) SPUMGFRXJHGEFF-UHFFFAOYSA-N 351618 N-(2-(5-isopropyl-1,3,4-oxadiazol-2-yl)thiophen-3-yl)-2-(4-methoxyphenyl)acetamide::US9796706, Compound 62 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351618&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869073 386046034 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695778 Cc1nnc(o1)-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C19H15N3O2S/c1-12-21-22-19(24-12)18-16(9-10-25-18)20-17(23)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,20,23) BKDRDDSAZLVHON-UHFFFAOYSA-N 50332071 CHEMBL1287944::N-(2-(5-methyl-1,3,4-oxadiazol-2-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 63 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332071&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52944873 123111186 CHEMBL1287944 ZINC64549834 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695781 Cc1noc(n1)-c1c(C)csc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C20H17N3O2S/c1-12-11-26-20(18(12)19-21-13(2)23-25-19)22-17(24)10-15-8-5-7-14-6-3-4-9-16(14)15/h3-9,11H,10H2,1-2H3,(H,22,24) LIZNJENLIKQOAW-UHFFFAOYSA-N 351620 N-(4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)thiophen-2-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 64 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351620&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869076 386046036 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695784 Cc1noc(n1)-c1c(C)csc1NC(=O)Cc1ccc(cc1)-c1ccncc1 InChI=1S/C21H18N4O2S/c1-13-12-28-21(19(13)20-23-14(2)25-27-20)24-18(26)11-15-3-5-16(6-4-15)17-7-9-22-10-8-17/h3-10,12H,11H2,1-2H3,(H,24,26) KAKWVQRFLWKQRX-UHFFFAOYSA-N 351621 N-(4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)thiophen-2-yl)-2-(4-(pyridin-4-yl)phenyl)acetamide::US9796706, Compound 65 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351621&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869146 386046037 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695787 Cc1noc(n1)-c1sccc1NC(=O)Cc1cccc2ccccc12 InChI=1S/C19H15N3O2S/c1-12-20-19(24-22-12)18-16(9-10-25-18)21-17(23)11-14-7-4-6-13-5-2-3-8-15(13)14/h2-10H,11H2,1H3,(H,21,23) OICBMTSZGYFITJ-UHFFFAOYSA-N 351622 N-(2-(3-methyl-1,2,4-oxadiazol-5-yl)thiophen-3-yl)-2-(naphthalen-1-yl)acetamide::US9796706, Compound 66 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351622&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869074 386046038 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695789 O=C(Cc1cccc2cnccc12)Nc1scnc1-c1ncn[nH]1 InChI=1S/C16H12N6OS/c23-13(6-10-2-1-3-11-7-17-5-4-12(10)11)21-16-14(19-9-24-16)15-18-8-20-22-15/h1-5,7-9H,6H2,(H,21,23)(H,18,20,22) CCEORUFGHAKXQE-UHFFFAOYSA-N 351623 N-(4-(1H-1,2,4-triazol-5-yl)thiazol-5-yl)-2-(isoquinolin-5-yl)acetamide::US9796706, Compound 67 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351623&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869149 386046039 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695792 Cn1ncnc1-c1ncsc1NC(=O)Cc1cccc2cnccc12 InChI=1S/C17H14N6OS/c1-23-16(19-9-21-23)15-17(25-10-20-15)22-14(24)7-11-3-2-4-12-8-18-6-5-13(11)12/h2-6,8-10H,7H2,1H3,(H,22,24) UIDLYPCNTOHNOP-UHFFFAOYSA-N 50332089 2-(isoquinolin-5-yl)-N-(4-(1-methyl-1H-1,2,4-triazol-5-yl)thiazol-5-yl)acetamide::CHEMBL1288129::US9796706, Compound 68 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332089&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 52942507 123111204 CHEMBL1288129 ZINC64560478 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695795 O=C(Cc1cccc2ccccc12)Nc1ccsc1-c1ccccn1 InChI=1S/C21H16N2OS/c24-20(14-16-8-5-7-15-6-1-2-9-17(15)16)23-19-11-13-25-21(19)18-10-3-4-12-22-18/h1-13H,14H2,(H,23,24) YSAASBOGVGHEFN-UHFFFAOYSA-N 351625 2-(2-pyridyl)-3-(1-naphthylacetylamino)thiophene::US9796706, Compound 69 Mitogen-activated protein kinase 10 Homo sapiens 5050 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351625&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 68754665 386046041 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695796 COc1ccc(CC(=O)Nc2ccsc2-n2cccn2)cc1 InChI=1S/C16H15N3O2S/c1-21-13-5-3-12(4-6-13)11-15(20)18-14-7-10-22-16(14)19-9-2-8-17-19/h2-10H,11H2,1H3,(H,18,20) FOTNQVRTTZINQO-UHFFFAOYSA-N 351626 N-(2-(1H-pyrazol-1-yl)thiophen-3-yl)-2-(4-methoxyphenyl)-acetamide::US9796706, Compound 70 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869150 386046042 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 695798 COc1ccc(CC(=O)Nc2ccsc2-n2cc(C)cn2)cc1 InChI=1S/C17H17N3O2S/c1-12-10-18-20(11-12)17-15(7-8-23-17)19-16(21)9-13-3-5-14(22-2)6-4-13/h3-8,10-11H,9H2,1-2H3,(H,19,21) UEXZHPNBIYUBAX-UHFFFAOYSA-N 351627 2-(4-methoxyphenyl)-N-(2-(4-methyl-1H-pyrazol-1-yl)thiophen-3-yl)acetamide::US9796706, Compound 71 Mitogen-activated protein kinase 10 Homo sapiens >10000 US Patent 10.7270/Q24T6MHK aid1797500 US9796706 Sham, HL; Hom, RK; Konradi, AW; Probst, GD; Bowers, S; Truong, A; Neitz, RJ; Sealy, J; Toth, G Imago Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=351627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=351627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 46869151 386046043 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50766612 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1 InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ GJFCSAPFHAXMSF-UXBLZVDNSA-N 86633 JNK-IN-8 Mitogen-activated protein kinase 10 Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.6b00788 10.7270/Q2JW8H9T 27996267 Jackson, PA; Widen, JC; Harki, DA; Brummond, KM University of Pittsburgh http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340686 136352682 ZINC89464842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784798 N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C21H20N6O3/c22-7-3-16-12-24-20(14-1-2-17-18(11-14)30-13-29-17)27(16)19-4-8-23-21(26-19)25-15-5-9-28-10-6-15/h1-2,4,8,11-12,15H,3,5-6,9-10,13H2,(H,23,25,26) SVUITGIIKADDAF-UHFFFAOYSA-N 392707 Example 1::US10301291, Compound 10a Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392707&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389175 404961032 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784799 N#CCc1cnc(-c2ccc3OCCOc3c2)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C22H22N6O3/c23-7-3-17-14-25-21(15-1-2-18-19(13-15)31-12-11-30-18)28(17)20-4-8-24-22(27-20)26-16-5-9-29-10-6-16/h1-2,4,8,13-14,16H,3,5-6,9-12H2,(H,24,26,27) DXAYFEKMSRSNLO-UHFFFAOYSA-N 392708 Example 2::US10301291, Compound 10b Mitogen-activated protein kinase 10 Homo sapiens >100 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392708&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389049 404961033 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784800 N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C23H21N7O/c24-11-7-18-15-26-22(20-6-5-16-3-1-2-4-19(16)28-20)30(18)21-8-12-25-23(29-21)27-17-9-13-31-14-10-17/h1-6,8,12,15,17H,7,9-10,13-14H2,(H,25,27,29) GHWROBLEMLUTAG-UHFFFAOYSA-N 392709 Example 3::US10301291, Compound 10c Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392709&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389196 404961034 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784801 N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C24H22N6O/c25-11-7-21-16-27-23(19-6-5-17-3-1-2-4-18(17)15-19)30(21)22-8-12-26-24(29-22)28-20-9-13-31-14-10-20/h1-6,8,12,15-16,20H,7,9-10,13-14H2,(H,26,28,29) QUHKJAZRLNYDCD-UHFFFAOYSA-N 392710 Example 4::US10301291, Compound 10d Mitogen-activated protein kinase 10 Homo sapiens <30 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392710&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389001 404961035 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784802 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C20H18Cl2N6O/c21-16-2-1-13(11-17(16)22)19-25-12-15(3-7-23)28(19)18-4-8-24-20(27-18)26-14-5-9-29-10-6-14/h1-2,4,8,11-12,14H,3,5-6,9-10H2,(H,24,26,27) JLBWDBPHKABVBE-UHFFFAOYSA-N 392711 Example 5::US10301291, Compound 10e Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392711&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389309 404961036 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784803 Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C21H18F4N6O/c22-17-2-1-13(11-16(17)21(23,24)25)19-28-12-15(3-7-26)31(19)18-4-8-27-20(30-18)29-14-5-9-32-10-6-14/h1-2,4,8,11-12,14H,3,5-6,9-10H2,(H,27,29,30) QUAMEPWGALLEMV-UHFFFAOYSA-N 392712 Example 6::US10301291, Compound 10f Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392712&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389219 404961037 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784804 N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C22H22N6O2/c23-10-8-17-13-25-21(15-6-7-18-19(12-15)30-14-29-18)28(17)20-9-11-24-22(27-20)26-16-4-2-1-3-5-16/h6-7,9,11-13,16H,1-5,8,14H2,(H,24,26,27) OFUMROLKEGKJMS-UHFFFAOYSA-N 392713 Example 7::US10301291, Compound 11a Mitogen-activated protein kinase 10 Homo sapiens >100 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392713&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389052 404961038 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784805 N#CCc1cnc(-c2ccc3OCCOc3c2)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C23H24N6O2/c24-10-8-18-15-26-22(16-6-7-19-20(14-16)31-13-12-30-19)29(18)21-9-11-25-23(28-21)27-17-4-2-1-3-5-17/h6-7,9,11,14-15,17H,1-5,8,12-13H2,(H,25,27,28) ORHHPSNLVCWQPB-UHFFFAOYSA-N 392714 Example 8::US10301291, Compound 11b Mitogen-activated protein kinase 10 Homo sapiens >100 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392714&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389311 404961039 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784806 N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C24H23N7/c25-14-12-19-16-27-23(21-11-10-17-6-4-5-9-20(17)29-21)31(19)22-13-15-26-24(30-22)28-18-7-2-1-3-8-18/h4-6,9-11,13,15-16,18H,1-3,7-8,12H2,(H,26,28,30) YAYHNPYFBMMMLU-UHFFFAOYSA-N 392715 Example 9::US10301291, Compound 11c Mitogen-activated protein kinase 10 Homo sapiens >100 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392715&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 130296606 404961040 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784807 N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C25H24N6/c26-14-12-22-17-28-24(20-11-10-18-6-4-5-7-19(18)16-20)31(22)23-13-15-27-25(30-23)29-21-8-2-1-3-9-21/h4-7,10-11,13,15-17,21H,1-3,8-9,12H2,(H,27,29,30) GJLZMTDDJPNXPU-UHFFFAOYSA-N 392716 Example 10::US10301291, Compound 11d Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392716&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389213 404961041 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784808 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C21H20Cl2N6/c22-17-7-6-14(12-18(17)23)20-26-13-16(8-10-24)29(20)19-9-11-25-21(28-19)27-15-4-2-1-3-5-15/h6-7,9,11-13,15H,1-5,8H2,(H,25,27,28) LGWZSUMBRCSBJL-UHFFFAOYSA-N 392717 Example 11::US10301291, Compound 11e Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392717&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137452985 404961042 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784809 Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C22H20F4N6/c23-18-7-6-14(12-17(18)22(24,25)26)20-29-13-16(8-10-27)32(20)19-9-11-28-21(31-19)30-15-4-2-1-3-5-15/h6-7,9,11-13,15H,1-5,8H2,(H,28,30,31) IIPOJSVNSFFFPM-UHFFFAOYSA-N 392718 Example 12::US10301291, Compound 11f Mitogen-activated protein kinase 10 Homo sapiens >100 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392718&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389080 404961043 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784810 CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCOc2c1 InChI=1S/C19H18N6O3/c1-12(26)9-23-19-21-7-5-17(24-19)25-14(4-6-20)10-22-18(25)13-2-3-15-16(8-13)28-11-27-15/h2-3,5,7-8,10,12,26H,4,9,11H2,1H3,(H,21,23,24) KBMVXTJPDJPUCK-UHFFFAOYSA-N 392719 Example 13::US10301291, Compound 12a Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392719&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389162 404961044 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784811 CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCCOc2c1 InChI=1S/C20H20N6O3/c1-13(27)11-24-20-22-7-5-18(25-20)26-15(4-6-21)12-23-19(26)14-2-3-16-17(10-14)29-9-8-28-16/h2-3,5,7,10,12-13,27H,4,8-9,11H2,1H3,(H,22,24,25) BAHBVVGCFLNSRU-UHFFFAOYSA-N 392720 Example 14::US10301291, Compound 12b Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392720&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389056 404961045 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784812 CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2n1 InChI=1S/C21H19N7O/c1-14(29)12-25-21-23-11-9-19(27-21)28-16(8-10-22)13-24-20(28)18-7-6-15-4-2-3-5-17(15)26-18/h2-7,9,11,13-14,29H,8,12H2,1H3,(H,23,25,27) MTLGSBMSYAUVFE-UHFFFAOYSA-N 392721 Example 15::US10301291, Compound 12c Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392721&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 130296784 404961046 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784813 CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1 InChI=1S/C22H20N6O/c1-15(29)13-26-22-24-11-9-20(27-22)28-19(8-10-23)14-25-21(28)18-7-6-16-4-2-3-5-17(16)12-18/h2-7,9,11-12,14-15,29H,8,13H2,1H3,(H,24,26,27) DILISPNYIVRDBP-UHFFFAOYSA-N 392722 Example 16::US10301291, Compound 12d Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392722&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 130296741 404961047 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784814 CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc(Cl)c(Cl)c1 InChI=1S/C18H16Cl2N6O/c1-11(27)9-24-18-22-7-5-16(25-18)26-13(4-6-21)10-23-17(26)12-2-3-14(19)15(20)8-12/h2-3,5,7-8,10-11,27H,4,9H2,1H3,(H,22,24,25) SSORSZACHCNXSJ-UHFFFAOYSA-N 392723 Example 17::US10301291, Compound 12e Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392723&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389305 404961048 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784815 CC(O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc(F)c(c1)C(F)(F)F InChI=1S/C19H16F4N6O/c1-11(30)9-27-18-25-7-5-16(28-18)29-13(4-6-24)10-26-17(29)12-2-3-15(20)14(8-12)19(21,22)23/h2-3,5,7-8,10-11,30H,4,9H2,1H3,(H,25,27,28) GXHNDVQIVCWVNB-UHFFFAOYSA-N 392724 Example 18::US10301291, Compound 12f Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392724&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389157 404961049 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784816 N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCCNC2)n1 InChI=1S/C21H21N7O2/c22-7-5-16-12-25-20(14-3-4-17-18(10-14)30-13-29-17)28(16)19-6-9-24-21(27-19)26-15-2-1-8-23-11-15/h3-4,6,9-10,12,15,23H,1-2,5,8,11,13H2,(H,24,26,27) WQGFIOYKMIQZHY-UHFFFAOYSA-N 392725 Example 25::US10301291, Compound 14a Mitogen-activated protein kinase 10 Homo sapiens >100 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392725&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389381 404961050 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784817 N#CCc1cnc(-c2ccc3OCCOc3c2)n1-c1ccnc(NC2CCCNC2)n1 InChI=1S/C22H23N7O2/c23-7-5-17-14-26-21(15-3-4-18-19(12-15)31-11-10-30-18)29(17)20-6-9-25-22(28-20)27-16-2-1-8-24-13-16/h3-4,6,9,12,14,16,24H,1-2,5,8,10-11,13H2,(H,25,27,28) KIAJIEKKEKCEIV-UHFFFAOYSA-N 392726 Example 26::US10301291, Compound 14b Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392726&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389046 404961051 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784818 N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCCNC2)n1 InChI=1S/C23H22N8/c24-11-9-18-15-27-22(20-8-7-16-4-1-2-6-19(16)29-20)31(18)21-10-13-26-23(30-21)28-17-5-3-12-25-14-17/h1-2,4,6-8,10,13,15,17,25H,3,5,9,12,14H2,(H,26,28,30) MANNUZLBILGUDA-UHFFFAOYSA-N 392727 Example 27::US10301291, Compound 14c Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392727&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389208 404961052 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784819 N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCCNC2)n1 InChI=1S/C24H23N7/c25-11-9-21-16-28-23(19-8-7-17-4-1-2-5-18(17)14-19)31(21)22-10-13-27-24(30-22)29-20-6-3-12-26-15-20/h1-2,4-5,7-8,10,13-14,16,20,26H,3,6,9,12,15H2,(H,27,29,30) PVAQJGAOCRZJQX-UHFFFAOYSA-N 392728 Example 28::US10301291, Compound 14d Mitogen-activated protein kinase 10 Homo sapiens <30 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392728&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389383 404961053 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784820 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCCNC2)n1 InChI=1S/C20H19Cl2N7/c21-16-4-3-13(10-17(16)22)19-26-12-15(5-7-23)29(19)18-6-9-25-20(28-18)27-14-2-1-8-24-11-14/h3-4,6,9-10,12,14,24H,1-2,5,8,11H2,(H,25,27,28) KDDPNNXAZURUGP-UHFFFAOYSA-N 392729 Example 29::US10301291, Compound 14e Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392729&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389168 404961054 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784821 Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCCNC2)n1 InChI=1S/C21H19F4N7/c22-17-4-3-13(10-16(17)21(23,24)25)19-29-12-15(5-7-26)32(19)18-6-9-28-20(31-18)30-14-2-1-8-27-11-14/h3-4,6,9-10,12,14,27H,1-2,5,8,11H2,(H,28,30,31) BWSQKOKULIALEW-UHFFFAOYSA-N 392730 Example 30::US10301291, Compound 14f Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392730&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389329 404961055 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784822 O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCOc2c1 InChI=1S/C25H25N7O3/c26-9-7-19-13-28-23(17-5-6-20-21(12-17)35-15-34-20)32(19)22-8-10-27-25(30-22)29-18-2-1-11-31(14-18)24(33)16-3-4-16/h5-6,8,10,12-13,16,18H,1-4,7,11,14-15H2,(H,27,29,30) YKYZPYDLFBNATE-UHFFFAOYSA-N 392731 Example 31::US10301291, Compound 15a Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392731&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389164 404961056 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784823 O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCCOc2c1 InChI=1S/C26H27N7O3/c27-9-7-20-15-29-24(18-5-6-21-22(14-18)36-13-12-35-21)33(20)23-8-10-28-26(31-23)30-19-2-1-11-32(16-19)25(34)17-3-4-17/h5-6,8,10,14-15,17,19H,1-4,7,11-13,16H2,(H,28,30,31) AJBMKZZMPSOPRY-UHFFFAOYSA-N 392732 Example 32::US10301291, Compound 15b Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392732&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389051 404961057 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784824 O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2n1 InChI=1S/C27H26N8O/c28-13-11-21-16-30-25(23-10-9-18-4-1-2-6-22(18)32-23)35(21)24-12-14-29-27(33-24)31-20-5-3-15-34(17-20)26(36)19-7-8-19/h1-2,4,6,9-10,12,14,16,19-20H,3,5,7-8,11,15,17H2,(H,29,31,33) TXIPVVLKTCCGPA-UHFFFAOYSA-N 392733 Example 33::US10301291, Compound 15c Mitogen-activated protein kinase 10 Homo sapiens <30 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392733&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389155 404961058 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784825 O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1 InChI=1S/C28H27N7O/c29-13-11-24-17-31-26(22-10-7-19-4-1-2-5-21(19)16-22)35(24)25-12-14-30-28(33-25)32-23-6-3-15-34(18-23)27(36)20-8-9-20/h1-2,4-5,7,10,12,14,16-17,20,23H,3,6,8-9,11,15,18H2,(H,30,32,33) MIFPZJRPCSILQA-UHFFFAOYSA-N 392734 Example 34::US10301291, Compound 15d Mitogen-activated protein kinase 10 Homo sapiens <30 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392734&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389178 404961059 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784826 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C24H23Cl2N7O/c25-19-6-5-16(12-20(19)26)22-29-13-18(7-9-27)33(22)21-8-10-28-24(31-21)30-17-2-1-11-32(14-17)23(34)15-3-4-15/h5-6,8,10,12-13,15,17H,1-4,7,11,14H2,(H,28,30,31) YHJXRSXZOCDBEA-UHFFFAOYSA-N 392735 Example 35::US10301291, Compound 15e Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392735&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389053 404961060 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784827 Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C25H23F4N7O/c26-20-6-5-16(12-19(20)25(27,28)29)22-32-13-18(7-9-30)36(22)21-8-10-31-24(34-21)33-17-2-1-11-35(14-17)23(37)15-3-4-15/h5-6,8,10,12-13,15,17H,1-4,7,11,14H2,(H,31,33,34) AMJPALGZWXBOKQ-UHFFFAOYSA-N 392736 Example 36::US10301291, Compound 15f Mitogen-activated protein kinase 10 Homo sapiens 65 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392736&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389214 404961061 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 784828 O=C(C1CC1)N1CCCC(C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2occc2c1 InChI=1S/C26H25N7O2/c27-10-7-21-15-29-24(19-5-6-22-18(14-19)9-13-35-22)33(21)23-8-11-28-26(31-23)30-20-2-1-12-32(16-20)25(34)17-3-4-17/h5-6,8-9,11,13-15,17,20H,1-4,7,12,16H2,(H,28,30,31) ZBEPMOZEXLGCTF-UHFFFAOYSA-N 392737 Example 37::US10301291, Compound 15g Mitogen-activated protein kinase 10 Homo sapiens <30 US Patent 10.7270/Q20K2BW1 aid1798906 US10301291 Hah, J; Yang, SI; Lee, JH SAMJIN PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392737&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 138668002 404961062 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50910116 CC(C)n1nc(cc1[C@@H]1[C@H]2CN(C[C@@H]12)C1COC1)-c1cnc(N)c(OC(F)(F)F)c1 InChI=1S/C20H24F3N5O2/c1-10(2)28-16(18-13-6-27(7-14(13)18)12-8-29-9-12)4-15(26-28)11-3-17(19(24)25-5-11)30-20(21,22)23/h3-5,10,12-14,18H,6-9H2,1-2H3,(H2,24,25)/t13-,14+,18+ UHEFRVBGJORHNV-UOIKSKOESA-N 50271207 CHEMBL3719135 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.7b00843 10.7270/Q2639S7K 28929759 Patel, S; Meilandt, WJ; Erickson, RI; Chen, J; Deshmukh, G; Estrada, AA; Fuji, RN; Gibbons, P; Gustafson, A; Harris, SF; Imperio, J; Liu, W; Liu, X; Liu, Y; Lyssikatos, JP; Ma, C; Yin, J; Lewcock, JW; Siu, M WuXi AppTec Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271207&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 90292823 405255770 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50910400 Nc1ncc(cc1C(F)(F)F)-c1cc([C@@H]2[C@H]3CN(C[C@@H]23)C2COC2)n(CC2CC2)n1 InChI=1S/C21H24F3N5O/c22-21(23,24)16-3-12(5-26-20(16)25)17-4-18(29(27-17)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+ IRPVABHDSJVBNZ-QWHZDKJVSA-N 50271212 CHEMBL3715238 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.7b00843 10.7270/Q2639S7K 28929759 Patel, S; Meilandt, WJ; Erickson, RI; Chen, J; Deshmukh, G; Estrada, AA; Fuji, RN; Gibbons, P; Gustafson, A; Harris, SF; Imperio, J; Liu, W; Liu, X; Liu, Y; Lyssikatos, JP; Ma, C; Yin, J; Lewcock, JW; Siu, M WuXi AppTec Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50271212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50271212&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 90292687 405255775 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51130045 CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1 InChI=1S/C19H17N5O3S2/c1-29(26,27)24-13-5-2-4-12(8-13)9-17(25)23-19-22-16(11-28-19)15-10-21-18-14(15)6-3-7-20-18/h2-8,10-11,24H,9H2,1H3,(H,20,21)(H,22,23,25) HIUHVDROHDSKTC-UHFFFAOYSA-N 50463479 CHEMBL4249925 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2018.06.040 10.7270/Q2ZC85HX 30082069 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463479&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 6U1 5KKS 11690457 433930744 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51130337 O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1c[nH]c2ncccc12 InChI=1S/C26H29N5O2S/c32-24(31-26-30-23(17-34-26)22-16-29-25-21(22)7-2-10-28-25)15-19-4-1-6-20(14-19)33-13-3-5-18-8-11-27-12-9-18/h1-2,4,6-7,10,14,16-18,27H,3,5,8-9,11-13,15H2,(H,28,29)(H,30,31,32) OKUPZBPYLVKVSU-UHFFFAOYSA-N 50463483 CHEMBL4245242 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2018.06.040 10.7270/Q2ZC85HX 30082069 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463483&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 504 5UZK 11561968 433930748 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51130338 CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(cs3)-c3c[nH]c4ncccc34)c2)CC1 InChI=1S/C26H30N6O2S/c1-31-10-12-32(13-11-31)9-4-14-34-20-6-2-5-19(15-20)16-24(33)30-26-29-23(18-35-26)22-17-28-25-21(22)7-3-8-27-25/h2-3,5-8,15,17-18H,4,9-14,16H2,1H3,(H,27,28)(H,29,30,33) KWQRIWDMNAKJAF-UHFFFAOYSA-N 50463484 CHEMBL4248525 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2018.06.040 10.7270/Q2ZC85HX 30082069 Bandarage, UK; Cao, J; Come, JH; Court, JJ; Gao, H; Jacobs, MD; Marhefka, C; Nanthakumar, S; Green, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463484&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 6U2 5KKT 11705863 433930749 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51128294 O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 InChI=1S/C24H28N4O2S/c29-23(28-24-27-22(17-31-24)20-8-12-26-13-9-20)16-19-3-1-5-21(15-19)30-14-2-4-18-6-10-25-11-7-18/h1,3,5,8-9,12-13,15,17-18,25H,2,4,6-7,10-11,14,16H2,(H,27,28,29) IMDMAPNWXDTADU-UHFFFAOYSA-N 50462710 CHEMBL4251324 Mitogen-activated protein kinase 10 Homo sapiens >3300 ChEMBL 10.1016/j.bmcl.2018.06.043 10.7270/Q2XP77MH 29945794 Gao, H; Marhefka, C; Jacobs, MD; Cao, J; Bandarage, UK; Green, J Vertex Pharmaceuticals, Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50462710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50462710&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 65R 5HVU 60097413 433929975 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51131801 CCOc1cc(ccc1Nc1ncc2cc(C)nc(NCC(C)(C)C)c2n1)-c1nncn1C InChI=1S/C24H30N8O/c1-7-33-19-11-16(22-31-27-14-32(22)6)8-9-18(19)29-23-25-12-17-10-15(2)28-21(20(17)30-23)26-13-24(3,4)5/h8-12,14H,7,13H2,1-6H3,(H,26,28)(H,25,29,30) SGWLRDAOCLITOM-UHFFFAOYSA-N 241338 US10479788, Example 182::US11046688, Example 182::US9409907, 182 Mitogen-activated protein kinase 10 Homo sapiens 242 ChEMBL 10.1021/acs.jmedchem.8b00690 10.7270/Q2J105S9 30199249 Woodward, HL; Innocenti, P; Cheung, KJ; Hayes, A; Roberts, J; Henley, AT; Faisal, A; Mak, GW; Box, G; Westwood, IM; Cronin, N; Carter, M; Valenti, M; De Haven Brandon, A; O'Fee, L; Saville, H; Schmitt, J; Burke, R; Broccatelli, F; van Montfort, RLM; Raynaud, FI; Eccles, SA; Linardopoulos, S; Blagg, J; Hoelder, S The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=241338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=241338&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search FMW 6H3K 73386890 341093654 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51143509 O[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1 InChI=1S/C21H23F3N6O2/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29)/t12-,13-,14-/m0/s1 IBGLGMOPHJQDJB-IHRRRGAJSA-N 50364378 CHEMBL1950289 Mitogen-activated protein kinase 10 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.8b00294 10.7270/Q2XK8J7N 29969256 Juillerat-Jeanneret, L; Aubert, JD; Mikulic, J; Golshayan, D Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50364378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50364378&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search KBI 3TTI 11597537 136968440 CHEMBL1950289 ZINC35902440 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204052 Fc1ccc(cc1)-c1c(noc1-c1ccccc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C30H25FN4O2/c31-24-8-6-21(7-9-24)28-29(34-37-30(28)22-4-2-1-3-5-22)23-14-15-32-27(20-23)33-25-10-12-26(13-11-25)35-16-18-36-19-17-35/h1-15,20H,16-19H2,(H,32,33) JPHFWHGEUJYIJJ-UHFFFAOYSA-N 50495023 CHEMBL3099966 Mitogen-activated protein kinase 10 Homo sapiens >20000 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495023&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946275 433962288 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204056 Cc1ncn(n1)-c1ccc(Nc2cc(ccn2)-c2nocc2-c2cc[nH]n2)cc1 InChI=1S/C20H16N8O/c1-13-22-12-28(26-13)16-4-2-15(3-5-16)24-19-10-14(6-8-21-19)20-17(11-29-27-20)18-7-9-23-25-18/h2-12H,1H3,(H,21,24)(H,23,25) IMELNYJZDCCKFI-UHFFFAOYSA-N 50495027 CHEMBL3099964 Mitogen-activated protein kinase 10 Homo sapiens 587 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495027&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72947058 433962292 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204059 Cc1ncn(n1)-c1ccc(Nc2cc(ccn2)-c2nocc2-c2cn[nH]c2C)cc1 InChI=1S/C21H18N8O/c1-13-18(10-24-26-13)19-11-30-28-21(19)15-7-8-22-20(9-15)25-16-3-5-17(6-4-16)29-12-23-14(2)27-29/h3-12H,1-2H3,(H,22,25)(H,24,26) SNAKELXBWICEIB-UHFFFAOYSA-N 50495024 CHEMBL3100085 Mitogen-activated protein kinase 10 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495024&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946854 433962289 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204060 Cc1ncn(n1)-c1ccc(Nc2cc(ccn2)-c2nocc2-c2cnn(C)c2)cc1 InChI=1S/C21H18N8O/c1-14-23-13-29(26-14)18-5-3-17(4-6-18)25-20-9-15(7-8-22-20)21-19(12-30-27-21)16-10-24-28(2)11-16/h3-13H,1-2H3,(H,22,25) YURRRJQEDGWUNQ-UHFFFAOYSA-N 50495029 CHEMBL3100084 Mitogen-activated protein kinase 10 Homo sapiens 52 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495029&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946853 433962294 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204061 Cn1cc(cn1)-c1conc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C22H22N6O2/c1-27-14-17(13-24-27)20-15-30-26-22(20)16-6-7-23-21(12-16)25-18-2-4-19(5-3-18)28-8-10-29-11-9-28/h2-7,12-15H,8-11H2,1H3,(H,23,25) HTBUQOXMBFBWIL-UHFFFAOYSA-N 50495030 CHEMBL3099977 Mitogen-activated protein kinase 10 Homo sapiens 19 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495030&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946851 433962295 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204062 Oc1onc(c1-c1ccc(F)cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C24H21FN4O3/c25-18-3-1-16(2-4-18)22-23(28-32-24(22)30)17-9-10-26-21(15-17)27-19-5-7-20(8-6-19)29-11-13-31-14-12-29/h1-10,15,30H,11-14H2,(H,26,27) GZPFDAFEABEMRY-UHFFFAOYSA-N 50495031 CHEMBL3099975 Mitogen-activated protein kinase 10 Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495031&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946656 433962296 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204063 CN(C)CCNc1onc(c1-c1ccc(F)cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C28H31FN6O2/c1-34(2)14-13-31-28-26(20-3-5-22(29)6-4-20)27(33-37-28)21-11-12-30-25(19-21)32-23-7-9-24(10-8-23)35-15-17-36-18-16-35/h3-12,19,31H,13-18H2,1-2H3,(H,30,32) VKVNPOVQPAJWLH-UHFFFAOYSA-N 50495032 CHEMBL3099974 Mitogen-activated protein kinase 10 Homo sapiens 216 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495032&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946655 433962297 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204064 Fc1ccc(cc1)-c1c(NCc2ccccc2)onc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C31H28FN5O2/c32-25-8-6-23(7-9-25)29-30(36-39-31(29)34-21-22-4-2-1-3-5-22)24-14-15-33-28(20-24)35-26-10-12-27(13-11-26)37-16-18-38-19-17-37/h1-15,20,34H,16-19,21H2,(H,33,35) KWDPUYBWFHVCIY-UHFFFAOYSA-N 50495025 CHEMBL3099973 Mitogen-activated protein kinase 10 Homo sapiens 134 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495025&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946454 433962290 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204065 Fc1ccc(cc1)-c1conc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C24H21FN4O2/c25-19-3-1-17(2-4-19)22-16-31-28-24(22)18-9-10-26-23(15-18)27-20-5-7-21(8-6-20)29-11-13-30-14-12-29/h1-10,15-16H,11-14H2,(H,26,27) RHSCMZYLDDYLKM-UHFFFAOYSA-N 50495033 CHEMBL3099965 Mitogen-activated protein kinase 10 Homo sapiens 26 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495033&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946274 433962298 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204066 Fc1ccc(cc1)-c1c(noc1C1CC1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C27H25FN4O2/c28-21-5-3-18(4-6-21)25-26(31-34-27(25)19-1-2-19)20-11-12-29-24(17-20)30-22-7-9-23(10-8-22)32-13-15-33-16-14-32/h3-12,17,19H,1-2,13-16H2,(H,29,30) FRQAHATZTUYBKE-UHFFFAOYSA-N 50495034 CHEMBL3099967 Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495034&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946276 433962299 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204067 CNc1onc(c1-c1ccc(F)cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C25H24FN5O2/c1-27-25-23(17-2-4-19(26)5-3-17)24(30-33-25)18-10-11-28-22(16-18)29-20-6-8-21(9-7-20)31-12-14-32-15-13-31/h2-11,16,27H,12-15H2,1H3,(H,28,29) SUSNDQCWEIEVDO-UHFFFAOYSA-N 50495035 CHEMBL3099972 Mitogen-activated protein kinase 10 Homo sapiens 27 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495035&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946453 433962300 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204080 Cc1ncn(n1)-c1ccc(Nc2cc(ccn2)-c2nocc2-c2cn[nH]c2)cc1 InChI=1S/C20H16N8O/c1-13-22-12-28(26-13)17-4-2-16(3-5-17)25-19-8-14(6-7-21-19)20-18(11-29-27-20)15-9-23-24-10-15/h2-12H,1H3,(H,21,25)(H,23,24) YFPHGGTUESKWNB-UHFFFAOYSA-N 50495036 CHEMBL3099963 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495036&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946856 433962301 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204081 Cc1ncn(n1)-c1ccc(Nc2cc(ccn2)-c2nocc2-c2c(C)n[nH]c2C)cc1 InChI=1S/C22H20N8O/c1-13-21(14(2)27-26-13)19-11-31-29-22(19)16-8-9-23-20(10-16)25-17-4-6-18(7-5-17)30-12-24-15(3)28-30/h4-12H,1-3H3,(H,23,25)(H,26,27) RLTYMZOLUUHEKX-UHFFFAOYSA-N 50495037 CHEMBL3100086 Mitogen-activated protein kinase 10 Homo sapiens 187 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495037&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946855 433962302 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204082 