BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1400530 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1n[nH]c(=O)[nH]c1=O InChI=1S/C27H25Cl2N5O4/c28-20-2-1-3-21(29)22(20)24-19(25(38-33-24)16-4-5-16)14-37-18-10-12-34(13-11-18)17-8-6-15(7-9-17)23-26(35)30-27(36)32-31-23/h1-3,6-9,16,18H,4-5,10-14H2,(H2,30,32,35,36) VGCPGKGCHMDPSV-UHFFFAOYSA-N 665631 6-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione::US20240116912, Example 10 RNA-binding protein FXR1 [244-476] Homo sapiens 9.10 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665631&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902539 497615797 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400531 Cc1cc(ccc1-c1noc(=O)[nH]1)N1CCC(CC1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 InChI=1S/C27H26Cl2N4O4/c1-15-13-17(7-8-19(15)26-30-27(34)37-32-26)33-11-9-18(10-12-33)35-14-20-24(31-36-25(20)16-5-6-16)23-21(28)3-2-4-22(23)29/h2-4,7-8,13,16,18H,5-6,9-12,14H2,1H3,(H,30,32,34) FDQKPQYJCQBOMJ-UHFFFAOYSA-N 665632 3-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-2-methylphenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 11 RNA-binding protein FXR1 [244-476] Homo sapiens 21.9 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665632&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902540 497615798 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400532 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1n[nH]c(=O)o1 InChI=1S/C26H24Cl2N4O4/c27-20-2-1-3-21(28)22(20)23-19(24(36-31-23)15-4-5-15)14-34-18-10-12-32(13-11-18)17-8-6-16(7-9-17)25-29-30-26(33)35-25/h1-3,6-9,15,18H,4-5,10-14H2,(H,30,33) RZSNDHNBQQQESY-UHFFFAOYSA-N 665633 5-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,3,4-oxadiazol-2(3H)-one::US20240116912, Example 12 RNA-binding protein FXR1 [244-476] Homo sapiens 73.7 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665633&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566807 497615799 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400533 Fc1cc(ccc1-c1noc(=O)[nH]1)N1CCC(CC1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 InChI=1S/C26H23Cl2FN4O4/c27-19-2-1-3-20(28)22(19)23-18(24(36-31-23)14-4-5-14)13-35-16-8-10-33(11-9-16)15-6-7-17(21(29)12-15)25-30-26(34)37-32-25/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H,30,32,34) SZUTZPIRLJSLMT-UHFFFAOYSA-N 665634 3-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-2-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 13 RNA-binding protein FXR1 [244-476] Homo sapiens 3.50 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665634&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902541 497615800 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400534 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(-c2noc(=O)[nH]2)c(Cl)c1 InChI=1S/C26H23Cl3N4O4/c27-19-2-1-3-20(28)22(19)23-18(24(36-31-23)14-4-5-14)13-35-16-8-10-33(11-9-16)15-6-7-17(21(29)12-15)25-30-26(34)37-32-25/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H,30,32,34) PURFABARUHIOQE-UHFFFAOYSA-N 665635 3-(2-chloro-4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 14 RNA-binding protein FXR1 [244-476] Homo sapiens 8.50 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665635&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902542 497615801 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400535 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(C1)c1ccc(cc1)-c1noc(=O)[nH]1 665636 3-(4-(3-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)pyrrolidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 15 RNA-binding protein FXR1 [244-476] Homo sapiens 892 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665636&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902543 497615802 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400536 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1cc(=O)[nH]o1 InChI=1S/C27H25Cl2N3O4/c28-21-2-1-3-22(29)25(21)26-20(27(36-31-26)17-4-5-17)15-34-19-10-12-32(13-11-19)18-8-6-16(7-9-18)23-14-24(33)30-35-23/h1-3,6-9,14,17,19H,4-5,10-13,15H2,(H,30,33) MAXXEFRDXYUJCL-UHFFFAOYSA-N 665637 5-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)isoxazol-3(2H)-one::US20240116912, Example 16 RNA-binding protein FXR1 [244-476] Homo sapiens 24.0 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665637&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566699 497615803 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400537 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-n1ncc(=O)[nH]c1=O InChI=1S/C27H25Cl2N5O4/c28-21-2-1-3-22(29)24(21)25-20(26(38-32-25)16-4-5-16)15-37-19-10-12-33(13-11-19)17-6-8-18(9-7-17)34-27(36)31-23(35)14-30-34/h1-3,6-9,14,16,19H,4-5,10-13,15H2,(H,31,35,36) OVTXNXZXPHHAHI-UHFFFAOYSA-N 665638 2-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,2,4-triazine-3, 5(2H,4H)-dione::US20240116912, Example 17 RNA-binding protein FXR1 [244-476] Homo sapiens 6067 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665638&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902544 497615804 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400538 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCCN(CC1)c1ccc(cc1)-c1noc(=O)[nH]1 665639 3-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)azepan-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 18 RNA-binding protein FXR1 [244-476] Homo sapiens 2.90 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665639&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902545 497615805 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400539 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CN(C1)c1ccc(cc1)-c1noc(=O)[nH]1 