BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51036281 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(O)=O InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1 LPLVUJXQOOQHMX-QWBHMCJMSA-N 50185127 (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid::30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-beta-D-glucopyranosyluronic acid)-alpha-D-glucopyranosiduronic acid::CHEMBL441687::glycyrrhizic acid::glycyrrhizinic acid::glyzyrrhizin 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185127&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 14982 104069368 15939 CHEMBL441687 4688 C03033 ZINC96015174 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24691 CC(C)(Oc1ccccc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(O)=O InChI=1S/C21H27NO4/c1-20(2,26-16-6-4-3-5-7-16)18(23)22-17-14-8-13-9-15(17)12-21(10-13,11-14)19(24)25/h3-7,13-15,17H,8-12H2,1-2H3,(H,22,23)(H,24,25)/t13-,14+,15?,17+,21+/m0/s1 GIFJUNAMCWBYRP-ZXNQMZRGSA-N 13755 (1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)adamantane-1-carboxylic acid::adamantane ether 5 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 17000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13755&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646479 46514142 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24692 CC(C)(Oc1ccccc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(N)=O InChI=1S/C21H28N2O3/c1-20(2,26-16-6-4-3-5-7-16)19(25)23-17-14-8-13-9-15(17)12-21(10-13,11-14)18(22)24/h3-7,13-15,17H,8-12H2,1-2H3,(H2,22,24)(H,23,25)/t13-,14+,15?,17+,21+/m0/s1 WLCAEXHUFPSPGJ-ZXNQMZRGSA-N 13756 (1R,3R,4S,7S)-4-(2-methyl-2-phenoxypropanamido)adamantane-1-carboxamide::adamantane ether 6 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 23000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13756&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646480 46514143 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24693 CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(O)=O InChI=1S/C21H26ClNO4/c1-20(2,27-16-6-4-3-5-15(16)22)18(24)23-17-13-7-12-8-14(17)11-21(9-12,10-13)19(25)26/h3-6,12-14,17H,7-11H2,1-2H3,(H,23,24)(H,25,26)/t12-,13+,14?,17+,21+/m0/s1 UIIZCFCYQSHWAX-PRXKHIFWSA-N 13757 (1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropanamido]adamantane-1-carboxylic acid::adamantane ether 7 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1800 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13757&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646481 46514144 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24694 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(O)=O InChI=1S/C21H26ClNO4/c1-20(2,27-16-5-3-4-15(22)8-16)18(24)23-17-13-6-12-7-14(17)11-21(9-12,10-13)19(25)26/h3-5,8,12-14,17H,6-7,9-11H2,1-2H3,(H,23,24)(H,25,26)/t12-,13+,14?,17+,21+/m0/s1 CBUFQCLXNNQQNG-PRXKHIFWSA-N 13758 (1R,3R,4S,7S)-4-[2-(3-chlorophenoxy)-2-methylpropanamido]adamantane-1-carboxylic acid::adamantane ether 8 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3500 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13758&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646482 46514145 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24695 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(O)=O InChI=1S/C21H26ClNO4/c1-20(2,27-16-5-3-15(22)4-6-16)18(24)23-17-13-7-12-8-14(17)11-21(9-12,10-13)19(25)26/h3-6,12-14,17H,7-11H2,1-2H3,(H,23,24)(H,25,26)/t12-,13+,14?,17+,21+/m0/s1 QILGSQJABZWEBZ-PRXKHIFWSA-N 13759 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]adamantane-1-carboxylic acid::adamantane ether 9 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 30000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13759&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646483 46514146 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24696 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(N)=O InChI=1S/C21H27ClN2O3/c1-20(2,27-16-5-3-15(22)4-6-16)19(26)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)25/h3-6,12-14,17H,7-11H2,1-2H3,(H2,23,25)(H,24,26)/t12-,13+,14?,17+,21+/m0/s1 DMVIIJMQXBNBLF-PRXKHIFWSA-N 13760 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]adamantane-1-carboxamide::adamantane ether 10 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 12000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13760&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646484 46514147 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24697 COc1ccc(OC(C)(C)C(=O)N[C@H]2C3C[C@@H]4C[C@@H]2C[C@](C4)(C3)C(N)=O)cc1 InChI=1S/C22H30N2O4/c1-21(2,28-17-6-4-16(27-3)5-7-17)20(26)24-18-14-8-13-9-15(18)12-22(10-13,11-14)19(23)25/h4-7,13-15,18H,8-12H2,1-3H3,(H2,23,25)(H,24,26)/t13-,14+,15?,18+,22+/m0/s1 MNVKIDPRYUGTTG-HAKNXOCISA-N 13761 (1R,3R,4S,7S)-4-[2-(4-methoxyphenoxy)-2-methylpropanamido]adamantane-1-carboxamide::adamantane ether 15 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 18000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13761&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646485 46514148 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24698 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccc(cc1)C(O)=O InChI=1S/C29H33ClN2O5/c1-28(2,37-23-9-7-22(30)8-10-23)26(35)32-24-20-11-18-12-21(24)15-29(13-18,14-20)27(36)31-16-17-3-5-19(6-4-17)25(33)34/h3-10,18,20-21,24H,11-16H2,1-2H3,(H,31,36)(H,32,35)(H,33,34)/t18-,20+,21?,24+,29+/m0/s1 DCBFGNRLHATVPF-QTRCPRJISA-N 13762 4-({[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]adamantan-1-yl]formamido}methyl)benzoic acid::adamantane ether 16 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 20000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13762&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646486 46514149 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24699 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccc(cc1)C(=O)NS(C)(=O)=O InChI=1S/C30H36ClN3O6S/c1-29(2,40-24-10-8-23(31)9-11-24)27(36)33-25-21-12-19-13-22(25)16-30(14-19,15-21)28(37)32-17-18-4-6-20(7-5-18)26(35)34-41(3,38)39/h4-11,19,21-22,25H,12-17H2,1-3H3,(H,32,37)(H,33,36)(H,34,35)/t19-,21+,22?,25+,30+/m0/s1 FWQHBEAXEAYWHI-GKKRZKHLSA-N 13763 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-{[4-(methanesulfonylcarbamoyl)phenyl]methyl}adamantane-1-carboxamide::adamantane ether 17 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 50000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13763&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646487 46514150 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24700 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccc(cc1)-c1nnn[nH]1 InChI=1S/C29H33ClN6O3/c1-28(2,39-23-9-7-22(30)8-10-23)26(37)32-24-20-11-18-12-21(24)15-29(13-18,14-20)27(38)31-16-17-3-5-19(6-4-17)25-33-35-36-34-25/h3-10,18,20-21,24H,11-16H2,1-2H3,(H,31,38)(H,32,37)(H,33,34,35,36)/t18-,20+,21?,24+,29+/m0/s1 KGIDONLAXKMIKG-QTRCPRJISA-N 13764 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-{[4-(1H-1,2,3,4-tetrazol-5-yl)phenyl]methyl}adamantane-1-carboxamide::adamantane ether 18 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 26000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13764&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646488 46514151 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24701 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccc(cc1)S(N)(=O)=O InChI=1S/C28H34ClN3O5S/c1-27(2,37-22-7-5-21(29)6-8-22)25(33)32-24-19-11-18-12-20(24)15-28(13-18,14-19)26(34)31-16-17-3-9-23(10-4-17)38(30,35)36/h3-10,18-20,24H,11-16H2,1-2H3,(H,31,34)(H,32,33)(H2,30,35,36)/t18-,19+,20?,24+,28+/m0/s1 AGDRECLEKQYTNN-JCOWOXNLSA-N 13765 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-[(4-sulfamoylphenyl)methyl]adamantane-1-carboxamide::adamantane ether 19 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13765&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646489 46514152 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24702 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1cncs1 InChI=1S/C25H30ClN3O3S/c1-24(2,32-19-5-3-18(26)4-6-19)22(30)29-21-16-7-15-8-17(21)11-25(9-15,10-16)23(31)28-13-20-12-27-14-33-20/h3-6,12,14-17,21H,7-11,13H2,1-2H3,(H,28,31)(H,29,30)/t15-,16+,17?,21+,25+/m0/s1 IZDUDJSLGJQVDK-ILXNSQLQSA-N 13766 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-(1,3-thiazol-5-ylmethyl)adamantane-1-carboxamide::adamantane ether 20 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 13000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13766&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646490 46514153 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24703 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCc1ccncc1 InChI=1S/C27H32ClN3O3/c1-26(2,34-22-5-3-21(28)4-6-22)24(32)31-23-19-11-18-12-20(23)15-27(13-18,14-19)25(33)30-16-17-7-9-29-10-8-17/h3-10,18-20,23H,11-16H2,1-2H3,(H,30,33)(H,31,32)/t18-,19+,20?,23+,27+/m0/s1 ACTSGYPIYRZKBB-GKUJUCRCSA-N 13767 (1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide::adamantane ether 21 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 5300 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13767&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646491 46514154 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24704 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NCC(N)=O InChI=1S/C23H30ClN3O4/c1-22(2,31-17-5-3-16(24)4-6-17)20(29)27-19-14-7-13-8-15(19)11-23(9-13,10-14)21(30)26-12-18(25)28/h3-6,13-15,19H,7-12H2,1-2H3,(H2,25,28)(H,26,30)(H,27,29)/t13-,14+,15?,19+,23+/m0/s1 XFHOFUPMDXTOPP-KNZQEESGSA-N 13768 N-[(1R,2S,5R,7S)-5-[(carbamoylmethyl)carbamoyl]adamantan-2-yl]-2-(4-chlorophenoxy)-2-methylpropanamide::adamantane ether 22 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 20000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13768&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646492 46514155 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24705 CNC(=O)NC(=O)[C@@]12C[C@@H]3CC(C1)[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)[C@H](C3)C2 InChI=1S/C23H30ClN3O4/c1-22(2,31-17-6-4-16(24)5-7-17)19(28)26-18-14-8-13-9-15(18)12-23(10-13,11-14)20(29)27-21(30)25-3/h4-7,13-15,18H,8-12H2,1-3H3,(H,26,28)(H2,25,27,29,30)/t13-,14+,15?,18+,23+/m0/s1 RJTGWEXIFPHKQR-CEZVUSQFSA-N 13769 2-(4-chlorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-{[(methylcarbamoyl)amino]carbonyl}adamantan-2-yl]propanamide::adamantane ether 23 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 12000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13769&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646493 46514156 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24706 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](CO)(C3)C2 InChI=1S/C21H28ClNO3/c1-20(2,26-17-5-3-16(22)4-6-17)19(25)23-18-14-7-13-8-15(18)11-21(9-13,10-14)12-24/h3-6,13-15,18,24H,7-12H2,1-2H3,(H,23,25)/t13-,14+,15?,18+,21+/m0/s1 SPQSNGFEASBQGI-IVAVVDRHSA-N 13770 2-(4-chlorophenoxy)-N-[(1R,2S,5R,7S)-5-(hydroxymethyl)adamantan-2-yl]-2-methylpropanamide::adamantane ether 24 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 25000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13770&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646494 46514157 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24707 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](COCC(O)=O)(C3)C2 InChI=1S/C23H30ClNO5/c1-22(2,30-18-5-3-17(24)4-6-18)21(28)25-20-15-7-14-8-16(20)11-23(9-14,10-15)13-29-12-19(26)27/h3-6,14-16,20H,7-13H2,1-2H3,(H,25,28)(H,26,27)/t14-,15+,16?,20+,23+/m0/s1 ONHLADOANHWPPY-AXWDGYAMSA-N 13771 2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]adamantan-1-yl]methoxy}acetic acid::adamantane ether 25 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13771&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646495 46514158 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24708 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)c1nnn[nH]1 InChI=1S/C21H25ClFN5O2/c1-20(2,30-16-4-3-14(23)7-15(16)22)19(29)24-17-12-5-11-6-13(17)10-21(8-11,9-12)18-25-27-28-26-18/h3-4,7,11-13,17H,5-6,8-10H2,1-2H3,(H,24,29)(H,25,26,27,28)/t11-,12+,13?,17+,21+/m0/s1 SDLVFSDWSGBQTI-FEOKCCHMSA-N 13772 2-(2-chloro-4-fluorophenoxy)-2-methyl-N-[(1R,2S,5R,7S)-5-(1H-1,2,3,4-tetrazol-5-yl)adamantan-2-yl]propanamide::adamantane ether 26 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 550 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13772&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646496 46514159 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 24709 CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](C3)(C2)C(=O)NS(C)(=O)=O InChI=1S/C22H29ClN2O5S/c1-21(2,30-17-7-5-4-6-16(17)23)19(26)24-18-14-8-13-9-15(18)12-22(10-13,11-14)20(27)25-31(3,28)29/h4-7,13-15,18H,8-12H2,1-3H3,(H,24,26)(H,25,27)/t13-,14+,15?,18+,22+/m0/s1 DFKJAMPFYWCPQV-HAKNXOCISA-N 13773 (1R,3R,4S,7S)-4-[2-(2-chlorophenoxy)-2-methylpropanamido]-N-methanesulfonyladamantane-1-carboxamide::adamantane ether 27 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 580 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.10.074 10.7270/Q2W66J13 17110106 aid1797082 Patel, JR; Shuai, Q; Dinges, J; Winn, M; Pliushchev, M; Fung, S; Monzon, K; Chiou, W; Wang, J; Pan, L; Wagaw, S; Engstrom, K; Kerdesky, FA; Longenecker, K; Judge, R; Qin, W; Imade, HM; Stolarik, D; Beno, DW; Brune, M; Chovan, LE; Sham, HL; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13773&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23646497 46514160 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40758 CCC1(C)SC(NC2CCCCCC2)=NC1=O InChI=1S/C13H22N2OS/c1-3-13(2)11(16)15-12(17-13)14-10-8-6-4-5-7-9-10/h10H,3-9H2,1-2H3,(H,14,15,16) BCGPLZDZWSCWQN-UHFFFAOYSA-N 22456 2-(cycloheptylamino)-5-ethyl-5-methyl-4,5-dihydro-1,3-thiazol-4-one::2-Amino-1,3-thiazol-4(5H)-one, 5c 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22456&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24825460 49846270 ZINC14978710 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40759 CCCC1(C)SC(NC2CCCCCC2)=NC1=O InChI=1S/C14H24N2OS/c1-3-10-14(2)12(17)16-13(18-14)15-11-8-6-4-5-7-9-11/h11H,3-10H2,1-2H3,(H,15,16,17) PQXVEAATFKMFDU-UHFFFAOYSA-N 22457 2-(cycloheptylamino)-5-methyl-5-propyl-4,5-dihydro-1,3-thiazol-4-one::2-Amino-1,3-thiazol-4(5H)-one, 6c 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22457&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24825461 49846271 ZINC14978716 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40760 CCC1(C)SC(NC2CCCCCCC2)=NC1=O InChI=1S/C14H24N2OS/c1-3-14(2)12(17)16-13(18-14)15-11-9-7-5-4-6-8-10-11/h11H,3-10H2,1-2H3,(H,15,16,17) YRMKTQIBOUAZCQ-UHFFFAOYSA-N 22458 2-(cyclooctylamino)-5-ethyl-5-methyl-4,5-dihydro-1,3-thiazol-4-one::2-Amino-1,3-thiazol-4(5H)-one, 5d 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22458&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24825462 49846272 ZINC14978721 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40761 CCCC1(C)SC(NC2CCCCCCC2)=NC1=O InChI=1S/C15H26N2OS/c1-3-11-15(2)13(18)17-14(19-15)16-12-9-7-5-4-6-8-10-12/h12H,3-11H2,1-2H3,(H,16,17,18) SBTHYUAUBLEDJY-UHFFFAOYSA-N 22459 2-(cyclooctylamino)-5-methyl-5-propyl-4,5-dihydro-1,3-thiazol-4-one::2-Amino-1,3-thiazol-4(5H)-one, 6d 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22459&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search H11 24825463 49846273 ZINC14978727 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40762 CCC1(C)SC(NC23CCC(CC2)C3)=NC1=O InChI=1S/C13H20N2OS/c1-3-12(2)10(16)14-11(17-12)15-13-6-4-9(8-13)5-7-13/h9H,3-8H2,1-2H3,(H,14,15,16) GJACSEPSTCDTAA-UHFFFAOYSA-N 22462 2-Amino-1,3-thiazol-4(5H)-one, 5f::2-{bicyclo[2.2.1]heptan-1-ylamino}-5-ethyl-5-methyl-4,5-dihydro-1,3-thiazol-4-one 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22462&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24825466 49846276 ZINC14978742 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40763 CCCC1(C)SC(NC2C3CCC2CC3)=NC1=O InChI=1S/C14H22N2OS/c1-3-8-14(2)12(17)16-13(18-14)15-11-9-4-5-10(11)7-6-9/h9-11H,3-8H2,1-2H3,(H,15,16,17) COIJIICCCMYJIE-UHFFFAOYSA-N 22465 2-Amino-1,3-thiazol-4(5H)-one, 6g::2-{bicyclo[2.2.1]heptan-7-ylamino}-5-methyl-5-propyl-4,5-dihydro-1,3-thiazol-4-one 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22465&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24825469 49846279 ZINC14978757 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40764 CCC1(C)SC(NC23CC4CC2CC(C3)C4)=NC1=O InChI=1S/C15H22N2OS/c1-3-14(2)12(18)16-13(19-14)17-15-7-9-4-10(8-15)6-11(15)5-9/h9-11H,3-8H2,1-2H3,(H,16,17,18) NKXZODWCNYSDGW-UHFFFAOYSA-N 22466 2-Amino-1,3-thiazol-4(5H)-one, 5h::5-ethyl-5-methyl-2-{tricyclo[3.3.1.0^{3,7}]nonan-3-ylamino}-4,5-dihydro-1,3-thiazol-4-one 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22466&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24825470 49846280 ZINC14978763 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40765 CCC1(CC)SC(NC2CCCCCCC2)=NC1=O InChI=1S/C15H26N2OS/c1-3-15(4-2)13(18)17-14(19-15)16-12-10-8-6-5-7-9-11-12/h12H,3-11H2,1-2H3,(H,16,17,18) RRKMMOVWARNROX-UHFFFAOYSA-N 22470 2-(cyclooctylamino)-5,5-diethyl-4,5-dihydro-1,3-thiazol-4-one::2-Amino-1,3-thiazol-4(5H)-one, 7a 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22470&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24825474 49846284 ZINC14978783 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40766 O=C1N=C(NC2CCCCCCC2)SC11CCCC1 InChI=1S/C15H24N2OS/c18-13-15(10-6-7-11-15)19-14(17-13)16-12-8-4-2-1-3-5-9-12/h12H,1-11H2,(H,16,17,18) JRXIMHQYNOCOAW-UHFFFAOYSA-N 22471 2-(cyclooctylamino)-1-thia-3-azaspiro[4.4]non-2-en-4-one::2-Amino-1,3-thiazol-4(5H)-one, 8a 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22471&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11507428 49846285 ZINC14978785 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40767 CCC1(CC)SC(NC23CC4CC2CC(C3)C4)=NC1=O InChI=1S/C16H24N2OS/c1-3-16(4-2)13(19)17-14(20-16)18-15-8-10-5-11(9-15)7-12(15)6-10/h10-12H,3-9H2,1-2H3,(H,17,18,19) AMSJQALMTUAGIU-UHFFFAOYSA-N 22472 2-Amino-1,3-thiazol-4(5H)-one, 7b::5,5-diethyl-2-{tricyclo[3.3.1.0^{3,7}]nonan-3-ylamino}-4,5-dihydro-1,3-thiazol-4-one 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22472&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24825475 49846286 ZINC14978791 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 40768 O=C1N=C(NC23CC4CC2CC(C3)C4)SC11CCCC1 InChI=1S/C16H22N2OS/c19-13-16(3-1-2-4-16)20-14(17-13)18-15-8-10-5-11(9-15)7-12(15)6-10/h10-12H,1-9H2,(H,17,18,19) GXHSOLWRHSMNFU-UHFFFAOYSA-N 22473 2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1-thia-3-azaspiro[4.4]non-2-en-4-one::2-Amino-1,3-thiazol-4(5H)-one, 8b::2-{tricyclo[3.3.1.0^{3,7}]nonan-3-ylamino}-1-thia-3-azaspiro[4.4]non-2-en-4-one 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 Curated from the literature by BindingDB 10.1021/jm701551j 10.7270/Q2HM56Q8 18419108 aid1798197 Johansson, L; Fotsch, C; Bartberger, MD; Castro, VM; Chen, M; Emery, M; Gustafsson, S; Hale, C; Hickman, D; Homan, E; Jordan, SR; Komorowski, R; Li, A; McRae, K; Moniz, G; Matsumoto, G; Orihuela, C; Palm, G; Veniant, M; Wang, M; Williams, M; Zhang, J Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22473&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24825476 49846287 ZINC14978797 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 54373 Clc1ccc(cc1)C1(CC1)C(=O)N1CCC2(CCc3ccccc23)C1 InChI=1S/C22H22ClNO/c23-18-7-5-17(6-8-18)22(11-12-22)20(25)24-14-13-21(15-24)10-9-16-3-1-2-4-19(16)21/h1-8H,9-15H2 IZOFFRWQNSMOTN-UHFFFAOYSA-N 29830 spiro-carboxamide scaffold, 3 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 7.8 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.02.123 10.7270/Q2X065DQ 19450980 aid1799040 Lepifre, F; Christmann-Franck, S; Roche, D; Leriche, C; Carniato, D; Charon, C; Bozec, S; Doare, L; Schmidlin, F; Lecomte, M; Valeur, E Merck Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29830&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44143289 85147594 ZINC56834458 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 54374 Clc1ccc(cc1)C1(CC1)C(=O)N1CCC2(C1)CCCc1ccccc21 InChI=1S/C23H24ClNO/c24-19-9-7-18(8-10-19)23(12-13-23)21(26)25-15-14-22(16-25)11-3-5-17-4-1-2-6-20(17)22/h1-2,4,6-10H,3,5,11-16H2 VVKFKQIRBWHKSV-UHFFFAOYSA-N 29832 spiro-carboxamide scaffold, 5 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 7.8 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.02.123 10.7270/Q2X065DQ 19450980 aid1799040 Lepifre, F; Christmann-Franck, S; Roche, D; Leriche, C; Carniato, D; Charon, C; Bozec, S; Doare, L; Schmidlin, F; Lecomte, M; Valeur, E Merck Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29832&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44143291 85147596 ZINC43020546 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 54375 Clc1ccc(cc1)C1(CC1)C(=O)N1CCC2(C1)CCCCC2 InChI=1S/C19H24ClNO/c20-16-6-4-15(5-7-16)19(10-11-19)17(22)21-13-12-18(14-21)8-2-1-3-9-18/h4-7H,1-3,8-14H2 UOBYXIKHZYUUHD-UHFFFAOYSA-N 29833 spiro-carboxamide scaffold, 6 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 7.8 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.02.123 10.7270/Q2X065DQ 19450980 aid1799040 Lepifre, F; Christmann-Franck, S; Roche, D; Leriche, C; Carniato, D; Charon, C; Bozec, S; Doare, L; Schmidlin, F; Lecomte, M; Valeur, E Merck Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29833&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44143292 85147597 ZINC43020838 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 54376 O=C(N1CCC2(C1)CCCCC2)C1(CC1)c1ccccc1 InChI=1S/C19H25NO/c21-17(19(11-12-19)16-7-3-1-4-8-16)20-14-13-18(15-20)9-5-2-6-10-18/h1,3-4,7-8H,2,5-6,9-15H2 KYTGICHJQRECNO-UHFFFAOYSA-N 29840 spiro-carboxamide scaffold, 13 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 7.8 22.