Fc1ccc(cc1)-c1c(noc1N1CCOCC1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C28H28FN5O3/c29-22-3-1-20(2-4-22)26-27(32-37-28(26)34-13-17-36-18-14-34)21-9-10-30-25(19-21)31-23-5-7-24(8-6-23)33-11-15-35-16-12-33/h1-10,19H,11-18H2,(H,30,31) OQNXCPKEFDUABP-UHFFFAOYSA-N 50495022 CHEMBL3099970 Mitogen-activated protein kinase 10 Homo sapiens 523 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495022&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946451 433962287 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204089 Cc1ncn(n1)-c1ccc(Nc2cc(ccn2)-c2nocc2C)cc1 InChI=1S/C18H16N6O/c1-12-10-25-23-18(12)14-7-8-19-17(9-14)21-15-3-5-16(6-4-15)24-11-20-13(2)22-24/h3-11H,1-2H3,(H,19,21) UTGPUHPCLJSYPL-UHFFFAOYSA-N 50495028 CHEMBL3099976 Mitogen-activated protein kinase 10 Homo sapiens 435 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495028&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946661 433962293 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204090 Cc1onc(c1-c1ccc(F)cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C25H23FN4O2/c1-17-24(18-2-4-20(26)5-3-18)25(29-32-17)19-10-11-27-23(16-19)28-21-6-8-22(9-7-21)30-12-14-31-15-13-30/h2-11,16H,12-15H2,1H3,(H,27,28) OLSHHRXKZFBOEQ-UHFFFAOYSA-N 50495040 CHEMBL3099968 Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495040&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946277 433962305 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204091 Fc1ccc(cc1)-c1n[nH]cc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C24H22FN5O/c25-19-3-1-17(2-4-19)24-22(16-27-29-24)18-9-10-26-23(15-18)28-20-5-7-21(8-6-20)30-11-13-31-14-12-30/h1-10,15-16H,11-14H2,(H,26,28)(H,27,29) HKNAFPFXVBINRD-UHFFFAOYSA-N 50495026 CHEMBL3099962 Mitogen-activated protein kinase 10 Homo sapiens 7.0 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495026&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 76328237 433962291 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204092 C1CC1c1conc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C21H22N4O2/c1-2-15(1)19-14-27-24-21(19)16-7-8-22-20(13-16)23-17-3-5-18(6-4-17)25-9-11-26-12-10-25/h3-8,13-15H,1-2,9-12H2,(H,22,23) SCZZQTKTFQIQPX-UHFFFAOYSA-N 50495038 CHEMBL3100083 Mitogen-activated protein kinase 10 Homo sapiens 74 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495038&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946852 433962303 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204093 Fc1ccc(cc1)-c1c(noc1C#N)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C25H20FN5O2/c26-19-3-1-17(2-4-19)24-22(16-27)33-30-25(24)18-9-10-28-23(15-18)29-20-5-7-21(8-6-20)31-11-13-32-14-12-31/h1-10,15H,11-14H2,(H,28,29) QETNKKQHGNSASN-UHFFFAOYSA-N 50495041 CHEMBL3099969 Mitogen-activated protein kinase 10 Homo sapiens 126 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495041&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946450 433962306 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51204094 CN(C)c1onc(c1-c1ccc(F)cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C26H26FN5O2/c1-31(2)26-24(18-3-5-20(27)6-4-18)25(30-34-26)19-11-12-28-23(17-19)29-21-7-9-22(10-8-21)32-13-15-33-16-14-32/h3-12,17H,13-16H2,1-2H3,(H,28,29) SAHIOUDYBIEVOE-UHFFFAOYSA-N 50495039 CHEMBL3099971 Mitogen-activated protein kinase 10 Homo sapiens 366 ChEMBL 10.1016/j.bmcl.2013.11.052 10.7270/Q2XG9V3X 24332487 He, Y; Duckett, D; Chen, W; Ling, YY; Cameron, MD; Lin, L; Ruiz, CH; Lograsso, PV; Kamenecka, TM; Koenig, M The Scripps Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50495039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50495039&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 72946452 433962304 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51217232 C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F InChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1 VRQXRVAKPDCRCI-ZNMIVQPWSA-N 106870 US8592455, 70 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01275 10.7270/Q2H41VGN 26505898 Burger, MT; Nishiguchi, G; Han, W; Lan, J; Simmons, R; Atallah, G; Ding, Y; Tamez, V; Zhang, Y; Mathur, M; Muller, K; Bellamacina, C; Lindvall, MK; Zang, R; Huh, K; Feucht, P; Zavorotinskaya, T; Dai, Y; Basham, S; Chan, J; Ginn, E; Aycinena, A; Holash, J; Castillo, J; Langowski, JL; Wang, Y; Chen, MY; Lambert, A; Fritsch, C; Kauffmann, A; Pfister, E; Vanasse, KG; Garcia, PD Novartis Institutes for Biomedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106870&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5H7 5DWR 44814409 174009181 ZINC96177711 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261189 Cc1cccc(\N=C2\NC(=O)\C(S2)=C2\C(=O)Nc3ccccc23)c1C InChI=1S/C19H15N3O2S/c1-10-6-5-9-13(11(10)2)21-19-22-18(24)16(25-19)15-12-7-3-4-8-14(12)20-17(15)23/h3-9H,1-2H3,(H,20,23)(H,21,22,24)/b16-15- MNHUQNMQMMLMNL-NXVVXOECSA-N 50515260 CHEMBL4451516 Mitogen-activated protein kinase 10 Homo sapiens 1830 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515260&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 746075 440723842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261191 Clc1ccc(cc1)C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C16H11ClN2O2/c17-11-7-5-10(6-8-11)15(20)9-14-16(21)19-13-4-2-1-3-12(13)18-14/h1-9,18H,(H,19,21)/b14-9- CWZOPSSVGBGCBS-ZROIWOOFSA-N 50515261 CHEMBL4560317 Mitogen-activated protein kinase 10 Homo sapiens 8890 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515261&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135432695 440723843 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261193 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)NCC1CCNCC1 InChI=1S/C23H25ClN6O2/c24-20-6-1-2-7-21(20)29-23(32)28-18-14-27-30(15-18)19-5-3-4-17(12-19)22(31)26-13-16-8-10-25-11-9-16/h1-7,12,14-16,25H,8-11,13H2,(H,26,31)(H2,28,29,32) XDNOBDTYZKRSTK-UHFFFAOYSA-N 50032750 CHEMBL3355181 Mitogen-activated protein kinase 10 Homo sapiens 206 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032750&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 86763302 103941205 CHEMBL3355181 ZINC13742728 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261195 COc1ccc(cc1OC)-c1n[nH]cc1\C=N/NC(=O)c1ccccc1I InChI=1S/C19H17IN4O3/c1-26-16-8-7-12(9-17(16)27-2)18-13(10-21-23-18)11-22-24-19(25)14-5-3-4-6-15(14)20/h3-11H,1-2H3,(H,21,23)(H,24,25)/b22-11- VGIMUSVKXGHFOE-JJFYIABZSA-N 50515262 CHEMBL4449405 Mitogen-activated protein kinase 10 Homo sapiens 7650 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515262&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135533810 440723844 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261196 O=C(\C=C1/Nc2ccccc2NC1=O)c1cccc2ccccc12 InChI=1S/C20H14N2O2/c23-19(15-9-5-7-13-6-1-2-8-14(13)15)12-18-20(24)22-17-11-4-3-10-16(17)21-18/h1-12,21H,(H,22,24)/b18-12- ZMFVICCTJZQVDM-PDGQHHTCSA-N 50515263 CHEMBL4531109 Mitogen-activated protein kinase 10 Homo sapiens 250 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515263&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135883136 440723845 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261197 COc1cc(ccc1O)-c1nc2ccccn2c1\N=C\c1c[nH]nc1-c1ccccc1 InChI=1S/C24H19N5O2/c1-31-20-13-17(10-11-19(20)30)23-24(29-12-6-5-9-21(29)27-23)25-14-18-15-26-28-22(18)16-7-3-2-4-8-16/h2-15,30H,1H3,(H,26,28)/b25-14+ VMDKSSAVTNXHFI-AFUMVMLFSA-N 50515264 CHEMBL4533188 Mitogen-activated protein kinase 10 Homo sapiens 4240 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515264&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135446691 440723846 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261198 O=C1NC(=O)\C(S1)=C1\C(=O)Nc2ccccc12 InChI=1S/C11H6N2O3S/c14-9-7(8-10(15)13-11(16)17-8)5-3-1-2-4-6(5)12-9/h1-4H,(H,12,14)(H,13,15,16)/b8-7- SKRVRVSQHUZLBW-FPLPWBNLSA-N 50515265 CHEMBL1213862 Mitogen-activated protein kinase 10 Homo sapiens 6570 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515265&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1641795 440723847 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261199 Cc1c(Cl)cccc1\N=C1\NC(=O)\C(S1)=C1\C(=O)Nc2ccc(Br)cc12 InChI=1S/C18H11BrClN3O2S/c1-8-11(20)3-2-4-12(8)22-18-23-17(25)15(26-18)14-10-7-9(19)5-6-13(10)21-16(14)24/h2-7H,1H3,(H,21,24)(H,22,23,25)/b15-14- LJGZDRTVFZHIGJ-PFONDFGASA-N 50515266 CHEMBL4531954 Mitogen-activated protein kinase 10 Homo sapiens 350 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515266&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1228716 440723848 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261200 Cc1ccc(cc1Cl)\N=C1\NC(=O)\C(S1)=C1\C(=O)Nc2ccc(I)cc12 InChI=1S/C18H11ClIN3O2S/c1-8-2-4-10(7-12(8)19)21-18-23-17(25)15(26-18)14-11-6-9(20)3-5-13(11)22-16(14)24/h2-7H,1H3,(H,22,24)(H,21,23,25)/b15-14- VQAAUHHAHNBKHU-PFONDFGASA-N 50515267 CHEMBL4470329 Mitogen-activated protein kinase 10 Homo sapiens 1900 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515267&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1228584 440723849 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261201 O=C(\C=C1/Nc2ccccc2NC1=O)c1ccccc1 InChI=1S/C16H12N2O2/c19-15(11-6-2-1-3-7-11)10-14-16(20)18-13-9-5-4-8-12(13)17-14/h1-10,17H,(H,18,20)/b14-10- VYSUSLXZOLRSEX-UVTDQMKNSA-N 50515268 CHEMBL4483382 Mitogen-activated protein kinase 10 Homo sapiens 2370 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515268&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135454192 440723850 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261202 C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H10N2/c1-2-6-11-9(4-1)8-10-5-3-7-12-13(10)14(11)16-15-12/h1-7H,8H2,(H,15,16) SLMJDPXFWRYMLU-UHFFFAOYSA-N 50515269 CHEMBL4462592 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515269&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155529132 440723851 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261210 Cc1c(Cl)cccc1\N=C1\NC(=O)\C(S1)=C1\C(=O)Nc2ccccc12 InChI=1S/C18H12ClN3O2S/c1-9-11(19)6-4-8-12(9)21-18-22-17(24)15(25-18)14-10-5-2-3-7-13(10)20-16(14)23/h2-8H,1H3,(H,20,23)(H,21,22,24)/b15-14- DFBCRGBYBJYDRL-PFONDFGASA-N 50515270 CHEMBL4464624 Mitogen-activated protein kinase 10 Homo sapiens 620 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515270&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1228713 440723852 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261212 Brc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N/c3cccc4ccccc34)c2c1 InChI=1S/C21H12BrN3O2S/c22-12-8-9-16-14(10-12)17(19(26)23-16)18-20(27)25-21(28-18)24-15-7-3-5-11-4-1-2-6-13(11)15/h1-10H,(H,23,26)(H,24,25,27)/b18-17- QYFOETBWCJXBPR-ZCXUNETKSA-N 50515271 CHEMBL4551217 Mitogen-activated protein kinase 10 Homo sapiens 590 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515271&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1228882 440723853 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261214 Clc1cccc(c1)\N=C1\NC(=O)\C(S1)=C1\C(=O)Nc2ccc(I)cc12 InChI=1S/C17H9ClIN3O2S/c18-8-2-1-3-10(6-8)20-17-22-16(24)14(25-17)13-11-7-9(19)4-5-12(11)21-15(13)23/h1-7H,(H,21,23)(H,20,22,24)/b14-13- IPGMJSWQKCJPGC-YPKPFQOOSA-N 50515272 CHEMBL4442806 Mitogen-activated protein kinase 10 Homo sapiens 750 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515272&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1737773 440723854 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261218 Clc1ccccc1\N=C1/NC(=O)\C(S1)=C\C=C\c1ccccc1 InChI=1S/C18H13ClN2OS/c19-14-10-4-5-11-15(14)20-18-21-17(22)16(23-18)12-6-9-13-7-2-1-3-8-13/h1-12H,(H,20,21,22)/b9-6+,16-12- NKIWWRJRKUNSDM-FLIHGVEMSA-N 50515273 CHEMBL4483514 Mitogen-activated protein kinase 10 Homo sapiens 9760 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515273&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135417092 440723855 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261219 COc1ccc(\C=C/C(=O)c2c(-c3ccccc3)c3cc(C)ccc3[nH]c2=O)cc1 InChI=1S/C26H21NO3/c1-17-8-14-22-21(16-17)24(19-6-4-3-5-7-19)25(26(29)27-22)23(28)15-11-18-9-12-20(30-2)13-10-18/h3-16H,1-2H3,(H,27,29)/b15-11- OJMCCNQNCSCAJV-PTNGSMBKSA-N 50515274 CHEMBL4461363 Mitogen-activated protein kinase 10 Homo sapiens 14190 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515274&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5337145 440723856 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261220 COc1ccc(cc1)S(=O)(=O)\N=C1\NC(=O)\C(S1)=C1\C(=O)Nc2ccc(Br)cc12 InChI=1S/C18H12BrN3O5S2/c1-27-10-3-5-11(6-4-10)29(25,26)22-18-21-17(24)15(28-18)14-12-8-9(19)2-7-13(12)20-16(14)23/h2-8H,1H3,(H,20,23)(H,21,22,24)/b15-14- NYRBFXPKDAPCFB-PFONDFGASA-N 50515275 CHEMBL4579302 Mitogen-activated protein kinase 10 Homo sapiens 2430 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515275&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1208196 440723857 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51261223 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N/c3ccccc3Cl)c2c1 InChI=1S/C17H9ClFN3O2S/c18-10-3-1-2-4-12(10)21-17-22-16(24)14(25-17)13-9-7-8(19)5-6-11(9)20-15(13)23/h1-7H,(H,20,23)(H,21,22,24)/b14-13- HNOFQKYBQYGFNQ-YPKPFQOOSA-N 50515259 CHEMBL4470981 Mitogen-activated protein kinase 10 Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.9b00537 10.7270/Q2SF30H3 31268308 Dou, X; Huang, H; Li, Y; Jiang, L; Wang, Y; Jin, H; Jiao, N; Zhang, L; Zhang, L; Liu, Z Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515259&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 4078145 440723841 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237944 O=C(Cc1ccc(cc1)-c1ccccc1)Nc1cc([nH]n1)C1CCC1 InChI=1S/C21H21N3O/c25-21(22-20-14-19(23-24-20)18-7-4-8-18)13-15-9-11-17(12-10-15)16-5-2-1-3-6-16/h1-3,5-6,9-12,14,18H,4,7-8,13H2,(H2,22,23,24,25) DTNFOGMAASDEQI-UHFFFAOYSA-N 50506700 CHEMBL4439395 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.10.020 10.7270/Q26M3B39 30343954 Rana, S; Sonawane, YA; Taylor, MA; Kizhake, S; Zahid, M; Natarajan, A Eppley Institute for Research in Cancer and Allied Diseases http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506700&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 69762142 440715285 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237968 O\N=C1\c2ccccc2-c2nc3ccc(cc3nc12)C(O)=O InChI=1S/C16H9N3O3/c20-16(21)8-5-6-11-12(7-8)18-15-13(17-11)9-3-1-2-4-10(9)14(15)19-22/h1-7,22H,(H,20,21)/b19-14- PYABQVKREKYNJT-RGEXLXHISA-N 50506714 CHEMBL4553054 Mitogen-activated protein kinase 10 Homo sapiens 3900 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506714&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155555966 440715299 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237969 OC(=O)CO\N=C1/c2ccccc2-c2nc3ccccc3nc12 InChI=1S/C17H11N3O3/c21-14(22)9-23-20-16-11-6-2-1-5-10(11)15-17(16)19-13-8-4-3-7-12(13)18-15/h1-8H,9H2,(H,21,22)/b20-16+ FYPYRKHDUUOAMZ-CAPFRKAQSA-N 50506713 CHEMBL4541080 Mitogen-activated protein kinase 10 Homo sapiens 28500 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506713&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155551144 440715298 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237991 Cc1cc2nc3\C(=N/O)c4ccccc4-c3nc2cc1C InChI=1S/C17H13N3O/c1-9-7-13-14(8-10(9)2)19-17-15(18-13)11-5-3-4-6-12(11)16(17)20-21/h3-8,21H,1-2H3/b20-16- NERJSNYOGGKVRR-SILNSSARSA-N 50506715 CHEMBL4449918 Mitogen-activated protein kinase 10 Homo sapiens 1300 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506715&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155521400 440715300 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237992 Cc1ccc2nc3\C(=N/O)c4ccccc4-c3nc2c1 InChI=1S/C16H11N3O/c1-9-6-7-12-13(8-9)18-14-10-4-2-3-5-11(10)15(19-20)16(14)17-12/h2-8,20H,1H3/b19-15- APPUPKYUHWUPCJ-CYVLTUHYSA-N 50506716 CHEMBL4521282 Mitogen-activated protein kinase 10 Homo sapiens 340 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506716&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155542557 440715301 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237993 O\N=C1\c2ccccc2-c2nc3cc(Cl)ccc3nc12 InChI=1S/C15H8ClN3O/c16-8-5-6-11-12(7-8)18-13-9-3-1-2-4-10(9)14(19-20)15(13)17-11/h1-7,20H/b19-14- UUCUQQSPAIGSDY-RGEXLXHISA-N 50506712 CHEMBL4583031 Mitogen-activated protein kinase 10 Homo sapiens 710 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506712&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155565897 440715297 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237994 O\N=C1\c2ccccc2-c2nc3ncccc3nc12 InChI=1S/C14H8N4O/c19-18-12-9-5-2-1-4-8(9)11-13(12)16-10-6-3-7-15-14(10)17-11/h1-7,19H/b18-12- XURAVYGNAAUXQP-PDGQHHTCSA-N 50506725 CHEMBL4593099 Mitogen-activated protein kinase 10 Homo sapiens 390 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506725&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155569233 440715310 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237995 O\N=C1\c2ccccc2-c2nc3ncc(Cl)cc3nc12 InChI=1S/C14H7ClN4O/c15-7-5-10-14(16-6-7)18-11-8-3-1-2-4-9(8)12(19-20)13(11)17-10/h1-6,20H/b19-12- XOSPTXXKPUNNKX-UNOMPAQXSA-N 50506719 CHEMBL4457644 Mitogen-activated protein kinase 10 Homo sapiens 2900 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506719&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155525801 440715304 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237996 CCOC(=O)CO\N=C1/c2ccccc2-c2nc3ccccc3nc12 InChI=1S/C19H15N3O3/c1-2-24-16(23)11-25-22-18-13-8-4-3-7-12(13)17-19(18)21-15-10-6-5-9-14(15)20-17/h3-10H,2,11H2,1H3/b22-18+ BTJOSZCOBPWUOW-RELWKKBWSA-N 50506721 CHEMBL4582239 Mitogen-activated protein kinase 10 Homo sapiens 76 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506721&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155561957 440715306 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237997 OCCO\N=C1/c2ccccc2-c2nc3ccccc3nc12 InChI=1S/C17H13N3O2/c21-9-10-22-20-16-12-6-2-1-5-11(12)15-17(16)19-14-8-4-3-7-13(14)18-15/h1-8,21H,9-10H2/b20-16+ IJJGKDJYHVEPCJ-CAPFRKAQSA-N 50506724 CHEMBL4536915 Mitogen-activated protein kinase 10 Homo sapiens 310 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506724&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155548073 440715309 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237998 O\N=C1/c2ccccc2-c2nc3ccccc3nc12 InChI=1S/C15H9N3O/c19-18-14-10-6-2-1-5-9(10)13-15(14)17-12-8-4-3-7-11(12)16-13/h1-8,19H/b18-14+ SZHHSFHOIDCNLD-NBVRZTHBSA-N 50506717 CHEMBL3759098 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506717&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 619002 440715302 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51237999 O\N=C1/c2ccccc2-n2c1nc1ccccc1c2=O InChI=1S/C15H9N3O2/c19-15-9-5-1-3-7-11(9)16-14-13(17-20)10-6-2-4-8-12(10)18(14)15/h1-8,20H/b17-13+ PMNWPSRSXHKOQI-GHRIWEEISA-N 50506718 CHEMBL1098827 Mitogen-activated protein kinase 10 Homo sapiens 275 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506718&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 44313624 440715303 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51238035 Cc1cccc2nc3\C(=N/O)c4ccccc4-c3nc12 InChI=1S/C16H11N3O/c1-9-5-4-8-12-13(9)18-14-10-6-2-3-7-11(10)15(19-20)16(14)17-12/h2-8,20H,1H3/b19-15- ZJWZDMQTDMVQQB-CYVLTUHYSA-N 50506722 CHEMBL4439862 Mitogen-activated protein kinase 10 Homo sapiens 6000 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506722&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155514086 440715307 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51238036 CCOc1ccc2nc3\C(=N/O)c4ccccc4-c3nc2c1 InChI=1S/C17H13N3O2/c1-2-22-10-7-8-13-14(9-10)19-15-11-5-3-4-6-12(11)16(20-21)17(15)18-13/h3-9,21H,2H2,1H3/b20-16- LFOJUDSZVVWDAJ-SILNSSARSA-N 50506726 CHEMBL4524938 Mitogen-activated protein kinase 10 Homo sapiens 910 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506726&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155538719 440715311 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51238037 O\N=C1\c2ccccc2-c2nc3ccncc3nc12 InChI=1S/C14H8N4O/c19-18-13-9-4-2-1-3-8(9)12-14(13)17-11-7-15-6-5-10(11)16-12/h1-7,19H/b18-13- DGYKSZOQVJDTRZ-AQTBWJFISA-N 50506720 CHEMBL4514173 Mitogen-activated protein kinase 10 Homo sapiens 280 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506720&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155539342 440715305 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51238038 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 22 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51238048 O\N=C1\c2ccccc2-c2nc3ccc(cc3nc12)[N+]([O-])=O InChI=1S/C15H8N4O3/c20-18-14-10-4-2-1-3-9(10)13-15(14)17-12-7-8(19(21)22)5-6-11(12)16-13/h1-7,20H/b18-14- KVZSJRZDWSIABG-JXAWBTAJSA-N 50506723 CHEMBL4474210 Mitogen-activated protein kinase 10 Homo sapiens 4300 ChEMBL 10.1016/j.ejmech.2018.10.023 10.7270/Q2TB1B58 30347329 Schepetkin, IA; Khlebnikov, AI; Potapov, AS; Kovrizhina, AR; Matveevskaya, VV; Belyanin, ML; Atochin, DN; Zanoza, SO; Gaidarzhy, NM; Lyakhov, SA; Kirpotina, LN; Quinn, MT Montana State University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50506723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50506723&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155536948 440715308 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51234564 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)CCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F InChI=1S/C50H56BF2N7O7/c1-30-26-31(2)59-39(30)27-33-15-14-32(60(33)51(59,52)53)16-17-41(61)54-18-20-64-22-24-66-25-23-65-21-19-56(4)40-28-42-57-37-12-8-6-10-34(37)44-45-36(29-55-49(45)62)43-35-11-7-9-13-38(35)58(47(43)46(44)57)50(3,67-42)48(40)63-5/h6-15,26-27,40,42,48H,16-25,28-29H2,1-5H3,(H,54,61)(H,55,62)/t40-,42-,48-,50+/m1/s1 OSVUGUHRKMMBSE-INMRTLOZSA-N 50505542 CHEMBL4576489 Mitogen-activated protein kinase 10 Homo sapiens 245 ChEMBL 10.1016/j.bmcl.2019.126641 10.7270/Q2RV0S0K 31526603 Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505542&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155552127 440714127 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51234671 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)NCCOCCOCCOCCNC(=O)CCC1=[N+]2C(C=C1)=Cc1c(C)cc(C)n1[B-]2(F)F InChI=1S/C49H54BF2N7O7/c1-29-25-30(2)58-39(29)26-32-14-13-31(59(32)50(58,51)52)15-16-40(60)54-18-20-64-22-24-65-23-21-63-19-17-53-36-27-41-56-37-11-7-5-9-33(37)43-44-35(28-55-48(44)61)42-34-10-6-8-12-38(34)57(46(42)45(43)56)49(3,66-41)47(36)62-4/h5-14,25-26,36,41,47,53H,15-24,27-28H2,1-4H3,(H,54,60)(H,55,61)/t36-,41-,47-,49+/m1/s1 NXSJMRCTGYTSTK-SQHKIPTKSA-N 50505541 CHEMBL4465866 Mitogen-activated protein kinase 10 Homo sapiens 315 ChEMBL 10.1016/j.bmcl.2019.126641 10.7270/Q2RV0S0K 31526603 Hirozane, Y; Toyofuku, M; Yogo, T; Tanaka, Y; Sameshima, T; Miyahisa, I; Yoshikawa, M Takeda Pharmaceutical Company Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50505541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50505541&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155531579 440714126 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51222470 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(CCN(C)C)CCc3n2)ncc1F InChI=1S/C27H32F2N8/c1-16(2)37-17(3)31-26-20(28)12-19(13-23(26)37)25-21(29)14-30-27(34-25)33-24-7-6-18-15-36(11-10-35(4)5)9-8-22(18)32-24/h6-7,12-14,16H,8-11,15H2,1-5H3,(H,30,32,33,34) KGMVZSJAPXYTKH-UHFFFAOYSA-N 444543 US10662186, Compound 63::US10988476, Compound I-63 Mitogen-activated protein kinase 10 Homo sapiens 416 ChEMBL 10.1016/j.ejmech.2019.06.005 10.7270/Q20K2CTJ 31200237 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Han, Y; Xiao, W; Wang, Z; Shi, W; Mao, Y; Yu, J; Xia, G; Liu, Y Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=444543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=444543&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 130196825 440706790 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51252998 C[C@@H](Oc1cc(ccc1Nc1nc(O[C@H]2CC[C@@](C)(O)CC2)c2c(Cl)c[nH]c2n1)C(=O)N(C)C)C(F)(F)F InChI=1S/C25H29ClF3N5O4/c1-13(25(27,28)29)37-18-11-14(22(35)34(3)4)5-6-17(18)31-23-32-20-19(16(26)12-30-20)21(33-23)38-15-7-9-24(2,36)10-8-15/h5-6,11-13,15,36H,7-10H2,1-4H3,(H2,30,31,32,33)/t13-,15-,24+/m1/s1 IUWWRSQCDUQDEZ-CAQPCFEESA-N 50512318 CHEMBL4546504 Mitogen-activated protein kinase 10 Homo sapiens 0.107000 ChEMBL 10.1021/acs.jmedchem.8b01869 10.7270/Q2KS6VVN 30998356 Riggs, JR; Elsner, J; Cashion, D; Robinson, D; Tehrani, L; Nagy, M; Fultz, KE; Krishna Narla, R; Peng, X; Tran, T; Kulkarni, A; Bahmanyar, S; Condroski, K; Pagarigan, B; Fenalti, G; LeBrun, L; Leftheris, K; Zhu, D; Boylan, JF Celgene Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50512318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50512318&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search KE7 6N6O 138320062 440720900 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51238616 CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23) KQMPRSZTUSSXND-UHFFFAOYSA-N 15908 Aminopyridine-Based Inhibitor 6o::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide::aminopyridine deriv. 2 Mitogen-activated protein kinase 10 Homo sapiens 257 ChEMBL 10.1016/j.ejmech.2018.10.052 10.7270/Q2W380MT 30384048 Narayan, S; Ramisetti, S; Jaiswal, AS; Law, BK; Singh-Pillay, A; Singh, P; Amin, S; Sharma, AK University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15908&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11624601 46516179 5998 ZINC14959960 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51273009 CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32) WVGDUQVQWLHVEA-UHFFFAOYSA-N 50519662 CHEMBL4438748 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.9b01143 10.7270/Q2MC93FG 31693351 Zhao, L; Li, Y; Wang, Y; Qiao, Z; Miao, Z; Yang, J; Huang, L; Tian, C; Li, L; Chen, D; Yang, S TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50519662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50519662&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155513187 440728244 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51277012 CS(=O)(=O)Nc1cc(cnc1Cl)-c1ccncc1 InChI=1S/C11H10ClN3O2S/c1-18(16,17)15-10-6-9(7-14-11(10)12)8-2-4-13-5-3-8/h2-7,15H,1H3 KDSFLYIZGIJKAW-UHFFFAOYSA-N 50521216 CHEMBL4474208 Mitogen-activated protein kinase 10 Homo sapiens <10000 ChEMBL 10.1021/acs.jmedchem.8b01556 10.7270/Q2Z60SFQ 30532965 Barton, N; Convery, M; Cooper, AWJ; Down, K; Hamblin, JN; Inglis, G; Peace, S; Rowedder, J; Rowland, P; Taylor, JA; Wellaway, N GlaxoSmithKline R&D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521216&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155537016 440729798 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51311376 COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@@H](O)CO)ccn1 InChI=1S/C30H34N2O6/c1-36-29-13-24(8-9-28(29)38-18-20-2-4-22(5-3-20)23-6-7-23)25-14-32(15-25)30(35)27-12-21(10-11-31-27)17-37-19-26(34)16-33/h2-5,8-13,23,25-26,33-34H,6-7,14-19H2,1H3/t26-/m0/s1 LTTJGQBDGMNWHJ-SANMLTNESA-N 50532181 CHEMBL4474690 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2019.02.006 10.7270/Q22F7RXK 30755337 Ikegashira, K; Ikenogami, T; Yamasaki, T; Oka, T; Hase, Y; Miyagawa, N; Inagaki, K; Kawahara, I; Koga, Y; Hashimoto, H Japan Tobacco Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50532181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50532181&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search A7O 6IG8 49806372 440740763 C02773 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51300463 CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23) KQMPRSZTUSSXND-UHFFFAOYSA-N 15908 Aminopyridine-Based Inhibitor 6o::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide::aminopyridine deriv. 2 Mitogen-activated protein kinase 10 Homo sapiens 770 ChEMBL 10.1016/j.ejmech.2018.11.037 10.7270/Q2TQ650N 30530196 Venkanna, A; Cho, KH; Dhorma, LP; Kumar, DN; Hah, JM; Park, HG; Kim, SY; Kim, MH Gachon University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15908&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11624601 46516179 5998 ZINC14959960 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51300471 CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23) KQMPRSZTUSSXND-UHFFFAOYSA-N 15908 Aminopyridine-Based Inhibitor 6o::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide::aminopyridine deriv. 2 Mitogen-activated protein kinase 10 Homo sapiens 770 ChEMBL 10.1016/j.ejmech.2018.11.037 10.7270/Q2TQ650N 30530196 Venkanna, A; Cho, KH; Dhorma, LP; Kumar, DN; Hah, JM; Park, HG; Kim, SY; Kim, MH Gachon University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15908&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11624601 46516179 5998 ZINC14959960 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50483959 C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 InChI=1S/C19H23N7O/c1-12-6-15(12)19(27)26-5-4-25(10-13(26)2)17-9-21-16(7-20)18(23-17)14-8-22-24(3)11-14/h8-9,11-13,15H,4-6,10H2,1-3H3/t12-,13-,15-/m1/s1 GXEXIUKEWXZCEF-UMVBOHGHSA-N 50537742 CHEMBL4634634::US11179389, Compound 1-14 Mitogen-activated protein kinase 10 Homo sapiens 5370 ChEMBL 10.1016/j.bmcl.2019.126715 10.7270/Q2HM5CZG 31757666 Zhou, H; McGowan, MA; Lipford, K; Christopher, M; Fradera, X; Witter, D; Lesburg, CA; Li, C; Methot, JL; Lampe, J; Achab, A; Shaffer, L; Goldenblatt, P; Shah, S; Bass, A; Schroeder, G; Chen, D; Zeng, H; Augustin, MA; Katz, JD Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537742&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5D 6OCU 145704650 442139305 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51329047 C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 InChI=1S/C19H23N7O/c1-12-6-15(12)19(27)26-5-4-25(10-13(26)2)17-9-21-16(7-20)18(23-17)14-8-22-24(3)11-14/h8-9,11-13,15H,4-6,10H2,1-3H3/t12-,13-,15-/m1/s1 GXEXIUKEWXZCEF-UMVBOHGHSA-N 50537742 CHEMBL4634634::US11179389, Compound 1-14 Mitogen-activated protein kinase 10 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2019.126715 10.7270/Q2HM5CZG 31757666 Zhou, H; McGowan, MA; Lipford, K; Christopher, M; Fradera, X; Witter, D; Lesburg, CA; Li, C; Methot, JL; Lampe, J; Achab, A; Shaffer, L; Goldenblatt, P; Shah, S; Bass, A; Schroeder, G; Chen, D; Zeng, H; Augustin, MA; Katz, JD Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537742&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 5D 6OCU 145704650 442139305 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50079443 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Mitogen-activated protein kinase 10 Homo sapiens <1000 ChEMBL 10.1021/acs.jmedchem.9b00058 10.7270/Q24170ZD 30978288 Roy, SM; Minasov, G; Arancio, O; Chico, LW; Van Eldik, LJ; Anderson, WF; Pelletier, JC; Watterson, DM Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50079444 C[S+]([O-])c1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1 50045333 CHEBI:90705::SB-203580 Mitogen-activated protein kinase 10 Homo sapiens <1000 ChEMBL 10.1021/acs.jmedchem.9b00058 10.7270/Q24170ZD 30978288 Roy, SM; Minasov, G; Arancio, O; Chico, LW; Van Eldik, LJ; Anderson, WF; Pelletier, JC; Watterson, DM Northwestern University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50045333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50045333&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 176155 313068400 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51392137 O=C1COC2(C=CC(=O)C=C2)N1c1nc(nn1-c1ccccc1)-c1cccc2ccccc12 InChI=1S/C26H18N4O3/c31-20-13-15-26(16-14-20)29(23(32)17-33-26)25-27-24(28-30(25)19-9-2-1-3-10-19)22-12-6-8-18-7-4-5-11-21(18)22/h1-16H,17H2 NSWXPDNYWQZXRX-UHFFFAOYSA-N 50562523 CHEMBL4756015 Mitogen-activated protein kinase 10 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2020.113039 10.7270/Q2W66QHF 33261898 Luo, L; Jia, JJ; Zhong, Q; Zhong, X; Zheng, S; Wang, G; He, L Sichuan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50562523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50562523&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162655252 461832915 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384773 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cc(cs1)C(=O)NC1CNC1 InChI=1S/C18H17ClN6O2S/c19-14-3-1-2-4-15(14)24-18(27)23-13-8-21-25(9-13)16-5-11(10-28-16)17(26)22-12-6-20-7-12/h1-5,8-10,12,20H,6-7H2,(H,22,26)(H2,23,24,27) VBQBWSUTLCKKFK-UHFFFAOYSA-N 50559418 CHEMBL4777114 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559418&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162643535 461829810 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384774 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1ccc(s1)C(=O)NC1CNC1 InChI=1S/C18H17ClN6O2S/c19-13-3-1-2-4-14(13)24-18(27)23-12-9-21-25(10-12)16-6-5-15(28-16)17(26)22-11-7-20-8-11/h1-6,9-11,20H,7-8H2,(H,22,26)(H2,23,24,27) SKRFBRFSMJDVQF-UHFFFAOYSA-N 50559442 CHEMBL4744126 Mitogen-activated protein kinase 10 Homo sapiens 800 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559442&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162646198 461829834 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384775 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1nc(cs1)C(=O)NC1CNC1 InChI=1S/C17H16ClN7O2S/c18-12-3-1-2-4-13(12)23-16(27)22-11-7-20-25(8-11)17-24-14(9-28-17)15(26)21-10-5-19-6-10/h1-4,7-10,19H,5-6H2,(H,21,26)(H2,22,23,27) HPWXLXQYIXNWKX-UHFFFAOYSA-N 50559443 CHEMBL4791169 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559443&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162671411 461829835 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384776 Cc1sc(cc1-n1cc(NC(=O)Nc2c(F)cccc2Cl)cn1)C(=O)N[C@@H]1CCOC1 InChI=1S/C20H19ClFN5O3S/c1-11-16(7-17(31-11)19(28)24-12-5-6-30-10-12)27-9-13(8-23-27)25-20(29)26-18-14(21)3-2-4-15(18)22/h2-4,7-9,12H,5-6,10H2,1H3,(H,24,28)(H2,25,26,29)/t12-/m1/s1 VPVAOTNNZQMZSM-GFCCVEGCSA-N 50559419 CHEMBL4749547 Mitogen-activated protein kinase 10 Homo sapiens 53 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559419&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162651427 461829811 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384777 Cc1sc(cc1-n1cc(NC(=O)Nc2c(F)cccc2Cl)cn1)C(=O)NC1COC1 