InChI=1S/C24H20Cl2N4O4/c25-18-2-1-3-19(26)20(18)21-17(22(33-28-21)13-4-5-13)12-32-16-10-30(11-16)15-8-6-14(7-9-15)23-27-24(31)34-29-23/h1-3,6-9,13,16H,4-5,10-12H2,(H,27,29,31) GUVFORGJSBNIDC-UHFFFAOYSA-N 665640 3-(4-(3-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)azetidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 19 RNA-binding protein FXR1 [244-476] Homo sapiens 122 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665640&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902546 497615806 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400540 C[C@H]1C[C@@H](CCN1c1ccc(cc1)-c1noc(=O)[nH]1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 665641 3-(4-((2S,4R)-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-methylpiperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 20 RNA-binding protein FXR1 [244-476] Homo sapiens 114 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665641&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902547 497615807 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400541 C[C@@H]1C[C@H](CCN1c1ccc(cc1)-c1noc(=O)[nH]1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 665642 3-(4-((2R,4S)-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-methylpiperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 21 RNA-binding protein FXR1 [244-476] Homo sapiens 79.3 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665642&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902548 497615808 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400542 C[C@H]1C[C@H](CCN1c1ccc(cc1)-c1noc(=O)[nH]1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 665643 3-(4-((2S,4S)-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-methylpiperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 22 RNA-binding protein FXR1 [244-476] Homo sapiens 63.3 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665643&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902549 497615809 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400543 C[C@@H]1C[C@@H](CCN1c1ccc(cc1)-c1noc(=O)[nH]1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 665644 3-(4-((2R,4R)-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-methylpiperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 23 RNA-binding protein FXR1 [244-476] Homo sapiens 3.10 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665644&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902550 497615810 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400544 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-n1c(=O)[nH]nc(C#N)c1=O InChI=1S/C28H24Cl2N6O4/c29-21-2-1-3-22(30)24(21)25-20(26(40-34-25)16-4-5-16)15-39-19-10-12-35(13-11-19)17-6-8-18(9-7-17)36-27(37)23(14-31)32-33-28(36)38/h1-3,6-9,16,19H,4-5,10-13,15H2,(H,33,38) HQNYEYHXUZZABT-UHFFFAOYSA-N 665645 4-(4-(4-((5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4- yl)methoxy)piperidin-1-yl)phenyl)-3,5- dioxo-2,3,4,5-tetrahydro-1,2,4-triazine- 6-carbonitrile::US20240116912, Example 24 RNA-binding protein FXR1 [244-476] Homo sapiens 552 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665645&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902551 497615811 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400545 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-n1nc(C#N)c(=O)[nH]c1=O InChI=1S/C28H24Cl2N6O4/c29-21-2-1-3-22(30)24(21)25-20(26(40-34-25)16-4-5-16)15-39-19-10-12-35(13-11-19)17-6-8-18(9-7-17)36-28(38)32-27(37)23(14-31)33-36/h1-3,6-9,16,19H,4-5,10-13,15H2,(H,32,37,38) CGOCGJWYILJMMI-UHFFFAOYSA-N 665646 2-(4-(4-((5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4- yl)methoxy)piperidin-1-yl)phenyl)-3,5- dioxo-2,3,4,5-tetrahydro-1,2,4-triazine- 6-carbonitrile::US20240116912, Example 25 RNA-binding protein FXR1 [244-476] Homo sapiens 9.10 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665646&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902552 497615812 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400546 Fc1cccc(F)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1noc(=O)[nH]1 InChI=1S/C26H24F2N4O4/c27-20-2-1-3-21(28)22(20)23-19(24(35-30-23)15-4-5-15)14-34-18-10-12-32(13-11-18)17-8-6-16(7-9-17)25-29-26(33)36-31-25/h1-3,6-9,15,18H,4-5,10-14H2,(H,29,31,33) WGHULKPZVMZGLT-UHFFFAOYSA-N 665647 3-(4-(4-((5-cyclopropyl-3-(2,6- difluorophenyl)isoxazol-4- yl)methoxy)piperidin-1-yl)phenyl)- 1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 26 RNA-binding protein FXR1 [244-476] Homo sapiens 111 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665647&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902553 497615813 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400547 CCOc1cccc(F)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1noc(=O)[nH]1 InChI=1S/C28H29FN4O5/c1-2-35-23-5-3-4-22(29)24(23)25-21(26(37-31-25)17-6-7-17)16-36-20-12-14-33(15-13-20)19-10-8-18(9-11-19)27-30-28(34)38-32-27/h3-5,8-11,17,20H,2,6-7,12-16H2,1H3,(H,30,32,34) VITPRUSENBCRQP-UHFFFAOYSA-N 665648 3-(4-(4-((5-cyclopropyl-3-(2-ethoxy-6- fluorophenyl)isoxazol-4- yl)methoxy)piperidin-1-yl)phenyl)- 1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 27 RNA-binding protein FXR1 [244-476] Homo sapiens 227 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665648&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902554 497615814 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400548 COc1cccc(F)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1noc(=O)[nH]1 