BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 24730 CC(C)(Oc1ccccc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(O)=O InChI=1S/C21H27NO4/c1-20(2,26-16-6-4-3-5-7-16)18(23)22-17-14-8-13-9-15(17)12-21(10-13,11-14)19(24)25/h3-7,13-15,17H,8-12H2,1-2H3,(H,22,23)(H,24,25)/t13-,14+,15?,17+,21+/m0/s1 GIFJUNAMCWBYRP-ZXNQMZRGSA-N 13755 (1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)adamantane-1-carboxylic acid::adamantane ether 5 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 1500 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13755&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646479 46514142 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24731 CC(C)(Oc1ccccc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(N)=O InChI=1S/C21H28N2O3/c1-20(2,26-16-6-4-3-5-7-16)19(25)23-17-14-8-13-9-15(17)12-21(10-13,11-14)18(22)24/h3-7,13-15,17H,8-12H2,1-2H3,(H2,22,24)(H,23,25)/t13-,14+,15?,17+,21+/m0/s1 WLCAEXHUFPSPGJ-ZXNQMZRGSA-N 13756 (1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)adamantane-1-carboxamide::adamantane ether 6 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 40000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13756&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646480 46514143 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24732 CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(O)=O InChI=1S/C21H26ClNO4/c1-20(2,27-16-6-4-3-5-15(16)22)18(24)23-17-13-7-12-8-14(17)11-21(9-12,10-13)19(25)26/h3-6,12-14,17H,7-11H2,1-2H3,(H,23,24)(H,25,26)/t12-,13+,14?,17+,21+/m0/s1 UIIZCFCYQSHWAX-PRXKHIFWSA-N 13757 (1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropanamido]adamantane-1-carboxylic acid::adamantane ether 7 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 140 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13757&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646481 46514144 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24733 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(O)=O InChI=1S/C21H26ClNO4/c1-20(2,27-16-5-3-4-15(22)8-16)18(24)23-17-13-6-12-7-14(17)11-21(9-12,10-13)19(25)26/h3-5,8,12-14,17H,6-7,9-11H2,1-2H3,(H,23,24)(H,25,26)/t12-,13+,14?,17+,21+/m0/s1 CBUFQCLXNNQQNG-PRXKHIFWSA-N 13758 (1R,3R,4S,7S)-4-[2-(3-chlorophenoxy)-2-methylpropanamido]adamantane-1-carboxylic acid::adamantane ether 8 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 540 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13758&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646482 46514145 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24734 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(O)=O InChI=1S/C21H26ClNO4/c1-20(2,27-16-5-3-15(22)4-6-16)18(24)23-17-13-7-12-8-14(17)11-21(9-12,10-13)19(25)26/h3-6,12-14,17H,7-11H2,1-2H3,(H,23,24)(H,25,26)/t12-,13+,14?,17+,21+/m0/s1 QILGSQJABZWEBZ-PRXKHIFWSA-N 13759 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]adamantane-1-carboxylic acid::adamantane ether 9 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 1700 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13759&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646483 46514146 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24735 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(N)=O InChI=1S/C21H27ClN2O3/c1-20(2,27-16-5-3-15(22)4-6-16)19(26)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)25/h3-6,12-14,17H,7-11H2,1-2H3,(H2,23,25)(H,24,26)/t12-,13+,14?,17+,21+/m0/s1 DMVIIJMQXBNBLF-PRXKHIFWSA-N 13760 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]adamantane-1-carboxamide::adamantane ether 10 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 40000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13760&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646484 46514147 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24736 COc1ccc(OC(C)(C)C(=O)N[C@H]2C3C[C@@H]4C[C@@H]2C[C@](C4)(C3)C(N)=O)cc1 InChI=1S/C22H30N2O4/c1-21(2,28-17-6-4-16(27-3)5-7-17)20(26)24-18-14-8-13-9-15(18)12-22(10-13,11-14)19(23)25/h4-7,13-15,18H,8-12H2,1-3H3,(H2,23,25)(H,24,26)/t13-,14+,15?,18+,22+/m0/s1 MNVKIDPRYUGTTG-HAKNXOCISA-N 13761 (1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylpropanamido]adamantane-1-carboxamide::adamantane ether 15 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 55000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13761&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646485 46514148 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24737 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccc(cc1)C(O)=O InChI=1S/C29H33ClN2O5/c1-28(2,37-23-9-7-22(30)8-10-23)26(35)32-24-20-11-18-12-21(24)15-29(13-18,14-20)27(36)31-16-17-3-5-19(6-4-17)25(33)34/h3-10,18,20-21,24H,11-16H2,1-2H3,(H,31,36)(H,32,35)(H,33,34)/t18-,20+,21?,24+,29+/m0/s1 DCBFGNRLHATVPF-QTRCPRJISA-N 13762 4-({[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]adamantan-1-yl]formamido}methyl)benzoic acid::adamantane ether 16 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 5800 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13762&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646486 46514149 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24738 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccc(cc1)C(=O)NS(C)(=O)=O InChI=1S/C30H36ClN3O6S/c1-29(2,40-24-10-8-23(31)9-11-24)27(36)33-25-21-12-19-13-22(25)16-30(14-19,15-21)28(37)32-17-18-4-6-20(7-5-18)26(35)34-41(3,38)39/h4-11,19,21-22,25H,12-17H2,1-3H3,(H,32,37)(H,33,36)(H,34,35)/t19-,21+,22?,25+,30+/m0/s1 FWQHBEAXEAYWHI-GKKRZKHLSA-N 13763 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-{[4-(methanesulfonylcarbamoyl)phenyl]methyl}adamantane-1-carboxamide::adamantane ether 17 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 10000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13763&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646487 46514150 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24739 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccc(cc1)-c1nnn[nH]1 InChI=1S/C29H33ClN6O3/c1-28(2,39-23-9-7-22(30)8-10-23)26(37)32-24-20-11-18-12-21(24)15-29(13-18,14-20)27(38)31-16-17-3-5-19(6-4-17)25-33-35-36-34-25/h3-10,18,20-21,24H,11-16H2,1-2H3,(H,31,38)(H,32,37)(H,33,34,35,36)/t18-,20+,21?,24+,29+/m0/s1 KGIDONLAXKMIKG-QTRCPRJISA-N 13764 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-{[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl]methyl}adamantane-1-carboxamide::adamantane ether 18 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 6200 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13764&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646488 46514151 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24740 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccc(cc1)S(N)(=O)=O InChI=1S/C28H34ClN3O5S/c1-27(2,37-22-7-5-21(29)6-8-22)25(33)32-24-19-11-18-12-20(24)15-28(13-18,14-19)26(34)31-16-17-3-9-23(10-4-17)38(30,35)36/h3-10,18-20,24H,11-16H2,1-2H3,(H,31,34)(H,32,33)(H2,30,35,36)/t18-,19+,20?,24+,28+/m0/s1 AGDRECLEKQYTNN-JCOWOXNLSA-N 13765 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-[(4-sulfamoylphenyl)methyl]adamantane-1-carboxamide::adamantane ether 19 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 16000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13765&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646489 46514152 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24741 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1cncs1 InChI=1S/C25H30ClN3O3S/c1-24(2,32-19-5-3-18(26)4-6-19)22(30)29-21-16-7-15-8-17(21)11-25(9-15,10-16)23(31)28-13-20-12-27-14-33-20/h3-6,12,14-17,21H,7-11,13H2,1-2H3,(H,28,31)(H,29,30)/t15-,16+,17?,21+,25+/m0/s1 IZDUDJSLGJQVDK-ILXNSQLQSA-N 13766 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-(1,3-thiazol-5-ylmethyl)adamantane-1-carboxamide::adamantane ether 20 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 21000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13766&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646490 46514153 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24742 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccncc1 InChI=1S/C27H32ClN3O3/c1-26(2,34-22-5-3-21(28)4-6-22)24(32)31-23-19-11-18-12-20(23)15-27(13-18,14-19)25(33)30-16-17-7-9-29-10-8-17/h3-10,18-20,23H,11-16H2,1-2H3,(H,30,33)(H,31,32)/t18-,19+,20?,23+,27+/m0/s1 ACTSGYPIYRZKBB-GKUJUCRCSA-N 13767 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide::adamantane ether 21 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 19000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13767&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646491 46514154 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24743 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCC(N)=O InChI=1S/C23H30ClN3O4/c1-22(2,31-17-5-3-16(24)4-6-17)20(29)27-19-14-7-13-8-15(19)11-23(9-13,10-14)21(30)26-12-18(25)28/h3-6,13-15,19H,7-12H2,1-2H3,(H2,25,28)(H,26,30)(H,27,29)/t13-,14+,15?,19+,23+/m0/s1 XFHOFUPMDXTOPP-KNZQEESGSA-N 13768 N-[(1R,2S,5R,7S)-5-[(carbamoylmethyl)carbamoyl]adamantan-2-yl]-2-(4-chlorophenoxy)-2-methylpropanamide::adamantane ether 22 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 90000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13768&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646492 46514155 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24744 CNC(=O)NC(=O)[C@@]12C[C@@H]3CC(C1)[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)[C@H](C3)C2 InChI=1S/C23H30ClN3O4/c1-22(2,31-17-6-4-16(24)5-7-17)19(28)26-18-14-8-13-9-15(18)12-23(10-13,11-14)20(29)27-21(30)25-3/h4-7,13-15,18H,8-12H2,1-3H3,(H,26,28)(H2,25,27,29,30)/t13-,14+,15?,18+,23+/m0/s1 RJTGWEXIFPHKQR-CEZVUSQFSA-N 13769 2-(4-chlorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-{[(methylcarbamoyl)amino]carbonyl}adamantan-2-yl]propanamide::adamantane ether 23 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 16000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13769&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646493 46514156 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24745 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](CO)(C3)C2 InChI=1S/C21H28ClNO3/c1-20(2,26-17-5-3-16(22)4-6-17)19(25)23-18-14-7-13-8-15(18)11-21(9-13,10-14)12-24/h3-6,13-15,18,24H,7-12H2,1-2H3,(H,23,25)/t13-,14+,15?,18+,21+/m0/s1 SPQSNGFEASBQGI-IVAVVDRHSA-N 13770 2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymethyl)adamantan-2-yl]-2-methylpropanamide::adamantane ether 24 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13770&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646494 46514157 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24746 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](COCC(O)=O)(C3)C2 InChI=1S/C23H30ClNO5/c1-22(2,30-18-5-3-17(24)4-6-18)21(28)25-20-15-7-14-8-16(20)11-23(9-14,10-15)13-29-12-19(26)27/h3-6,14-16,20H,7-13H2,1-2H3,(H,25,28)(H,26,27)/t14-,15+,16?,20+,23+/m0/s1 ONHLADOANHWPPY-AXWDGYAMSA-N 13771 2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]adamantan-1-yl]methoxy}acetic acid::adamantane ether 25 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 45000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13771&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646495 46514158 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24747 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)c1nnn[nH]1 InChI=1S/C21H25ClFN5O2/c1-20(2,30-16-4-3-14(23)7-15(16)22)19(29)24-17-12-5-11-6-13(17)10-21(8-11,9-12)18-25-27-28-26-18/h3-4,7,11-13,17H,5-6,8-10H2,1-2H3,(H,24,29)(H,25,26,27,28)/t11-,12+,13?,17+,21+/m0/s1 SDLVFSDWSGBQTI-FEOKCCHMSA-N 13772 2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-(1H-1,2,3,4-tetrazol-5-yl)adamantan-2-yl]propanamide::adamantane ether 26 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 1200 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13772&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646496 46514159 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 24748 CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NS(C)(=O)=O InChI=1S/C22H29ClN2O5S/c1-21(2,30-17-7-5-4-6-16(17)23)19(26)24-18-14-8-13-9-15(18)12-22(10-13,11-14)20(27)25-31(3,28)29/h4-7,13-15,18H,8-12H2,1-3H3,(H,24,26)(H,25,27)/t13-,14+,15?,18+,22+/m0/s1 DFKJAMPFYWCPQV-HAKNXOCISA-N 13773 (1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropanamido]-N-methanesulfonyladamantane-1-carboxamide::adamantane ether 27 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 1200 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13773&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646497 46514160 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50099844 C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCn12 InChI=1S/C17H25N3/c1-2-4-15-18-19-16(20(15)5-3-1)17-9-12-6-13(10-17)8-14(7-12)11-17/h12-14H,1-11H2 VFTQRHWULYJKCI-UHFFFAOYSA-N 50239401 3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine::CHEMBL256777::MERCK-544 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >10000 ChEMBL 10.1021/jm4014746 10.7270/Q280546B 24294985 Scott, JS; Goldberg, FW; Turnbull, AV AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3630776 104056507 CHEMBL256777 ZINC05494877 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50322118 CCCCCC12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C21H35N3/c1-2-3-7-10-20-11-14-21(15-12-20,16-13-20)19-23-22-18-9-6-4-5-8-17-24(18)19/h2-17H2,1H3 HISKJZZJMYSEGO-UHFFFAOYSA-N 50174285 3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL200513 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 2100 ChEMBL 10.1016/j.bmcl.2005.08.052 10.7270/Q2QC031M 16185866 Gu, X; Dragovic, J; Koo, GC; Koprak, SL; LeGrand, C; Mundt, SS; Shah, K; Springer, MS; Tan, EY; Thieringer, R; Hermanowski-Vosatka, A; Zokian, HJ; Balkovec, JM; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174285&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11771845 104060103 CHEMBL200513 ZINC06717978 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50322129 COC(=O)C12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C18H27N3O2/c1-23-16(22)18-10-7-17(8-11-18,9-12-18)15-20-19-14-6-4-2-3-5-13-21(14)15/h2-13H2,1H3 IZAFVIFMEVBOTI-UHFFFAOYSA-N 50174294 CHEMBL200876::methyl 4-(5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)bicyclo[2.2.2]octane-1-carboxylate 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2005.08.052 10.7270/Q2QC031M 16185866 Gu, X; Dragovic, J; Koo, GC; Koprak, SL; LeGrand, C; Mundt, SS; Shah, K; Springer, MS; Tan, EY; Thieringer, R; Hermanowski-Vosatka, A; Zokian, HJ; Balkovec, JM; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174294&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11278558 104060112 CHEMBL200876 ZINC28562849 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50322140 C(C1CC1)c1noc(n1)C12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C22H31N5O/c1-2-4-14-27-18(5-3-1)24-25-19(27)21-8-11-22(12-9-21,13-10-21)20-23-17(26-28-20)15-16-6-7-16/h16H,1-15H2 BXRXOYXFCQSGFT-UHFFFAOYSA-N 50174289 3-(4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL200365 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2005.08.052 10.7270/Q2QC031M 16185866 Gu, X; Dragovic, J; Koo, GC; Koprak, SL; LeGrand, C; Mundt, SS; Shah, K; Springer, MS; Tan, EY; Thieringer, R; Hermanowski-Vosatka, A; Zokian, HJ; Balkovec, JM; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174289&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11280485 104060107 CHEMBL200365 ZINC06717985 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50322141 Clc1ccc(cc1)-c1noc(n1)C12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C24H28ClN5O/c25-18-8-6-17(7-9-18)20-26-22(31-29-20)24-13-10-23(11-14-24,12-15-24)21-28-27-19-5-3-1-2-4-16-30(19)21/h6-9H,1-5,10-16H2 YWNBNSZDPNFYMX-UHFFFAOYSA-N 50174279 3-(4-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL372768 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 4000 ChEMBL 10.1016/j.bmcl.2005.08.052 10.7270/Q2QC031M 16185866 Gu, X; Dragovic, J; Koo, GC; Koprak, SL; LeGrand, C; Mundt, SS; Shah, K; Springer, MS; Tan, EY; Thieringer, R; Hermanowski-Vosatka, A; Zokian, HJ; Balkovec, JM; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174279&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11259177 104060097 CHEMBL372768 ZINC28529086 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50322146 Cc1noc(n1)C12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C19H27N5O/c1-14-20-17(25-23-14)19-10-7-18(8-11-19,9-12-19)16-22-21-15-6-4-2-3-5-13-24(15)16/h2-13H2,1H3 KICDTKNTZWAWJS-UHFFFAOYSA-N 50174280 3-(4-(3-methyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL200351 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2005.08.052 10.7270/Q2QC031M 16185866 Gu, X; Dragovic, J; Koo, GC; Koprak, SL; LeGrand, C; Mundt, SS; Shah, K; Springer, MS; Tan, EY; Thieringer, R; Hermanowski-Vosatka, A; Zokian, HJ; Balkovec, JM; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174280&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11739354 104060098 CHEMBL200351 ZINC28563041 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50327783 CO[C@@H]1CC(=O)[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C23H38O4/c1-20(2)15-7-10-22(4)16(21(15,3)9-8-17(20)25)11-13(24)19-14(27-6)12-18(26)23(19,22)5/h13-17,19,24-25H,7-12H2,1-6H3/t13-,14-,15+,16-,17+,19-,21+,22-,23-/m1/s1 ZENVSCKOBKOTSJ-RTFSNDOKSA-N 50080424 CHEMBL3422264 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 291600 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080424&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911911 313074181 CHEMBL3422264 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50327784 CO[C@@H]1CC(=O)[C@]2(C)[C@@H]1[C@@H](C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C)OC(C)=O InChI=1S/C25H40O5/c1-14(26)30-16-12-18-23(4)10-9-19(27)22(2,3)17(23)8-11-24(18,5)25(6)20(28)13-15(29-7)21(16)25/h15-19,21,27H,8-13H2,1-7H3/t15-,16-,17+,18-,19+,21+,23+,24-,25-/m1/s1 CTERVLHXMOVKJM-YLXWABNASA-N 50080413 CHEMBL3422265 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 155400 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080413&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911912 313074180 CHEMBL3422265 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50327785 CC(=O)O[C@@H]1C[C@@H]2[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]2(C)[C@@]2(C)[C@H]1[C@H](O)CC2=O InChI=1S/C24H38O5/c1-13(25)29-15-12-17-22(4)9-8-18(27)21(2,3)16(22)7-10-23(17,5)24(6)19(28)11-14(26)20(15)24/h14-18,20,26-27H,7-12H2,1-6H3/t14-,15-,16+,17-,18+,20+,22+,23-,24-/m1/s1 LUZLPULOHLRSON-AXEWUURISA-N 50080412 CHEMBL3422266 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >1000000 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080412&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911913 313074179 CHEMBL3422266 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50327786 C[C@]12[C@@H](C=CC1=O)[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C22H34O3/c1-19(2)15-8-11-21(4)16(20(15,3)10-9-17(19)24)12-14(23)13-6-7-18(25)22(13,21)5/h6-7,13-17,23-24H,8-12H2,1-5H3/t13-,14+,15-,16+,17-,20-,21+,22-/m0/s1 UUHVPIJALZYQLA-LNRMMRAHSA-N 50080411 CHEMBL3422415 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >1000000 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080411&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911914 313074178 CHEMBL3422415 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50327787 CC(=O)O[C@@H]1C[C@@H]2[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]2(C)[C@@]2(C)[C@H]1C=CC2=O InChI=1S/C24H36O4/c1-14(25)28-16-13-18-22(4)11-10-19(26)21(2,3)17(22)9-12-23(18,5)24(6)15(16)7-8-20(24)27/h7-8,15-19,26H,9-13H2,1-6H3/t15-,16+,17-,18+,19-,22-,23+,24-/m0/s1 PVKPXFJHPNYMGT-NRAQGITCSA-N 50080410 CHEMBL3422416 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 216600 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080410&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911915 313074177 CHEMBL3422416 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356201 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2COCC1C[C@H](C2)C(N)=O InChI=1S/C19H25ClN2O4/c1-19(2,26-15-5-3-14(20)4-6-15)18(24)22-16-12-7-11(17(21)23)8-13(16)10-25-9-12/h3-6,11-13,16H,7-10H2,1-2H3,(H2,21,23)(H,22,24)/t11-,12?,13?,16- RHXKGFMFYVEJCA-GKGIWJEVSA-N 50192675 (7r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido)-3-oxa-bicyclo[3.3.1]nonane-7-carboxamide::CHEMBL376272 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192675&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418383 104075534 CHEMBL376272 ZINC36286132 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356204 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C24H34F3N5O2/c1-23(2,22(34)30-20-15-4-3-5-16(20)13-17(12-15)21(28)33)32-10-8-31(9-11-32)19-7-6-18(14-29-19)24(25,26)27/h6-7,14-17,20H,3-5,8-13H2,1-2H3,(H2,28,33)(H,30,34)/t15?,16?,17-,20- SXGLAMMLCWTPKO-MXYWLUFOSA-N 50192672 (3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL219403 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 85000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192672&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418445 104075531 CHEMBL219403 ZINC36286151 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356207 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)NC1CC[C@H]2[C@@H](CC1)[C@@H]2C(N)=O InChI=1S/C23H32F3N5O2/c1-22(2,21(33)29-15-4-6-16-17(7-5-15)19(16)20(27)32)31-11-9-30(10-12-31)18-8-3-14(13-28-18)23(24,25)26/h3,8,13,15-17,19H,4-7,9-12H2,1-2H3,(H2,27,32)(H,29,33)/t15?,16-,17+,19+ OJTRJEAMMHBCDD-VVXSQCBMSA-N 50192677 (1R,7S,8r)-4-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[5.1.0]octane-8-carboxamide::CHEMBL375743 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192677&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418434 104075536 CHEMBL375743 ZINC36286147 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356211 CC(C)(Oc1ccc(Cl)cc1)C(=O)NC1CCCC(CCC1)C#N