InChI=1S/C19H17ClFN5O3S/c1-10-15(5-16(30-10)18(27)23-12-8-29-9-12)26-7-11(6-22-26)24-19(28)25-17-13(20)3-2-4-14(17)21/h2-7,12H,8-9H2,1H3,(H,23,27)(H2,24,25,28) JRCVTCDIBTUNEL-UHFFFAOYSA-N 50559420 CHEMBL4784092 Mitogen-activated protein kinase 10 Homo sapiens 67 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559420&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search X3S 7KSI 155803725 461829812 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384778 Fc1ccc(NC(=O)Nc2cnn(c2)-c2csc(c2)C(=O)NC2COC2)c(Cl)c1 InChI=1S/C18H15ClFN5O3S/c19-14-3-10(20)1-2-15(14)24-18(27)23-11-5-21-25(6-11)13-4-16(29-9-13)17(26)22-12-7-28-8-12/h1-6,9,12H,7-8H2,(H,22,26)(H2,23,24,27) VIWCTPHOGOQOTQ-UHFFFAOYSA-N 50559421 CHEMBL4754908 Mitogen-activated protein kinase 10 Homo sapiens 53 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559421&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162654617 461829813 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384779 Fc1cccc(Cl)c1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C18H15ClFN5O3S/c19-13-2-1-3-14(20)16(13)24-18(27)23-10-5-21-25(6-10)12-4-15(29-9-12)17(26)22-11-7-28-8-11/h1-6,9,11H,7-8H2,(H,22,26)(H2,23,24,27) ANCCTLHKRLRSAF-UHFFFAOYSA-N 50559422 CHEMBL4778645 Mitogen-activated protein kinase 10 Homo sapiens 33 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559422&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search X3Y 7KSJ 155803726 461829814 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384780 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)NCC1CCOCC1 InChI=1S/C21H22ClN5O3S/c22-17-3-1-2-4-18(17)26-21(29)25-15-11-24-27(12-15)16-9-19(31-13-16)20(28)23-10-14-5-7-30-8-6-14/h1-4,9,11-14H,5-8,10H2,(H,23,28)(H2,25,26,29) LIWQYJBFPZCBRH-UHFFFAOYSA-N 50559423 CHEMBL4744992 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559423&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162648614 461829815 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384781 CN1CCC[C@H]1CNC(=O)c1cc(cs1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C21H23ClN6O2S/c1-27-8-4-5-15(27)11-23-20(29)19-9-16(13-31-19)28-12-14(10-24-28)25-21(30)26-18-7-3-2-6-17(18)22/h2-3,6-7,9-10,12-13,15H,4-5,8,11H2,1H3,(H,23,29)(H2,25,26,30)/t15-/m0/s1 ICEHLXOJLXPHOH-HNNXBMFYSA-N 50559424 CHEMBL4798047 Mitogen-activated protein kinase 10 Homo sapiens 85 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559424&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162675120 461829816 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384782 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)NC[C@H]1CCOC1 InChI=1S/C20H20ClN5O3S/c21-16-3-1-2-4-17(16)25-20(28)24-14-9-23-26(10-14)15-7-18(30-12-15)19(27)22-8-13-5-6-29-11-13/h1-4,7,9-10,12-13H,5-6,8,11H2,(H,22,27)(H2,24,25,28)/t13-/m1/s1 SCEDADZCWDKRNJ-CYBMUJFWSA-N 50559425 CHEMBL4755895 Mitogen-activated protein kinase 10 Homo sapiens 71 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559425&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162655326 461829817 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384783 CN1CC[C@H](CNC(=O)c2cc(cs2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)C1 InChI=1S/C21H23ClN6O2S/c1-27-7-6-14(11-27)9-23-20(29)19-8-16(13-31-19)28-12-15(10-24-28)25-21(30)26-18-5-3-2-4-17(18)22/h2-5,8,10,12-14H,6-7,9,11H2,1H3,(H,23,29)(H2,25,26,30)/t14-/m1/s1 ZILWEQNTUQYRDZ-CQSZACIVSA-N 50559426 CHEMBL4753218 Mitogen-activated protein kinase 10 Homo sapiens 222 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559426&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162653793 461829818 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384784 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)NCC1CCNCC1 InChI=1S/C21H23ClN6O2S/c22-17-3-1-2-4-18(17)27-21(30)26-15-11-25-28(12-15)16-9-19(31-13-16)20(29)24-10-14-5-7-23-8-6-14/h1-4,9,11-14,23H,5-8,10H2,(H,24,29)(H2,26,27,30) KDKBDYGQYOQREK-UHFFFAOYSA-N 50559427 CHEMBL4788258 Mitogen-activated protein kinase 10 Homo sapiens 186 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559427&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162668733 461829819 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384785 CN1CCC(CNC(=O)c2cc(cs2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)CC1 InChI=1S/C22H25ClN6O2S/c1-28-8-6-15(7-9-28)11-24-21(30)20-10-17(14-32-20)29-13-16(12-25-29)26-22(31)27-19-5-3-2-4-18(19)23/h2-5,10,12-15H,6-9,11H2,1H3,(H,24,30)(H2,26,27,31) ZCXZADLHKFAMEG-UHFFFAOYSA-N 50559428 CHEMBL4754031 Mitogen-activated protein kinase 10 Homo sapiens 142 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559428&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162654922 461829820 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384786 CC1(COC1)NC(=O)c1cc(cs1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C19H18ClN5O3S/c1-19(10-28-11-19)24-17(26)16-6-13(9-29-16)25-8-12(7-21-25)22-18(27)23-15-5-3-2-4-14(15)20/h2-9H,10-11H2,1H3,(H,24,26)(H2,22,23,27) JNLMFIFNLPZEAY-UHFFFAOYSA-N 50559429 CHEMBL4758113 Mitogen-activated protein kinase 10 Homo sapiens 45 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559429&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162656541 461829821 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384787 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C18H16ClN5O3S/c19-14-3-1-2-4-15(14)23-18(26)22-11-6-20-24(7-11)13-5-16(28-10-13)17(25)21-12-8-27-9-12/h1-7,10,12H,8-9H2,(H,21,25)(H2,22,23,26) FPVKFPPNOMNINZ-UHFFFAOYSA-N 50559430 CHEMBL4753641 Mitogen-activated protein kinase 10 Homo sapiens 35 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559430&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search X3V 7KSK 155803727 461829822 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384788 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)N[C@@H]1CCOC1 InChI=1S/C19H18ClN5O3S/c20-15-3-1-2-4-16(15)24-19(27)23-13-8-21-25(9-13)14-7-17(29-11-14)18(26)22-12-5-6-28-10-12/h1-4,7-9,11-12H,5-6,10H2,(H,22,26)(H2,23,24,27)/t12-/m1/s1 NDXBTYNWEFNKOR-GFCCVEGCSA-N 50559431 CHEMBL4753310 Mitogen-activated protein kinase 10 Homo sapiens 8.0 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559431&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162653834 461829823 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384789 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)NC1CCOCC1 InChI=1S/C20H20ClN5O3S/c21-16-3-1-2-4-17(16)25-20(28)24-14-10-22-26(11-14)15-9-18(30-12-15)19(27)23-13-5-7-29-8-6-13/h1-4,9-13H,5-8H2,(H,23,27)(H2,24,25,28) CXHIICHKQPOOEC-UHFFFAOYSA-N 50559432 CHEMBL4762965 Mitogen-activated protein kinase 10 Homo sapiens 50 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559432&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162659646 461829824 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384790 CN1CCC(CC1)NC(=O)c1cc(cs1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C21H23ClN6O2S/c1-27-8-6-14(7-9-27)24-20(29)19-10-16(13-31-19)28-12-15(11-23-28)25-21(30)26-18-5-3-2-4-17(18)22/h2-5,10-14H,6-9H2,1H3,(H,24,29)(H2,25,26,30) IHRCFUDNMXTGNY-UHFFFAOYSA-N 50559433 CHEMBL4759538 Mitogen-activated protein kinase 10 Homo sapiens 84 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559433&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162658274 461829825 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384791 CC(C)N1CC[C@@H](C1)NC(=O)c1cc(cs1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C22H25ClN6O2S/c1-14(2)28-8-7-15(11-28)25-21(30)20-9-17(13-32-20)29-12-16(10-24-29)26-22(31)27-19-6-4-3-5-18(19)23/h3-6,9-10,12-15H,7-8,11H2,1-2H3,(H,25,30)(H2,26,27,31)/t15-/m0/s1 DDIMQPXLFWQMIR-HNNXBMFYSA-N 50559434 CHEMBL4784095 Mitogen-activated protein kinase 10 Homo sapiens 12 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559434&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162666023 461829826 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384792 CN1CC[C@@H](C1)NC(=O)c1cc(cs1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C20H21ClN6O2S/c1-26-7-6-13(10-26)23-19(28)18-8-15(12-30-18)27-11-14(9-22-27)24-20(29)25-17-5-3-2-4-16(17)21/h2-5,8-9,11-13H,6-7,10H2,1H3,(H,23,28)(H2,24,25,29)/t13-/m0/s1 PSPGYOROKVJHTA-ZDUSSCGKSA-N 50559435 CHEMBL4754584 Mitogen-activated protein kinase 10 Homo sapiens 39 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559435&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162655003 461829827 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384793 [2H]C([2H])([2H])N1CC[C@H](C1)NC(=O)c1cc(cs1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C20H21ClN6O2S/c1-26-7-6-13(10-26)23-19(28)18-8-15(12-30-18)27-11-14(9-22-27)24-20(29)25-17-5-3-2-4-16(17)21/h2-5,8-9,11-13H,6-7,10H2,1H3,(H,23,28)(H2,24,25,29)/t13-/m1/s1/i1D3 PSPGYOROKVJHTA-JJMJVRKHSA-N 50559436 CHEMBL4799926 Mitogen-activated protein kinase 10 Homo sapiens 83 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559436&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162677373 461829828 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384794 CN1CC[C@H](C1)NC(=O)c1cc(cs1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C20H21ClN6O2S/c1-26-7-6-13(10-26)23-19(28)18-8-15(12-30-18)27-11-14(9-22-27)24-20(29)25-17-5-3-2-4-16(17)21/h2-5,8-9,11-13H,6-7,10H2,1H3,(H,23,28)(H2,24,25,29)/t13-/m1/s1 PSPGYOROKVJHTA-CYBMUJFWSA-N 50559437 CHEMBL4745961 Mitogen-activated protein kinase 10 Homo sapiens 85 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559437&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162647868 461829829 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384795 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)N[C@@H]1CCNC1 InChI=1S/C19H19ClN6O2S/c20-15-3-1-2-4-16(15)25-19(28)24-13-9-22-26(10-13)14-7-17(29-11-14)18(27)23-12-5-6-21-8-12/h1-4,7,9-12,21H,5-6,8H2,(H,23,27)(H2,24,25,28)/t12-/m1/s1 FCHPGFCBVJEMLI-GFCCVEGCSA-N 50559438 CHEMBL4758690 Mitogen-activated protein kinase 10 Homo sapiens 132 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559438&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162658457 461829830 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384796 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)NC1CC1 InChI=1S/C18H16ClN5O2S/c19-14-3-1-2-4-15(14)23-18(26)22-12-8-20-24(9-12)13-7-16(27-10-13)17(25)21-11-5-6-11/h1-4,7-11H,5-6H2,(H,21,25)(H2,22,23,26) MJPWAJUXPIZNIX-UHFFFAOYSA-N 50559439 CHEMBL4793809 Mitogen-activated protein kinase 10 Homo sapiens 80 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559439&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162672730 461829831 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384797 CNC(=O)c1cc(cs1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1 InChI=1S/C16H14ClN5O2S/c1-18-15(23)14-6-11(9-25-14)22-8-10(7-19-22)20-16(24)21-13-5-3-2-4-12(13)17/h2-9H,1H3,(H,18,23)(H2,20,21,24) WYRYAZSGQNDTJW-UHFFFAOYSA-N 50559440 CHEMBL4757583 Mitogen-activated protein kinase 10 Homo sapiens 118 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559440&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162656361 461829832 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51384798 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)NC1CNC1 InChI=1S/C18H17ClN6O2S/c19-14-3-1-2-4-15(14)24-18(27)23-12-8-21-25(9-12)13-5-16(28-10-13)17(26)22-11-6-20-7-11/h1-5,8-11,20H,6-7H2,(H,22,26)(H2,23,24,27) ZFCITVDGKUVOJP-UHFFFAOYSA-N 50559441 CHEMBL4783382 Mitogen-activated protein kinase 10 Homo sapiens 50 ChEMBL 10.1021/acsmedchemlett.0c00533 10.7270/Q2KW5KRN 33488960 Feng, Y; Park, H; Bauer, L; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559441&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162666179 461829833 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51385379 CC(C)Nc1nccc(n1)-c1c(nn2ccccc12)C1CC1 InChI=1S/C17H19N5/c1-11(2)19-17-18-9-8-13(20-17)15-14-5-3-4-10-22(14)21-16(15)12-6-7-12/h3-5,8-12H,6-7H2,1-2H3,(H,18,19,20) XPSBHTFYQLTERF-UHFFFAOYSA-N 50559722 CHEMBL4777781 Mitogen-activated protein kinase 10 Homo sapiens 1200 ChEMBL 10.1021/acs.jmedchem.9b02170 10.7270/Q2W95DVV 32255344 Peng, T; Qi, B; He, J; Ke, H; Shi, J Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559722&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 49800137 461830114 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51385384 C[S+]([O-])c1nc(c(-c2ccc(NC(C)=O)nc2)n1C)-c1ccc(F)cc1 InChI=1S/C18H17FN4O2S/c1-11(24)21-15-9-6-13(10-20-15)17-16(12-4-7-14(19)8-5-12)22-18(23(17)2)26(3)25/h4-10H,1-3H3,(H,20,21,24) GCFIASDOZHNRKP-UHFFFAOYSA-N 50559688 CHEMBL4747276 Mitogen-activated protein kinase 10 Homo sapiens 700 ChEMBL 10.1021/acs.jmedchem.9b02170 10.7270/Q2W95DVV 32255344 Peng, T; Qi, B; He, J; Ke, H; Shi, J Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559688&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162649217 461830080 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51390374 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ RADRIIWGHYFWPP-WEVVVXLNSA-N 86632 JNK-IN-7 Mitogen-activated protein kinase 10 Homo sapiens 0.750000 ChEMBL 10.1021/acsmedchemlett.0c00378 10.7270/Q2N01B75 33214835 Hatcher, JM; Yang, G; Wang, L; Ficarro, SB; Buhrlage, S; Wu, H; Marto, JA; Treon, SP; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340685 136352681 ZINC87723492 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51366795 NC(=O)c1sc(nc1OCCCC1CCN(Cc2ccc(F)cc2)CC1)-c1ccnc(NC(=O)C2CC2)c1 InChI=1S/C28H32FN5O3S/c29-22-7-3-19(4-8-22)17-34-13-10-18(11-14-34)2-1-15-37-27-24(25(30)35)38-28(33-27)21-9-12-31-23(16-21)32-26(36)20-5-6-20/h3-4,7-9,12,16,18,20H,1-2,5-6,10-11,13-15,17H2,(H2,30,35)(H,31,32,36) LQLBWZJHRARWDB-UHFFFAOYSA-N 50552452 CHEMBL4747992 Mitogen-activated protein kinase 10 Homo sapiens >300 ChEMBL 10.1016/j.bmc.2020.115940 10.7270/Q20K2D6W 33340937 Jiang, X; Wang, Y; Liu, C; Xing, C; Wang, Y; Lyu, W; Wang, S; Li, Q; Chen, T; Chen, Y; Feng, F; Liu, W; Sun, H China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50552452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50552452&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156165678 461682792 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51360668 Cc1ccnc(NC(=O)Cc2ccc3ccccc3c2)c1 InChI=1S/C18H16N2O/c1-13-8-9-19-17(10-13)20-18(21)12-14-6-7-15-4-2-3-5-16(15)11-14/h2-11H,12H2,1H3,(H,19,20,21) HPQZTEVMVAVGJO-UHFFFAOYSA-N 50550127 CHEMBL4781866 Mitogen-activated protein kinase 10 Homo sapiens 4700 ChEMBL 10.1039/d0md00292e 10.7270/Q2251NSH 34046605 Wang, CB; Lorente-Macías, Á; Wells, C; Pickett, JE; Picado, A; Zuercher, WJ; Axtman, AD University of North Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50550127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50550127&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25348574 461680467 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51360669 COc1ccnc(NC(=O)Cc2ccc3ccccc3c2)c1 InChI=1S/C18H16N2O2/c1-22-16-8-9-19-17(12-16)20-18(21)11-13-6-7-14-4-2-3-5-15(14)10-13/h2-10,12H,11H2,1H3,(H,19,20,21) LGUXBXKDCLNCEH-UHFFFAOYSA-N 50550129 CHEMBL4744511 Mitogen-activated protein kinase 10 Homo sapiens 1300 ChEMBL 10.1039/d0md00292e 10.7270/Q2251NSH 34046605 Wang, CB; Lorente-Macías, Á; Wells, C; Pickett, JE; Picado, A; Zuercher, WJ; Axtman, AD University of North Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50550129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50550129&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search UGS 5RGY 146037575 461680469 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51360670 Clc1ccnc(NC(=O)Cc2ccc3ccccc3c2)c1 InChI=1S/C17H13ClN2O/c18-15-7-8-19-16(11-15)20-17(21)10-12-5-6-13-3-1-2-4-14(13)9-12/h1-9,11H,10H2,(H,19,20,21) UPVVKGJGCKBECE-UHFFFAOYSA-N 50550131 CHEMBL4754904 Mitogen-activated protein kinase 10 Homo sapiens 520 ChEMBL 10.1039/d0md00292e 10.7270/Q2251NSH 34046605 Wang, CB; Lorente-Macías, Á; Wells, C; Pickett, JE; Picado, A; Zuercher, WJ; Axtman, AD University of North Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50550131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50550131&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 115626700 461680471 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51360671 COc1ccc2cc(ccc2c1)C(C)C(=O)Nc1cc(C)ccn1 InChI=1S/C20H20N2O2/c1-13-8-9-21-19(10-13)22-20(23)14(2)15-4-5-17-12-18(24-3)7-6-16(17)11-15/h4-12,14H,1-3H3,(H,21,22,23) QUOGFPPPCZTQAX-UHFFFAOYSA-N 50550132 CHEMBL4749658 Mitogen-activated protein kinase 10 Homo sapiens 780 ChEMBL 10.1039/d0md00292e 10.7270/Q2251NSH 34046605 Wang, CB; Lorente-Macías, Á; Wells, C; Pickett, JE; Picado, A; Zuercher, WJ; Axtman, AD University of North Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50550132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50550132&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 42919272 461680472 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51360672 COc1ccc2cc(ccc2c1)[C@H](C)C(=O)Nc1cc(C)ccn1 InChI=1S/C20H20N2O2/c1-13-8-9-21-19(10-13)22-20(23)14(2)15-4-5-17-12-18(24-3)7-6-16(17)11-15/h4-12,14H,1-3H3,(H,21,22,23)/t14-/m0/s1 QUOGFPPPCZTQAX-AWEZNQCLSA-N 50550133 CHEMBL4754518 Mitogen-activated protein kinase 10 Homo sapiens 5100 ChEMBL 10.1039/d0md00292e 10.7270/Q2251NSH 34046605 Wang, CB; Lorente-Macías, Á; Wells, C; Pickett, JE; Picado, A; Zuercher, WJ; Axtman, AD University of North Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50550133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50550133&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25344970 461680473 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51360690 Cc1ccnc(NC(=O)Cc2ccc3ccccc3c2)c1 InChI=1S/C18H16N2O/c1-13-8-9-19-17(10-13)20-18(21)12-14-6-7-15-4-2-3-5-16(15)11-14/h2-11H,12H2,1H3,(H,19,20,21) HPQZTEVMVAVGJO-UHFFFAOYSA-N 50550127 CHEMBL4781866 Mitogen-activated protein kinase 10 Homo sapiens 340 ChEMBL 10.1039/d0md00292e 10.7270/Q2251NSH 34046605 Wang, CB; Lorente-Macías, Á; Wells, C; Pickett, JE; Picado, A; Zuercher, WJ; Axtman, AD University of North Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50550127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50550127&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25348574 461680467 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51359883 Cc1nc(NC(=O)NCCc2cn(CC(F)F)cn2)sc1C#Cc1cccnc1 InChI=1S/C19H18F2N6OS/c1-13-16(5-4-14-3-2-7-22-9-14)29-19(25-13)26-18(28)23-8-6-15-10-27(12-24-15)11-17(20)21/h2-3,7,9-10,12,17H,6,8,11H2,1H3,(H2,23,25,26,28) FUKVQYDAJUEJHW-UHFFFAOYSA-N 50549828 CHEMBL4795990 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549828&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 49847093 461680168 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51359884 COc1cc(cnc1OC)C#Cc1sc(NC(=O)NCCOCC2CC2)nc1C InChI=1S/C20H24N4O4S/c1-13-17(7-6-15-10-16(26-2)18(27-3)22-11-15)29-20(23-13)24-19(25)21-8-9-28-12-14-4-5-14/h10-11,14H,4-5,8-9,12H2,1-3H3,(H2,21,23,24,25) NXINHUNNPLATCI-UHFFFAOYSA-N 50549837 CHEMBL4759283 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549837&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 59615740 461680177 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51359885 Cc1nc(NC(=O)NCCOCC2CC2)sc1C#Cc1ccc2cncn2c1 InChI=1S/C20H21N5O2S/c1-14-18(7-5-15-4-6-17-10-21-13-25(17)11-15)28-20(23-14)24-19(26)22-8-9-27-12-16-2-3-16/h4,6,10-11,13,16H,2-3,8-9,12H2,1H3,(H2,22,23,24,26) HSBRXTBEKJPMLK-UHFFFAOYSA-N 50549846 CHEMBL4764646 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549846&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162661364 461680186 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51359886 C[C@@H](CNC(=O)Nc1nc(C)c(s1)C#Cc1cncc(C)c1)OCC1CC1 InChI=1S/C20H24N4O2S/c1-13-8-17(11-21-9-13)6-7-18-15(3)23-20(27-18)24-19(25)22-10-14(2)26-12-16-4-5-16/h8-9,11,14,16H,4-5,10,12H2,1-3H3,(H2,22,23,24,25)/t14-/m0/s1 MFIXITNFFHIALQ-AWEZNQCLSA-N 50549854 CHEMBL4784202 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549854&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162665555 461680194 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51359887 C[C@@H](CNC(=O)Nc1nc(C)c(s1)C#Cc1cnc(C)c(C)c1)OCC1CC1 InChI=1S/C21H26N4O2S/c1-13-9-18(11-22-15(13)3)7-8-19-16(4)24-21(28-19)25-20(26)23-10-14(2)27-12-17-5-6-17/h9,11,14,17H,5-6,10,12H2,1-4H3,(H2,23,24,25,26)/t14-/m0/s1 OZANXNDKKYVVMJ-AWEZNQCLSA-N 50549855 CHEMBL4756664 Mitogen-activated protein kinase 10 Homo sapiens >4000 ChEMBL 10.1021/acsmedchemlett.0c00573 10.7270/Q2HD8081 33488974 Bandarage, UK; Aronov, AM; Cao, J; Come, JH; Cottrell, KM; Davies, RJ; Giroux, S; Jacobs, M; Mahajan, S; Messersmith, D; Moody, CS; Swett, R; Xu, J Vertex Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549855&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162655372 461680195 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398770 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398771 O=C(\C=C1/Nc2ccccc2NC1=O)c1cccc2ccccc12 InChI=1S/C20H14N2O2/c23-19(15-9-5-7-13-6-1-2-8-14(13)15)12-18-20(24)22-17-11-4-3-10-16(17)21-18/h1-12,21H,(H,22,24)/b18-12- ZMFVICCTJZQVDM-PDGQHHTCSA-N 50515263 CHEMBL4531109 Mitogen-activated protein kinase 10 Homo sapiens 250 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515263&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135883136 440723845 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398772 Clc1ccccc1C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C16H11ClN2O2/c17-11-6-2-1-5-10(11)15(20)9-14-16(21)19-13-8-4-3-7-12(13)18-14/h1-9,18H,(H,19,21)/b14-9- KNEOVAHITUYEHR-ZROIWOOFSA-N 50565120 CHEMBL4782208 Mitogen-activated protein kinase 10 Homo sapiens 410 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565120&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135678353 461685458 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398773 Brc1ccccc1C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C16H11BrN2O2/c17-11-6-2-1-5-10(11)15(20)9-14-16(21)19-13-8-4-3-7-12(13)18-14/h1-9,18H,(H,19,21)/b14-9- DNKWPZRRBPHEAD-ZROIWOOFSA-N 50565121 CHEMBL4799531 Mitogen-activated protein kinase 10 Homo sapiens 1330 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565121&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137244227 461685459 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398774 Cc1ccccc1C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C17H14N2O2/c1-11-6-2-3-7-12(11)16(20)10-15-17(21)19-14-9-5-4-8-13(14)18-15/h2-10,18H,1H3,(H,19,21)/b15-10- RUCKREZLHBQANC-GDNBJRDFSA-N 50565122 CHEMBL4789089 Mitogen-activated protein kinase 10 Homo sapiens 3480 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565122&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137244230 461685460 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398775 COc1ccccc1C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C17H14N2O3/c1-22-16-9-5-2-6-11(16)15(20)10-14-17(21)19-13-8-4-3-7-12(13)18-14/h2-10,18H,1H3,(H,19,21)/b14-10- DSGAIZZRSFFBNV-UVTDQMKNSA-N 50565123 CHEMBL4785607 Mitogen-activated protein kinase 10 Homo sapiens 1430 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565123&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135713004 461685461 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398776 Nc1ccccc1C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C16H13N3O2/c17-11-6-2-1-5-10(11)15(20)9-14-16(21)19-13-8-4-3-7-12(13)18-14/h1-9,18H,17H2,(H,19,21)/b14-9- WARPLCQHAJUBCN-ZROIWOOFSA-N 50565124 CHEMBL4780101 Mitogen-activated protein kinase 10 Homo sapiens 1750 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565124&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137244228 461685462 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398777 Clc1cccc(c1)C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C16H11ClN2O2/c17-11-5-3-4-10(8-11)15(20)9-14-16(21)19-13-7-2-1-6-12(13)18-14/h1-9,18H,(H,19,21)/b14-9- YSEBPFBXVWYGRO-ZROIWOOFSA-N 50565125 CHEMBL4777530 Mitogen-activated protein kinase 10 Homo sapiens 370 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565125&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135453970 461685463 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398778 Cc1cccc(c1)C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C17H14N2O2/c1-11-5-4-6-12(9-11)16(20)10-15-17(21)19-14-8-3-2-7-13(14)18-15/h2-10,18H,1H3,(H,19,21)/b15-10- ALSPYHLHFHALBH-GDNBJRDFSA-N 50565126 CHEMBL4788894 Mitogen-activated protein kinase 10 Homo sapiens 320 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565126&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162670136 461685464 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398779 COc1cccc(c1)C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C17H14N2O3/c1-22-12-6-4-5-11(9-12)16(20)10-15-17(21)19-14-8-3-2-7-13(14)18-15/h2-10,18H,1H3,(H,19,21)/b15-10- BZENEAZERGFZTJ-GDNBJRDFSA-N 50565127 CHEMBL4781949 Mitogen-activated protein kinase 10 Homo sapiens 5600 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565127&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135538546 461685465 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398780 Nc1cccc(c1)C(=O)\C=C1/Nc2ccccc2NC1=O InChI=1S/C16H13N3O2/c17-11-5-3-4-10(8-11)15(20)9-14-16(21)19-13-7-2-1-6-12(13)18-14/h1-9,18H,17H2,(H,19,21)/b14-9- NZYLDVWVFWCIRY-ZROIWOOFSA-N 50565128 CHEMBL4800639 Mitogen-activated protein kinase 10 Homo sapiens 600 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565128&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162677405 461685466 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398781 CC(C)(C)OC(=O)N\C=C1/Nc2ccccc2NC1=O InChI=1S/C14H17N3O3/c1-14(2,3)20-13(19)15-8-11-12(18)17-10-7-5-4-6-9(10)16-11/h4-8,16H,1-3H3,(H,15,19)(H,17,18)/b11-8- YDVUYBQSIVHMFR-FLIBITNWSA-N 50565129 CHEMBL4794586 Mitogen-activated protein kinase 10 Homo sapiens 5150 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565129&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162674176 461685467 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398782 Clc1cccc(C(=O)\C=C2/Nc3ccccc3NC2=O)c1Cl InChI=1S/C16H10Cl2N2O2/c17-10-5-3-4-9(15(10)18)14(21)8-13-16(22)20-12-7-2-1-6-11(12)19-13/h1-8,19H,(H,20,22)/b13-8- SVNHGWNBISNBMG-JYRVWZFOSA-N 50565130 CHEMBL4782076 Mitogen-activated protein kinase 10 Homo sapiens 430 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565130&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162665009 461685468 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398783 O=C(\C=C1/Nc2cc(ccc2NC1=O)C#N)c1cccc2ccccc12 InChI=1S/C21H13N3O2/c22-12-13-8-9-17-18(10-13)23-19(21(26)24-17)11-20(25)16-7-3-5-14-4-1-2-6-15(14)16/h1-11,23H,(H,24,26)/b19-11- LLVGRQUDHSCNNV-ODLFYWEKSA-N 50565131 CHEMBL4795574 Mitogen-activated protein kinase 10 Homo sapiens 190 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565131&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162674227 461685469 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398784 Clc1ccccc1C(=O)\C=C1/Nc2cc(ccc2NC1=O)C#N InChI=1S/C17H10ClN3O2/c18-12-4-2-1-3-11(12)16(22)8-15-17(23)21-13-6-5-10(9-19)7-14(13)20-15/h1-8,20H,(H,21,23)/b15-8- XQMNWMCDNKNJMB-NVNXTCNLSA-N 50565132 CHEMBL4794035 Mitogen-activated protein kinase 10 Homo sapiens 1680 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565132&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162672997 461685470 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398785 Brc1ccccc1C(=O)\C=C1/Nc2cc(ccc2NC1=O)C#N InChI=1S/C17H10BrN3O2/c18-12-4-2-1-3-11(12)16(22)8-15-17(23)21-13-6-5-10(9-19)7-14(13)20-15/h1-8,20H,(H,21,23)/b15-8- PNCCVGKQEYVMCU-NVNXTCNLSA-N 50565133 CHEMBL4793426 Mitogen-activated protein kinase 10 Homo sapiens 4780 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565133&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162674274 461685471 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51398786 COc1ccccc1C(=O)\C=C1/Nc2cc(ccc2NC1=O)C#N InChI=1S/C18H13N3O3/c1-24-17-5-3-2-4-12(17)16(22)9-15-18(23)21-13-7-6-11(10-19)8-14(13)20-15/h2-9,20H,1H3,(H,21,23)/b15-9- WFHVALQFRODLAX-DHDCSXOGSA-N 50565134 CHEMBL4776996 Mitogen-activated protein kinase 10 Homo sapiens 7370 ChEMBL 10.1016/j.ejmech.2020.112445 10.7270/Q2K07819 32603981 Dou, X; Huang, H; Jiang, L; Zhu, G; Jin, H; Jiao, N; Zhang, L; Liu, Z; Zhang, L Peking University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565134&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162642871 461685472 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51422452 CS(=O)(=O)c1nccc(n1)-c1c(nc2sccn12)-c1cccc(OCc2ccccc2)c1 InChI=1S/C23H18N4O3S2/c1-32(28,29)22-24-11-10-19(25-22)21-20(26-23-27(21)12-13-31-23)17-8-5-9-18(14-17)30-15-16-6-3-2-4-7-16/h2-14H,15H2,1H3 DQOWVAQFOQHAFL-UHFFFAOYSA-N 50574707 CHEMBL4860202 Mitogen-activated protein kinase 10 Homo sapiens 5199 ChEMBL 10.1016/j.ejmech.2021.113674 10.7270/Q28K7DVS 34237622 Zaraei, SO; Sbenati, RM; Alach, NN; Anbar, HS; El-Gamal, R; Tarazi, H; Shehata, MK; Abdel-Maksoud, MS; Oh, CH; El-Gamal, MI Korea Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574707&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155804973 471064852 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51422453 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Mitogen-activated protein kinase 10 Homo sapiens 73 ChEMBL 10.1016/j.ejmech.2021.113674 10.7270/Q28K7DVS 34237622 Zaraei, SO; Sbenati, RM; Alach, NN; Anbar, HS; El-Gamal, R; Tarazi, H; Shehata, MK; Abdel-Maksoud, MS; Oh, CH; El-Gamal, MI Korea Institute of Science and Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search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itogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429772 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)Nc1cnn(c1)C1CCNC1 InChI=1S/C24H23ClN8O2/c25-21-6-1-2-7-22(21)31-24(35)30-18-12-27-32(15-18)19-5-3-4-16(10-19)23(34)29-17-11-28-33(14-17)20-8-9-26-13-20/h1-7,10-12,14-15,20,26H,8-9,13H2,(H,29,34)(H2,30,31,35) IMARJVJNXLXPIX-UHFFFAOYSA-N 50032821 CHEMBL3355178 Mitogen-activated protein kinase 10 Homo sapiens <1.000000 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032821&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 3NL 4WHZ 101891709 312528608 CHEMBL3355178 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429773 Clc1ccccc1NC(=O)Nc1cnn(c1)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C18H16ClN5O3S/c19-14-3-1-2-4-15(14)23-18(26)22-11-6-20-24(7-11)13-5-16(28-10-13)17(25)21-12-8-27-9-12/h1-7,10,12H,8-9H2,(H,21,25)(H2,22,23,26) FPVKFPPNOMNINZ-UHFFFAOYSA-N 50559430 CHEMBL4753641 Mitogen-activated protein kinase 10 Homo sapiens 35 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50559430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50559430&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search X3V 7KSK 155803727 461829822 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429774 CNC(=O)c1cc(cs1)-n1ncc2nc(Nc3ccccc3Cl)ncc12 InChI=1S/C17H13ClN6OS/c1-19-16(25)15-6-10(9-26-15)24-14-8-20-17(23-13(14)7-21-24)22-12-5-3-2-4-11(12)18/h2-9H,1H3,(H,19,25)(H,20,22,23) MIRKUAGPNQXHEP-UHFFFAOYSA-N 50577618 CHEMBL4862159 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577618&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155295 471053741 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429775 Clc1ccccc1Nc1ccc2n(ncc2n1)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C20H16ClN5O2S/c21-14-3-1-2-4-15(14)24-19-6-5-17-16(25-19)8-22-26(17)13-7-18(29-11-13)20(27)23-12-9-28-10-12/h1-8,11-12H,9-10H2,(H,23,27)(H,24,25) AXBGXSIGWZPTCE-UHFFFAOYSA-N 50577619 CHEMBL4853789 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577619&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155325 471053742 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429776 Clc1ccccc1Nc1cc2cnn(-c3csc(c3)C(=O)NC3COC3)c2cn1 InChI=1S/C20H16ClN5O2S/c21-15-3-1-2-4-16(15)25-19-5-12-7-23-26(17(12)8-22-19)14-6-18(29-11-14)20(27)24-13-9-28-10-13/h1-8,11,13H,9-10H2,(H,22,25)(H,24,27) XXPJQSSWRLLVEZ-UHFFFAOYSA-N 50577620 CHEMBL4872832 Mitogen-activated protein kinase 10 Homo sapiens 5.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577620&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155321 471053743 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429777 Clc1ccccc1Nc1cnc2n(ncc2c1)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C20H16ClN5O2S/c21-16-3-1-2-4-17(16)24-13-5-12-7-23-26(19(12)22-8-13)15-6-18(29-11-15)20(27)25-14-9-28-10-14/h1-8,11,14,24H,9-10H2,(H,25,27) AJMFKZZQEDNOJZ-UHFFFAOYSA-N 50577621 CHEMBL4872493 Mitogen-activated protein kinase 10 Homo sapiens 6.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577621&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156165218 471053744 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429778 Fc1cc2n(ncc2cc1Nc1ccccc1Cl)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C21H16ClFN4O2S/c22-15-3-1-2-4-17(15)26-18-5-12-8-24-27(19(12)7-16(18)23)14-6-20(30-11-14)21(28)25-13-9-29-10-13/h1-8,11,13,26H,9-10H2,(H,25,28) NVZWLMGDVMWXOW-UHFFFAOYSA-N 50577622 CHEMBL4847784 Mitogen-activated protein kinase 10 Homo sapiens 14 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577622&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155347 471053745 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429779 Fc1cc2n(ncc2cc1Nc1ccccc1Cl)-c1csc(c1)C(=O)N[C@H]1CCOC1 InChI=1S/C22H18ClFN4O2S/c23-16-3-1-2-4-18(16)27-19-7-13-10-25-28(20(13)9-17(19)24)15-8-21(31-12-15)22(29)26-14-5-6-30-11-14/h1-4,7-10,12,14,27H,5-6,11H2,(H,26,29)/t14-/m0/s1 FSGQLCRNDPQFNY-AWEZNQCLSA-N 50577623 CHEMBL4874575 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577623&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155317 471053746 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429780 Fc1cc2n(ncc2cc1Nc1ccccc1Cl)-c1csc(c1)C(=O)NC1CCOCC1 InChI=1S/C23H20ClFN4O2S/c24-17-3-1-2-4-19(17)28-20-9-14-12-26-29(21(14)11-18(20)25)16-10-22(32-13-16)23(30)27-15-5-7-31-8-6-15/h1-4,9-13,15,28H,5-8H2,(H,27,30) MLEMAYBWCXSCBM-UHFFFAOYSA-N 50577624 CHEMBL4867426 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577624&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155319 471053747 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429781 [2H]C([2H])([2H])N1CC[C@@H](C1)NC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)c(F)cc12 InChI=1S/C23H21ClFN5OS/c1-29-7-6-15(12-29)27-23(31)22-9-16(13-32-22)30-21-10-18(25)20(8-14(21)11-26-30)28-19-5-3-2-4-17(19)24/h2-5,8-11,13,15,28H,6-7,12H2,1H3,(H,27,31)/t15-/m0/s1/i1D3 VYNVVWLFRMWZRV-VSLDJYOXSA-N 50577625 CHEMBL4847175 Mitogen-activated protein kinase 10 Homo sapiens 5.