InChI=1S/C27H27FN4O5/c1-34-22-4-2-3-21(28)23(22)24-20(25(36-30-24)16-5-6-16)15-35-19-11-13-32(14-12-19)18-9-7-17(8-10-18)26-29-27(33)37-31-26/h2-4,7-10,16,19H,5-6,11-15H2,1H3,(H,29,31,33) AVYPINKXTZNOIU-UHFFFAOYSA-N 665649 3-(4-(4-((5-cyclopropyl-3-(2-fluoro-6- methoxyphenyl)isoxazol-4- yl)methoxy)piperidin-1-yl)phenyl)- 1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 28 RNA-binding protein FXR1 [244-476] Homo sapiens 150 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665649&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902555 497615815 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400549 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1nc(co1)-c1noc(=O)[nH]1 InChI=1S/C23H21Cl2N5O5/c24-15-2-1-3-16(25)18(15)19-14(20(34-28-19)12-4-5-12)10-32-13-6-8-30(9-7-13)22-26-17(11-33-22)21-27-23(31)35-29-21/h1-3,11-13H,4-10H2,(H,27,29,31) AOZVHVRKPWPEAS-UHFFFAOYSA-N 665650 3-(2-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)oxazol-4-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 29 RNA-binding protein FXR1 [244-476] Homo sapiens 231 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665650&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902556 497615816 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400550 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1csc(c1)-c1noc(=O)[nH]1 InChI=1S/C24H22Cl2N4O4S/c25-17-2-1-3-18(26)20(17)21-16(22(33-28-21)13-4-5-13)11-32-15-6-8-30(9-7-15)14-10-19(35-12-14)23-27-24(31)34-29-23/h1-3,10,12-13,15H,4-9,11H2,(H,27,29,31) ZVJUJDFTCRPQFP-UHFFFAOYSA-N 665651 3-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)thiophen-2-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 30 RNA-binding protein FXR1 [244-476] Homo sapiens 296 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665651&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902557 497615817 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400551 C[C@@H]1CN(CC[C@@H]1OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1)c1ccc(cc1)-c1noc(=O)[nH]1 665652 3-(4-((3R,4S)-4-((5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4- yl)methoxy)-3-methylpiperidin-1- yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 31 RNA-binding protein FXR1 [244-476] Homo sapiens 45.0 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665652&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902558 497615818 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400552 C[C@H]1CN(CC[C@H]1OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1)c1ccc(cc1)-c1noc(=O)[nH]1 665653 3-(4-((3S,4R)-4-((5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4- yl)methoxy)-3-methylpiperidin-1- yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 32 RNA-binding protein FXR1 [244-476] Homo sapiens 12.6 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665653&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902559 497615819 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400553 C[C@H]1CN(CC[C@@H]1OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1)c1ccc(cc1)-c1noc(=O)[nH]1 665654 3-(4-((3S,4S)-4-((5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4- yl)methoxy)-3-methylpiperidin-1- yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 33 RNA-binding protein FXR1 [244-476] Homo sapiens 142 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665654&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902560 497615820 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400554 C[C@@H]1CN(CC[C@H]1OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1)c1ccc(cc1)-c1noc(=O)[nH]1 665655 3-(4-((3R,4R)-4-((5-cyclopropyl-3- (2,6-dichlorophenyl)isoxazol-4- yl)methoxy)-3-methylpiperidin-1- yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 34 RNA-binding protein FXR1 [244-476] Homo sapiens 153 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665655&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902561 497615821 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400555 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(s1)-c1noc(=O)[nH]1 InChI=1S/C24H22Cl2N4O4S/c25-16-2-1-3-17(26)20(16)21-15(22(33-28-21)13-4-5-13)12-32-14-8-10-30(11-9-14)19-7-6-18(35-19)23-27-24(31)34-29-23/h1-3,6-7,13-14H,4-5,8-12H2,(H,27,29,31) IBNFFGOEIFCRTL-UHFFFAOYSA-N 665656 3-(5-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)thiophen-2-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 35 RNA-binding protein FXR1 [244-476] Homo sapiens 43.5 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665656&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902562 497615822 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400556 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1noc(=O)[nH]1 InChI=1S/C27H25F3N4O5/c28-27(29,30)37-22-4-2-1-3-20(22)23-21(24(38-32-23)16-5-6-16)15-36-19-11-13-34(14-12-19)18-9-7-17(8-10-18)25-31-26(35)39-33-25/h1-4,7-10,16,19H,5-6,11-15H2,(H,31,33,35) DPFJJVPFDCVGAN-UHFFFAOYSA-N 665657 3-(4-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 36 RNA-binding protein FXR1 [244-476] Homo sapiens 18.8 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665657&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902563 497615823 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400557 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cn1)-c1n[nH]c(=O)o1 InChI=1S/C25H23Cl2N5O4/c26-18-2-1-3-19(27)21(18)22-17(23(36-31-22)14-4-5-14)13-34-16-8-10-32(11-9-16)20-7-6-15(12-28-20)24-29-30-25(33)35-24/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H,30,33) AXNNQHZFZVRSJV-UHFFFAOYSA-N 665658 5-(6-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-3-yl)-1,3,4-oxadiazol-2(3H)-one::US20240116912, Example 37 