InChI=1S/C19H25ClN2O2/c1-19(2,24-17-11-9-15(20)10-12-17)18(23)22-16-7-3-5-14(13-21)6-4-8-16/h9-12,14,16H,3-8H2,1-2H3,(H,22,23) XXQVINRKAJUVSG-UHFFFAOYSA-N 50192671 2-(4-chlorophenoxy)-N-(5-cyanocyclooctyl)-2-methylpropanamide::CHEMBL387010 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192671&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418457 104075530 CHEMBL387010 ZINC36286164 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356219 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)NC12CCC(CC1)(CC2)C(N)=O InChI=1S/C23H32F3N5O2/c1-20(2,19(33)29-22-8-5-21(6-9-22,7-10-22)18(27)32)31-13-11-30(12-14-31)17-4-3-16(15-28-17)23(24,25)26/h3-4,15H,5-14H2,1-2H3,(H2,27,32)(H,29,33) ZJEWQOHEBJRFFN-UHFFFAOYSA-N 50192674 4-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[2.2.2]octane-1-carboxamide::CHEMBL218247 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192674&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418456 104075533 CHEMBL218247 ZINC36286166 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356223 CC(C)(Oc1ccc(cn1)C#N)C(=O)N[C@@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C20H26N4O3/c1-20(2,27-16-7-6-12(10-21)11-23-16)19(26)24-17-13-4-3-5-14(17)9-15(8-13)18(22)25/h6-7,11,13-15,17H,3-5,8-9H2,1-2H3,(H2,22,25)(H,24,26)/t13?,14?,15-,17+ HYHSWNNFVLLHEA-MMKREDLLSA-N 50192684 (3s,9s)-9-(2-(5-cyanopyridin-2-yloxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL219295 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192684&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418375 104075543 CHEMBL219295 ZINC36286169 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356229 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H]1C2CCCC1C[C@H](C2)C(O)=O InChI=1S/C20H26ClNO4/c1-20(2,26-16-8-6-15(21)7-9-16)19(25)22-17-12-4-3-5-13(17)11-14(10-12)18(23)24/h6-9,12-14,17H,3-5,10-11H2,1-2H3,(H,22,25)(H,23,24)/t12?,13?,14-,17+ MGYATIZKIVDSGV-QODXQOHISA-N 50192685 (3s,9s)-9-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxylic acid::CHEMBL386315 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 1820 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192685&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418376 104075544 CHEMBL386315 ZINC36286176 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356231 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C20H27ClN2O3/c1-20(2,26-16-8-6-15(21)7-9-16)19(25)23-17-12-4-3-5-13(17)11-14(10-12)18(22)24/h6-9,12-14,17H,3-5,10-11H2,1-2H3,(H2,22,24)(H,23,25)/t12?,13?,14-,17- VSBPAZLSKLWBGS-HFVRJFBJSA-N 50192679 (3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL219448 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192679&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418382 104075538 CHEMBL219448 ZINC29126263 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356237 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)NC1CCCC(CCC1)C#N InChI=1S/C23H32F3N5O/c1-22(2,21(32)29-19-7-3-5-17(15-27)6-4-8-19)31-13-11-30(12-14-31)20-10-9-18(16-28-20)23(24,25)26/h9-10,16-17,19H,3-8,11-14H2,1-2H3,(H,29,32) DJTWBQCPSRQQDF-UHFFFAOYSA-N 50192681 CHEMBL218246::N-(5-cyanocyclooctyl)-2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192681&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418433 104075540 CHEMBL218246 ZINC36286142 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356241 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CCC1C[C@H](C2)C(O)=O InChI=1S/C23H31F3N4O3/c1-22(2,21(33)28-19-14-3-4-15(19)12-16(11-14)20(31)32)30-9-7-29(8-10-30)18-6-5-17(13-27-18)23(24,25)26/h5-6,13-16,19H,3-4,7-12H2,1-2H3,(H,28,33)(H,31,32)/t14?,15?,16-,19- XJQAEHQNLAKSQM-MUZLMXHHSA-N 50192682 (3r,8r)-8-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.2.1]octane-3-carboxylic acid::CHEMBL216783 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >10000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192682&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418441 104075541 CHEMBL216783 ZINC36286384 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356249 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C24H34F3N5O2/c1-23(2,22(34)30-20-15-4-3-5-16(20)13-17(12-15)21(28)33)32-10-8-31(9-11-32)19-7-6-18(14-29-19)24(25,26)27/h6-7,14-17,20H,3-5,8-13H2,1-2H3,(H2,28,33)(H,30,34)/t15?,16?,17-,20- SXGLAMMLCWTPKO-MXYWLUFOSA-N 50192672 (3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL219403 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >30000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192672&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418445 104075531 CHEMBL219403 ZINC36286151 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356266 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C24H34F3N5O2/c1-23(2,22(34)30-20-15-4-3-5-16(20)13-17(12-15)21(28)33)32-10-8-31(9-11-32)19-7-6-18(14-29-19)24(25,26)27/h6-7,14-17,20H,3-5,8-13H2,1-2H3,(H2,28,33)(H,30,34)/t15?,16?,17-,20+ SXGLAMMLCWTPKO-SUFHFBDXSA-N 50192683 (3s,9s)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL384426 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >30000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192683&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418445 104075542 CHEMBL384426 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356273 CC(C)(Oc1ccc(Cl)cc1)C(=O)NC12CCC(CC1)(CC2)C(N)=O InChI=1S/C19H25ClN2O3/c1-17(2,25-14-5-3-13(20)4-6-14)16(24)22-19-10-7-18(8-11-19,9-12-19)15(21)23/h3-6H,7-12H2,1-2H3,(H2,21,23)(H,22,24) LJXXAAVCYKDWBK-UHFFFAOYSA-N 50192686 4-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo[2.2.2]octane-1-carboxamide::CHEMBL219606 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192686&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 16049788 104075545 CHEMBL219606 ZINC34947170 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356274 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1CC(O)(C2)O3 InChI=1S/C19H24ClNO4/c1-18(2,24-14-5-3-13(20)4-6-14)17(22)21-16-11-7-15-8-12(16)10-19(23,9-11)25-15/h3-6,11-12,15-16,23H,7-10H2,1-2H3,(H,21,22)/t11?,12?,15?,16-,19? CTKDNRAPWIIIPH-XUGVBQLSSA-N 50192673 2-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxa-tricyclo[3.3.1.13,7]dec-6-yl)-2-methyl-propionamide::2-(4-chlorophenoxy)-N-(1-hydroxy-2-oxatricyclo[3.3.1.1~3,7~]dec-6-yl)-2-methylpropanamide::CHEMBL373601 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192673&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418389 104075532 CHEMBL373601 ZINC36286137 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356276 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(O)=O InChI=1S/C24H33F3N4O3/c1-23(2,22(34)29-20-15-4-3-5-16(20)13-17(12-15)21(32)33)31-10-8-30(9-11-31)19-7-6-18(14-28-19)24(25,26)27/h6-7,14-17,20H,3-5,8-13H2,1-2H3,(H,29,34)(H,32,33)/t15?,16?,17-,20- JBFDKOOTXBMPAU-MXYWLUFOSA-N 50192676 (3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxylic acid::CHEMBL374409 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 15000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192676&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418450 104075535 CHEMBL374409 ZINC36286158 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360503 OC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C1CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C26H33F3N4O3/c27-26(28,29)19-3-4-20(30-14-19)32-5-7-33(8-6-32)22(16-1-2-16)23(34)31-21-17-9-15-10-18(21)13-25(11-15,12-17)24(35)36/h3-4,14-18,21-22H,1-2,5-13H2,(H,31,34)(H,35,36)/t15?,17?,18?,21-,22?,25- KRSITBCUJXKYET-NNJMJYJPSA-N 50195288 4-{2-cyclopropyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetylamino}-adamantane-1-carboxylic acid::CHEMBL219712 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 2700 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195288&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11533520 104077357 CHEMBL219712 ZINC36286321 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360506 O[C@@]12C[C@H]3CC(C1)[C@H](NC(=O)C1(CC1)N1CCCCC1)C(C3)C2 InChI=1S/C19H30N2O2/c22-17(19(4-5-19)21-6-2-1-3-7-21)20-16-14-8-13-9-15(16)12-18(23,10-13)11-14/h13-16,23H,1-12H2,(H,20,22)/t13-,14?,15?,16-,18- CEZQNMXBDYZVET-NIYRFRDPSA-N 50195289 1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hydroxy-adamantan-2-yl)-amide::CHEMBL220102 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 26000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195289&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11666874 104077358 CHEMBL220102 ZINC36286294 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356364 CC(C)(Oc1ccc(cn1)-n1cccn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C24H31N5O3/c1-23(2,32-20-5-4-18(14-26-20)29-7-3-6-27-29)22(31)28-21-16-8-15-9-17(21)12-24(10-15,11-16)13-19(25)30/h3-7,14-17,21H,8-13H2,1-2H3,(H2,25,30)(H,28,31)/t15-,16-,17?,21+,24+/m0/s1 NOWYWFGCVSZISC-KVKMBOCQSA-N 50192792 CHEMBL219348::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-2-(5-pyrazol-1-yl-pyridin-2-yloxy)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192792&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418400 104075593 CHEMBL219348 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356372 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(C#N)c(N)o1 InChI=1S/C24H27ClN4O3/c1-23(2,32-17-5-3-16(25)4-6-17)21(30)29-19-14-7-13-8-15(19)11-24(9-13,10-14)22-28-18(12-26)20(27)31-22/h3-6,13-15,19H,7-11,27H2,1-2H3,(H,29,30)/t13-,14-,15?,19+,24+/m0/s1 GTHCHCGWMUMNIC-QYZWLEAQSA-N 50192796 CHEMBL219575::N-[(1R,2S,5S,7S)-5-(5-amino-4-cyano-oxazol-2-yl)-adamantan-2-yl]-2-(4-chloro-phenoxy)-2-methyl-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 50000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192796&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418447 104075597 CHEMBL219575 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356380 CC(C)(Oc1ccc(Br)cn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C21H28BrN3O3/c1-20(2,28-17-4-3-15(22)11-24-17)19(27)25-18-13-5-12-6-14(18)9-21(7-12,8-13)10-16(23)26/h3-4,11-14,18H,5-10H2,1-2H3,(H2,23,26)(H,25,27)/t12-,13-,14?,18+,21+/m0/s1 ZIMMKUOOHAWXLF-AYOVKPNZSA-N 50192791 2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL437522 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192791&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418390 104075592 CHEMBL437522 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360511 CCC(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(O)=O InChI=1S/C25H33F3N4O3/c1-2-19(31-5-7-32(8-6-31)20-4-3-18(14-29-20)25(26,27)28)22(33)30-21-16-9-15-10-17(21)13-24(11-15,12-16)23(34)35/h3-4,14-17,19,21H,2,5-13H2,1H3,(H,30,33)(H,34,35)/t15?,16?,17?,19?,21-,24- VUJKPYBHOITRIE-HSUQSKAJSA-N 50195293 4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butyrylamino}-adamantane-1-carboxylic acid::CHEMBL220153 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 5400 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195293&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420285 104077362 CHEMBL220153 ZINC36286312 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360527 NC(=O)[C@@]12C[C@H]3CC(C1)[C@H](NC(=O)C1(CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C25H32F3N5O2/c26-25(27,28)18-1-2-19(30-14-18)32-5-7-33(8-6-32)24(3-4-24)22(35)31-20-16-9-15-10-17(20)13-23(11-15,12-16)21(29)34/h1-2,14-17,20H,3-13H2,(H2,29,34)(H,31,35)/t15-,16?,17?,20-,23- TZQSUCROPTURHG-LYGRSXDVSA-N 50195292 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopropanecarbonyl}-amino)-adamantane-1-carboxylic acid amide::CHEMBL223804 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195292&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11705872 104077361 CHEMBL223804 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360542 CCC(N1CCCC(F)(F)C1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O InChI=1S/C20H31F2N3O2/c1-2-15(25-5-3-4-20(21,22)11-25)17(26)24-16-13-6-12-7-14(16)10-19(8-12,9-13)18(23)27/h12-16H,2-11H2,1H3,(H2,23,27)(H,24,26)/t12?,13?,14?,15?,16-,19- JPMYVYXSNDIXGT-IWGYBJIZSA-N 50195298 4-[2-(3,3-difluoro-piperidin-1-yl)-butyrylamino]-adamantane-1-carboxylic acid amide::CHEMBL222319 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195298&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420253 104077367 CHEMBL222319 ZINC36286353 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360543 OC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C1(CCCC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C27H35F3N4O3/c28-27(29,30)20-3-4-21(31-16-20)33-7-9-34(10-8-33)26(5-1-2-6-26)23(35)32-22-18-11-17-12-19(22)15-25(13-17,14-18)24(36)37/h3-4,16-19,22H,1-2,5-15H2,(H,32,35)(H,36,37)/t17?,18?,19?,22-,25- SCKUCAYPELQYOB-TZKYZTEESA-N 50195295 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopentanecarbonyl}-amino)-adamantane-1-carboxylic acid::CHEMBL222365 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 1100 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195295&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420294 104077364 CHEMBL222365 ZINC36286330 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360552 CC(C)(N1CCCCC1)C(=O)N[C@H]1C2C[C@H]3CC1C[C@](O)(C3)C2 InChI=1S/C19H32N2O2/c1-18(2,21-6-4-3-5-7-21)17(22)20-16-14-8-13-9-15(16)12-19(23,10-13)11-14/h13-16,23H,3-12H2,1-2H3,(H,20,22)/t13-,14?,15?,16-,19- QHTIJRCYQOYDKG-QVZPTTMKSA-N 50195304 CHEMBL220282::N-(5-hydroxy-adamantan-2-yl)-2-piperidin-1-yl-isobutyramide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195304&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420259 104077373 CHEMBL220282 ZINC36286356 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360554 NC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C1CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C26H34F3N5O2/c27-26(28,29)19-3-4-20(31-14-19)33-5-7-34(8-6-33)22(16-1-2-16)23(35)32-21-17-9-15-10-18(21)13-25(11-15,12-17)24(30)36/h3-4,14-18,21-22H,1-2,5-13H2,(H2,30,36)(H,32,35)/t15?,17?,18?,21-,22?,25- XGRHLBPSNKYHEK-NNJMJYJPSA-N 50195301 4-{2-cyclopropyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetylamino}-adamantane-1-carboxylic acid amide::CHEMBL222618 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195301&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11649095 104077370 CHEMBL222618 ZINC35936880 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360559 NC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C1(CCC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C26H34F3N5O2/c27-26(28,29)19-2-3-20(31-15-19)33-6-8-34(9-7-33)25(4-1-5-25)23(36)32-21-17-10-16-11-18(21)14-24(12-16,13-17)22(30)35/h2-3,15-18,21H,1,4-14H2,(H2,30,35)(H,32,36)/t16?,17?,18?,21-,24- YBLQVVARSOXHTM-DRQKDHDASA-N 50195299 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclobutanecarbonyl}-amino)-adamantane-1-carboxylic acid amide::CHEMBL222511 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 8900 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195299&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11555218 104077368 CHEMBL222511 ZINC34663384 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360560 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2C[C@H]3CC1C[C@](C3)(C2)C(O)=O InChI=1S/C25H33F3N4O3/c1-23(2,32-7-5-31(6-8-32)19-4-3-18(14-29-19)25(26,27)28)21(33)30-20-16-9-15-10-17(20)13-24(11-15,12-16)22(34)35/h3-4,14-17,20H,5-13H2,1-2H3,(H,30,33)(H,34,35)/t15-,16?,17?,20-,24- RVIKUVQZTJUNNT-HGYLWUCXSA-N 50195290 4-{2-methyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionylamino}-adamantane-1-carboxylic acid::CHEMBL376695 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 780 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195290&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11504178 104077359 CHEMBL376695 ZINC28604535 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360564 CCC(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O InChI=1S/C25H34F3N5O2/c1-2-19(32-5-7-33(8-6-32)20-4-3-18(14-30-20)25(26,27)28)22(34)31-21-16-9-15-10-17(21)13-24(11-15,12-16)23(29)35/h3-4,14-17,19,21H,2,5-13H2,1H3,(H2,29,35)(H,31,34)/t15?,16?,17?,19?,21-,24- WXXRNZHKHFPXPP-HSUQSKAJSA-N 50195302 4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butyrylamino}-adamantane-1-carboxylic acid amide::CHEMBL374110 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195302&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11540493 104077371 CHEMBL374110 ZINC34632092 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356386 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](Cc1nnn[nH]1)(C3)C2 InChI=1S/C22H28ClN5O2/c1-21(2,30-17-5-3-16(23)4-6-17)20(29)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18-25-27-28-26-18/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,29)(H,25,26,27,28)/t13-,14-,15?,19+,22+/m0/s1 YBVGWBXXKAHRFL-LDTIKURCSA-N 50192789 2-(4-chloro-phenoxy)-2-methyl-N-[(1S,2S,5R,7S)-5-(1H-tetrazol-5-ylmethyl)-adamantan-2-yl]-propionamide::CHEMBL424931 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 7000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192789&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418384 104075590 CHEMBL424931 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356398 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)C(=N)NO InChI=1S/C21H28ClN3O3/c1-20(2,28-16-5-3-15(22)4-6-16)19(26)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)25-27/h3-6,12-14,17,27H,7-11H2,1-2H3,(H2,23,25)(H,24,26)/t12-,13-,14?,17+,21+/m0/s1 QGTLXYMZZZDJFY-SOHFMQRKSA-N 50192790 2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(N-hydroxycarbamimidoyl)-adamantan-2-yl]-2-methyl-propionamide::CHEMBL375744 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192790&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418459 104075591 CHEMBL375744 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356403 CNc1ccc(cn1)C(C)(C)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C22H32N4O2/c1-21(2,16-4-5-18(24-3)25-12-16)20(28)26-19-14-6-13-7-15(19)10-22(8-13,9-14)11-17(23)27/h4-5,12-15,19H,6-11H2,1-3H3,(H2,23,27)(H,24,25)(H,26,28)/t13-,14-,15?,19+,22+/m0/s1 WRLITWGJOVVDNY-LDTIKURCSA-N 50192795 CHEMBL219081::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-(6-methylamino-pyridin-3-yl)-isobutyramide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192795&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418409 104075596 CHEMBL219081 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356404 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(O)=O)(C3)C2 InChI=1S/C22H28ClNO4/c1-21(2,28-17-5-3-16(23)4-6-17)20(27)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18(25)26/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,27)(H,25,26)/t13-,14-,15?,19+,22+/m0/s1 RKNILYVZCIUTKZ-LDTIKURCSA-N 50192801 CHEMBL220414::{(1R,4S,5R,7S)-4-[2-(4-chloro-phenoxy)-2-methyl-propionylamino]-adamantan-1-yl}-acetic acid 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 20700 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192801&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418378 104075602 CHEMBL220414 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356405 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ncc[nH]1 InChI=1S/C23H28ClN3O2/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)27-19-15-9-14-10-16(19)13-23(11-14,12-15)20-25-7-8-26-20/h3-8,14-16,19H,9-13H2,1-2H3,(H,25,26)(H,27,28)/t14-,15-,16?,19+,23+/m0/s1 XGDUOZKIZRASEM-XPFQKKRMSA-N 50192797 2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidazol-2-yl)-adamantan-2-yl]-2-methyl-propionamide::CHEMBL219137 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 10000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192797&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418452 104075598 CHEMBL219137 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356416 CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(nc1)N1CCOCC1 InChI=1S/C25H36N4O3/c1-24(2,19-3-4-21(27-15-19)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1 BMMNJMWULKMUEW-GZHLDQJQSA-N 50192799 CHEMBL375979::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-(6-morpholin-4-yl-pyridin-3-yl)-isobutyramide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192799&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418408 104075600 CHEMBL375979 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356418 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(=O)o[nH]1 InChI=1S/C22H26ClN3O4/c1-21(2,29-16-5-3-15(23)4-6-16)19(27)24-17-13-7-12-8-14(17)11-22(9-12,10-13)18-25-20(28)30-26-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,24,27)(H,25,26,28)/t12-,13-,14?,17+,22+/m0/s1 BQNOGCJLFJZJQU-FWQQIOJYSA-N 50192788 2-(4-chloro-phenoxy)-2-methyl-N-[(1R,2S,5S,7S)-5-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-adamantan-2-yl]-propionamide::CHEMBL436335 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192788&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418377 104075589 CHEMBL436335 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356420 CC(C)(Oc1ccc(cn1)C#N)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C22H28N4O3/c1-21(2,29-18-4-3-13(11-23)12-25-18)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-17(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1 YMCQQNULXBTOAK-ADYSRPFESA-N 50192785 CHEMBL385176::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-(5-cyano-pyridin-2-yloxy)-2-methyl-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192785&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418391 104075586 CHEMBL385176 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356424 CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(cn1)C#N InChI=1S/C22H28N4O2/c1-21(2,17-4-3-13(11-23)12-25-17)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-18(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1 ZFKLYMBYKJMHMS-ADYSRPFESA-N 50192798 CHEMBL219349::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-(5-cyano-pyridin-2-yl)-isobutyramide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 15000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192798&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418401 104075599 CHEMBL219349 