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577625&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155299 471053748 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429782 CC(=O)N1CC[C@@H](C1)NC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)c(F)cc12 InChI=1S/C24H21ClFN5O2S/c1-14(32)30-7-6-16(12-30)28-24(33)23-9-17(13-34-23)31-22-10-19(26)21(8-15(22)11-27-31)29-20-5-3-2-4-18(20)25/h2-5,8-11,13,16,29H,6-7,12H2,1H3,(H,28,33)/t16-/m0/s1 CNOBUOFKVJJORP-INIZCTEOSA-N 50577626 CHEMBL4862656 Mitogen-activated protein kinase 10 Homo sapiens 4.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155614 471053749 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429783 CC(C)NC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)c(F)cc12 InChI=1S/C21H18ClFN4OS/c1-12(2)25-21(28)20-8-14(11-29-20)27-19-9-16(23)18(7-13(19)10-24-27)26-17-6-4-3-5-15(17)22/h3-12,26H,1-2H3,(H,25,28) HCSPNAHQHBSATE-UHFFFAOYSA-N 50577627 CHEMBL4865870 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155358 471053750 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429784 FC(F)CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)c(F)cc12 InChI=1S/C20H14ClF3N4OS/c21-13-3-1-2-4-15(13)27-16-5-11-8-26-28(17(11)7-14(16)22)12-6-18(30-10-12)20(29)25-9-19(23)24/h1-8,10,19,27H,9H2,(H,25,29) JLOWBCPGKBVSGH-UHFFFAOYSA-N 50577628 CHEMBL4879188 Mitogen-activated protein kinase 10 Homo sapiens 4.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577628&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156165169 471053751 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429785 COCCNC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)c(F)cc12 InChI=1S/C21H18ClFN4O2S/c1-29-7-6-24-21(28)20-9-14(12-30-20)27-19-10-16(23)18(8-13(19)11-25-27)26-17-5-3-2-4-15(17)22/h2-5,8-12,26H,6-7H2,1H3,(H,24,28) XTFFMIPOKWLBRH-UHFFFAOYSA-N 50577629 CHEMBL4876387 Mitogen-activated protein kinase 10 Homo sapiens 3.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577629&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155382 471053752 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429786 Fc1cc2n(ncc2cc1Nc1ccccc1Cl)-c1csc(c1)C(=O)NC1CC1 InChI=1S/C21H16ClFN4OS/c22-15-3-1-2-4-17(15)26-18-7-12-10-24-27(19(12)9-16(18)23)14-8-20(29-11-14)21(28)25-13-5-6-13/h1-4,7-11,13,26H,5-6H2,(H,25,28) ZDMNBFRGLJDTJG-UHFFFAOYSA-N 50577630 CHEMBL4861739 Mitogen-activated protein kinase 10 Homo sapiens 1.000000 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577630&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155305 471053753 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429787 CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)c(F)cc12 InChI=1S/C19H14ClFN4OS/c1-22-19(26)18-7-12(10-27-18)25-17-8-14(21)16(6-11(17)9-23-25)24-15-5-3-2-4-13(15)20/h2-10,24H,1H3,(H,22,26) XMMMCYBZGARUKP-UHFFFAOYSA-N 50577631 CHEMBL4874134 Mitogen-activated protein kinase 10 Homo sapiens 5.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577631&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155311 471053754 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429788 [2H]C([2H])([2H])N1CC[C@@H](C1)NC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)ccc12 InChI=1S/C23H22ClN5OS/c1-28-9-8-17(13-28)27-23(30)22-11-18(14-31-22)29-21-7-6-16(10-15(21)12-25-29)26-20-5-3-2-4-19(20)24/h2-7,10-12,14,17,26H,8-9,13H2,1H3,(H,27,30)/t17-/m0/s1/i1D3 OTFWOWGRYVMGKI-DBHFXHLNSA-N 50577632 CHEMBL4875508 Mitogen-activated protein kinase 10 Homo sapiens 1.000000 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155627 471053755 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429789 CC(C)N1CC[C@H](C1)NC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)ccc12 InChI=1S/C25H26ClN5OS/c1-16(2)30-10-9-19(14-30)29-25(32)24-12-20(15-33-24)31-23-8-7-18(11-17(23)13-27-31)28-22-6-4-3-5-21(22)26/h3-8,11-13,15-16,19,28H,9-10,14H2,1-2H3,(H,29,32)/t19-/m1/s1 WXTIZLXTOMJFTP-LJQANCHMSA-N 50577633 CHEMBL4869300 Mitogen-activated protein kinase 10 Homo sapiens 31 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155383 471053756 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429790 CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)c(OC)cc12 InChI=1S/C20H17ClN4O2S/c1-22-20(26)19-8-13(11-28-19)25-17-9-18(27-2)16(7-12(17)10-23-25)24-15-6-4-3-5-14(15)21/h3-11,24H,1-2H3,(H,22,26) TYFREKXWJOQZSG-UHFFFAOYSA-N 50577634 CHEMBL4853326 Mitogen-activated protein kinase 10 Homo sapiens 20 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577634&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155542 471053757 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429791 CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3c(F)cccc3Cl)c(F)cc12 InChI=1S/C19H13ClF2N4OS/c1-23-19(27)17-6-11(9-28-17)26-16-7-14(22)15(5-10(16)8-24-26)25-18-12(20)3-2-4-13(18)21/h2-9,25H,1H3,(H,23,27) QJBMKTXSJOENPI-UHFFFAOYSA-N 50577635 CHEMBL4874573 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577635&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155399 471053758 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429792 CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3c(F)cccc3OC)c(F)cc12 InChI=1S/C20H16F2N4O2S/c1-23-20(27)18-7-12(10-29-18)26-16-8-14(22)15(6-11(16)9-24-26)25-19-13(21)4-3-5-17(19)28-2/h3-10,25H,1-2H3,(H,23,27) DSFZMDKHAONJTA-UHFFFAOYSA-N 50577636 CHEMBL4875476 Mitogen-activated protein kinase 10 Homo sapiens 5.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577636&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155324 471053759 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429793 CNC(=O)c1cc(cs1)-n1ncc2cc(Oc3ccccc3Cl)ccc12 InChI=1S/C19H14ClN3O2S/c1-21-19(24)18-9-13(11-26-18)23-16-7-6-14(8-12(16)10-22-23)25-17-5-3-2-4-15(17)20/h2-11H,1H3,(H,21,24) JAPSMYSZFOTZPZ-UHFFFAOYSA-N 50577637 CHEMBL4864514 Mitogen-activated protein kinase 10 Homo sapiens 30 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577637&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155391 471053760 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429794 CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3ccccc3Cl)cnc12 InChI=1S/C18H14ClN5OS/c1-20-18(25)16-7-13(10-26-16)24-17-11(8-22-24)6-12(9-21-17)23-15-5-3-2-4-14(15)19/h2-10,23H,1H3,(H,20,25) TUFAYPAXFHVGTH-UHFFFAOYSA-N 50577638 CHEMBL4851793 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577638&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155417 471053761 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429795 CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3c(F)cccc3Cl)ncc12 InChI=1S/C18H13ClFN5OS/c1-21-18(26)15-6-11(9-27-15)25-14-8-22-16(5-10(14)7-23-25)24-17-12(19)3-2-4-13(17)20/h2-9H,1H3,(H,21,26)(H,22,24) YFZJFPUOKUFWQU-UHFFFAOYSA-N 50577639 CHEMBL4877727 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577639&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156165095 471053762 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429796 CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3c(F)cccc3Cl)cnc12 InChI=1S/C18H13ClFN5OS/c1-21-18(26)15-6-12(9-27-15)25-17-10(7-23-25)5-11(8-22-17)24-16-13(19)3-2-4-14(16)20/h2-9,24H,1H3,(H,21,26) JOWZBTCWJHFAQE-UHFFFAOYSA-N 50577640 CHEMBL4857979 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577640&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155797 471053763 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429797 CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3c(F)cccc3Cl)c(C)nc12 InChI=1S/C19H15ClFN5OS/c1-10-15(25-17-13(20)4-3-5-14(17)21)6-11-8-23-26(18(11)24-10)12-7-16(28-9-12)19(27)22-2/h3-9,25H,1-2H3,(H,22,27) BQHWGFRFUSNBMX-UHFFFAOYSA-N 50577641 CHEMBL4859957 Mitogen-activated protein kinase 10 Homo sapiens 12 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577641&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155385 471053764 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429798 CNC(=O)c1cc(cs1)-n1ncc2cc(Nc3cccc(OC)c3Cl)c(C)nc12 InChI=1S/C20H18ClN5O2S/c1-11-15(25-14-5-4-6-16(28-3)18(14)21)7-12-9-23-26(19(12)24-11)13-8-17(29-10-13)20(27)22-2/h4-10,25H,1-3H3,(H,22,27) QFMZNDDXNKIBNE-UHFFFAOYSA-N 50577642 CHEMBL4853306 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577642&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155336 471053765 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429799 Cc1nc2n(ncc2cc1Nc1cccc(F)c1Cl)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C21H17ClFN5O2S/c1-11-17(27-16-4-2-3-15(23)19(16)22)5-12-7-24-28(20(12)25-11)14-6-18(31-10-14)21(29)26-13-8-30-9-13/h2-7,10,13,27H,8-9H2,1H3,(H,26,29) OPNIKHXLTLSOEA-UHFFFAOYSA-N 50577643 CHEMBL4876785 Mitogen-activated protein kinase 10 Homo sapiens 169 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577643&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155691 471053766 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429800 Cc1nc2n(ncc2cc1Nc1ccc(F)cc1Cl)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C21H17ClFN5O2S/c1-11-18(27-17-3-2-13(23)5-16(17)22)4-12-7-24-28(20(12)25-11)15-6-19(31-10-15)21(29)26-14-8-30-9-14/h2-7,10,14,27H,8-9H2,1H3,(H,26,29) WEKXWKLEXYHQPV-UHFFFAOYSA-N 50577644 CHEMBL4854405 Mitogen-activated protein kinase 10 Homo sapiens 79 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577644&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155625 471053767 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429801 Cc1nc2n(ncc2cc1Nc1cc(F)ccc1Cl)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C21H17ClFN5O2S/c1-11-17(27-18-5-13(23)2-3-16(18)22)4-12-7-24-28(20(12)25-11)15-6-19(31-10-15)21(29)26-14-8-30-9-14/h2-7,10,14,27H,8-9H2,1H3,(H,26,29) YUDWKEAEZWLVGN-UHFFFAOYSA-N 50577645 CHEMBL4863524 Mitogen-activated protein kinase 10 Homo sapiens 1070 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577645&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156155393 471053768 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51429802 Cc1nc2n(ncc2cc1Nc1c(F)cccc1Cl)-c1csc(c1)C(=O)NC1COC1 InChI=1S/C21H17ClFN5O2S/c1-11-17(27-19-15(22)3-2-4-16(19)23)5-12-7-24-28(20(12)25-11)14-6-18(31-10-14)21(29)26-13-8-30-9-13/h2-7,10,13,27H,8-9H2,1H3,(H,26,29) KDMADGZAPDHVHE-UHFFFAOYSA-N 50577646 CHEMBL4845770 Mitogen-activated protein kinase 10 Homo sapiens 5.0 ChEMBL 10.1021/acsmedchemlett.1c00334 10.7270/Q2445RBQ 34676036 Feng, Y; Park, H; Ryu, JC; Yoon, SO Reaction Biology Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577646&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 86C 7S1N 156155310 471053769 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51448354 CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]c(F)c(-c4cn(CCCC1=O)nc4C(F)(F)F)c3c2 50585046 CHEMBL5086263 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acsmedchemlett.1c00630 10.7270/Q2183BDB 35450378 Powell, CE; Hatcher, JM; Jiang, J; Vatsan, PS; Che, J; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585046&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 166633521 476021133 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488650 CC(C)CN(CC(=O)NCCCCCCNC(=O)c1ccc(cc1)-c1n[nH]c2ccccc12)C(=O)CNC(=O)C1COc2ccccc2C1 50599927 CHEMBL5193515 Mitogen-activated protein kinase 10 Homo sapiens 99 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599927&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168286620 482610779 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488651 Clc1ccc(cc1Cl)-c1cc(CC#N)nn1-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C23H21Cl2N7O/c24-18-4-3-15(11-19(18)25)20-12-16(5-8-26)30-32(20)21-6-9-27-23(29-21)28-17-7-10-31(13-17)22(33)14-1-2-14/h3-4,6,9,11-12,14,17H,1-2,5,7,10,13H2,(H,27,28,29)/t17-/m1/s1 IHKVJMUPCKDKOP-QGZVFWFLSA-N 50599928 CHEMBL5190624 Mitogen-activated protein kinase 10 Homo sapiens 227 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599928&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168280371 482610780 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488652 CSc1nc(C)c([nH]1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C20H23N5OS/c1-14-19(24-20(22-14)27-2)15-7-8-21-18(13-15)23-16-3-5-17(6-4-16)25-9-11-26-12-10-25/h3-8,13H,9-12H2,1-2H3,(H,21,23)(H,22,24) IATSSYNKRCFJAY-UHFFFAOYSA-N 50599929 CHEMBL5194871 Mitogen-activated protein kinase 10 Homo sapiens 184 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599929&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B9K 134693850 482610781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488653 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488654 Clc1ccc2[nH]c(=O)c(SCC(=O)NC3CCCC3)c(-c3ccccc3)c2c1 InChI=1S/C22H21ClN2O2S/c23-15-10-11-18-17(12-15)20(14-6-2-1-3-7-14)21(22(27)25-18)28-13-19(26)24-16-8-4-5-9-16/h1-3,6-7,10-12,16H,4-5,8-9,13H2,(H,24,26)(H,25,27) VRXUFERDKQBCLY-UHFFFAOYSA-N 50599930 CHEMBL5183304 Mitogen-activated protein kinase 10 Homo sapiens 58 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599930&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1214278 482610782 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488655 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nccc(n2)-c2cccnc2)c1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-22-12-10-20(11-13-22)27(37)32-23-7-3-8-24(18-23)33-28-30-16-14-25(34-28)21-6-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ VZEONOGFXYTZGT-WEVVVXLNSA-N 86627 JNK-IN-2 Mitogen-activated protein kinase 10 Homo sapiens 709 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340680 136352676 ZINC89464829 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488656 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ RADRIIWGHYFWPP-WEVVVXLNSA-N 86632 JNK-IN-7 Mitogen-activated protein kinase 10 Homo sapiens 0.750000 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340685 136352681 ZINC87723492 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488657 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1 InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ GJFCSAPFHAXMSF-UXBLZVDNSA-N 86633 JNK-IN-8 Mitogen-activated protein kinase 10 Homo sapiens 0.980000 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340686 136352682 ZINC89464842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488658 CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(NC(=O)C=C)c4)cc3)c2)n1C)-c1ccc(F)cc1 InChI=1S/C32H27FN6O2S/c1-4-28(40)36-26-7-5-6-22(18-26)31(41)37-25-14-12-24(13-15-25)35-27-19-21(16-17-34-27)30-29(38-32(42-3)39(30)2)20-8-10-23(33)11-9-20/h4-19H,1H2,2-3H3,(H,34,35)(H,36,40)(H,37,41) SHSDJTLZMWMUMU-UHFFFAOYSA-N 50234890 CHEMBL4077018 Mitogen-activated protein kinase 10 Homo sapiens 0.300000 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234890&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137650943 384584942 CHEMBL4077018 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488659 CSc1nc(C)c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(NC(=O)C=C)c4)cc3)c2)n1C InChI=1S/C27H26N6O2S/c1-5-24(34)31-22-8-6-7-19(15-22)26(35)32-21-11-9-20(10-12-21)30-23-16-18(13-14-28-23)25-17(2)29-27(36-4)33(25)3/h5-16H,1H2,2-4H3,(H,28,30)(H,31,34)(H,32,35) DPQFXORGMUHXNL-UHFFFAOYSA-N 50599931 CHEMBL5185450 Mitogen-activated protein kinase 10 Homo sapiens 2000 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599931&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168282627 482610783 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488660 O=C(Cc1cccc2cnccc12)Nc1scnc1-c1cscn1 InChI=1S/C17H12N4OS2/c22-15(6-11-2-1-3-12-7-18-5-4-13(11)12)21-17-16(20-10-24-17)14-8-23-9-19-14/h1-5,7-10H,6H2,(H,21,22) BGGSTZPBQKGLOJ-UHFFFAOYSA-N 50332091 CHEMBL1288160::N-(4,4'-bithiazol-5-yl)-2-(isoquinolin-5-yl)acetamide::US9796706, Compound 87 Mitogen-activated protein kinase 10 Homo sapiens 77 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332091&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 49839481 123111206 CHEMBL1288160 ZINC64573024 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488661 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1 InChI=1S/C29H29N7O2/c1-20-8-11-24(18-26(20)35-29-31-16-14-25(34-29)22-6-4-15-30-19-22)33-28(38)21-9-12-23(13-10-21)32-27(37)7-5-17-36(2)3/h4-16,18-19H,17H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b7-5+ YFRXAAWSVLQGDR-FNORWQNLSA-N 86626 JNK-IN-1 Mitogen-activated protein kinase 10 Homo sapiens 7750 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 25123232 136352675 ZINC87723487 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488662 NC(=O)N1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C24H24Cl2N8O2/c25-16-4-3-14(9-17(16)26)21-30-18-11-33(23(27)36)12-19(18)34(21)20-5-7-28-24(31-20)29-15-6-8-32(10-15)22(35)13-1-2-13/h3-5,7,9,13,15H,1-2,6,8,10-12H2,(H2,27,36)(H,28,29,31)/t15-/m0/s1 LGICVDGDWJJCIH-HNNXBMFYSA-N 50599932 CHEMBL5194407 Mitogen-activated protein kinase 10 Homo sapiens 2.9 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599932&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 156840408 482610784 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488674 Oc1nnc(Sc2ncc(s2)[N+]([O-])=O)n1-c1ccc2OCCOc2c1 InChI=1S/C13H9N5O5S2/c19-11-15-16-12(25-13-14-6-10(24-13)18(20)21)17(11)7-1-2-8-9(5-7)23-4-3-22-8/h1-2,5-6H,3-4H2,(H,15,19) QFRLDZGQEZCCJZ-UHFFFAOYSA-N 50526695 BI-78D3::CHEMBL508280 Mitogen-activated protein kinase 10 Homo sapiens 32 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526695&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2747117 440735277 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488675 Oc1nnc(Sc2ncc(s2)[N+]([O-])=O)n1-c1ccc2OCCOc2c1 InChI=1S/C13H9N5O5S2/c19-11-15-16-12(25-13-14-6-10(24-13)18(20)21)17(11)7-1-2-8-9(5-7)23-4-3-22-8/h1-2,5-6H,3-4H2,(H,15,19) QFRLDZGQEZCCJZ-UHFFFAOYSA-N 50526695 BI-78D3::CHEMBL508280 Mitogen-activated protein kinase 10 Homo sapiens 507 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526695&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 2747117 440735277 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488679 CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O InChI=1S/C110H198N46O25/c1-58(2)53-75(150-99(177)78(56-81(115)160)152-97(175)76(54-59(3)4)153-101(179)83(60(5)157)155-102(180)84(61(6)158)154-100(178)79-38-24-52-156(79)103(181)74(37-23-51-137-110(128)129)149-94(172)67(29-12-15-43-113)140-86(164)63-30-16-44-130-63)96(174)151-77(55-62-25-8-7-9-26-62)98(176)147-72(36-22-50-136-109(126)127)92(170)144-69(33-19-47-133-106(120)121)90(168)145-71(35-21-49-135-108(124)125)93(171)148-73(39-40-80(114)159)95(173)146-70(34-20-48-134-107(122)123)91(169)143-68(32-18-46-132-105(118)119)89(167)142-66(28-11-14-42-112)88(166)141-65(27-10-13-41-111)87(165)139-64(31-17-45-131-104(116)117)85(163)138-57-82(161)162/h7-9,25-26,58-61,63-79,83-84,130,157-158H,10-24,27-57,111-113H2,1-6H3,(H2,114,159)(H2,115,160)(H,138,163)(H,139,165)(H,140,164)(H,141,166)(H,142,167)(H,143,169)(H,144,170)(H,145,168)(H,146,173)(H,147,176)(H,148,171)(H,149,172)(H,150,177)(H,151,174)(H,152,175)(H,153,179)(H,154,178)(H,155,180)(H,161,162)(H4,116,117,131)(H4,118,119,132)(H4,120,121,133)(H4,122,123,134)(H4,124,125,135)(H4,126,127,136)(H4,128,129,137)/t60-,61-,63+,64+,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,79+,83+,84+/m1/s1 HBNIKGLJQLAUBP-BVZDOOJKSA-N 50599933 CHEMBL5179856 Mitogen-activated protein kinase 10 Homo sapiens 1200 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599933&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168272302 482610785 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488680 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCCCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O InChI=1S/C112H200N46O25S/c1-11-59(6)82(155-88(166)65-30-18-42-130-65)100(178)154-78(56-184)98(176)148-72(37-25-49-138-111(126)127)103(181)158-51-27-39-79(158)99(177)156-84(63(10)160)102(180)157-83(62(9)159)101(179)153-75(53-58(4)5)96(174)152-77(55-80(113)161)97(175)150-74(52-57(2)3)95(173)151-76(54-64-28-14-12-15-29-64)87(165)131-41-17-13-16-40-81(162)142-66(31-19-43-132-105(114)115)91(169)145-67(32-20-44-133-106(116)117)89(167)140-60(7)85(163)143-69(34-22-46-135-108(120)121)92(170)146-68(33-21-45-134-107(118)119)90(168)141-61(8)86(164)144-70(35-23-47-136-109(122)123)93(171)147-71(36-24-48-137-110(124)125)94(172)149-73(104(182)183)38-26-50-139-112(128)129/h12,14-15,28-29,57-63,65-79,82-84,130,159-160,184H,11,13,16-27,30-56H2,1-10H3,(H2,113,161)(H,131,165)(H,140,167)(H,141,168)(H,142,162)(H,143,163)(H,144,164)(H,145,169)(H,146,170)(H,147,171)(H,148,176)(H,149,172)(H,150,175)(H,151,173)(H,152,174)(H,153,179)(H,154,178)(H,155,166)(H,156,177)(H,157,180)(H,182,183)(H4,114,115,132)(H4,116,117,133)(H4,118,119,134)(H4,120,121,135)(H4,122,123,136)(H4,124,125,137)(H4,126,127,138)(H4,128,129,139)/t59-,60-,61-,62+,63+,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,82-,83-,84-/m0/s1 YTUBAXJNDJURIY-DEGFCSBOSA-N 50599934 CHEMBL5170124 Mitogen-activated protein kinase 10 Homo sapiens 1200 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599934&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168269542 482610786 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51466573 O=C(\C=C1/Nc2ccccc2NC1=O)c1cccc2ccccc12 InChI=1S/C20H14N2O2/c23-19(15-9-5-7-13-6-1-2-8-14(13)15)12-18-20(24)22-17-11-4-3-10-16(17)21-18/h1-12,21H,(H,22,24)/b18-12- ZMFVICCTJZQVDM-PDGQHHTCSA-N 50515263 CHEMBL4531109 Mitogen-activated protein kinase 10 Homo sapiens 250 ChEMBL 10.7270/Q2XW4PS2 34998058 Jiang, X; Wu, K; Bai, R; Zhang, P; Zhang, Y Central South University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515263&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135883136 440723845 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51466574 O=C(\C=C1/Nc2cc(ccc2NC1=O)C#N)c1cccc2ccccc12 InChI=1S/C21H13N3O2/c22-12-13-8-9-17-18(10-13)23-19(21(26)24-17)11-20(25)16-7-3-5-14-4-1-2-6-15(14)16/h1-11,23H,(H,24,26)/b19-11- LLVGRQUDHSCNNV-ODLFYWEKSA-N 50565131 CHEMBL4795574 Mitogen-activated protein kinase 10 Homo sapiens 190 ChEMBL 10.7270/Q2XW4PS2 34998058 Jiang, X; Wu, K; Bai, R; Zhang, P; Zhang, Y Central South University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50565131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50565131&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 162674227 461685469 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51464616 CNC(=O)[C@]1(C)CC[C@H](C1)Nc1ncc2c(Br)nn(-c3ccc(cc3)-c3nnc(C)s3)c2n1 InChI=1S/C22H23BrN8OS/c1-12-28-29-19(33-12)13-4-6-15(7-5-13)31-18-16(17(23)30-31)11-25-21(27-18)26-14-8-9-22(2,10-14)20(32)24-3/h4-7,11,14H,8-10H2,1-3H3,(H,24,32)(H,25,26,27)/t14-,22-/m1/s1 ASGMFNBUXDJWJJ-JLCFBVMHSA-N 50591066 CHEMBL5190023 Mitogen-activated protein kinase 10 Homo sapiens 101 ChEMBL 10.7270/Q27H1PJS 36127295 Jackson, JJ; Shibuya, GM; Ravishankar, B; Adusumilli, L; Bradford, D; Brockstedt, DG; Bucher, C; Bui, M; Cho, C; Colas, C; Cutler, G; Dukes, A; Han, X; Hu, DX; Jacobson, S; Kassner, PD; Katibah, GE; Ko, MYM; Kolhatkar, U; Leger, PR; Ma, A; Marshall, L; Maung, J; Ng, AA; Okano, A; Pookot, D; Poon, D; Ramana, C; Reilly, MK; Robles, O; Schwarz, JB; Shakhmin, AA; Shunatona, HP; Sreenivasan, R; Tivitmahaisoon, P; Xu, M; Zaw, T; Wustrow, DJ; Zibinsky, M RAPT Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591066&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 147002269 482601918 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51488639 Cc1ccc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cn1 InChI=1S/C23H19ClN6O2/c1-15-9-10-17(12-25-15)27-22(31)16-5-4-6-19(11-16)30-14-18(13-26-30)28-23(32)29-21-8-3-2-7-20(21)24/h2-14H,1H3,(H,27,31)(H2,28,29,32) QAPNZNFLFCTLFN-UHFFFAOYSA-N 50032816 CHEMBL3355146 Mitogen-activated protein kinase 10 Homo sapiens 55 ChEMBL 10.7270/Q2CV4NSB 35200035 Zhu, Y; Shuai, W; Zhao, M; Pan, X; Pei, J; Wu, Y; Bu, F; Wang, A; Ouyang, L; Wang, G National Clinical Research Center for Geriatrics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032816&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 118143962 312528603 CHEMBL3355146 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51478469 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.7270/Q20Z779V 33970631 García-Cárceles, J; Caballero, E; Gil, C; Martínez, A Centro de Investigaciones Biol�gicas Margarita Salas (CSIC) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468140 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 91 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468141 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2ccc(F)cc2)c1)-c1ccccc1 InChI=1S/C29H25FN6O2/c30-22-9-11-23(12-10-22)34-29(38)33-16-15-32-27-18-20(13-14-31-27)26-19-36(24-6-2-1-3-7-24)35-28(26)21-5-4-8-25(37)17-21/h1-14,17-19,37H,15-16H2,(H,31,32)(H2,33,34,38) DOPVRNNEAOBWGJ-UHFFFAOYSA-N 50592447 CHEMBL5196004 Mitogen-activated protein kinase 10 Homo sapiens 190 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592447&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168287659 482603299 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468142 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2ccc(Cl)c(Cl)c2)c1)-c1ccccc1 InChI=1S/C29H24Cl2N6O2/c30-25-10-9-21(17-26(25)31)35-29(39)34-14-13-33-27-16-19(11-12-32-27)24-18-37(22-6-2-1-3-7-22)36-28(24)20-5-4-8-23(38)15-20/h1-12,15-18,38H,13-14H2,(H,32,33)(H2,34,35,39) HZYXNQSQNJIKGP-UHFFFAOYSA-N 50592448 CHEMBL5183673 Mitogen-activated protein kinase 10 Homo sapiens 526 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592448&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168282124 482603300 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468143 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2cccc(c2)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C30H25F3N6O2/c31-30(32,33)22-7-5-8-23(18-22)37-29(41)36-15-14-35-27-17-20(12-13-34-27)26-19-39(24-9-2-1-3-10-24)38-28(26)21-6-4-11-25(40)16-21/h1-13,16-19,40H,14-15H2,(H,34,35)(H2,36,37,41) HGCVWICUBZDORS-UHFFFAOYSA-N 50592449 CHEMBL5201911 Mitogen-activated protein kinase 10 Homo sapiens 99 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592449&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168291900 482603301 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468144 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C30H24ClF3N6O2/c31-26-10-9-21(17-25(26)30(32,33)34)38-29(42)37-14-13-36-27-16-19(11-12-35-27)24-18-40(22-6-2-1-3-7-22)39-28(24)20-5-4-8-23(41)15-20/h1-12,15-18,41H,13-14H2,(H,35,36)(H2,37,38,42) HLWFBXQPNMBWJJ-UHFFFAOYSA-N 50592450 CHEMBL5190930 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592450&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168286888 482603302 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468145 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C31H24F6N6O2/c32-30(33,34)21-15-22(31(35,36)37)17-23(16-21)41-29(45)40-12-11-39-27-14-19(9-10-38-27)26-18-43(24-6-2-1-3-7-24)42-28(26)20-5-4-8-25(44)13-20/h1-10,13-18,44H,11-12H2,(H,38,39)(H2,40,41,45) XYJHOOBOWOGYAJ-UHFFFAOYSA-N 50592451 CHEMBL5190777 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592451&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168280450 482603303 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468146 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2ccc(F)cc2)c1)-c1ccccc1 InChI=1S/C30H27FN6O2/c31-23-10-12-24(13-11-23)35-30(39)34-16-5-15-32-28-19-21(14-17-33-28)27-20-37(25-7-2-1-3-8-25)36-29(27)22-6-4-9-26(38)18-22/h1-4,6-14,17-20,38H,5,15-16H2,(H,32,33)(H2,34,35,39) BCNMJLRKWYKBBZ-UHFFFAOYSA-N 50592452 CHEMBL5191468 Mitogen-activated protein kinase 10 Homo sapiens 97 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592452&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168287868 482603304 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468147 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2ccc(Cl)c(Cl)c2)c1)-c1ccccc1 InChI=1S/C30H26Cl2N6O2/c31-26-11-10-22(18-27(26)32)36-30(40)35-14-5-13-33-28-17-20(12-15-34-28)25-19-38(23-7-2-1-3-8-23)37-29(25)21-6-4-9-24(39)16-21/h1-4,6-12,15-19,39H,5,13-14H2,(H,33,34)(H2,35,36,40) OHFPWTGFGYZHEC-UHFFFAOYSA-N 50592453 CHEMBL5177988 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592453&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168277407 482603305 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468148 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2cccc(c2)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C31H27F3N6O2/c32-31(33,34)23-8-5-9-24(19-23)38-30(42)37-15-6-14-35-28-18-21(13-16-36-28)27-20-40(25-10-2-1-3-11-25)39-29(27)22-7-4-12-26(41)17-22/h1-5,7-13,16-20,41H,6,14-15H2,(H,35,36)(H2,37,38,42) KEZRNSQBXOWDMI-UHFFFAOYSA-N 50592454 CHEMBL5205920 Mitogen-activated protein kinase 10 Homo sapiens 474 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592454&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168294873 482603306 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468149 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C31H26ClF3N6O2/c32-27-11-10-22(18-26(27)31(33,34)35)39-30(43)38-14-5-13-36-28-17-20(12-15-37-28)25-19-41(23-7-2-1-3-8-23)40-29(25)21-6-4-9-24(42)16-21/h1-4,6-12,15-19,42H,5,13-14H2,(H,36,37)(H2,38,39,43) RNPFZSNLWOSMIW-UHFFFAOYSA-N 50592455 CHEMBL5179126 Mitogen-activated protein kinase 10 Homo sapiens 614 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592455&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168272253 482603307 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468150 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C32H26F6N6O2/c33-31(34,35)22-16-23(32(36,37)38)18-24(17-22)42-30(46)41-12-5-11-39-28-15-20(10-13-40-28)27-19-44(25-7-2-1-3-8-25)43-29(27)21-6-4-9-26(45)14-21/h1-4,6-10,13-19,45H,5,11-12H2,(H,39,40)(H2,41,42,46) XNEURSCKWYCFQX-UHFFFAOYSA-N 50592456 CHEMBL5206891 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592456&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168295429 482603308 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468151 COc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2ccc(F)cc2)c1)-c1ccccc1 InChI=1S/C31H29FN6O2/c1-40-27-10-5-7-23(19-27)30-28(21-38(37-30)26-8-3-2-4-9-26)22-15-18-34-29(20-22)33-16-6-17-35-31(39)36-25-13-11-24(32)12-14-25/h2-5,7-15,18-21H,6,16-17H2,1H3,(H,33,34)(H2,35,36,39) BBDDFAGBJKUSTL-UHFFFAOYSA-N 50592457 CHEMBL5182819 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592457&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168282482 482603309 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468152 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccccc1)-c1ccccc1 InChI=1S/C32H30N6O2/c1-40-28-14-8-9-25(21-28)31-29(23-38(35-31)27-12-6-3-7-13-27)24-15-16-33-30(22-24)36-17-19-37(20-18-36)32(39)34-26-10-4-2-5-11-26/h2-16,21-23H,17-20H2,1H3,(H,34,39) GKHDVYYMZFVABP-UHFFFAOYSA-N 50592458 CHEMBL5173811 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592458&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168276456 482603310 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468153 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(F)cc1)-c1ccccc1 InChI=1S/C32H29FN6O2/c1-41-28-9-5-6-24(20-28)31-29(22-39(36-31)27-7-3-2-4-8-27)23-14-15-34-30(21-23)37-16-18-38(19-17-37)32(40)35-26-12-10-25(33)11-13-26/h2-15,20-22H,16-19H2,1H3,(H,35,40) LUYQCPFUZIYKJS-UHFFFAOYSA-N 50592459 CHEMBL5190656 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592459&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168281964 482603311 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468154 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(Cl)c1)-c1ccccc1 InChI=1S/C32H28Cl2N6O2/c1-42-26-9-5-6-23(18-26)31-27(21-40(37-31)25-7-3-2-4-8-25)22-12-13-35-30(19-22)38-14-16-39(17-15-38)32(41)36-24-10-11-28(33)29(34)20-24/h2-13,18-21H,14-17H2,1H3,(H,36,41) MULVGZBQVRJAIQ-UHFFFAOYSA-N 50592460 CHEMBL5206209 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592460&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168296987 482603312 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468155 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cccc(c1)C(F)(F)F)-c1ccccc1 InChI=1S/C33H29F3N6O2/c1-44-28-12-5-7-24(19-28)31-29(22-42(39-31)27-10-3-2-4-11-27)23-13-14-37-30(20-23)40-15-17-41(18-16-40)32(43)38-26-9-6-8-25(21-26)33(34,35)36/h2-14,19-22H,15-18H2,1H3,(H,38,43) NWCQTCRZIKMCPD-UHFFFAOYSA-N 50592461 CHEMBL5180621 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592461&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168275936 482603313 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468156 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)-c1ccccc1 InChI=1S/C33H28ClF3N6O2/c1-45-26-9-5-6-23(18-26)31-27(21-43(40-31)25-7-3-2-4-8-25)22-12-13-38-30(19-22)41-14-16-42(17-15-41)32(44)39-24-10-11-29(34)28(20-24)33(35,36)37/h2-13,18-21H,14-17H2,1H3,(H,39,44) XKWSFNDEMWBYOK-UHFFFAOYSA-N 50592462 CHEMBL5176396 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592462&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168278134 482603314 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468157 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)-c1ccccc1 InChI=1S/C34H28F6N6O2/c1-48-28-9-5-6-23(16-28)31-29(21-46(43-31)27-7-3-2-4-8-27)22-10-11-41-30(17-22)44-12-14-45(15-13-44)32(47)42-26-19-24(33(35,36)37)18-25(20-26)34(38,39)40/h2-11,16-21H,12-15H2,1H3,(H,42,47) SETUZDZATNQNPE-UHFFFAOYSA-N 50592463 CHEMBL5175285 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592463&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168275733 482603315 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468158 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccccc1)-c1ccccc1 