RNA-binding protein FXR1 [244-476] Homo sapiens 49.4 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665658&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566662 497615824 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400558 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1cc(cs1)-c1noc(=O)[nH]1 InChI=1S/C24H22Cl2N4O4S/c25-17-2-1-3-18(26)20(17)21-16(22(33-28-21)13-4-5-13)11-32-15-6-8-30(9-7-15)19-10-14(12-35-19)23-27-24(31)34-29-23/h1-3,10,12-13,15H,4-9,11H2,(H,27,29,31) UURWNSVUOBAODZ-UHFFFAOYSA-N 665659 3-(5-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)thiophen-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 38 RNA-binding protein FXR1 [244-476] Homo sapiens 28.6 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665659&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902564 497615825 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400559 Fc1cc(ccc1N1CCC(CC1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1)-c1noc(=O)[nH]1 InChI=1S/C26H23Cl2FN4O4/c27-18-2-1-3-19(28)22(18)23-17(24(36-31-23)14-4-5-14)13-35-16-8-10-33(11-9-16)21-7-6-15(12-20(21)29)25-30-26(34)37-32-25/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H,30,32,34) GHPVMVBXDLJGGQ-UHFFFAOYSA-N 665660 3-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-3-fluorophenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 39 RNA-binding protein FXR1 [244-476] Homo sapiens 16.1 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665660&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902565 497615826 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400560 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(nc1)-c1n[nH]c(=O)o1 InChI=1S/C25H23Cl2N5O4/c26-18-2-1-3-19(27)21(18)22-17(23(36-31-22)14-4-5-14)13-34-16-8-10-32(11-9-16)15-6-7-20(28-12-15)24-29-30-25(33)35-24/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H,30,33) CORBMDRAWBJYLO-UHFFFAOYSA-N 665661 5-(5-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-2-yl)-1,3,4-oxadiazol-2(3H)-one::US20240116912, Example 40 RNA-binding protein FXR1 [244-476] Homo sapiens 76.0 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665661&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566661 497615827 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400561 Fc1cc(ccc1-c1n[nH]c(=O)[nH]c1=O)N1CCC(CC1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 InChI=1S/C27H24Cl2FN5O4/c28-19-2-1-3-20(29)22(19)23-18(25(39-34-23)14-4-5-14)13-38-16-8-10-35(11-9-16)15-6-7-17(21(30)12-15)24-26(36)31-27(37)33-32-24/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H2,31,33,36,37) JSBWPOVCEZGKMW-UHFFFAOYSA-N 665662 6-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-2-fluorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione::US20240116912, Example 41 RNA-binding protein FXR1 [244-476] Homo sapiens 58.4 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665662&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902566 497615828 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400562 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1cc(on1)-c1noc(=O)[nH]1 InChI=1S/C23H21Cl2N5O5/c24-15-2-1-3-16(25)19(15)20-14(21(34-28-20)12-4-5-12)11-32-13-6-8-30(9-7-13)18-10-17(33-27-18)22-26-23(31)35-29-22/h1-3,10,12-13H,4-9,11H2,(H,26,29,31) AXABLBLDSZVVQT-UHFFFAOYSA-N 665663 3-(3-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)isoxazol-5-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 42 RNA-binding protein FXR1 [244-476] Homo sapiens 139 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665663&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902567 497615829 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400563 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cn1)-c1n[nH]c(=O)[nH]c1=O InChI=1S/C26H24Cl2N6O4/c27-18-2-1-3-19(28)21(18)23-17(24(38-33-23)14-4-5-14)13-37-16-8-10-34(11-9-16)20-7-6-15(12-29-20)22-25(35)30-26(36)32-31-22/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H2,30,32,35,36) AMAUCSHHMGEUTN-UHFFFAOYSA-N 665664 6-(6-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-3-yl)-1,2,4-triazine-3, 5(2H,4H)-dione::US20240116912, Example 43 RNA-binding protein FXR1 [244-476] Homo sapiens 11.2 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665664&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902568 497615830 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400564 Clc1ccccc1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1noc(=O)[nH]1 InChI=1S/C26H25ClN4O4/c27-22-4-2-1-3-20(22)23-21(24(34-29-23)16-5-6-16)15-33-19-11-13-31(14-12-19)18-9-7-17(8-10-18)25-28-26(32)35-30-25/h1-4,7-10,16,19H,5-6,11-15H2,(H,28,30,32) UMYXAJFONPTXOV-UHFFFAOYSA-N 665665 3-(4-(4-((3-(2-chlorophenyl)-5-cyclopropylisoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 44 RNA-binding protein FXR1 [244-476] Homo sapiens 21.3 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665665&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902569 497615831 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400565 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1nc(n[nH]1)-c1noc(=O)[nH]1 InChI=1S/C22H21Cl2N7O4/c23-14-2-1-3-15(24)16(14)17-13(18(34-29-17)11-4-5-11)10-33-12-6-8-31(9-7-12)21-25-19(27-28-21)20-26-22(32)35-30-20/h1-3,11-12H,4-10H2,(H,25,27,28)(H,26,30,32) WCFORUILDDQCFE-UHFFFAOYSA-N 665666 3-(5-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1H-1,2,4-triazol-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 45 RNA-binding protein FXR1 [244-476] Homo sapiens 610 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665666&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902570 