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2009.02.123 10.7270/Q2X065DQ 19450980 aid1799040 Lepifre, F; Christmann-Franck, S; Roche, D; Leriche, C; Carniato, D; Charon, C; Bozec, S; Doare, L; Schmidlin, F; Lecomte, M; Valeur, E Merck Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29840&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44143299 85147604 ZINC43120691 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311145 CC(C)(C)OC(=O)N1CCCN(CC(=O)NC2C3CC4CC(C3)CC2C4)S1(=O)=O InChI=1S/C20H33N3O5S/c1-20(2,3)28-19(25)23-6-4-5-22(29(23,26)27)12-17(24)21-18-15-8-13-7-14(10-15)11-16(18)9-13/h13-16,18H,4-12H2,1-3H3,(H,21,24) ZNXQLJCFXDOQIJ-UHFFFAOYSA-N 50384526 CHEMBL2036421::US9073906, 3 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384526&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70675029 160863609 CHEMBL2036421 ZINC84670887 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311146 O=C(CN1CCCN(Cc2ccccc2)S1(=O)=O)NC1C2CC3CC(C2)CC1C3 InChI=1S/C22H31N3O3S/c26-21(23-22-19-10-17-9-18(12-19)13-20(22)11-17)15-25-8-4-7-24(29(25,27)28)14-16-5-2-1-3-6-16/h1-3,5-6,17-20,22H,4,7-15H2,(H,23,26) BGJHQUREHGHRIG-UHFFFAOYSA-N 50384527 CHEMBL2036422::US9073906, 5 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384527&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70675030 160863610 CHEMBL2036422 ZINC84670888 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311147 Fc1ccccc1CN1CCCN(CC(=O)NC2C3CC4CC(C3)CC2C4)S1(=O)=O InChI=1S/C22H30FN3O3S/c23-20-5-2-1-4-17(20)13-25-6-3-7-26(30(25,28)29)14-21(27)24-22-18-9-15-8-16(11-18)12-19(22)10-15/h1-2,4-5,15-16,18-19,22H,3,6-14H2,(H,24,27) UZDOEOGMTVJEPX-UHFFFAOYSA-N 167432 US9073906, 14 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167432&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70675143 312321278 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311148 O=C(CN1CCCN(c2ccccc2)S1(=O)=O)NC1C2CC3CC(C2)CC1C3 InChI=1S/C21H29N3O3S/c25-20(22-21-17-10-15-9-16(12-17)13-18(21)11-15)14-23-7-4-8-24(28(23,26)27)19-5-2-1-3-6-19/h1-3,5-6,15-18,21H,4,7-14H2,(H,22,25) ZAUYHZNEANFCTP-UHFFFAOYSA-N 50384529 CHEMBL2036424::US9073906, 2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384529&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70675028 160863612 CHEMBL2036424 ZINC84670891 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311149 Cc1ccc(cc1)N1CCCN(CC(=O)NC2C3CC4CC(C3)CC2C4)S1(=O)=O InChI=1S/C22H31N3O3S/c1-15-3-5-20(6-4-15)25-8-2-7-24(29(25,27)28)14-21(26)23-22-18-10-16-9-17(12-18)13-19(22)11-16/h3-6,16-19,22H,2,7-14H2,1H3,(H,23,26) WMHFKNCMSQXCKI-UHFFFAOYSA-N 167433 US9073906, 24 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167433&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 89926826 312321279 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311150 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4ccccc4)S1(=O)=O)C(C3)C2 InChI=1S/C22H30N4O4S/c23-21(28)22-11-15-9-16(12-22)20(17(10-15)13-22)24-19(27)14-25-7-4-8-26(31(25,29)30)18-5-2-1-3-6-18/h1-3,5-6,15-17,20H,4,7-14H2,(H2,23,28)(H,24,27) NSYFXAYYJBCHBD-UHFFFAOYSA-N 167436 US9073906, 60 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167436&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70690164 312321282 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311151 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4ccccc4F)S1(=O)=O)C(C3)C2 InChI=1S/C22H29FN4O4S/c23-17-4-1-2-5-18(17)27-7-3-6-26(32(27,30)31)13-19(28)25-20-15-8-14-9-16(20)12-22(10-14,11-15)21(24)29/h1-2,4-5,14-16,20H,3,6-13H2,(H2,24,29)(H,25,28) BYJASLAKCTVSFW-UHFFFAOYSA-N 167435 US9073906, 59 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167435&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70675400 312321281 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311152 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4cccc(F)c4)S1(=O)=O)C(C3)C2 InChI=1S/C22H29FN4O4S/c23-17-3-1-4-18(9-17)27-6-2-5-26(32(27,30)31)13-19(28)25-20-15-7-14-8-16(20)12-22(10-14,11-15)21(24)29/h1,3-4,9,14-16,20H,2,5-8,10-13H2,(H2,24,29)(H,25,28) PMVWZRYZHFOQRV-UHFFFAOYSA-N 167437 US9073906, 69 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167437&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70688132 312321283 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311153 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4ccc(F)cc4)S1(=O)=O)C(C3)C2 InChI=1S/C22H29FN4O4S/c23-17-2-4-18(5-3-17)27-7-1-6-26(32(27,30)31)13-19(28)25-20-15-8-14-9-16(20)12-22(10-14,11-15)21(24)29/h2-5,14-16,20H,1,6-13H2,(H2,24,29)(H,25,28) IYLBQFGHHLIWRY-UHFFFAOYSA-N 167434 US9073906, 44 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167434&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70683862 312321280 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311154 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4c(F)cc(F)cc4F)S1(=O)=O)C(C3)C2 InChI=1S/C22H27F3N4O4S/c23-15-6-16(24)20(17(25)7-15)29-3-1-2-28(34(29,32)33)11-18(30)27-19-13-4-12-5-14(19)10-22(8-12,9-13)21(26)31/h6-7,12-14,19H,1-5,8-11H2,(H2,26,31)(H,27,30) FSDWGADVUJNNKE-UHFFFAOYSA-N 167439 US9073906, 89 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167439&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70674215 312321285 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311155 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 InChI=1S/C22H27Cl3N4O4S/c23-15-6-16(24)20(17(25)7-15)29-3-1-2-28(34(29,32)33)11-18(30)27-19-13-4-12-5-14(19)10-22(8-12,9-13)21(26)31/h6-7,12-14,19H,1-5,8-11H2,(H2,26,31)(H,27,30) LZIPVWJWTGYZSZ-UHFFFAOYSA-N 167438 US9073906, 88 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167438&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70681752 312321284 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311156 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 InChI=1S/C21H25Cl3N4O4S/c22-14-5-15(23)19(16(24)6-14)28-2-1-27(33(28,31)32)10-17(29)26-18-12-3-11-4-13(18)9-21(7-11,8-12)20(25)30/h5-6,11-13,18H,1-4,7-10H2,(H2,25,30)(H,26,29) IOOJBEGGDOHLMT-UHFFFAOYSA-N 167442 US9073906, 124 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167442&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70674566 312321288 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311157 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCCN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 InChI=1S/C23H29Cl3N4O4S/c24-16-7-17(25)21(18(26)8-16)30-4-2-1-3-29(35(30,33)34)12-19(31)28-20-14-5-13-6-15(20)11-23(9-13,10-14)22(27)32/h7-8,13-15,20H,1-6,9-12H2,(H2,27,32)(H,28,31) HUZDSKQBMBUYIL-UHFFFAOYSA-N 167440 US9073906, 122 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167440&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70674564 312321286 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311158 CN(CC(=O)NC1C2CC3CC1CC(C3)(C2)C(N)=O)S(=O)(=O)N(C)c1c(Cl)cc(Cl)cc1Cl InChI=1S/C21H27Cl3N4O4S/c1-27(33(31,32)28(2)19-15(23)5-14(22)6-16(19)24)10-17(29)26-18-12-3-11-4-13(18)9-21(7-11,8-12)20(25)30/h5-6,11-13,18H,3-4,7-10H2,1-2H3,(H2,25,30)(H,26,29) ZXKXHXSLZMVQOJ-UHFFFAOYSA-N 167441 US9073906, 123 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167441&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70674565 312321287 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311159 CC1CCN(c2c(Cl)cc(Cl)cc2Cl)S(=O)(=O)N1CC(=O)NC1C2CC3CC1CC(C3)(C2)C(N)=O InChI=1S/C23H29Cl3N4O4S/c1-12-2-3-29(21-17(25)6-16(24)7-18(21)26)35(33,34)30(12)11-19(31)28-20-14-4-13-5-15(20)10-23(8-13,9-14)22(27)32/h6-7,12-15,20H,2-5,8-11H2,1H3,(H2,27,32)(H,28,31) KDBJXWWCAJDIQK-UHFFFAOYSA-N 167443 US9073906, 128 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167443&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70694375 312321289 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311160 CC1CN(CC(=O)NC2C3CC4CC2CC(C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(Cl)cc1Cl InChI=1S/C23H29Cl3N4O4S/c1-12-9-29(35(33,34)30(10-12)21-17(25)4-16(24)5-18(21)26)11-19(31)28-20-14-2-13-3-15(20)8-23(6-13,7-14)22(27)32/h4-5,12-15,20H,2-3,6-11H2,1H3,(H2,27,32)(H,28,31) WMNWSFCMPBLVPL-UHFFFAOYSA-N 167444 US9073906, 156 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167444&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70675147 312321290 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311161 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CC(=C)CN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 InChI=1S/C23H27Cl3N4O4S/c1-12-9-29(35(33,34)30(10-12)21-17(25)4-16(24)5-18(21)26)11-19(31)28-20-14-2-13-3-15(20)8-23(6-13,7-14)22(27)32/h4-5,13-15,20H,1-3,6-11H2,(H2,27,32)(H,28,31) WHPQORAGNCWNKF-UHFFFAOYSA-N 167446 US9073906, 175 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167446&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70688125 312321292 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311162 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CC4(CC4)CN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 InChI=1S/C24H29Cl3N4O4S/c25-16-5-17(26)21(18(27)6-16)31-12-23(1-2-23)11-30(36(31,34)35)10-19(32)29-20-14-3-13-4-15(20)9-24(7-13,8-14)22(28)33/h5-6,13-15,20H,1-4,7-12H2,(H2,28,33)(H,29,32) XRPJXKCLRDTXEV-UHFFFAOYSA-N 167447 US9073906, 176 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167447&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70683860 312321293 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311163 CC1(C)CN(CC(=O)NC2C3CC4CC2CC(C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(Cl)cc1Cl InChI=1S/C24H31Cl3N4O4S/c1-23(2)11-30(36(34,35)31(12-23)21-17(26)5-16(25)6-18(21)27)10-19(32)29-20-14-3-13-4-15(20)9-24(7-13,8-14)22(28)33/h5-6,13-15,20H,3-4,7-12H2,1-2H3,(H2,28,33)(H,29,32) OFKAREBCSRAMPJ-UHFFFAOYSA-N 167448 US9073906, 177 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167448&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70683861 312321294 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311164 CC1CN(CC(=O)NC2C3CC4CC2C[C@@](C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(cc1Cl)C(F)(F)F InChI=1S/C24H29Cl2F3N4O4S/c1-12-9-32(38(36,37)33(10-12)21-17(25)4-16(5-18(21)26)24(27,28)29)11-19(34)31-20-14-2-13-3-15(20)8-23(6-13,7-14)22(30)35/h4-5,12-15,20H,2-3,6-11H2,1H3,(H2,30,35)(H,31,34)/t12?,13?,14?,15?,20?,23- DYPNORVQVVTGPG-RXTOPFGNSA-N 167449 US9073906, 183 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167449&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73504915 312321295 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311165 C[C@H]1CN(CC(=O)NC2C3CC4CC2CC(C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(cc1Cl)C(F)(F)F InChI=1S/C24H29Cl2F3N4O4S/c1-12-9-32(38(36,37)33(10-12)21-17(25)4-16(5-18(21)26)24(27,28)29)11-19(34)31-20-14-2-13-3-15(20)8-23(6-13,7-14)22(30)35/h4-5,12-15,20H,2-3,6-11H2,1H3,(H2,30,35)(H,31,34)/t12-,13?,14?,15?,20?,23?/m0/s1 DYPNORVQVVTGPG-QRVGYDDWSA-N 167450 US9073906, 195 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167450&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 89926841 312321296 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311166 C[C@@H]1CN(CC(=O)NC2C3CC4CC2CC(C4)(C3)C(N)=O)S(=O)(=O)N(C1)c1c(Cl)cc(cc1Cl)C(F)(F)F InChI=1S/C24H29Cl2F3N4O4S/c1-12-9-32(38(36,37)33(10-12)21-17(25)4-16(5-18(21)26)24(27,28)29)11-19(34)31-20-14-2-13-3-15(20)8-23(6-13,7-14)22(30)35/h4-5,12-15,20H,2-3,6-11H2,1H3,(H2,30,35)(H,31,34)/t12-,13?,14?,15?,20?,23?/m1/s1 DYPNORVQVVTGPG-YIKKETLJSA-N 167451 US9073906, 196 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167451&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 89926975 312321297 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 311167 NC(=O)C12CC3CC(C1)C(NC(=O)CN1CC(F)(F)CN(c4c(Cl)cc(Cl)cc4Cl)S1(=O)=O)C(C3)C2 InChI=1S/C22H25Cl3F2N4O4S/c23-14-3-15(24)19(16(25)4-14)31-10-22(26,27)9-30(36(31,34)35)8-17(32)29-18-12-1-11-2-13(18)7-21(5-11,6-12)20(28)33/h3-4,11-13,18H,1-2,5-10H2,(H2,28,33)(H,29,32) VUHJWVSJIWIZGH-UHFFFAOYSA-N 167445 US9073906, 172 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent 10.7270/Q2RV0MFB aid1801399 US9073906 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Korea Research Institute of Chemical Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=167445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=167445&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 86708935 312321291 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50099741 CN1CCN(CC1)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1 InChI=1S/C17H21ClN4O3S2/c1-12-14(18)4-3-5-15(12)27(24,25)20-17-19-13(11-26-17)10-16(23)22-8-6-21(2)7-9-22/h3-5,11H,6-10H2,1-2H3,(H,19,20) YDPRNGAPPNPYQQ-UHFFFAOYSA-N 50117900 3-Chloro-2-methyl-N-{4-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzenesulfonamide; hydrochloride (BVT.2733)::CHEMBL463978::CHEMBL553071 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm4014746 10.7270/Q280546B 24294985 Scott, JS; Goldberg, FW; Turnbull, AV AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50117900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50117900&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 6918651 104011311 CHEMBL553071CHEMBL463978 ZINC27210631 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50099742 CCN(CC)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1 InChI=1S/C16H20ClN3O3S2/c1-4-20(5-2)15(21)9-12-10-24-16(18-12)19-25(22,23)14-8-6-7-13(17)11(14)3/h6-8,10H,4-5,9H2,1-3H3,(H,18,19) PNFMZAHWOASGJC-UHFFFAOYSA-N 50117901 2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide::2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thiazol-4-yl]-N,N-diethyl-acetamide::2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thiazol-4-yl]-N,N-diethyl-acetamide (BVT.14225)::BVT-14225::CHEMBL341324 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm4014746 10.7270/Q280546B 24294985 Scott, JS; Goldberg, FW; Turnbull, AV AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50117901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50117901&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 6918663 104011312 CHEMBL341324 ZINC00595364 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50099743 C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCn12 InChI=1S/C17H25N3/c1-2-4-15-18-19-16(20(15)5-3-1)17-9-12-6-13(10-17)8-14(7-12)11-17/h12-14H,1-11H2 VFTQRHWULYJKCI-UHFFFAOYSA-N 50239401 3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine::CHEMBL256777::MERCK-544 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >3000 ChEMBL 10.1021/jm4014746 10.7270/Q280546B 24294985 Scott, JS; Goldberg, FW; Turnbull, AV AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3630776 104056507 CHEMBL256777 ZINC05494877 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50137624 CC1(C)[C@@H](N)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O InChI=1S/C30H47NO3/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)31)20(32)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23H,8-15,17,31H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 PDFJNRYEGQKVDI-YKLVYJNSSA-N 50188387 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-amino-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::CHEMBL425772 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 6040 ChEMBL 10.1021/jm0600794 10.7270/Q2PN958F 16759088 Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A University of Innsbruck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188387&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11853305 104072180 CHEMBL425772 ZINC13370827 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50137637 COC(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](Oc6ccccc6C(O)=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 InChI=1S/C38H52O6/c1-33(2)28-13-16-38(7)30(36(28,5)15-14-29(33)44-27-12-10-9-11-23(27)31(40)41)26(39)21-24-25-22-35(4,32(42)43-8)18-17-34(25,3)19-20-37(24,38)6/h9-12,21,25,28-30H,13-20,22H2,1-8H3,(H,40,41)/t25-,28-,29-,30+,34+,35-,36-,37+,38+/m0/s1 LNZWDWPFTHLSHQ-WFLSRWDRSA-N 50188386 2-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-(methoxycarbonyl)-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yloxy)benzoic acid::CHEMBL382614 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 48000 ChEMBL 10.1021/jm0600794 10.7270/Q2PN958F 16759088 Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A University of Innsbruck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188386&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11478969 104072179 CHEMBL382614 ZINC36286378 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50137641 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C32H48O5/c1-19(33)37-24-10-11-30(6)23(27(24,2)3)9-12-32(8)25(30)22(34)17-20-21-18-29(5,26(35)36)14-13-28(21,4)15-16-31(20,32)7/h17,21,23-25H,9-16,18H2,1-8H3,(H,35,36)/t21-,23-,24-,25+,28+,29-,30-,31+,32+/m0/s1 FTQDJVZNPJRVPG-XWEVEMRCSA-N 50188385 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::(3beta,18beta,20beta)-3-(Acetyloxy)-11-oxo-olean-12-en-29-oic acid::CHEMBL207413 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 6430 ChEMBL 10.1021/jm0600794 10.7270/Q2PN958F 16759088 Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A University of Innsbruck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188385&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 94320 104072178 CHEMBL207413 C17734 ZINC34169081 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50284293 Clc1ccc(cc1)C1(CC1)c1nnc2c(cccn12)C1CC1 InChI=1S/C18H16ClN3/c19-14-7-5-13(6-8-14)18(9-10-18)17-21-20-16-15(12-3-4-12)2-1-11-22(16)17/h1-2,5-8,11-12H,3-4,9-10H2 