InChI=1S/C31H28N6O2/c38-27-13-7-8-24(20-27)30-28(22-37(34-30)26-11-5-2-6-12-26)23-14-15-32-29(21-23)35-16-18-36(19-17-35)31(39)33-25-9-3-1-4-10-25/h1-15,20-22,38H,16-19H2,(H,33,39) IIFODDWMFNMVPV-UHFFFAOYSA-N 50592464 CHEMBL5199545 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592464&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168290953 482603316 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468159 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(F)cc1)-c1ccccc1 InChI=1S/C31H27FN6O2/c32-24-9-11-25(12-10-24)34-31(40)37-17-15-36(16-18-37)29-20-22(13-14-33-29)28-21-38(26-6-2-1-3-7-26)35-30(28)23-5-4-8-27(39)19-23/h1-14,19-21,39H,15-18H2,(H,34,40) DYVICTWHFCUYNP-UHFFFAOYSA-N 50592465 CHEMBL5171564 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592465&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168269200 482603317 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468160 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(Cl)c1)-c1ccccc1 InChI=1S/C31H26Cl2N6O2/c32-27-10-9-23(19-28(27)33)35-31(41)38-15-13-37(14-16-38)29-18-21(11-12-34-29)26-20-39(24-6-2-1-3-7-24)36-30(26)22-5-4-8-25(40)17-22/h1-12,17-20,40H,13-16H2,(H,35,41) WLWYMADLURCSIU-UHFFFAOYSA-N 50592466 CHEMBL5197538 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592466&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168284474 482603318 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468161 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cccc(c1)C(F)(F)F)-c1ccccc1 InChI=1S/C32H27F3N6O2/c33-32(34,35)24-7-5-8-25(20-24)37-31(43)40-16-14-39(15-17-40)29-19-22(12-13-36-29)28-21-41(26-9-2-1-3-10-26)38-30(28)23-6-4-11-27(42)18-23/h1-13,18-21,42H,14-17H2,(H,37,43) PYTYPQIAQRSIDG-UHFFFAOYSA-N 50592467 CHEMBL5174880 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592467&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168275728 482603319 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468162 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)-c1ccccc1 InChI=1S/C32H26ClF3N6O2/c33-28-10-9-23(19-27(28)32(34,35)36)38-31(44)41-15-13-40(14-16-41)29-18-21(11-12-37-29)26-20-42(24-6-2-1-3-7-24)39-30(26)22-5-4-8-25(43)17-22/h1-12,17-20,43H,13-16H2,(H,38,44) XJAJDOWMQVDEOT-UHFFFAOYSA-N 50592468 CHEMBL5179338 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592468&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168275513 482603320 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468163 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)-c1ccccc1 InChI=1S/C33H26F6N6O2/c34-32(35,36)23-17-24(33(37,38)39)19-25(18-23)41-31(47)44-13-11-43(12-14-44)29-16-21(9-10-40-29)28-20-45(26-6-2-1-3-7-26)42-30(28)22-5-4-8-27(46)15-22/h1-10,15-20,46H,11-14H2,(H,41,47) OAOJPWQOBWFKLR-UHFFFAOYSA-N 50592469 CHEMBL5178484 Mitogen-activated protein kinase 10 Homo sapiens >1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592469&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168274208 482603321 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468164 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2ccc(F)cc2)c1)-c1ccccc1 InChI=1S/C29H25FN6O2/c30-22-9-11-23(12-10-22)34-29(38)33-16-15-32-27-18-20(13-14-31-27)26-19-36(24-6-2-1-3-7-24)35-28(26)21-5-4-8-25(37)17-21/h1-14,17-19,37H,15-16H2,(H,31,32)(H2,33,34,38) DOPVRNNEAOBWGJ-UHFFFAOYSA-N 50592447 CHEMBL5196004 Mitogen-activated protein kinase 10 Homo sapiens 191 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592447&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168287659 482603299 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468165 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2ccc(Cl)c(Cl)c2)c1)-c1ccccc1 InChI=1S/C29H24Cl2N6O2/c30-25-10-9-21(17-26(25)31)35-29(39)34-14-13-33-27-16-19(11-12-32-27)24-18-37(22-6-2-1-3-7-22)36-28(24)20-5-4-8-23(38)15-20/h1-12,15-18,38H,13-14H2,(H,32,33)(H2,34,35,39) HZYXNQSQNJIKGP-UHFFFAOYSA-N 50592448 CHEMBL5183673 Mitogen-activated protein kinase 10 Homo sapiens 525 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592448&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168282124 482603300 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468166 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2cccc(c2)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C30H25F3N6O2/c31-30(32,33)22-7-5-8-23(18-22)37-29(41)36-15-14-35-27-17-20(12-13-34-27)26-19-39(24-9-2-1-3-10-24)38-28(26)21-6-4-11-25(40)16-21/h1-13,16-19,40H,14-15H2,(H,34,35)(H2,36,37,41) HGCVWICUBZDORS-UHFFFAOYSA-N 50592449 CHEMBL5201911 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592449&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168291900 482603301 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468167 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C30H24ClF3N6O2/c31-26-10-9-21(17-25(26)30(32,33)34)38-29(42)37-14-13-36-27-16-19(11-12-35-27)24-18-40(22-6-2-1-3-7-22)39-28(24)20-5-4-8-23(41)15-20/h1-12,15-18,41H,13-14H2,(H,35,36)(H2,37,38,42) HLWFBXQPNMBWJJ-UHFFFAOYSA-N 50592450 CHEMBL5190930 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592450&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168286888 482603302 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468168 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C31H24F6N6O2/c32-30(33,34)21-15-22(31(35,36)37)17-23(16-21)41-29(45)40-12-11-39-27-14-19(9-10-38-27)26-18-43(24-6-2-1-3-7-24)42-28(26)20-5-4-8-25(44)13-20/h1-10,13-18,44H,11-12H2,(H,38,39)(H2,40,41,45) XYJHOOBOWOGYAJ-UHFFFAOYSA-N 50592451 CHEMBL5190777 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592451&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168280450 482603303 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468169 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2ccc(F)cc2)c1)-c1ccccc1 InChI=1S/C30H27FN6O2/c31-23-10-12-24(13-11-23)35-30(39)34-16-5-15-32-28-19-21(14-17-33-28)27-20-37(25-7-2-1-3-8-25)36-29(27)22-6-4-9-26(38)18-22/h1-4,6-14,17-20,38H,5,15-16H2,(H,32,33)(H2,34,35,39) BCNMJLRKWYKBBZ-UHFFFAOYSA-N 50592452 CHEMBL5191468 Mitogen-activated protein kinase 10 Homo sapiens 98 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592452&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168287868 482603304 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468170 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2ccc(Cl)c(Cl)c2)c1)-c1ccccc1 InChI=1S/C30H26Cl2N6O2/c31-26-11-10-22(18-27(26)32)36-30(40)35-14-5-13-33-28-17-20(12-15-34-28)25-19-38(23-7-2-1-3-8-23)37-29(25)21-6-4-9-24(39)16-21/h1-4,6-12,15-19,39H,5,13-14H2,(H,33,34)(H2,35,36,40) OHFPWTGFGYZHEC-UHFFFAOYSA-N 50592453 CHEMBL5177988 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592453&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168277407 482603305 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468171 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2cccc(c2)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C31H27F3N6O2/c32-31(33,34)23-8-5-9-24(19-23)38-30(42)37-15-6-14-35-28-18-21(13-16-36-28)27-20-40(25-10-2-1-3-11-25)39-29(27)22-7-4-12-26(41)17-22/h1-5,7-13,16-20,41H,6,14-15H2,(H,35,36)(H2,37,38,42) KEZRNSQBXOWDMI-UHFFFAOYSA-N 50592454 CHEMBL5205920 Mitogen-activated protein kinase 10 Homo sapiens 479 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592454&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168294873 482603306 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468172 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C31H26ClF3N6O2/c32-27-11-10-22(18-26(27)31(33,34)35)39-30(43)38-14-5-13-36-28-17-20(12-15-37-28)25-19-41(23-7-2-1-3-8-23)40-29(25)21-6-4-9-24(42)16-21/h1-4,6-12,15-19,42H,5,13-14H2,(H,36,37)(H2,38,39,43) RNPFZSNLWOSMIW-UHFFFAOYSA-N 50592455 CHEMBL5179126 Mitogen-activated protein kinase 10 Homo sapiens 617 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592455&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168272253 482603307 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468173 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C32H26F6N6O2/c33-31(34,35)22-16-23(32(36,37)38)18-24(17-22)42-30(46)41-12-5-11-39-28-15-20(10-13-40-28)27-19-44(25-7-2-1-3-8-25)43-29(27)21-6-4-9-26(45)14-21/h1-4,6-10,13-19,45H,5,11-12H2,(H,39,40)(H2,41,42,46) XNEURSCKWYCFQX-UHFFFAOYSA-N 50592456 CHEMBL5206891 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592456&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168295429 482603308 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468174 COc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2ccc(F)cc2)c1)-c1ccccc1 InChI=1S/C31H29FN6O2/c1-40-27-10-5-7-23(19-27)30-28(21-38(37-30)26-8-3-2-4-9-26)22-15-18-34-29(20-22)33-16-6-17-35-31(39)36-25-13-11-24(32)12-14-25/h2-5,7-15,18-21H,6,16-17H2,1H3,(H,33,34)(H2,35,36,39) BBDDFAGBJKUSTL-UHFFFAOYSA-N 50592457 CHEMBL5182819 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592457&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168282482 482603309 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468175 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccccc1)-c1ccccc1 InChI=1S/C32H30N6O2/c1-40-28-14-8-9-25(21-28)31-29(23-38(35-31)27-12-6-3-7-13-27)24-15-16-33-30(22-24)36-17-19-37(20-18-36)32(39)34-26-10-4-2-5-11-26/h2-16,21-23H,17-20H2,1H3,(H,34,39) GKHDVYYMZFVABP-UHFFFAOYSA-N 50592458 CHEMBL5173811 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592458&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168276456 482603310 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468176 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(F)cc1)-c1ccccc1 InChI=1S/C32H29FN6O2/c1-41-28-9-5-6-24(20-28)31-29(22-39(36-31)27-7-3-2-4-8-27)23-14-15-34-30(21-23)37-16-18-38(19-17-37)32(40)35-26-12-10-25(33)11-13-26/h2-15,20-22H,16-19H2,1H3,(H,35,40) LUYQCPFUZIYKJS-UHFFFAOYSA-N 50592459 CHEMBL5190656 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592459&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168281964 482603311 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468177 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(Cl)c1)-c1ccccc1 InChI=1S/C32H28Cl2N6O2/c1-42-26-9-5-6-23(18-26)31-27(21-40(37-31)25-7-3-2-4-8-25)22-12-13-35-30(19-22)38-14-16-39(17-15-38)32(41)36-24-10-11-28(33)29(34)20-24/h2-13,18-21H,14-17H2,1H3,(H,36,41) MULVGZBQVRJAIQ-UHFFFAOYSA-N 50592460 CHEMBL5206209 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592460&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168296987 482603312 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468178 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cccc(c1)C(F)(F)F)-c1ccccc1 InChI=1S/C33H29F3N6O2/c1-44-28-12-5-7-24(19-28)31-29(22-42(39-31)27-10-3-2-4-11-27)23-13-14-37-30(20-23)40-15-17-41(18-16-40)32(43)38-26-9-6-8-25(21-26)33(34,35)36/h2-14,19-22H,15-18H2,1H3,(H,38,43) NWCQTCRZIKMCPD-UHFFFAOYSA-N 50592461 CHEMBL5180621 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592461&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168275936 482603313 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468179 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)-c1ccccc1 InChI=1S/C33H28ClF3N6O2/c1-45-26-9-5-6-23(18-26)31-27(21-43(40-31)25-7-3-2-4-8-25)22-12-13-38-30(19-22)41-14-16-42(17-15-41)32(44)39-24-10-11-29(34)28(20-24)33(35,36)37/h2-13,18-21H,14-17H2,1H3,(H,39,44) XKWSFNDEMWBYOK-UHFFFAOYSA-N 50592462 CHEMBL5176396 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592462&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168278134 482603314 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468180 COc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)-c1ccccc1 InChI=1S/C34H28F6N6O2/c1-48-28-9-5-6-23(16-28)31-29(21-46(43-31)27-7-3-2-4-8-27)22-10-11-41-30(17-22)44-12-14-45(15-13-44)32(47)42-26-19-24(33(35,36)37)18-25(20-26)34(38,39)40/h2-11,16-21H,12-15H2,1H3,(H,42,47) SETUZDZATNQNPE-UHFFFAOYSA-N 50592463 CHEMBL5175285 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592463&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168275733 482603315 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468181 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccccc1)-c1ccccc1 InChI=1S/C31H28N6O2/c38-27-13-7-8-24(20-27)30-28(22-37(34-30)26-11-5-2-6-12-26)23-14-15-32-29(21-23)35-16-18-36(19-17-35)31(39)33-25-9-3-1-4-10-25/h1-15,20-22,38H,16-19H2,(H,33,39) IIFODDWMFNMVPV-UHFFFAOYSA-N 50592464 CHEMBL5199545 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592464&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168290953 482603316 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468182 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(F)cc1)-c1ccccc1 InChI=1S/C31H27FN6O2/c32-24-9-11-25(12-10-24)34-31(40)37-17-15-36(16-18-37)29-20-22(13-14-33-29)28-21-38(26-6-2-1-3-7-26)35-30(28)23-5-4-8-27(39)19-23/h1-14,19-21,39H,15-18H2,(H,34,40) DYVICTWHFCUYNP-UHFFFAOYSA-N 50592465 CHEMBL5171564 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592465&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168269200 482603317 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468183 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(Cl)c1)-c1ccccc1 InChI=1S/C31H26Cl2N6O2/c32-27-10-9-23(19-28(27)33)35-31(41)38-15-13-37(14-16-38)29-18-21(11-12-34-29)26-20-39(24-6-2-1-3-7-24)36-30(26)22-5-4-8-25(40)17-22/h1-12,17-20,40H,13-16H2,(H,35,41) WLWYMADLURCSIU-UHFFFAOYSA-N 50592466 CHEMBL5197538 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592466&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168284474 482603318 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468184 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cccc(c1)C(F)(F)F)-c1ccccc1 InChI=1S/C32H27F3N6O2/c33-32(34,35)24-7-5-8-25(20-24)37-31(43)40-16-14-39(15-17-40)29-19-22(12-13-36-29)28-21-41(26-9-2-1-3-10-26)38-30(28)23-6-4-11-27(42)18-23/h1-13,18-21,42H,14-17H2,(H,37,43) PYTYPQIAQRSIDG-UHFFFAOYSA-N 50592467 CHEMBL5174880 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592467&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168275728 482603319 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468185 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)-c1ccccc1 InChI=1S/C32H26ClF3N6O2/c33-28-10-9-23(19-27(28)32(34,35)36)38-31(44)41-15-13-40(14-16-41)29-18-21(11-12-37-29)26-20-42(24-6-2-1-3-7-24)39-30(26)22-5-4-8-25(43)17-22/h1-12,17-20,43H,13-16H2,(H,38,44) XJAJDOWMQVDEOT-UHFFFAOYSA-N 50592468 CHEMBL5179338 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592468&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168275513 482603320 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468186 Oc1cccc(c1)-c1nn(cc1-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)-c1ccccc1 InChI=1S/C33H26F6N6O2/c34-32(35,36)23-17-24(33(37,38)39)19-25(18-23)41-31(47)44-13-11-43(12-14-44)29-16-21(9-10-40-29)28-20-45(26-6-2-1-3-7-26)42-30(28)22-5-4-8-27(46)15-22/h1-10,15-20,46H,11-14H2,(H,41,47) OAOJPWQOBWFKLR-UHFFFAOYSA-N 50592469 CHEMBL5178484 Mitogen-activated protein kinase 10 Homo sapiens 1000 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592469&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168274208 482603321 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468191 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCNC(=O)Nc2cccc(c2)C(F)(F)F)c1)-c1ccccc1 InChI=1S/C30H25F3N6O2/c31-30(32,33)22-7-5-8-23(18-22)37-29(41)36-15-14-35-27-17-20(12-13-34-27)26-19-39(24-9-2-1-3-10-24)38-28(26)21-6-4-11-25(40)16-21/h1-13,16-19,40H,14-15H2,(H,34,35)(H2,36,37,41) HGCVWICUBZDORS-UHFFFAOYSA-N 50592449 CHEMBL5201911 Mitogen-activated protein kinase 10 Homo sapiens 3920 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592449&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168291900 482603301 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468192 Oc1cccc(c1)-c1nn(cc1-c1ccnc(NCCCNC(=O)Nc2ccc(F)cc2)c1)-c1ccccc1 InChI=1S/C30H27FN6O2/c31-23-10-12-24(13-11-23)35-30(39)34-16-5-15-32-28-19-21(14-17-33-28)27-20-37(25-7-2-1-3-8-25)36-29(27)22-6-4-9-26(38)18-22/h1-4,6-14,17-20,38H,5,15-16H2,(H,32,33)(H2,34,35,39) BCNMJLRKWYKBBZ-UHFFFAOYSA-N 50592452 CHEMBL5191468 Mitogen-activated protein kinase 10 Homo sapiens 3840 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592452&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 168287868 482603304 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51468193 CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1Cl InChI=1S/C22H24ClN7O/c1-24-21(31)17-4-2-3-5-19(17)28-20-18(23)14-26-22(29-20)27-15-6-8-16(9-7-15)30-12-10-25-11-13-30/h2-9,14,25H,10-13H2,1H3,(H,24,31)(H2,26,27,28,29) FCLOIQHNUARDSR-UHFFFAOYSA-N 50592470 CHEMBL5189795 Mitogen-activated protein kinase 10 Homo sapiens 370 ChEMBL 10.7270/Q2474FVC 35764033 Abu Rabah, RR; Sebastian, A; Vunnam, S; Sultan, S; Tarazi, H; Anbar, HS; Shehata, MK; Zaraei, SO; Elgendy, SM; Al Shamma, SA; Omar, HA; Al-Tel, TH; El-Gamal, MI University of Sharjah http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592470&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 71558939 482603322 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51492097 C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H10N2/c1-2-6-11-9(4-1)8-10-5-3-7-12-13(10)14(11)16-15-12/h1-7H,8H2,(H,15,16) SLMJDPXFWRYMLU-UHFFFAOYSA-N 50515269 CHEMBL4462592 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.7270/Q22Z19M2 33481605 Xie, Z; Yang, X; Duan, Y; Han, J; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515269&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 155529132 440723851 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51492098 N#CC(c1nc2ccccc2s1)c1ccnc(OCc2ccc(CN3CCOCC3)cc2)n1 InChI=1S/C25H23N5O2S/c26-15-20(24-28-22-3-1-2-4-23(22)33-24)21-9-10-27-25(29-21)32-17-19-7-5-18(6-8-19)16-30-11-13-31-14-12-30/h1-10,20H,11-14,16-17H2 XCPPIJCBCWUBNT-UHFFFAOYSA-N 50601418 AS602801::As-602801::BENTAMAPIMOD::Bentamapimod::PGL-5001::PGL5001 Mitogen-activated protein kinase 10 Homo sapiens 230 ChEMBL 10.7270/Q22Z19M2 33481605 Xie, Z; Yang, X; Duan, Y; Han, J; Liao, C Hefei University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50601418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50601418&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10195250 482612270 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51524331 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ RADRIIWGHYFWPP-WEVVVXLNSA-N 86632 JNK-IN-7 Mitogen-activated protein kinase 10 Homo sapiens 13 ChEMBL 10.7270/Q22V2MDF 30108900 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340685 136352681 ZINC87723492 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989045 CSc1nc(c([nH]1)-c1ccnc(Nc2ccc(N)cc2)c1)-c1ccc(F)cc1 InChI=1S/C21H18FN5S/c1-28-21-26-19(13-2-4-15(22)5-3-13)20(27-21)14-10-11-24-18(12-14)25-17-8-6-16(23)7-9-17/h2-12H,23H2,1H3,(H,24,25)(H,26,27) ZTEDFSIIEDNHLZ-UHFFFAOYSA-N 50234888 CHEMBL4074524 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234888&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137641182 384584940 CHEMBL4074524 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989047 Cc1ccc(OC[C@@H](O)[C@@H]2CCCCN2)cc1 InChI=1S/C14H21NO2/c1-11-5-7-12(8-6-11)17-10-14(16)13-4-2-3-9-15-13/h5-8,13-16H,2-4,9-10H2,1H3/t13-,14+/m0/s1 XEHSYSYFUMPVBX-UONOGXRCSA-N 50405622 CHEMBL5271950 Mitogen-activated protein kinase 10 Homo sapiens 4.7 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405622&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 21595420 163354646 CHEMBL67631 ZINC26249292 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989048 COCCn1c(SC)nc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1 InChI=1S/C20H21FN4O2S/c1-13(26)23-17-12-15(8-9-22-17)19-18(14-4-6-16(21)7-5-14)24-20(28-3)25(19)10-11-27-2/h4-9,12H,10-11H2,1-3H3,(H,22,23,26) VNWXBCDASDHBCA-UHFFFAOYSA-N 50156820 CHEMBL426183::N-{4-[5-(4-fluorophenyl)-3-(2-methoxyethyl)-2-methylsulfanyl-3H-imidazol-4-yl]pyridin-2-yl}acetamide Mitogen-activated protein kinase 10 Homo sapiens 202 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156820&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11304134 104043881 CHEMBL426183 ZINC13586220 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989049 CC(=O)Nc1cc(ccn1)-c1c(nc(S\C=C/C(O)=O)n1CC1CC1)-c1ccc(F)cc1 InChI=1S/C23H21FN4O3S/c1-14(29)26-19-12-17(8-10-25-19)22-21(16-4-6-18(24)7-5-16)27-23(32-11-9-20(30)31)28(22)13-15-2-3-15/h4-12,15H,2-3,13H2,1H3,(H,30,31)(H,25,26,29)/b11-9- PPJNVHSJLHVKBI-LUAWRHEFSA-N 50103104 CHEMBL3394106 Mitogen-activated protein kinase 10 Homo sapiens 18 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103104&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 101913690 318491142 CHEMBL3394106 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989050 Cc1ccc(OC[C@@H](O)[C@H]2CCCCN2)cc1 InChI=1S/C14H21NO2/c1-11-5-7-12(8-6-11)17-10-14(16)13-4-2-3-9-15-13/h5-8,13-16H,2-4,9-10H2,1H3/t13-,14-/m1/s1 XEHSYSYFUMPVBX-ZIAGYGMSSA-N 50405623 CHEMBL5287474 Mitogen-activated protein kinase 10 Homo sapiens 26 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405623&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 14201545 163354647 CHEMBL304725 ZINC26267064 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989052 C[S+]([O-])c1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1 50045333 CHEBI:90705::SB-203580 Mitogen-activated protein kinase 10 Homo sapiens 720 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50045333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50045333&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 176155 313068400 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989054 O[C@H](COCCCc1ccccc1)[C@@H]1CCCCN1 InChI=1S/C16H25NO2/c18-16(15-10-4-5-11-17-15)13-19-12-6-9-14-7-2-1-3-8-14/h1-3,7-8,15-18H,4-6,9-13H2/t15-,16+/m0/s1 PAWPHGFYSPEYBZ-JKSUJKDBSA-N 50405624 CHEMBL5284967 Mitogen-activated protein kinase 10 Homo sapiens 48 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405624&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 21595423 163354648 CHEMBL66324 ZINC26253179 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989055 O[C@H](COc1cccc2ccccc12)[C@@H]1CCCCN1 InChI=1S/C17H21NO2/c19-16(15-9-3-4-11-18-15)12-20-17-10-5-7-13-6-1-2-8-14(13)17/h1-2,5-8,10,15-16,18-19H,3-4,9,11-12H2/t15-,16+/m0/s1 HDRKGMUPXWTLAN-JKSUJKDBSA-N 50405625 CHEMBL5274433 Mitogen-activated protein kinase 10 Homo sapiens 74 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405625&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 21595418 163354649 CHEMBL304344 ZINC26248524 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989061 CC(C)C(C)Nc1cc(ccn1)-c1nc(SCCO)[nH]c1-c1ccc(F)cc1 InChI=1S/C21H25FN4OS/c1-13(2)14(3)24-18-12-16(8-9-23-18)20-19(15-4-6-17(22)7-5-15)25-21(26-20)28-11-10-27/h4-9,12-14,27H,10-11H2,1-3H3,(H,23,24)(H,25,26) WWSBAAXRYHTMOX-UHFFFAOYSA-N 50253320 2-(4-(4-Fluorophenyl)-5-(2-(3-methylbutan-2-ylamino)pyridin-4-yl)-1H-imidazol-2-ylthio)ethanol::CHEMBL524174 Mitogen-activated protein kinase 10 Homo sapiens 181 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50253320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50253320&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 24805930 104105868 CHEMBL524174 ZINC40954779 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989062 CSc1nc(c(-c2ccnc(Nc3ccc(NC(=O)c4cccc(NC(=O)C=C)c4)cc3)c2)n1C)-c1ccc(F)cc1 InChI=1S/C32H27FN6O2S/c1-4-28(40)36-26-7-5-6-22(18-26)31(41)37-25-14-12-24(13-15-25)35-27-19-21(16-17-34-27)30-29(38-32(42-3)39(30)2)20-8-10-23(33)11-9-20/h4-19H,1H2,2-3H3,(H,34,35)(H,36,40)(H,37,41) SHSDJTLZMWMUMU-UHFFFAOYSA-N 50234890 CHEMBL4077018 Mitogen-activated protein kinase 10 Homo sapiens 0.300000 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50234890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50234890&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137650943 384584942 CHEMBL4077018 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989064 CSc1nc(C)c([nH]1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)c1 InChI=1S/C20H23N5OS/c1-14-19(24-20(22-14)27-2)15-7-8-21-18(13-15)23-16-3-5-17(6-4-16)25-9-11-26-12-10-25/h3-8,13H,9-12H2,1-2H3,(H,21,23)(H,22,24) IATSSYNKRCFJAY-UHFFFAOYSA-N 50599929 CHEMBL5194871 Mitogen-activated protein kinase 10 Homo sapiens 184 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50599929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50599929&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search B9K 6EKD 134693850 482610781 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989065 O[C@H](COc1cccc2ccccc12)[C@H]1CCCCN1 InChI=1S/C17H21NO2/c19-16(15-9-3-4-11-18-15)12-20-17-10-5-7-13-6-1-2-8-14(13)17/h1-2,5-8,10,15-16,18-19H,3-4,9,11-12H2/t15-,16-/m1/s1 HDRKGMUPXWTLAN-HZPDHXFCSA-N 50405626 CHEMBL5269500 Mitogen-activated protein kinase 10 Homo sapiens 433 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405626&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 13267804 163354650 CHEMBL69635 ZINC26264304 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 50989068 Cc1cccc(OC[C@@H](O)[C@H]2CCCCN2)c1 InChI=1S/C14H21NO2/c1-11-5-4-6-12(9-11)17-10-14(16)13-7-2-3-8-15-13/h4-6,9,13-16H,2-3,7-8,10H2,1H3/t13-,14-/m1/s1 PMIQTCHQVGVLMI-ZIAGYGMSSA-N 50405627 CHEMBL5281537 Mitogen-activated protein kinase 10 Homo sapiens 94 ChEMBL 10.7270/Q28056T7 36490325 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405627&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 14201542 163354651 CHEMBL68996 ZINC26265690 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 1JNK,1PMN,1PMU,1PMV,1UKH,1UKI,2B1P,2EXC,2O0U,2O2U,2OK1,2P33,2R9S,2WAJ,2XRW,2XS0,2ZDT,2ZDU,3CGF,3CGO,3DA6,3FI3,3G90,3G9L,3G9N,3KVX,3OXI,3OY1,3PTG,3PZE,3RTP,3TTI,3TTJ,3V6R,3V6S,3VUD,4E73,4G1W,4H36,4H39,4H3B,4HYS,4HYU,4IZY,4KKE,4KKG,4KKH,4U79,4W4V,4W4W,4W4X,4W4Y,4WHZ,4Y46,4Y5H,4YR8,4Z9L,7KSI,7KSJ,7KSK,7S1N,7YL1,8BZP,8ENJ,8WGF,8X5M Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51545996 Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C4)C(=O)C4CC4)n3)c2c1 InChI=1S/C30H28N6O2/c37-24-11-12-25-26(17-24)36(28(33-25)22-10-7-19-4-1-2-5-21(19)16-22)27-13-14-31-30(34-27)32-23-6-3-15-35(18-23)29(38)20-8-9-20/h1-2,4-5,7,10-14,16-17,20,23,37H,3,6,8-9,15,18H2,(H,31,32,34)/t23-/m0/s1 GQWKCVUFYCHSLR-QHCPKHFHSA-N 50621792 CHEMBL5437462 Mitogen-activated protein kinase 10 Homo sapiens 4.0 ChEMBL 10.1021/acs.jmedchem.3c00393 10.7270/Q2V98DF9 37094094 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621792&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51545997 CNC(=O)Oc1ccc2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C4)C(=O)C4CC4)n3)c2c1 InChI=1S/C32H31N7O3/c1-33-32(41)42-25-12-13-26-27(18-25)39(29(36-26)23-11-8-20-5-2-3-6-22(20)17-23)28-14-15-34-31(37-28)35-24-7-4-16-38(19-24)30(40)21-9-10-21/h2-3,5-6,8,11-15,17-18,21,24H,4,7,9-10,16,19H2,1H3,(H,33,41)(H,34,35,37)/t24-/m0/s1 UVXXVTKNDYEVAL-DEOSSOPVSA-N 50621793 CHEMBL5418625 Mitogen-activated protein kinase 10 Homo sapiens 53 ChEMBL 10.1021/acs.jmedchem.3c00393 10.7270/Q2V98DF9 37094094 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621793&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51545998 Oc1cc(F)c2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C4)C(=O)C4CC4)n3)c2c1 InChI=1S/C30H27FN6O2/c31-24-15-23(38)16-25-27(24)35-28(21-10-7-18-4-1-2-5-20(18)14-21)37(25)26-11-12-32-30(34-26)33-22-6-3-13-36(17-22)29(39)19-8-9-19/h1-2,4-5,7,10-12,14-16,19,22,38H,3,6,8-9,13,17H2,(H,32,33,34)/t22-/m0/s1 PLVJKHRAOBBOKV-QFIPXVFZSA-N 50621794 CHEMBL5430912 Mitogen-activated protein kinase 10 Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.3c00393 10.7270/Q2V98DF9 37094094 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621794&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51545999 CNC(=O)Oc1cc(F)c2nc(-c3ccc4ccccc4c3)n(-c3ccnc(N[C@H]4CCCN(C4)C(=O)C4CC4)n3)c2c1 InChI=1S/C32H30FN7O3/c1-34-32(42)43-24-16-25(33)28-26(17-24)40(29(38-28)22-11-8-19-5-2-3-6-21(19)15-22)27-12-13-35-31(37-27)36-23-7-4-14-39(18-23)30(41)20-9-10-20/h2-3,5-6,8,11-13,15-17,20,23H,4,7,9-10,14,18H2,1H3,(H,34,42)(H,35,36,37)/t23-/m0/s1 CWLAIOPWFOOJHQ-QHCPKHFHSA-N 50621795 CHEMBL5438365 Mitogen-activated protein kinase 10 Homo sapiens 21 ChEMBL 10.1021/acs.jmedchem.3c00393 10.7270/Q2V98DF9 37094094 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621795&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51546000 O=C(C1CC1)N1CCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1 InChI=1S/C28H27N7O/c29-13-11-24-17-31-26(22-10-7-19-4-1-2-5-21(19)16-22)35(24)25-12-14-30-28(33-25)32-23-6-3-15-34(18-23)27(36)20-8-9-20/h1-2,4-5,7,10,12,14,16-17,20,23H,3,6,8-9,11,15,18H2,(H,30,32,33)/t23-/m0/s1 MIFPZJRPCSILQA-QHCPKHFHSA-N 50621796 CHEMBL5396715 Mitogen-activated protein kinase 10 Homo sapiens 1.000000 ChEMBL 10.1021/acs.jmedchem.3c00393 10.7270/Q2V98DF9 37094094 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621796&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51546256 CCOc1cc(ccc1Nc1ncc2cc(-c3cccc(NC(=O)c4cccc(c4)C(F)(F)F)c3)c(=O)n(C[C@H]3CCCO3)c2n1)N1CCN(C)CC1 InChI=1S/C39H40F3N7O4/c1-3-52-34-22-30(48-16-14-47(2)15-17-48)12-13-33(34)45-38-43-23-27-21-32(37(51)49(35(27)46-38)24-31-11-6-18-53-31)25-7-5-10-29(20-25)44-36(50)26-8-4-9-28(19-26)39(40,41)42/h4-5,7-10,12-13,19-23,31H,3,6,11,14-18,24H2,1-2H3,(H,44,50)(H,43,45,46)/t31-/m1/s1 RONKBVWJPIOCJX-WJOKGBTCSA-N 50621890 CHEMBL5415503 Mitogen-activated protein kinase 10 Homo sapiens 23 ChEMBL 10.1021/acs.jmedchem.3c00319 10.7270/Q2TF02QS 37134203 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621890&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51549162 CCS(=O)(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1 InChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25) BGLPECHZZQDNCD-UHFFFAOYSA-N 50468574 CHEMBL4116008::US11414410, Example 100 Mitogen-activated protein kinase 10 Homo sapiens 4.0 ChEMBL 10.1016/j.ejmech.2022.114551 10.7270/Q23F4V2S 35749986 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50468574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50468574&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search S5I 8BX6 44595079 433935839 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573957 CCOC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H28F4N6O3/c1-2-41-26(40)17-12-21-22(13-17)38(24(35-21)16-5-6-20(29)19(11-16)28(30,31)32)23-7-9-33-27(36-23)34-18-8-10-37(14-18)25(39)15-3-4-15/h5-7,9,11,15,17-18H,2-4,8,10,12-14H2,1H3,(H,33,34,36)/t17?,18-/m0/s1 AEWBSJTXVXLCAY-ZVAWYAOSSA-N 50633125 CHEMBL5398830 Mitogen-activated protein kinase 10 Homo sapiens 453 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633125&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573958 NC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H25F4N7O2/c27-18-4-3-14(9-17(18)26(28,29)30)23-34-19-10-15(22(31)38)11-20(19)37(23)21-5-7-32-25(35-21)33-16-6-8-36(12-16)24(39)13-1-2-13/h3-5,7,9,13,15-16H,1-2,6,8,10-12H2,(H2,31,38)(H,32,33,35)/t15?,16-/m0/s1 SXQDTTHBQYQAML-LYKKTTPLSA-N 50633126 CHEMBL5410846 Mitogen-activated protein kinase 10 Homo sapiens 183 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633126&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573959 CNC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H27F4N7O2/c1-32-24(39)16-11-20-21(12-16)38(23(35-20)15-4-5-19(28)18(10-15)27(29,30)31)22-6-8-33-26(36-22)34-17-7-9-37(13-17)25(40)14-2-3-14/h4-6,8,10,14,16-17H,2-3,7,9,11-13H2,1H3,(H,32,39)(H,33,34,36)/t16?,17-/m0/s1 JMTMKDYFYPOURD-DJNXLDHESA-N 50633127 CHEMBL5415588 Mitogen-activated protein kinase 10 Homo sapiens 601 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633127&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573960 CCOC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H28F4N6O3/c1-2-41-26(40)17-12-21-22(13-17)38(24(35-21)16-5-6-20(29)19(11-16)28(30,31)32)23-7-9-33-27(36-23)34-18-8-10-37(14-18)25(39)15-3-4-15/h5-7,9,11,15,17-18H,2-4,8,10,12-14H2,1H3,(H,33,34,36)/t17?,18-/m1/s1 AEWBSJTXVXLCAY-QRWMCTBCSA-N 50633128 CHEMBL5426262 Mitogen-activated protein kinase 10 Homo sapiens 63 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633128&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573961 NC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H25F4N7O2/c27-18-4-3-14(9-17(18)26(28,29)30)23-34-19-10-15(22(31)38)11-20(19)37(23)21-5-7-32-25(35-21)33-16-6-8-36(12-16)24(39)13-1-2-13/h3-5,7,9,13,15-16H,1-2,6,8,10-12H2,(H2,31,38)(H,32,33,35)/t15?,16-/m1/s1 SXQDTTHBQYQAML-OEMAIJDKSA-N 50633129 CHEMBL5397833 Mitogen-activated protein kinase 10 Homo sapiens 300 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633129&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573962 CNC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H27F4N7O2/c1-32-24(39)16-11-20-21(12-16)38(23(35-20)15-4-5-19(28)18(10-15)27(29,30)31)22-6-8-33-26(36-22)34-17-7-9-37(13-17)25(40)14-2-3-14/h4-6,8,10,14,16-17H,2-3,7,9,11-13H2,1H3,(H,32,39)(H,33,34,36)/t16?,17-/m1/s1 JMTMKDYFYPOURD-ZYMOGRSISA-N 50633130 CHEMBL5425684 Mitogen-activated protein kinase 10 Homo sapiens 300 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633130&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573963 CCOC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C29H30F4N6O3/c1-2-42-27(41)18-13-22-23(14-18)39(25(36-22)17-7-8-21(30)20(12-17)29(31,32)33)24-9-10-34-28(37-24)35-19-4-3-11-38(15-19)26(40)16-5-6-16/h7-10,12,16,18-19H,2-6,11,13-15H2,1H3,(H,34,35,37)/t18?,19-/m0/s1 NJDOTNDYLDZVQF-GGYWPGCISA-N 50633131 CHEMBL5436272 Mitogen-activated protein kinase 10 Homo sapiens 53 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633131&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573964 NC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H27F4N7O2/c28-19-6-5-15(10-18(19)27(29,30)31)24-35-20-11-16(23(32)39)12-21(20)38(24)22-7-8-33-26(36-22)34-17-2-1-9-37(13-17)25(40)14-3-4-14/h5-8,10,14,16-17H,1-4,9,11-13H2,(H2,32,39)(H,33,34,36)/t16?,17-/m0/s1 XKYYEKJWALXUHB-DJNXLDHESA-N 50633132 CHEMBL5425334 Mitogen-activated protein kinase 10 Homo sapiens 6.4 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633132&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573965 