497615832 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400566 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(nc1)-c1n[nH]c(=O)[nH]c1=O InChI=1S/C26H24Cl2N6O4/c27-18-2-1-3-19(28)21(18)22-17(24(38-33-22)14-4-5-14)13-37-16-8-10-34(11-9-16)15-6-7-20(29-12-15)23-25(35)30-26(36)32-31-23/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H2,30,32,35,36) DCKSWSDGNMVUQY-UHFFFAOYSA-N 665667 6-(5-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-2-yl)-1,2,4-triazine-3, 5(2H,4H)-dione::US20240116912, Example 46 RNA-binding protein FXR1 [244-476] Homo sapiens 74.6 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665667&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902571 497615833 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400567 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1COC1CCCN(CC1)c1ccc(cc1)-c1noc(=O)[nH]1 665668 3-(4-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)azepan-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 47 RNA-binding protein FXR1 [244-476] Homo sapiens 3.70 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665668&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902572 497615834 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400568 Fc1cc(ccc1-c1n[nH]c(=O)o1)N1CCC(CC1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 InChI=1S/C26H23Cl2FN4O4/c27-19-2-1-3-20(28)22(19)23-18(24(37-32-23)14-4-5-14)13-35-16-8-10-33(11-9-16)15-6-7-17(21(29)12-15)25-30-31-26(34)36-25/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H,31,34) PXBRADODGVCPRN-UHFFFAOYSA-N 665669 5-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-2-fluorophenyl)-1,3,4-oxadiazol-2(3H)-one::US20240116912, Example 48 RNA-binding protein FXR1 [244-476] Homo sapiens 41.6 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665669&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566588 497615835 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400569 Fc1cccc(F)c1-c1noc(C2CC2)c1COC1CCCN(CC1)c1ccc(cc1)-c1noc(=O)[nH]1 665670 3-(4-(4-((5-cyclopropyl-3-(2,6-difluorophenyl)isoxazol-4-yl)methoxy)azepan-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 49 RNA-binding protein FXR1 [244-476] Homo sapiens 11.7 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665670&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902573 497615836 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400570 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc(cc1)-c1noc(=O)[nH]1 665671 3-(4-((1R,F,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 50 RNA-binding protein FXR1 [244-476] Homo sapiens 3.20 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665671&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902574 497615837 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400571 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1n[nH]c(=O)o1 InChI=1S/C27H25F3N4O5/c28-27(29,30)38-22-4-2-1-3-20(22)23-21(24(39-33-23)16-5-6-16)15-36-19-11-13-34(14-12-19)18-9-7-17(8-10-18)25-31-32-26(35)37-25/h1-4,7-10,16,19H,5-6,11-15H2,(H,32,35) NKHHFBDVLNHMQZ-UHFFFAOYSA-N 665672 5-(4-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,3,4-oxadiazol-2(3H)-one::US20240116912, Example 51 RNA-binding protein FXR1 [244-476] Homo sapiens 325 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665672&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566705 497615838 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400572 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1cc(=O)[nH]o1 InChI=1S/C28H26F3N3O5/c29-28(30,31)37-23-4-2-1-3-21(23)26-22(27(39-33-26)18-5-6-18)16-36-20-11-13-34(14-12-20)19-9-7-17(8-10-19)24-15-25(35)32-38-24/h1-4,7-10,15,18,20H,5-6,11-14,16H2,(H,32,35) XZLIABHJTOJOSF-UHFFFAOYSA-N 665673 5-(4-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)isoxazol-3(2H)-one::US20240116912, Example 52 RNA-binding protein FXR1 [244-476] Homo sapiens 143 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665673&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566686 497615839 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400573 FC1(F)CN(CCC1OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1)c1ccc(cc1)-c1noc(=O)[nH]1 665674 3-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-3,3-difluoropiperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 53 RNA-binding protein FXR1 [244-476] Homo sapiens 9.00 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665674&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902575 497615840 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400574 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1COC1CCN(CC1(F)F)c1ccc(cc1)-c1noc(=O)[nH]1 665675 3-(4-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-3,3-difluoropiperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 54 RNA-binding protein FXR1 [244-476] Homo sapiens 37.6 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665675&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902576 497615841 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400575 Fc1cccc(F)c1-c1noc(C2CC2)c1COC1CCN(CC1(F)F)c1ccc(cc1)-c1noc(=O)[nH]1 665676 3-(4-(4-((5-cyclopropyl-3-(2,6-difluorophenyl)isoxazol-4-yl)methoxy)-3,3-difluoropiperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 55 RNA-binding protein FXR1 [244-476] Homo sapiens 174 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665676&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902577 497615842 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400576 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1cnc(s1)-c1noc(=O)[nH]1 