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356429 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CCC(O)=O)(C3)C2 InChI=1S/C23H30ClNO4/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)25-20-15-9-14-10-16(20)13-23(11-14,12-15)8-7-19(26)27/h3-6,14-16,20H,7-13H2,1-2H3,(H,25,28)(H,26,27)/t14-,15-,16?,20+,23-/m0/s1 HHSFEYNQHTXPDX-AHTWWQKHSA-N 50192793 3-{(1R,4S,5R,7S)-4-[2-(4-chloro-phenoxy)-2-methyl-propionylamino]-adamantan-1-yl}-propionic acid::CHEMBL219028 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 28000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192793&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418385 104075594 CHEMBL219028 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356430 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ccno1 InChI=1S/C23H27ClN2O3/c1-22(2,28-18-5-3-17(24)4-6-18)21(27)26-20-15-9-14-10-16(20)13-23(11-14,12-15)19-7-8-25-29-19/h3-8,14-16,20H,9-13H2,1-2H3,(H,26,27)/t14-,15-,16?,20+,23+/m0/s1 PLQQJMFGNKDHGI-IRTUOURPSA-N 50192800 2-(4-chloro-phenoxy)-N-((1R,2S,5S,7S)-5-isoxazol-5-yl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL219428 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 15000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192800&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418458 104075601 CHEMBL219428 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356431 CN1CCN(CC1)c1ccc(OC(C)(C)C(=O)N[C@H]2C3C[C@@H]4C[C@H]2C[C@](CC(N)=O)(C4)C3)nc1 InChI=1S/C26H39N5O3/c1-25(2,34-22-5-4-20(16-28-22)31-8-6-30(3)7-9-31)24(33)29-23-18-10-17-11-19(23)14-26(12-17,13-18)15-21(27)32/h4-5,16-19,23H,6-15H2,1-3H3,(H2,27,32)(H,29,33)/t17-,18-,19?,23+,26+/m0/s1 MVRFQLOMWXUUJU-OECJZQBZSA-N 50192794 CHEMBL216977::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-2-[5-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192794&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418396 104075595 CHEMBL216977 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356433 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nnc(N)[nH]1 InChI=1S/C22H28ClN5O2/c1-21(2,30-16-5-3-15(23)4-6-16)19(29)25-17-13-7-12-8-14(17)11-22(9-12,10-13)18-26-20(24)28-27-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,25,29)(H3,24,26,27,28)/t12-,13-,14?,17+,22+/m0/s1 ABFKDXBHEQHAFL-FWQQIOJYSA-N 50192787 CHEMBL219136::N-[(1R,2S,5S,7S)-5-(5-amino-4H-[1,2,4]triazol-3-yl)-adamantan-2-yl]-2-(4-chloro-phenoxy)-2-methyl-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192787&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418451 104075588 CHEMBL219136 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50356440 CC(C)(Oc1ccc(cn1)N1CCOCC1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C25H36N4O4/c1-24(2,33-21-4-3-19(15-27-21)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1 PZSFNOREFIEVJQ-GZHLDQJQSA-N 50192786 CHEMBL216976::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-2-(5-morphlin-4-yl-pyridin-2-yloxy)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192786&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418395 104075587 CHEMBL216976 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360573 NC(=O)[C@@]12C[C@H]3CC(C1)[C@@H](NC(=O)C1(CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C25H32F3N5O2/c26-25(27,28)18-1-2-19(30-14-18)32-5-7-33(8-6-32)24(3-4-24)22(35)31-20-16-9-15-10-17(20)13-23(11-15,12-16)21(29)34/h1-2,14-17,20H,3-13H2,(H2,29,34)(H,31,35)/t15-,16?,17?,20+,23- TZQSUCROPTURHG-XJWUCTIFSA-N 50195287 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopropanecarbonyl}-amino)-adamantane-1-carboxylic acid amide::CHEMBL376293 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 90000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195287&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11705872 104077356 CHEMBL376293 ZINC36286303 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360574 OC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C1(CCC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C26H33F3N4O3/c27-26(28,29)19-2-3-20(30-15-19)32-6-8-33(9-7-32)25(4-1-5-25)22(34)31-21-17-10-16-11-18(21)14-24(12-16,13-17)23(35)36/h2-3,15-18,21H,1,4-14H2,(H,31,34)(H,35,36)/t16?,17?,18?,21-,24- BCQSMWWPXGIWEA-DRQKDHDASA-N 50195300 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclobutanecarbonyl}-amino)-adamantane-1-carboxylic acid::CHEMBL223138 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 1700 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195300&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11699075 104077369 CHEMBL223138 ZINC36286324 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360575 CCC(N1CCCC(F)(F)C1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(O)=O InChI=1S/C20H30F2N2O3/c1-2-15(24-5-3-4-20(21,22)11-24)17(25)23-16-13-6-12-7-14(16)10-19(8-12,9-13)18(26)27/h12-16H,2-11H2,1H3,(H,23,25)(H,26,27)/t12?,13?,14?,15?,16-,19- BZGXRUGRHXHQKS-IWGYBJIZSA-N 50195303 4-[2-(3,3-difluoro-piperidin-1-yl)-butyrylamino]-adamantane-1-carboxylic acid::CHEMBL223083 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 7700 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195303&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420249 104077372 CHEMBL223083 ZINC36286346 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360580 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2C[C@H]3CC1C[C@](C3)(C2)C(N)=O InChI=1S/C25H34F3N5O2/c1-23(2,33-7-5-32(6-8-33)19-4-3-18(14-30-19)25(26,27)28)22(35)31-20-16-9-15-10-17(20)13-24(11-15,12-16)21(29)34/h3-4,14-17,20H,5-13H2,1-2H3,(H2,29,34)(H,31,35)/t15-,16?,17?,20-,24- CLHMYBJIOZXCEX-HGYLWUCXSA-N 50195291 4-{2-methyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionylamino}-adamantane-1-carboxylic acid amide::CHEMBL222670 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 3600 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195291&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11670435 104077360 CHEMBL222670 7357 ZINC34643824 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360586 OC(=O)[C@@]12C[C@H]3CC(C1)[C@H](NC(=O)C1(CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C25H31F3N4O3/c26-25(27,28)18-1-2-19(29-14-18)31-5-7-32(8-6-31)24(3-4-24)21(33)30-20-16-9-15-10-17(20)13-23(11-15,12-16)22(34)35/h1-2,14-17,20H,3-13H2,(H,30,33)(H,34,35)/t15-,16?,17?,20-,23- DVRJUYYCTLYDFA-LYGRSXDVSA-N 50195294 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopropanecarbonyl}-amino)-adamantane-1-carboxylic acid::CHEMBL220883 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 3200 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195294&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11627334 104077363 CHEMBL220883 ZINC28604536 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360589 O[C@@]12C[C@H]3CC(C1)[C@@H](NC(=O)C1(CC1)N1CCCCC1)C(C3)C2 InChI=1S/C19H30N2O2/c22-17(19(4-5-19)21-6-2-1-3-7-21)20-16-14-8-13-9-15(16)12-18(23,10-13)11-14/h13-16,23H,1-12H2,(H,20,22)/t13-,14?,15?,16+,18- CEZQNMXBDYZVET-VWOQGHHKSA-N 50195297 1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hydroxy-adamantan-2-yl)-amide::CHEMBL221159 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195297&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11666874 104077366 CHEMBL221159 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50360595 NC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C1(CCCC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C27H36F3N5O2/c28-27(29,30)20-3-4-21(32-16-20)34-7-9-35(10-8-34)26(5-1-2-6-26)24(37)33-22-18-11-17-12-19(22)15-25(13-17,14-18)23(31)36/h3-4,16-19,22H,1-2,5-15H2,(H2,31,36)(H,33,37)/t17?,18?,19?,22-,25- DGTYTWGBTCSTOI-TZKYZTEESA-N 50195286 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopentanecarbonyl}-amino)-adamantane-1-carboxylic acid amide::CHEMBL373792 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 14000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195286&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420244 104077355 CHEMBL373792 ZINC36286336 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357723 CC1(C)C(COc2ccc(cn2)C#N)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)C1=O InChI=1S/C24H30N4O3/c1-23(2)18(13-31-19-4-3-14(10-25)11-27-19)12-28(22(23)30)20-16-5-15-6-17(20)9-24(7-15,8-16)21(26)29/h3-4,11,15-18,20H,5-9,12-13H2,1-2H3,(H2,26,29)/t15?,16?,17?,18?,20-,24- OHFPORFQCIWVDI-NFAVILPFSA-N 50193786 4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-adamantane-1-carboxylic acid amide::CHEMBL219049 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 10000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193786&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24890239 104076182 CHEMBL219049 ZINC35049141 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357725 CC1(C)C(COc2ccc(cc2)-n2ccnc2)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)C1=O InChI=1S/C27H34N4O3/c1-26(2)20(15-34-22-5-3-21(4-6-22)30-8-7-29-16-30)14-31(25(26)33)23-18-9-17-10-19(23)13-27(11-17,12-18)24(28)32/h3-8,16-20,23H,9-15H2,1-2H3,(H2,28,32)/t17?,18?,19?,20?,23-,27- AVSHDHHSWZFVQY-JTBBFVBSSA-N 50193784 4-[4-(4-imidazol-1-yl-phenoxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-adamantane-1-carboxylic acid amide::CHEMBL218120 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 14000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193784&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24890070 104076180 CHEMBL218120 ZINC28604038 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357732 CC1(C)C(COc2ccc(cn2)C#N)CN([C@H]2C3CCCC2C[C@H](C3)C(N)=O)C1=O InChI=1S/C23H30N4O3/c1-23(2)18(13-30-19-7-6-14(10-24)11-26-19)12-27(22(23)29)20-15-4-3-5-16(20)9-17(8-15)21(25)28/h6-7,11,15-18,20H,3-5,8-9,12-13H2,1-2H3,(H2,25,28)/t15?,16?,17-,18?,20- FPMIUFVSNVJQNM-ZIOKKRPGSA-N 50193785 (3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL221284 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >50000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193785&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889906 104076181 CHEMBL221284 ZINC35049139 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357733 CC1(C)C(COc2ccc(cn2)C(F)(F)F)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=N)C1=O InChI=1S/C24H31F3N4O2/c1-22(2)17(12-33-18-4-3-16(10-30-18)24(25,26)27)11-31(21(22)32)19-14-5-13-6-15(19)9-23(7-13,8-14)20(28)29/h3-4,10,13-15,17,19H,5-9,11-12H2,1-2H3,(H3,28,29)/t13?,14?,15?,17?,19-,23- DIFGDVMRNDYUGR-WFEZEDJFSA-N 50193791 4-[3,3-dimethyl-2-oxo-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-1-yl]-adamantane-1-carboxamidine::CHEMBL376226 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193791&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24890073 104076187 CHEMBL376226 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357740 CCOC(=O)[C@@H]1[C@H]2CCC(CC[C@@H]12)N1CC(COc2ccc(cn2)C#N)C(C)(C)C1=O InChI=1S/C24H31N3O4/c1-4-30-22(28)21-18-8-6-17(7-9-19(18)21)27-13-16(24(2,3)23(27)29)14-31-20-10-5-15(11-25)12-26-20/h5,10,12,16-19,21H,4,6-9,13-14H2,1-3H3/t16?,17?,18-,19+,21+ WQKGQPVBVCVYEK-IZHWVNFWSA-N 50193783 (1R,7S,8r)-ethyl 4-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[5.1.0]octane-8-carboxylate::CHEMBL218943 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193783&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889907 104076179 CHEMBL218943 ZINC36286222 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357741 CC1(C)C(COc2ccc(cn2)C#N)CN(C2CCCCCC2)C1=O InChI=1S/C20H27N3O2/c1-20(2)16(14-25-18-10-9-15(11-21)12-22-18)13-23(19(20)24)17-7-5-3-4-6-8-17/h9-10,12,16-17H,3-8,13-14H2,1-2H3 IIOIWTHGGFXVPM-UHFFFAOYSA-N 50193790 6-((1-cycloheptyl-4,4-dimethyl-5-oxopyrrolidin-3-yl)methoxy)nicotinonitrile::CHEMBL384650 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 100000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193790&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889741 104076186 CHEMBL384650 ZINC36286276 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357756 CC1(C)C(COc2ccc(cn2)C(F)(F)F)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(=N)NO)C1=O InChI=1S/C24H31F3N4O3/c1-22(2)17(12-34-18-4-3-16(10-29-18)24(25,26)27)11-31(21(22)32)19-14-5-13-6-15(19)9-23(7-13,8-14)20(28)30-33/h3-4,10,13-15,17,19,33H,5-9,11-12H2,1-2H3,(H2,28,30)/t13?,14?,15?,17?,19-,23- UZCSLSQPVOHMEK-WFEZEDJFSA-N 50193787 4-[3,3-dmethyl-2-oxo-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-1-yl]-N-hydroxy-adamantane-1-carboxamidine::CHEMBL267734 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 60000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193787&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44419309 104076183 CHEMBL267734 ZINC36286262 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357757 CC1(C)C(COc2ccc(cn2)C#N)CN([C@@H]2C3CCCC2C[C@H](C3)C(N)=O)C1=O InChI=1S/C23H30N4O3/c1-23(2)18(13-30-19-7-6-14(10-24)11-26-19)12-27(22(23)29)20-15-4-3-5-16(20)9-17(8-15)21(25)28/h6-7,11,15-18,20H,3-5,8-9,12-13H2,1-2H3,(H2,25,28)/t15?,16?,17-,18?,20+ FPMIUFVSNVJQNM-VRYLTXLISA-N 50193788 (3s,9s)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL218119 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193788&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889906 104076184 CHEMBL218119 ZINC35049139 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357770 CC1(C)C(COc2ccc(cn2)C(F)(F)F)CN([C@H]2C3CC4CC2C[C@](C4)(C3)c2nnn[nH]2)C1=O InChI=1S/C24H29F3N6O2/c1-22(2)17(12-35-18-4-3-16(10-28-18)24(25,26)27)11-33(21(22)34)19-14-5-13-6-15(19)9-23(7-13,8-14)20-29-31-32-30-20/h3-4,10,13-15,17,19H,5-9,11-12H2,1-2H3,(H,29,30,31,32)/t13?,14?,15?,17?,19-,23- JIPIIKUPMSVLEL-WFEZEDJFSA-N 50193796 3,3-dimethyl-1-[5-(1H-tetrazol-5-yl)-adamantan-2-yl]-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-2-one::CHEMBL218570 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 1600 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193796&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44419313 104076192 CHEMBL218570 ZINC36286269 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357772 CC1(C)C(COc2ccc(cn2)C#N)CN(C1=O)C12CCC(CC1)(CC2)C(N)=O InChI=1S/C22H28N4O3/c1-20(2)16(14-29-17-4-3-15(11-23)12-25-17)13-26(19(20)28)22-8-5-21(6-9-22,7-10-22)18(24)27/h3-4,12,16H,5-10,13-14H2,1-2H3,(H2,24,27) RIECCHAKVDPPHN-UHFFFAOYSA-N 50193795 34-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[2.2.2]octane-1-carboxamide::CHEMBL218569 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 100000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193795&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44419304 104076191 CHEMBL218569 ZINC36286246 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357776 CC1(C)C(COc2ccc(cn2)C#N)CN([C@H]2C3CCCC2C[C@H](C3)C(N)=O)C1=O InChI=1S/C23H30N4O3/c1-23(2)18(13-30-19-7-6-14(10-24)11-26-19)12-27(22(23)29)20-15-4-3-5-16(20)9-17(8-15)21(25)28/h6-7,11,15-18,20H,3-5,8-9,12-13H2,1-2H3,(H2,25,28)/t15?,16?,17-,18?,20- FPMIUFVSNVJQNM-ZIOKKRPGSA-N 50193785 (3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL221284 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 100000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193785&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889906 104076181 CHEMBL221284 ZINC35049139 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50357779 CC1(C)C(COc2ccc(cc2)-n2cncn2)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)C1=O InChI=1S/C26H33N5O3/c1-25(2)19(13-34-21-5-3-20(4-6-21)31-15-28-14-29-31)12-30(24(25)33)22-17-7-16-8-18(22)11-26(9-16,10-17)23(27)32/h3-6,14-19,22H,7-13H2,1-2H3,(H2,27,32)/t16?,17?,18?,19?,22-,26- NQCWDFHXAMUWTF-HCGXBOKKSA-N 50193789 4-[3,3-dimethyl-2-oxo-4-(4-[1,2,4]triazol-1-yl-phenoxymethyl)-pyrrolidin-1-yl]-adamantane-1-carboxylic acid amide::CHEMBL385777 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 8000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193789&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24890069 104076185 CHEMBL385777 ZINC36286255 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363863 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(=O)(=O)CC(N)=O InChI=1S/C22H28ClFN2O5S/c1-21(2,31-17-4-3-15(24)7-16(17)23)20(28)26-19-13-5-12-6-14(19)10-22(8-12,9-13)32(29,30)11-18(25)27/h3-4,7,12-14,19H,5-6,8-11H2,1-2H3,(H2,25,27)(H,26,28)/t12?,13?,14?,19-,22- PEERJNNYPXHLDJ-JPWRKOPWSA-N 50197412 CHEMBL241711::N-(5-carbamoylmethanesulfonyl-adamantan-2-yl)-2-(2-chloro-4-fluoro-phenoxy)-2-methyl-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197412&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438670 104078793 CHEMBL241711 ZINC28883197 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363864 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H27ClN2O4S/c1-19(2,27-16-5-3-15(21)4-6-16)18(24)23-17-13-7-12-8-14(17)11-20(9-12,10-13)28(22,25)26/h3-6,12-14,17H,7-11H2,1-2H3,(H,23,24)(H2,22,25,26)/t12?,13?,14?,17-,20- MEKFEFJATTVXSH-OQZFIPPTSA-N 50197402 2-(4-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL392932 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197402&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11604308 104078783 CHEMBL392932 ZINC28883544 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363867 CC(C)(Oc1ccccc1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H28N2O4S/c1-19(2,26-16-6-4-3-5-7-16)18(23)22-17-14-8-13-9-15(17)12-20(10-13,11-14)27(21,24)25/h3-7,13-15,17H,8-12H2,1-2H3,(H,22,23)(H2,21,24,25)/t13?,14?,15?,17-,20- RJFGXRMIXRFUOJ-UMTQXKRCSA-N 50197401 2-methyl-2-phenoxy-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL241719 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438679 104078782 CHEMBL241719 ZINC28883342 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363873 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H28ClNO4S/c1-20(2,27-17-6-4-5-16(22)9-17)19(24)23-18-14-7-13-8-15(18)12-21(10-13,11-14)28(3,25)26/h4-6,9,13-15,18H,7-8,10-12H2,1-3H3,(H,23,24)/t13?,14?,15?,18-,21- ALYTWLIPCNGVIJ-YLGPJNIESA-N 50197413 2-(3-chloro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241714 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197413&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438673 104078794 CHEMBL241714 ZINC28883252 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363875 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H27ClFNO4S/c1-20(2,28-17-5-4-15(23)8-16(17)22)19(25)24-18-13-6-12-7-14(18)11-21(9-12,10-13)29(3,26)27/h4-5,8,12-14,18H,6-7,9-11H2,1-3H3,(H,24,25)/t12?,13?,14?,18-,21- ULLPKOZNMAWTIP-RXAJHBGNSA-N 50197414 2-(2-chloro-4-fluoro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241707 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197414&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11655188 104078795 CHEMBL241707 ZINC16052179 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363878 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H26ClFN2O4S/c1-19(2,28-16-4-3-14(22)7-15(16)21)18(25)24-17-12-5-11-6-13(17)10-20(8-11,9-12)29(23,26)27/h3-4,7,11-13,17H,5-6,8-10H2,1-2H3,(H,24,25)(H2,23,26,27)/t11?,12?,13?,17-,20- SKQLNVOBAKAAKC-LURQHNEFSA-N 50197416 2-(2-chloro-4-fluoro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL391652 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197416&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11510573 104078797 CHEMBL391652 ZINC28883473 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363889 CC(C)(Oc1c(Cl)cc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H25Cl2FN2O4S/c1-19(2,29-17-14(21)5-13(23)6-15(17)22)18(26)25-16-11-3-10-4-12(16)9-20(7-10,8-11)30(24,27)28/h5-6,10-12,16H,3-4,7-9H2,1-2H3,(H,25,26)(H2,24,27,28)/t10?,11?,12?,16-,20- VUGLQUSKDGVICM-LBZAOVANSA-N 50197404 2-(2,6-dichloro-4-fluoro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL391653 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197404&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438682 104078785 CHEMBL391653 ZINC28883488 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363891 CC(C)(Oc1ccccc1OC(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C21H27F3N2O5S/c1-19(2,30-15-5-3-4-6-16(15)31-21(22,23)24)18(27)26-17-13-7-12-8-14(17)11-20(9-12,10-13)32(25,28)29/h3-6,12-14,17H,7-11H2,1-2H3,(H,26,27)(H2,25,28,29)/t12?,13?,14?,17-,20- KBPAWKAPWANKIO-OQZFIPPTSA-N 50197410 2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-2-(2-trifluoromethoxy-phenoxy)-propionamide::CHEMBL246858 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197410&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11576524 104078791 CHEMBL246858 ZINC28883458 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363898 CNS(=O)(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)C(C3)C2 InChI=1S/C21H29ClN2O4S/c1-20(2,28-17-6-4-16(22)5-7-17)19(25)24-18-14-8-13-9-15(18)12-21(10-13,11-14)29(26,27)23-3/h4-7,13-15,18,23H,8-12H2,1-3H3,(H,24,25)/t13?,14?,15?,18-,21- LAWOOLSGJUVOSC-YLGPJNIESA-N 50197419 2-(4-chloro-phenoxy)-2-methyl-N-(5-methylsulfamoyl-adamantan-2-yl)-propionamide::CHEMBL392913 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197419&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11626362 104078800 CHEMBL392913 ZINC28883385 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363911 CC(C)(Oc1ccccc1C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C22H28F3NO4S/c1-20(2,30-17-7-5-4-6-16(17)22(23,24)25)19(27)26-18-14-8-13-9-15(18)12-21(10-13,11-14)31(3,28)29/h4-7,13-15,18H,8-12H2,1-3H3,(H,26,27)/t13?,14?,15?,18-,21- HFZMOPIOWUPSSE-YLGPJNIESA-N 50197403 CHEMBL393167::N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-2-(2-trifluoromethyl-phenoxy)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197403&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438676 104078784 CHEMBL393167 ZINC28883280 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363914 COc1cc(F)ccc1OC(C)(C)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C22H30FNO5S/c1-21(2,29-17-6-5-16(23)9-18(17)28-3)20(25)24-19-14-7-13-8-15(19)12-22(10-13,11-14)30(4,26)27/h5-6,9,13-15,19H,7-8,10-12H2,1-4H3,(H,24,25)/t13?,14?,15?,19-,22- OXJFVFXQQOZVHD-TXBRZDKCSA-N 50197400 2-(4-fluoro-2-methoxy-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL240622 