CNC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H29F4N7O2/c1-33-25(40)17-12-21-22(13-17)39(24(36-21)16-6-7-20(29)19(11-16)28(30,31)32)23-8-9-34-27(37-23)35-18-3-2-10-38(14-18)26(41)15-4-5-15/h6-9,11,15,17-18H,2-5,10,12-14H2,1H3,(H,33,40)(H,34,35,37)/t17?,18-/m0/s1 DLUZWUITPRGWCU-ZVAWYAOSSA-N 50633133 CHEMBL5433276 Mitogen-activated protein kinase 10 Homo sapiens 31 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633133&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573966 CCOC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C29H30F4N6O3/c1-2-42-27(41)18-13-22-23(14-18)39(25(36-22)17-7-8-21(30)20(12-17)29(31,32)33)24-9-10-34-28(37-24)35-19-4-3-11-38(15-19)26(40)16-5-6-16/h7-10,12,16,18-19H,2-6,11,13-15H2,1H3,(H,34,35,37)/t18?,19-/m1/s1 NJDOTNDYLDZVQF-MUMRKEEXSA-N 50633134 CHEMBL5399618 Mitogen-activated protein kinase 10 Homo sapiens 65 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633134&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573967 NC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H27F4N7O2/c28-19-6-5-15(10-18(19)27(29,30)31)24-35-20-11-16(23(32)39)12-21(20)38(24)22-7-8-33-26(36-22)34-17-2-1-9-37(13-17)25(40)14-3-4-14/h5-8,10,14,16-17H,1-4,9,11-13H2,(H2,32,39)(H,33,34,36)/t16?,17-/m1/s1 XKYYEKJWALXUHB-ZYMOGRSISA-N 50633135 CHEMBL5403762 Mitogen-activated protein kinase 10 Homo sapiens 104 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633135&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573968 CNC(=O)C1Cc2nc(-c3ccc(F)c(c3)C(F)(F)F)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H29F4N7O2/c1-33-25(40)17-12-21-22(13-17)39(24(36-21)16-6-7-20(29)19(11-16)28(30,31)32)23-8-9-34-27(37-23)35-18-3-2-10-38(14-18)26(41)15-4-5-15/h6-9,11,15,17-18H,2-5,10,12-14H2,1H3,(H,33,40)(H,34,35,37)/t17?,18-/m1/s1 DLUZWUITPRGWCU-QRWMCTBCSA-N 50633136 CHEMBL5423272 Mitogen-activated protein kinase 10 Homo sapiens 700 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633136&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573969 CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H28Cl2N6O3/c1-2-38-26(37)17-12-21-22(13-17)35(24(32-21)16-5-6-19(28)20(29)11-16)23-7-9-30-27(33-23)31-18-8-10-34(14-18)25(36)15-3-4-15/h5-7,9,11,15,17-18H,2-4,8,10,12-14H2,1H3,(H,30,31,33)/t17?,18-/m0/s1 WEGMIRDEVYCIQA-ZVAWYAOSSA-N 50633137 CHEMBL5402048 Mitogen-activated protein kinase 10 Homo sapiens 28 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633137&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573970 NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C25H25Cl2N7O2/c26-17-4-3-14(9-18(17)27)23-31-19-10-15(22(28)35)11-20(19)34(23)21-5-7-29-25(32-21)30-16-6-8-33(12-16)24(36)13-1-2-13/h3-5,7,9,13,15-16H,1-2,6,8,10-12H2,(H2,28,35)(H,29,30,32)/t15?,16-/m0/s1 RBPCHHCRWJKFEW-LYKKTTPLSA-N 50633138 CHEMBL5423677 Mitogen-activated protein kinase 10 Homo sapiens 15 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633138&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573971 CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H27Cl2N7O2/c1-29-24(36)16-11-20-21(12-16)35(23(32-20)15-4-5-18(27)19(28)10-15)22-6-8-30-26(33-22)31-17-7-9-34(13-17)25(37)14-2-3-14/h4-6,8,10,14,16-17H,2-3,7,9,11-13H2,1H3,(H,29,36)(H,30,31,33)/t16?,17-/m0/s1 AWIMCQNUPFHNLK-DJNXLDHESA-N 50633139 CHEMBL5412347 Mitogen-activated protein kinase 10 Homo sapiens 10 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633139&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573972 CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H28Cl2N6O3/c1-2-38-26(37)17-12-21-22(13-17)35(24(32-21)16-5-6-19(28)20(29)11-16)23-7-9-30-27(33-23)31-18-8-10-34(14-18)25(36)15-3-4-15/h5-7,9,11,15,17-18H,2-4,8,10,12-14H2,1H3,(H,30,31,33)/t17?,18-/m1/s1 WEGMIRDEVYCIQA-QRWMCTBCSA-N 50633140 CHEMBL5438506 Mitogen-activated protein kinase 10 Homo sapiens 4.3 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633140&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573973 NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C25H25Cl2N7O2/c26-17-4-3-14(9-18(17)27)23-31-19-10-15(22(28)35)11-20(19)34(23)21-5-7-29-25(32-21)30-16-6-8-33(12-16)24(36)13-1-2-13/h3-5,7,9,13,15-16H,1-2,6,8,10-12H2,(H2,28,35)(H,29,30,32)/t15?,16-/m1/s1 RBPCHHCRWJKFEW-OEMAIJDKSA-N 50633141 CHEMBL5420339 Mitogen-activated protein kinase 10 Homo sapiens 16 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633141&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573974 CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H27Cl2N7O2/c1-29-24(36)16-11-20-21(12-16)35(23(32-20)15-4-5-18(27)19(28)10-15)22-6-8-30-26(33-22)31-17-7-9-34(13-17)25(37)14-2-3-14/h4-6,8,10,14,16-17H,2-3,7,9,11-13H2,1H3,(H,29,36)(H,30,31,33)/t16?,17-/m1/s1 AWIMCQNUPFHNLK-ZYMOGRSISA-N 50633142 CHEMBL5436510 Mitogen-activated protein kinase 10 Homo sapiens 9.4 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633142&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573975 CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H30Cl2N6O3/c1-2-39-27(38)18-13-22-23(14-18)36(25(33-22)17-7-8-20(29)21(30)12-17)24-9-10-31-28(34-24)32-19-4-3-11-35(15-19)26(37)16-5-6-16/h7-10,12,16,18-19H,2-6,11,13-15H2,1H3,(H,31,32,34)/t18?,19-/m0/s1 QWBLRTCRXZETHI-GGYWPGCISA-N 50633143 CHEMBL5429577 Mitogen-activated protein kinase 10 Homo sapiens 1.1 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633143&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573976 NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H27Cl2N7O2/c27-18-6-5-15(10-19(18)28)24-32-20-11-16(23(29)36)12-21(20)35(24)22-7-8-30-26(33-22)31-17-2-1-9-34(13-17)25(37)14-3-4-14/h5-8,10,14,16-17H,1-4,9,11-13H2,(H2,29,36)(H,30,31,33)/t16?,17-/m0/s1 MKHLHLAXBRMALM-DJNXLDHESA-N 50633144 CHEMBL5403678 Mitogen-activated protein kinase 10 Homo sapiens 0.379000 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633144&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573977 CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H29Cl2N7O2/c1-30-25(37)17-12-21-22(13-17)36(24(33-21)16-6-7-19(28)20(29)11-16)23-8-9-31-27(34-23)32-18-3-2-10-35(14-18)26(38)15-4-5-15/h6-9,11,15,17-18H,2-5,10,12-14H2,1H3,(H,30,37)(H,31,32,34)/t17?,18-/m0/s1 KDAMBQMCWSCLEM-ZVAWYAOSSA-N 50633145 CHEMBL5408675 Mitogen-activated protein kinase 10 Homo sapiens 1.2 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633145&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573978 CCOC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H30Cl2N6O3/c1-2-39-27(38)18-13-22-23(14-18)36(25(33-22)17-7-8-20(29)21(30)12-17)24-9-10-31-28(34-24)32-19-4-3-11-35(15-19)26(37)16-5-6-16/h7-10,12,16,18-19H,2-6,11,13-15H2,1H3,(H,31,32,34)/t18?,19-/m1/s1 QWBLRTCRXZETHI-MUMRKEEXSA-N 50633146 CHEMBL5411160 Mitogen-activated protein kinase 10 Homo sapiens 0.607000 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633146&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573979 NC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H27Cl2N7O2/c27-18-6-5-15(10-19(18)28)24-32-20-11-16(23(29)36)12-21(20)35(24)22-7-8-30-26(33-22)31-17-2-1-9-34(13-17)25(37)14-3-4-14/h5-8,10,14,16-17H,1-4,9,11-13H2,(H2,29,36)(H,30,31,33)/t16?,17-/m1/s1 MKHLHLAXBRMALM-ZYMOGRSISA-N 50633147 CHEMBL5398642 Mitogen-activated protein kinase 10 Homo sapiens 0.730000 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633147&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573980 CNC(=O)C1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H29Cl2N7O2/c1-30-25(37)17-12-21-22(13-17)36(24(33-21)16-6-7-19(28)20(29)11-16)23-8-9-31-27(34-23)32-18-3-2-10-35(14-18)26(38)15-4-5-15/h6-9,11,15,17-18H,2-5,10,12-14H2,1H3,(H,30,37)(H,31,32,34)/t17?,18-/m1/s1 KDAMBQMCWSCLEM-QRWMCTBCSA-N 50633148 CHEMBL5424892 Mitogen-activated protein kinase 10 Homo sapiens 4.8 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633148&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573981 CCOC(=O)C1Cc2nc(-c3ccc4OCCc4c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C29H32N6O4/c1-2-38-28(37)20-14-22-23(15-20)35(26(32-22)19-5-6-24-18(13-19)9-12-39-24)25-7-10-30-29(33-25)31-21-8-11-34(16-21)27(36)17-3-4-17/h5-7,10,13,17,20-21H,2-4,8-9,11-12,14-16H2,1H3,(H,30,31,33)/t20?,21-/m0/s1 JWMSFDMVSCIHAH-LBAQZLPGSA-N 50633149 CHEMBL5428039 Mitogen-activated protein kinase 10 Homo sapiens 158 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633149&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573982 NC(=O)C1Cc2nc(-c3ccc4OCCc4c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H29N7O3/c28-24(35)18-12-20-21(13-18)34(25(31-20)17-3-4-22-16(11-17)7-10-37-22)23-5-8-29-27(32-23)30-19-6-9-33(14-19)26(36)15-1-2-15/h3-5,8,11,15,18-19H,1-2,6-7,9-10,12-14H2,(H2,28,35)(H,29,30,32)/t18?,19-/m0/s1 SENNPTARPYDLDL-GGYWPGCISA-N 50633150 CHEMBL5424108 Mitogen-activated protein kinase 10 Homo sapiens 87 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633150&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573983 CCOC(=O)C1Cc2nc(-c3ccc4OCCc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C29H32N6O4/c1-2-38-28(37)20-14-22-23(15-20)35(26(32-22)19-5-6-24-18(13-19)9-12-39-24)25-7-10-30-29(33-25)31-21-8-11-34(16-21)27(36)17-3-4-17/h5-7,10,13,17,20-21H,2-4,8-9,11-12,14-16H2,1H3,(H,30,31,33)/t20?,21-/m1/s1 JWMSFDMVSCIHAH-BPGUCPLFSA-N 50633151 CHEMBL5401605 Mitogen-activated protein kinase 10 Homo sapiens 22 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633151&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573984 NC(=O)C1Cc2nc(-c3ccc4OCCc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H29N7O3/c28-24(35)18-12-20-21(13-18)34(25(31-20)17-3-4-22-16(11-17)7-10-37-22)23-5-8-29-27(32-23)30-19-6-9-33(14-19)26(36)15-1-2-15/h3-5,8,11,15,18-19H,1-2,6-7,9-10,12-14H2,(H2,28,35)(H,29,30,32)/t18?,19-/m1/s1 SENNPTARPYDLDL-MUMRKEEXSA-N 50633152 CHEMBL5418507 Mitogen-activated protein kinase 10 Homo sapiens 63 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633152&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573985 CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23) KQMPRSZTUSSXND-UHFFFAOYSA-N 15908 Aminopyridine-Based Inhibitor 6o::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide::aminopyridine deriv. 2 Mitogen-activated protein kinase 10 Homo sapiens 14 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15908&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11624601 46516179 5998 ZINC14959960 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573986 CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C31H32N6O3/c1-2-40-30(39)23-16-25-26(17-23)37(28(34-25)22-10-7-19-5-3-4-6-21(19)15-22)27-11-13-32-31(35-27)33-24-12-14-36(18-24)29(38)20-8-9-20/h3-7,10-11,13,15,20,23-24H,2,8-9,12,14,16-18H2,1H3,(H,32,33,35)/t23?,24-/m0/s1 VHSDKELMOZIECC-CGAIIQECSA-N 50633153 CHEMBL5403970 Mitogen-activated protein kinase 10 Homo sapiens 23 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633153&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573987 NC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C29H29N7O2/c30-26(37)21-14-23-24(15-21)36(27(33-23)20-8-5-17-3-1-2-4-19(17)13-20)25-9-11-31-29(34-25)32-22-10-12-35(16-22)28(38)18-6-7-18/h1-5,8-9,11,13,18,21-22H,6-7,10,12,14-16H2,(H2,30,37)(H,31,32,34)/t21?,22-/m0/s1 LIJMACARAIRPNI-KEKNWZKVSA-N 50633154 CHEMBL5436937 Mitogen-activated protein kinase 10 Homo sapiens 15 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633154&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573988 CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C31H32N6O3/c1-2-40-30(39)23-16-25-26(17-23)37(28(34-25)22-10-7-19-5-3-4-6-21(19)15-22)27-11-13-32-31(35-27)33-24-12-14-36(18-24)29(38)20-8-9-20/h3-7,10-11,13,15,20,23-24H,2,8-9,12,14,16-18H2,1H3,(H,32,33,35)/t23?,24-/m1/s1 VHSDKELMOZIECC-XMMISQBUSA-N 50633155 CHEMBL5405705 Mitogen-activated protein kinase 10 Homo sapiens 6.8 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633155&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573989 NC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C29H29N7O2/c30-26(37)21-14-23-24(15-21)36(27(33-23)20-8-5-17-3-1-2-4-19(17)13-20)25-9-11-31-29(34-25)32-22-10-12-35(16-22)28(38)18-6-7-18/h1-5,8-9,11,13,18,21-22H,6-7,10,12,14-16H2,(H2,30,37)(H,31,32,34)/t21?,22-/m1/s1 LIJMACARAIRPNI-FOIFJWKZSA-N 50633156 CHEMBL5395372 Mitogen-activated protein kinase 10 Homo sapiens 25 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633156&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573990 CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C32H34N6O3/c1-2-41-31(40)24-17-26-27(18-24)38(29(35-26)23-12-9-20-6-3-4-7-22(20)16-23)28-13-14-33-32(36-28)34-25-8-5-15-37(19-25)30(39)21-10-11-21/h3-4,6-7,9,12-14,16,21,24-25H,2,5,8,10-11,15,17-19H2,1H3,(H,33,34,36)/t24?,25-/m0/s1 SGYOIXNBCYRZBZ-BBMPLOMVSA-N 50633157 CHEMBL5436023 Mitogen-activated protein kinase 10 Homo sapiens 0.716000 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633157&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573991 NC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C30H31N7O2/c31-27(38)22-15-24-25(16-22)37(28(34-24)21-10-7-18-4-1-2-5-20(18)14-21)26-11-12-32-30(35-26)33-23-6-3-13-36(17-23)29(39)19-8-9-19/h1-2,4-5,7,10-12,14,19,22-23H,3,6,8-9,13,15-17H2,(H2,31,38)(H,32,33,35)/t22?,23-/m0/s1 ZPUSWRDJKBKBRX-WCSIJFPASA-N 50633158 CHEMBL5399794 Mitogen-activated protein kinase 10 Homo sapiens 1.8 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633158&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573992 CNC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C31H33N7O2/c1-32-29(39)23-16-25-26(17-23)38(28(35-25)22-11-8-19-5-2-3-6-21(19)15-22)27-12-13-33-31(36-27)34-24-7-4-14-37(18-24)30(40)20-9-10-20/h2-3,5-6,8,11-13,15,20,23-24H,4,7,9-10,14,16-18H2,1H3,(H,32,39)(H,33,34,36)/t23?,24-/m0/s1 VSVFDMDYNXAZHL-CGAIIQECSA-N 50633159 CHEMBL5423620 Mitogen-activated protein kinase 10 Homo sapiens 0.564000 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633159&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573993 CCOC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C32H34N6O3/c1-2-41-31(40)24-17-26-27(18-24)38(29(35-26)23-12-9-20-6-3-4-7-22(20)16-23)28-13-14-33-32(36-28)34-25-8-5-15-37(19-25)30(39)21-10-11-21/h3-4,6-7,9,12-14,16,21,24-25H,2,5,8,10-11,15,17-19H2,1H3,(H,33,34,36)/t24?,25-/m1/s1 SGYOIXNBCYRZBZ-WUBHUQEYSA-N 50633160 CHEMBL5401511 Mitogen-activated protein kinase 10 Homo sapiens 0.779000 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633160&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573994 NC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C30H31N7O2/c31-27(38)22-15-24-25(16-22)37(28(34-24)21-10-7-18-4-1-2-5-20(18)14-21)26-11-12-32-30(35-26)33-23-6-3-13-36(17-23)29(39)19-8-9-19/h1-2,4-5,7,10-12,14,19,22-23H,3,6,8-9,13,15-17H2,(H2,31,38)(H,32,33,35)/t22?,23-/m1/s1 ZPUSWRDJKBKBRX-OZAIVSQSSA-N 50633161 CHEMBL5430858 Mitogen-activated protein kinase 10 Homo sapiens 1.7 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633161&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573995 CNC(=O)C1Cc2nc(-c3ccc4ccccc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C31H33N7O2/c1-32-29(39)23-16-25-26(17-23)38(28(35-25)22-11-8-19-5-2-3-6-21(19)15-22)27-12-13-33-31(36-27)34-24-7-4-14-37(18-24)30(40)20-9-10-20/h2-3,5-6,8,11-13,15,20,23-24H,4,7,9-10,14,16-18H2,1H3,(H,32,39)(H,33,34,36)/t23?,24-/m1/s1 VSVFDMDYNXAZHL-XMMISQBUSA-N 50633162 CHEMBL5424946 Mitogen-activated protein kinase 10 Homo sapiens 1.1 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633162&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573996 CCOC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H30N6O5/c1-2-37-27(36)18-11-20-21(12-18)34(25(31-20)17-5-6-22-23(13-17)39-15-38-22)24-7-9-29-28(32-24)30-19-8-10-33(14-19)26(35)16-3-4-16/h5-7,9,13,16,18-19H,2-4,8,10-12,14-15H2,1H3,(H,29,30,32)/t18?,19-/m0/s1 RKBAKKFIGMZCDD-GGYWPGCISA-N 50633163 CHEMBL5439571 Mitogen-activated protein kinase 10 Homo sapiens 243 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633163&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573997 NC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H27N7O4/c27-23(34)16-9-18-19(10-16)33(24(30-18)15-3-4-20-21(11-15)37-13-36-20)22-5-7-28-26(31-22)29-17-6-8-32(12-17)25(35)14-1-2-14/h3-5,7,11,14,16-17H,1-2,6,8-10,12-13H2,(H2,27,34)(H,28,29,31)/t16?,17-/m0/s1 HTKZVRGBBRJGKS-DJNXLDHESA-N 50633164 CHEMBL5407257 Mitogen-activated protein kinase 10 Homo sapiens 135 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633164&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573998 CNC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H29N7O4/c1-28-25(35)17-10-19-20(11-17)34(24(31-19)16-4-5-21-22(12-16)38-14-37-21)23-6-8-29-27(32-23)30-18-7-9-33(13-18)26(36)15-2-3-15/h4-6,8,12,15,17-18H,2-3,7,9-11,13-14H2,1H3,(H,28,35)(H,29,30,32)/t17?,18-/m0/s1 ZHQZAFCOCGENSL-ZVAWYAOSSA-N 50633165 CHEMBL5406704 Mitogen-activated protein kinase 10 Homo sapiens 180 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633165&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573999 CCOC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H30N6O5/c1-2-37-27(36)18-11-20-21(12-18)34(25(31-20)17-5-6-22-23(13-17)39-15-38-22)24-7-9-29-28(32-24)30-19-8-10-33(14-19)26(35)16-3-4-16/h5-7,9,13,16,18-19H,2-4,8,10-12,14-15H2,1H3,(H,29,30,32)/t18?,19-/m1/s1 RKBAKKFIGMZCDD-MUMRKEEXSA-N 50633166 CHEMBL5416188 Mitogen-activated protein kinase 10 Homo sapiens 50 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633166&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574000 NC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C26H27N7O4/c27-23(34)16-9-18-19(10-16)33(24(30-18)15-3-4-20-21(11-15)37-13-36-20)22-5-7-28-26(31-22)29-17-6-8-32(12-17)25(35)14-1-2-14/h3-5,7,11,14,16-17H,1-2,6,8-10,12-13H2,(H2,27,34)(H,28,29,31)/t16?,17-/m1/s1 HTKZVRGBBRJGKS-ZYMOGRSISA-N 50633167 CHEMBL5422901 Mitogen-activated protein kinase 10 Homo sapiens 103 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633167&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574001 CNC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H29N7O4/c1-28-25(35)17-10-19-20(11-17)34(24(31-19)16-4-5-21-22(12-16)38-14-37-21)23-6-8-29-27(32-23)30-18-7-9-33(13-18)26(36)15-2-3-15/h4-6,8,12,15,17-18H,2-3,7,9-11,13-14H2,1H3,(H,28,35)(H,29,30,32)/t17?,18-/m1/s1 ZHQZAFCOCGENSL-QRWMCTBCSA-N 50633168 CHEMBL5423313 Mitogen-activated protein kinase 10 Homo sapiens 94 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633168&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574002 CCOC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C29H32N6O5/c1-2-38-28(37)19-12-21-22(13-19)35(26(32-21)18-7-8-23-24(14-18)40-16-39-23)25-9-10-30-29(33-25)31-20-4-3-11-34(15-20)27(36)17-5-6-17/h7-10,14,17,19-20H,2-6,11-13,15-16H2,1H3,(H,30,31,33)/t19?,20-/m0/s1 WENOAQSVDGOFKK-ANYOKISRSA-N 50633169 CHEMBL5413870 Mitogen-activated protein kinase 10 Homo sapiens 11 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633169&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574003 NC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H29N7O4/c28-24(35)17-10-19-20(11-17)34(25(31-19)16-5-6-21-22(12-16)38-14-37-21)23-7-8-29-27(32-23)30-18-2-1-9-33(13-18)26(36)15-3-4-15/h5-8,12,15,17-18H,1-4,9-11,13-14H2,(H2,28,35)(H,29,30,32)/t17?,18-/m0/s1 NUZKAZXBJGHDQU-ZVAWYAOSSA-N 50633170 CHEMBL5401592 Mitogen-activated protein kinase 10 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633170&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574004 CCOC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C29H32N6O5/c1-2-38-28(37)19-12-21-22(13-19)35(26(32-21)18-7-8-23-24(14-18)40-16-39-23)25-9-10-30-29(33-25)31-20-4-3-11-34(15-20)27(36)17-5-6-17/h7-10,14,17,19-20H,2-6,11-13,15-16H2,1H3,(H,30,31,33)/t19?,20-/m1/s1 WENOAQSVDGOFKK-GFOWMXPYSA-N 50633171 CHEMBL5431060 Mitogen-activated protein kinase 10 Homo sapiens 1.2 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633171&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574005 NC(=O)C1Cc2nc(-c3ccc4OCOc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C27H29N7O4/c28-24(35)17-10-19-20(11-17)34(25(31-19)16-5-6-21-22(12-16)38-14-37-21)23-7-8-29-27(32-23)30-18-2-1-9-33(13-18)26(36)15-3-4-15/h5-8,12,15,17-18H,1-4,9-11,13-14H2,(H2,28,35)(H,29,30,32)/t17?,18-/m1/s1 NUZKAZXBJGHDQU-QRWMCTBCSA-N 50633172 CHEMBL5427166 Mitogen-activated protein kinase 10 Homo sapiens 36 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633172&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574006 CCOC(=O)C1Cc2nc(-c3ccc4OCCc4c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C30H34N6O4/c1-2-39-29(38)21-15-23-24(16-21)36(27(33-23)20-7-8-25-19(14-20)10-13-40-25)26-9-11-31-30(34-26)32-22-4-3-12-35(17-22)28(37)18-5-6-18/h7-9,11,14,18,21-22H,2-6,10,12-13,15-17H2,1H3,(H,31,32,34)/t21?,22-/m0/s1 NRHCAWSLJCINNX-KEKNWZKVSA-N 50633173 CHEMBL5431146 Mitogen-activated protein kinase 10 Homo sapiens 31 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633173&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574007 NC(=O)C1Cc2nc(-c3ccc4OCCc4c3)n(c2C1)-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H31N7O3/c29-25(36)19-13-21-22(14-19)35(26(32-21)18-5-6-23-17(12-18)8-11-38-23)24-7-9-30-28(33-24)31-20-2-1-10-34(15-20)27(37)16-3-4-16/h5-7,9,12,16,19-20H,1-4,8,10-11,13-15H2,(H2,29,36)(H,30,31,33)/t19?,20-/m0/s1 RAZYKDWHVGAGCG-ANYOKISRSA-N 50633174 CHEMBL5435809 Mitogen-activated protein kinase 10 Homo sapiens 9.1 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633174&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574008 CCOC(=O)C1Cc2nc(-c3ccc4OCCc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C30H34N6O4/c1-2-39-29(38)21-15-23-24(16-21)36(27(33-23)20-7-8-25-19(14-20)10-13-40-25)26-9-11-31-30(34-26)32-22-4-3-12-35(17-22)28(37)18-5-6-18/h7-9,11,14,18,21-22H,2-6,10,12-13,15-17H2,1H3,(H,31,32,34)/t21?,22-/m1/s1 NRHCAWSLJCINNX-FOIFJWKZSA-N 50633175 CHEMBL5414227 Mitogen-activated protein kinase 10 Homo sapiens 10 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633175&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574009 NC(=O)C1Cc2nc(-c3ccc4OCCc4c3)n(c2C1)-c1ccnc(N[C@@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C28H31N7O3/c29-25(36)19-13-21-22(14-19)35(26(32-21)18-5-6-23-17(12-18)8-11-38-23)24-7-9-30-28(33-24)31-20-2-1-10-34(15-20)27(37)16-3-4-16/h5-7,9,12,16,19-20H,1-4,8,10-11,13-15H2,(H2,29,36)(H,30,31,33)/t19?,20-/m1/s1 RAZYKDWHVGAGCG-GFOWMXPYSA-N 50633176 CHEMBL5419594 Mitogen-activated protein kinase 10 Homo sapiens 8.9 ChEMBL 10.1016/j.ejmech.2022.114917 10.7270/Q29K4GQ0 36395646 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633176&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574388 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574389 Fc1ccc2NC(=O)\C(=C3/N\C(SC3=O)=N\c3ccccc3Cl)c2c1 InChI=1S/C17H9ClFN3O2S/c18-10-3-1-2-4-12(10)21-17-22-14(16(24)25-17)13-9-7-8(19)5-6-11(9)20-15(13)23/h1-7H,(H,20,23)(H,21,22)/b14-13- BXSCAZNZCUPHEP-YPKPFQOOSA-N 50633297 CHEMBL5410493 Mitogen-activated protein kinase 10 Homo sapiens 100 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633297&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574390 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3ccccc3F)c2c1 InChI=1S/C17H9F2N3O2S/c18-8-5-6-11-9(7-8)13(15(23)20-11)14-16(24)22-17(25-14)21-12-4-2-1-3-10(12)19/h1-7H,(H,20,23)(H,21,22,24)/b14-13- RMOYNGSHDNLYOR-YPKPFQOOSA-N 50633298 CHEMBL5439177 Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633298&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574391 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(F)c3F)c2c1 InChI=1S/C17H8F3N3O2S/c18-7-4-5-10-8(6-7)12(15(24)21-10)14-16(25)23-17(26-14)22-11-3-1-2-9(19)13(11)20/h1-6H,(H,21,24)(H,22,23,25)/b14-12- CRUAHXHFDXQJTM-OWBHPGMISA-N 50633299 CHEMBL5410221 Mitogen-activated protein kinase 10 Homo sapiens 95 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633299&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574392 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3c(F)cccc3F)c2c1 InChI=1S/C17H8F3N3O2S/c18-7-4-5-11-8(6-7)12(15(24)21-11)14-16(25)23-17(26-14)22-13-9(19)2-1-3-10(13)20/h1-6H,(H,21,24)(H,22,23,25)/b14-12- LAGVCSVOTSETDO-OWBHPGMISA-N 50633300 CHEMBL5404244 Mitogen-activated protein kinase 10 Homo sapiens 140 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633300&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574393 [O-][N+](=O)c1ccccc1\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(F)cc12 InChI=1S/C17H9FN4O4S/c18-8-5-6-10-9(7-8)13(15(23)19-10)14-16(24)21-17(27-14)20-11-3-1-2-4-12(11)22(25)26/h1-7H,(H,19,23)(H,20,21,24)/b14-13- DUHHHOBMKXPPPP-YPKPFQOOSA-N 50633301 CHEMBL5430890 Mitogen-activated protein kinase 10 Homo sapiens 740 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633301&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574394 COc1ccccc1\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(F)cc12 InChI=1S/C18H12FN3O3S/c1-25-13-5-3-2-4-12(13)21-18-22-17(24)15(26-18)14-10-8-9(19)6-7-11(10)20-16(14)23/h2-8H,1H3,(H,20,23)(H,21,22,24)/b15-14- GCJVGFJBPVRHGF-PFONDFGASA-N 50633302 CHEMBL5423835 Mitogen-activated protein kinase 10 Homo sapiens 92 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633302&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574395 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C17H8Cl2FN3O2S/c18-9-2-1-3-11(13(9)19)22-17-23-16(25)14(26-17)12-8-6-7(20)4-5-10(8)21-15(12)24/h1-6H,(H,21,24)(H,22,23,25)/b14-12- RILZQDMICBCVCA-OWBHPGMISA-N 50633303 CHEMBL5416936 Mitogen-activated protein kinase 10 Homo sapiens 13 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633303&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574396 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(F)c3Cl)c2c1 InChI=1S/C17H8ClF2N3O2S/c18-13-9(20)2-1-3-11(13)22-17-23-16(25)14(26-17)12-8-6-7(19)4-5-10(8)21-15(12)24/h1-6H,(H,21,24)(H,22,23,25)/b14-12- POWJOCBYAWOKND-OWBHPGMISA-N 50633304 CHEMBL5421436 Mitogen-activated protein kinase 10 Homo sapiens 530 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633304&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574397 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3F)c2c1 InChI=1S/C17H8ClF2N3O2S/c18-9-2-1-3-11(13(9)20)22-17-23-16(25)14(26-17)12-8-6-7(19)4-5-10(8)21-15(12)24/h1-6H,(H,21,24)(H,22,23,25)/b14-12- BGVLHDSLWIGMBY-OWBHPGMISA-N 50633305 CHEMBL5426713 Mitogen-activated protein kinase 10 Homo sapiens 84 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633305&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574398 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3c(Cl)cccc3Cl)c2c1 InChI=1S/C17H8Cl2FN3O2S/c18-9-2-1-3-10(19)13(9)22-17-23-16(25)14(26-17)12-8-6-7(20)4-5-11(8)21-15(12)24/h1-6H,(H,21,24)(H,22,23,25)/b14-12- QVOSGHYQVHVFNH-OWBHPGMISA-N 50633306 CHEMBL5426371 Mitogen-activated protein kinase 10 Homo sapiens 3720 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633306&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574399 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3c(Cl)ccc(Cl)c3Cl)c2c1 InChI=1S/C17H7Cl3FN3O2S/c18-8-2-3-9(19)13(12(8)20)23-17-24-16(26)14(27-17)11-7-5-6(21)1-4-10(7)22-15(11)25/h1-5H,(H,22,25)(H,23,24,26)/b14-11- GPLWGFPWJPSOBO-KAMYIIQDSA-N 50633307 CHEMBL5419312 Mitogen-activated protein kinase 10 Homo sapiens 1530 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633307&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574400 Clc1ccccc1\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccccc12 InChI=1S/C17H10ClN3O2S/c18-10-6-2-4-8-12(10)20-17-21-16(23)14(24-17)13-9-5-1-3-7-11(9)19-15(13)22/h1-8H,(H,19,22)(H,20,21,23)/b14-13- CWCAAHDFSQUHPZ-YPKPFQOOSA-N 50633308 CHEMBL5405724 Mitogen-activated protein kinase 10 Homo sapiens 220 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633308&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574401 Clc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3ccccc3Cl)c2c1 InChI=1S/C17H9Cl2N3O2S/c18-8-5-6-11-9(7-8)13(15(23)20-11)14-16(24)22-17(25-14)21-12-4-2-1-3-10(12)19/h1-7H,(H,20,23)(H,21,22,24)/b14-13- AIFUDKGTKISRNV-YPKPFQOOSA-N 50633309 CHEMBL5408939 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633309&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574402 Clc1ccccc1\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(Br)cc12 InChI=1S/C17H9BrClN3O2S/c18-8-5-6-11-9(7-8)13(15(23)20-11)14-16(24)22-17(25-14)21-12-4-2-1-3-10(12)19/h1-7H,(H,20,23)(H,21,22,24)/b14-13- LZUQNBVAKVGMIG-YPKPFQOOSA-N 50633310 CHEMBL5416863 Mitogen-activated protein kinase 10 Homo sapiens 300 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633310&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574403 Clc1cccc(c1)\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccccc12 InChI=1S/C17H10ClN3O2S/c18-9-4-3-5-10(8-9)19-17-21-16(23)14(24-17)13-11-6-1-2-7-12(11)20-15(13)22/h1-8H,(H,20,22)(H,19,21,23)/b14-13- GYCGVQRHVFYVEK-YPKPFQOOSA-N 50633311 CHEMBL5426261 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633311&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574404 Fc1ccccc1\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(Cl)cc12 InChI=1S/C17H9ClFN3O2S/c18-8-5-6-11-9(7-8)13(15(23)20-11)14-16(24)22-17(25-14)21-12-4-2-1-3-10(12)19/h1-7H,(H,20,23)(H,21,22,24)/b14-13- UVNDJWNGZFNHKD-YPKPFQOOSA-N 50633312 CHEMBL5410150 Mitogen-activated protein kinase 10 Homo sapiens 78 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633312&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574405 Fc1cccc(F)c1\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(Cl)cc12 InChI=1S/C17H8ClF2N3O2S/c18-7-4-5-11-8(6-7)12(15(24)21-11)14-16(25)23-17(26-14)22-13-9(19)2-1-3-10(13)20/h1-6H,(H,21,24)(H,22,23,25)/b14-12- HLAAXETVYJLJDI-OWBHPGMISA-N 50633313 CHEMBL5423129 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633313&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574406 Clc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C17H8Cl3N3O2S/c18-7-4-5-10-8(6-7)12(15(24)21-10)14-16(25)23-17(26-14)22-11-3-1-2-9(19)13(11)20/h1-6H,(H,21,24)(H,22,23,25)/b14-12- WIRYPTJCDMKAIN-OWBHPGMISA-N 50633314 CHEMBL5402716 Mitogen-activated protein kinase 10 Homo sapiens 27 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633314&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574407 Clc1ccccc1\N=C1/NC(=O)\C(S1)=C1\C(=O)Nc2ccc(I)cc12 InChI=1S/C17H9ClIN3O2S/c18-10-3-1-2-4-12(10)21-17-22-16(24)14(25-17)13-9-7-8(19)5-6-11(9)20-15(13)23/h1-7H,(H,20,23)(H,21,22,24)/b14-13- JAWKETQLYUVQEK-YPKPFQOOSA-N 50633315 CHEMBL5420689 Mitogen-activated protein kinase 10 Homo sapiens 63 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633315&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574408 [O-][N+](=O)c1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3ccccc3Cl)c2c1 InChI=1S/C17H9ClN4O4S/c18-10-3-1-2-4-12(10)20-17-21-16(24)14(27-17)13-9-7-8(22(25)26)5-6-11(9)19-15(13)23/h1-7H,(H,19,23)(H,20,21,24)/b14-13- SMQDMUJQSUPOLB-YPKPFQOOSA-N 50633316 CHEMBL5407582 Mitogen-activated protein kinase 10 Homo sapiens 96 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633316&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574409 Clc1cccc(\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccc(I)cc23)c1Cl InChI=1S/C17H8Cl2IN3O2S/c18-9-2-1-3-11(13(9)19)22-17-23-16(25)14(26-17)12-8-6-7(20)4-5-10(8)21-15(12)24/h1-6H,(H,21,24)(H,22,23,25)/b14-12- JGZUWKWACANJOH-OWBHPGMISA-N 50633317 CHEMBL5406765 Mitogen-activated protein kinase 10 Homo sapiens 110 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633317&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574410 [O-][N+](=O)c1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C17H8Cl2N4O4S/c18-9-2-1-3-11(13(9)19)21-17-22-16(25)14(28-17)12-8-6-7(23(26)27)4-5-10(8)20-15(12)24/h1-6H,(H,20,24)(H,21,22,25)/b14-12- PUIUPDZARFUUHO-OWBHPGMISA-N 50633318 CHEMBL5395599 Mitogen-activated protein kinase 10 Homo sapiens 89 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633318&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574411 Cc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C18H11Cl2N3O2S/c1-8-5-6-11-9(7-8)13(16(24)21-11)15-17(25)23-18(26-15)22-12-4-2-3-10(19)14(12)20/h2-7H,1H3,(H,21,24)(H,22,23,25)/b15-13- ZBYLQSZLVTVKFT-SQFISAMPSA-N 50633319 CHEMBL5426038 Mitogen-activated protein kinase 10 Homo sapiens 200 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633319&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574412 CN(C)c1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C19H14Cl2N4O2S/c1-25(2)9-6-7-12-10(8-9)14(17(26)22-12)16-18(27)24-19(28-16)23-13-5-3-4-11(20)15(13)21/h3-8H,1-2H3,(H,22,26)(H,23,24,27)/b16-14- OLNKDQHOYPRFIN-PEZBUJJGSA-N 50633320 CHEMBL5419547 Mitogen-activated protein kinase 10 Homo sapiens 810 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633320&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574413 Clc1cccc(\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccc(cc23)N2CCOCC2)c1Cl InChI=1S/C21H16Cl2N4O3S/c22-13-2-1-3-15(17(13)23)25-21-26-20(29)18(31-21)16-12-10-11(27-6-8-30-9-7-27)4-5-14(12)24-19(16)28/h1-5,10H,6-9H2,(H,24,28)(H,25,26,29)/b18-16- BDHPKQZHHUVMNC-VLGSPTGOSA-N 50633321 CHEMBL5429978 Mitogen-activated protein kinase 10 Homo sapiens 220 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633321&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574414 CC(=O)Nc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C19H12Cl2N4O3S/c1-8(26)22-9-5-6-12-10(7-9)14(17(27)23-12)16-18(28)25-19(29-16)24-13-4-2-3-11(20)15(13)21/h2-7H,1H3,(H,22,26)(H,23,27)(H,24,25,28)/b16-14- PDYKBILIDFANAY-PEZBUJJGSA-N 50633322 CHEMBL5406652 Mitogen-activated protein kinase 10 Homo sapiens 78 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633322&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574415 CN(C)CC(=O)Nc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C21H17Cl2N5O3S/c1-28(2)9-15(29)24-10-6-7-13-11(8-10)16(19(30)25-13)18-20(31)27-21(32-18)26-14-5-3-4-12(22)17(14)23/h3-8H,9H2,1-2H3,(H,24,29)(H,25,30)(H,26,27,31)/b18-16- OFFCXFOCWNSHBO-VLGSPTGOSA-N 50633323 