BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID of Ligand	PubChem SID of Ligand	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence	PDB ID(s) of Target Chain	UniProt (SwissProt) Recommended Name of Target Chain	UniProt (SwissProt) Entry Name of Target Chain	UniProt (SwissProt) Primary ID of Target Chain	UniProt (SwissProt) Secondary ID(s) of Target Chain	UniProt (SwissProt) Alternative ID(s) of Target Chain	UniProt (TrEMBL) Submitted Name of Target Chain	UniProt (TrEMBL) Entry Name of Target Chain	UniProt (TrEMBL) Primary ID of Target Chain	UniProt (TrEMBL) Secondary ID(s) of Target Chain	UniProt (TrEMBL) Alternative ID(s) of Target Chain
26297	CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1	InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)	BNRNXUUZRGQAQC-UHFFFAOYSA-N	14390	5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL192::SILDENAFIL CITRATE::Sildenafil::Sildenafil#::US11155558, Compound sildenafil::US11242347, Compound sildenafil::Viagra	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Canis lupus dingo		 33					7.4	30.00 C	Curated from the literature by BindingDB	10.1021/jm060113e	10.7270/Q2C24TP4	16759100	aid1797217		Allerton, CM; Barber, CG; Beaumont, KC; Brown, DG; Cole, SM; Ellis, D; Lane, CA; Maw, GN; Mount, NM; Rawson, DJ; Robinson, CM; Street, SD; Summerhill, NW	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14390	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1540&target=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14390&enzyme=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search	VIA	1XOS,3JWQ,2H42,1UDT,1TBF	5212	46514731	9139	CHEMBL192		4743	C07259	ZINC19796168	1	MNLEPPKAEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII	1FQJ	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	CNRG_CANLF	P54827							
26298	CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1	InChI=1S/C27H34N8O5S/c1-4-22-23-24(32-35(22)18-19-8-6-7-9-28-19)26(36)31-25(30-23)21-16-20(17-29-27(21)40-15-14-39-3)41(37,38)34-12-10-33(5-2)11-13-34/h6-9,16-17H,4-5,10-15,18H2,1-3H3,(H,30,31,36)	QDPNAMRLQRQPMR-UHFFFAOYSA-N	14392	3-ethyl-5-{5-[(4-ethylpiperazine-1-)sulfonyl]-2-(2-methoxyethoxy)pyridin-3-yl}-2-(pyridin-2-ylmethyl)-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::CHEMBL209157::Sildenafil Pyridyl Methyl Analogue 1	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Canis lupus dingo		 386					7.4	30.00 C	Curated from the literature by BindingDB	10.1021/jm060113e	10.7270/Q2C24TP4	16759100	aid1797217		Allerton, CM; Barber, CG; Beaumont, KC; Brown, DG; Cole, SM; Ellis, D; Lane, CA; Maw, GN; Mount, NM; Rawson, DJ; Robinson, CM; Street, SD; Summerhill, NW	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14392	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1540&target=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14392&enzyme=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search			9918515	46514732		CHEMBL209157				ZINC14955534	1	MNLEPPKAEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII	1FQJ	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	CNRG_CANLF	P54827							
26299	CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(CC)C1)C(C)=O	InChI=1S/C23H30N6O3/c1-5-8-9-32-23-17(10-15(11-24-23)14(4)30)21-25-19-18(6-2)29(16-12-28(7-3)13-16)27-20(19)22(31)26-21/h10-11,16H,5-9,12-13H2,1-4H3,(H,25,26,31)	INLBUQIADGPECI-UHFFFAOYSA-N	14393	5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(1-ethylazetidin-3-yl)-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::5-(5-Acetyl-2-butoxy-3-pyridinyl)-3-ethyl-2-(1-ethyl-3-azetidinyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 2	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Canis lupus dingo		 840					7.4	30.00 C	Curated from the literature by BindingDB	10.1021/jm060113e	10.7270/Q2C24TP4	16759100	aid1797217		Allerton, CM; Barber, CG; Beaumont, KC; Brown, DG; Cole, SM; Ellis, D; Lane, CA; Maw, GN; Mount, NM; Rawson, DJ; Robinson, CM; Street, SD; Summerhill, NW	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14393	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1540&target=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14393&enzyme=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search		2CHM	9845992	46514733						ZINC14955538	1	MNLEPPKAEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII	1FQJ	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	CNRG_CANLF	P54827							