InChI=1S/C23H21Cl2N5O4S/c24-15-2-1-3-16(25)18(15)19-14(20(33-28-19)12-4-5-12)11-32-13-6-8-30(9-7-13)17-10-26-22(35-17)21-27-23(31)34-29-21/h1-3,10,12-13H,4-9,11H2,(H,27,29,31) VBPPFULYGPCZLP-UHFFFAOYSA-N 665677 3-(5-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)thiazol-2-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 56 RNA-binding protein FXR1 [244-476] Homo sapiens 43.1 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665677&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902578 497615843 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400577 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1n[nH]c(=O)[nH]c1=O InChI=1S/C28H26F3N5O5/c29-28(30,31)40-22-4-2-1-3-20(22)24-21(25(41-35-24)17-5-6-17)15-39-19-11-13-36(14-12-19)18-9-7-16(8-10-18)23-26(37)32-27(38)34-33-23/h1-4,7-10,17,19H,5-6,11-15H2,(H2,32,34,37,38) DZNALYHLWBCSHI-UHFFFAOYSA-N 665678 6-(4-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione::US20240116912, Example 57 RNA-binding protein FXR1 [244-476] Homo sapiens 84.7 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665678&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902579 497615844 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400578 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1cc([nH]n1)-c1noc(=O)[nH]1 InChI=1S/C23H22Cl2N6O4/c24-15-2-1-3-16(25)19(15)20-14(21(34-29-20)12-4-5-12)11-33-13-6-8-31(9-7-13)18-10-17(27-28-18)22-26-23(32)35-30-22/h1-3,10,12-13H,4-9,11H2,(H,27,28)(H,26,30,32) SIFZRWFGQRCGDK-UHFFFAOYSA-N 665679 3-(3-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 58 RNA-binding protein FXR1 [244-476] Homo sapiens 421 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665679&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902580 497615845 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400579 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cn1)-c1cc(=O)[nH]o1 InChI=1S/C26H24Cl2N4O4/c27-19-2-1-3-20(28)24(19)25-18(26(36-31-25)15-4-5-15)14-34-17-8-10-32(11-9-17)22-7-6-16(13-29-22)21-12-23(33)30-35-21/h1-3,6-7,12-13,15,17H,4-5,8-11,14H2,(H,30,33) CRRSNVMAWCFTOP-UHFFFAOYSA-N 665680 5-(6-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-3-yl)isoxazol-3(2H)-one::US20240116912, Example 59 RNA-binding protein FXR1 [244-476] Homo sapiens 17.9 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665680&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 167152080 497615846 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400580 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cn1)-c1cc(=O)[nH]o1 InChI=1S/C27H25F3N4O5/c28-27(29,30)37-21-4-2-1-3-19(21)25-20(26(39-33-25)16-5-6-16)15-36-18-9-11-34(12-10-18)23-8-7-17(14-31-23)22-13-24(35)32-38-22/h1-4,7-8,13-14,16,18H,5-6,9-12,15H2,(H,32,35) VVAUALOVFXRXNU-UHFFFAOYSA-N 665681 5-(6-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-3-yl)isoxazol-3(2H)-one::US20240116912, Example 60 RNA-binding protein FXR1 [244-476] Homo sapiens 104 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665681&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566655 497615847 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400581 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cn1)-c1n[nH]c(=O)o1 InChI=1S/C26H24F3N5O5/c27-26(28,29)38-20-4-2-1-3-18(20)22-19(23(39-33-22)15-5-6-15)14-36-17-9-11-34(12-10-17)21-8-7-16(13-30-21)24-31-32-25(35)37-24/h1-4,7-8,13,15,17H,5-6,9-12,14H2,(H,32,35) HDMZNDFSNMUDFF-UHFFFAOYSA-N 665682 5-(6-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-3-yl)-1,3,4-oxadiazol-2(3H)-one::US20240116912, Example 61 RNA-binding protein FXR1 [244-476] Homo sapiens 298 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665682&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566562 497615848 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400582 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-n1c(=O)cn[nH]c1=O InChI=1S/C27H25Cl2N5O4/c28-21-2-1-3-22(29)24(21)25-20(26(38-32-25)16-4-5-16)15-37-19-10-12-33(13-11-19)17-6-8-18(9-7-17)34-23(35)14-30-31-27(34)36/h1-3,6-9,14,16,19H,4-5,10-13,15H2,(H,31,36) PUGWGSRCEWHMSC-UHFFFAOYSA-N 665683 4-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,2,4-triazine-3, 5(2H,4H)-dione::US20240116912, Example 62 RNA-binding protein FXR1 [244-476] Homo sapiens 6348 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665683&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902581 497615849 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400583 Fc1cccc(F)c1-c1noc(C2CC2)c1COC1CCN(CC1(F)F)c1ccc(cn1)-c1noc(=O)[nH]1 665684 3-(6-(4-((5-cyclopropyl-3-(2,6-difluorophenyl)isoxazol-4-yl)methoxy)-3,3-difluoropiperidin-1-yl)pyridin-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 63 RNA-binding protein FXR1 [244-476] Homo sapiens 215 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665684&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902582 497615850 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400584 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1COC1CCN(CC1(F)F)c1ccc(cn1)-c1noc(=O)[nH]1 665685 3-(6-(4-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-3,3-difluoropiperidin-1-yl)pyridin-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 64 RNA-binding protein FXR1 [244-476] Homo sapiens 70.0 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665685&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902583 497615851 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400585 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc(cc1)-c1n[nH]c(=O)o1 665686 5-(4-((1R,3R,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1,3,4-oxadiazol-2(3H)-one::US20240116912, Example 