CHEMBL5422182 Mitogen-activated protein kinase 10 Homo sapiens 530 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633323&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574416 CCN(CC)CC(=O)Nc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C23H21Cl2N5O3S/c1-3-30(4-2)11-17(31)26-12-8-9-15-13(10-12)18(21(32)27-15)20-22(33)29-23(34-20)28-16-7-5-6-14(24)19(16)25/h5-10H,3-4,11H2,1-2H3,(H,26,31)(H,27,32)(H,28,29,33)/b20-18- YAWLAARHXPCHIG-ZZEZOPTASA-N 50633324 CHEMBL5399045 Mitogen-activated protein kinase 10 Homo sapiens 690 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633324&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574417 Clc1cccc(\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccc(NC(=O)CN4CCCC4)cc23)c1Cl InChI=1S/C23H19Cl2N5O3S/c24-14-4-3-5-16(19(14)25)28-23-29-22(33)20(34-23)18-13-10-12(6-7-15(13)27-21(18)32)26-17(31)11-30-8-1-2-9-30/h3-7,10H,1-2,8-9,11H2,(H,26,31)(H,27,32)(H,28,29,33)/b20-18- HAQKOCWOSGWGQX-ZZEZOPTASA-N 50633325 CHEMBL5429870 Mitogen-activated protein kinase 10 Homo sapiens 440 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633325&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574418 Clc1cccc(\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccc(NC(=O)CN4CCCCC4)cc23)c1Cl InChI=1S/C24H21Cl2N5O3S/c25-15-5-4-6-17(20(15)26)29-24-30-23(34)21(35-24)19-14-11-13(7-8-16(14)28-22(19)33)27-18(32)12-31-9-2-1-3-10-31/h4-8,11H,1-3,9-10,12H2,(H,27,32)(H,28,33)(H,29,30,34)/b21-19- MADDYGYPZCGUCY-VZCXRCSSSA-N 50633326 CHEMBL5440479 Mitogen-activated protein kinase 10 Homo sapiens 770 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633326&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574419 CN(C)CCC(=O)Nc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C22H19Cl2N5O3S/c1-29(2)9-8-16(30)25-11-6-7-14-12(10-11)17(20(31)26-14)19-21(32)28-22(33-19)27-15-5-3-4-13(23)18(15)24/h3-7,10H,8-9H2,1-2H3,(H,25,30)(H,26,31)(H,27,28,32)/b19-17- WIFPAZVPCCTHDD-ZPHPHTNESA-N 50633327 CHEMBL5422757 Mitogen-activated protein kinase 10 Homo sapiens 520 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633327&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574420 CCN(CC)CCC(=O)Nc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C24H23Cl2N5O3S/c1-3-31(4-2)11-10-18(32)27-13-8-9-16-14(12-13)19(22(33)28-16)21-23(34)30-24(35-21)29-17-7-5-6-15(25)20(17)26/h5-9,12H,3-4,10-11H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,34)/b21-19- CTDJLPCGMPZAIH-VZCXRCSSSA-N 50633328 CHEMBL5440695 Mitogen-activated protein kinase 10 Homo sapiens 370 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633328&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574421 Clc1cccc(\N=C2/NC(=O)\C(S2)=C2\C(=O)Nc3ccc(NC(=O)CCN4CCCC4)cc23)c1Cl InChI=1S/C24H21Cl2N5O3S/c25-15-4-3-5-17(20(15)26)29-24-30-23(34)21(35-24)19-14-12-13(6-7-16(14)28-22(19)33)27-18(32)8-11-31-9-1-2-10-31/h3-7,12H,1-2,8-11H2,(H,27,32)(H,28,33)(H,29,30,34)/b21-19- SLSRJBMKFQMNIZ-VZCXRCSSSA-N 50633329 CHEMBL5401113 Mitogen-activated protein kinase 10 Homo sapiens 310 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633329&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574422 CN1CCC(CC1)C(=O)Nc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C24H21Cl2N5O3S/c1-31-9-7-12(8-10-31)21(32)27-13-5-6-16-14(11-13)18(22(33)28-16)20-23(34)30-24(35-20)29-17-4-2-3-15(25)19(17)26/h2-6,11-12H,7-10H2,1H3,(H,27,32)(H,28,33)(H,29,30,34)/b20-18- UKWLGNHJPRCBDE-ZZEZOPTASA-N 50633330 CHEMBL5432203 Mitogen-activated protein kinase 10 Homo sapiens 78 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633330&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574433 Fc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C17H8Cl2FN3O2S/c18-9-2-1-3-11(13(9)19)22-17-23-16(25)14(26-17)12-8-6-7(20)4-5-10(8)21-15(12)24/h1-6H,(H,21,24)(H,22,23,25)/b14-12- RILZQDMICBCVCA-OWBHPGMISA-N 50633303 CHEMBL5416936 Mitogen-activated protein kinase 10 Homo sapiens 13 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633303&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574434 Clc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C17H8Cl3N3O2S/c18-7-4-5-10-8(6-7)12(15(24)21-10)14-16(25)23-17(26-14)22-11-3-1-2-9(19)13(11)20/h1-6H,(H,21,24)(H,22,23,25)/b14-12- WIRYPTJCDMKAIN-OWBHPGMISA-N 50633314 CHEMBL5402716 Mitogen-activated protein kinase 10 Homo sapiens 27 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633314&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574435 CC(=O)Nc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C19H12Cl2N4O3S/c1-8(26)22-9-5-6-12-10(7-9)14(17(27)23-12)16-18(28)25-19(29-16)24-13-4-2-3-11(20)15(13)21/h2-7H,1H3,(H,22,26)(H,23,27)(H,24,25,28)/b16-14- PDYKBILIDFANAY-PEZBUJJGSA-N 50633322 CHEMBL5406652 Mitogen-activated protein kinase 10 Homo sapiens 78 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633322&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574436 CN1CCC(CC1)C(=O)Nc1ccc2NC(=O)\C(=C3/S\C(NC3=O)=N\c3cccc(Cl)c3Cl)c2c1 InChI=1S/C24H21Cl2N5O3S/c1-31-9-7-12(8-10-31)21(32)27-13-5-6-16-14(11-13)18(22(33)28-16)20-23(34)30-24(35-20)29-17-4-2-3-15(25)19(17)26/h2-6,11-12H,7-10H2,1H3,(H,27,32)(H,28,33)(H,29,30,34)/b20-18- UKWLGNHJPRCBDE-ZZEZOPTASA-N 50633330 CHEMBL5432203 Mitogen-activated protein kinase 10 Homo sapiens 78 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633330&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51574437 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1016/j.ejmech.2023.115167 10.7270/Q2RN3D94 36764123 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573780 Oc1c2cccc3[nH][nH]c(c23)c2ccccc12 InChI=1S/C14H10N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,15-17H BRKXAADNUXOTJZ-UHFFFAOYSA-N 50211302 5a,10c-Dihydro-2H-dibenzo[cd,g]indazol-6-one::CHEMBL252761 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211302&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10398628 104087500 CHEMBL252761 ZINC28966658 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573784 Oc1cc2nc(-c3ccc4OCCOc4c3)n(-c3ccnc(N[C@H]4CCCN(C4)C(=O)C4CC4)n3)c2cc1O InChI=1S/C28H28N6O5/c35-21-13-19-20(14-22(21)36)34(26(31-19)17-5-6-23-24(12-17)39-11-10-38-23)25-7-8-29-28(32-25)30-18-2-1-9-33(15-18)27(37)16-3-4-16/h5-8,12-14,16,18,35-36H,1-4,9-11,15H2,(H,29,30,32)/t18-/m0/s1 IGZDNHCOKONAHO-SFHVURJKSA-N 50633042 CHEMBL5408056 Mitogen-activated protein kinase 10 Homo sapiens 10.0 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633042&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573785 NC(=O)N1Cc2nc(-c3ccc(Cl)c(Cl)c3)n(c2C1)-c1ccnc(N[C@@H]2CCN(C2)C(=O)C2CC2)n1 InChI=1S/C24H24Cl2N8O2/c25-16-4-3-14(9-17(16)26)21-30-18-11-33(23(27)36)12-19(18)34(21)20-5-7-28-24(31-20)29-15-6-8-32(10-15)22(35)13-1-2-13/h3-5,7,9,13,15H,1-2,6,8,10-12H2,(H2,27,36)(H,28,29,31)/t15-/m1/s1 LGICVDGDWJJCIH-OAHLLOKOSA-N 50633043 CHEMBL5406554 Mitogen-activated protein kinase 10 Homo sapiens 3.0 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633043&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573786 N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C21H20N6O3/c22-7-3-16-12-24-20(14-1-2-17-18(11-14)30-13-29-17)27(16)19-4-8-23-21(26-19)25-15-5-9-28-10-6-15/h1-2,4,8,11-12,15H,3,5-6,9-10,13H2,(H,23,25,26) SVUITGIIKADDAF-UHFFFAOYSA-N 392707 Example 1::US10301291, Compound 10a Mitogen-activated protein kinase 10 Homo sapiens 8560 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392707&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389175 404961032 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573787 N#CCc1cnc(-c2ccc3OCCOc3c2)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C22H22N6O3/c23-7-3-17-14-25-21(15-1-2-18-19(13-15)31-12-11-30-18)28(17)20-4-8-24-22(27-20)26-16-5-9-29-10-6-16/h1-2,4,8,13-14,16H,3,5-6,9-12H2,(H,24,26,27) DXAYFEKMSRSNLO-UHFFFAOYSA-N 392708 Example 2::US10301291, Compound 10b Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392708&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389049 404961033 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573788 N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C23H21N7O/c24-11-7-18-15-26-22(20-6-5-16-3-1-2-4-19(16)28-20)30(18)21-8-12-25-23(29-21)27-17-9-13-31-14-10-17/h1-6,8,12,15,17H,7,9-10,13-14H2,(H,25,27,29) GHWROBLEMLUTAG-UHFFFAOYSA-N 392709 Example 3::US10301291, Compound 10c Mitogen-activated protein kinase 10 Homo sapiens 13500 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392709&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389196 404961034 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573789 N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C24H22N6O/c25-11-7-21-16-27-23(19-6-5-17-3-1-2-4-18(17)15-19)30(21)22-8-12-26-24(29-22)28-20-9-13-31-14-10-20/h1-6,8,12,15-16,20H,7,9-10,13-14H2,(H,26,28,29) QUHKJAZRLNYDCD-UHFFFAOYSA-N 392710 Example 4::US10301291, Compound 10d Mitogen-activated protein kinase 10 Homo sapiens 321 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392710&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389001 404961035 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573790 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C20H18Cl2N6O/c21-16-2-1-13(11-17(16)22)19-25-12-15(3-7-23)28(19)18-4-8-24-20(27-18)26-14-5-9-29-10-6-14/h1-2,4,8,11-12,14H,3,5-6,9-10H2,(H,24,26,27) JLBWDBPHKABVBE-UHFFFAOYSA-N 392711 Example 5::US10301291, Compound 10e Mitogen-activated protein kinase 10 Homo sapiens 290 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392711&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389309 404961036 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573791 Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCOCC2)n1 InChI=1S/C21H18F4N6O/c22-17-2-1-13(11-16(17)21(23,24)25)19-28-12-15(3-7-26)31(19)18-4-8-27-20(30-18)29-14-5-9-32-10-6-14/h1-2,4,8,11-12,14H,3,5-6,9-10H2,(H,27,29,30) QUAMEPWGALLEMV-UHFFFAOYSA-N 392712 Example 6::US10301291, Compound 10f Mitogen-activated protein kinase 10 Homo sapiens 421 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392712&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389219 404961037 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573792 N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C22H22N6O2/c23-10-8-17-13-25-21(15-6-7-18-19(12-15)30-14-29-18)28(17)20-9-11-24-22(27-20)26-16-4-2-1-3-5-16/h6-7,9,11-13,16H,1-5,8,14H2,(H,24,26,27) OFUMROLKEGKJMS-UHFFFAOYSA-N 392713 Example 7::US10301291, Compound 11a Mitogen-activated protein kinase 10 Homo sapiens 814 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392713&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389052 404961038 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573793 N#CCc1cnc(-c2ccc3OCCOc3c2)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C23H24N6O2/c24-10-8-18-15-26-22(16-6-7-19-20(14-16)31-13-12-30-19)29(18)21-9-11-25-23(28-21)27-17-4-2-1-3-5-17/h6-7,9,11,14-15,17H,1-5,8,12-13H2,(H,25,27,28) ORHHPSNLVCWQPB-UHFFFAOYSA-N 392714 Example 8::US10301291, Compound 11b Mitogen-activated protein kinase 10 Homo sapiens 6270 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392714&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389311 404961039 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573794 N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C24H23N7/c25-14-12-19-16-27-23(21-11-10-17-6-4-5-9-20(17)29-21)31(19)22-13-15-26-24(30-22)28-18-7-2-1-3-8-18/h4-6,9-11,13,15-16,18H,1-3,7-8,12H2,(H,26,28,30) YAYHNPYFBMMMLU-UHFFFAOYSA-N 392715 Example 9::US10301291, Compound 11c Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392715&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 130296606 404961040 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573795 N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C25H24N6/c26-14-12-22-17-28-24(20-11-10-18-6-4-5-7-19(18)16-20)31(22)23-13-15-27-25(30-23)29-21-8-2-1-3-9-21/h4-7,10-11,13,15-17,21H,1-3,8-9,12H2,(H,27,29,30) GJLZMTDDJPNXPU-UHFFFAOYSA-N 392716 Example 10::US10301291, Compound 11d Mitogen-activated protein kinase 10 Homo sapiens 142 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392716&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389213 404961041 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573796 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C21H20Cl2N6/c22-17-7-6-14(12-18(17)23)20-26-13-16(8-10-24)29(20)19-9-11-25-21(28-19)27-15-4-2-1-3-5-15/h6-7,9,11-13,15H,1-5,8H2,(H,25,27,28) LGWZSUMBRCSBJL-UHFFFAOYSA-N 392717 Example 11::US10301291, Compound 11e Mitogen-activated protein kinase 10 Homo sapiens 611 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392717&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 137452985 404961042 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573797 Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(NC2CCCCC2)n1 InChI=1S/C22H20F4N6/c23-18-7-6-14(12-17(18)22(24,25)26)20-29-13-16(8-10-27)32(20)19-9-11-28-21(31-19)30-15-4-2-1-3-5-15/h6-7,9,11-13,15H,1-5,8H2,(H,28,30,31) IIPOJSVNSFFFPM-UHFFFAOYSA-N 392718 Example 12::US10301291, Compound 11f Mitogen-activated protein kinase 10 Homo sapiens 10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392718&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 135389080 404961043 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573798 C[C@@H](O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCOc2c1 InChI=1S/C19H18N6O3/c1-12(26)9-23-19-21-7-5-17(24-19)25-14(4-6-20)10-22-18(25)13-2-3-15-16(8-13)28-11-27-15/h2-3,5,7-8,10,12,26H,4,9,11H2,1H3,(H,21,23,24)/t12-/m1/s1 KBMVXTJPDJPUCK-GFCCVEGCSA-N 50633044 CHEMBL5437442 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633044&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573799 C[C@@H](O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCCOc2c1 InChI=1S/C20H20N6O3/c1-13(27)11-24-20-22-7-5-18(25-20)26-15(4-6-21)12-23-19(26)14-2-3-16-17(10-14)29-9-8-28-16/h2-3,5,7,10,12-13,27H,4,8-9,11H2,1H3,(H,22,24,25)/t13-/m1/s1 BAHBVVGCFLNSRU-CYBMUJFWSA-N 50633045 CHEMBL5409831 Mitogen-activated protein kinase 10 Homo sapiens 9840 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633045&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573800 C[C@@H](O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2n1 InChI=1S/C21H19N7O/c1-14(29)12-25-21-23-11-9-19(27-21)28-16(8-10-22)13-24-20(28)18-7-6-15-4-2-3-5-17(15)26-18/h2-7,9,11,13-14,29H,8,12H2,1H3,(H,23,25,27)/t14-/m1/s1 MTLGSBMSYAUVFE-CQSZACIVSA-N 50633046 CHEMBL5395134 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633046&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573801 C[C@@H](O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1 InChI=1S/C22H20N6O/c1-15(29)13-26-22-24-11-9-20(27-22)28-19(8-10-23)14-25-21(28)18-7-6-16-4-2-3-5-17(16)12-18/h2-7,9,11-12,14-15,29H,8,13H2,1H3,(H,24,26,27)/t15-/m1/s1 DILISPNYIVRDBP-OAHLLOKOSA-N 50633047 CHEMBL5425080 Mitogen-activated protein kinase 10 Homo sapiens 4960 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633047&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573802 C[C@@H](O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc(Cl)c(Cl)c1 InChI=1S/C18H16Cl2N6O/c1-11(27)9-24-18-22-7-5-16(25-18)26-13(4-6-21)10-23-17(26)12-2-3-14(19)15(20)8-12/h2-3,5,7-8,10-11,27H,4,9H2,1H3,(H,22,24,25)/t11-/m1/s1 SSORSZACHCNXSJ-LLVKDONJSA-N 50633048 CHEMBL5405861 Mitogen-activated protein kinase 10 Homo sapiens 6760 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633048&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573803 C[C@@H](O)CNc1nccc(n1)-n1c(CC#N)cnc1-c1ccc(F)c(c1)C(F)(F)F InChI=1S/C19H16F4N6O/c1-11(30)9-27-18-25-7-5-16(28-18)29-13(4-6-24)10-26-17(29)12-2-3-15(20)14(8-12)19(21,22)23/h2-3,5,7-8,10-11,30H,4,9H2,1H3,(H,25,27,28)/t11-/m1/s1 GXHNDVQIVCWVNB-LLVKDONJSA-N 50633049 CHEMBL5439711 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633049&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573804 N#CCc1cnc(C2=CC3OCOC3C=C2)n1-c1ccnc(N[C@H]2CCCNC2)n1 InChI=1S/C21H23N7O2/c22-7-5-16-12-25-20(14-3-4-17-18(10-14)30-13-29-17)28(16)19-6-9-24-21(27-19)26-15-2-1-8-23-11-15/h3-4,6,9-10,12,15,17-18,23H,1-2,5,8,11,13H2,(H,24,26,27)/t15-,17?,18?/m0/s1 NUYGNIRJLNARPZ-ZLPCBKJTSA-N 50633050 CHEMBL5431761 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633050&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573805 N#CCc1cnc(C2=CC3OCCOC3C=C2)n1-c1ccnc(N[C@H]2CCCNC2)n1 InChI=1S/C22H25N7O2/c23-7-5-17-14-26-21(15-3-4-18-19(12-15)31-11-10-30-18)29(17)20-6-9-25-22(28-20)27-16-2-1-8-24-13-16/h3-4,6,9,12,14,16,18-19,24H,1-2,5,8,10-11,13H2,(H,25,27,28)/t16-,18?,19?/m0/s1 LVSDHHYPMVIKHK-IVMQYODDSA-N 50633051 CHEMBL5432802 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633051&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573806 N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(N[C@H]2CCCNC2)n1 InChI=1S/C23H22N8/c24-11-9-18-15-27-22(20-8-7-16-4-1-2-6-19(16)29-20)31(18)21-10-13-26-23(30-21)28-17-5-3-12-25-14-17/h1-2,4,6-8,10,13,15,17,25H,3,5,9,12,14H2,(H,26,28,30)/t17-/m0/s1 MANNUZLBILGUDA-KRWDZBQOSA-N 50633052 CHEMBL5434902 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633052&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573807 N#CCc1cnc(-c2ccc3ccccc3c2)n1-c1ccnc(N[C@H]2CCCNC2)n1 InChI=1S/C24H23N7/c25-11-9-21-16-28-23(19-8-7-17-4-1-2-5-18(17)14-19)31(21)22-10-13-27-24(30-22)29-20-6-3-12-26-15-20/h1-2,4-5,7-8,10,13-14,16,20,26H,3,6,9,12,15H2,(H,27,29,30)/t20-/m0/s1 PVAQJGAOCRZJQX-FQEVSTJZSA-N 50633053 CHEMBL5422325 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633053&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573808 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(N[C@H]2CCCNC2)n1 InChI=1S/C20H19Cl2N7/c21-16-4-3-13(10-17(16)22)19-26-12-15(5-7-23)29(19)18-6-9-25-20(28-18)27-14-2-1-8-24-11-14/h3-4,6,9-10,12,14,24H,1-2,5,8,11H2,(H,25,27,28)/t14-/m0/s1 KDDPNNXAZURUGP-AWEZNQCLSA-N 50633054 CHEMBL5397268 Mitogen-activated protein kinase 10 Homo sapiens 13300 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633054&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573809 O=C(C1CC1)N1CCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1C1=CC2OCOC2C=C1 InChI=1S/C25H27N7O3/c26-9-7-19-13-28-23(17-5-6-20-21(12-17)35-15-34-20)32(19)22-8-10-27-25(30-22)29-18-2-1-11-31(14-18)24(33)16-3-4-16/h5-6,8,10,12-13,16,18,20-21H,1-4,7,11,14-15H2,(H,27,29,30)/t18-,20?,21?/m0/s1 MJIKEHGGMHYXFN-PELRDEGISA-N 50633055 CHEMBL5439223 Mitogen-activated protein kinase 10 Homo sapiens 55 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633055&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573810 O=C(C1CC1)N1CCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1C1=CC2OCCOC2C=C1 InChI=1S/C26H29N7O3/c27-9-7-20-15-29-24(18-5-6-21-22(14-18)36-13-12-35-21)33(20)23-8-10-28-26(31-23)30-19-2-1-11-32(16-19)25(34)17-3-4-17/h5-6,8,10,14-15,17,19,21-22H,1-4,7,11-13,16H2,(H,28,30,31)/t19-,21?,22?/m0/s1 CCXKVTIVNJHHRW-KPQWGBOZSA-N 50633056 CHEMBL5396830 Mitogen-activated protein kinase 10 Homo sapiens 1520 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633056&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573811 O=C(C1CC1)N1CCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2n1 InChI=1S/C27H26N8O/c28-13-11-21-16-30-25(23-10-9-18-4-1-2-6-22(18)32-23)35(21)24-12-14-29-27(33-24)31-20-5-3-15-34(17-20)26(36)19-7-8-19/h1-2,4,6,9-10,12,14,16,19-20H,3,5,7-8,11,15,17H2,(H,29,31,33)/t20-/m0/s1 TXIPVVLKTCCGPA-FQEVSTJZSA-N 50633057 CHEMBL5429268 Mitogen-activated protein kinase 10 Homo sapiens 396 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633057&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573812 O=C(C1CC1)N1CCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1 InChI=1S/C28H27N7O/c29-13-11-24-17-31-26(22-10-7-19-4-1-2-5-21(19)16-22)35(24)25-12-14-30-28(33-25)32-23-6-3-15-34(18-23)27(36)20-8-9-20/h1-2,4-5,7,10,12,14,16-17,20,23H,3,6,8-9,11,15,18H2,(H,30,32,33)/t23-/m0/s1 MIFPZJRPCSILQA-QHCPKHFHSA-N 50621796 CHEMBL5396715 Mitogen-activated protein kinase 10 Homo sapiens 1.000000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621796&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573813 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C24H23Cl2N7O/c25-19-6-5-16(12-20(19)26)22-29-13-18(7-9-27)33(22)21-8-10-28-24(31-21)30-17-2-1-11-32(14-17)23(34)15-3-4-15/h5-6,8,10,12-13,15,17H,1-4,7,11,14H2,(H,28,30,31)/t17-/m0/s1 YHJXRSXZOCDBEA-KRWDZBQOSA-N 50633058 CHEMBL5418449 Mitogen-activated protein kinase 10 Homo sapiens 2.0 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633058&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573814 Fc1ccc(cc1C(F)(F)F)-c1ncc(CC#N)n1-c1ccnc(N[C@H]2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C25H23F4N7O/c26-20-6-5-16(12-19(20)25(27,28)29)22-32-13-18(7-9-30)36(22)21-8-10-31-24(34-21)33-17-2-1-11-35(14-17)23(37)15-3-4-15/h5-6,8,10,12-13,15,17H,1-4,7,11,14H2,(H,31,33,34)/t17-/m0/s1 AMJPALGZWXBOKQ-KRWDZBQOSA-N 50633059 CHEMBL5416681 Mitogen-activated protein kinase 10 Homo sapiens 3280 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633059&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573815 O=C(C1CC1)N1CCC[C@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1 InChI=1S/C28H27N7O/c29-13-11-24-17-31-26(22-10-7-19-4-1-2-5-21(19)16-22)35(24)25-12-14-30-28(33-25)32-23-6-3-15-34(18-23)27(36)20-8-9-20/h1-2,4-5,7,10,12,14,16-17,20,23H,3,6,8-9,11,15,18H2,(H,30,32,33)/t23-/m1/s1 MIFPZJRPCSILQA-HSZRJFAPSA-N 50633060 CHEMBL5394033 Mitogen-activated protein kinase 10 Homo sapiens 5.0 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633060&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573816 O=C(C1CC1)N1CCCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2ccccc2c1 InChI=1S/C29H29N7O/c30-14-12-25-18-32-27(23-11-8-20-5-1-2-6-22(20)17-23)36(25)26-13-15-31-29(34-26)33-24-7-3-4-16-35(19-24)28(37)21-9-10-21/h1-2,5-6,8,11,13,15,17-18,21,24H,3-4,7,9-10,12,16,19H2,(H,31,33,34)/t24-/m0/s1 QBROFJFJPQJMEQ-DEOSSOPVSA-N 50633061 CHEMBL5428554 Mitogen-activated protein kinase 10 Homo sapiens 24 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633061&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573817 O=C(C1CC1)N1CCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2occc2c1 InChI=1S/C26H25N7O2/c27-10-7-21-15-29-24(19-5-6-22-18(14-19)9-13-35-22)33(21)23-8-11-28-26(31-23)30-20-2-1-12-32(16-20)25(34)17-3-4-17/h5-6,8-9,11,13-15,17,20H,1-4,7,12,16H2,(H,28,30,31)/t20-/m0/s1 ZBEPMOZEXLGCTF-FQEVSTJZSA-N 50633062 CHEMBL5396572 Mitogen-activated protein kinase 10 Homo sapiens 6.2 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633062&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573818 O=C(C1CC1)N1CCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc2OCCc2c1 InChI=1S/C26H27N7O2/c27-10-7-21-15-29-24(19-5-6-22-18(14-19)9-13-35-22)33(21)23-8-11-28-26(31-23)30-20-2-1-12-32(16-20)25(34)17-3-4-17/h5-6,8,11,14-15,17,20H,1-4,7,9,12-13,16H2,(H,28,30,31)/t20-/m0/s1 FKBQOEJUXLTCGJ-FQEVSTJZSA-N 50633063 CHEMBL5405404 Mitogen-activated protein kinase 10 Homo sapiens 4.1 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633063&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573819 O=C(C1CC1)c1cccc(Nc2nccc(n2)-n2c(CC#N)cnc2-c2ccc3ccccc3c2)c1 InChI=1S/C29H22N6O/c30-14-12-25-18-32-28(23-11-8-19-4-1-2-5-21(19)16-23)35(25)26-13-15-31-29(34-26)33-24-7-3-6-22(17-24)27(36)20-9-10-20/h1-8,11,13,15-18,20H,9-10,12H2,(H,31,33,34) ZUYSNKSNKMMPMB-UHFFFAOYSA-N 50633064 CHEMBL5419748 Mitogen-activated protein kinase 10 Homo sapiens 7.0 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633064&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573820 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(NC(=O)NC2CCCN(C2)C(=O)C2CC2)n1 InChI=1S/C25H24Cl2N8O2/c26-19-6-5-16(12-20(19)27)22-30-13-18(7-9-28)35(22)21-8-10-29-24(32-21)33-25(37)31-17-2-1-11-34(14-17)23(36)15-3-4-15/h5-6,8,10,12-13,15,17H,1-4,7,11,14H2,(H2,29,31,32,33,37) ZJYJAQMNKQVMCP-UHFFFAOYSA-N 50633065 CHEMBL5413091 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633065&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573821 Clc1ccc(cc1Cl)-c1ncc(CC#N)n1-c1ccnc(N[C@H]2CCCN(C2)C(=O)NC2CC2)n1 InChI=1S/C24H24Cl2N8O/c25-19-6-3-15(12-20(19)26)22-29-13-18(7-9-27)34(22)21-8-10-28-23(32-21)30-17-2-1-11-33(14-17)24(35)31-16-4-5-16/h3,6,8,10,12-13,16-17H,1-2,4-5,7,11,14H2,(H,31,35)(H,28,30,32)/t17-/m0/s1 KVDDBBDCWPLOFR-KRWDZBQOSA-N 50633066 CHEMBL5436709 Mitogen-activated protein kinase 10 Homo sapiens 5.3 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633066&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573822 CC(C)(C)C(=O)N1CCC[C@@H](C1)Nc1nccc(n1)-n1c(CC#N)cnc1-c1ccc(Cl)c(Cl)c1 InChI=1S/C25H27Cl2N7O/c1-25(2,3)23(35)33-12-4-5-17(15-33)31-24-29-11-9-21(32-24)34-18(8-10-28)14-30-22(34)16-6-7-19(26)20(27)13-16/h6-7,9,11,13-14,17H,4-5,8,12,15H2,1-3H3,(H,29,31,32)/t17-/m0/s1 DNUIJDUIEIJBJM-KRWDZBQOSA-N 50633067 CHEMBL5403895 Mitogen-activated protein kinase 10 Homo sapiens 8.0 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50633067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50633067&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51573823 CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(N)c1C#N InChI=1S/C18H20N4O4/c1-4-26-18-13(10-19)14(20)9-16(22-18)21-17(23)8-11-7-12(24-2)5-6-15(11)25-3/h5-7,9H,4,8H2,1-3H3,(H3,20,21,22,23) KQMPRSZTUSSXND-UHFFFAOYSA-N 15908 Aminopyridine-Based Inhibitor 6o::N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide::aminopyridine deriv. 2 Mitogen-activated protein kinase 10 Homo sapiens 0.068000 ChEMBL 10.1016/j.ejmech.2022.114894 10.7270/Q2BK1HVC 36343411 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15908&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 11624601 46516179 5998 ZINC14959960 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51555354 O=C1C2=CC=CC3NN=C(C23)c2ccccc12 InChI=1S/C14H10N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,11-12,15H HJJSEANNATVFNW-UHFFFAOYSA-N 50625767 CHEMBL5439929 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1021/acs.jmedchem.3c00963 10.7270/Q2FR021H 38095579 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625767&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561262 FC(F)(Cl)C(=O)Nc1ccc2OCOc2c1 InChI=1S/C9H6ClF2NO3/c10-9(11,12)8(14)13-5-1-2-6-7(3-5)16-4-15-6/h1-3H,4H2,(H,13,14) OLDYQTOFYURHKF-UHFFFAOYSA-N 50627598 CHEMBL5400507 Mitogen-activated protein kinase 10 Homo sapiens >1000000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627598&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561263 FC(F)(Br)C(=O)Nc1ccc2OCOc2c1 InChI=1S/C9H6BrF2NO3/c10-9(11,12)8(14)13-5-1-2-6-7(3-5)16-4-15-6/h1-3H,4H2,(H,13,14) QREVGAHBRAJJGF-UHFFFAOYSA-N 50627589 CHEMBL5440414 Mitogen-activated protein kinase 10 Homo sapiens >1000000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627589&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561264 FC(F)(Cl)C(=O)c1cnc2ccccn12 InChI=1S/C9H5ClF2N2O/c10-9(11,12)8(15)6-5-13-7-3-1-2-4-14(6)7/h1-5H RYLULWDVNWTHMK-UHFFFAOYSA-N 50627590 CHEMBL5396542 Mitogen-activated protein kinase 10 Homo sapiens >1000000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627590&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561265 FC(F)(Cl)C(=O)Nc1nncs1 InChI=1S/C4H2ClF2N3OS/c5-4(6,7)2(11)9-3-10-8-1-12-3/h1H,(H,9,10,11) RLWAZGOAUFEECP-UHFFFAOYSA-N 50627591 CHEMBL5436338 Mitogen-activated protein kinase 10 Homo sapiens 243000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627591&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561266 FC(F)(Br)C(=O)Nc1nncs1 InChI=1S/C4H2BrF2N3OS/c5-4(6,7)2(11)9-3-10-8-1-12-3/h1H,(H,9,10,11) NLSBAVSUQVXADP-UHFFFAOYSA-N 50627592 CHEMBL5430996 Mitogen-activated protein kinase 10 Homo sapiens 248000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627592&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561267 FC(F)(I)C(=O)Nc1nncs1 InChI=1S/C4H2F2IN3OS/c5-4(6,7)2(11)9-3-10-8-1-12-3/h1H,(H,9,10,11) CKKABCXKEMPZHT-UHFFFAOYSA-N 50627593 CHEMBL5395254 Mitogen-activated protein kinase 10 Homo sapiens 186000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627593&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561268 FC(F)(Cl)C(=O)Nc1nnc(s1)-c1ccncc1 InChI=1S/C9H5ClF2N4OS/c10-9(11,12)7(17)14-8-16-15-6(18-8)5-1-3-13-4-2-5/h1-4H,(H,14,16,17) LGTPWTYCLIUZDG-UHFFFAOYSA-N 50627594 CHEMBL5424933 Mitogen-activated protein kinase 10 Homo sapiens 23000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627594&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561269 FC(F)(Br)C(=O)Nc1nnc(s1)-c1ccncc1 InChI=1S/C9H5BrF2N4OS/c10-9(11,12)7(17)14-8-16-15-6(18-8)5-1-3-13-4-2-5/h1-4H,(H,14,16,17) QJBZKGIEISLBPK-UHFFFAOYSA-N 50627595 CHEMBL5419704 Mitogen-activated protein kinase 10 Homo sapiens 17000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627595&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search SWM 8BZP 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561270 FC(F)(I)C(=O)Nc1nnc(s1)-c1ccncc1 InChI=1S/C9H5F2IN4OS/c10-9(11,12)7(17)14-8-16-15-6(18-8)5-1-3-13-4-2-5/h1-4H,(H,14,16,17) GHGXSDVJGRMPNW-UHFFFAOYSA-N 50627596 CHEMBL5423218 Mitogen-activated protein kinase 10 Homo sapiens 13000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627596&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51561271 FC(F)(Br)C(=O)Nc1nccs1 InChI=1S/C5H3BrF2N2OS/c6-5(7,8)3(11)10-4-9-1-2-12-4/h1-2H,(H,9,10,11) CZHBFJCXOUZRMD-UHFFFAOYSA-N 50627597 CHEMBL5410241 Mitogen-activated protein kinase 10 Homo sapiens >1000000 ChEMBL 10.1021/acs.jmedchem.3c00634 10.7270/Q22V2MKP 37487500 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50627597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50627597&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51565654 O=C1c2ccccc2-c2n[nH]c3cccc1c23 InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16) ACPOUJIDANTYHO-UHFFFAOYSA-N 16018 14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2(7),3,5,9(16),10,12-heptaen-8-one::CHEMBL7064::ChemBiol10705 Compound 4::JMC517015 Compound 2::SP 600125::SP-600125::SP600125::cid_8515::dibenzo[cd,g]indazol-6(2H)-one Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1016/j.ejmech.2023.115442 10.7270/Q27S7T7F 37156184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16018&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 537 2ZMD,4FEU,5LVL,1UKI,1PMV 8515 46509480 CHEMBL7064 DB01782 5273 ZINC04335977 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51565659 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)cc1 InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16,18-19H,17H2,1-2H3,(H,31,36)(H,32,37)(H,30,33,34)/b9-5+ RADRIIWGHYFWPP-WEVVVXLNSA-N 86632 JNK-IN-7 Mitogen-activated protein kinase 10 Homo sapiens 0.700000 ChEMBL 10.1016/j.ejmech.2023.115442 10.7270/Q27S7T7F 37156184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86632&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340685 136352681 ZINC87723492 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51565660 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Nc2nccc(n2)-c2cccnc2)c(C)c1 InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+ GJFCSAPFHAXMSF-UXBLZVDNSA-N 86633 JNK-IN-8 Mitogen-activated protein kinase 10 Homo sapiens 1.000000 ChEMBL 10.1016/j.ejmech.2023.115442 10.7270/Q27S7T7F 37156184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86633&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57340686 136352682 ZINC89464842 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51565663 N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1 InChI=1S/C20H16N6S/c21-12-15(19-25-17-5-1-2-6-18(17)27-19)16-8-11-24-20(26-16)23-10-7-14-4-3-9-22-13-14/h1-6,8-9,11,13,15H,7,10H2,(H,23,24,26) RCYPVQCPYKNSTG-UHFFFAOYSA-N 50169959 2-(benzo[d]thiazol-2(3H)-ylidene)-2-(2-(2-(pyridin-3-yl)ethylamino)pyrimidin-4-yl)acetonitrile::AS-601245::AS601245::CHEMBL1788116::CHEMBL191384::[3H-Benzothiazol-(2Z)-ylidene]-[2-(2-pyridin-3-yl-ethylamino)-pyrimidin-4-yl]-acetonitrile Mitogen-activated protein kinase 10 Homo sapiens 70 ChEMBL 10.1016/j.ejmech.2023.115442 10.7270/Q27S7T7F 37156184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169959&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search JN5 3CY3 10109823 104054707 CHEMBL1788116CHEMBL191384 5997 ZINC13647791 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51565677 CC(C)(C)CNc1ncc(Br)c(Nc2ccccc2C(N)=O)n1 InChI=1S/C16H20BrN5O/c1-16(2,3)9-20-15-19-8-11(17)14(22-15)21-12-7-5-4-6-10(12)13(18)23/h4-8H,9H2,1-3H3,(H2,18,23)(H2,19,20,21,22) HSEASLMARZYTKL-UHFFFAOYSA-N 50629538 CHEMBL5403766 Mitogen-activated protein kinase 10 Homo sapiens 33 ChEMBL 10.1016/j.ejmech.2023.115442 10.7270/Q27S7T7F 37156184 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50629538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50629538&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533294 FC(F)(F)c1cccc(c1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H24F3N5O2/c28-27(29,30)21-5-3-4-20(16-21)26(37)35-14-12-34(13-15-35)25(36)19-10-8-18(9-11-19)17-31-24-22-6-1-2-7-23(22)32-33-24/h1-11,16H,12-15,17H2,(H2,31,32,33) WMSBSYSDWXPOPA-UHFFFAOYSA-N 50616785 CHEMBL5423687 Mitogen-activated protein kinase 10 Homo sapiens 927 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616785&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533295 FC(F)(F)Oc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H24F3N5O3/c28-27(29,30)38-21-11-9-20(10-12-21)26(37)35-15-13-34(14-16-35)25(36)19-7-5-18(6-8-19)17-31-24-22-3-1-2-4-23(22)32-33-24/h1-12H,13-17H2,(H2,31,32,33) SKIFOJYEVRCUQM-UHFFFAOYSA-N 50616786 CHEMBL5428091 Mitogen-activated protein kinase 10 Homo sapiens 325 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616786&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533296 FC(F)(F)Oc1ccccc1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H24F3N5O3/c28-27(29,30)38-23-8-4-2-6-21(23)26(37)35-15-13-34(14-16-35)25(36)19-11-9-18(10-12-19)17-31-24-20-5-1-3-7-22(20)32-33-24/h1-12H,13-17H2,(H2,31,32,33) SMQPNHQJKKSXPI-UHFFFAOYSA-N 50616787 CHEMBL5441124 Mitogen-activated protein kinase 10 Homo sapiens 394 