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197400&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438677 104078781 CHEMBL240622 ZINC28883302 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363915 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(=O)(=O)CCCN1CCOCC1 InChI=1S/C27H38ClFN2O5S/c1-26(2,36-23-5-4-21(29)14-22(23)28)25(32)30-24-19-12-18-13-20(24)17-27(15-18,16-19)37(33,34)11-3-6-31-7-9-35-10-8-31/h4-5,14,18-20,24H,3,6-13,15-17H2,1-2H3,(H,30,32)/t18?,19?,20?,24-,27- HVKZAAMCWANHEW-GIHQTTFSSA-N 50197407 2-(2-chloro-4-fluoro-phenoxy)-2-methyl-N-[5-(3-morpholin-4-yl-propane-1-sulfonyl)-adamantan-2-yl]-propionamide::CHEMBL240619 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 87000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197407&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438671 104078788 CHEMBL240619 ZINC28883230 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363922 CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H28ClNO4S/c1-20(2,27-17-7-5-4-6-16(17)22)19(24)23-18-14-8-13-9-15(18)12-21(10-13,11-14)28(3,25)26/h4-7,13-15,18H,8-12H2,1-3H3,(H,23,24)/t13?,14?,15?,18-,21- BOJWTWDRXNJANH-YLGPJNIESA-N 50197418 2-(2-chloro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL394217 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197418&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438672 104078799 CHEMBL394217 ZINC28883244 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363924 CCS(=O)(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C)(C)Oc1ccc(F)cc1Cl)C(C3)C2 InChI=1S/C22H29ClFNO4S/c1-4-30(27,28)22-10-13-7-14(11-22)19(15(8-13)12-22)25-20(26)21(2,3)29-18-6-5-16(24)9-17(18)23/h5-6,9,13-15,19H,4,7-8,10-12H2,1-3H3,(H,25,26)/t13?,14?,15?,19-,22- BPIBIOIIJZPFME-TXBRZDKCSA-N 50197409 2-(2-chloro-4-fluoro-phenoxy)-N-(5-ethanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241709 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197409&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438669 104078790 CHEMBL241709 ZINC28883181 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363933 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H28ClNO4S/c1-20(2,27-17-6-4-16(22)5-7-17)19(24)23-18-14-8-13-9-15(18)12-21(10-13,11-14)28(3,25)26/h4-7,13-15,18H,8-12H2,1-3H3,(H,23,24)/t13?,14?,15?,18-,21- RSHUECPBXOMFTQ-YLGPJNIESA-N 50197405 2-(4-chloro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241716 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197405&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438675 104078786 CHEMBL241716 ZINC28883271 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363938 CN(C)S(=O)(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)C(C3)C2 InChI=1S/C22H31ClN2O4S/c1-21(2,29-18-7-5-17(23)6-8-18)20(26)24-19-15-9-14-10-16(19)13-22(11-14,12-15)30(27,28)25(3)4/h5-8,14-16,19H,9-13H2,1-4H3,(H,24,26)/t14?,15?,16?,19-,22- VJHGNFUYSRHHAB-IDNYSXLCSA-N 50197406 2-(4-chloro-phenoxy)-N-(5-dimethylsulfamoyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL246442 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197406&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11712182 104078787 CHEMBL246442 ZINC28883404 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363939 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H27ClN2O4S/c1-19(2,27-16-5-3-4-15(21)8-16)18(24)23-17-13-6-12-7-14(17)11-20(9-12,10-13)28(22,25)26/h3-5,8,12-14,17H,6-7,9-11H2,1-2H3,(H,23,24)(H2,22,25,26)/t12?,13?,14?,17-,20- ZZXWSNKEDMSRRS-OQZFIPPTSA-N 50197408 2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL399191 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197408&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11502804 104078789 CHEMBL399191 ZINC28883372 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363940 CC(C)(C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O)c1ccccc1 InChI=1S/C20H28N2O3S/c1-19(2,16-6-4-3-5-7-16)18(23)22-17-14-8-13-9-15(17)12-20(10-13,11-14)26(21,24)25/h3-7,13-15,17H,8-12H2,1-2H3,(H,22,23)(H2,21,24,25)/t13?,14?,15?,17-,20- NNKZNDAYDMLMIA-UMTQXKRCSA-N 50197411 2-phenyl-N-(5-sulfamoyl-adamantan-2-yl)-isobutyramide::CHEMBL391447 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197411&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438681 104078792 CHEMBL391447 ZINC28883442 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363944 CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H27ClN2O4S/c1-19(2,27-16-6-4-3-5-15(16)21)18(24)23-17-13-7-12-8-14(17)11-20(9-12,10-13)28(22,25)26/h3-6,12-14,17H,7-11H2,1-2H3,(H,23,24)(H2,22,25,26)/t12?,13?,14?,17-,20- IKXWOMITWYKYSN-OQZFIPPTSA-N 50197399 2-(2-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL239373 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197399&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11618761 104078780 CHEMBL239373 ZINC28883357 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50363945 CC(C)(Oc1ccc(Cl)cc1F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H27ClFNO4S/c1-20(2,28-17-5-4-15(22)8-16(17)23)19(25)24-18-13-6-12-7-14(18)11-21(9-12,10-13)29(3,26)27/h4-5,8,12-14,18H,6-7,9-11H2,1-3H3,(H,24,25)/t12?,13?,14?,18-,21- AGGRAAZXMDOZHP-RXAJHBGNSA-N 50197417 2-(4-chloro-2-fluoro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241717 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197417&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438678 104078798 CHEMBL241717 ZINC28883322 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370404 CC(N1CCc2ccc3OCOc3c2CC1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C24H32N2O4/c1-14(23(27)25-21-17-8-15-9-18(21)12-24(28,10-15)11-17)26-6-4-16-2-3-20-22(30-13-29-20)19(16)5-7-26/h2-3,14-15,17-18,21,28H,4-13H2,1H3,(H,25,27)/t14?,15?,17?,18?,21-,24- BPEXEDGEGUHCBA-WDOFSTQFSA-N 50202087 CHEMBL374728::N-[(1R,3S)-5-hydroxy-2-adamantyl]-2-(6,7,9,10-tetrahydro-8H-[1,3]dioxolo[4,5-g][3]benzazepin-8-yl)propanamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202087&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418857 104081716 CHEMBL374728 ZINC35087400 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370407 O=C(CN1CCN(CC1)c1ncccc1C#N)NC1C2CC3CC(C2)CC1C3 InChI=1S/C22H29N5O/c23-13-17-2-1-3-24-22(17)27-6-4-26(5-7-27)14-20(28)25-21-18-9-15-8-16(11-18)12-19(21)10-15/h1-3,15-16,18-19,21H,4-12,14H2,(H,25,28) LTTIAASWMSZBDG-UHFFFAOYSA-N 50202091 CHEMBL384364::N-adamantan-2-yl-2-[4-(3-cyano-pyridin-2-yl)-piperazin-1-yl]-acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202091&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10452320 104081720 CHEMBL384364 ZINC36286212 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370417 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C24H33F3N4O2/c1-22(2,21(32)29-20-16-9-15-10-17(20)13-23(33,11-15)12-16)31-7-5-30(6-8-31)19-4-3-18(14-28-19)24(25,26)27/h3-4,14-17,20,33H,5-13H2,1-2H3,(H,29,32)/t15?,16?,17?,20-,23- QTLNSFMROWVHJU-KOVCZQLCSA-N 50202097 CHEMBL424937::N-[(E)-5-hydroxy-2-adamantyl]-2-methyl-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propanamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202097&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11634114 104081726 CHEMBL424937 ZINC35974253 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370419 FC(F)(F)c1ccc(nc1)N1CCN(CC(=O)N[C@H]2C3CC4CC2C[C@@](F)(C4)C3)CC1 InChI=1S/C22H28F4N4O/c23-21-9-14-7-15(10-21)20(16(8-14)11-21)28-19(31)13-29-3-5-30(6-4-29)18-2-1-17(12-27-18)22(24,25)26/h1-2,12,14-16,20H,3-11,13H2,(H,28,31)/t14?,15?,16?,20-,21+ RUBWTVFAHWBQIP-JXJPVIIGSA-N 50202099 CHEMBL218358::N-[(Z)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202099&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11655097 104081728 CHEMBL218358 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370428 C[C@@H](N1CC[C@@H](F)C1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C17H27FN2O2/c1-10(20-3-2-14(18)9-20)16(21)19-15-12-4-11-5-13(15)8-17(22,6-11)7-12/h10-15,22H,2-9H2,1H3,(H,19,21)/t10-,11?,12?,13?,14-,15-,17-/m1/s1 ZFNDDTOHDPHZON-CRGRXCIBSA-N 50202095 CHEMBL415429::E-(2R)-(3R-fluoro-pyrrolidin-1-yl)-N-(5-hydroxy-adamantan-2-yl)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202095&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25210659 104081724 CHEMBL415429 ZINC35087385 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370429 OC12CC3CC(CC(C3)C1NC(=O)CN1CCN(CC1)c1ccc(cn1)C(F)(F)F)C2 InChI=1S/C22H29F3N4O2/c23-22(24,25)17-1-2-18(26-12-17)29-5-3-28(4-6-29)13-19(30)27-20-16-8-14-7-15(9-16)11-21(20,31)10-14/h1-2,12,14-16,20,31H,3-11,13H2,(H,27,30) HDLZHQFBHVJHLK-UHFFFAOYSA-N 50202098 CHEMBL218143::N-(1-hydroxy-adamantan-2-yl)-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202098&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418817 104081727 CHEMBL218143 ZINC35087349 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370434 O[C@@]12CC3CC(C1)[C@H](NC(=O)CN1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C22H29F3N4O2/c23-22(24,25)17-1-2-18(26-12-17)29-5-3-28(4-6-29)13-19(30)27-20-15-7-14-8-16(20)11-21(31,9-14)10-15/h1-2,12,14-16,20,31H,3-11,13H2,(H,27,30)/t14?,15?,16?,20-,21- PSFYSFYPFBYYCS-VWPUDVFHSA-N 50202086 CHEMBL219142::N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202086&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11495851 104081715 CHEMBL219142 ZINC36286181 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370442 O[C@]12CC3CC(C1)[C@H](NC(=O)CN1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C22H29F3N4O2/c23-22(24,25)17-1-2-18(26-12-17)29-5-3-28(4-6-29)13-19(30)27-20-15-7-14-8-16(20)11-21(31,9-14)10-15/h1-2,12,14-16,20,31H,3-11,13H2,(H,27,30)/t14?,15?,16?,20-,21+ PSFYSFYPFBYYCS-JXJPVIIGSA-N 50202089 CHEMBL373889::N-[(Z)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202089&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11495851 104081718 CHEMBL373889 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370454 CC(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C23H31F3N4O2/c1-14(21(31)28-20-16-8-15-9-17(20)12-22(32,10-15)11-16)29-4-6-30(7-5-29)19-3-2-18(13-27-19)23(24,25)26/h2-3,13-17,20,32H,4-12H2,1H3,(H,28,31)/t14?,15?,16?,17?,20-,22- RSIROJJHJFVYIR-AZXBVUDKSA-N 50202102 CHEMBL375156::N-(5-Hydroxy-adamantan-2-yl)-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionamide::N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202102&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11676805 104081731 CHEMBL375156 ZINC35087408 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370462 O[C@@]12CC3CC(C1)[C@H](NC(=O)CN1CC[C@@H](C1)C(F)(F)F)C(C3)C2 InChI=1S/C17H25F3N2O2/c18-17(19,20)13-1-2-22(8-13)9-14(23)21-15-11-3-10-4-12(15)7-16(24,5-10)6-11/h10-13,15,24H,1-9H2,(H,21,23)/t10?,11?,12?,13-,15-,16-/m0/s1 YCPHGDKLMMKHEC-FRWGEJJCSA-N 50202094 CHEMBL375341::N-(5-hydroxy-adamantan-2-yl)-2-(3-trifluoromethyl-pyrrolidin-1-yl)-acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202094&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418821 104081723 CHEMBL375341 ZINC35087382 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370464 FC(F)(F)c1ccc(nc1)N1CCN(CC(=O)N[C@H]2C3CC4CC2C[C@](F)(C4)C3)CC1 InChI=1S/C22H28F4N4O/c23-21-9-14-7-15(10-21)20(16(8-14)11-21)28-19(31)13-29-3-5-30(6-4-29)18-2-1-17(12-27-18)22(24,25)26/h1-2,12,14-16,20H,3-11,13H2,(H,28,31)/t14?,15?,16?,20-,21- RUBWTVFAHWBQIP-VWPUDVFHSA-N 50202092 CHEMBL386029::N-[(E)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202092&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11655097 104081721 CHEMBL386029 ZINC34630950 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370503 C[C@H](N1CC[C@@H](F)C1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C17H27FN2O2/c1-10(20-3-2-14(18)9-20)16(21)19-15-12-4-11-5-13(15)8-17(22,6-11)7-12/h10-15,22H,2-9H2,1H3,(H,19,21)/t10-,11?,12?,13?,14+,15-,17-/m0/s1 ZFNDDTOHDPHZON-IXXSQMGDSA-N 50202106 CHEMBL218758::E-(2S)-(3R-fluoro-pyrrolidin-1-yl)-N-(5-hydroxy-adamantan-2-yl)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202106&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418852 104081735 CHEMBL218758 ZINC35087387 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50370505 CC(N1CC(C1)Oc1ccccc1F)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C22H29FN2O3/c1-13(25-11-17(12-25)28-19-5-3-2-4-18(19)23)21(26)24-20-15-6-14-7-16(20)10-22(27,8-14)9-15/h2-5,13-17,20,27H,6-12H2,1H3,(H,24,26)/t13?,14?,15?,16?,20-,22- XNSQYEZFDGACIR-CXAITDPASA-N 50202093 2-[3-(2-fluoro-phenoxy)-azetidin-1-yl]-N-(5-hydroxy-adamantan-2-yl)-propionamide::CHEMBL217917 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202093&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418856 104081722 CHEMBL217917 ZINC35087396 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413483 C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCn12 InChI=1S/C17H25N3/c1-2-4-15-18-19-16(20(15)5-3-1)17-9-12-6-13(10-17)8-14(7-12)11-17/h12-14H,1-11H2 VFTQRHWULYJKCI-UHFFFAOYSA-N 50239401 3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine::CHEMBL256777::MERCK-544 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >10000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3630776 104056507 CHEMBL256777 ZINC05494877 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413490 Clc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22ClN3/c19-15-9-7-14(8-10-15)18(11-5-12-18)17-21-20-16-6-3-1-2-4-13-22(16)17/h7-10H,1-6,11-13H2 FDLFGCPTRMXATH-UHFFFAOYSA-N 50239407 3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::3-[1-(4-Chloro-phenyl)-cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL257149 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239407&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10335880 104056508 CHEMBL257149 ZINC29044661 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413491 Cn1c(nnc1C12CC3CC(CC(C3)C1)C2)-c1ccccc1 InChI=1S/C19H23N3/c1-22-17(16-5-3-2-4-6-16)20-21-18(22)19-10-13-7-14(11-19)9-15(8-13)12-19/h2-6,13-15H,7-12H2,1H3 SPLKSRDVCTUAGF-UHFFFAOYSA-N 50239276 3-Adamantan-1-yl-4-methyl-5-phenyl-4H-[1,2,4]triazole::CHEMBL428429 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239276&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10193044 104056504 CHEMBL428429 ZINC13984397 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413621 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1cccc(c1)S(C)(=O)=O InChI=1S/C26H23Cl2N3O2S/c1-31-24(29-30-25(31)26(13-4-14-26)19-8-10-20(27)11-9-19)22-12-7-18(16-23(22)28)17-5-3-6-21(15-17)34(2,32)33/h3,5-12,15-16H,4,13-14H2,1-2H3 WMIKNIOIIKGHNU-UHFFFAOYSA-N 50260939 3-(3-Chloro-3'-methanesulfonyl-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL495889 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260939&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576875 104110276 CHEMBL495889 ZINC40954711 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413622 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1ccc(cc1)S(C)(=O)=O InChI=1S/C26H23Cl2N3O2S/c1-31-24(29-30-25(31)26(14-3-15-26)19-7-9-20(27)10-8-19)22-13-6-18(16-23(22)28)17-4-11-21(12-5-17)34(2,32)33/h4-13,16H,3,14-15H2,1-2H3 MRTRRNXAPPQNFC-UHFFFAOYSA-N 50260937 3-(3-Chloro-4'-methanesulfonyl-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL497122 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260937&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576873 104110274 CHEMBL497122 ZINC40974088 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413623 CCS(=O)(=O)c1cccc(c1)-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C27H25Cl2N3O2S/c1-3-35(33,34)22-7-4-6-18(16-22)19-8-13-23(24(29)17-19)25-30-31-26(32(25)2)27(14-5-15-27)20-9-11-21(28)12-10-20/h4,6-13,16-17H,3,5,14-15H2,1-2H3 MGHNCLCNTFQOTJ-UHFFFAOYSA-N 50261050 3-(3-Chloro-3'-ethanesulfonyl-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL521536 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261050&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576967 104110319 CHEMBL521536 ZINC42888480 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413624 CCS(=O)(=O)c1ccccc1-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C27H25Cl2N3O2S/c1-3-35(33,34)24-8-5-4-7-21(24)18-9-14-22(23(29)17-18)25-30-31-26(32(25)2)27(15-6-16-27)19-10-12-20(28)13-11-19/h4-5,7-14,17H,3,6,15-16H2,1-2H3 CTTCBVOJARTTMW-UHFFFAOYSA-N 50261010 3-(3-Chloro-2'-ethanesulfonyl-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL496307 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261010&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576945 104110303 CHEMBL496307 ZINC49881749 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413625 CCSc1ccccc1-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C27H25Cl2N3S/c1-3-33-24-8-5-4-7-21(24)18-9-14-22(23(29)17-18)25-30-31-26(32(25)2)27(15-6-16-27)19-10-12-20(28)13-11-19/h4-5,7-14,17H,3,6,15-16H2,1-2H3 FOYQEHAQUNUUQI-UHFFFAOYSA-N 50260911 3-(3-Chloro-2'-ethylsulfanyl-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL496495 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260911&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576849 104110260 CHEMBL496495 ZINC40976134 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413626 CCS(=O)(=O)c1ccc(cc1)-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C27H25Cl2N3O2S/c1-3-35(33,34)22-12-5-18(6-13-22)19-7-14-23(24(29)17-19)25-30-31-26(32(25)2)27(15-4-16-27)20-8-10-21(28)11-9-20/h5-14,17H,3-4,15-16H2,1-2H3 KWTGDOCRFJEKDS-UHFFFAOYSA-N 50261009 3-(3-Chloro-4'-ethanesulfonyl-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL497555 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261009&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576944 104110302 CHEMBL497555 ZINC49881784 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413627 Cc1nc2ccccc2n1-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C27H23Cl2N5/c1-17-30-23-6-3-4-7-24(23)34(17)20-12-13-21(22(29)16-20)25-31-32-26(33(25)2)27(14-5-15-27)18-8-10-19(28)11-9-18/h3-4,6-13,16H,5,14-15H2,1-2H3 QZIWMMWYFFSVIM-UHFFFAOYSA-N 50260909 1-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-2-methyl-1H-benzo[d]imidazole::CHEMBL494822 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260909&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576847 104110258 CHEMBL494822 ZINC40957065 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413629 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-n1ccnc1S(C)(=O)=O InChI=1S/C23H21Cl2N5O2S/c1-29-20(27-28-21(29)23(10-3-11-23)15-4-6-16(24)7-5-15)18-9-8-17(14-19(18)25)30-13-12-26-22(30)33(2,31)32/h4-9,12-14H,3,10-11H2,1-2H3 DZZBSMMXPNPOMM-UHFFFAOYSA-N 50261008 3-(2-chloro-4-(2-(methylsulfonyl)-1H-imidazol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL497554 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261008&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576943 104110301 CHEMBL497554 ZINC40431126 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413630 CSc1nccn1-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C23H21Cl2N5S/c1-29-20(18-9-8-17(14-19(18)25)30-13-12-26-22(30)31-2)27-28-21(29)23(10-3-11-23)15-4-6-16(24)7-5-15/h4-9,12-14H,3,10-11H2,1-2H3 ACOGDAFKFRVNDY-UHFFFAOYSA-N 50261007 3-(2-chloro-4-(2-(methylthio)-1H-imidazol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL524623 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261007&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576942 104110300 CHEMBL524623 ZINC40973588 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413631 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-n1ccnc1C(F)(F)F InChI=1S/C23H18Cl2F3N5/c1-32-19(30-31-20(32)22(9-2-10-22)14-3-5-15(24)6-4-14)17-8-7-16(13-18(17)25)33-12-11-29-21(33)23(26,27)28/h3-8,11-13H,2,9-10H2,1H3 IUBGICNCLXPBGO-UHFFFAOYSA-N 50260967 3-(2-chloro-4-(2-(trifluoromethyl)-1H-imidazol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL496714 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260967&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576902 104110289 CHEMBL496714 ZINC40976157 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413632 Cc1cn(c(n1)C1CC1)-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C26H25Cl2N5/c1-16-15-33(23(29-16)17-4-5-17)20-10-11-21(22(28)14-20)24-30-31-25(32(24)2)26(12-3-13-26)18-6-8-19(27)9-7-18/h6-11,14-15,17H,3-5,12-13H2,1-2H3 KFHSELJFIFOKEY-UHFFFAOYSA-N 50260966 3-(2-chloro-4-(2-cyclopropyl-4-methyl-1H-imidazol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL522572 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260966&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576901 104110288 CHEMBL522572 ZINC40428696 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413633 Cc1cn(c(C)n1)-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C24H23Cl2N5/c1-15-14-31(16(2)27-15)19-9-10-20(21(26)13-19)22-28-29-23(30(22)3)24(11-4-12-24)17-5-7-18(25)8-6-17/h5-10,13-14H,4,11-12H2,1-3H3 FFXVVCQJRRSTNG-UHFFFAOYSA-N 50260965 3-(2-chloro-4-(2,4-dimethyl-1H-imidazol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL498153 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260965&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576900 104110287 CHEMBL498153 ZINC40974682 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413634 Cc1nccn1-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C23H21Cl2N5/c1-15-26-12-13-30(15)18-8-9-19(20(25)14-18)21-27-28-22(29(21)2)23(10-3-11-23)16-4-6-17(24)7-5-16/h4-9,12-14H,3,10-11H2,1-2H3 CACAJKPBVJNEFC-UHFFFAOYSA-N 50260964 3-(2-chloro-4-(2-methyl-1H-imidazol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL525360 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260964&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576899 104110286 CHEMBL525360 ZINC40975745 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413635 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-n1ccnc1 InChI=1S/C22H19Cl2N5/c1-28-20(18-8-7-17(13-19(18)24)29-12-11-25-14-29)26-27-21(28)22(9-2-10-22)15-3-5-16(23)6-4-15/h3-8,11-14H,2,9-10H2,1H3 WIHGHYGCPZDKII-UHFFFAOYSA-N 50260938 3-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL523414 