DSIKPABWAOKGSR-UHFFFAOYSA-N 50054691 CHEMBL3318978 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/ml500144h 10.7270/Q2N0186W 25050169 Li, J; Kennedy, LJ; Wang, H; Li, JJ; Walker, SJ; Hong, Z; O'Connor, SP; Nayeem, A; Camac, DM; Morin, PE; Sheriff, S; Wang, M; Harper, T; Golla, R; Seethala, R; Harrity, T; Ponticiello, RP; Morgan, NN; Taylor, JR; Zebo, R; Gordon, DA; Robl, JA Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054691&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 1EQ 118709259 103951276 CHEMBL3318978 ZINC13760418 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50303678 C[C@@H]1CN(CCN1c1cccc(n1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1ccc(cc1)S(C)(=O)=O InChI=1S/C28H36N4O4S/c1-18-17-31(22-6-8-23(9-7-22)37(2,35)36)10-11-32(18)25-5-3-4-24(29-25)27(33)30-26-20-12-19-13-21(26)16-28(34,14-19)15-20/h3-9,18-21,26,34H,10-17H2,1-2H3,(H,30,33)/t18-,19?,20?,21?,26-,28-/m1/s1 AKFNADJKXYYHSU-ORJPJIMZSA-N 50066892 CHEMBL3401681 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2015.03.003 10.7270/Q2X3504Q 25800116 Ryu, JH; Kim, S; Lee, JA; Han, HY; Son, HJ; Lee, HJ; Kim, YH; Kim, JS; Park, HG Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066892&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 67468231 103961428 CHEMBL3401681 ZINC13555843 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50303683 C[C@@H]1CN(CCN1c1cccc(n1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2)c1ccc(cc1)C(C)(C)O InChI=1S/C30H40N4O3/c1-19-18-33(24-9-7-23(8-10-24)29(2,3)36)11-12-34(19)26-6-4-5-25(31-26)28(35)32-27-21-13-20-14-22(27)17-30(37,15-20)16-21/h4-10,19-22,27,36-37H,11-18H2,1-3H3,(H,32,35)/t19-,20?,21?,22?,27-,30-/m1/s1 MFRDWNHZMWWHID-HXJLLXCMSA-N 50066896 CHEMBL3401685 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2015.03.003 10.7270/Q2X3504Q 25800116 Ryu, JH; Kim, S; Lee, JA; Han, HY; Son, HJ; Lee, HJ; Kim, YH; Kim, JS; Park, HG Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066896&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 67464068 103961432 CHEMBL3401685 ZINC27210794 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50303709 CS(=O)(=O)c1ccc(cc1)N1CCN(CC1)c1cccc(n1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C27H34N4O4S/c1-36(34,35)22-7-5-21(6-8-22)30-9-11-31(12-10-30)24-4-2-3-23(28-24)26(32)29-25-19-13-18-14-20(25)17-27(33,15-18)16-19/h2-8,18-20,25,33H,9-17H2,1H3,(H,29,32)/t18?,19?,20?,25-,27- RVCXZLTZJNETRZ-CUFZNKPVSA-N 50066871 CHEMBL3401671 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2015.03.003 10.7270/Q2X3504Q 25800116 Ryu, JH; Kim, S; Lee, JA; Han, HY; Son, HJ; Lee, HJ; Kim, YH; Kim, JS; Park, HG Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066871&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54590876 103961407 CHEMBL3401671 ZINC13555814 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50309300 FC(F)(F)c1ccc(cc1)-c1coc(NS(=O)(=O)c2ccccc2)n1 InChI=1S/C16H11F3N2O3S/c17-16(18,19)12-8-6-11(7-9-12)14-10-24-15(20-14)21-25(22,23)13-4-2-1-3-5-13/h1-10H,(H,20,21) WGTONQCOIHXYJF-UHFFFAOYSA-N 50167716 CHEMBL383820::N-(4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)benzenesulfonamide::N-[4-(4-Trifluoromethyl-phenyl)-oxazol-2-yl]-benzenesulfonamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmcl.2005.03.093 10.7270/Q2TB16DR 15911270 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167716&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11257147 104052932 CHEMBL383820 ZINC28524438 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50309302 FC(F)(F)c1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1 InChI=1S/C15H11F3O3S/c16-15(17,18)12-8-6-11(7-9-12)14(19)10-22(20,21)13-4-2-1-3-5-13/h1-9H,10H2 PDXUGNITDTZZFN-UHFFFAOYSA-N 50167718 2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethanone::2-Benzenesulfonyl-1-(4-trifluoromethyl-phenyl)-ethanone::CHEMBL383146 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmcl.2005.03.093 10.7270/Q2TB16DR 15911270 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167718&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11232699 104052934 CHEMBL383146 ZINC13981551 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50309308 Cc1c(Cl)cccc1S(=O)(=O)Nc1nc(co1)-c1ccc(cc1)C#N InChI=1S/C17H12ClN3O3S/c1-11-14(18)3-2-4-16(11)25(22,23)21-17-20-15(10-24-17)13-7-5-12(9-19)6-8-13/h2-8,10H,1H3,(H,20,21) RZQWIWDBGOCDMD-UHFFFAOYSA-N 50167723 3-Chloro-N-[4-(4-cyano-phenyl)-oxazol-2-yl]-2-methyl-benzenesulfonamide::3-chloro-N-(4-(4-cyanophenyl)oxazol-2-yl)-2-methylbenzenesulfonamide::CHEMBL196782 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmcl.2005.03.093 10.7270/Q2TB16DR 15911270 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167723&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44402550 104052939 CHEMBL196782 ZINC28525284 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50309309 O=S(=O)(Nc1nc(co1)-c1ccc(cc1)-c1ccccc1)c1ccccc1 InChI=1S/C21H16N2O3S/c24-27(25,19-9-5-2-6-10-19)23-21-22-20(15-26-21)18-13-11-17(12-14-18)16-7-3-1-4-8-16/h1-15H,(H,22,23) VGMAXBHEEZUHPB-UHFFFAOYSA-N 50167720 CHEMBL197151::N-(4-Biphenyl-4-yl-oxazol-2-yl)-benzenesulfonamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmcl.2005.03.093 10.7270/Q2TB16DR 15911270 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167720&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11280328 104052936 CHEMBL197151 ZINC13981549 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50309310 O=S(=O)(Nc1nc(co1)-c1ccccc1)c1ccccc1 InChI=1S/C15H12N2O3S/c18-21(19,13-9-5-2-6-10-13)17-15-16-14(11-20-15)12-7-3-1-4-8-12/h1-11H,(H,16,17) IOHIFKKCDMQXEE-UHFFFAOYSA-N 50167721 CHEMBL425022::N-(4-Phenyl-oxazol-2-yl)-benzenesulfonamide::N-(4-phenyloxazol-2-yl)benzenesulfonamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmcl.2005.03.093 10.7270/Q2TB16DR 15911270 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167721&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44402393 104052937 CHEMBL425022 ZINC28525285 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50309315 CN(C(C)=O)c1ccc(cc1)S(=O)(=O)Nc1nc(C)c(C)o1 InChI=1S/C14H17N3O4S/c1-9-10(2)21-14(15-9)16-22(19,20)13-7-5-12(6-8-13)17(4)11(3)18/h5-8H,1-4H3,(H,15,16) MNVKGQJDZLWNGW-UHFFFAOYSA-N 50167724 CHEMBL372623::N-[4-(4,5-Dimethyl-oxazol-2-ylsulfamoyl)-phenyl]-N-methyl-acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmcl.2005.03.093 10.7270/Q2TB16DR 15911270 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167724&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44402662 104052940 CHEMBL372623 ZINC28525594 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50309316 CCN(CC)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1 InChI=1S/C16H20ClN3O3S2/c1-4-20(5-2)15(21)9-12-10-24-16(18-12)19-25(22,23)14-8-6-7-13(17)11(14)3/h6-8,10H,4-5,9H2,1-3H3,(H,18,19) PNFMZAHWOASGJC-UHFFFAOYSA-N 50117901 2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide::2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thiazol-4-yl]-N,N-diethyl-acetamide::2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thiazol-4-yl]-N,N-diethyl-acetamide (BVT.14225)::BVT-14225::CHEMBL341324 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmcl.2005.03.093 10.7270/Q2TB16DR 15911270 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50117901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50117901&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 6918663 104011312 CHEMBL341324 ZINC00595364 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50309317 Cc1c(Cl)cccc1S(=O)(=O)Nc1nc(co1)-c1ccccc1 InChI=1S/C16H13ClN2O3S/c1-11-13(17)8-5-9-15(11)23(20,21)19-16-18-14(10-22-16)12-6-3-2-4-7-12/h2-10H,1H3,(H,18,19) JTLATYLNDGVHFD-UHFFFAOYSA-N 50167717 3-Chloro-2-methyl-N-(4-phenyl-oxazol-2-yl)-benzenesulfonamide::CHEMBL371074 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmcl.2005.03.093 10.7270/Q2TB16DR 15911270 Xiang, J; Ipek, M; Suri, V; Massefski, W; Pan, N; Ge, Y; Tam, M; Xing, Y; Tobin, JF; Xu, X; Tam, S Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167717&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44402534 104052933 CHEMBL371074 ZINC28525629 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50322109 Cc1noc(n1)C12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C19H27N5O/c1-14-20-17(25-23-14)19-10-7-18(8-11-19,9-12-19)16-22-21-15-6-4-2-3-5-13-24(15)16/h2-13H2,1H3 KICDTKNTZWAWJS-UHFFFAOYSA-N 50174280 3-(4-(3-methyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL200351 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2005.08.052 10.7270/Q2QC031M 16185866 Gu, X; Dragovic, J; Koo, GC; Koprak, SL; LeGrand, C; Mundt, SS; Shah, K; Springer, MS; Tan, EY; Thieringer, R; Hermanowski-Vosatka, A; Zokian, HJ; Balkovec, JM; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174280&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11739354 104060098 CHEMBL200351 ZINC28563041 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50322143 CCCCCC12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C21H35N3/c1-2-3-7-10-20-11-14-21(15-12-20,16-13-20)19-23-22-18-9-6-4-5-8-17-24(18)19/h2-17H2,1H3 HISKJZZJMYSEGO-UHFFFAOYSA-N 50174285 3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL200513 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 183 ChEMBL 10.1016/j.bmcl.2005.08.052 10.7270/Q2QC031M 16185866 Gu, X; Dragovic, J; Koo, GC; Koprak, SL; LeGrand, C; Mundt, SS; Shah, K; Springer, MS; Tan, EY; Thieringer, R; Hermanowski-Vosatka, A; Zokian, HJ; Balkovec, JM; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174285&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11771845 104060103 CHEMBL200513 ZINC06717978 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50322149 Clc1ccc(cc1)-c1noc(n1)C12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C24H28ClN5O/c25-18-8-6-17(7-9-18)20-26-22(31-29-20)24-13-10-23(11-14-24,12-15-24)21-28-27-19-5-3-1-2-4-16-30(19)21/h6-9H,1-5,10-16H2 YWNBNSZDPNFYMX-UHFFFAOYSA-N 50174279 3-(4-(3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL372768 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 228 ChEMBL 10.1016/j.bmcl.2005.08.052 10.7270/Q2QC031M 16185866 Gu, X; Dragovic, J; Koo, GC; Koprak, SL; LeGrand, C; Mundt, SS; Shah, K; Springer, MS; Tan, EY; Thieringer, R; Hermanowski-Vosatka, A; Zokian, HJ; Balkovec, JM; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174279&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11259177 104060097 CHEMBL372768 ZINC28529086 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50322154 COC(=O)C12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C18H27N3O2/c1-23-16(22)18-10-7-17(8-11-18,9-12-18)15-20-19-14-6-4-2-3-5-13-21(14)15/h2-13H2,1H3 IZAFVIFMEVBOTI-UHFFFAOYSA-N 50174294 CHEMBL200876::methyl 4-(5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)bicyclo[2.2.2]octane-1-carboxylate 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2005.08.052 10.7270/Q2QC031M 16185866 Gu, X; Dragovic, J; Koo, GC; Koprak, SL; LeGrand, C; Mundt, SS; Shah, K; Springer, MS; Tan, EY; Thieringer, R; Hermanowski-Vosatka, A; Zokian, HJ; Balkovec, JM; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174294&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11278558 104060112 CHEMBL200876 ZINC28562849 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50327765 CC(=O)O[C@@H]1C[C@@H]2[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]2(C)[C@@]2(C)[C@H]1C=CC2=O InChI=1S/C24H36O4/c1-14(25)28-16-13-18-22(4)11-10-19(26)21(2,3)17(22)9-12-23(18,5)24(6)15(16)7-8-20(24)27/h7-8,15-19,26H,9-13H2,1-6H3/t15-,16+,17-,18+,19-,22-,23+,24-/m0/s1 PVKPXFJHPNYMGT-NRAQGITCSA-N 50080410 CHEMBL3422416 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 11300 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080410&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911915 313074177 CHEMBL3422416 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50327766 C[C@]12[C@@H](C=CC1=O)[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C22H34O3/c1-19(2)15-8-11-21(4)16(20(15,3)10-9-17(19)24)12-14(23)13-6-7-18(25)22(13,21)5/h6-7,13-17,23-24H,8-12H2,1-5H3/t13-,14+,15-,16+,17-,20-,21+,22-/m0/s1 UUHVPIJALZYQLA-LNRMMRAHSA-N 50080411 CHEMBL3422415 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 283600 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080411&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911914 313074178 CHEMBL3422415 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50327767 CC(=O)O[C@@H]1C[C@@H]2[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]2(C)[C@@]2(C)[C@H]1[C@H](O)CC2=O InChI=1S/C24H38O5/c1-13(25)29-15-12-17-22(4)9-8-18(27)21(2,3)16(22)7-10-23(17,5)24(6)19(28)11-14(26)20(15)24/h14-18,20,26-27H,7-12H2,1-6H3/t14-,15-,16+,17-,18+,20+,22+,23-,24-/m1/s1 LUZLPULOHLRSON-AXEWUURISA-N 50080412 CHEMBL3422266 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 299600 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080412&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911913 313074179 CHEMBL3422266 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50327768 CO[C@@H]1CC(=O)[C@]2(C)[C@@H]1[C@@H](C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C)OC(C)=O InChI=1S/C25H40O5/c1-14(26)30-16-12-18-23(4)10-9-19(27)22(2,3)17(23)8-11-24(18,5)25(6)20(28)13-15(29-7)21(16)25/h15-19,21,27H,8-13H2,1-7H3/t15-,16-,17+,18-,19+,21+,23+,24-,25-/m1/s1 CTERVLHXMOVKJM-YLXWABNASA-N 50080413 CHEMBL3422265 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 40700 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080413&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911912 313074180 CHEMBL3422265 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50327769 CO[C@@H]1CC(=O)[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C23H38O4/c1-20(2)15-7-10-22(4)16(21(15,3)9-8-17(20)25)11-13(24)19-14(27-6)12-18(26)23(19,22)5/h13-17,19,24-25H,7-12H2,1-6H3/t13-,14-,15+,16-,17+,19-,21+,22-,23-/m1/s1 ZENVSCKOBKOTSJ-RTFSNDOKSA-N 50080424 CHEMBL3422264 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 25500 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080424&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101911911 313074181 CHEMBL3422264 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50327776 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 MPDGHEJMBKOTSU-YKLVYJNSSA-N 50233538 18beta-glycyrrhetic acid::3beta-hydroxy-11-oxoolean-12-en-30-oic acid::CHEMBL230006::US11660306, Example 18beta Glycyrrhetinic acid::glycyrrhetinic acid 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1.2 ChEMBL 10.1021/np500896n 10.7270/Q2930VWF 25590374 Chen, XQ; Shao, LD; Pal, M; Shen, Y; Cheng, X; Xu, G; Peng, LY; Wang, K; Pan, ZH; Li, MM; Leng, Y; He, J; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50233538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50233538&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CBW 10114 104055693 30853 CHEMBL230006 C02283 ZINC19203131 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356199 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C24H34F3N5O2/c1-23(2,22(34)30-20-15-4-3-5-16(20)13-17(12-15)21(28)33)32-10-8-31(9-11-32)19-7-6-18(14-29-19)24(25,26)27/h6-7,14-17,20H,3-5,8-13H2,1-2H3,(H2,28,33)(H,30,34)/t15?,16?,17-,20- SXGLAMMLCWTPKO-MXYWLUFOSA-N 50192672 (3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL219403 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192672&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418445 104075531 CHEMBL219403 ZINC36286151 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356200 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1CC(O)(C2)O3 InChI=1S/C19H24ClNO4/c1-18(2,24-14-5-3-13(20)4-6-14)17(22)21-16-11-7-15-8-12(16)10-19(23,9-11)25-15/h3-6,11-12,15-16,23H,7-10H2,1-2H3,(H,21,22)/t11?,12?,15?,16-,19? CTKDNRAPWIIIPH-XUGVBQLSSA-N 50192673 2-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxa-tricyclo[3.3.1.13,7]dec-6-yl)-2-methyl-propionamide::2-(4-chlorophenoxy)-N-(1-hydroxy-2-oxatricyclo[3.3.1.1~3,7~]dec-6-yl)-2-methylpropanamide::CHEMBL373601 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 70000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192673&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418389 104075532 CHEMBL373601 ZINC36286137 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356209 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(O)=O InChI=1S/C24H33F3N4O3/c1-23(2,22(34)29-20-15-4-3-5-16(20)13-17(12-15)21(32)33)31-10-8-30(9-11-31)19-7-6-18(14-28-19)24(25,26)27/h6-7,14-17,20H,3-5,8-13H2,1-2H3,(H,29,34)(H,32,33)/t15?,16?,17-,20- JBFDKOOTXBMPAU-MXYWLUFOSA-N 50192676 (3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxylic acid::CHEMBL374409 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192676&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418450 104075535 CHEMBL374409 ZINC36286158 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356224 CC(C)(Oc1ccc(Cl)cc1)C(=O)NC12CCC(CC1)(CC2)C(N)=O InChI=1S/C19H25ClN2O3/c1-17(2,25-14-5-3-13(20)4-6-14)16(24)22-19-10-7-18(8-11-19,9-12-19)15(21)23/h3-6H,7-12H2,1-2H3,(H2,21,23)(H,22,24) LJXXAAVCYKDWBK-UHFFFAOYSA-N 50192686 4-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo[2.2.2]octane-1-carboxamide::CHEMBL219606 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192686&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 16049788 104075545 CHEMBL219606 ZINC34947170 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356226 CC(C)(Oc1ccc(cn1)C#N)C(=O)N[C@@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C20H26N4O3/c1-20(2,27-16-7-6-12(10-21)11-23-16)19(26)24-17-13-4-3-5-14(17)9-15(8-13)18(22)25/h6-7,11,13-15,17H,3-5,8-9H2,1-2H3,(H2,22,25)(H,24,26)/t13?,14?,15-,17+ HYHSWNNFVLLHEA-MMKREDLLSA-N 50192684 (3s,9s)-9-(2-(5-cyanopyridin-2-yloxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL219295 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192684&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418375 104075543 CHEMBL219295 ZINC36286169 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356230 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C20H27ClN2O3/c1-20(2,26-16-8-6-15(21)7-9-16)19(25)23-17-12-4-3-5-13(17)11-14(10-12)18(22)24/h6-9,12-14,17H,3-5,10-11H2,1-2H3,(H2,22,24)(H,23,25)/t12?,13?,14-,17- VSBPAZLSKLWBGS-HFVRJFBJSA-N 50192679 (3r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL219448 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192679&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418382 104075538 CHEMBL219448 ZINC29126263 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356239 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C24H34F3N5O2/c1-23(2,22(34)30-20-15-4-3-5-16(20)13-17(12-15)21(28)33)32-10-8-31(9-11-32)19-7-6-18(14-29-19)24(25,26)27/h6-7,14-17,20H,3-5,8-13H2,1-2H3,(H2,28,33)(H,30,34)/t15?,16?,17-,20- SXGLAMMLCWTPKO-MXYWLUFOSA-N 50192672 (3r,9r)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL219403 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192672&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418445 104075531 CHEMBL219403 ZINC36286151 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356244 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CCC1C[C@H](C2)C(O)=O InChI=1S/C23H31F3N4O3/c1-22(2,21(33)28-19-14-3-4-15(19)12-16(11-14)20(31)32)30-9-7-29(8-10-30)18-6-5-17(13-27-18)23(24,25)26/h5-6,13-16,19H,3-4,7-12H2,1-2H3,(H,28,33)(H,31,32)/t14?,15?,16-,19- XJQAEHQNLAKSQM-MUZLMXHHSA-N 50192682 (3r,8r)-8-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.2.1]octane-3-carboxylic acid::CHEMBL216783 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192682&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418441 104075541 CHEMBL216783 ZINC36286384 