26300	CCCCOc1ncc(cc1-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1)C(C)=O	InChI=1S/C24H26N6O3/c1-4-6-11-33-24-18(12-16(13-26-24)15(3)31)22-27-20-19(5-2)30(29-21(20)23(32)28-22)14-17-9-7-8-10-25-17/h7-10,12-13H,4-6,11,14H2,1-3H3,(H,27,28,32)	ZXUXLNXJLINUPY-UHFFFAOYSA-N	14394	5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(pyridin-2-ylmethyl)-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::5-(5-Acetyl-2-butoxy-3-pyridinyl)-3-ethyl-2-(2-pyridinylmethyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 9	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Canis lupus dingo		 183					7.4	30.00 C	Curated from the literature by BindingDB	10.1021/jm060113e	10.7270/Q2C24TP4	16759100	aid1797217		Allerton, CM; Barber, CG; Beaumont, KC; Brown, DG; Cole, SM; Ellis, D; Lane, CA; Maw, GN; Mount, NM; Rawson, DJ; Robinson, CM; Street, SD; Summerhill, NW	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14394	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1540&target=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14394&enzyme=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search			11633708	46514734						ZINC14955543	1	MNLEPPKAEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII	1FQJ	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	CNRG_CANLF	P54827							
26301	CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(CC)C1)C(C)O	InChI=1S/C23H32N6O3/c1-5-8-9-32-23-17(10-15(11-24-23)14(4)30)21-25-19-18(6-2)29(16-12-28(7-3)13-16)27-20(19)22(31)26-21/h10-11,14,16,30H,5-9,12-13H2,1-4H3,(H,25,26,31)	RLMYIBANPYJYTP-UHFFFAOYSA-N	14395	5-[2-Butoxy-5-(1-hydroxyethyl)-3-pyridinyl]-3-ethyl-2-(1-ethyl-3-azetidinyl) -2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one::5-[2-butoxy-5-(1-hydroxyethyl)pyridin-3-yl]-3-ethyl-2-(1-ethylazetidin-3-yl)-2H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl alcohol analogue 55	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Canis lupus dingo		>3000					7.4	30.00 C	Curated from the literature by BindingDB	10.1021/jm060113e	10.7270/Q2C24TP4	16759100	aid1797217		Allerton, CM; Barber, CG; Beaumont, KC; Brown, DG; Cole, SM; Ellis, D; Lane, CA; Maw, GN; Mount, NM; Rawson, DJ; Robinson, CM; Street, SD; Summerhill, NW	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1540&target=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14395&enzyme=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search			6914589	46514735						ZINC24716039	1	MNLEPPKAEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII	1FQJ	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	CNRG_CANLF	P54827							
26302	CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(=O)CN1CCOCC1	InChI=1S/C23H29N5O4/c1-4-6-17-20-21(27(3)26-17)23(30)25-22(24-20)16-13-15(7-8-19(16)32-5-2)18(29)14-28-9-11-31-12-10-28/h7-8,13H,4-6,9-12,14H2,1-3H3,(H,24,25,30)	AANJEOKXWMXQIE-UHFFFAOYSA-N	14396	5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 56	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Canis lupus dingo		 1.4					7.4	30.00 C	Curated from the literature by BindingDB	10.1021/jm060113e	10.7270/Q2C24TP4	16759100	aid1797217		Allerton, CM; Barber, CG; Beaumont, KC; Brown, DG; Cole, SM; Ellis, D; Lane, CA; Maw, GN; Mount, NM; Rawson, DJ; Robinson, CM; Street, SD; Summerhill, NW	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14396	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1540&target=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14396&enzyme=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search			9824474	46514736						ZINC33970995	1	MNLEPPKAEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII	1FQJ	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	CNRG_CANLF	P54827							
26303	CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(C)=O	InChI=1S/C19H22N4O3/c1-5-7-14-16-17(23(4)22-14)19(25)21-18(20-16)13-10-12(11(3)24)8-9-15(13)26-6-2/h8-10H,5-7H2,1-4H3,(H,20,21,25)	YJBDHZKAVGNHET-UHFFFAOYSA-N	14397	5-(5-acetyl-2-ethoxyphenyl)-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 57	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	Canis lupus dingo		 0.9					7.4	30.00 C	Curated from the literature by BindingDB	10.1021/jm060113e	10.7270/Q2C24TP4	16759100	aid1797217		Allerton, CM; Barber, CG; Beaumont, KC; Brown, DG; Cole, SM; Ellis, D; Lane, CA; Maw, GN; Mount, NM; Rawson, DJ; Robinson, CM; Street, SD; Summerhill, NW	Pfizer Inc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14397	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1540&target=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14397&enzyme=Retinal+rod+rhodopsin-sensitive+cGMP+3%27%2C5%27-cyclic+phosphodiesterase+subunit+gamma&column=ki&startPg=0&Increment=50&submit=Search			21250674	46514737						ZINC14955547	1	MNLEPPKAEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII	1FQJ	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	CNRG_CANLF	P54827