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260938&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576874 104110275 CHEMBL523414 ZINC40431134 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413636 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1ccccn1 InChI=1S/C24H20Cl2N4/c1-30-22(19-11-6-16(15-20(19)26)21-5-2-3-14-27-21)28-29-23(30)24(12-4-13-24)17-7-9-18(25)10-8-17/h2-3,5-11,14-15H,4,12-13H2,1H3 QUFVKZHNAOJTOG-UHFFFAOYSA-N 50260936 2-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyridine::CHEMBL497121 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260936&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576872 104110273 CHEMBL497121 ZINC40974086 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413637 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1ccncc1 InChI=1S/C24H20Cl2N4/c1-30-22(20-8-3-17(15-21(20)26)16-9-13-27-14-10-16)28-29-23(30)24(11-2-12-24)18-4-6-19(25)7-5-18/h3-10,13-15H,2,11-12H2,1H3 LXGZRMOAZHRDOH-UHFFFAOYSA-N 50260910 4-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyridine::CHEMBL522066 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260910&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576848 104110259 CHEMBL522066 ZINC40425278 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413638 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1cccnc1 InChI=1S/C24H20Cl2N4/c1-30-22(20-10-5-16(14-21(20)26)17-4-2-13-27-15-17)28-29-23(30)24(11-3-12-24)18-6-8-19(25)9-7-18/h2,4-10,13-15H,3,11-12H2,1H3 RAQAZKICFNGDBP-UHFFFAOYSA-N 50260908 3-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyridine::CHEMBL522701 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260908&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576846 104110257 CHEMBL522701 ZINC40430308 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413639 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1nccs1 InChI=1S/C22H19ClN4S/c1-27-19(15-3-5-16(6-4-15)20-24-13-14-28-20)25-26-21(27)22(11-2-12-22)17-7-9-18(23)10-8-17/h3-10,13-14H,2,11-12H2,1H3 UVSPAWUXRFWMOR-UHFFFAOYSA-N 50260882 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(thiazol-2-yl)phenyl)-4H-1,2,4-triazole::CHEMBL494639 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260882&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576805 104110243 CHEMBL494639 ZINC40954219 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413640 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-n1cccc1 InChI=1S/C23H21ClN4/c1-27-21(17-5-11-20(12-6-17)28-15-2-3-16-28)25-26-22(27)23(13-4-14-23)18-7-9-19(24)10-8-18/h2-3,5-12,15-16H,4,13-14H2,1H3 JPLLVYRQKLXUGS-UHFFFAOYSA-N 50260881 3-(4-(1H-pyrrol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL524040 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260881&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576804 104110242 CHEMBL524040 ZINC40953931 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413641 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-n1ccnc1 InChI=1S/C22H20ClN5/c1-27-20(16-3-9-19(10-4-16)28-14-13-24-15-28)25-26-21(27)22(11-2-12-22)17-5-7-18(23)8-6-17/h3-10,13-15H,2,11-12H2,1H3 HYLCZNXUPJNYNR-UHFFFAOYSA-N 50260879 3-(4-(1H-imidazol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL494637 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260879&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576803 104110240 CHEMBL494637 ZINC40429768 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413642 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(Oc2ccccc2)cc1 InChI=1S/C25H22ClN3O/c1-29-23(18-8-14-22(15-9-18)30-21-6-3-2-4-7-21)27-28-24(29)25(16-5-17-25)19-10-12-20(26)13-11-19/h2-4,6-15H,5,16-17H2,1H3 NOBNEGOCMCJSIK-UHFFFAOYSA-N 50260878 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-phenoxyphenyl)-4H-1,2,4-triazole::CHEMBL493801 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260878&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576802 104110239 CHEMBL493801 ZINC40952909 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413643 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(C)(C)C InChI=1S/C23H26ClN3/c1-22(2,3)17-8-6-16(7-9-17)20-25-26-21(27(20)4)23(14-5-15-23)18-10-12-19(24)13-11-18/h6-13H,5,14-15H2,1-4H3 NYCVQZBNPJYEDN-UHFFFAOYSA-N 50260825 3-(4-tert-butylphenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL497558 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260825&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576752 104110233 CHEMBL497558 ZINC40973590 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413644 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(Cc2ccccc2)cc1 InChI=1S/C26H24ClN3/c1-30-24(21-10-8-20(9-11-21)18-19-6-3-2-4-7-19)28-29-25(30)26(16-5-17-26)22-12-14-23(27)15-13-22/h2-4,6-15H,5,16-18H2,1H3 UJHFTEDLBITHDN-UHFFFAOYSA-N 50260824 3-(4-benzylphenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL495691 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260824&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576751 104110232 CHEMBL495691 ZINC40429253 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413645 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccc(F)cc1 InChI=1S/C25H21ClFN3/c1-30-23(19-5-3-17(4-6-19)18-7-13-22(27)14-8-18)28-29-24(30)25(15-2-16-25)20-9-11-21(26)12-10-20/h3-14H,2,15-16H2,1H3 VCTHRPMMDKRYPK-UHFFFAOYSA-N 50260823 3-[1-(4-Chloro-phenyl)-cyclobutyl]-5-(4'-fluoro-biphenyl-4-yl)-4-methyl-4H-[1,2,4]triazole::CHEMBL495690 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260823&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576750 104110231 CHEMBL495690 ZINC40956730 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413646 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(c1)-c1ccccc1 InChI=1S/C25H22ClN3/c1-29-23(20-10-5-9-19(17-20)18-7-3-2-4-8-18)27-28-24(29)25(15-6-16-25)21-11-13-22(26)14-12-21/h2-5,7-14,17H,6,15-16H2,1H3 FXLJWOWLNCXDCJ-UHFFFAOYSA-N 50260822 3-Biphenyl-3-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL525924 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260822&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576749 104110230 CHEMBL525924 ZINC40425303 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413647 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C25H22ClN3/c1-29-23(20-10-8-19(9-11-20)18-6-3-2-4-7-18)27-28-24(29)25(16-5-17-25)21-12-14-22(26)15-13-21/h2-4,6-15H,5,16-17H2,1H3 UXOKGMBZBAXMDM-UHFFFAOYSA-N 50260797 3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL525361 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260797&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10340916 104110217 CHEMBL525361 ZINC38558781 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413648 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(OC2CC2)cc1 InChI=1S/C22H22ClN3O/c1-26-20(15-3-9-18(10-4-15)27-19-11-12-19)24-25-21(26)22(13-2-14-22)16-5-7-17(23)8-6-16/h3-10,19H,2,11-14H2,1H3 UPOIRNUSRYYGME-UHFFFAOYSA-N 50260796 3-(1-(4-chlorophenyl)cyclobutyl)-5-(4-cyclopropoxyphenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL497960 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260796&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576707 104110216 CHEMBL497960 ZINC40425122 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413649 COc1ccc(cc1F)-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C20H19ClFN3O/c1-25-18(13-4-9-17(26-2)16(22)12-13)23-24-19(25)20(10-3-11-20)14-5-7-15(21)8-6-14/h4-9,12H,3,10-11H2,1-2H3 VMIACAXLJCXOQZ-UHFFFAOYSA-N 50260795 3-(1-(4-chlorophenyl)cyclobutyl)-5-(3-fluoro-4-methoxyphenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL496097 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260795&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10474399 104110215 CHEMBL496097 ZINC38933281 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413650 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(O)c(F)c1 InChI=1S/C19H17ClFN3O/c1-24-17(12-3-8-16(25)15(21)11-12)22-23-18(24)19(9-2-10-19)13-4-6-14(20)7-5-13/h3-8,11,25H,2,9-10H2,1H3 IHADCYYSVVNWIT-UHFFFAOYSA-N 50260794 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-2-fluorophenol::CHEMBL496096 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260794&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724919 104110214 CHEMBL496096 ZINC38824230 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413651 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl InChI=1S/C19H16Cl3N3/c1-25-17(15-8-7-14(21)11-16(15)22)23-24-18(25)19(9-2-10-19)12-3-5-13(20)6-4-12/h3-8,11H,2,9-10H2,1H3 WXIOFSFWRFRIPP-UHFFFAOYSA-N 50260793 3-(1-(4-chlorophenyl)cyclobutyl)-5-(2,4-dichlorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL496095 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260793&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724901 104110213 CHEMBL496095 ZINC40431152 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413652 COc1ccccc1-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C20H20ClN3O/c1-24-18(16-6-3-4-7-17(16)25-2)22-23-19(24)20(12-5-13-20)14-8-10-15(21)11-9-14/h3-4,6-11H,5,12-13H2,1-2H3 ZVHDYQKHKNEHDW-UHFFFAOYSA-N 50260749 3-(1-(4-chlorophenyl)cyclobutyl)-5-(2-methoxyphenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL525003 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260749&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10473292 104110183 CHEMBL525003 ZINC38930172 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413653 Cc1ccccc1-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C20H20ClN3/c1-14-6-3-4-7-17(14)18-22-23-19(24(18)2)20(12-5-13-20)15-8-10-16(21)11-9-15/h3-4,6-11H,5,12-13H2,1-2H3 BIRQMROLZMWVQO-UHFFFAOYSA-N 50260748 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-o-tolyl-4H-1,2,4-triazole::CHEMBL498352 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260748&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10315044 104110182 CHEMBL498352 ZINC38493463 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413654 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(I)cc1 InChI=1S/C19H17ClIN3/c1-24-17(13-3-9-16(21)10-4-13)22-23-18(24)19(11-2-12-19)14-5-7-15(20)8-6-14/h3-10H,2,11-12H2,1H3 CCIVUCGOJMDSLK-UHFFFAOYSA-N 50260747 3-(1-(4-chlorophenyl)cyclobutyl)-5-(4-iodophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL498351 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260747&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576672 104110181 CHEMBL498351 ZINC40424307 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413655 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1C(F)(F)F InChI=1S/C20H17ClF3N3/c1-27-17(15-5-2-3-6-16(15)20(22,23)24)25-26-18(27)19(11-4-12-19)13-7-9-14(21)10-8-13/h2-3,5-10H,4,11-12H2,1H3 UQVNBHWADMNPJM-UHFFFAOYSA-N 50260746 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL524824 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260746&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11741200 104110180 CHEMBL524824 ZINC36400453 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413656 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(F)(F)F InChI=1S/C20H17ClF3N3/c1-27-17(13-3-5-15(6-4-13)20(22,23)24)25-26-18(27)19(11-2-12-19)14-7-9-16(21)10-8-14/h3-10H,2,11-12H2,1H3 BTXMBHFNWIETNI-UHFFFAOYSA-N 50260745 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL498353 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260745&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724898 104110179 CHEMBL498353 ZINC40430352 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413657 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(F)c1 InChI=1S/C19H17ClFN3/c1-24-17(13-4-2-5-16(21)12-13)22-23-18(24)19(10-3-11-19)14-6-8-15(20)9-7-14/h2,4-9,12H,3,10-11H2,1H3 QIZUXQUFXCPBPX-UHFFFAOYSA-N 50260708 3-(1-(4-chlorophenyl)cyclobutyl)-5-(3-fluorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL496295 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260708&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724903 104110156 CHEMBL496295 ZINC40972933 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413658 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1F InChI=1S/C19H17ClFN3/c1-24-17(15-5-2-3-6-16(15)21)22-23-18(24)19(11-4-12-19)13-7-9-14(20)10-8-13/h2-3,5-10H,4,11-12H2,1H3 QWPFWVRPEFMTNO-UHFFFAOYSA-N 50260707 3-(1-(4-chlorophenyl)cyclobutyl)-5-(2-fluorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL496294 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260707&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10359991 104110155 CHEMBL496294 ZINC38617983 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413659 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(F)cc1 InChI=1S/C19H17ClFN3/c1-24-17(13-3-9-16(21)10-4-13)22-23-18(24)19(11-2-12-19)14-5-7-15(20)8-6-14/h3-10H,2,11-12H2,1H3 UYAYFLIYMDGFPR-UHFFFAOYSA-N 50260706 3-(1-(4-chlorophenyl)cyclobutyl)-5-(4-fluorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL508147 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260706&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576651 104110154 CHEMBL508147 ZINC40846272 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413660 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(Cl)c1 InChI=1S/C19H17Cl2N3/c1-24-17(13-4-2-5-16(21)12-13)22-23-18(24)19(10-3-11-19)14-6-8-15(20)9-7-14/h2,4-9,12H,3,10-11H2,1H3 NQHSJELQQVWZJD-UHFFFAOYSA-N 50260705 3-(3-chlorophenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL497951 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260705&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724912 104110153 CHEMBL497951 ZINC40424391 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413661 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1Cl InChI=1S/C19H17Cl2N3/c1-24-17(15-5-2-3-6-16(15)21)22-23-18(24)19(11-4-12-19)13-7-9-14(20)10-8-13/h2-3,5-10H,4,11-12H2,1H3 HSVNFDUPXHVBSA-UHFFFAOYSA-N 50260704 3-(2-chlorophenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL497748 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260704&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9998483 104110152 CHEMBL497748 ZINC03928058 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413662 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(Cl)cc1 InChI=1S/C19H17Cl2N3/c1-24-17(13-3-7-15(20)8-4-13)22-23-18(24)19(11-2-12-19)14-5-9-16(21)10-6-14/h3-10H,2,11-12H2,1H3 PWFIVVWXVGTAHD-UHFFFAOYSA-N 50260670 3-(4-chlorophenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL494819 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260670&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9975639 104110137 CHEMBL494819 ZINC40430566 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413663 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(OC(F)(F)F)c1 InChI=1S/C20H17ClF3N3O/c1-27-17(13-4-2-5-16(12-13)28-20(22,23)24)25-26-18(27)19(10-3-11-19)14-6-8-15(21)9-7-14/h2,4-9,12H,3,10-11H2,1H3 HZCDXSQWAXTCAH-UHFFFAOYSA-N 50260669 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(3-(trifluoromethoxy)phenyl)-4H-1,2,4-triazole::CHEMBL525606 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260669&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576637 104110136 CHEMBL525606 ZINC40425311 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413664 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1OC(F)(F)F InChI=1S/C20H17ClF3N3O/c1-27-17(15-5-2-3-6-16(15)28-20(22,23)24)25-26-18(27)19(11-4-12-19)13-7-9-14(21)10-8-13/h2-3,5-10H,4,11-12H2,1H3 JGPTYPUUBLBVQQ-UHFFFAOYSA-N 50260668 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(2-(trifluoromethoxy)phenyl)-4H-1,2,4-triazole::CHEMBL494809 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260668&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10250842 104110135 CHEMBL494809 ZINC40955656 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413665 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(OC(F)(F)F)cc1 InChI=1S/C20H17ClF3N3O/c1-27-17(13-3-9-16(10-4-13)28-20(22,23)24)25-26-18(27)19(11-2-12-19)14-5-7-15(21)8-6-14/h3-10H,2,11-12H2,1H3 ORACBUKRQCFDKX-UHFFFAOYSA-N 50260667 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(trifluoromethoxy)phenyl)-4H-1,2,4-triazole::CHEMBL522533 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260667&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11742158 104110134 CHEMBL522533 ZINC36401412 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413666 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(O)c1 InChI=1S/C19H18ClN3O/c1-23-17(13-4-2-5-16(24)12-13)21-22-18(23)19(10-3-11-19)14-6-8-15(20)9-7-14/h2,4-9,12,24H,3,10-11H2,1H3 PIMSKOVVWSNBGX-UHFFFAOYSA-N 50260666 3-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenol::CHEMBL521688 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260666&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576636 104110133 CHEMBL521688 ZINC40954587 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413667 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1O InChI=1S/C19H18ClN3O/c1-23-17(15-5-2-3-6-16(15)24)21-22-18(23)19(11-4-12-19)13-7-9-14(20)10-8-13/h2-3,5-10,24H,4,11-12H2,1H3 RXQRMKXPLSFHNN-UHFFFAOYSA-N 50260625 2-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenol::CHEMBL494206 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260625&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10246599 104110115 CHEMBL494206 ZINC38421937 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413668 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(O)cc1 InChI=1S/C19H18ClN3O/c1-23-17(13-3-9-16(24)10-4-13)21-22-18(23)19(11-2-12-19)14-5-7-15(20)8-6-14/h3-10,24H,2,11-12H2,1H3 WTQKKLLPYZOULB-UHFFFAOYSA-N 50260624 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenol::CHEMBL494180 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260624&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724920 104110114 CHEMBL494180 ZINC40952632 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50413669 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1 InChI=1S/C19H18ClN3/c1-23-17(14-6-3-2-4-7-14)21-22-18(23)19(12-5-13-19)15-8-10-16(20)11-9-15/h2-4,6-11H,5,12-13H2,1H3 AMRNFCHSNOKVDZ-UHFFFAOYSA-N 50260623 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-phenyl-4H-1,2,4-triazole::CHEMBL523177 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260623&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724899 104110113 CHEMBL523177 ZINC40425335 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631932 C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCCn12 InChI=1S/C18H27N3/c1-2-4-6-21-16(5-3-1)19-20-17(21)18-10-13-7-14(11-18)9-15(8-13)12-18/h13-15H,1-12H2 KTYRDCHIMJKQQH-UHFFFAOYSA-N 50340809 3-Adamantan-1-yl-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL256778 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340809&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10308303 131343745 CHEMBL256778 ZINC29045264 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631934 Clc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22ClN3/c19-15-9-7-14(8-10-15)18(11-5-12-18)17-21-20-16-6-3-1-2-4-13-22(16)17/h7-10H,1-6,11-13H2 FDLFGCPTRMXATH-UHFFFAOYSA-N 50239407 3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::3-[1-(4-Chloro-phenyl)-cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL257149 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239407&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10335880 104056508 CHEMBL257149 ZINC29044661 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631936 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1 InChI=1S/C19H18ClN3/c1-23-17(14-6-3-2-4-7-14)21-22-18(23)19(12-5-13-19)15-8-10-16(20)11-9-15/h2-4,6-11H,5,12-13H2,1H3 AMRNFCHSNOKVDZ-UHFFFAOYSA-N 50260623 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-phenyl-4H-1,2,4-triazole::CHEMBL523177 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260623&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724899 104110113 CHEMBL523177 ZINC40425335 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631938 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C25H22ClN3/c1-29-23(20-10-8-19(9-11-20)18-6-3-2-4-7-18)27-28-24(29)25(16-5-17-25)21-12-14-22(26)15-13-21/h2-4,6-15H,5,16-17H2,1H3 UXOKGMBZBAXMDM-UHFFFAOYSA-N 50260797 3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL525361 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260797&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10340916 104110217 CHEMBL525361 ZINC38558781 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631940 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(O)=O InChI=1S/C20H18ClN3O2/c1-24-17(13-3-5-14(6-4-13)18(25)26)22-23-19(24)20(11-2-12-20)15-7-9-16(21)10-8-15/h3-10H,2,11-12H2,1H3,(H,25,26) UQMHXMBURPDAGQ-UHFFFAOYSA-N 50340810 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzoic acid::CHEMBL1760671 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340810&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585028 131343746 CHEMBL1760671 ZINC71317746 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631952 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(N)=O InChI=1S/C20H19ClN4O/c1-25-18(14-5-3-13(4-6-14)17(22)26)23-24-19(25)20(11-2-12-20)15-7-9-16(21)10-8-15/h3-10H,2,11-12H2,1H3,(H2,22,26) MXXLRXZZQGJLCI-UHFFFAOYSA-N 50340811 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzamide::CHEMBL1760672 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340811&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580118 131343747 CHEMBL1760672 ZINC71329667 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631954 CCNC(=O)c1ccc(cc1)-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C22H23ClN4O/c1-3-24-20(28)16-7-5-15(6-8-16)19-25-26-21(27(19)2)22(13-4-14-22)17-9-11-18(23)12-10-17/h5-12H,3-4,13-14H2,1-2H3,(H,24,28) ODDNAPFVJHVOLT-UHFFFAOYSA-N 50340822 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-N-ethylbenzamide::CHEMBL1760673 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340822&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585029 131343758 CHEMBL1760673 ZINC71329189 