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356245 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)NC12CCC(CC1)(CC2)C(N)=O InChI=1S/C23H32F3N5O2/c1-20(2,19(33)29-22-8-5-21(6-9-22,7-10-22)18(27)32)31-13-11-30(12-14-31)17-4-3-16(15-28-17)23(24,25)26/h3-4,15H,5-14H2,1-2H3,(H2,27,32)(H,29,33) ZJEWQOHEBJRFFN-UHFFFAOYSA-N 50192674 4-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[2.2.2]octane-1-carboxamide::CHEMBL218247 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 90000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192674&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418456 104075533 CHEMBL218247 ZINC36286166 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356251 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H]1C2CCCC1C[C@H](C2)C(O)=O InChI=1S/C20H26ClNO4/c1-20(2,26-16-8-6-15(21)7-9-16)19(25)22-17-12-4-3-5-13(17)11-14(10-12)18(23)24/h6-9,12-14,17H,3-5,10-11H2,1-2H3,(H,22,25)(H,23,24)/t12?,13?,14-,17+ MGYATIZKIVDSGV-QODXQOHISA-N 50192685 (3s,9s)-9-(2-(4-chlorophenoxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxylic acid::CHEMBL386315 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 16000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192685&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418376 104075544 CHEMBL386315 ZINC36286176 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356259 CC(C)(Oc1ccc(Cl)cc1)C(=O)NC1CCCC(CCC1)C#N InChI=1S/C19H25ClN2O2/c1-19(2,24-17-11-9-15(20)10-12-17)18(23)22-16-7-3-5-14(13-21)6-4-8-16/h9-12,14,16H,3-8H2,1-2H3,(H,22,23) XXQVINRKAJUVSG-UHFFFAOYSA-N 50192671 2-(4-chlorophenoxy)-N-(5-cyanocyclooctyl)-2-methylpropanamide::CHEMBL387010 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192671&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418457 104075530 CHEMBL387010 ZINC36286164 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356262 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2COCC1C[C@H](C2)C(N)=O InChI=1S/C19H25ClN2O4/c1-19(2,26-15-5-3-14(20)4-6-15)18(24)22-16-12-7-11(17(21)23)8-13(16)10-25-9-12/h3-6,11-13,16H,7-10H2,1-2H3,(H2,21,23)(H,22,24)/t11-,12?,13?,16- RHXKGFMFYVEJCA-GKGIWJEVSA-N 50192675 (7r,9r)-9-(2-(4-chlorophenoxy)-2-methylpropanamido)-3-oxa-bicyclo[3.3.1]nonane-7-carboxamide::CHEMBL376272 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192675&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418383 104075534 CHEMBL376272 ZINC36286132 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356263 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@@H]1C2CCCC1C[C@H](C2)C(N)=O InChI=1S/C24H34F3N5O2/c1-23(2,22(34)30-20-15-4-3-5-16(20)13-17(12-15)21(28)33)32-10-8-31(9-11-32)19-7-6-18(14-29-19)24(25,26)27/h6-7,14-17,20H,3-5,8-13H2,1-2H3,(H2,28,33)(H,30,34)/t15?,16?,17-,20+ SXGLAMMLCWTPKO-SUFHFBDXSA-N 50192683 (3s,9s)-9-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL384426 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192683&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418445 104075542 CHEMBL384426 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356215 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)NC1CCCC(CCC1)C#N InChI=1S/C23H32F3N5O/c1-22(2,21(32)29-19-7-3-5-17(15-27)6-4-8-19)31-13-11-30(12-14-31)20-10-9-18(16-28-20)23(24,25)26/h9-10,16-17,19H,3-8,11-14H2,1-2H3,(H,29,32) DJTWBQCPSRQQDF-UHFFFAOYSA-N 50192681 CHEMBL218246::N-(5-cyanocyclooctyl)-2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192681&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418433 104075540 CHEMBL218246 ZINC36286142 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356269 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)NC1CC[C@H]2[C@@H](CC1)[C@@H]2C(N)=O InChI=1S/C23H32F3N5O2/c1-22(2,21(33)29-15-4-6-16-17(7-5-15)19(16)20(27)32)31-11-9-30(10-12-31)18-8-3-14(13-28-18)23(24,25)26/h3,8,13,15-17,19H,4-7,9-12H2,1-2H3,(H2,27,32)(H,29,33)/t15?,16-,17+,19+ OJTRJEAMMHBCDD-VVXSQCBMSA-N 50192677 (1R,7S,8r)-4-(2-methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[5.1.0]octane-8-carboxamide::CHEMBL375743 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2006.07.062 10.7270/Q2XG9QRS 16890427 Yeh, VS; Kurukulasuriya, R; Madar, D; Patel, JR; Fung, S; Monzon, K; Chiou, W; Wang, J; Jacobson, P; Sham, HL; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192677&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418434 104075536 CHEMBL375743 ZINC36286147 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50348707 CC1(C)[C@@H](N)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O InChI=1S/C30H47NO3/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)31)20(32)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23H,8-15,17,31H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 PDFJNRYEGQKVDI-YKLVYJNSSA-N 50188387 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-amino-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::CHEMBL425772 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 60 ChEMBL 10.1021/jm0600794 10.7270/Q2PN958F 16759088 Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A University of Innsbruck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188387&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11853305 104072180 CHEMBL425772 ZINC13370827 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50348709 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C32H48O5/c1-19(33)37-24-10-11-30(6)23(27(24,2)3)9-12-32(8)25(30)22(34)17-20-21-18-29(5,26(35)36)14-13-28(21,4)15-16-31(20,32)7/h17,21,23-25H,9-16,18H2,1-8H3,(H,35,36)/t21-,23-,24-,25+,28+,29-,30-,31+,32+/m0/s1 FTQDJVZNPJRVPG-XWEVEMRCSA-N 50188385 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::(3beta,18beta,20beta)-3-(Acetyloxy)-11-oxo-olean-12-en-29-oic acid::CHEMBL207413 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 201 ChEMBL 10.1021/jm0600794 10.7270/Q2PN958F 16759088 Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A University of Innsbruck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188385&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 94320 104072178 CHEMBL207413 C17734 ZINC34169081 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50348714 CC(CCC(O)=O)C1CC[C@@]2(C)C3=C(C(=O)C[C@]12C)[C@@]1(C)CCC(OC(C)=O)C(C)(C)[C@@H]1CC3=O InChI=1S/C29H42O6/c1-16(8-9-23(33)34)18-10-13-28(6)25-19(31)14-21-26(3,4)22(35-17(2)30)11-12-27(21,5)24(25)20(32)15-29(18,28)7/h16,18,21-22H,8-15H2,1-7H3,(H,33,34)/t16?,18?,21-,22?,27-,28-,29+/m0/s1 JIKRXLHICUVFAL-PCIHFJPFSA-N 50188390 4-((5R,10S,13R,14R)-3-acetoxy-4,4,10,13,14-pentamethyl-7,11-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid::CHEMBL211039 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3950 ChEMBL 10.1021/jm0600794 10.7270/Q2PN958F 16759088 Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A University of Innsbruck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188390&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11375180 104072183 CHEMBL211039 ZINC33888636 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50348718 COC(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](Oc6ccccc6C(O)=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 InChI=1S/C38H52O6/c1-33(2)28-13-16-38(7)30(36(28,5)15-14-29(33)44-27-12-10-9-11-23(27)31(40)41)26(39)21-24-25-22-35(4,32(42)43-8)18-17-34(25,3)19-20-37(24,38)6/h9-12,21,25,28-30H,13-20,22H2,1-8H3,(H,40,41)/t25-,28-,29-,30+,34+,35-,36-,37+,38+/m0/s1 LNZWDWPFTHLSHQ-WFLSRWDRSA-N 50188386 2-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-(methoxycarbonyl)-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yloxy)benzoic acid::CHEMBL382614 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 280 ChEMBL 10.1021/jm0600794 10.7270/Q2PN958F 16759088 Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A University of Innsbruck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188386&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11478969 104072179 CHEMBL382614 ZINC36286378 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50348724 COCCC1C(C(C(=O)c2ccc(OC)c(C)c2)C(=O)C1=O)c1ccc(Cl)cc1Cl InChI=1S/C23H22Cl2O5/c1-12-10-13(4-7-18(12)30-3)21(26)20-19(15-6-5-14(24)11-17(15)25)16(8-9-29-2)22(27)23(20)28/h4-7,10-11,16,19-20H,8-9H2,1-3H3 BPOHPEHPEDXGDF-UHFFFAOYSA-N 50188391 4-(2,4-dichlorophenyl)-2-hydroxy-3-(4-methoxy-3-methylbenzoyl)-5-(2-methoxyethyl)cyclopent-2-enone::CHEMBL206908 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1021/jm0600794 10.7270/Q2PN958F 16759088 Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A University of Innsbruck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188391&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11408286 104072184 CHEMBL206908 ZINC49937646 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50348735 C[C@H]1C[C@@]2(C)CC[C@@](C)(C[C@@]2(C)C2=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]12C)C(=O)N[C@H](Cc1ccccc1)C(O)=O InChI=1S/C41H59NO5/c1-25-23-37(5)20-19-36(4,34(47)42-27(33(45)46)21-26-13-11-10-12-14-26)24-40(37,8)30-22-28(43)32-38(6)17-16-31(44)35(2,3)29(38)15-18-39(32,7)41(25,30)9/h10-14,22,25,27,29,31-32,44H,15-21,23-24H2,1-9H3,(H,42,47)(H,45,46)/t25-,27+,29-,31-,32+,36-,37+,38-,39+,40-,41+/m0/s1 JUNGTNHTGUINCM-PJGSTNTHSA-N 50188388 (R)-2-((2S,4aR,6S,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6,6a,6b,9,9,12a,14b-nonamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamido)-3-phenylpropanoic acid::CHEMBL380677 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2350 ChEMBL 10.1021/jm0600794 10.7270/Q2PN958F 16759088 Schuster, D; Maurer, EM; Laggner, C; Nashev, LG; Wilckens, T; Langer, T; Odermatt, A University of Innsbruck http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188388&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11319723 104072181 CHEMBL380677 ZINC38407011 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356356 CC(C)(Oc1ccc(cn1)C#N)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C22H28N4O3/c1-21(2,29-18-4-3-13(11-23)12-25-18)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-17(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1 YMCQQNULXBTOAK-ADYSRPFESA-N 50192785 CHEMBL385176::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-(5-cyano-pyridin-2-yloxy)-2-methyl-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192785&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418391 104075586 CHEMBL385176 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356359 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(=O)o[nH]1 InChI=1S/C22H26ClN3O4/c1-21(2,29-16-5-3-15(23)4-6-16)19(27)24-17-13-7-12-8-14(17)11-22(9-12,10-13)18-25-20(28)30-26-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,24,27)(H,25,26,28)/t12-,13-,14?,17+,22+/m0/s1 BQNOGCJLFJZJQU-FWQQIOJYSA-N 50192788 2-(4-chloro-phenoxy)-2-methyl-N-[(1R,2S,5S,7S)-5-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-adamantan-2-yl]-propionamide::CHEMBL436335 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 35000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192788&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418377 104075589 CHEMBL436335 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356361 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)C(=N)NO InChI=1S/C21H28ClN3O3/c1-20(2,28-16-5-3-15(22)4-6-16)19(26)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)25-27/h3-6,12-14,17,27H,7-11H2,1-2H3,(H2,23,25)(H,24,26)/t12-,13-,14?,17+,21+/m0/s1 QGTLXYMZZZDJFY-SOHFMQRKSA-N 50192790 2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(N-hydroxycarbamimidoyl)-adamantan-2-yl]-2-methyl-propionamide::CHEMBL375744 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192790&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418459 104075591 CHEMBL375744 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356366 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CCC(O)=O)(C3)C2 InChI=1S/C23H30ClNO4/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)25-20-15-9-14-10-16(20)13-23(11-14,12-15)8-7-19(26)27/h3-6,14-16,20H,7-13H2,1-2H3,(H,25,28)(H,26,27)/t14-,15-,16?,20+,23-/m0/s1 HHSFEYNQHTXPDX-AHTWWQKHSA-N 50192793 3-{(1R,4S,5R,7S)-4-[2-(4-chloro-phenoxy)-2-methyl-propionylamino]-adamantan-1-yl}-propionic acid::CHEMBL219028 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192793&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418385 104075594 CHEMBL219028 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356382 CN1CCN(CC1)c1ccc(OC(C)(C)C(=O)N[C@H]2C3C[C@@H]4C[C@H]2C[C@](CC(N)=O)(C4)C3)nc1 InChI=1S/C26H39N5O3/c1-25(2,34-22-5-4-20(16-28-22)31-8-6-30(3)7-9-31)24(33)29-23-18-10-17-11-19(23)14-26(12-17,13-18)15-21(27)32/h4-5,16-19,23H,6-15H2,1-3H3,(H2,27,32)(H,29,33)/t17-,18-,19?,23+,26+/m0/s1 MVRFQLOMWXUUJU-OECJZQBZSA-N 50192794 CHEMBL216977::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-2-[5-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192794&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418396 104075595 CHEMBL216977 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360513 OC(=O)[C@@]12C[C@H]3CC(C1)[C@H](NC(=O)C1(CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C25H31F3N4O3/c26-25(27,28)18-1-2-19(29-14-18)31-5-7-32(8-6-31)24(3-4-24)21(33)30-20-16-9-15-10-17(20)13-23(11-15,12-16)22(34)35/h1-2,14-17,20H,3-13H2,(H,30,33)(H,34,35)/t15-,16?,17?,20-,23- DVRJUYYCTLYDFA-LYGRSXDVSA-N 50195294 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopropanecarbonyl}-amino)-adamantane-1-carboxylic acid::CHEMBL220883 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195294&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11627334 104077363 CHEMBL220883 ZINC28604536 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360519 OC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C1(CCCC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C27H35F3N4O3/c28-27(29,30)20-3-4-21(31-16-20)33-7-9-34(10-8-33)26(5-1-2-6-26)23(35)32-22-18-11-17-12-19(22)15-25(13-17,14-18)24(36)37/h3-4,16-19,22H,1-2,5-15H2,(H,32,35)(H,36,37)/t17?,18?,19?,22-,25- SCKUCAYPELQYOB-TZKYZTEESA-N 50195295 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopentanecarbonyl}-amino)-adamantane-1-carboxylic acid::CHEMBL222365 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 15000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195295&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420294 104077364 CHEMBL222365 ZINC36286330 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360526 O[C@@]12C[C@H]3CC(C1)[C@H](NC(=O)C1(CC1)N1CCCCC1)C(C3)C2 InChI=1S/C19H30N2O2/c22-17(19(4-5-19)21-6-2-1-3-7-21)20-16-14-8-13-9-15(16)12-18(23,10-13)11-14/h13-16,23H,1-12H2,(H,20,22)/t13-,14?,15?,16-,18- CEZQNMXBDYZVET-NIYRFRDPSA-N 50195289 1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hydroxy-adamantan-2-yl)-amide::CHEMBL220102 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 8300 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195289&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11666874 104077358 CHEMBL220102 ZINC36286294 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360533 OC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C1CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C26H33F3N4O3/c27-26(28,29)19-3-4-20(30-14-19)32-5-7-33(8-6-32)22(16-1-2-16)23(34)31-21-17-9-15-10-18(21)13-25(11-15,12-17)24(35)36/h3-4,14-18,21-22H,1-2,5-13H2,(H,31,34)(H,35,36)/t15?,17?,18?,21-,22?,25- KRSITBCUJXKYET-NNJMJYJPSA-N 50195288 4-{2-cyclopropyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetylamino}-adamantane-1-carboxylic acid::CHEMBL219712 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 24000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195288&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11533520 104077357 CHEMBL219712 ZINC36286321 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360546 OC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C1(CCC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C26H33F3N4O3/c27-26(28,29)19-2-3-20(30-15-19)32-6-8-33(9-7-32)25(4-1-5-25)22(34)31-21-17-10-16-11-18(21)14-24(12-16,13-17)23(35)36/h2-3,15-18,21H,1,4-14H2,(H,31,34)(H,35,36)/t16?,17?,18?,21-,24- BCQSMWWPXGIWEA-DRQKDHDASA-N 50195300 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclobutanecarbonyl}-amino)-adamantane-1-carboxylic acid::CHEMBL223138 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 27000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195300&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11699075 104077369 CHEMBL223138 ZINC36286324 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360547 CCC(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(O)=O InChI=1S/C25H33F3N4O3/c1-2-19(31-5-7-32(8-6-31)20-4-3-18(14-29-20)25(26,27)28)22(33)30-21-16-9-15-10-17(21)13-24(11-15,12-16)23(34)35/h3-4,14-17,19,21H,2,5-13H2,1H3,(H,30,33)(H,34,35)/t15?,16?,17?,19?,21-,24- VUJKPYBHOITRIE-HSUQSKAJSA-N 50195293 4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butyrylamino}-adamantane-1-carboxylic acid::CHEMBL220153 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 65000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195293&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420285 104077362 CHEMBL220153 ZINC36286312 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360555 CCC(N1CCCC(F)(F)C1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O InChI=1S/C20H31F2N3O2/c1-2-15(25-5-3-4-20(21,22)11-25)17(26)24-16-13-6-12-7-14(16)10-19(8-12,9-13)18(23)27/h12-16H,2-11H2,1H3,(H2,23,27)(H,24,26)/t12?,13?,14?,15?,16-,19- JPMYVYXSNDIXGT-IWGYBJIZSA-N 50195298 4-[2-(3,3-difluoro-piperidin-1-yl)-butyrylamino]-adamantane-1-carboxylic acid amide::CHEMBL222319 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195298&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420253 104077367 CHEMBL222319 ZINC36286353 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360557 CCC(N1CCCC(F)(F)C1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(O)=O InChI=1S/C20H30F2N2O3/c1-2-15(24-5-3-4-20(21,22)11-24)17(25)23-16-13-6-12-7-14(16)10-19(8-12,9-13)18(26)27/h12-16H,2-11H2,1H3,(H,23,25)(H,26,27)/t12?,13?,14?,15?,16-,19- BZGXRUGRHXHQKS-IWGYBJIZSA-N 50195303 4-[2-(3,3-difluoro-piperidin-1-yl)-butyrylamino]-adamantane-1-carboxylic acid::CHEMBL223083 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195303&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420249 104077372 CHEMBL223083 ZINC36286346 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360558 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2C[C@H]3CC1C[C@](C3)(C2)C(N)=O InChI=1S/C25H34F3N5O2/c1-23(2,33-7-5-32(6-8-33)19-4-3-18(14-30-19)25(26,27)28)22(35)31-20-16-9-15-10-17(20)13-24(11-15,12-16)21(29)34/h3-4,14-17,20H,5-13H2,1-2H3,(H2,29,34)(H,31,35)/t15-,16?,17?,20-,24- CLHMYBJIOZXCEX-HGYLWUCXSA-N 50195291 4-{2-methyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionylamino}-adamantane-1-carboxylic acid amide::CHEMBL222670 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195291&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11670435 104077360 CHEMBL222670 7357 ZINC34643824 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360562 NC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C1(CCC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C26H34F3N5O2/c27-26(28,29)19-2-3-20(31-15-19)33-6-8-34(9-7-33)25(4-1-5-25)23(36)32-21-17-10-16-11-18(21)14-24(12-16,13-17)22(30)35/h2-3,15-18,21H,1,4-14H2,(H2,30,35)(H,32,36)/t16?,17?,18?,21-,24- YBLQVVARSOXHTM-DRQKDHDASA-N 50195299 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclobutanecarbonyl}-amino)-adamantane-1-carboxylic acid amide::CHEMBL222511 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 34000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195299&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11555218 