65 RNA-binding protein FXR1 [244-476] Homo sapiens 22.1 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665686&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171420470 497615852 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400586 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc(cn1)-c1noc(=O)[nH]1 665687 3-(6-((1R,3r,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)pyridin-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 66 RNA-binding protein FXR1 [244-476] Homo sapiens 3.00 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665687&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902584 497615853 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400587 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc(cc1)-c1n[nH]c(=O)[nH]c1=O 665688 6-(4-((1R,3R,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione::US20240116912, Example 67 RNA-binding protein FXR1 [244-476] Homo sapiens 12.7 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665688&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902585 497615854 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400588 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc(cn1)-c1n[nH]c(=O)o1 665689 5-(6-((1R,3R,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)pyridin-3-yl)-1,3,4-oxadiazol-2(3H)-one::US20240116912, Example 68 RNA-binding protein FXR1 [244-476] Homo sapiens 26.4 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665689&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171420492 497615855 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400589 FC(F)(F)Oc1ccccc1-c1noc(C2CC2)c1CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1ccc(cn1)-c1cc(=O)[nH]o1 665690 5-(6-((1R,3R,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)pyridin-3-yl)isoxazol-3(2H)-one::US20240116912, Example 69 RNA-binding protein FXR1 [244-476] Homo sapiens 9.50 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665690&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171420472 497615856 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400590 Cn1nc(cc1-c1noc(=O)[nH]1)N1CCC(CC1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 InChI=1S/C24H24Cl2N6O4/c1-31-18(23-27-24(33)36-30-23)11-19(28-31)32-9-7-14(8-10-32)34-12-15-21(29-35-22(15)13-5-6-13)20-16(25)3-2-4-17(20)26/h2-4,11,13-14H,5-10,12H2,1H3,(H,27,30,33) RMYKPSSUQWJVLJ-UHFFFAOYSA-N 665691 3-(3-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-pyrazol-5-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 70 RNA-binding protein FXR1 [244-476] Homo sapiens 233 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665691&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902586 497615857 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400591 C[C@@H]1C[C@@H](CCN1c1ccc(cn1)-c1noc(=O)[nH]1)OCc1c(onc1-c1c(Cl)cccc1Cl)C1CC1 665692 3-(6-((2R,4R)-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-methylpiperidin-1-yl)pyridin-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 71 RNA-binding protein FXR1 [244-476] Homo sapiens 2.10 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665692&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902587 497615858 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400592 C[C@@H]1C[C@@H](CCN1c1ccc(cn1)-c1noc(=O)[nH]1)OCc1c(onc1-c1ccccc1Cl)C1CC1 665693 3-(6-((2R,4R)-4-((3-(2-chlorophenyl)-5-cyclopropylisoxazol-4-yl)methoxy)-2-methylpiperidin-1-yl)pyridin-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 72 RNA-binding protein FXR1 [244-476] Homo sapiens 4.50 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665693&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902588 497615859 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400593 C[C@@H]1C[C@@H](CCN1c1ccc(cn1)-c1noc(=O)[nH]1)OCc1c(onc1-c1c(F)cccc1F)C1CC1 665694 3-(6-((2R,4R)-4-((5-cyclopropyl-3-(2,6-difluorophenyl)isoxazol-4-yl)methoxy)-2-methylpiperidin-1-yl)pyridin-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 73 RNA-binding protein FXR1 [244-476] Homo sapiens 47.6 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665694&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902589 497615860 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400594 Fc1cccc(F)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cn1)-c1noc(=O)[nH]1 InChI=1S/C25H23F2N5O4/c26-18-2-1-3-19(27)21(18)22-17(23(35-30-22)14-4-5-14)13-34-16-8-10-32(11-9-16)20-7-6-15(12-28-20)24-29-25(33)36-31-24/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H,29,31,33) LZORJYAULDARGP-UHFFFAOYSA-N 665695 3-(6-(4-((5-cyclopropyl-3-(2,6-difluorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 74 RNA-binding protein FXR1 [244-476] Homo sapiens 107 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665695&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902590 497615861 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400521 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)C(=O)c1noc(=O)[nH]1 InChI=1S/C21H20Cl2N4O5/c22-14-2-1-3-15(23)16(14)17-13(18(31-25-17)11-4-5-11)10-30-12-6-8-27(9-7-12)20(28)19-24-21(29)32-26-19/h1-3,11-12H,4-10H2,(H,24,26,29) RUJJJOUHGMTUGW-UHFFFAOYSA-N 665622 3-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidine-1-carbonyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 1 RNA-binding protein FXR1 [244-476] Homo sapiens 3184 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665622&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902531 497615788 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400522 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)C1=NN1 