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616787&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533297 Fc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H24FN5O2/c27-21-11-9-20(10-12-21)26(34)32-15-13-31(14-16-32)25(33)19-7-5-18(6-8-19)17-28-24-22-3-1-2-4-23(22)29-30-24/h1-12H,13-17H2,(H2,28,29,30) KQJLZRGTGDJVEX-UHFFFAOYSA-N 50616788 CHEMBL5413820 Mitogen-activated protein kinase 10 Homo sapiens 3435 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616788&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533298 Fc1ccccc1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H24FN5O2/c27-22-7-3-1-5-20(22)26(34)32-15-13-31(14-16-32)25(33)19-11-9-18(10-12-19)17-28-24-21-6-2-4-8-23(21)29-30-24/h1-12H,13-17H2,(H2,28,29,30) GQQCWIUXTFMAMB-UHFFFAOYSA-N 50616789 CHEMBL5431122 Mitogen-activated protein kinase 10 Homo sapiens 615 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616789&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533299 Clc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H24ClN5O2/c27-21-11-9-20(10-12-21)26(34)32-15-13-31(14-16-32)25(33)19-7-5-18(6-8-19)17-28-24-22-3-1-2-4-23(22)29-30-24/h1-12H,13-17H2,(H2,28,29,30) FNIGCDUNZTWIER-UHFFFAOYSA-N 50616790 CHEMBL5413463 Mitogen-activated protein kinase 10 Homo sapiens 305 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616790&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533300 Clc1ccccc1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H24ClN5O2/c27-22-7-3-1-5-20(22)26(34)32-15-13-31(14-16-32)25(33)19-11-9-18(10-12-19)17-28-24-21-6-2-4-8-23(21)29-30-24/h1-12H,13-17H2,(H2,28,29,30) YXDDCQAOJIJVSR-UHFFFAOYSA-N 50616791 CHEMBL5415366 Mitogen-activated protein kinase 10 Homo sapiens 250 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616791&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533301 Brc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H24BrN5O2/c27-21-11-9-20(10-12-21)26(34)32-15-13-31(14-16-32)25(33)19-7-5-18(6-8-19)17-28-24-22-3-1-2-4-23(22)29-30-24/h1-12H,13-17H2,(H2,28,29,30) UPCWGTJPYHDONE-UHFFFAOYSA-N 50616792 CHEMBL5437251 Mitogen-activated protein kinase 10 Homo sapiens 315 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616792&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533302 Ic1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H24IN5O2/c27-21-11-9-20(10-12-21)26(34)32-15-13-31(14-16-32)25(33)19-7-5-18(6-8-19)17-28-24-22-3-1-2-4-23(22)29-30-24/h1-12H,13-17H2,(H2,28,29,30) KBBWQAVHMLMHLD-UHFFFAOYSA-N 50616793 CHEMBL5432722 Mitogen-activated protein kinase 10 Homo sapiens 903 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616793&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533303 Ic1ccccc1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H24IN5O2/c27-22-7-3-1-5-20(22)26(34)32-15-13-31(14-16-32)25(33)19-11-9-18(10-12-19)17-28-24-21-6-2-4-8-23(21)29-30-24/h1-12H,13-17H2,(H2,28,29,30) KTTWSSMXJLFPRO-UHFFFAOYSA-N 50616794 CHEMBL5437979 Mitogen-activated protein kinase 10 Homo sapiens 399 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616794&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533304 COc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H27N5O3/c1-35-22-12-10-21(11-13-22)27(34)32-16-14-31(15-17-32)26(33)20-8-6-19(7-9-20)18-28-25-23-4-2-3-5-24(23)29-30-25/h2-13H,14-18H2,1H3,(H2,28,29,30) OETUTKPEMSQCPX-UHFFFAOYSA-N 50616795 CHEMBL5408918 Mitogen-activated protein kinase 10 Homo sapiens 615 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616795&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533305 Fc1ccc(cc1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1)C(F)(F)F InChI=1S/C27H23F4N5O2/c28-22-10-9-19(27(29,30)31)15-21(22)26(38)36-13-11-35(12-14-36)25(37)18-7-5-17(6-8-18)16-32-24-20-3-1-2-4-23(20)33-34-24/h1-10,15H,11-14,16H2,(H2,32,33,34) CCMUJIWAGVVGIC-UHFFFAOYSA-N 50616796 CHEMBL5397012 Mitogen-activated protein kinase 10 Homo sapiens 358 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616796&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533306 FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C28H23F6N5O2/c29-27(30,31)20-13-19(14-21(15-20)28(32,33)34)26(41)39-11-9-38(10-12-39)25(40)18-7-5-17(6-8-18)16-35-24-22-3-1-2-4-23(22)36-37-24/h1-8,13-15H,9-12,16H2,(H2,35,36,37) KLKPEJVMWOZNHE-UHFFFAOYSA-N 50616797 CHEMBL5419083 Mitogen-activated protein kinase 10 Homo sapiens 295 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616797&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533307 FC(F)(F)c1ccc(C(=O)N2CCN(CC2)C(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)c(c1)C(F)(F)F InChI=1S/C28H23F6N5O2/c29-27(30,31)19-9-10-20(22(15-19)28(32,33)34)26(41)39-13-11-38(12-14-39)25(40)18-7-5-17(6-8-18)16-35-24-21-3-1-2-4-23(21)36-37-24/h1-10,15H,11-14,16H2,(H2,35,36,37) RQXOBEACGPLPRY-UHFFFAOYSA-N 50616798 CHEMBL5437584 Mitogen-activated protein kinase 10 Homo sapiens 253 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616798&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533308 Fc1ccc(C(=O)N2CCN(CC2)C(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)c(F)c1 InChI=1S/C26H23F2N5O2/c27-19-9-10-20(22(28)15-19)26(35)33-13-11-32(12-14-33)25(34)18-7-5-17(6-8-18)16-29-24-21-3-1-2-4-23(21)30-31-24/h1-10,15H,11-14,16H2,(H2,29,30,31) RJIMEPJVFAMBOJ-UHFFFAOYSA-N 50616799 CHEMBL5403120 Mitogen-activated protein kinase 10 Homo sapiens 639 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616799&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533309 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)c(Cl)c1 InChI=1S/C26H23Cl2N5O2/c27-19-9-10-20(22(28)15-19)26(35)33-13-11-32(12-14-33)25(34)18-7-5-17(6-8-18)16-29-24-21-3-1-2-4-23(21)30-31-24/h1-10,15H,11-14,16H2,(H2,29,30,31) YOTHJPUIPYRPFD-UHFFFAOYSA-N 50616800 CHEMBL5439566 Mitogen-activated protein kinase 10 Homo sapiens 153 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616800&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533310 Brc1ccc(C(=O)N2CCN(CC2)C(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)c(Br)c1 InChI=1S/C26H23Br2N5O2/c27-19-9-10-20(22(28)15-19)26(35)33-13-11-32(12-14-33)25(34)18-7-5-17(6-8-18)16-29-24-21-3-1-2-4-23(21)30-31-24/h1-10,15H,11-14,16H2,(H2,29,30,31) DRGFAWLVGCPPFJ-UHFFFAOYSA-N 50616801 CHEMBL5427329 Mitogen-activated protein kinase 10 Homo sapiens 248 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616801&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533311 Clc1cccc(Cl)c1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H23Cl2N5O2/c27-20-5-3-6-21(28)23(20)26(35)33-14-12-32(13-15-33)25(34)18-10-8-17(9-11-18)16-29-24-19-4-1-2-7-22(19)30-31-24/h1-11H,12-16H2,(H2,29,30,31) XMVNHIKDSPHXHN-UHFFFAOYSA-N 50616802 CHEMBL5425117 Mitogen-activated protein kinase 10 Homo sapiens 279 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616802&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533312 Clc1ccc(Cl)c(c1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H23Cl2N5O2/c27-19-9-10-22(28)21(15-19)26(35)33-13-11-32(12-14-33)25(34)18-7-5-17(6-8-18)16-29-24-20-3-1-2-4-23(20)30-31-24/h1-10,15H,11-14,16H2,(H2,29,30,31) NTJFLAXLULPZGW-UHFFFAOYSA-N 50616803 CHEMBL5405579 Mitogen-activated protein kinase 10 Homo sapiens 205 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616803&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533313 Fc1ccc(C(=O)N2CCN(CC2)C(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)c(Cl)c1 InChI=1S/C26H23ClFN5O2/c27-22-15-19(28)9-10-20(22)26(35)33-13-11-32(12-14-33)25(34)18-7-5-17(6-8-18)16-29-24-21-3-1-2-4-23(21)30-31-24/h1-10,15H,11-14,16H2,(H2,29,30,31) IFXXKSVBTLDWFT-UHFFFAOYSA-N 50616804 CHEMBL5438169 Mitogen-activated protein kinase 10 Homo sapiens 647 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616804&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533314 Fc1cccc(Cl)c1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H23ClFN5O2/c27-20-5-3-6-21(28)23(20)26(35)33-14-12-32(13-15-33)25(34)18-10-8-17(9-11-18)16-29-24-19-4-1-2-7-22(19)30-31-24/h1-11H,12-16H2,(H2,29,30,31) OAUJODNVYVGTTQ-UHFFFAOYSA-N 50616805 CHEMBL5434519 Mitogen-activated protein kinase 10 Homo sapiens 369 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616805&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533315 Fc1ccc(Cl)c(c1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H23ClFN5O2/c27-22-10-9-19(28)15-21(22)26(35)33-13-11-32(12-14-33)25(34)18-7-5-17(6-8-18)16-29-24-20-3-1-2-4-23(20)30-31-24/h1-10,15H,11-14,16H2,(H2,29,30,31) JKFNMNMCQLLOFP-UHFFFAOYSA-N 50616806 CHEMBL5432287 Mitogen-activated protein kinase 10 Homo sapiens 372 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616806&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533316 Fc1cccc(C(=O)N2CCN(CC2)C(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)c1Cl InChI=1S/C26H23ClFN5O2/c27-23-20(5-3-6-21(23)28)26(35)33-14-12-32(13-15-33)25(34)18-10-8-17(9-11-18)16-29-24-19-4-1-2-7-22(19)30-31-24/h1-11H,12-16H2,(H2,29,30,31) KOQCWERCYVNNMZ-UHFFFAOYSA-N 50616807 CHEMBL5441132 Mitogen-activated protein kinase 10 Homo sapiens 384 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616807&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533317 FC(F)(F)c1ccc(C(=O)N2CCN(CC2)C(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)c(Cl)c1 InChI=1S/C27H23ClF3N5O2/c28-22-15-19(27(29,30)31)9-10-20(22)26(38)36-13-11-35(12-14-36)25(37)18-7-5-17(6-8-18)16-32-24-21-3-1-2-4-23(21)33-34-24/h1-10,15H,11-14,16H2,(H2,32,33,34) CNSIUPYEQHVGRR-UHFFFAOYSA-N 50616808 CHEMBL5408361 Mitogen-activated protein kinase 10 Homo sapiens 239 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616808&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533318 FC(F)(F)c1cccc(Cl)c1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H23ClF3N5O2/c28-21-6-3-5-20(27(29,30)31)23(21)26(38)36-14-12-35(13-15-36)25(37)18-10-8-17(9-11-18)16-32-24-19-4-1-2-7-22(19)33-34-24/h1-11H,12-16H2,(H2,32,33,34) VRKFYQLAODZAOS-UHFFFAOYSA-N 50616809 CHEMBL5403784 Mitogen-activated protein kinase 10 Homo sapiens 253 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616809&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533319 FC(F)(F)c1ccc(Cl)c(c1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H23ClF3N5O2/c28-22-10-9-19(27(29,30)31)15-21(22)26(38)36-13-11-35(12-14-36)25(37)18-7-5-17(6-8-18)16-32-24-20-3-1-2-4-23(20)33-34-24/h1-10,15H,11-14,16H2,(H2,32,33,34) XDYWYBAEEPSNKN-UHFFFAOYSA-N 50616810 CHEMBL5434537 Mitogen-activated protein kinase 10 Homo sapiens 282 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616810&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533320 Cc1cccc(Cl)c1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H26ClN5O2/c1-18-5-4-7-22(28)24(18)27(35)33-15-13-32(14-16-33)26(34)20-11-9-19(10-12-20)17-29-25-21-6-2-3-8-23(21)30-31-25/h2-12H,13-17H2,1H3,(H2,29,30,31) PBPXAHDTNPOCTO-UHFFFAOYSA-N 50616811 CHEMBL5398682 Mitogen-activated protein kinase 10 Homo sapiens 597 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616811&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533321 Cc1ccc(Cl)c(c1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H26ClN5O2/c1-18-6-11-23(28)22(16-18)27(35)33-14-12-32(13-15-33)26(34)20-9-7-19(8-10-20)17-29-25-21-4-2-3-5-24(21)30-31-25/h2-11,16H,12-15,17H2,1H3,(H2,29,30,31) SXNXSYJPLDULBA-UHFFFAOYSA-N 50616812 CHEMBL5410441 Mitogen-activated protein kinase 10 Homo sapiens 589 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616812&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533322 COc1ccc(C(=O)N2CCN(CC2)C(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)c(Cl)c1 InChI=1S/C27H26ClN5O3/c1-36-20-10-11-21(23(28)16-20)27(35)33-14-12-32(13-15-33)26(34)19-8-6-18(7-9-19)17-29-25-22-4-2-3-5-24(22)30-31-25/h2-11,16H,12-15,17H2,1H3,(H2,29,30,31) FVZSQWNXOQJHRD-UHFFFAOYSA-N 50616813 CHEMBL5404265 Mitogen-activated protein kinase 10 Homo sapiens 668 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616813&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533323 Clc1ccccc1NC(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C26H25ClN6O2/c27-21-6-2-4-8-23(21)29-26(35)33-15-13-32(14-16-33)25(34)19-11-9-18(10-12-19)17-28-24-20-5-1-3-7-22(20)30-31-24/h1-12H,13-17H2,(H,29,35)(H2,28,30,31) LSOFLHQCDMMLMZ-UHFFFAOYSA-N 50616814 CHEMBL5439708 Mitogen-activated protein kinase 10 Homo sapiens 619 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616814&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533324 Cc1cc(Cl)ccc1NC(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H27ClN6O2/c1-18-16-21(28)10-11-23(18)30-27(36)34-14-12-33(13-15-34)26(35)20-8-6-19(7-9-20)17-29-25-22-4-2-3-5-24(22)31-32-25/h2-11,16H,12-15,17H2,1H3,(H,30,36)(H2,29,31,32) MJANGTUIFKVXII-UHFFFAOYSA-N 50616815 CHEMBL5411375 Mitogen-activated protein kinase 10 Homo sapiens 305 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616815&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533325 FC(F)(F)c1cc(NC(=O)N2CCN(CC2)C(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)cc(c1)C(F)(F)F InChI=1S/C28H24F6N6O2/c29-27(30,31)19-13-20(28(32,33)34)15-21(14-19)36-26(42)40-11-9-39(10-12-40)25(41)18-7-5-17(6-8-18)16-35-24-22-3-1-2-4-23(22)37-38-24/h1-8,13-15H,9-12,16H2,(H,36,42)(H2,35,37,38) MJGBRGSHGLPVGC-UHFFFAOYSA-N 50616816 CHEMBL5410780 Mitogen-activated protein kinase 10 Homo sapiens 8034 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616816&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533326 Clc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1cccc(CNc2n[nH]c3ccccc23)c1 InChI=1S/C26H24ClN5O2/c27-21-10-8-19(9-11-21)25(33)31-12-14-32(15-13-31)26(34)20-5-3-4-18(16-20)17-28-24-22-6-1-2-7-23(22)29-30-24/h1-11,16H,12-15,17H2,(H2,28,29,30) XLNVWSCPZSVIAA-UHFFFAOYSA-N 50616817 CHEMBL5428502 Mitogen-activated protein kinase 10 Homo sapiens 7501 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616817&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533327 Brc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1cccc(CNc2n[nH]c3ccccc23)c1 InChI=1S/C26H24BrN5O2/c27-21-10-8-19(9-11-21)25(33)31-12-14-32(15-13-31)26(34)20-5-3-4-18(16-20)17-28-24-22-6-1-2-7-23(22)29-30-24/h1-11,16H,12-15,17H2,(H2,28,29,30) RSZGRUMBBTYYRX-UHFFFAOYSA-N 50616818 CHEMBL5435391 Mitogen-activated protein kinase 10 Homo sapiens 4641 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616818&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533328 FC(F)(F)c1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1cccc(CNc2n[nH]c3ccccc23)c1 InChI=1S/C27H24F3N5O2/c28-27(29,30)21-10-8-19(9-11-21)25(36)34-12-14-35(15-13-34)26(37)20-5-3-4-18(16-20)17-31-24-22-6-1-2-7-23(22)32-33-24/h1-11,16H,12-15,17H2,(H2,31,32,33) WCQUWTXTZOPQFM-UHFFFAOYSA-N 50616819 CHEMBL5397816 Mitogen-activated protein kinase 10 Homo sapiens 7234 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616819&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533329 Fc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4ccccc34)c2)c(F)c1 InChI=1S/C26H23F2N5O2/c27-19-8-9-20(22(28)15-19)26(35)33-12-10-32(11-13-33)25(34)18-5-3-4-17(14-18)16-29-24-21-6-1-2-7-23(21)30-31-24/h1-9,14-15H,10-13,16H2,(H2,29,30,31) OHTSQSOQYWMGMU-UHFFFAOYSA-N 50616820 CHEMBL5436065 Mitogen-activated protein kinase 10 Homo sapiens 4403 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616820&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533330 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4ccccc34)c2)c(Cl)c1 InChI=1S/C26H23Cl2N5O2/c27-19-8-9-20(22(28)15-19)26(35)33-12-10-32(11-13-33)25(34)18-5-3-4-17(14-18)16-29-24-21-6-1-2-7-23(21)30-31-24/h1-9,14-15H,10-13,16H2,(H2,29,30,31) MZCCPKGFXCDFHS-UHFFFAOYSA-N 50616821 CHEMBL5402580 Mitogen-activated protein kinase 10 Homo sapiens 4028 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616821&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533331 Fc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4ccccc34)c2)c(Cl)c1 InChI=1S/C26H23ClFN5O2/c27-22-15-19(28)8-9-20(22)26(35)33-12-10-32(11-13-33)25(34)18-5-3-4-17(14-18)16-29-24-21-6-1-2-7-23(21)30-31-24/h1-9,14-15H,10-13,16H2,(H2,29,30,31) GKMWUZZXHNTHJN-UHFFFAOYSA-N 50616822 CHEMBL5414065 Mitogen-activated protein kinase 10 Homo sapiens 7788 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616822&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533332 Fc1cccc(Cl)c1C(=O)N1CCN(CC1)C(=O)c1cccc(CNc2n[nH]c3ccccc23)c1 InChI=1S/C26H23ClFN5O2/c27-20-8-4-9-21(28)23(20)26(35)33-13-11-32(12-14-33)25(34)18-6-3-5-17(15-18)16-29-24-19-7-1-2-10-22(19)30-31-24/h1-10,15H,11-14,16H2,(H2,29,30,31) PKFJQMMDRBHBBY-UHFFFAOYSA-N 50616823 CHEMBL5403866 Mitogen-activated protein kinase 10 Homo sapiens 4299 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616823&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533333 Fc1ccc(cc1C(=O)N1CCN(CC1)C(=O)c1cccc(CNc2n[nH]c3ccccc23)c1)C(F)(F)F InChI=1S/C27H23F4N5O2/c28-22-9-8-19(27(29,30)31)15-21(22)26(38)36-12-10-35(11-13-36)25(37)18-5-3-4-17(14-18)16-32-24-20-6-1-2-7-23(20)33-34-24/h1-9,14-15H,10-13,16H2,(H2,32,33,34) TYXRUUASBLANFA-UHFFFAOYSA-N 50616824 CHEMBL5439622 Mitogen-activated protein kinase 10 Homo sapiens 4465 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616824&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533334 FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCN(CC1)C(=O)c1cccc(CNc2n[nH]c3ccccc23)c1 InChI=1S/C28H23F6N5O2/c29-27(30,31)20-13-19(14-21(15-20)28(32,33)34)26(41)39-10-8-38(9-11-39)25(40)18-5-3-4-17(12-18)16-35-24-22-6-1-2-7-23(22)36-37-24/h1-7,12-15H,8-11,16H2,(H2,35,36,37) ZBJILMPGEWOIDA-UHFFFAOYSA-N 50616825 CHEMBL5407894 Mitogen-activated protein kinase 10 Homo sapiens 7244 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616825&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533335 Cn1nc(NCc2cccc(c2)C(=O)N2CCN(CC2)C(=O)c2ccc(Cl)cc2Cl)c2ccccc12 InChI=1S/C27H25Cl2N5O2/c1-32-24-8-3-2-7-22(24)25(31-32)30-17-18-5-4-6-19(15-18)26(35)33-11-13-34(14-12-33)27(36)21-10-9-20(28)16-23(21)29/h2-10,15-16H,11-14,17H2,1H3,(H,30,31) KXRBLQPDZJZWBX-UHFFFAOYSA-N 50616826 CHEMBL5421438 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616826&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533336 Cc1cccc2c(NCc3cccc(c3)C(=O)N3CCN(CC3)C(=O)c3ccc(Cl)cc3Cl)n[nH]c12 InChI=1S/C27H25Cl2N5O2/c1-17-4-2-7-22-24(17)31-32-25(22)30-16-18-5-3-6-19(14-18)26(35)33-10-12-34(13-11-33)27(36)21-9-8-20(28)15-23(21)29/h2-9,14-15H,10-13,16H2,1H3,(H2,30,31,32) USMQZGFJRJOXOJ-UHFFFAOYSA-N 50616827 CHEMBL5430452 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616827&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533337 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4cccc(Cl)c34)c2)c(Cl)c1 InChI=1S/C26H22Cl3N5O2/c27-18-7-8-19(21(29)14-18)26(36)34-11-9-33(10-12-34)25(35)17-4-1-3-16(13-17)15-30-24-23-20(28)5-2-6-22(23)31-32-24/h1-8,13-14H,9-12,15H2,(H2,30,31,32) ZECOHPFWGOCWLO-UHFFFAOYSA-N 50616828 CHEMBL5393904 Mitogen-activated protein kinase 10 Homo sapiens 85 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616828&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533338 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4ccc(Cl)cc34)c2)c(Cl)c1 InChI=1S/C26H22Cl3N5O2/c27-18-5-7-23-21(13-18)24(32-31-23)30-15-16-2-1-3-17(12-16)25(35)33-8-10-34(11-9-33)26(36)20-6-4-19(28)14-22(20)29/h1-7,12-14H,8-11,15H2,(H2,30,31,32) IBTCZBCHZHAGDF-UHFFFAOYSA-N 50616829 CHEMBL5398897 Mitogen-activated protein kinase 10 Homo sapiens 202 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616829&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533339 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4cc(Cl)ccc34)c2)c(Cl)c1 InChI=1S/C26H22Cl3N5O2/c27-18-4-6-20(22(29)13-18)26(36)34-10-8-33(9-11-34)25(35)17-3-1-2-16(12-17)15-30-24-21-7-5-19(28)14-23(21)31-32-24/h1-7,12-14H,8-11,15H2,(H2,30,31,32) YOVBTRPZOBDNKQ-UHFFFAOYSA-N 50616830 CHEMBL5411091 Mitogen-activated protein kinase 10 Homo sapiens 239 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616830&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533340 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4ccc(Br)cc34)c2)c(Cl)c1 InChI=1S/C26H22BrCl2N5O2/c27-18-4-7-23-21(13-18)24(32-31-23)30-15-16-2-1-3-17(12-16)25(35)33-8-10-34(11-9-33)26(36)20-6-5-19(28)14-22(20)29/h1-7,12-14H,8-11,15H2,(H2,30,31,32) CMCTUXOATJSCMW-UHFFFAOYSA-N 50616831 CHEMBL5432224 Mitogen-activated protein kinase 10 Homo sapiens 289 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616831&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533341 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4cc(Br)ccc34)c2)c(Cl)c1 InChI=1S/C26H22BrCl2N5O2/c27-18-4-6-21-23(13-18)31-32-24(21)30-15-16-2-1-3-17(12-16)25(35)33-8-10-34(11-9-33)26(36)20-7-5-19(28)14-22(20)29/h1-7,12-14H,8-11,15H2,(H2,30,31,32) FLQZFIPSOPQSBJ-UHFFFAOYSA-N 50616832 CHEMBL5434414 Mitogen-activated protein kinase 10 Homo sapiens 348 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616832&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533342 Fc1cccc2[nH]nc(NCc3cccc(c3)C(=O)N3CCN(CC3)C(=O)c3ccc(Cl)cc3Cl)c12 InChI=1S/C26H22Cl2FN5O2/c27-18-7-8-19(20(28)14-18)26(36)34-11-9-33(10-12-34)25(35)17-4-1-3-16(13-17)15-30-24-23-21(29)5-2-6-22(23)31-32-24/h1-8,13-14H,9-12,15H2,(H2,30,31,32) PXZCTWSWOQQVIZ-UHFFFAOYSA-N 50616833 CHEMBL5409834 Mitogen-activated protein kinase 10 Homo sapiens 189 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616833&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533343 Fc1ccc2c(NCc3cccc(c3)C(=O)N3CCN(CC3)C(=O)c3ccc(Cl)cc3Cl)n[nH]c2c1 InChI=1S/C26H22Cl2FN5O2/c27-18-4-6-20(22(28)13-18)26(36)34-10-8-33(9-11-34)25(35)17-3-1-2-16(12-17)15-30-24-21-7-5-19(29)14-23(21)31-32-24/h1-7,12-14H,8-11,15H2,(H2,30,31,32) YHVJCKVTHDFYBX-UHFFFAOYSA-N 50616834 CHEMBL5425539 Mitogen-activated protein kinase 10 Homo sapiens 142 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616834&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533344 Fc1ccc2c(NCc3cccc(c3)C(=O)N3CCN(CC3)C(=O)c3ccc(Cl)cc3Cl)n[nH]c2c1F InChI=1S/C26H21Cl2F2N5O2/c27-17-4-5-18(20(28)13-17)26(37)35-10-8-34(9-11-35)25(36)16-3-1-2-15(12-16)14-31-24-19-6-7-21(29)22(30)23(19)32-33-24/h1-7,12-13H,8-11,14H2,(H2,31,32,33) IOGSYIHQPWVGBW-UHFFFAOYSA-N 50616835 CHEMBL5433711 Mitogen-activated protein kinase 10 Homo sapiens 136 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616835&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533345 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4cccc(I)c34)c2)c(Cl)c1 InChI=1S/C26H22Cl2IN5O2/c27-18-7-8-19(20(28)14-18)26(36)34-11-9-33(10-12-34)25(35)17-4-1-3-16(13-17)15-30-24-23-21(29)5-2-6-22(23)31-32-24/h1-8,13-14H,9-12,15H2,(H2,30,31,32) ZJZIIHLMUAHIIA-UHFFFAOYSA-N 50616836 CHEMBL5436859 Mitogen-activated protein kinase 10 Homo sapiens 130 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616836&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533346 [O-][N+](=O)c1cc(Cl)c2[nH]nc(NCc3cccc(c3)C(=O)N3CCN(CC3)C(=O)c3ccc(Cl)cc3Cl)c2c1 InChI=1S/C26H21Cl3N6O4/c27-17-4-5-19(21(28)11-17)26(37)34-8-6-33(7-9-34)25(36)16-3-1-2-15(10-16)14-30-24-20-12-18(35(38)39)13-22(29)23(20)31-32-24/h1-5,10-13H,6-9,14H2,(H2,30,31,32) USOSQTLRHGHAMV-UHFFFAOYSA-N 50616837 CHEMBL5418432 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616837&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533347 Clc1ccc(C(=O)N2CCN(CC2)C(=O)c2cccc(CNc3n[nH]c4cccc(Cl)c34)c2)c(Cl)c1 InChI=1S/C26H22Cl3N5O2/c27-18-7-8-19(21(29)14-18)26(36)34-11-9-33(10-12-34)25(35)17-4-1-3-16(13-17)15-30-24-23-20(28)5-2-6-22(23)31-32-24/h1-8,13-14H,9-12,15H2,(H2,30,31,32) ZECOHPFWGOCWLO-UHFFFAOYSA-N 50616828 CHEMBL5393904 Mitogen-activated protein kinase 10 Homo sapiens 85 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616828&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533364 N#CC(c1nc2ccccc2s1)c1ccnc(OCc2ccc(CN3CCOCC3)cc2)n1 InChI=1S/C25H23N5O2S/c26-15-20(24-28-22-3-1-2-4-23(22)33-24)21-9-10-27-25(29-21)32-17-19-7-5-18(6-8-19)16-30-11-13-31-14-12-30/h1-10,20H,11-14,16-17H2 XCPPIJCBCWUBNT-UHFFFAOYSA-N 50601418 AS602801::As-602801::BENTAMAPIMOD::Bentamapimod::PGL-5001::PGL5001 Mitogen-activated protein kinase 10 Homo sapiens 230 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50601418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50601418&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10195250 482612270 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533365 O[C@H]1CC[C@@H](CC1)Nc1ncc2nc(Nc3c(F)cc(F)cc3F)n([C@H]3CCOC3)c2n1 InChI=1S/C21H23F3N6O2/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29)/t12-,13-,14-/m0/s1 IBGLGMOPHJQDJB-IHRRRGAJSA-N 50364378 CHEMBL1950289 Mitogen-activated protein kinase 10 Homo sapiens 6.0 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50364378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50364378&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search KBI 3TTI 11597537 136968440 CHEMBL1950289 ZINC35902440 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533366 Oc1c2cccc3[nH][nH]c(c23)c2ccccc12 InChI=1S/C14H10N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,15-17H BRKXAADNUXOTJZ-UHFFFAOYSA-N 50211302 5a,10c-Dihydro-2H-dibenzo[cd,g]indazol-6-one::CHEMBL252761 Mitogen-activated protein kinase 10 Homo sapiens 90 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211302&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10398628 104087500 CHEMBL252761 ZINC28966658 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533370 Cc1ccc(cn1)-c1ncn(n1)-c1ccc(Nc2nccc(n2)-c2cccc(c2)N2CCOCC2)cc1 InChI=1S/C28H26N8O/c1-20-5-6-22(18-30-20)27-31-19-36(34-27)24-9-7-23(8-10-24)32-28-29-12-11-26(33-28)21-3-2-4-25(17-21)35-13-15-37-16-14-35/h2-12,17-19H,13-16H2,1H3,(H,29,32,33) QDMXVKKPYBGIAS-UHFFFAOYSA-N 50059654 CHEMBL2144409 Mitogen-activated protein kinase 10 Homo sapiens 159 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059654&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 57519510 313070566 CHEMBL2144409 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51534156 C[C@H]1CN(C[C@H]1Nc1nccc(n1)-c1c(nn2ccccc12)-c1ccccc1)C(=O)c1ccc(NC(=O)\C=C\CN(C)C)cc1 InChI=1S/C35H36N8O2/c1-24-22-42(34(45)26-14-16-27(17-15-26)37-31(44)13-9-20-41(2)3)23-29(24)39-35-36-19-18-28(38-35)32-30-12-7-8-21-43(30)40-33(32)25-10-5-4-6-11-25/h4-19,21,24,29H,20,22-23H2,1-3H3,(H,37,44)(H,36,38,39)/b13-9+/t24-,29+/m0/s1 FVONQZQMUHLATI-PIAHHGHBSA-N 50617125 CHEMBL5398852 Mitogen-activated protein kinase 10 Homo sapiens 84 ChEMBL 10.1021/acs.jmedchem.2c01834 10.7270/Q2T72NSD 36826833 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50617125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50617125&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51537007 CCn1c(nc2cc(ccc12)C(=O)NC)-c1ccccc1-c1ccc(C)cc1C InChI=1S/C25H25N3O/c1-5-28-23-13-11-18(25(29)26-4)15-22(23)27-24(28)21-9-7-6-8-20(21)19-12-10-16(2)14-17(19)3/h6-15H,5H2,1-4H3,(H,26,29) AAUYSFKQQJKKDD-UHFFFAOYSA-N 50618278 CHEMBL4633869 Mitogen-activated protein kinase 10 Homo sapiens 1.2 ChEMBL 10.1016/j.ejmech.2022.115079 10.7270/Q2GF0ZWP 36669370 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50618278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50618278&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533279 O=C(Nc1ccccc1)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C21H18N4O/c26-21(23-17-6-2-1-3-7-17)16-12-10-15(11-13-16)14-22-20-18-8-4-5-9-19(18)24-25-20/h1-13H,14H2,(H,23,26)(H2,22,24,25) LUOKPFLAYVQTGF-UHFFFAOYSA-N 50616771 CHEMBL5425813 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616771&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533280 Clc1ccc(NC(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)cc1 InChI=1S/C21H17ClN4O/c22-16-9-11-17(12-10-16)24-21(27)15-7-5-14(6-8-15)13-23-20-18-3-1-2-4-19(18)25-26-20/h1-12H,13H2,(H,24,27)(H2,23,25,26) HUPMTHOUFSNQRJ-UHFFFAOYSA-N 50616772 CHEMBL5437801 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616772&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533281 COc1ccc(NC(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)cc1 InChI=1S/C22H20N4O2/c1-28-18-12-10-17(11-13-18)24-22(27)16-8-6-15(7-9-16)14-23-21-19-4-2-3-5-20(19)25-26-21/h2-13H,14H2,1H3,(H,24,27)(H2,23,25,26) CYOBQZYYRHOFJQ-UHFFFAOYSA-N 50616773 CHEMBL5426312 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616773&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533282 Cc1cc(NC(=O)c2ccc(CNc3n[nH]c4ccccc34)cc2)ccc1Cl InChI=1S/C22H19ClN4O/c1-14-12-17(10-11-19(14)23)25-22(28)16-8-6-15(7-9-16)13-24-21-18-4-2-3-5-20(18)26-27-21/h2-12H,13H2,1H3,(H,25,28)(H2,24,26,27) MTVRLNWLOAYTNN-UHFFFAOYSA-N 50616774 CHEMBL5416622 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616774&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533283 O=C(NN1CCCCC1)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C20H23N5O/c26-20(24-25-12-4-1-5-13-25)16-10-8-15(9-11-16)14-21-19-17-6-2-3-7-18(17)22-23-19/h2-3,6-11H,1,4-5,12-14H2,(H,24,26)(H2,21,22,23) JAUYTWRAVONHPV-UHFFFAOYSA-N 50616775 CHEMBL5410090 Mitogen-activated protein kinase 10 Homo sapiens 8970 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616775&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533284 O=C(NN1CCOCC1)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C19H21N5O2/c25-19(23-24-9-11-26-12-10-24)15-7-5-14(6-8-15)13-20-18-16-3-1-2-4-17(16)21-22-18/h1-8H,9-13H2,(H,23,25)(H2,20,21,22) BEDUACGTRWXVSQ-UHFFFAOYSA-N 50616776 CHEMBL5437898 Mitogen-activated protein kinase 10 Homo sapiens 7418 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616776&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533285 O=C(N1CCOCC1)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C19H20N4O2/c24-19(23-9-11-25-12-10-23)15-7-5-14(6-8-15)13-20-18-16-3-1-2-4-17(16)21-22-18/h1-8H,9-13H2,(H2,20,21,22) VSTFNYDDIQDCQW-UHFFFAOYSA-N 50616777 CHEMBL5436019 Mitogen-activated protein kinase 10 Homo sapiens 7691 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616777&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533286 O=C(N1CCCC1)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C19H20N4O/c24-19(23-11-3-4-12-23)15-9-7-14(8-10-15)13-20-18-16-5-1-2-6-17(16)21-22-18/h1-2,5-10H,3-4,11-13H2,(H2,20,21,22) XKIKDFIXLTWCTJ-UHFFFAOYSA-N 50616778 CHEMBL5433156 Mitogen-activated protein kinase 10 Homo sapiens 7512 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616778&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533287 O=C(N1CCN(CC1)C1CC1)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C22H25N5O/c28-22(27-13-11-26(12-14-27)18-9-10-18)17-7-5-16(6-8-17)15-23-21-19-3-1-2-4-20(19)24-25-21/h1-8,18H,9-15H2,(H2,23,24,25) YLDWFCDDMIXETM-UHFFFAOYSA-N 50616779 CHEMBL5431131 Mitogen-activated protein kinase 10 Homo sapiens 864 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616779&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533288 O=C(N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1)c1ccccc1 InChI=1S/C26H25N5O2/c32-25(20-6-2-1-3-7-20)30-14-16-31(17-15-30)26(33)21-12-10-19(11-13-21)18-27-24-22-8-4-5-9-23(22)28-29-24/h1-13H,14-18H2,(H2,27,28,29) PEAPUMUJMZNUAV-UHFFFAOYSA-N 50616780 CHEMBL5440610 Mitogen-activated protein kinase 10 Homo sapiens 614 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616780&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533289 O=C(NCCc1ccccc1)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C23H22N4O/c28-23(24-15-14-17-6-2-1-3-7-17)19-12-10-18(11-13-19)16-25-22-20-8-4-5-9-21(20)26-27-22/h1-13H,14-16H2,(H,24,28)(H2,25,26,27) QSONCQFXXZWSRA-UHFFFAOYSA-N 50616781 CHEMBL5401974 Mitogen-activated protein kinase 10 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616781&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533290 CN1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C20H23N5O/c1-24-10-12-25(13-11-24)20(26)16-8-6-15(7-9-16)14-21-19-17-4-2-3-5-18(17)22-23-19/h2-9H,10-14H2,1H3,(H2,21,22,23) NSIWBUXAHFTGLV-UHFFFAOYSA-N 50616782 CHEMBL5407304 Mitogen-activated protein kinase 10 Homo sapiens 892 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616782&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533291 Oc1c2cccc3[nH][nH]c(c23)c2ccccc12 InChI=1S/C14H10N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7,15-17H BRKXAADNUXOTJZ-UHFFFAOYSA-N 50211302 5a,10c-Dihydro-2H-dibenzo[cd,g]indazol-6-one::CHEMBL252761 Mitogen-activated protein kinase 10 Homo sapiens 87 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211302&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 10398628 104087500 CHEMBL252761 ZINC28966658 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533292 FC(F)(F)c1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H24F3N5O2/c28-27(29,30)21-11-9-20(10-12-21)26(37)35-15-13-34(14-16-35)25(36)19-7-5-18(6-8-19)17-31-24-22-3-1-2-4-23(22)32-33-24/h1-12H,13-17H2,(H2,31,32,33) ZMWPFJSKCJXGAB-UHFFFAOYSA-N 50616783 CHEMBL5405264 Mitogen-activated protein kinase 10 Homo sapiens 348 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616783&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1 51533293 FC(F)(F)c1ccccc1C(=O)N1CCN(CC1)C(=O)c1ccc(CNc2n[nH]c3ccccc23)cc1 InChI=1S/C27H24F3N5O2/c28-27(29,30)22-7-3-1-5-20(22)26(37)35-15-13-34(14-16-35)25(36)19-11-9-18(10-12-19)17-31-24-21-6-2-4-8-23(21)32-33-24/h1-12H,13-17H2,(H2,31,32,33) JAAQEHMAOLJNIX-UHFFFAOYSA-N 50616784 CHEMBL5432496 Mitogen-activated protein kinase 10 Homo sapiens 369 ChEMBL 10.1021/acs.jmedchem.2c01410 10.7270/Q2X352TH 36649216 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50616784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1653&target=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50616784&enzyme=Mitogen-activated+protein+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR 8ENJ,7YL1,7S1N,7KSK,7KSJ,7KSI,3TTJ,3TTI,1JNK,4WHZ,8WGF,8BZP,4Y5H,4Y46,4W4Y,4W4X,4W4W,4W4V,4U79,3V6S,3V6R,3KVX,3FI3,3DA6,2ZDU,2ZDT,2WAJ,2O2U,2O0U,4KKH,4KKG,4KKE,3G9N,3G9L,3G90,3CGO,3CGF,2P33,2OK1,3RTP,3PTG,4Z9L,1PMV,1PMU,1PMN,3OY1,3OXI,4H3B,4H39,4H36,2EXC,2R9S,2B1P,2XS0,6F5E,5LW1,3PZE,4IZY,4HYU,4HYS,4G1W,4E73,1UKI,1UKH,4YR8,2XRW,8X5M,3VUD Mitogen-activated protein kinase 10 MK10_HUMAN P53779 A6NFS3 A6NG28 B3KQ94 Q15707 Q49AP1