104077368 CHEMBL222511 ZINC34663384 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360563 CCC(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O InChI=1S/C25H34F3N5O2/c1-2-19(32-5-7-33(8-6-32)20-4-3-18(14-30-20)25(26,27)28)22(34)31-21-16-9-15-10-17(21)13-24(11-15,12-16)23(29)35/h3-4,14-17,19,21H,2,5-13H2,1H3,(H2,29,35)(H,31,34)/t15?,16?,17?,19?,21-,24- WXXRNZHKHFPXPP-HSUQSKAJSA-N 50195302 4-{2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butyrylamino}-adamantane-1-carboxylic acid amide::CHEMBL374110 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195302&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11540493 104077371 CHEMBL374110 ZINC34632092 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360566 NC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C1CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C26H34F3N5O2/c27-26(28,29)19-3-4-20(31-14-19)33-5-7-34(8-6-33)22(16-1-2-16)23(35)32-21-17-9-15-10-18(21)13-25(11-15,12-17)24(30)36/h3-4,14-18,21-22H,1-2,5-13H2,(H2,30,36)(H,32,35)/t15?,17?,18?,21-,22?,25- XGRHLBPSNKYHEK-NNJMJYJPSA-N 50195301 4-{2-cyclopropyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetylamino}-adamantane-1-carboxylic acid amide::CHEMBL222618 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195301&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11649095 104077370 CHEMBL222618 ZINC35936880 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360571 NC(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C1(CCCC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C27H36F3N5O2/c28-27(29,30)20-3-4-21(32-16-20)34-7-9-35(10-8-34)26(5-1-2-6-26)24(37)33-22-18-11-17-12-19(22)15-25(13-17,14-18)23(31)36/h3-4,16-19,22H,1-2,5-15H2,(H2,31,36)(H,33,37)/t17?,18?,19?,22-,25- DGTYTWGBTCSTOI-TZKYZTEESA-N 50195286 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopentanecarbonyl}-amino)-adamantane-1-carboxylic acid amide::CHEMBL373792 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 50000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195286&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420244 104077355 CHEMBL373792 ZINC36286336 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356394 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ncc[nH]1 InChI=1S/C23H28ClN3O2/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)27-19-15-9-14-10-16(19)13-23(11-14,12-15)20-25-7-8-26-20/h3-8,14-16,19H,9-13H2,1-2H3,(H,25,26)(H,27,28)/t14-,15-,16?,19+,23+/m0/s1 XGDUOZKIZRASEM-XPFQKKRMSA-N 50192797 2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidazol-2-yl)-adamantan-2-yl]-2-methyl-propionamide::CHEMBL219137 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 11000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192797&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418452 104075598 CHEMBL219137 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356401 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nnc(N)[nH]1 InChI=1S/C22H28ClN5O2/c1-21(2,30-16-5-3-15(23)4-6-16)19(29)25-17-13-7-12-8-14(17)11-22(9-12,10-13)18-26-20(24)28-27-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,25,29)(H3,24,26,27,28)/t12-,13-,14?,17+,22+/m0/s1 ABFKDXBHEQHAFL-FWQQIOJYSA-N 50192787 CHEMBL219136::N-[(1R,2S,5S,7S)-5-(5-amino-4H-[1,2,4]triazol-3-yl)-adamantan-2-yl]-2-(4-chloro-phenoxy)-2-methyl-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 55000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192787&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418451 104075588 CHEMBL219136 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356402 CNc1ccc(cn1)C(C)(C)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C22H32N4O2/c1-21(2,16-4-5-18(24-3)25-12-16)20(28)26-19-14-6-13-7-15(19)10-22(8-13,9-14)11-17(23)27/h4-5,12-15,19H,6-11H2,1-3H3,(H2,23,27)(H,24,25)(H,26,28)/t13-,14-,15?,19+,22+/m0/s1 WRLITWGJOVVDNY-LDTIKURCSA-N 50192795 CHEMBL219081::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-(6-methylamino-pyridin-3-yl)-isobutyramide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192795&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418409 104075596 CHEMBL219081 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356407 CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(nc1)N1CCOCC1 InChI=1S/C25H36N4O3/c1-24(2,19-3-4-21(27-15-19)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1 BMMNJMWULKMUEW-GZHLDQJQSA-N 50192799 CHEMBL375979::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-(6-morpholin-4-yl-pyridin-3-yl)-isobutyramide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192799&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418408 104075600 CHEMBL375979 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356413 CC(C)(Oc1ccc(cn1)-n1cccn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C24H31N5O3/c1-23(2,32-20-5-4-18(14-26-20)29-7-3-6-27-29)22(31)28-21-16-8-15-9-17(21)12-24(10-15,11-16)13-19(25)30/h3-7,14-17,21H,8-13H2,1-2H3,(H2,25,30)(H,28,31)/t15-,16-,17?,21+,24+/m0/s1 NOWYWFGCVSZISC-KVKMBOCQSA-N 50192792 CHEMBL219348::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-2-(5-pyrazol-1-yl-pyridin-2-yloxy)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192792&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418400 104075593 CHEMBL219348 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356415 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](Cc1nnn[nH]1)(C3)C2 InChI=1S/C22H28ClN5O2/c1-21(2,30-17-5-3-16(23)4-6-17)20(29)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18-25-27-28-26-18/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,29)(H,25,26,27,28)/t13-,14-,15?,19+,22+/m0/s1 YBVGWBXXKAHRFL-LDTIKURCSA-N 50192789 2-(4-chloro-phenoxy)-2-methyl-N-[(1S,2S,5R,7S)-5-(1H-tetrazol-5-ylmethyl)-adamantan-2-yl]-propionamide::CHEMBL424931 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192789&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418384 104075590 CHEMBL424931 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356421 CC(C)(Oc1ccc(Br)cn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C21H28BrN3O3/c1-20(2,28-17-4-3-15(22)11-24-17)19(27)25-18-13-5-12-6-14(18)9-21(7-12,8-13)10-16(23)26/h3-4,11-14,18H,5-10H2,1-2H3,(H2,23,26)(H,25,27)/t12-,13-,14?,18+,21+/m0/s1 ZIMMKUOOHAWXLF-AYOVKPNZSA-N 50192791 2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL437522 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 49000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192791&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418390 104075592 CHEMBL437522 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356422 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(C#N)c(N)o1 InChI=1S/C24H27ClN4O3/c1-23(2,32-17-5-3-16(25)4-6-17)21(30)29-19-14-7-13-8-15(19)11-24(9-13,10-14)22-28-18(12-26)20(27)31-22/h3-6,13-15,19H,7-11,27H2,1-2H3,(H,29,30)/t13-,14-,15?,19+,24+/m0/s1 GTHCHCGWMUMNIC-QYZWLEAQSA-N 50192796 CHEMBL219575::N-[(1R,2S,5S,7S)-5-(5-amino-4-cyano-oxazol-2-yl)-adamantan-2-yl]-2-(4-chloro-phenoxy)-2-methyl-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192796&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418447 104075597 CHEMBL219575 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356423 CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(cn1)C#N InChI=1S/C22H28N4O2/c1-21(2,17-4-3-13(11-23)12-25-17)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-18(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1 ZFKLYMBYKJMHMS-ADYSRPFESA-N 50192798 CHEMBL219349::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-(5-cyano-pyridin-2-yl)-isobutyramide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192798&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418401 104075599 CHEMBL219349 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356432 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ccno1 InChI=1S/C23H27ClN2O3/c1-22(2,28-18-5-3-17(24)4-6-18)21(27)26-20-15-9-14-10-16(20)13-23(11-14,12-15)19-7-8-25-29-19/h3-8,14-16,20H,9-13H2,1-2H3,(H,26,27)/t14-,15-,16?,20+,23+/m0/s1 PLQQJMFGNKDHGI-IRTUOURPSA-N 50192800 2-(4-chloro-phenoxy)-N-((1R,2S,5S,7S)-5-isoxazol-5-yl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL219428 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 15000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192800&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418458 104075601 CHEMBL219428 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356434 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(O)=O)(C3)C2 InChI=1S/C22H28ClNO4/c1-21(2,28-17-5-3-16(23)4-6-17)20(27)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18(25)26/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,27)(H,25,26)/t13-,14-,15?,19+,22+/m0/s1 RKNILYVZCIUTKZ-LDTIKURCSA-N 50192801 CHEMBL220414::{(1R,4S,5R,7S)-4-[2-(4-chloro-phenoxy)-2-methyl-propionylamino]-adamantan-1-yl}-acetic acid 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 52000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192801&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418378 104075602 CHEMBL220414 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50356439 CC(C)(Oc1ccc(cn1)N1CCOCC1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2 InChI=1S/C25H36N4O4/c1-24(2,33-21-4-3-19(15-27-21)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1 PZSFNOREFIEVJQ-GZHLDQJQSA-N 50192786 CHEMBL216976::N-((1R,2S,5R,7S)-5-carbamoylmethyl-adamantan-2-yl)-2-methyl-2-(5-morphlin-4-yl-pyridin-2-yloxy)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.07.055 10.7270/Q28S4PJ0 16899366 Yeh, VS; Patel, JR; Yong, H; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Beno, D; Brune, M; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50192786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50192786&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418395 104075587 CHEMBL216976 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360572 NC(=O)[C@@]12C[C@H]3CC(C1)[C@@H](NC(=O)C1(CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C25H32F3N5O2/c26-25(27,28)18-1-2-19(30-14-18)32-5-7-33(8-6-32)24(3-4-24)22(35)31-20-16-9-15-10-17(20)13-23(11-15,12-16)21(29)34/h1-2,14-17,20H,3-13H2,(H2,29,34)(H,31,35)/t15-,16?,17?,20+,23- TZQSUCROPTURHG-XJWUCTIFSA-N 50195287 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopropanecarbonyl}-amino)-adamantane-1-carboxylic acid amide::CHEMBL376293 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195287&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11705872 104077356 CHEMBL376293 ZINC36286303 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360582 CC(C)(N1CCCCC1)C(=O)N[C@H]1C2C[C@H]3CC1C[C@](O)(C3)C2 InChI=1S/C19H32N2O2/c1-18(2,21-6-4-3-5-7-21)17(22)20-16-14-8-13-9-15(16)12-19(23,10-13)11-14/h13-16,23H,3-12H2,1-2H3,(H,20,22)/t13-,14?,15?,16-,19- QHTIJRCYQOYDKG-QVZPTTMKSA-N 50195304 CHEMBL220282::N-(5-hydroxy-adamantan-2-yl)-2-piperidin-1-yl-isobutyramide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3600 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195304&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420259 104077373 CHEMBL220282 ZINC36286356 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360584 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2C[C@H]3CC1C[C@](C3)(C2)C(O)=O InChI=1S/C25H33F3N4O3/c1-23(2,32-7-5-31(6-8-32)19-4-3-18(14-29-19)25(26,27)28)21(33)30-20-16-9-15-10-17(20)13-24(11-15,12-16)22(34)35/h3-4,14-17,20H,5-13H2,1-2H3,(H,30,33)(H,34,35)/t15-,16?,17?,20-,24- RVIKUVQZTJUNNT-HGYLWUCXSA-N 50195290 4-{2-methyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionylamino}-adamantane-1-carboxylic acid::CHEMBL376695 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 21000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195290&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11504178 104077359 CHEMBL376695 ZINC28604535 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360588 NC(=O)[C@@]12C[C@H]3CC(C1)[C@H](NC(=O)C1(CC1)N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C25H32F3N5O2/c26-25(27,28)18-1-2-19(30-14-18)32-5-7-33(8-6-32)24(3-4-24)22(35)31-20-16-9-15-10-17(20)13-23(11-15,12-16)21(29)34/h1-2,14-17,20H,3-13H2,(H2,29,34)(H,31,35)/t15-,16?,17?,20-,23- TZQSUCROPTURHG-LYGRSXDVSA-N 50195292 4-({1-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopropanecarbonyl}-amino)-adamantane-1-carboxylic acid amide::CHEMBL223804 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195292&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11705872 104077361 CHEMBL223804 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360590 O[C@@]12C[C@H]3CC(C1)[C@@H](NC(=O)C1(CC1)N1CCCCC1)C(C3)C2 InChI=1S/C19H30N2O2/c22-17(19(4-5-19)21-6-2-1-3-7-21)20-16-14-8-13-9-15(16)12-18(23,10-13)11-14/h13-16,23H,1-12H2,(H,20,22)/t13-,14?,15?,16+,18- CEZQNMXBDYZVET-VWOQGHHKSA-N 50195297 1-piperidin-1-yl-cyclopropanecarboxylic acid (5-hydroxy-adamantan-2-yl)-amide::CHEMBL221159 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.08.129 10.7270/Q23R0SJT 16996734 Sorensen, B; Rohde, J; Wang, J; Fung, S; Monzon, K; Chiou, W; Pan, L; Deng, X; Stolarik, D; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195297&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11666874 104077366 CHEMBL221159 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360711 CCOC(=O)CN1C[C@H](C)N([C@H](C)C1)C(=O)c1cc(Cl)c(N)c(Cl)c1 InChI=1S/C17H23Cl2N3O3/c1-4-25-15(23)9-21-7-10(2)22(11(3)8-21)17(24)12-5-13(18)16(20)14(19)6-12/h5-6,10-11H,4,7-9,20H2,1-3H3/t10-,11+ KVZJRHSMJYVALC-PHIMTYICSA-N 50195486 CHEMBL222317::ethyl 2-((3R,5S)-4-(4-amino-3,5-dichlorobenzoyl)-3,5-dimethylpiperazin-1-yl)acetate 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195486&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420233 104077487 CHEMBL222317 ZINC36286431 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360713 C[C@@H]1CC(C[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1)N1CCNC1=O InChI=1S/C17H22Cl2N4O2/c1-9-5-12(22-4-3-21-17(22)25)6-10(2)23(9)16(24)11-7-13(18)15(20)14(19)8-11/h7-10,12H,3-6,20H2,1-2H3,(H,21,25)/t9-,10-/m1/s1 NRUOIYWARKEXLI-NXEZZACHSA-N 50195484 1-((2R,6R)-1-(4-amino-3,5-dichlorobenzoyl)-2,6-dimethylpiperidin-4-yl)imidazolidin-2-one::CHEMBL374283 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195484&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420247 104077485 CHEMBL374283 ZINC36286466 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360720 Nc1c(Cl)cc(cc1Cl)C(=O)N1CC2CC1CN(Cc1ccccc1)C2 InChI=1S/C20H21Cl2N3O/c21-17-7-15(8-18(22)19(17)23)20(26)25-11-14-6-16(25)12-24(10-14)9-13-4-2-1-3-5-13/h1-5,7-8,14,16H,6,9-12,23H2 KTVCMHBTZGVJNN-UHFFFAOYSA-N 50195491 (4-amino-3,5-dichlorophenyl)(3-benzyl-3,6-diaza-bicyclo[3.2.1]octan-6-yl)methanone::CHEMBL220385 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195491&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420180 104077492 CHEMBL220385 ZINC36286473 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360732 C[C@H]1CN(C[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1)c1ccccn1 InChI=1S/C18H20Cl2N4O/c1-11-9-23(16-5-3-4-6-22-16)10-12(2)24(11)18(25)13-7-14(19)17(21)15(20)8-13/h3-8,11-12H,9-10,21H2,1-2H3/t11-,12+ REVBKPSDCXGBNR-TXEJJXNPSA-N 50195482 (4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethyl-4-(pyridin-2-yl)piperazin-1-yl)methanone::CHEMBL223373 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195482&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420232 104077483 CHEMBL223373 ZINC36286426 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360733 COC(=O)CN(C)C(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 InChI=1S/C21H27Cl2N3O4/c1-25(11-18(27)30-2)20(28)12-3-5-14(6-4-12)26(15-7-8-15)21(29)13-9-16(22)19(24)17(23)10-13/h9-10,12,14-15H,3-8,11,24H2,1-2H3/t12-,14+ DAEAJVPMQNJONR-XBXGTLAGSA-N 50195498 CHEMBL426208::methyl 2-((1s,4s)-4-(4-amino-3,5-dichloro-N-cyclopropylbenzamido)-N-methylcyclohexanecarboxamido)acetate 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195498&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420207 104077499 CHEMBL426208 ZINC36286416 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360738 CN(C(=O)c1cc(Cl)c(N)c(Cl)c1)C12CC3CC(CC(C3)C1)C2 InChI=1S/C18H22Cl2N2O/c1-22(17(23)13-5-14(19)16(21)15(20)6-13)18-7-10-2-11(8-18)4-12(3-10)9-18/h5-6,10-12H,2-4,7-9,21H2,1H3 YKQHBKKDQMAMNG-UHFFFAOYSA-N 50195483 CHEMBL373547::N-adamantan-1-yl-4-amino-3,5-dichloro-N-methyl-benzamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195483&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420164 104077484 CHEMBL373547 ZINC36286455 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360744 Nc1c(Cl)cc(cc1Cl)C(=O)N1CCN(CC1)c1ccc(cn1)C(F)(F)F InChI=1S/C17H15Cl2F3N4O/c18-12-7-10(8-13(19)15(12)23)16(27)26-5-3-25(4-6-26)14-2-1-11(9-24-14)17(20,21)22/h1-2,7-9H,3-6,23H2 RPLUJXKPOYQZGI-UHFFFAOYSA-N 50195500 (4-amino-3,5-dichlorophenyl)(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone::CHEMBL223424 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195500&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420252 104077501 CHEMBL223424 ZINC40584923 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360759 CCOC(=O)c1cccnc1N1C[C@H](C)N([C@H](C)C1)C(=O)c1cc(Cl)c(N)c(Cl)c1 InChI=1S/C21H24Cl2N4O3/c1-4-30-21(29)15-6-5-7-25-19(15)26-10-12(2)27(13(3)11-26)20(28)14-8-16(22)18(24)17(23)9-14/h5-9,12-13H,4,10-11,24H2,1-3H3/t12-,13+ OQNSPRXHGRSXHD-BETUJISGSA-N 50195505 CHEMBL223506::ethyl 2-((3R,5S)-4-(4-amino-3,5-dichlorobenzoyl)-3,5-dimethylpiperazin-1-yl)nicotinate 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195505&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420238 104077506 CHEMBL223506 ZINC36286445 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360760 COc1ccccc1N1C[C@H](C)N([C@H](C)C1)C(=O)c1cc(Cl)c(N)c(Cl)c1 InChI=1S/C20H23Cl2N3O2/c1-12-10-24(17-6-4-5-7-18(17)27-3)11-13(2)25(12)20(26)14-8-15(21)19(23)16(22)9-14/h4-9,12-13H,10-11,23H2,1-3H3/t12-,13+ MCGVBZPHMZCELG-BETUJISGSA-N 50195499 (4-amino-3,5-dichlorophenyl)((2R,6S)-4-(2-methoxyphenyl)-2,6-dimethylpiperazin-1-yl)methanone::CHEMBL222576 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195499&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420237 104077500 CHEMBL222576 ZINC36286440 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360773 Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)C1CCCC1 InChI=1S/C15H18Cl2N2O/c16-12-7-9(8-13(17)14(12)18)15(20)19(11-5-6-11)10-3-1-2-4-10/h7-8,10-11H,1-6,18H2 RMFVUUNCYRECJD-UHFFFAOYSA-N 50195487 4-amino-3,5-dichloro-N-cyclopentyl-N-cyclopropylbenzamide::CHEMBL220795 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195487&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420153 104077488 CHEMBL220795 ZINC36286437 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360775 Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)C(=O)NCc1ccccc1 InChI=1S/C24H27Cl2N3O2/c25-20-12-17(13-21(26)22(20)27)24(31)29(19-10-11-19)18-8-6-16(7-9-18)23(30)28-14-15-4-2-1-3-5-15/h1-5,12-13,16,18-19H,6-11,14,27H2,(H,28,30)/t16-,18+ JFHKVGDMKYWULR-MAEOIBBWSA-N 50195503 4-amino-N-((1s,4s)-4-(benzylcarbamoyl)cyclohexyl)-3,5-dichloro-N-cyclopropylbenzamide::CHEMBL222510 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195503&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420196 104077504 CHEMBL222510 ZINC36286413 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360781 C[C@H]1CN(C[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1)c1ncccc1N InChI=1S/C18H21Cl2N5O/c1-10-8-24(17-15(21)4-3-5-23-17)9-11(2)25(10)18(26)12-6-13(19)16(22)14(20)7-12/h3-7,10-11H,8-9,21-22H2,1-2H3/t10-,11+ IQEKKNIHTWIEQT-PHIMTYICSA-N 50195497 (4-amino-3,5-dichlorophenyl)((2R,6S)-4-(3-aminopyridin-2-yl)-2,6-dimethylpiperazin-1-yl)methanone::CHEMBL441553 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195497&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420242 104077498 CHEMBL441553 ZINC28604223 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360788 CN(C)CCNC(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 InChI=1S/C21H30Cl2N4O2/c1-26(2)10-9-25-20(28)13-3-5-15(6-4-13)27(16-7-8-16)21(29)14-11-17(22)19(24)18(23)12-14/h11-13,15-16H,3-10,24H2,1-2H3,(H,25,28)/t13-,15+ GFVRTRFRYFWAIJ-OTVXOJSOSA-N 50195488 CHEMBL374487::N-((1s,4s)-4-((2-(dimethylamino)ethyl)carbamoyl)cyclohexyl)-4-amino-3,5-dichloro-N-cyclopropylbenzamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195488&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420291 104077489 CHEMBL374487 ZINC36286433 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360790 CCOC(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 InChI=1S/C19H24Cl2N2O3/c1-2-26-19(25)11-3-5-13(6-4-11)23(14-7-8-14)18(24)12-9-15(20)17(22)16(21)10-12/h9-11,13-14H,2-8,22H2,1H3/t11-,13+ WKSREMNMLHZFGS-BJHJDKERSA-N 50195481 (1s,4s)-ethyl 4-(4-amino-3,5-dichloro-N-cyclopropylbenzamido)cyclohexanecarboxylate::CHEMBL376256 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195481&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420190 104077482 CHEMBL376256 ZINC36286410 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360791 Nc1c(Cl)cc(cc1Cl)C(=O)N1CCCN(Cc2ccccc2)CCC1 InChI=1S/C20H23Cl2N3O/c21-17-12-16(13-18(22)19(17)23)20(26)25-10-4-8-24(9-5-11-25)14-15-6-2-1-3-7-15/h1-3,6-7,12-13H,4-5,8-11,14,23H2 KBTSJKVYWPZTCV-UHFFFAOYSA-N 50195494 (4-amino-3,5-dichlorophenyl)(5-benzyl-1,5-diazocan-1-yl)methanone::CHEMBL220436 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195494&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420181 104077495 CHEMBL220436 ZINC36286476 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360798 Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)C(=O)N1CCCC1 InChI=1S/C21H27Cl2N3O2/c22-17-11-14(12-18(23)19(17)24)21(28)26(16-7-8-16)15-5-3-13(4-6-15)20(27)25-9-1-2-10-25/h11-13,15-16H,1-10,24H2/t13-,15+ AEMKILACVICPQY-OTVXOJSOSA-N 50195489 4-amino-3,5-dichloro-N-cyclopropyl-N-((1s,4s)-4-(pyrrolidine-1-carbonyl)cyclohexyl)benzamide::CHEMBL222256 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195489&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420215 104077490 CHEMBL222256 ZINC36286423 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360802 Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)C(=O)NCC1CCCCC1 InChI=1S/C24H33Cl2N3O2/c25-20-12-17(13-21(26)22(20)27)24(31)29(19-10-11-19)18-8-6-16(7-9-18)23(30)28-14-15-4-2-1-3-5-15/h12-13,15-16,18-19H,1-11,14,27H2,(H,28,30)/t16-,18+ OLMCJWZDIBDVMD-MAEOIBBWSA-N 50195502 CHEMBL221261::N-((1s,4s)-4-((cyclohexylmethyl)carbamoyl)cyclohexyl)-4-amino-3,5-dichloro-N-cyclopropylbenzamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195502&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420202 104077503 CHEMBL221261 ZINC40584160 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360806 C[C@@H]1C[C@@H](CCN1C(=O)c1cc(Cl)c(N)c(Cl)c1)n1c2ccccc2oc1=O InChI=1S/C20H19Cl2N3O3/c1-11-8-13(25-16-4-2-3-5-17(16)28-20(25)27)6-7-24(11)19(26)12-9-14(21)18(23)15(22)10-12/h2-5,9-11,13H,6-8,23H2,1H3/t11-,13-/m1/s1 HXIKSCJQFMRVPJ-DGCLKSJQSA-N 50195492 3-((2R,4R)-1-(4-amino-3,5-dichlorobenzoyl)-2-methylpiperidin-4-yl)benzo[d]oxazol-2(3H)-one::CHEMBL221158 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195492&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420243 104077493 CHEMBL221158 ZINC36286458 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360807 CC12CC(CC(C)(C)C1)N(C2)C(=O)c1cc(Cl)c(N)c(Cl)c1 InChI=1S/C17H22Cl2N2O/c1-16(2)6-11-7-17(3,8-16)9-21(11)15(22)10-4-12(18)14(20)13(19)5-10/h4-5,11H,6-9,20H2,1-3H3 XLNHYIWMMCYKBW-UHFFFAOYSA-N 50195504 (4-amino-3,5-dichlorophenyl)(1,3,3-trimethyl-6-aza-bicyclo[3.2.1]octan-6-yl)methanone::CHEMBL376087 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195504&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 16721119 104077505 CHEMBL376087 ZINC36286452 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360809 C[C@H]1CCC[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1 InChI=1S/C14H18Cl2N2O/c1-8-4-3-5-9(2)18(8)14(19)10-6-11(15)13(17)12(16)7-10/h6-9H,3-5,17H2,1-2H3/t8-,9+ QIIPLBRWXZECJB-DTORHVGOSA-N 50195496 (4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethylpiperidin-1-yl)methanone::CHEMBL222668 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195496&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420251 104077497 CHEMBL222668 ZINC36286479 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360812 C[C@@H]1CC(C[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1)n1c2ccccc2oc1=O InChI=1S/C21H21Cl2N3O3/c1-11-7-14(26-17-5-3-4-6-18(17)29-21(26)28)8-12(2)25(11)20(27)13-9-15(22)19(24)16(23)10-13/h3-6,9-12,14H,7-8,24H2,1-2H3/t11-,12-/m1/s1 QZRRAORQYWPWHA-VXGBXAGGSA-N 50195495 3-((2R,6R)-1-(4-amino-3,5-dichlorobenzoyl)-2,6-dimethylpiperidin-4-yl)benzo[d]oxazol-2(3H)-one::CHEMBL435136 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195495&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420246 104077496 CHEMBL435136 ZINC36286463 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360817 C[C@H]1CN(C[C@@H](C)N1C(=O)c1cc(Cl)c(N)c(Cl)c1)c1ccc(cn1)C(F)(F)F InChI=1S/C19H19Cl2F3N4O/c1-10-8-27(16-4-3-13(7-26-16)19(22,23)24)9-11(2)28(10)18(29)12-5-14(20)17(25)15(21)6-12/h3-7,10-11H,8-9,25H2,1-2H3/t10-,11+ WXTCOPGFTLXKPA-PHIMTYICSA-N 50195507 (4-amino-3,5-dichlorophenyl)((2R,6S)-2,6-dimethyl-4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone::CHEMBL223507 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195507&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420257 104077508 CHEMBL223507 ZINC36286485 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360819 Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)C(=O)NCC(O)=O InChI=1S/C19H23Cl2N3O4/c20-14-7-11(8-15(21)17(14)22)19(28)24(13-5-6-13)12-3-1-10(2-4-12)18(27)23-9-16(25)26/h7-8,10,12-13H,1-6,9,22H2,(H,23,27)(H,25,26)/t10-,12+ PIVHVYCTSLIOPL-KLPPZKSPSA-N 50195490 2-((1s,4s)-4-(4-amino-3,5-dichloro-N-cyclopropylbenzamido)cyclohexanecarboxamido)acetic acid::CHEMBL374318 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195490&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420212 104077491 CHEMBL374318 ZINC36286419 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360821 Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)C1CCCCC1 InChI=1S/C16H20Cl2N2O/c17-13-8-10(9-14(18)15(13)19)16(21)20(12-6-7-12)11-4-2-1-3-5-11/h8-9,11-12H,1-7,19H2 QEQGDIDGXMCVHA-UHFFFAOYSA-N 50195485 4-amino-3,5-dichloro-N-cyclohexyl-N-cyclopropylbenzamide::CHEMBL219666 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195485&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420186 104077486 CHEMBL219666 ZINC36286482 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360822 CN1CCN(CC1)C(=O)[C@@H]1CC[C@@H](CC1)N(C1CC1)C(=O)c1cc(Cl)c(N)c(Cl)c1 InChI=1S/C22H30Cl2N4O2/c1-26-8-10-27(11-9-26)21(29)14-2-4-16(5-3-14)28(17-6-7-17)22(30)15-12-18(23)20(25)19(24)13-15/h12-14,16-17H,2-11,25H2,1H3/t14-,16+ DFNPIZUBHLSPSK-FZNQNYSPSA-N 50195493 4-amino-3,5-dichloro-N-cyclopropyl-N-((1s,4s)-4-(1-methylpiperazine-4-carbonyl)cyclohexyl)benzamide::CHEMBL219784 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195493&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420288 104077494 CHEMBL219784 ZINC28604168 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360823 Nc1c(Cl)cc(cc1Cl)C(=O)N1C2CC3CC(C2)CC1C3 InChI=1S/C16H18Cl2N2O/c17-13-6-10(7-14(18)15(13)19)16(21)20-11-2-8-1-9(4-11)5-12(20)3-8/h6-9,11-12H,1-5,19H2 WOEHKTBKVZANJD-UHFFFAOYSA-N 50195506 (4-amino-3,5-dichloro-phenyl)-(2-aza-tricyclo[3.3.1.1*3,7*]dec-2-yl)-methanone::CHEMBL222938 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195506&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420166 104077507 CHEMBL222938 ZINC36286461 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50360784 Nc1c(Cl)cc(cc1Cl)C(=O)N1CCCCC1 InChI=1S/C12H14Cl2N2O/c13-9-6-8(7-10(14)11(9)15)12(17)16-4-2-1-3-5-16/h6-7H,1-5,15H2 UWAXTHRVVZSQGM-UHFFFAOYSA-N 50195501 (4-amino-3,5-dichlorophenyl)(piperidin-1-yl)methanone::CHEMBL219614 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.09.035 10.7270/Q2B857R4 17000111 Richards, S; Sorensen, B; Jae, HS; Winn, M; Chen, Y; Wang, J; Fung, S; Monzon, K; Frevert, EU; Jacobson, P; Sham, H; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195501&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44420248 104077502 CHEMBL219614 ZINC36286470 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357720 CC1(C)C(COc2ccc(cc2)-n2ccnc2)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)C1=O InChI=1S/C27H34N4O3/c1-26(2)20(15-34-22-5-3-21(4-6-22)30-8-7-29-16-30)14-31(25(26)33)23-18-9-17-10-19(23)13-27(11-17,12-18)24(28)32/h3-8,16-20,23H,9-15H2,1-2H3,(H2,28,32)/t17?,18?,19?,20?,23-,27- AVSHDHHSWZFVQY-JTBBFVBSSA-N 50193784 4-[4-(4-imidazol-1-yl-phenoxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-adamantane-1-carboxylic acid amide::CHEMBL218120 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1800 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193784&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24890070 104076180 CHEMBL218120 ZINC28604038 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357734 CC1(C)C(COc2ccc(cn2)C#N)CN(C2CCCCCC2)C1=O InChI=1S/C20H27N3O2/c1-20(2)16(14-25-18-10-9-15(11-21)12-22-18)13-23(19(20)24)17-7-5-3-4-6-8-17/h9-10,12,16-17H,3-8,13-14H2,1-2H3 IIOIWTHGGFXVPM-UHFFFAOYSA-N 50193790 6-((1-cycloheptyl-4,4-dimethyl-5-oxopyrrolidin-3-yl)methoxy)nicotinonitrile::CHEMBL384650 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193790&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889741 104076186 CHEMBL384650 ZINC36286276 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357738 O=C1C(Cc2ccccc2)CCN1C1CCCCC1 InChI=1S/C17H23NO/c19-17-15(13-14-7-3-1-4-8-14)11-12-18(17)16-9-5-2-6-10-16/h1,3-4,7-8,15-16H,2,5-6,9-13H2 DGGDICYTCJZLPW-UHFFFAOYSA-N 50193792 3-benzyl-1-cyclohexylpyrrolidin-2-one::CHEMBL218285 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193792&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11673314 104076188 CHEMBL218285 ZINC36286396 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357748 CC1(C)C(COc2ccc(cn2)C#N)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)C1=O InChI=1S/C24H30N4O3/c1-23(2)18(13-31-19-4-3-14(10-25)11-27-19)12-28(22(23)30)20-16-5-15-6-17(20)9-24(7-15,8-16)21(26)29/h3-4,11,15-18,20H,5-9,12-13H2,1-2H3,(H2,26,29)/t15?,16?,17?,18?,20-,24- OHFPORFQCIWVDI-NFAVILPFSA-N 50193786 4-[4-(5-cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-adamantane-1-carboxylic acid amide::CHEMBL219049 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 23000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193786&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24890239 104076182 CHEMBL219049 ZINC35049141 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357749 CCOC(=O)[C@@H]1[C@H]2CCC(CC[C@@H]12)N1CC(COc2ccc(cn2)C#N)C(C)(C)C1=O InChI=1S/C24H31N3O4/c1-4-30-22(28)21-18-8-6-17(7-9-19(18)21)27-13-16(24(2,3)23(27)29)14-31-20-10-5-15(11-25)12-26-20/h5,10,12,16-19,21H,4,6-9,13-14H2,1-3H3/t16?,17?,18-,19+,21+ WQKGQPVBVCVYEK-IZHWVNFWSA-N 50193783 (1R,7S,8r)-ethyl 4-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[5.1.0]octane-8-carboxylate::CHEMBL218943 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193783&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889907 104076179 CHEMBL218943 ZINC36286222 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357752 NC(=O)[C@@]12CC3CC(C1)[C@@H](C(C3)C2)N1CCC(Cc2ccccc2)C1=O InChI=1S/C22H28N2O2/c23-21(26)22-11-15-9-17(12-22)19(18(10-15)13-22)24-7-6-16(20(24)25)8-14-4-2-1-3-5-14/h1-5,15-19H,6-13H2,(H2,23,26)/t15?,16?,17?,18?,19-,22- GRPWDRHUGPCUBI-MMSGYNQISA-N 50193797 4-(3-benzyl-2-oxo-pyrrolidin-1-yl)-adamantane-1-carboxylic acid amide::CHEMBL221132 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193797&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44419286 104076193 CHEMBL221132 ZINC36286407 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357758 CC1(C)C(COc2ccc(cn2)C#N)CN([C@H]2C3CCCC2C[C@H](C3)C(N)=O)C1=O InChI=1S/C23H30N4O3/c1-23(2)18(13-30-19-7-6-14(10-24)11-26-19)12-27(22(23)29)20-15-4-3-5-16(20)9-17(8-15)21(25)28/h6-7,11,15-18,20H,3-5,8-9,12-13H2,1-2H3,(H2,25,28)/t15?,16?,17-,18?,20- FPMIUFVSNVJQNM-ZIOKKRPGSA-N 50193785 (3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL221284 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 15000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193785&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889906 104076181 CHEMBL221284 ZINC35049139 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357765 CC1(C)C(COc2ccc(cn2)C#N)CN([C@@H]2C3CCCC2C[C@H](C3)C(N)=O)C1=O InChI=1S/C23H30N4O3/c1-23(2)18(13-30-19-7-6-14(10-24)11-26-19)12-27(22(23)29)20-15-4-3-5-16(20)9-17(8-15)21(25)28/h6-7,11,15-18,20H,3-5,8-9,12-13H2,1-2H3,(H2,25,28)/t15?,16?,17-,18?,20+ FPMIUFVSNVJQNM-VRYLTXLISA-N 50193788 (3s,9s)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL218119 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193788&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889906 104076184 CHEMBL218119 ZINC35049139 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357767 CC1(C)C(COc2ccc(cn2)C(F)(F)F)CN([C@H]2C3CC4CC2C[C@](C4)(C3)c2nnn[nH]2)C1=O InChI=1S/C24H29F3N6O2/c1-22(2)17(12-35-18-4-3-16(10-28-18)24(25,26)27)11-33(21(22)34)19-14-5-13-6-15(19)9-23(7-13,8-14)20-29-31-32-30-20/h3-4,10,13-15,17,19H,5-9,11-12H2,1-2H3,(H,29,30,31,32)/t13?,14?,15?,17?,19-,23- JIPIIKUPMSVLEL-WFEZEDJFSA-N 50193796 3,3-dimethyl-1-[5-(1H-tetrazol-5-yl)-adamantan-2-yl]-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-2-one::CHEMBL218570 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 630 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193796&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44419313 104076192 CHEMBL218570 ZINC36286269 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357768 CC1(C)C(COc2ccc(cn2)C(F)(F)F)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(=N)NO)C1=O InChI=1S/C24H31F3N4O3/c1-22(2)17(12-34-18-4-3-16(10-29-18)24(25,26)27)11-31(21(22)32)19-14-5-13-6-15(19)9-23(7-13,8-14)20(28)30-33/h3-4,10,13-15,17,19,33H,5-9,11-12H2,1-2H3,(H2,28,30)/t13?,14?,15?,17?,19-,23- UZCSLSQPVOHMEK-WFEZEDJFSA-N 50193787 4-[3,3-dmethyl-2-oxo-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-1-yl]-N-hydroxy-adamantane-1-carboxamidine::CHEMBL267734 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 14000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193787&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44419309 104076183 CHEMBL267734 ZINC36286262 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357769 CC1(C)C(COc2ccc(cc2)-n2cncn2)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)C1=O InChI=1S/C26H33N5O3/c1-25(2)19(13-34-21-5-3-20(4-6-21)31-15-28-14-29-31)12-30(24(25)33)22-17-7-16-8-18(22)11-26(9-16,10-17)23(27)32/h3-6,14-19,22H,7-13H2,1-2H3,(H2,27,32)/t16?,17?,18?,19?,22-,26- NQCWDFHXAMUWTF-HCGXBOKKSA-N 50193789 4-[3,3-dimethyl-2-oxo-4-(4-[1,2,4]triazol-1-yl-phenoxymethyl)-pyrrolidin-1-yl]-adamantane-1-carboxylic acid amide::CHEMBL385777 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193789&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24890069 104076185 CHEMBL385777 ZINC36286255 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357771 CC1(C)C(COc2ccc(cn2)C#N)CN([C@H]2C3CCCC2C[C@H](C3)C(N)=O)C1=O InChI=1S/C23H30N4O3/c1-23(2)18(13-30-19-7-6-14(10-24)11-26-19)12-27(22(23)29)20-15-4-3-5-16(20)9-17(8-15)21(25)28/h6-7,11,15-18,20H,3-5,8-9,12-13H2,1-2H3,(H2,25,28)/t15?,16?,17-,18?,20- FPMIUFVSNVJQNM-ZIOKKRPGSA-N 50193785 (3r,9r)-9-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide::CHEMBL221284 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 15000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193785&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24889906 104076181 CHEMBL221284 ZINC35049139 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357775 O=C1C(Cc2ccccc2)CCN1[C@H]1C2CC3CC(C2)CC1C3 InChI=1S/C21H27NO/c23-21-17(9-14-4-2-1-3-5-14)6-7-22(21)20-18-10-15-8-16(12-18)13-19(20)11-15/h1-5,15-20H,6-13H2/t15?,16?,17?,18?,19?,20- HAAVSDQVLBVURQ-FYGPYCFWSA-N 50193799 1-(2-adamantyl)-3-benzylpyrrolidin-2-one::CHEMBL218286 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193799&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44419251 104076195 CHEMBL218286 ZINC36286401 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357777 O[C@@]12CC3CC(C1)[C@@H](C(C3)C2)N1CCC(Cc2ccccc2)C1=O InChI=1S/C21H27NO2/c23-20-16(8-14-4-2-1-3-5-14)6-7-22(20)19-17-9-15-10-18(19)13-21(24,11-15)12-17/h1-5,15-19,24H,6-13H2/t15?,16?,17?,18?,19-,21- YEQILGCMSYLJDM-SXEMINFMSA-N 50193794 3-benzyl-1-(5-hydroxy-adamantan-2-yl)-pyrrolidin-2-one::CHEMBL376306 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193794&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11551576 104076190 CHEMBL376306 ZINC35788736 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357788 CC1(C)C(COc2ccc(cn2)C(F)(F)F)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=N)C1=O InChI=1S/C24H31F3N4O2/c1-22(2)17(12-33-18-4-3-16(10-30-18)24(25,26)27)11-31(21(22)32)19-14-5-13-6-15(19)9-23(7-13,8-14)20(28)29/h3-4,10,13-15,17,19H,5-9,11-12H2,1-2H3,(H3,28,29)/t13?,14?,15?,17?,19-,23- DIFGDVMRNDYUGR-WFEZEDJFSA-N 50193791 4-[3,3-dimethyl-2-oxo-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-1-yl]-adamantane-1-carboxamidine::CHEMBL376226 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 90000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193791&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24890073 104076187 CHEMBL376226 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50357790 CC1(C)C(COc2ccc(cn2)C#N)CN(C1=O)C12CCC(CC1)(CC2)C(N)=O InChI=1S/C22H28N4O3/c1-20(2)16(14-29-17-4-3-15(11-23)12-25-17)13-26(19(20)28)22-8-5-21(6-9-22,7-10-22)18(24)27/h3-4,12,16H,5-10,13-14H2,1-2H3,(H2,24,27) RIECCHAKVDPPHN-UHFFFAOYSA-N 50193795 34-(4-((5-cyanopyridin-2-yloxy)methyl)-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[2.2.2]octane-1-carboxamide::CHEMBL218569 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 17000 ChEMBL 10.1016/j.bmcl.2006.08.034 10.7270/Q25X28K5 16931002 Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193795&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44419304 104076191 CHEMBL218569 ZINC36286246 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363846 CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H27ClN2O4S/c1-19(2,27-16-6-4-3-5-15(16)21)18(24)23-17-13-7-12-8-14(17)11-20(9-12,10-13)28(22,25)26/h3-6,12-14,17H,7-11H2,1-2H3,(H,23,24)(H2,22,25,26)/t12?,13?,14?,17-,20- IKXWOMITWYKYSN-OQZFIPPTSA-N 50197399 2-(2-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL239373 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 5500 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197399&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11618761 104078780 CHEMBL239373 ZINC28883357 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363847 COc1cc(F)ccc1OC(C)(C)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C22H30FNO5S/c1-21(2,29-17-6-5-16(23)9-18(17)28-3)20(25)24-19-14-7-13-8-15(19)12-22(10-13,11-14)30(4,26)27/h5-6,9,13-15,19H,7-8,10-12H2,1-4H3,(H,24,25)/t13?,14?,15?,19-,22- OXJFVFXQQOZVHD-TXBRZDKCSA-N 50197400 