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631956 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)NC(C)(C)C InChI=1S/C24H27ClN4O/c1-23(2,3)26-21(30)17-8-6-16(7-9-17)20-27-28-22(29(20)4)24(14-5-15-24)18-10-12-19(25)13-11-18/h6-13H,5,14-15H2,1-4H3,(H,26,30) KBPXVIBNWBHKIX-UHFFFAOYSA-N 50340823 CHEMBL1760674::N-tert-butyl-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340823&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581094 131343759 CHEMBL1760674 ZINC71317458 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631958 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)NC1CC1 InChI=1S/C23H23ClN4O/c1-28-20(15-3-5-16(6-4-15)21(29)25-19-11-12-19)26-27-22(28)23(13-2-14-23)17-7-9-18(24)10-8-17/h3-10,19H,2,11-14H2,1H3,(H,25,29) ZXLFWPREOVAREF-UHFFFAOYSA-N 50340824 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-N-cyclopropylbenzamide::CHEMBL1760675 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340824&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582134 131343760 CHEMBL1760675 ZINC71316040 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631960 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)NC1CCC1 InChI=1S/C24H25ClN4O/c1-29-21(16-6-8-17(9-7-16)22(30)26-20-4-2-5-20)27-28-23(29)24(14-3-15-24)18-10-12-19(25)13-11-18/h6-13,20H,2-5,14-15H2,1H3,(H,26,30) INFTUHKDVWAXHL-UHFFFAOYSA-N 50340825 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-N-cyclobutylbenzamide::CHEMBL1760676 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340825&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584081 131343761 CHEMBL1760676 ZINC71329278 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631962 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)N1CCC1 InChI=1S/C23H23ClN4O/c1-27-20(16-4-6-17(7-5-16)21(29)28-14-3-15-28)25-26-22(27)23(12-2-13-23)18-8-10-19(24)11-9-18/h4-11H,2-3,12-15H2,1H3 OYMOQCSFDUOSAA-UHFFFAOYSA-N 50340826 CHEMBL1760677::azetidin-1-yl(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)methanone 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340826&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582135 131343762 CHEMBL1760677 ZINC71330976 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631964 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)N1CCCC1 InChI=1S/C24H25ClN4O/c1-28-21(17-5-7-18(8-6-17)22(30)29-15-2-3-16-29)26-27-23(28)24(13-4-14-24)19-9-11-20(25)12-10-19/h5-12H,2-4,13-16H2,1H3 HNNUFGHXZACPCD-UHFFFAOYSA-N 50340827 (4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)(pyrrolidin-1-yl)methanone::CHEMBL1760678 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340827&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586966 131343763 CHEMBL1760678 ZINC71296388 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631966 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)N1CCOCC1 InChI=1S/C24H25ClN4O2/c1-28-21(17-3-5-18(6-4-17)22(30)29-13-15-31-16-14-29)26-27-23(28)24(11-2-12-24)19-7-9-20(25)10-8-19/h3-10H,2,11-16H2,1H3 TVALZOHSDGHVGI-UHFFFAOYSA-N 50340828 (4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)(morpholino)methanone::CHEMBL1760679 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340828&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583079 131343764 CHEMBL1760679 ZINC71318971 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631968 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)C(O)=O InChI=1S/C20H17Cl2N3O2/c1-25-17(15-8-3-12(18(26)27)11-16(15)22)23-24-19(25)20(9-2-10-20)13-4-6-14(21)7-5-13/h3-8,11H,2,9-10H2,1H3,(H,26,27) CXEOROMWHNWONF-UHFFFAOYSA-N 50340829 3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzoic acid::CHEMBL1760680 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340829&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586967 131343765 CHEMBL1760680 ZINC71318854 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631970 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)C(N)=O InChI=1S/C20H18Cl2N4O/c1-26-18(15-8-3-12(17(23)27)11-16(15)22)24-25-19(26)20(9-2-10-20)13-4-6-14(21)7-5-13/h3-8,11H,2,9-10H2,1H3,(H2,23,27) XRKNMGUUBWDXPL-UHFFFAOYSA-N 50340830 3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzamide::CHEMBL1760681 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340830&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581095 131343766 CHEMBL1760681 ZINC71315860 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631972 CC(=O)Nc1ccc(cc1)-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C21H21ClN4O/c1-14(27)23-18-10-4-15(5-11-18)19-24-25-20(26(19)2)21(12-3-13-21)16-6-8-17(22)9-7-16/h4-11H,3,12-13H2,1-2H3,(H,23,27) RTSUBSMHFCWFJT-UHFFFAOYSA-N 50340792 CHEMBL1760683::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340792&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585992 131343728 CHEMBL1760683 ZINC71296938 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631974 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(NC(=O)c2cnccn2)cc1 InChI=1S/C24H21ClN6O/c1-31-21(16-3-9-19(10-4-16)28-22(32)20-15-26-13-14-27-20)29-30-23(31)24(11-2-12-24)17-5-7-18(25)8-6-17/h3-10,13-15H,2,11-12H2,1H3,(H,28,32) KVYXNQKSZCVHLF-UHFFFAOYSA-N 50340793 CHEMBL1760684::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrazine-2-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340793&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585993 131343729 CHEMBL1760684 ZINC71329550 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631976 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(NC(=O)c2cccs2)cc1 InChI=1S/C24H21ClN4OS/c1-29-21(16-5-11-19(12-6-16)26-22(30)20-4-2-15-31-20)27-28-23(29)24(13-3-14-24)17-7-9-18(25)10-8-17/h2,4-12,15H,3,13-14H2,1H3,(H,26,30) VHQQNMOPJCVPFS-UHFFFAOYSA-N 50340794 CHEMBL1760685::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)thiophene-2-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340794&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585994 131343730 CHEMBL1760685 ZINC71329913 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631978 Cc1cc(C(=O)Nc2ccc(cc2)-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(C)o1 InChI=1S/C26H25ClN4O2/c1-16-15-22(17(2)33-16)24(32)28-21-11-5-18(6-12-21)23-29-30-25(31(23)3)26(13-4-14-26)19-7-9-20(27)10-8-19/h5-12,15H,4,13-14H2,1-3H3,(H,28,32) CGWGMYIJFORQBT-UHFFFAOYSA-N 50340795 CHEMBL1760686::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-2,5-dimethylfuran-3-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340795&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586968 131343731 CHEMBL1760686 ZINC71316710 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631980 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(NC(=O)c2ccno2)cc1 InChI=1S/C23H20ClN5O2/c1-29-20(15-3-9-18(10-4-15)26-21(30)19-11-14-25-31-19)27-28-22(29)23(12-2-13-23)16-5-7-17(24)8-6-16/h3-11,14H,2,12-13H2,1H3,(H,26,30) GYGISWPQEUFTKD-UHFFFAOYSA-N 50340796 CHEMBL1760687::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)isoxazole-5-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340796&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586969 131343732 CHEMBL1760687 ZINC71329653 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631982 CC(=O)Nc1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C21H20Cl2N4O/c1-13(28)24-16-8-9-17(18(23)12-16)19-25-26-20(27(19)2)21(10-3-11-21)14-4-6-15(22)7-5-14/h4-9,12H,3,10-11H2,1-2H3,(H,24,28) VTGIWYUUZDTUEM-UHFFFAOYSA-N 50340807 CHEMBL1760689::N-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340807&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583080 131343743 CHEMBL1760689 ZINC71319288 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631984 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(NC(=O)c2cnccn2)cc1Cl InChI=1S/C24H20Cl2N6O/c1-32-21(30-31-23(32)24(9-2-10-24)15-3-5-16(25)6-4-15)18-8-7-17(13-19(18)26)29-22(33)20-14-27-11-12-28-20/h3-8,11-14H,2,9-10H2,1H3,(H,29,33) KYSJDYIKEDDRFU-UHFFFAOYSA-N 50340808 CHEMBL1760690::N-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrazine-2-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340808&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585030 131343744 CHEMBL1760690 ZINC71316317 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631986 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cncnc1 InChI=1S/C23H20ClN5/c1-29-21(17-5-3-16(4-6-17)18-13-25-15-26-14-18)27-28-22(29)23(11-2-12-23)19-7-9-20(24)10-8-19/h3-10,13-15H,2,11-12H2,1H3 GDYZOSVGSBKPLL-UHFFFAOYSA-N 50340812 5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrimidine::CHEMBL1760691 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340812&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582137 131343748 CHEMBL1760691 ZINC71315861 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631988 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cnc(N)nc1 InChI=1S/C23H21ClN6/c1-30-20(16-5-3-15(4-6-16)17-13-26-22(25)27-14-17)28-29-21(30)23(11-2-12-23)18-7-9-19(24)10-8-18/h3-10,13-14H,2,11-12H2,1H3,(H2,25,26,27) QCWFVPXCLWDYJM-UHFFFAOYSA-N 50340813 5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrimidin-2-amine::CHEMBL1760791 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340813&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586030 131343749 CHEMBL1760791 ZINC71329982 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631990 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cnc(=O)[nH]c1 InChI=1S/C23H20ClN5O/c1-29-20(16-5-3-15(4-6-16)17-13-25-22(30)26-14-17)27-28-21(29)23(11-2-12-23)18-7-9-19(24)10-8-18/h3-10,13-14H,2,11-12H2,1H3,(H,25,26,30) CATBWTNVXOHMMB-UHFFFAOYSA-N 50340814 5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrimidin-2-ol::CHEMBL1760792 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340814&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583125 131343750 CHEMBL1760792 ZINC71296997 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631992 COc1ncc(-c2ccc(cc2)-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(OC)n1 InChI=1S/C25H24ClN5O2/c1-31-21(29-30-23(31)25(13-4-14-25)18-9-11-19(26)12-10-18)17-7-5-16(6-8-17)20-15-27-24(33-3)28-22(20)32-2/h5-12,15H,4,13-14H2,1-3H3 TYBKJRHHHDQHNG-UHFFFAOYSA-N 50340815 5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-2,4-dimethoxypyrimidine::CHEMBL1760793 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340815&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583126 131343751 CHEMBL1760793 ZINC71329555 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631994 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cnccn1 InChI=1S/C23H20ClN5/c1-29-21(17-5-3-16(4-6-17)20-15-25-13-14-26-20)27-28-22(29)23(11-2-12-23)18-7-9-19(24)10-8-18/h3-10,13-15H,2,11-12H2,1H3 PZAIZRLLCHXVBJ-UHFFFAOYSA-N 50340816 2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrazine::CHEMBL1760794 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340816&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584119 131343752 CHEMBL1760794 ZINC71318937 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631996 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cc(=O)[nH]cn1 InChI=1S/C23H20ClN5O/c1-29-21(16-5-3-15(4-6-16)19-13-20(30)26-14-25-19)27-28-22(29)23(11-2-12-23)17-7-9-18(24)10-8-17/h3-10,13-14H,2,11-12H2,1H3,(H,25,26,30) GLTVSVCSEZJLOH-UHFFFAOYSA-N 50340817 6-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrimidin-4-ol::CHEMBL1760795 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340817&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585052 131343753 CHEMBL1760795 ZINC71296411 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50631998 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccc(Cl)nn1 InChI=1S/C23H19Cl2N5/c1-30-21(16-5-3-15(4-6-16)19-11-12-20(25)27-26-19)28-29-22(30)23(13-2-14-23)17-7-9-18(24)10-8-17/h3-12H,2,13-14H2,1H3 VKCZFLMKNCMHFB-UHFFFAOYSA-N 50340818 3-chloro-6-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyridazine::CHEMBL1760796 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340818&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585053 131343754 CHEMBL1760796 ZINC71296889 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632000 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccc(N)nn1 InChI=1S/C23H21ClN6/c1-30-21(16-5-3-15(4-6-16)19-11-12-20(25)27-26-19)28-29-22(30)23(13-2-14-23)17-7-9-18(24)10-8-17/h3-12H,2,13-14H2,1H3,(H2,25,27) NTOCENJFNJYPRA-UHFFFAOYSA-N 50340819 6-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyridazin-3-amine::CHEMBL1760797 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340819&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583127 131343755 CHEMBL1760797 ZINC71317019 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632002 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cnoc1 InChI=1S/C22H19ClN4O/c1-27-20(16-5-3-15(4-6-16)17-13-24-28-14-17)25-26-21(27)22(11-2-12-22)18-7-9-19(23)10-8-18/h3-10,13-14H,2,11-12H2,1H3 JBFDRORHJJBVHA-UHFFFAOYSA-N 50340820 4-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)isoxazole::CHEMBL1760798 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340820&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586031 131343756 CHEMBL1760798 ZINC71296898 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632004 Cc1noc(C)c1-c1ccc(cc1)-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C24H23ClN4O/c1-15-21(16(2)30-28-15)17-5-7-18(8-6-17)22-26-27-23(29(22)3)24(13-4-14-24)19-9-11-20(25)12-10-19/h5-12H,4,13-14H2,1-3H3 ZDDWKCLVBKVFGA-UHFFFAOYSA-N 50340821 4-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-3,5-dimethylisoxazole::CHEMBL1760799 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340821&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583128 131343757 CHEMBL1760799 ZINC71315951 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632006 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccon1 InChI=1S/C22H19ClN4O/c1-27-20(16-5-3-15(4-6-16)19-11-14-28-26-19)24-25-21(27)22(12-2-13-22)17-7-9-18(23)10-8-17/h3-11,14H,2,12-13H2,1H3 WJBGLLMXJGXWLR-UHFFFAOYSA-N 50340797 3-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)isoxazole::CHEMBL1760800 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340797&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585054 131343733 CHEMBL1760800 ZINC71330965 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632008 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1cccnc1 InChI=1S/C24H20Cl2N4/c1-30-22(20-10-5-16(14-21(20)26)17-4-2-13-27-15-17)28-29-23(30)24(11-3-12-24)18-6-8-19(25)9-7-18/h2,4-10,13-15H,3,11-12H2,1H3 RAQAZKICFNGDBP-UHFFFAOYSA-N 50260908 3-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyridine::CHEMBL522701 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260908&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576846 104110257 CHEMBL522701 ZINC40430308 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632010 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1F)-c1cccnc1 InChI=1S/C24H20ClFN4/c1-30-22(20-10-5-16(14-21(20)26)17-4-2-13-27-15-17)28-29-23(30)24(11-3-12-24)18-6-8-19(25)9-7-18/h2,4-10,13-15H,3,11-12H2,1H3 PRPPOLVIRDINKM-UHFFFAOYSA-N 50340799 3-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-fluorophenyl)pyridine::CHEMBL1760802 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340799&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581137 131343735 CHEMBL1760802 ZINC71315894 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632012 COc1cc(ccc1-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1)-c1cccnc1 InChI=1S/C25H23ClN4O/c1-30-23(21-11-6-17(15-22(21)31-2)18-5-3-14-27-16-18)28-29-24(30)25(12-4-13-25)19-7-9-20(26)10-8-19/h3,5-11,14-16H,4,12-13H2,1-2H3 RBGKTPBXYABVOH-UHFFFAOYSA-N 50340800 3-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-methoxyphenyl)pyridine::CHEMBL1760803 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340800&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587012 131343736 CHEMBL1760803 ZINC71315878 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632014 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1O)-c1cccnc1 InChI=1S/C24H21ClN4O/c1-29-22(20-10-5-16(14-21(20)30)17-4-2-13-26-15-17)27-28-23(29)24(11-3-12-24)18-6-8-19(25)9-7-18/h2,4-10,13-15,30H,3,11-12H2,1H3 ZSTHUWVKZPCGCW-UHFFFAOYSA-N 50340801 2-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-5-(pyridin-3-yl)phenol::CHEMBL1760804 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340801&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581138 131343737 CHEMBL1760804 ZINC71318202 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632016 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1F)-c1cnccn1 InChI=1S/C23H19ClFN5/c1-30-21(18-8-3-15(13-19(18)25)20-14-26-11-12-27-20)28-29-22(30)23(9-2-10-23)16-4-6-17(24)7-5-16/h3-8,11-14H,2,9-10H2,1H3 PLKKSSJPSJWGPI-UHFFFAOYSA-N 50340802 2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-fluorophenyl)pyrazine::CHEMBL1760805 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340802&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584121 131343738 CHEMBL1760805 ZINC71330044 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630842 CC(O)CCCC12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C21H35N3O/c1-17(25)7-6-9-20-10-13-21(14-11-20,15-12-20)19-23-22-18-8-4-2-3-5-16-24(18)19/h17,25H,2-16H2,1H3 OYOODXKCWJLXMH-UHFFFAOYSA-N 50340383 5-(4-(5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)bicyclo[2.2.2]octan-1-yl)pentan-2-ol::CHEMBL1761135 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 190 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340383&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11484764 131343319 CHEMBL1761135 ZINC71318888 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632018 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1OC(F)F)-c1cnccn1 InChI=1S/C24H20ClF2N5O/c1-32-21(30-31-22(32)24(9-2-10-24)16-4-6-17(25)7-5-16)18-8-3-15(13-20(18)33-23(26)27)19-14-28-11-12-29-19/h3-8,11-14,23H,2,9-10H2,1H3 HJGWKHPIIUHDTI-UHFFFAOYSA-N 50340803 2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-(difluoromethoxy)phenyl)pyrazine::CHEMBL1760806 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340803&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584122 131343739 CHEMBL1760806 ZINC71317759 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632020 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1C(N)=O)-c1cnccn1 InChI=1S/C24H21ClN6O/c1-31-22(18-8-3-15(13-19(18)21(26)32)20-14-27-11-12-28-20)29-30-23(31)24(9-2-10-24)16-4-6-17(25)7-5-16/h3-8,11-14H,2,9-10H2,1H3,(H2,26,32) XASSWSVGUZPMFR-UHFFFAOYSA-N 50340804 2-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-5-(pyrazin-2-yl)benzamide::CHEMBL1760807 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340804&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580143 131343740 CHEMBL1760807 ZINC71317721 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632022 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1C(N)=O)C(N)=O InChI=1S/C21H20ClN5O2/c1-27-19(15-8-3-12(17(23)28)11-16(15)18(24)29)25-26-20(27)21(9-2-10-21)13-4-6-14(22)7-5-13/h3-8,11H,2,9-10H2,1H3,(H2,23,28)(H2,24,29) GDQHXKRHLIAGIA-UHFFFAOYSA-N 50340805 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)isophthalamide::CHEMBL1760808 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340805&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582164 131343741 CHEMBL1760808 ZINC71296487 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50632024 Cn1c(nnc1C1(CC(F)C1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1cnccn1 InChI=1S/C23H18Cl2FN5/c1-31-21(18-7-2-14(10-19(18)25)20-13-27-8-9-28-20)29-30-22(31)23(11-17(26)12-23)15-3-5-16(24)6-4-15/h2-10,13,17H,11-12H2,1H3 QYSSEJDAEHAKCS-UHFFFAOYSA-N 50340831 2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrazine::CHEMBL1760809 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340831&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580144 131343767 CHEMBL1760809 ZINC71296493 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630850 CCCCCC12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C21H35N3/c1-2-3-7-10-20-11-14-21(15-12-20,16-13-20)19-23-22-18-9-6-4-5-8-17-24(18)19/h2-17H2,1H3 HISKJZZJMYSEGO-UHFFFAOYSA-N 50174285 3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL200513 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 2100 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174285&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11771845 104060103 CHEMBL200513 ZINC06717978 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630856 CCCCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3/c1-3-4-7-10-21-11-14-22(15-12-21,16-13-21)20-28-27-19(29(20)2)17-8-5-6-9-18(17)23(24,25)26/h5-6,8-9H,3-4,7,10-16H2,1-2H3 VPHWCVUMWQOWOK-UHFFFAOYSA-N 50174281 4-methyl-3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL383352 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174281&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10250720 104060099 CHEMBL383352 ZINC28530985 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630857 CC(O)CCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O/c1-16(30)6-5-9-21-10-13-22(14-11-21,15-12-21)20-28-27-19(29(20)2)17-7-3-4-8-18(17)23(24,25)26/h3-4,7-8,16,30H,5-6,9-15H2,1-2H3 LWSUXLRGYIUHPP-UHFFFAOYSA-N 50340396 5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)pentan-2-ol::CHEMBL1761136 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340396&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20755103 131343332 CHEMBL1761136 ZINC71319263 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630858 CC(=O)CCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H28F3N3O/c1-16(30)6-5-9-21-10-13-22(14-11-21,15-12-21)20-28-27-19(29(20)2)17-7-3-4-8-18(17)23(24,25)26/h3-4,7-8H,5-6,9-15H2,1-2H3 JRXYXRZPMZCAIV-UHFFFAOYSA-N 50340394 5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)pentan-2-one::CHEMBL1761137 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340394&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9823394 131343330 CHEMBL1761137 ZINC03960658 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630859 