InChI=1S/C25H24Cl2N4O2/c26-20-2-1-3-21(27)22(20)23-19(24(33-30-23)15-4-5-15)14-32-18-10-12-31(13-11-18)17-8-6-16(7-9-17)25-28-29-25/h1-3,6-9,15,18H,4-5,10-14H2,(H,28,29) RWILOPMEHSRDHC-UHFFFAOYSA-N 665623 4-(((1-(4-(1H-diazirin-3-yl)phenyl)piperidin-4-yl)oxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole::US20240116912, Example 2 RNA-binding protein FXR1 [244-476] Homo sapiens 2885 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665623&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 164566703 497615789 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400523 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cc1)-c1noc(=O)[nH]1 InChI=1S/C26H24Cl2N4O4/c27-20-2-1-3-21(28)22(20)23-19(24(35-30-23)15-4-5-15)14-34-18-10-12-32(13-11-18)17-8-6-16(7-9-17)25-29-26(33)36-31-25/h1-3,6-9,15,18H,4-5,10-14H2,(H,29,31,33) DKLAMHSJRAFGNM-UHFFFAOYSA-N 665624 3-(4-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 3 RNA-binding protein FXR1 [244-476] Homo sapiens 3.60 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665624&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902532 497615790 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400524 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cn1)-n1c(=O)cn[nH]c1=O InChI=1S/C26H24Cl2N6O4/c27-19-2-1-3-20(28)23(19)24-18(25(38-32-24)15-4-5-15)14-37-17-8-10-33(11-9-17)21-7-6-16(12-29-21)34-22(35)13-30-31-26(34)36/h1-3,6-7,12-13,15,17H,4-5,8-11,14H2,(H,31,36) UCXFCKVQGZGZQN-UHFFFAOYSA-N 665625 4-(6-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-3-yl)-1,2,4-triazine-3, 5(2H,4H)-dione::US20240116912, Example 4 RNA-binding protein FXR1 [244-476] Homo sapiens 220 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665625&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902533 497615791 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400525 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ncc(cn1)-c1noc(=O)[nH]1 InChI=1S/C24H22Cl2N6O4/c25-17-2-1-3-18(26)19(17)20-16(21(35-30-20)13-4-5-13)12-34-15-6-8-32(9-7-15)23-27-10-14(11-28-23)22-29-24(33)36-31-22/h1-3,10-11,13,15H,4-9,12H2,(H,29,31,33) BNOCUBYTUXPQBL-UHFFFAOYSA-N 665626 3-(2-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyrimidin-5-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 5 RNA-binding protein FXR1 [244-476] Homo sapiens 31.0 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665626&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902534 497615792 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400526 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(cn1)-c1noc(=O)[nH]1 InChI=1S/C25H23Cl2N5O4/c26-18-2-1-3-19(27)21(18)22-17(23(35-30-22)14-4-5-14)13-34-16-8-10-32(11-9-16)20-7-6-15(12-28-20)24-29-25(33)36-31-24/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H,29,31,33) PCCAYOJLQWEMQA-UHFFFAOYSA-N 665627 3-(6-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-3-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 6 RNA-binding protein FXR1 [244-476] Homo sapiens 4.40 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665627&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902535 497615793 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400527 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1cccc(c1)-c1noc(=O)[nH]1 InChI=1S/C26H24Cl2N4O4/c27-20-5-2-6-21(28)22(20)23-19(24(35-30-23)15-7-8-15)14-34-18-9-11-32(12-10-18)17-4-1-3-16(13-17)25-29-26(33)36-31-25/h1-6,13,15,18H,7-12,14H2,(H,29,31,33) BUPROQYFCLKBTG-UHFFFAOYSA-N 665628 3-(3-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 7 RNA-binding protein FXR1 [244-476] Homo sapiens 105 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665628&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902536 497615794 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400528 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1cnc(nc1)-c1noc(=O)[nH]1 InChI=1S/C24H22Cl2N6O4/c25-17-2-1-3-18(26)19(17)20-16(21(35-30-20)13-4-5-13)12-34-15-6-8-32(9-7-15)14-10-27-22(28-11-14)23-29-24(33)36-31-23/h1-3,10-11,13,15H,4-9,12H2,(H,29,31,33) NAJSEBBGFSFCIA-UHFFFAOYSA-N 665629 3-(5-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyrimidin-2-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 8 RNA-binding protein FXR1 [244-476] Homo sapiens 28.1 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665629&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902537 497615795 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ 1400529 Clc1cccc(Cl)c1-c1noc(C2CC2)c1COC1CCN(CC1)c1ccc(nc1)-c1noc(=O)[nH]1 InChI=1S/C25H23Cl2N5O4/c26-18-2-1-3-19(27)21(18)22-17(23(35-30-22)14-4-5-14)13-34-16-8-10-32(11-9-16)15-6-7-20(28-12-15)24-29-25(33)36-31-24/h1-3,6-7,12,14,16H,4-5,8-11,13H2,(H,29,31,33) SZRWGMHOBDOUTB-UHFFFAOYSA-N 665630 3-(5-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)pyridin-2-yl)-1,2,4-oxadiazol-5(4H)-one::US20240116912, Example 9 RNA-binding protein FXR1 [244-476] Homo sapiens 175 US Patent 10.7270/Q23X8BX4 US20240116912 XU, Y; KLUCHER, K; ROMERO, FA Terns Pharmaceuticals, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=665630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1567&target=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=665630&enzyme=RNA-binding+protein+FXR1+%5B244-476%5D&column=ki&startPg=0&Increment=50&submit=Search 171902538 497615796 1 ARKVPGVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIGKNGKVIQEIVDKSGVVRVRIEGDNENKLPREDGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQIGSRSYSGRGRGRRGPNYTSGYGTNSELSNPSETESERKDELSDWSLAGEDDRDSRHQRDSRRRPGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNP 2CPQ