2-(4-fluoro-2-methoxy-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL240622 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197400&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438677 104078781 CHEMBL240622 ZINC28883302 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363848 CC(C)(Oc1ccccc1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H28N2O4S/c1-19(2,26-16-6-4-3-5-7-16)18(23)22-17-14-8-13-9-15(17)12-20(10-13,11-14)27(21,24)25/h3-7,13-15,17H,8-12H2,1-2H3,(H,22,23)(H2,21,24,25)/t13?,14?,15?,17-,20- RJFGXRMIXRFUOJ-UMTQXKRCSA-N 50197401 2-methyl-2-phenoxy-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL241719 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 59000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438679 104078782 CHEMBL241719 ZINC28883342 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363851 CC(C)(Oc1c(Cl)cc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H25Cl2FN2O4S/c1-19(2,29-17-14(21)5-13(23)6-15(17)22)18(26)25-16-11-3-10-4-12(16)9-20(7-10,8-11)30(24,27)28/h5-6,10-12,16H,3-4,7-9H2,1-2H3,(H,25,26)(H2,24,27,28)/t10?,11?,12?,16-,20- VUGLQUSKDGVICM-LBZAOVANSA-N 50197404 2-(2,6-dichloro-4-fluoro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL391653 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 9000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197404&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438682 104078785 CHEMBL391653 ZINC28883488 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363853 CN(C)S(=O)(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)C(C3)C2 InChI=1S/C22H31ClN2O4S/c1-21(2,29-18-7-5-17(23)6-8-18)20(26)24-19-15-9-14-10-16(19)13-22(11-14,12-15)30(27,28)25(3)4/h5-8,14-16,19H,9-13H2,1-4H3,(H,24,26)/t14?,15?,16?,19-,22- VJHGNFUYSRHHAB-IDNYSXLCSA-N 50197406 2-(4-chloro-phenoxy)-N-(5-dimethylsulfamoyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL246442 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 60000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197406&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11712182 104078787 CHEMBL246442 ZINC28883404 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363855 CC(C)(Oc1ccccc1C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C22H28F3NO4S/c1-20(2,30-17-7-5-4-6-16(17)22(23,24)25)19(27)26-18-14-8-13-9-15(18)12-21(10-13,11-14)31(3,28)29/h4-7,13-15,18H,8-12H2,1-3H3,(H,26,27)/t13?,14?,15?,18-,21- HFZMOPIOWUPSSE-YLGPJNIESA-N 50197403 CHEMBL393167::N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-2-(2-trifluoromethyl-phenoxy)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197403&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438676 104078784 CHEMBL393167 ZINC28883280 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363870 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(=O)(=O)CCCN1CCOCC1 InChI=1S/C27H38ClFN2O5S/c1-26(2,36-23-5-4-21(29)14-22(23)28)25(32)30-24-19-12-18-13-20(24)17-27(15-18,16-19)37(33,34)11-3-6-31-7-9-35-10-8-31/h4-5,14,18-20,24H,3,6-13,15-17H2,1-2H3,(H,30,32)/t18?,19?,20?,24-,27- HVKZAAMCWANHEW-GIHQTTFSSA-N 50197407 2-(2-chloro-4-fluoro-phenoxy)-2-methyl-N-[5-(3-morpholin-4-yl-propane-1-sulfonyl)-adamantan-2-yl]-propionamide::CHEMBL240619 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 15000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197407&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438671 104078788 CHEMBL240619 ZINC28883230 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363872 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H27ClN2O4S/c1-19(2,27-16-5-3-4-15(21)8-16)18(24)23-17-13-6-12-7-14(17)11-20(9-12,10-13)28(22,25)26/h3-5,8,12-14,17H,6-7,9-11H2,1-2H3,(H,23,24)(H2,22,25,26)/t12?,13?,14?,17-,20- ZZXWSNKEDMSRRS-OQZFIPPTSA-N 50197408 2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL399191 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 6300 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197408&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11502804 104078789 CHEMBL399191 ZINC28883372 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363884 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H27ClFNO4S/c1-20(2,28-17-5-4-15(23)8-16(17)22)19(25)24-18-13-6-12-7-14(18)11-21(9-12,10-13)29(3,26)27/h4-5,8,12-14,18H,6-7,9-11H2,1-3H3,(H,24,25)/t12?,13?,14?,18-,21- ULLPKOZNMAWTIP-RXAJHBGNSA-N 50197414 2-(2-chloro-4-fluoro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241707 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 26000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197414&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11655188 104078795 CHEMBL241707 ZINC16052179 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363886 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H28ClNO4S/c1-20(2,27-17-6-4-16(22)5-7-17)19(24)23-18-14-8-13-9-15(18)12-21(10-13,11-14)28(3,25)26/h4-7,13-15,18H,8-12H2,1-3H3,(H,23,24)/t13?,14?,15?,18-,21- RSHUECPBXOMFTQ-YLGPJNIESA-N 50197405 2-(4-chloro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241716 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 65000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197405&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438675 104078786 CHEMBL241716 ZINC28883271 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363887 CC(C)(C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O)c1ccccc1 InChI=1S/C20H28N2O3S/c1-19(2,16-6-4-3-5-7-16)18(23)22-17-14-8-13-9-15(17)12-20(10-13,11-14)26(21,24)25/h3-7,13-15,17H,8-12H2,1-2H3,(H,22,23)(H2,21,24,25)/t13?,14?,15?,17-,20- NNKZNDAYDMLMIA-UMTQXKRCSA-N 50197411 2-phenyl-N-(5-sulfamoyl-adamantan-2-yl)-isobutyramide::CHEMBL391447 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197411&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438681 104078792 CHEMBL391447 ZINC28883442 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363890 CC(C)(Oc1ccccc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H28ClNO4S/c1-20(2,27-17-7-5-4-6-16(17)22)19(24)23-18-14-8-13-9-15(18)12-21(10-13,11-14)28(3,25)26/h4-7,13-15,18H,8-12H2,1-3H3,(H,23,24)/t13?,14?,15?,18-,21- BOJWTWDRXNJANH-YLGPJNIESA-N 50197418 2-(2-chloro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL394217 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 5400 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197418&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438672 104078799 CHEMBL394217 ZINC28883244 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363895 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(=O)(=O)CC(N)=O InChI=1S/C22H28ClFN2O5S/c1-21(2,31-17-4-3-15(24)7-16(17)23)20(28)26-19-13-5-12-6-14(19)10-22(8-12,9-13)32(29,30)11-18(25)27/h3-4,7,12-14,19H,5-6,8-11H2,1-2H3,(H2,25,27)(H,26,28)/t12?,13?,14?,19-,22- PEERJNNYPXHLDJ-JPWRKOPWSA-N 50197412 CHEMBL241711::N-(5-carbamoylmethanesulfonyl-adamantan-2-yl)-2-(2-chloro-4-fluoro-phenoxy)-2-methyl-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3300 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197412&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438670 104078793 CHEMBL241711 ZINC28883197 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363897 CCS(=O)(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C)(C)Oc1ccc(F)cc1Cl)C(C3)C2 InChI=1S/C22H29ClFNO4S/c1-4-30(27,28)22-10-13-7-14(11-22)19(15(8-13)12-22)25-20(26)21(2,3)29-18-6-5-16(24)9-17(18)23/h5-6,9,13-15,19H,4,7-8,10-12H2,1-3H3,(H,25,26)/t13?,14?,15?,19-,22- BPIBIOIIJZPFME-TXBRZDKCSA-N 50197409 2-(2-chloro-4-fluoro-phenoxy)-N-(5-ethanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241709 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 15000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197409&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438669 104078790 CHEMBL241709 ZINC28883181 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363899 CC(C)(Oc1ccccc1OC(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C21H27F3N2O5S/c1-19(2,30-15-5-3-4-6-16(15)31-21(22,23)24)18(27)26-17-13-7-12-8-14(17)11-20(9-12,10-13)32(25,28)29/h3-6,12-14,17H,7-11H2,1-2H3,(H,26,27)(H2,25,28,29)/t12?,13?,14?,17-,20- KBPAWKAPWANKIO-OQZFIPPTSA-N 50197410 2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-2-(2-trifluoromethoxy-phenoxy)-propionamide::CHEMBL246858 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 25000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197410&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11576524 104078791 CHEMBL246858 ZINC28883458 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363900 CC(C)(Oc1ccc(Cl)cc1F)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H27ClFNO4S/c1-20(2,28-17-5-4-15(22)8-16(17)23)19(25)24-18-13-6-12-7-14(18)11-21(9-12,10-13)29(3,26)27/h4-5,8,12-14,18H,6-7,9-11H2,1-3H3,(H,24,25)/t12?,13?,14?,18-,21- AGGRAAZXMDOZHP-RXAJHBGNSA-N 50197417 2-(4-chloro-2-fluoro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241717 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 21000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197417&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438678 104078798 CHEMBL241717 ZINC28883322 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363903 CC(C)(Oc1ccc(F)cc1Cl)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H26ClFN2O4S/c1-19(2,28-16-4-3-14(22)7-15(16)21)18(25)24-17-12-5-11-6-13(17)10-20(8-11,9-12)29(23,26)27/h3-4,7,11-13,17H,5-6,8-10H2,1-2H3,(H,24,25)(H2,23,26,27)/t11?,12?,13?,17-,20- SKQLNVOBAKAAKC-LURQHNEFSA-N 50197416 2-(2-chloro-4-fluoro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL391652 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197416&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11510573 104078797 CHEMBL391652 ZINC28883473 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363904 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(C)(=O)=O InChI=1S/C21H28ClNO4S/c1-20(2,27-17-6-4-5-16(22)9-17)19(24)23-18-14-7-13-8-15(18)12-21(10-13,11-14)28(3,25)26/h4-6,9,13-15,18H,7-8,10-12H2,1-3H3,(H,23,24)/t13?,14?,15?,18-,21- ALYTWLIPCNGVIJ-YLGPJNIESA-N 50197413 2-(3-chloro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide::CHEMBL241714 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 17000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197413&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44438673 104078794 CHEMBL241714 ZINC28883252 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363908 CNS(=O)(=O)[C@@]12CC3CC(C1)[C@H](NC(=O)C(C)(C)Oc1ccc(Cl)cc1)C(C3)C2 InChI=1S/C21H29ClN2O4S/c1-20(2,28-17-6-4-16(22)5-7-17)19(25)24-18-14-8-13-9-15(18)12-21(10-13,11-14)29(26,27)23-3/h4-7,13-15,18,23H,8-12H2,1-3H3,(H,24,25)/t13?,14?,15?,18-,21- LAWOOLSGJUVOSC-YLGPJNIESA-N 50197419 2-(4-chloro-phenoxy)-2-methyl-N-(5-methylsulfamoyl-adamantan-2-yl)-propionamide::CHEMBL392913 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 85000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197419&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11626362 104078800 CHEMBL392913 ZINC28883385 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50363920 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)S(N)(=O)=O InChI=1S/C20H27ClN2O4S/c1-19(2,27-16-5-3-15(21)4-6-16)18(24)23-17-13-7-12-8-14(17)11-20(9-12,10-13)28(22,25)26/h3-6,12-14,17H,7-11H2,1-2H3,(H,23,24)(H2,22,25,26)/t12?,13?,14?,17-,20- MEKFEFJATTVXSH-OQZFIPPTSA-N 50197402 2-(4-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide::CHEMBL392932 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 16000 ChEMBL 10.1016/j.bmcl.2006.10.008 10.7270/Q2BZ65PP 17070044 Sorensen, B; Winn, M; Rohde, J; Shuai, Q; Wang, J; Fung, S; Monzon, K; Chiou, W; Stolarik, D; Imade, H; Pan, L; Deng, X; Chovan, L; Longenecker, K; Judge, R; Qin, W; Brune, M; Camp, H; Frevert, EU; Jacobson, P; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50197402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50197402&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11604308 104078783 CHEMBL392932 ZINC28883544 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370413 O[C@@]12CC3CC(C1)[C@H](NC(=O)CN1CC[C@@H](C1)C(F)(F)F)C(C3)C2 InChI=1S/C17H25F3N2O2/c18-17(19,20)13-1-2-22(8-13)9-14(23)21-15-11-3-10-4-12(15)7-16(24,5-10)6-11/h10-13,15,24H,1-9H2,(H,21,23)/t10?,11?,12?,13-,15-,16-/m0/s1 YCPHGDKLMMKHEC-FRWGEJJCSA-N 50202094 CHEMBL375341::N-(5-hydroxy-adamantan-2-yl)-2-(3-trifluoromethyl-pyrrolidin-1-yl)-acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202094&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418821 104081723 CHEMBL375341 ZINC35087382 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370415 O[C@]12CC3CC(C1)[C@H](NC(=O)CN1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C22H29F3N4O2/c23-22(24,25)17-1-2-18(26-12-17)29-5-3-28(4-6-29)13-19(30)27-20-15-7-14-8-16(20)11-21(31,9-14)10-15/h1-2,12,14-16,20,31H,3-11,13H2,(H,27,30)/t14?,15?,16?,20-,21+ PSFYSFYPFBYYCS-JXJPVIIGSA-N 50202089 CHEMBL373889::N-[(Z)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202089&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11495851 104081718 CHEMBL373889 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370421 FC(F)(F)c1ccc(nc1)N1CCN(CC(=O)N[C@H]2C3CC4CC2C[C@@](F)(C4)C3)CC1 InChI=1S/C22H28F4N4O/c23-21-9-14-7-15(10-21)20(16(8-14)11-21)28-19(31)13-29-3-5-30(6-4-29)18-2-1-17(12-27-18)22(24,25)26/h1-2,12,14-16,20H,3-11,13H2,(H,28,31)/t14?,15?,16?,20-,21+ RUBWTVFAHWBQIP-JXJPVIIGSA-N 50202099 CHEMBL218358::N-[(Z)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202099&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11655097 104081728 CHEMBL218358 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370423 CC(N1CCc2ccc3OCOc3c2CC1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C24H32N2O4/c1-14(23(27)25-21-17-8-15-9-18(21)12-24(28,10-15)11-17)26-6-4-16-2-3-20-22(30-13-29-20)19(16)5-7-26/h2-3,14-15,17-18,21,28H,4-13H2,1H3,(H,25,27)/t14?,15?,17?,18?,21-,24- BPEXEDGEGUHCBA-WDOFSTQFSA-N 50202087 CHEMBL374728::N-[(1R,3S)-5-hydroxy-2-adamantyl]-2-(6,7,9,10-tetrahydro-8H-[1,3]dioxolo[4,5-g][3]benzazepin-8-yl)propanamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 62000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202087&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418857 104081716 CHEMBL374728 ZINC35087400 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370432 OC12CC3CC(CC(C3)C1NC(=O)CN1CCN(CC1)c1ccc(cn1)C(F)(F)F)C2 InChI=1S/C22H29F3N4O2/c23-22(24,25)17-1-2-18(26-12-17)29-5-3-28(4-6-29)13-19(30)27-20-16-8-14-7-15(9-16)11-21(20,31)10-14/h1-2,12,14-16,20,31H,3-11,13H2,(H,27,30) HDLZHQFBHVJHLK-UHFFFAOYSA-N 50202098 CHEMBL218143::N-(1-hydroxy-adamantan-2-yl)-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202098&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418817 104081727 CHEMBL218143 ZINC35087349 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370438 O=C(CN1CCN(CC1)c1ncccc1C#N)NC1C2CC3CC(C2)CC1C3 InChI=1S/C22H29N5O/c23-13-17-2-1-3-24-22(17)27-6-4-26(5-7-27)14-20(28)25-21-18-9-15-8-16(11-18)12-19(21)10-15/h1-3,15-16,18-19,21H,4-12,14H2,(H,25,28) LTTIAASWMSZBDG-UHFFFAOYSA-N 50202091 CHEMBL384364::N-adamantan-2-yl-2-[4-(3-cyano-pyridin-2-yl)-piperazin-1-yl]-acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202091&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10452320 104081720 CHEMBL384364 ZINC36286212 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370440 CC(C)(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C24H33F3N4O2/c1-22(2,21(32)29-20-16-9-15-10-17(20)13-23(33,11-15)12-16)31-7-5-30(6-8-31)19-4-3-18(14-28-19)24(25,26)27/h3-4,14-17,20,33H,5-13H2,1-2H3,(H,29,32)/t15?,16?,17?,20-,23- QTLNSFMROWVHJU-KOVCZQLCSA-N 50202097 CHEMBL424937::N-[(E)-5-hydroxy-2-adamantyl]-2-methyl-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propanamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202097&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11634114 104081726 CHEMBL424937 ZINC35974253 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370474 O[C@@]12CC3CC(C1)[C@H](NC(=O)CN1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(C3)C2 InChI=1S/C22H29F3N4O2/c23-22(24,25)17-1-2-18(26-12-17)29-5-3-28(4-6-29)13-19(30)27-20-15-7-14-8-16(20)11-21(31,9-14)10-15/h1-2,12,14-16,20,31H,3-11,13H2,(H,27,30)/t14?,15?,16?,20-,21- PSFYSFYPFBYYCS-VWPUDVFHSA-N 50202086 CHEMBL219142::N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202086&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11495851 104081715 CHEMBL219142 ZINC36286181 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370483 C[C@H](N1CC[C@@H](F)C1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C17H27FN2O2/c1-10(20-3-2-14(18)9-20)16(21)19-15-12-4-11-5-13(15)8-17(22,6-11)7-12/h10-15,22H,2-9H2,1H3,(H,19,21)/t10-,11?,12?,13?,14+,15-,17-/m0/s1 ZFNDDTOHDPHZON-IXXSQMGDSA-N 50202106 CHEMBL218758::E-(2S)-(3R-fluoro-pyrrolidin-1-yl)-N-(5-hydroxy-adamantan-2-yl)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202106&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418852 104081735 CHEMBL218758 ZINC35087387 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370484 C[C@@H](N1CC[C@@H](F)C1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C17H27FN2O2/c1-10(20-3-2-14(18)9-20)16(21)19-15-12-4-11-5-13(15)8-17(22,6-11)7-12/h10-15,22H,2-9H2,1H3,(H,19,21)/t10-,11?,12?,13?,14-,15-,17-/m1/s1 ZFNDDTOHDPHZON-CRGRXCIBSA-N 50202095 CHEMBL415429::E-(2R)-(3R-fluoro-pyrrolidin-1-yl)-N-(5-hydroxy-adamantan-2-yl)-propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202095&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25210659 104081724 CHEMBL415429 ZINC35087385 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370492 CC(N1CCN(CC1)c1ccc(cn1)C(F)(F)F)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C23H31F3N4O2/c1-14(21(31)28-20-16-8-15-9-17(20)12-22(32,10-15)11-16)29-4-6-30(7-5-29)19-3-2-18(13-27-19)23(24,25)26/h2-3,13-17,20,32H,4-12H2,1H3,(H,28,31)/t14?,15?,16?,17?,20-,22- RSIROJJHJFVYIR-AZXBVUDKSA-N 50202102 CHEMBL375156::N-(5-Hydroxy-adamantan-2-yl)-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionamide::N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propionamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202102&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11676805 104081731 CHEMBL375156 ZINC35087408 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370496 CC(N1CC(C1)Oc1ccccc1F)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C22H29FN2O3/c1-13(25-11-17(12-25)28-19-5-3-2-4-18(19)23)21(26)24-20-15-6-14-7-16(20)10-22(27,8-14)9-15/h2-5,13-17,20,27H,6-12H2,1H3,(H,24,26)/t13?,14?,15?,16?,20-,22- XNSQYEZFDGACIR-CXAITDPASA-N 50202093 2-[3-(2-fluoro-phenoxy)-azetidin-1-yl]-N-(5-hydroxy-adamantan-2-yl)-propionamide::CHEMBL217917 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 56000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202093&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44418856 104081722 CHEMBL217917 ZINC35087396 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50370502 FC(F)(F)c1ccc(nc1)N1CCN(CC(=O)N[C@H]2C3CC4CC2C[C@](F)(C4)C3)CC1 InChI=1S/C22H28F4N4O/c23-21-9-14-7-15(10-21)20(16(8-14)11-21)28-19(31)13-29-3-5-30(6-4-29)18-2-1-17(12-27-18)22(24,25)26/h1-2,12,14-16,20H,3-11,13H2,(H,28,31)/t14?,15?,16?,20-,21- RUBWTVFAHWBQIP-VWPUDVFHSA-N 50202092 CHEMBL386029::N-[(E)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >20000 ChEMBL 10.1021/jm0609364 10.7270/Q2Z60NQN 17201418 Rohde, JJ; Pliushchev, MA; Sorensen, BK; Wodka, D; Shuai, Q; Wang, J; Fung, S; Monzon, KM; Chiou, WJ; Pan, L; Deng, X; Chovan, LE; Ramaiya, A; Mullally, M; Henry, RF; Stolarik, DF; Imade, HM; Marsh, KC; Beno, DW; Fey, TA; Droz, BA; Brune, ME; Camp, HS; Sham, HL; Frevert, EU; Jacobson, PB; Link, JT Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50202092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50202092&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11655097 