CC(F)CCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H29F4N3/c1-16(24)6-5-9-21-10-13-22(14-11-21,15-12-21)20-29-28-19(30(20)2)17-7-3-4-8-18(17)23(25,26)27/h3-4,7-8,16H,5-6,9-15H2,1-2H3 ZTWDQFBBGCYGMR-UHFFFAOYSA-N 50340391 3-(4-(4-fluoropentyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761138 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340391&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586091 131343327 CHEMBL1761138 ZINC71316422 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630860 Cn1c(nnc1C12CCC(CCCC(C)(F)F)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C23H28F5N3/c1-20(24,25)8-5-9-21-10-13-22(14-11-21,15-12-21)19-30-29-18(31(19)2)16-6-3-4-7-17(16)23(26,27)28/h3-4,6-7H,5,8-15H2,1-2H3 RJDVDAPIQXMABK-UHFFFAOYSA-N 50340397 3-(4-(4,4-difluoropentyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761139 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340397&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582242 131343333 CHEMBL1761139 ZINC71329214 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630861 COCCCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O/c1-29-19(17-7-3-4-8-18(17)23(24,25)26)27-28-20(29)22-13-10-21(11-14-22,12-15-22)9-5-6-16-30-2/h3-4,7-8H,5-6,9-16H2,1-2H3 BQIIPZMTXFQIQG-UHFFFAOYSA-N 50340395 3-(4-(4-methoxybutyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761140 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340395&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583210 131343331 CHEMBL1761140 ZINC71319277 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630862 CCOCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C21H26F3N3O/c1-3-28-14-19-8-11-20(12-9-19,13-10-19)18-26-25-17(27(18)2)15-6-4-5-7-16(15)21(22,23)24/h4-7H,3,8-14H2,1-2H3 QAWPXQQBJVQBKE-UHFFFAOYSA-N 50340398 3-(4-(ethoxymethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761141 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340398&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580210 131343334 CHEMBL1761141 ZINC71329566 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630863 Cn1c(nnc1C12CCC(COc3ccc(Cl)cc3)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C25H25ClF3N3O/c1-32-21(19-4-2-3-5-20(19)25(27,28)29)30-31-22(32)24-13-10-23(11-14-24,12-15-24)16-33-18-8-6-17(26)7-9-18/h2-9H,10-16H2,1H3 UVDHSOZENUAPIZ-UHFFFAOYSA-N 50340389 3-(4-((4-chlorophenoxy)methyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761142 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340389&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587090 131343325 CHEMBL1761142 ZINC71329695 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630864 Cn1c(nnc1C12CCC(COc3ccc(cc3)S(C)(=O)=O)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C26H28F3N3O3S/c1-32-22(20-5-3-4-6-21(20)26(27,28)29)30-31-23(32)25-14-11-24(12-15-25,13-16-25)17-35-18-7-9-19(10-8-18)36(2,33)34/h3-10H,11-17H2,1-2H3 MUQZDSVVZOGCQZ-UHFFFAOYSA-N 50340399 4-methyl-3-(4-((4-(methylsulfonyl)phenoxy)methyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761143 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340399&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586092 131343335 CHEMBL1761143 ZINC71315866 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630865 Cn1c(nnc1C12CCC(CNS(C)(=O)=O)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C20H25F3N4O2S/c1-27-16(14-5-3-4-6-15(14)20(21,22)23)25-26-17(27)19-10-7-18(8-11-19,9-12-19)13-24-30(2,28)29/h3-6,24H,7-13H2,1-2H3 DFILCFKLBRQIOI-UHFFFAOYSA-N 50340387 CHEMBL1761144::N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)methanesulfonamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340387&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581213 131343323 CHEMBL1761144 ZINC71296922 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630866 CCS(=O)(=O)NCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C21H27F3N4O2S/c1-3-31(29,30)25-14-19-8-11-20(12-9-19,13-10-19)18-27-26-17(28(18)2)15-6-4-5-7-16(15)21(22,23)24/h4-7,25H,3,8-14H2,1-2H3 BOZUAKRAAYEOLG-UHFFFAOYSA-N 50340384 CHEMBL1761309::N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)ethanesulfonamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340384&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584196 131343320 CHEMBL1761309 ZINC71329581 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630867 CCCS(=O)(=O)NCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C22H29F3N4O2S/c1-3-14-32(30,31)26-15-20-8-11-21(12-9-20,13-10-20)19-28-27-18(29(19)2)16-6-4-5-7-17(16)22(23,24)25/h4-7,26H,3,8-15H2,1-2H3 CLPWJRQJAHLUQT-UHFFFAOYSA-N 50340380 CHEMBL1761310::N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)propane-1-sulfonamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340380&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582261 131343316 CHEMBL1761310 ZINC71317763 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630868 CCSCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C22H28F3N3S/c1-3-29-15-14-20-8-11-21(12-9-20,13-10-20)19-27-26-18(28(19)2)16-6-4-5-7-17(16)22(23,24)25/h4-7H,3,8-15H2,1-2H3 UAYZIYYBLXQLES-UHFFFAOYSA-N 50340400 3-(4-(2-(ethylthio)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761311 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340400&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587121 131343336 CHEMBL1761311 ZINC71330906 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630869 CCS(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C22H28F3N3OS/c1-3-30(29)15-14-20-8-11-21(12-9-20,13-10-20)19-27-26-18(28(19)2)16-6-4-5-7-17(16)22(23,24)25/h4-7H,3,8-15H2,1-2H3 HDJZSGDARWVVJV-UHFFFAOYSA-N 50340371 3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761312 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340371&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584197 131343307 CHEMBL1761312 ZINC71330779 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630870 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C22H28F3N3O2S/c1-3-31(29,30)15-14-20-8-11-21(12-9-20,13-10-20)19-27-26-18(28(19)2)16-6-4-5-7-17(16)22(23,24)25/h4-7H,3,8-15H2,1-2H3 ZQPJDHAUCVEXLU-UHFFFAOYSA-N 50340378 3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761313 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340378&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 22591709 131343314 CHEMBL1761313 ZINC43128373 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630871 Cn1c(nnc1C12CCC(CCS(C)(=O)=O)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C21H26F3N3O2S/c1-27-17(15-5-3-4-6-16(15)21(22,23)24)25-26-18(27)20-10-7-19(8-11-20,9-12-20)13-14-30(2,28)29/h3-6H,7-14H2,1-2H3 FZVYZFRWYBAMAX-UHFFFAOYSA-N 50340382 4-methyl-3-(4-(2-(methylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761314 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340382&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583231 131343318 CHEMBL1761314 ZINC71330669 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630872 CCCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O2S/c1-3-15-32(30,31)16-14-21-8-11-22(12-9-21,13-10-21)20-28-27-19(29(20)2)17-6-4-5-7-18(17)23(24,25)26/h4-7H,3,8-16H2,1-2H3 ZRWCLFICBXDDJY-UHFFFAOYSA-N 50340374 4-methyl-3-(4-(2-(propylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761315 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340374&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587122 131343310 CHEMBL1761315 ZINC71316649 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630873 CC(C)S(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O2S/c1-16(2)32(30,31)15-14-21-8-11-22(12-9-21,13-10-21)20-28-27-19(29(20)3)17-6-4-5-7-18(17)23(24,25)26/h4-7,16H,8-15H2,1-3H3 KGLIHOPUIXJEHX-UHFFFAOYSA-N 50340372 3-(4-(2-(isopropylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761316 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340372&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20755069 131343308 CHEMBL1761316 ZINC71329549 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630874 Cn1c(nnc1C12CCC(CCS(=O)(=O)C(C)(C)C)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C24H32F3N3O2S/c1-21(2,3)33(31,32)16-15-22-9-12-23(13-10-22,14-11-22)20-29-28-19(30(20)4)17-7-5-6-8-18(17)24(25,26)27/h5-8H,9-16H2,1-4H3 GHISAKGSVUVTIE-UHFFFAOYSA-N 50340375 3-(4-(2-(tert-butylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761317 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340375&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44197230 131343311 CHEMBL1761317 ZINC71330921 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630875 Cn1c(nnc1C12CCC(CCS(=O)(=O)c3ccccc3)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C26H28F3N3O2S/c1-32-22(20-9-5-6-10-21(20)26(27,28)29)30-31-23(32)25-14-11-24(12-15-25,13-16-25)17-18-35(33,34)19-7-3-2-4-8-19/h2-10H,11-18H2,1H3 JBDITXLBFFQSTN-UHFFFAOYSA-N 50340373 4-methyl-3-(4-(2-(phenylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761318 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340373&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583232 131343309 CHEMBL1761318 ZINC71316719 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630876 Cn1c(nnc1C12CCC(CCS(=O)(=O)c3ccc(F)cc3)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C26H27F4N3O2S/c1-33-22(20-4-2-3-5-21(20)26(28,29)30)31-32-23(33)25-13-10-24(11-14-25,12-15-25)16-17-36(34,35)19-8-6-18(27)7-9-19/h2-9H,10-17H2,1H3 MVGZKTAXQNUWOV-UHFFFAOYSA-N 50340376 3-(4-(2-(4-fluorophenylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1760014 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340376&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584415 131343312 CHEMBL1760014 ZINC71316288 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630877 Cn1c(nnc1C12CCC(CCS(=O)(=O)C(F)(F)F)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C21H23F6N3O2S/c1-30-16(14-4-2-3-5-15(14)20(22,23)24)28-29-17(30)19-9-6-18(7-10-19,8-11-19)12-13-33(31,32)21(25,26)27/h2-5H,6-13H2,1H3 SYOUVVMHXMQLMO-UHFFFAOYSA-N 50340377 4-methyl-3-(2-(trifluoromethyl)phenyl)-5-(4-(2-(trifluoromethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4H-1,2,4-triazole::CHEMBL1761319 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340377&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 22591726 131343313 CHEMBL1761319 ZINC71315953 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630878 Cn1c(nnc1C12CCC(CCS(=O)(=O)CC(F)(F)F)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C22H25F6N3O2S/c1-31-17(15-4-2-3-5-16(15)22(26,27)28)29-30-18(31)20-9-6-19(7-10-20,8-11-20)12-13-34(32,33)14-21(23,24)25/h2-5H,6-14H2,1H3 NVNIPOVLJBAUGM-UHFFFAOYSA-N 50340392 4-methyl-3-(4-(2-(2,2,2-trifluoroethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761320 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340392&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583233 131343328 CHEMBL1761320 ZINC71329696 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630879 CCS(=O)(=O)CC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C21H26F3N3O2S/c1-3-30(28,29)14-19-8-11-20(12-9-19,13-10-19)18-26-25-17(27(18)2)15-6-4-5-7-16(15)21(22,23)24/h4-7H,3,8-14H2,1-2H3 IIUAOVVCEISVLV-UHFFFAOYSA-N 50340386 3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761321 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340386&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44196869 131343322 CHEMBL1761321 ZINC71316756 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630880 CCS(=O)(=O)CCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O2S/c1-3-32(30,31)16-6-9-21-10-13-22(14-11-21,15-12-21)20-28-27-19(29(20)2)17-7-4-5-8-18(17)23(24,25)26/h4-5,7-8H,3,6,9-16H2,1-2H3 ORQZQBUNAMJFCY-UHFFFAOYSA-N 50340401 3-(4-(3-(ethylsulfonyl)propyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761322 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 22591684 131343337 CHEMBL1761322 ZINC03960659 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630881 CCS(=O)(=O)CCCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C24H32F3N3O2S/c1-3-33(31,32)17-7-6-10-22-11-14-23(15-12-22,16-13-22)21-29-28-20(30(21)2)18-8-4-5-9-19(18)24(25,26)27/h4-5,8-9H,3,6-7,10-17H2,1-2H3 OJOIZXGLYDYZSP-UHFFFAOYSA-N 50340402 3-(4-(4-(ethylsulfonyl)butyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761323 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340402&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587123 131343338 CHEMBL1761323 ZINC71330061 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630882 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2Cl)n1C InChI=1S/C21H28ClN3O2S/c1-3-28(26,27)15-14-20-8-11-21(12-9-20,13-10-20)19-24-23-18(25(19)2)16-6-4-5-7-17(16)22/h4-7H,3,8-15H2,1-2H3 UEVJSVSXEAWSIN-UHFFFAOYSA-N 50340379 3-(2-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761324 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340379&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582262 131343315 CHEMBL1761324 ZINC71319326 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630883 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2cccc(Cl)c2)n1C InChI=1S/C21H28ClN3O2S/c1-3-28(26,27)14-13-20-7-10-21(11-8-20,12-9-20)19-24-23-18(25(19)2)16-5-4-6-17(22)15-16/h4-6,15H,3,7-14H2,1-2H3 FDUGOQBNTQPANC-UHFFFAOYSA-N 50340390 3-(3-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761325 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340390&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580243 131343326 CHEMBL1761325 ZINC71316699 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630884 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccc(Cl)cc2)n1C InChI=1S/C21H28ClN3O2S/c1-3-28(26,27)15-14-20-8-11-21(12-9-20,13-10-20)19-24-23-18(25(19)2)16-4-6-17(22)7-5-16/h4-7H,3,8-15H2,1-2H3 ADLLAELRQCIVNK-UHFFFAOYSA-N 50340393 3-(4-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761326 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340393&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583234 131343329 CHEMBL1761326 ZINC71316374 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630885 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccc(O)cc2Cl)n1C InChI=1S/C21H28ClN3O3S/c1-3-29(27,28)13-12-20-6-9-21(10-7-20,11-8-20)19-24-23-18(25(19)2)16-5-4-15(26)14-17(16)22/h4-5,14,26H,3,6-13H2,1-2H3 DKVFLOAIDJATMS-UHFFFAOYSA-N 50340403 3-chloro-4-(5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazol-3-yl)phenol::CHEMBL1761327 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340403&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11201450 131343339 CHEMBL1761327 ZINC38359947 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630886 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2Br)n1C InChI=1S/C21H28BrN3O2S/c1-3-28(26,27)15-14-20-8-11-21(12-9-20,13-10-20)19-24-23-18(25(19)2)16-6-4-5-7-17(16)22/h4-7H,3,8-15H2,1-2H3 VRYRRYFFSYUFNW-UHFFFAOYSA-N 50340381 3-(2-bromophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761328 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340381&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587124 131343317 CHEMBL1761328 ZINC71316977 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630887 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C)n1C InChI=1S/C22H31N3O2S/c1-4-28(26,27)16-15-21-9-12-22(13-10-21,14-11-21)20-24-23-19(25(20)3)18-8-6-5-7-17(18)2/h5-8H,4,9-16H2,1-3H3 BRPRVVJRJMNSBE-UHFFFAOYSA-N 50340385 3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-o-tolyl-4H-1,2,4-triazole::CHEMBL1761329 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340385&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584198 131343321 CHEMBL1761329 ZINC71330680 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50630888 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2F)n1C InChI=1S/C21H28FN3O2S/c1-3-28(26,27)15-14-20-8-11-21(12-9-20,13-10-20)19-24-23-18(25(19)2)16-6-4-5-7-17(16)22/h4-7H,3,8-15H2,1-2H3 LOLPZHHJXGSPLZ-UHFFFAOYSA-N 50340388 3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-fluorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761330 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340388&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585157 131343324 CHEMBL1761330 ZINC71388881 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870389 C1CCC(CC1)(c1nnc2CCCCCCn12)c1ccccc1 InChI=1S/C20H27N3/c1-2-10-16-23-18(13-7-1)21-22-19(23)20(14-8-4-9-15-20)17-11-5-3-6-12-17/h3,5-6,11-12H,1-2,4,7-10,13-16H2 DFFWGGJNBZJCEH-UHFFFAOYSA-N 50377877 CHEMBL256571 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377877&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10403095 160856960 CHEMBL256571 ZINC29045258 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870396 Clc1ccc(c(Cl)c1)C1(CC1)c1nnc2CCCCCCn12 InChI=1S/C17H19Cl2N3/c18-12-6-7-13(14(19)11-12)17(8-9-17)16-21-20-15-5-3-1-2-4-10-22(15)16/h6-7,11H,1-5,8-10H2 RQEHKNLHGDPXDS-UHFFFAOYSA-N 50377884 CHEMBL403993 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377884&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11724534 160856967 CHEMBL403993 ZINC29044283 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870397 C1CC1(c1nnc2CCCCCCn12)c1ccccc1 InChI=1S/C17H21N3/c1-2-7-13-20-15(10-6-1)18-19-16(20)17(11-12-17)14-8-4-3-5-9-14/h3-5,8-9H,1-2,6-7,10-13H2 OFULOUJEJXONJP-UHFFFAOYSA-N 50377885 CHEMBL402995 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377885&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10355633 160856968 CHEMBL402995 ZINC29044479 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870398 Cc1cccc(c1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H25N3/c1-15-8-6-9-16(14-15)19(11-7-12-19)18-21-20-17-10-4-2-3-5-13-22(17)18/h6,8-9,14H,2-5,7,10-13H2,1H3 XSXASYVDBXMZSI-UHFFFAOYSA-N 50377866 CHEMBL257148 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377866&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10402262 160856949 CHEMBL257148 ZINC29044658 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870399 Fc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22FN3/c19-15-9-7-14(8-10-15)18(11-5-12-18)17-21-20-16-6-3-1-2-4-13-22(16)17/h7-10H,1-6,11-13H2 VUDAYPLDMBOUGX-UHFFFAOYSA-N 50377867 CHEMBL256514 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377867&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10470037 160856950 CHEMBL256514 ZINC29044806 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870400 Cc1ccc(cc1)C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C20H27N3/c1-16-9-11-17(12-10-16)20(13-5-6-14-20)19-22-21-18-8-4-2-3-7-15-23(18)19/h9-12H,2-8,13-15H2,1H3 QCBITCMHMMZFGC-UHFFFAOYSA-N 50377870 CHEMBL256515 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377870&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10357992 160856953 CHEMBL256515 ZINC29044808 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870401 Fc1ccc(cc1)C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C19H24FN3/c20-16-10-8-15(9-11-16)19(12-4-5-13-19)18-22-21-17-7-3-1-2-6-14-23(17)18/h8-11H,1-7,12-14H2 XGTBDMONMCJFFG-UHFFFAOYSA-N 50377873 CHEMBL402613 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377873&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10064183 160856956 CHEMBL402613 ZINC29044968 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870402 Cc1ccc(cc1)C1(CCCCC1)c1nnc2CCCCCCn12 InChI=1S/C21H29N3/c1-17-10-12-18(13-11-17)21(14-6-4-7-15-21)20-23-22-19-9-5-2-3-8-16-24(19)20/h10-13H,2-9,14-16H2,1H3 IMHUBBHLFGUOQY-UHFFFAOYSA-N 50377875 CHEMBL256090 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377875&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10381554 160856958 CHEMBL256090 ZINC29045104 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870405 C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCn12 InChI=1S/C17H25N3/c1-2-4-15-18-19-16(20(15)5-3-1)17-9-12-6-13(10-17)8-14(7-12)11-17/h12-14H,1-11H2 VFTQRHWULYJKCI-UHFFFAOYSA-N 50239401 3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine::CHEMBL256777::MERCK-544 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >10000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3630776 104056507 CHEMBL256777 ZINC05494877 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870420 FC1(F)CC(C1)(c1nnc(C2CC2)n1C1CC1)c1ccc(Cl)cc1 InChI=1S/C18H18ClF2N3/c19-13-5-3-12(4-6-13)17(9-18(20,21)10-17)16-23-22-15(11-1-2-11)24(16)14-7-8-14/h3-6,11,14H,1-2,7-10H2 CNSHOXCOEFBECD-UHFFFAOYSA-N 50377889 CHEMBL255260 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377889&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44448872 160856972 CHEMBL255260 ZINC29044277 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870421 F[C@H]1C[C@](C1)(c1nnc(C2CC2)n1C1CC1)c1ccc(Cl)cc1 InChI=1S/C18H19ClFN3/c19-13-5-3-12(4-6-13)18(9-14(20)10-18)17-22-21-16(11-1-2-11)23(17)15-7-8-15/h3-6,11,14-15H,1-2,7-10H2/t14-,18+ OGYZYOKAXYFLIU-UJKQEGAGSA-N 50377887 CHEMBL255259 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377887&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9797661 160856970 CHEMBL255259 ZINC03928057 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870422 F[C@H]1C[C@@](C1)(c1nnc(C2CC2)n1C1CC1)c1ccc(Cl)cc1 InChI=1S/C18H19ClFN3/c19-13-5-3-12(4-6-13)18(9-14(20)10-18)17-22-21-16(11-1-2-11)23(17)15-7-8-15/h3-6,11,14-15H,1-2,7-10H2/t14-,18- OGYZYOKAXYFLIU-PPUGGXLSSA-N 50377888 CHEMBL404095 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377888&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9797661 160856971 CHEMBL404095 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870470 Cc1ccc(cc1)C1(CC1)c1nnc2CCCCCCn12 InChI=1S/C18H23N3/c1-14-7-9-15(10-8-14)18(11-12-18)17-20-19-16-6-4-2-3-5-13-21(16)17/h7-10H,2-6,11-13H2,1H3 XPVLBRLPRNDVHD-UHFFFAOYSA-N 50377878 CHEMBL258447 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377878&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10446475 160856961 CHEMBL258447 ZINC29044472 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870471 Clc1ccc(cc1)C1(CC1)c1nnc2CCCCCCn12 InChI=1S/C17H20ClN3/c18-14-8-6-13(7-9-14)17(10-11-17)16-20-19-15-5-3-1-2-4-12-21(15)16/h6-9H,1-5,10-12H2 RWLLTYVPGSHWBD-UHFFFAOYSA-N 50377886 CHEMBL258446 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377886&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10357519 160856969 CHEMBL258446 ZINC29044469 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870472 FC(F)(F)c1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H22F3N3/c20-19(21,22)15-9-7-14(8-10-15)18(11-5-12-18)17-24-23-16-6-3-1-2-4-13-25(16)17/h7-10H,1-6,11-13H2 BPNAZBBPOPSBMO-UHFFFAOYSA-N 50377864 CHEMBL403201 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377864&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9975108 160856947 CHEMBL403201 ZINC29044475 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870473 FC(F)(F)c1ccccc1C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H22F3N3/c20-19(21,22)15-9-5-4-8-14(15)18(11-7-12-18)17-24-23-16-10-3-1-2-6-13-25(16)17/h4-5,8-9H,1-3,6-7,10-13H2 BHGXJGPTKFVTMQ-UHFFFAOYSA-N 50377879 CHEMBL258448 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377879&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10043410 160856962 CHEMBL258448 ZINC29044476 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870474 Cc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H25N3/c1-15-8-10-16(11-9-15)19(12-6-13-19)18-21-20-17-7-4-2-3-5-14-22(17)18/h8-11H,2-7,12-14H2,1H3 DIPILFAQLQBGGN-UHFFFAOYSA-N 50377865 CHEMBL404435 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377865&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10040176 160856948 CHEMBL404435 ZINC29044649 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870475 Cc1ccccc1C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H25N3/c1-15-9-5-6-10-16(15)19(12-8-13-19)18-21-20-17-11-4-2-3-7-14-22(17)18/h5-6,9-10H,2-4,7-8,11-14H2,1H3 UUUYGEMUTWIEJT-UHFFFAOYSA-N 50377880 CHEMBL404436 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377880&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10040175 160856963 CHEMBL404436 ZINC29044655 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870476 Clc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22ClN3/c19-15-9-7-14(8-10-15)18(11-5-12-18)17-21-20-16-6-3-1-2-4-13-22(16)17/h7-10H,1-6,11-13H2 FDLFGCPTRMXATH-UHFFFAOYSA-N 50239407 3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::3-[1-(4-Chloro-phenyl)-cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL257149 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239407&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10335880 104056508 CHEMBL257149 ZINC29044661 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870477 Fc1cccc(c1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22FN3/c19-15-8-5-7-14(13-15)18(10-6-11-18)17-21-20-16-9-3-1-2-4-12-22(16)17/h5,7-8,13H,1-4,6,9-12H2 GTBJZZJXCRWFER-UHFFFAOYSA-N 50377868 CHEMBL255660 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377868&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10447474 160856951 CHEMBL255660 ZINC29044803 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870478 Fc1ccccc1C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22FN3/c19-15-9-5-4-8-14(15)18(11-7-12-18)17-21-20-16-10-3-1-2-6-13-22(16)17/h4-5,8-9H,1-3,6-7,10-13H2 JHVLIEDMRZFYKF-UHFFFAOYSA-N 50377881 CHEMBL256720 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377881&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10380007 160856964 CHEMBL256720 ZINC29044814 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870479 C1CC(C1)(c1nnc2CCCCCCn12)c1ccccc1 InChI=1S/C18H23N3/c1-2-7-14-21-16(11-6-1)19-20-17(21)18(12-8-13-18)15-9-4-3-5-10-15/h3-5,9-10H,1-2,6-8,11-14H2 CXEWZZRORHISQU-UHFFFAOYSA-N 50377869 CHEMBL402552 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377869&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10446474 160856952 CHEMBL402552 ZINC29044811 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870480 Cc1cccc(c1)C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C20H27N3/c1-16-9-8-10-17(15-16)20(12-5-6-13-20)19-22-21-18-11-4-2-3-7-14-23(18)19/h8-10,15H,2-7,11-14H2,1H3 DTJZINRCDGOYGP-UHFFFAOYSA-N 50377882 CHEMBL255934 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377882&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11722880 160856965 CHEMBL255934 ZINC29044963 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870481 Oc1cccc(c1)C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C19H25N3O/c23-16-9-7-8-15(14-16)19(11-4-5-12-19)18-21-20-17-10-3-1-2-6-13-22(17)18/h7-9,14,23H,1-6,10-13H2 PJENSBSIAHHTHI-UHFFFAOYSA-N 50377871 CHEMBL257414 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377871&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10335644 160856954 CHEMBL257414 ZINC29044974 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870482 Fc1ccccc1C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C19H24FN3/c20-16-10-5-4-9-15(16)19(12-6-7-13-19)18-22-21-17-11-3-1-2-8-14-23(17)18/h4-5,9-10H,1-3,6-8,11-14H2 GEQGACGSKOJYFR-UHFFFAOYSA-N 50377883 CHEMBL256291 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377883&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10018475 160856966 CHEMBL256291 ZINC29045109 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870483 C1CCC(C1)(c1nnc2CCCCCCn12)c1ccccc1 InChI=1S/C19H25N3/c1-2-9-15-22-17(12-6-1)20-21-18(22)19(13-7-8-14-19)16-10-4-3-5-11-16/h3-5,10-11H,1-2,6-9,12-15H2 SRTPHHCUWHWGSZ-UHFFFAOYSA-N 50377874 CHEMBL402386 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377874&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10085885 160856957 CHEMBL402386 ZINC29045106 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870484 Clc1ccc(cc1)C1(CCCCC1)c1nnc2CCCCCCn12 InChI=1S/C20H26ClN3/c21-17-11-9-16(10-12-17)20(13-5-3-6-14-20)19-23-22-18-8-4-1-2-7-15-24(18)19/h9-12H,1-8,13-15H2 NWLFUNAYJKKBKR-UHFFFAOYSA-N 50377876 CHEMBL256292 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377876&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10360107 160856959 CHEMBL256292 ZINC29045115 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50870485 Fc1ccc(cc1)C1(CCCCC1)c1nnc2CCCCCCn12 InChI=1S/C20H26FN3/c21-17-11-9-16(10-12-17)20(13-5-3-6-14-20)19-23-22-18-8-4-1-2-7-15-24(18)19/h9-12H,1-8,13-15H2 LGWPMKUAOWIERK-UHFFFAOYSA-N 50377890 CHEMBL402387 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377890&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724870 160856973 CHEMBL402387 ZINC29045112 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50885038 Clc1cccc(c1)S(=O)(=O)NCc1ccc(cc1)C(=O)NC1CCCCCC1 InChI=1S/C21H25ClN2O3S/c22-18-6-5-9-20(14-18)28(26,27)23-15-16-10-12-17(13-11-16)21(25)24-19-7-3-1-2-4-8-19/h5-6,9-14,19,23H,1-4,7-8,15H2,(H,24,25) LVWCYWKEBPDQNM-UHFFFAOYSA-N 50297908 4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptylbenzamide::CHEMBL549600 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >10000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297908&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45270351 104139439 CHEMBL549600 ZINC43015081 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50885039 CN(C1CCCCCC1)C(=O)c1ccc(CNS(=O)(=O)c2cccc(Cl)c2)cc1 InChI=1S/C22H27ClN2O3S/c1-25(20-8-4-2-3-5-9-20)22(26)18-13-11-17(12-14-18)16-24-29(27,28)21-10-6-7-19(23)15-21/h6-7,10-15,20,24H,2-5,8-9,16H2,1H3 VZFUMZUWJFIKDW-UHFFFAOYSA-N 50297909 4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-methylbenzamide::CHEMBL552288 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >1000000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297909&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45271171 104139440 CHEMBL552288 ZINC43063079 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50885040 CCCN(C1CCCCCC1)C(=O)c1ccc(CNS(=O)(=O)c2cccc(Cl)c2)cc1 InChI=1S/C24H31ClN2O3S/c1-2-16-27(22-9-5-3-4-6-10-22)24(28)20-14-12-19(13-15-20)18-26-31(29,30)23-11-7-8-21(25)17-23/h7-8,11-15,17,22,26H,2-6,9-10,16,18H2,1H3 JQJJNQAWLYPCQI-UHFFFAOYSA-N 50297910 4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-propylbenzamide::CHEMBL551949 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >1000000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297910&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44250316 104139441 CHEMBL551949 ZINC43059321 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50885041 CCCCN(C1CCCCCC1)C(=O)c1ccc(CNS(=O)(=O)c2cccc(Cl)c2)cc1 InChI=1S/C25H33ClN2O3S/c1-2-3-17-28(23-10-6-4-5-7-11-23)25(29)21-15-13-20(14-16-21)19-27-32(30,31)24-12-8-9-22(26)18-24/h8-9,12-16,18,23,27H,2-7,10-11,17,19H2,1H3 ACFPACQQCZIIAG-UHFFFAOYSA-N 50297911 CHEMBL550065::N-butyl-4-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptylbenzamide 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >1000000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297911&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45271081 104139442 CHEMBL550065 ZINC43011737 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50885042 Clc1cccc(c1)S(=O)(=O)NCc1ccc(cc1)C(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C24H27ClN2O3S/c25-21-2-1-3-22(11-21)31(29,30)26-15-16-4-6-20(7-5-16)23(28)27-24-12-17-8-18(13-24)10-19(9-17)14-24/h1-7,11,17-19,26H,8-10,12-15H2,(H,27,28) DITSVKMBGPBFDL-UHFFFAOYSA-N 50297912 4-[(3-Chlorophenylsulfonamido)methyl]-N-(1-adamantyl)benzamide::CHEMBL559418 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >1000000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297912&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45269430 104139443 CHEMBL559418 ZINC43075629 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50885046 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CCC(O)=O InChI=1S/C34H50O7/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40)/t21-,23-,24-,27+,30+,31-,32-,33+,34+/m0/s1 OBZHEBDUNPOCJG-WBXJDKIVSA-N 50247012 3beta-O-Succinyl-18-beta-glycyrrhetinic acid::Carbenoxolone::US11660306, Example Carbeanoxolone 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 82 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247012&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CBO 636403 104102199 ZINC38407010 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50933111 Clc1ccc2NC(=O)N(CC3CCN(CC3)C(=O)N(C3CC3)C3CCCCC3)S(=O)(=O)c2c1 InChI=1S/C23H31ClN4O4S/c24-17-6-9-20-21(14-17)33(31,32)27(22(29)25-20)15-16-10-12-26(13-11-16)23(30)28(19-7-8-19)18-4-2-1-3-5-18/h6,9,14,16,18-19H,1-5,7-8,10-13,15H2,(H,25,29) IKIIZIZOUKJDOA-UHFFFAOYSA-N 50382819 CHEMBL2023584 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2012.02.095 10.7270/Q22F7PGX 22440625 Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382819&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70687773 160861902 CHEMBL2023584 ZINC84587720 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50933112 CN(C1CCCCCC1)C(=O)N1CCC(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)CC1 InChI=1S/C22H31ClN4O4S/c1-25(18-6-4-2-3-5-7-18)22(29)26-12-10-16(11-13-26)15-27-21(28)24-19-9-8-17(23)14-20(19)32(27,30)31/h8-9,14,16,18H,2-7,10-13,15H2,1H3,(H,24,28) DFUDUOPNHOXDIK-UHFFFAOYSA-N 50382820 CHEMBL2023585 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2012.02.095 10.7270/Q22F7PGX 22440625 Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382820&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70691963 160861903 CHEMBL2023585 ZINC84586884 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50933113 CN(C1C2CC3CC(C2)CC1C3)C(=O)N1CCC(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)CC1 InChI=1S/C25H33ClN4O4S/c1-28(23-18-9-16-8-17(11-18)12-19(23)10-16)25(32)29-6-4-15(5-7-29)14-30-24(31)27-21-3-2-20(26)13-22(21)35(30,33)34/h2-3,13,15-19,23H,4-12,14H2,1H3,(H,27,31) USEVDAWMSYMUKI-UHFFFAOYSA-N 50382822 CHEMBL2023587 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2012.02.095 10.7270/Q22F7PGX 22440625 Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382822&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70691964 160861905 CHEMBL2023587 ZINC84636006 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50933114 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CCC(O)=O InChI=1S/C34H50O7/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40)/t21-,23-,24-,27+,30+,31-,32-,33+,34+/m0/s1 OBZHEBDUNPOCJG-WBXJDKIVSA-N 50247012 3beta-O-Succinyl-18-beta-glycyrrhetinic acid::Carbenoxolone::US11660306, Example Carbeanoxolone 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 82 ChEMBL 10.1016/j.bmcl.2012.02.095 10.7270/Q22F7PGX 22440625 Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247012&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CBO 636403 104102199 ZINC38407010 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50937767 C[C@H](CC[C@H](O)C(C)=C)[C@H]1CC[C@]2([C@@H]3CC[C@@H]4[C@]5(C[C@@]35CC[C@]12C)CCC(=O)C4(C)C)C(O)=O InChI=1S/C30H46O4/c1-18(2)21(31)8-7-19(3)20-11-14-30(25(33)34)23-10-9-22-26(4,5)24(32)12-13-28(22)17-29(23,28)16-15-27(20,30)6/h19-23,31H,1,7-17H2,2-6H3,(H,33,34)/t19-,20-,21+,22+,23-,27-,28-,29+,30+/m1/s1 SYVTXPULSBCSAB-CMWTXFCNSA-N 50384886 CHEMBL2035568 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/np200831c 10.7270/Q27M090Q 22360639 Mpetga, JD; Shen, Y; Tane, P; Li, SF; He, HP; Wabo, HK; Tene, M; Leng, Y; Hao, XJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384886&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57408764 160863969 CHEMBL2035568 ZINC84723348 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50937768 C[C@H](CC[C@@H](O)C(C)(C)O)[C@H]1CC[C@]2([C@@H]3CC[C@@H]4[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O)C4(C)C)C(O)=O InChI=1S/C30H50O5/c1-18(7-10-23(32)26(4,5)35)19-11-14-30(24(33)34)21-9-8-20-25(2,3)22(31)12-13-28(20)17-29(21,28)16-15-27(19,30)6/h18-23,31-32,35H,7-17H2,1-6H3,(H,33,34)/t18-,19-,20+,21-,22+,23-,27-,28-,29+,30+/m1/s1 WDJQHANSLSJHNN-XEPWAXDFSA-N 50384887 CHEMBL2035569 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1021/np200831c 10.7270/Q27M090Q 22360639 Mpetga, JD; Shen, Y; Tane, P; Li, SF; He, HP; Wabo, HK; Tene, M; Leng, Y; Hao, XJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384887&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57408765 160863970 CHEMBL2035569 ZINC84724672 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50937769 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CCC(O)=O InChI=1S/C34H50O7/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40)/t21-,23-,24-,27+,30+,31-,32-,33+,34+/m0/s1 OBZHEBDUNPOCJG-WBXJDKIVSA-N 50247012 3beta-O-Succinyl-18-beta-glycyrrhetinic acid::Carbenoxolone::US11660306, Example Carbeanoxolone 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 206 ChEMBL 10.1021/np200831c 10.7270/Q27M090Q 22360639 Mpetga, JD; Shen, Y; Tane, P; Li, SF; He, HP; Wabo, HK; Tene, M; Leng, Y; Hao, XJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247012&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CBO 636403 104102199 ZINC38407010 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 51069773 C[C@@]12CCC[C@](C)([C@H]1CC[C@@]13C[C@H](CC[C@@H]21)C(=C)[C@@H]3O)C(O)=O InChI=1S/C20H30O3/c1-12-13-5-6-15-18(2)8-4-9-19(3,17(22)23)14(18)7-10-20(15,11-13)16(12)21/h13-16,21H,1,4-11H2,2-3H3,(H,22,23)/t13?,14-,15-,16-,18+,19+,20+/m0/s1 GVGJRXSJJHLPGZ-WOBUGCKXSA-N 50436986 CHEMBL2402444 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436986&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3036892 175449303 CHEMBL2402444 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 51069786 C[C@@]1(CO)CCC[C@@]2(C)[C@@H]3CC[C@H]4C[C@]3(C[C@]4(O)CO)CC[C@H]12 InChI=1S/C20H34O3/c1-17(12-21)7-3-8-18(2)15(17)6-9-19-10-14(4-5-16(18)19)20(23,11-19)13-22/h14-16,21-23H,3-13H2,1-2H3/t14?,15-,16+,17+,18-,19+,20+/m1/s1 VAKACABDOYKFHJ-IJNDJDAVSA-N 50436976 CHEMBL2402471 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >1000000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436976&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73356628 175449293 CHEMBL2402471 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 51069787 C[C@@]12CCC[C@](C)([C@H]1CC[C@@]13C[C@H](CC[C@@H]21)[C@@](O)(CO)C3)C(O)=O InChI=1S/C20H32O4/c1-17-7-3-8-18(2,16(22)23)14(17)6-9-19-10-13(4-5-15(17)19)20(24,11-19)12-21/h13-15,21,24H,3-12H2,1-2H3,(H,22,23)/t13?,14-,15-,17+,18+,19-,20-/m0/s1 MRBLTWPEPGRXQN-YXUREUGOSA-N 50436975 CHEMBL490353 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >1000000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436975&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 13994830 175449292 CHEMBL490353 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 51069788 C[C@@]1(CO)CCC[C@@]2(C)[C@@H]3CC[C@H]4C[C@]3(CC4=C)CC[C@H]12 InChI=1S/C20H32O/c1-14-11-20-10-7-16-18(2,13-21)8-4-9-19(16,3)17(20)6-5-15(14)12-20/h15-17,21H,1,4-13H2,2-3H3/t15?,16-,17+,18+,19-,20-/m1/s1 TUJQVRFWMWRMIO-LHYCJURKSA-N 50436974 CHEMBL512447 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >1000000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436974&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24883422 175449291 15416 CHEMBL512447 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 51069789 C[C@@]12CCC[C@](C)([C@H]1CC[C@@]13C[C@H](CC[C@@H]21)C(=C)C3)C(O)=O InChI=1S/C20H30O2/c1-13-11-20-10-7-15-18(2,16(20)6-5-14(13)12-20)8-4-9-19(15,3)17(21)22/h14-16H,1,4-12H2,2-3H3,(H,21,22)/t14?,15-,16-,18+,19+,20+/m0/s1 NIKHGUQULKYIGE-MHHCCDILSA-N 50370742 KAURENOIC ACID 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 500000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50370742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50370742&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3034087 160849844 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50751424 OC1CN(C1)C(=O)CC1(C2CC3CC1CC(C2)[C@H]3O)c1ccccc1 InChI=1S/C21H27NO3/c23-18-11-22(12-18)19(24)10-21(15-4-2-1-3-5-15)16-6-13-7-17(21)9-14(8-16)20(13)25/h1-5,13-14,16-18,20,23,25H,6-12H2/t13?,14?,16?,17?,20-,21? OAAZMUGLOXGVNH-QKVOFEMESA-N 50239606 CHEMBL4080667 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus 7900 ChEMBL 10.1021/acs.jmedchem.7b00211 10.7270/Q2DV1N23 28537398 Ye, XY; Chen, SY; Wu, S; Yoon, DS; Wang, H; Hong, Z; O'Connor, SP; Li, J; Li, JJ; Kennedy, LJ; Walker, SJ; Nayeem, A; Sheriff, S; Camac, DM; Ramamurthy, V; Morin, PE; Zebo, R; Taylor, JR; Morgan, NN; Ponticiello, RP; Harrity, T; Apedo, A; Golla, R; Seethala, R; Wang, M; Harper, TW; Sleczka, BG; He, B; Kirby, M; Leahy, DK; Li, J; Hanson, RL; Guo, Z; Li, YX; DiMarco, JD; Scaringe, R; Maxwell, B; Moulin, F; Barrish, JC; Gordon, DA; Robl, JA Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239606&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44449361 85715888 CHEMBL4080667 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50888241 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C[C@@H](O)[C@@H]2[C@H](CC[C@@]32C)C(C)=O)C1(C)C InChI=1S/C26H42O4/c1-15(27)17-8-12-26(7)22(17)18(29)14-20-24(5)11-10-21(30-16(2)28)23(3,4)19(24)9-13-25(20,26)6/h17-22,29H,8-14H2,1-7H3/t17-,18-,19+,20-,21+,22+,24+,25-,26-/m1/s1 MLAAWJXDCTXSPC-XGWMCFOASA-N 50267561 CHEMBL4084451 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >10000 ChEMBL 10.1016/j.ejmech.2017.04.059 10.7270/Q2CF9SK2 28458137 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267561&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137646794 104114371 ZINC40950770 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50888242 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C[C@@H](O)[C@@H]2[C@@H](O)CC[C@@]32C)C1(C)C InChI=1S/C24H40O4/c1-14(25)28-19-9-10-22(4)17(21(19,2)3)8-12-23(5)18(22)13-16(27)20-15(26)7-11-24(20,23)6/h15-20,26-27H,7-13H2,1-6H3/t15-,16+,17-,18+,19-,20-,22-,23+,24+/m0/s1 XATLHNQIRONEBQ-AIPFBEDTSA-N 50267560 CHEMBL4102864 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >10000 ChEMBL 10.1016/j.ejmech.2017.04.059 10.7270/Q2CF9SK2 28458137 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267560&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137656587 104114370 ZINC40423955 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50888243 C[C@@]12CCC[C@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C22H38O2/c1-19(2)16-8-12-22(5)17(20(16,3)11-9-18(19)24)13-15(23)14-7-6-10-21(14,22)4/h14-18,23-24H,6-13H2,1-5H3/t14-,15+,16-,17+,18-,20-,21+,22+/m0/s1 FTLULZAZAZATSH-CLIKDFRBSA-N 50267559 CHEMBL4102413 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >100000 ChEMBL 10.1016/j.ejmech.2017.04.059 10.7270/Q2CF9SK2 28458137 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267559&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137662211 104114369 ZINC49878286 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50888244 C[C@@]12CC[C@H](CO)[C@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C23H40O3/c1-20(2)16-7-11-22(4)17(21(16,3)9-8-18(20)26)12-15(25)19-14(13-24)6-10-23(19,22)5/h14-19,24-26H,6-13H2,1-5H3/t14-,15-,16+,17-,18+,19+,21+,22-,23-/m1/s1 RUCUMAJZZYCVKB-QABJIJTISA-N 50267558 CHEMBL4065535 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >10000 ChEMBL 10.1016/j.ejmech.2017.04.059 10.7270/Q2CF9SK2 28458137 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267558&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137632590 104114368 ZINC45496374 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3 50888245 CC(=O)[C@]1(O)CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C24H40O4/c1-14(25)24(28)12-11-23(6)19(24)15(26)13-17-21(4)9-8-18(27)20(2,3)16(21)7-10-22(17,23)5/h15-19,26-28H,7-13H2,1-6H3/t15-,16+,17-,18+,19+,21+,22-,23-,24-/m1/s1 NTGOOMPVIVWMNT-YGUNCSITSA-N 50267593 CHEMBL4059599 11-beta-hydroxysteroid dehydrogenase type 2 Mus musculus >10000 ChEMBL 10.1016/j.ejmech.2017.04.059 10.7270/Q2CF9SK2 28458137 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1409&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267593&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137635838 404858547 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPGALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELSPVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYIEHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRRCFLQNFFINHLLPRALRPGQHGPAPA 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_MOUSE P51661 Q91WK3