104081721 CHEMBL386029 ZINC34630950 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50392059 CCC1(CC)OC(NC2CCCCCCC2)=NC1=O InChI=1S/C15H26N2O2/c1-3-15(4-2)13(18)17-14(19-15)16-12-10-8-6-5-7-9-11-12/h12H,3-11H2,1-2H3,(H,16,17,18) RCJPILQMNSKTFG-UHFFFAOYSA-N 50216917 2-(cyclooctylamino)-5,5-diethyloxazol-4(5H)-one::CHEMBL238187 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2007.06.054 10.7270/Q2MP52ZC 17600707 Sutin, L; Andersson, S; Bergquist, L; Castro, VM; Danielsson, E; James, S; Henriksson, M; Johansson, L; Kaiser, C; Flyren, K; Williams, M Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50216917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50216917&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44433347 104091181 CHEMBL238187 ZINC28824024 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50395304 CC(C)(NS(=O)(=O)c1ccccc1F)C(=O)N[C@H]1C2CC3CC1CC(C3)(C2)C(N)=O InChI=1S/C21H28FN3O4S/c1-20(2,25-30(28,29)16-6-4-3-5-15(16)22)19(27)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)26/h3-6,12-14,17,25H,7-11H2,1-2H3,(H2,23,26)(H,24,27)/t12?,13?,14?,17-,21? UBAPBKDXKUTATP-ZWRMXLCRSA-N 50112133 CHEMBL3609861::US9464044, 71 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10.0 ChEMBL 10.1016/j.bmcl.2015.06.099 10.7270/Q2BP04KW 26187704 Hong, SP; Nam, KY; Shin, YJ; Kim, KW; Ahn, SK Incheon National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112133&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 71511561 319493492 CHEMBL3609861 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50382916 COc1cc(ccc1C)C(=O)N1CCC(CC1)n1c2ccccc2[nH]c1=O InChI=1S/C21H23N3O3/c1-14-7-8-15(13-19(14)27-2)20(25)23-11-9-16(10-12-23)24-18-6-4-3-5-17(18)22-21(24)26/h3-8,13,16H,9-12H2,1-2H3,(H,22,26) WMRDDSTTZQYJLV-UHFFFAOYSA-N 50210884 1-(1-(3-methoxy-4-methylbenzoyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one::CHEMBL251402 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2007.03.083 10.7270/Q2GX4B72 17442567 Flyren, K; Bergquist, LO; Castro, VM; Fotsch, C; Johansson, L; St Jean, DJ; Sutin, L; Williams, M Biovitrum AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50210884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50210884&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44443435 104087204 CHEMBL251402 ZINC28955400 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413477 CCS(=O)(=O)c1ccccc1-c1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C27H25Cl2N3O2S/c1-3-35(33,34)24-8-5-4-7-21(24)18-9-14-22(23(29)17-18)25-30-31-26(32(25)2)27(15-6-16-27)19-10-12-20(28)13-11-19/h4-5,7-14,17H,3,6,15-16H2,1-2H3 CTTCBVOJARTTMW-UHFFFAOYSA-N 50261010 3-(3-Chloro-2'-ethanesulfonyl-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL496307 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261010&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576945 104110303 CHEMBL496307 ZINC49881749 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413478 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1ccc(cc1)S(C)(=O)=O InChI=1S/C26H23Cl2N3O2S/c1-31-24(29-30-25(31)26(14-3-15-26)19-7-9-20(27)10-8-19)22-13-6-18(16-23(22)28)17-4-11-21(12-5-17)34(2,32)33/h4-13,16H,3,14-15H2,1-2H3 MRTRRNXAPPQNFC-UHFFFAOYSA-N 50260937 3-(3-Chloro-4'-methanesulfonyl-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL497122 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260937&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576873 104110274 CHEMBL497122 ZINC40974088 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413479 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1cccc(c1)S(C)(=O)=O InChI=1S/C26H23Cl2N3O2S/c1-31-24(29-30-25(31)26(13-4-14-26)19-8-10-20(27)11-9-19)22-12-7-18(16-23(22)28)17-5-3-6-21(15-17)34(2,32)33/h3,5-12,15-16H,4,13-14H2,1-2H3 WMIKNIOIIKGHNU-UHFFFAOYSA-N 50260939 3-(3-Chloro-3'-methanesulfonyl-biphenyl-4-yl)-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL495889 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260939&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576875 104110276 CHEMBL495889 ZINC40954711 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413482 C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCn12 InChI=1S/C17H25N3/c1-2-4-15-18-19-16(20(15)5-3-1)17-9-12-6-13(10-17)8-14(7-12)11-17/h12-14H,1-11H2 VFTQRHWULYJKCI-UHFFFAOYSA-N 50239401 3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine::CHEMBL256777::MERCK-544 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3630776 104056507 CHEMBL256777 ZINC05494877 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413488 Clc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22ClN3/c19-15-9-7-14(8-10-15)18(11-5-12-18)17-21-20-16-6-3-1-2-4-13-22(16)17/h7-10H,1-6,11-13H2 FDLFGCPTRMXATH-UHFFFAOYSA-N 50239407 3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::3-[1-(4-Chloro-phenyl)-cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL257149 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239407&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10335880 104056508 CHEMBL257149 ZINC29044661 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413489 Cn1c(nnc1C12CC3CC(CC(C3)C1)C2)-c1ccccc1 InChI=1S/C19H23N3/c1-22-17(16-5-3-2-4-6-16)20-21-18(22)19-10-13-7-14(11-19)9-15(8-13)12-19/h2-6,13-15H,7-12H2,1H3 SPLKSRDVCTUAGF-UHFFFAOYSA-N 50239276 3-Adamantan-1-yl-4-methyl-5-phenyl-4H-[1,2,4]triazole::CHEMBL428429 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239276&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10193044 104056504 CHEMBL428429 ZINC13984397 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413590 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1nccs1 InChI=1S/C22H19ClN4S/c1-27-19(15-3-5-16(6-4-15)20-24-13-14-28-20)25-26-21(27)22(11-2-12-22)17-7-9-18(23)10-8-17/h3-10,13-14H,2,11-12H2,1H3 UVSPAWUXRFWMOR-UHFFFAOYSA-N 50260882 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(thiazol-2-yl)phenyl)-4H-1,2,4-triazole::CHEMBL494639 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260882&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576805 104110243 CHEMBL494639 ZINC40954219 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413591 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-n1cccc1 InChI=1S/C23H21ClN4/c1-27-21(17-5-11-20(12-6-17)28-15-2-3-16-28)25-26-22(27)23(13-4-14-23)18-7-9-19(24)10-8-18/h2-3,5-12,15-16H,4,13-14H2,1H3 JPLLVYRQKLXUGS-UHFFFAOYSA-N 50260881 3-(4-(1H-pyrrol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL524040 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260881&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576804 104110242 CHEMBL524040 ZINC40953931 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413592 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-n1ccnc1 InChI=1S/C22H20ClN5/c1-27-20(16-3-9-19(10-4-16)28-14-13-24-15-28)25-26-21(27)22(11-2-12-22)17-5-7-18(23)8-6-17/h3-10,13-15H,2,11-12H2,1H3 HYLCZNXUPJNYNR-UHFFFAOYSA-N 50260879 3-(4-(1H-imidazol-1-yl)phenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL494637 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260879&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576803 104110240 CHEMBL494637 ZINC40429768 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413593 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(Oc2ccccc2)cc1 InChI=1S/C25H22ClN3O/c1-29-23(18-8-14-22(15-9-18)30-21-6-3-2-4-7-21)27-28-24(29)25(16-5-17-25)19-10-12-20(26)13-11-19/h2-4,6-15H,5,16-17H2,1H3 NOBNEGOCMCJSIK-UHFFFAOYSA-N 50260878 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-phenoxyphenyl)-4H-1,2,4-triazole::CHEMBL493801 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260878&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576802 104110239 CHEMBL493801 ZINC40952909 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413594 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(C)(C)C InChI=1S/C23H26ClN3/c1-22(2,3)17-8-6-16(7-9-17)20-25-26-21(27(20)4)23(14-5-15-23)18-10-12-19(24)13-11-18/h6-13H,5,14-15H2,1-4H3 NYCVQZBNPJYEDN-UHFFFAOYSA-N 50260825 3-(4-tert-butylphenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL497558 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260825&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576752 104110233 CHEMBL497558 ZINC40973590 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413595 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(Cc2ccccc2)cc1 InChI=1S/C26H24ClN3/c1-30-24(21-10-8-20(9-11-21)18-19-6-3-2-4-7-19)28-29-25(30)26(16-5-17-26)22-12-14-23(27)15-13-22/h2-4,6-15H,5,16-18H2,1H3 UJHFTEDLBITHDN-UHFFFAOYSA-N 50260824 3-(4-benzylphenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL495691 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260824&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576751 104110232 CHEMBL495691 ZINC40429253 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413596 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccc(F)cc1 InChI=1S/C25H21ClFN3/c1-30-23(19-5-3-17(4-6-19)18-7-13-22(27)14-8-18)28-29-24(30)25(15-2-16-25)20-9-11-21(26)12-10-20/h3-14H,2,15-16H2,1H3 VCTHRPMMDKRYPK-UHFFFAOYSA-N 50260823 3-[1-(4-Chloro-phenyl)-cyclobutyl]-5-(4'-fluoro-biphenyl-4-yl)-4-methyl-4H-[1,2,4]triazole::CHEMBL495690 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260823&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576750 104110231 CHEMBL495690 ZINC40956730 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50402843 Oc1nc(Nc2ccccc2F)sc1C1CCCCC1 InChI=1S/C15H17FN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18) DHVHIYUQUBWXDJ-UHFFFAOYSA-N 50224202 5-cyclohexyl-2-(2-fluorophenylamino)thiazol-4(5H)-one::CHEMBL240053 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 530 ChEMBL 10.1016/j.bmcl.2007.09.070 10.7270/Q2X34X6D 17919905 Yuan, C; St Jean, DJ; Liu, Q; Cai, L; Li, A; Han, N; Moniz, G; Askew, B; Hungate, RW; Johansson, L; Tedenborg, L; Pyring, D; Williams, M; Hale, C; Chen, M; Cupples, R; Zhang, J; Jordan, S; Bartberger, MD; Sun, Y; Emery, M; Wang, M; Fotsch, C Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224202&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 91583863 104095926 CHEMBL240053 ZINC28826766 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413600 COc1ccc(cc1F)-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C20H19ClFN3O/c1-25-18(13-4-9-17(26-2)16(22)12-13)23-24-19(25)20(10-3-11-20)14-5-7-15(21)8-6-14/h4-9,12H,3,10-11H2,1-2H3 VMIACAXLJCXOQZ-UHFFFAOYSA-N 50260795 3-(1-(4-chlorophenyl)cyclobutyl)-5-(3-fluoro-4-methoxyphenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL496097 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260795&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10474399 104110215 CHEMBL496097 ZINC38933281 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413601 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(O)c(F)c1 InChI=1S/C19H17ClFN3O/c1-24-17(12-3-8-16(25)15(21)11-12)22-23-18(24)19(9-2-10-19)13-4-6-14(20)7-5-13/h3-8,11,25H,2,9-10H2,1H3 IHADCYYSVVNWIT-UHFFFAOYSA-N 50260794 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-2-fluorophenol::CHEMBL496096 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260794&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724919 104110214 CHEMBL496096 ZINC38824230 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413602 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl InChI=1S/C19H16Cl3N3/c1-25-17(15-8-7-14(21)11-16(15)22)23-24-18(25)19(9-2-10-19)12-3-5-13(20)6-4-12/h3-8,11H,2,9-10H2,1H3 WXIOFSFWRFRIPP-UHFFFAOYSA-N 50260793 3-(1-(4-chlorophenyl)cyclobutyl)-5-(2,4-dichlorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL496095 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260793&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724901 104110213 CHEMBL496095 ZINC40431152 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413603 COc1ccccc1-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C20H20ClN3O/c1-24-18(16-6-3-4-7-17(16)25-2)22-23-19(24)20(12-5-13-20)14-8-10-15(21)11-9-14/h3-4,6-11H,5,12-13H2,1-2H3 ZVHDYQKHKNEHDW-UHFFFAOYSA-N 50260749 3-(1-(4-chlorophenyl)cyclobutyl)-5-(2-methoxyphenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL525003 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260749&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10473292 104110183 CHEMBL525003 ZINC38930172 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413604 Cc1ccccc1-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C20H20ClN3/c1-14-6-3-4-7-17(14)18-22-23-19(24(18)2)20(12-5-13-20)15-8-10-16(21)11-9-15/h3-4,6-11H,5,12-13H2,1-2H3 BIRQMROLZMWVQO-UHFFFAOYSA-N 50260748 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-o-tolyl-4H-1,2,4-triazole::CHEMBL498352 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260748&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10315044 104110182 CHEMBL498352 ZINC38493463 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413605 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(I)cc1 InChI=1S/C19H17ClIN3/c1-24-17(13-3-9-16(21)10-4-13)22-23-18(24)19(11-2-12-19)14-5-7-15(20)8-6-14/h3-10H,2,11-12H2,1H3 CCIVUCGOJMDSLK-UHFFFAOYSA-N 50260747 3-(1-(4-chlorophenyl)cyclobutyl)-5-(4-iodophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL498351 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260747&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576672 104110181 CHEMBL498351 ZINC40424307 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413606 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1C(F)(F)F InChI=1S/C20H17ClF3N3/c1-27-17(15-5-2-3-6-16(15)20(22,23)24)25-26-18(27)19(11-4-12-19)13-7-9-14(21)10-8-13/h2-3,5-10H,4,11-12H2,1H3 UQVNBHWADMNPJM-UHFFFAOYSA-N 50260746 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL524824 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260746&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11741200 104110180 CHEMBL524824 ZINC36400453 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413607 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(F)(F)F InChI=1S/C20H17ClF3N3/c1-27-17(13-3-5-15(6-4-13)20(22,23)24)25-26-18(27)19(11-2-12-19)14-7-9-16(21)10-8-14/h3-10H,2,11-12H2,1H3 BTXMBHFNWIETNI-UHFFFAOYSA-N 50260745 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL498353 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260745&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724898 104110179 CHEMBL498353 ZINC40430352 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413608 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(F)c1 InChI=1S/C19H17ClFN3/c1-24-17(13-4-2-5-16(21)12-13)22-23-18(24)19(10-3-11-19)14-6-8-15(20)9-7-14/h2,4-9,12H,3,10-11H2,1H3 QIZUXQUFXCPBPX-UHFFFAOYSA-N 50260708 3-(1-(4-chlorophenyl)cyclobutyl)-5-(3-fluorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL496295 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260708&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724903 104110156 CHEMBL496295 ZINC40972933 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413609 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1F InChI=1S/C19H17ClFN3/c1-24-17(15-5-2-3-6-16(15)21)22-23-18(24)19(11-4-12-19)13-7-9-14(20)10-8-13/h2-3,5-10H,4,11-12H2,1H3 QWPFWVRPEFMTNO-UHFFFAOYSA-N 50260707 3-(1-(4-chlorophenyl)cyclobutyl)-5-(2-fluorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL496294 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260707&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10359991 104110155 CHEMBL496294 ZINC38617983 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413610 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(F)cc1 InChI=1S/C19H17ClFN3/c1-24-17(13-3-9-16(21)10-4-13)22-23-18(24)19(11-2-12-19)14-5-7-15(20)8-6-14/h3-10H,2,11-12H2,1H3 UYAYFLIYMDGFPR-UHFFFAOYSA-N 50260706 3-(1-(4-chlorophenyl)cyclobutyl)-5-(4-fluorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL508147 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260706&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576651 104110154 CHEMBL508147 ZINC40846272 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413611 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(Cl)c1 InChI=1S/C19H17Cl2N3/c1-24-17(13-4-2-5-16(21)12-13)22-23-18(24)19(10-3-11-19)14-6-8-15(20)9-7-14/h2,4-9,12H,3,10-11H2,1H3 NQHSJELQQVWZJD-UHFFFAOYSA-N 50260705 3-(3-chlorophenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL497951 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260705&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724912 104110153 CHEMBL497951 ZINC40424391 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413612 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1Cl InChI=1S/C19H17Cl2N3/c1-24-17(15-5-2-3-6-16(15)21)22-23-18(24)19(11-4-12-19)13-7-9-14(20)10-8-13/h2-3,5-10H,4,11-12H2,1H3 HSVNFDUPXHVBSA-UHFFFAOYSA-N 50260704 3-(2-chlorophenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL497748 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260704&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9998483 104110152 CHEMBL497748 ZINC03928058 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413613 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(Cl)cc1 InChI=1S/C19H17Cl2N3/c1-24-17(13-3-7-15(20)8-4-13)22-23-18(24)19(11-2-12-19)14-5-9-16(21)10-6-14/h3-10H,2,11-12H2,1H3 PWFIVVWXVGTAHD-UHFFFAOYSA-N 50260670 3-(4-chlorophenyl)-5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazole::CHEMBL494819 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260670&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9975639 104110137 CHEMBL494819 ZINC40430566 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413614 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(OC(F)(F)F)c1 InChI=1S/C20H17ClF3N3O/c1-27-17(13-4-2-5-16(12-13)28-20(22,23)24)25-26-18(27)19(10-3-11-19)14-6-8-15(21)9-7-14/h2,4-9,12H,3,10-11H2,1H3 HZCDXSQWAXTCAH-UHFFFAOYSA-N 50260669 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(3-(trifluoromethoxy)phenyl)-4H-1,2,4-triazole::CHEMBL525606 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260669&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576637 104110136 CHEMBL525606 ZINC40425311 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413615 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1OC(F)(F)F InChI=1S/C20H17ClF3N3O/c1-27-17(15-5-2-3-6-16(15)28-20(22,23)24)25-26-18(27)19(11-4-12-19)13-7-9-14(21)10-8-13/h2-3,5-10H,4,11-12H2,1H3 JGPTYPUUBLBVQQ-UHFFFAOYSA-N 50260668 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(2-(trifluoromethoxy)phenyl)-4H-1,2,4-triazole::CHEMBL494809 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260668&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10250842 104110135 CHEMBL494809 ZINC40955656 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413616 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(OC(F)(F)F)cc1 InChI=1S/C20H17ClF3N3O/c1-27-17(13-3-9-16(10-4-13)28-20(22,23)24)25-26-18(27)19(11-2-12-19)14-5-7-15(21)8-6-14/h3-10H,2,11-12H2,1H3 ORACBUKRQCFDKX-UHFFFAOYSA-N 50260667 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(trifluoromethoxy)phenyl)-4H-1,2,4-triazole::CHEMBL522533 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260667&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11742158 104110134 CHEMBL522533 ZINC36401412 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413617 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(O)c1 InChI=1S/C19H18ClN3O/c1-23-17(13-4-2-5-16(24)12-13)21-22-18(23)19(10-3-11-19)14-6-8-15(20)9-7-14/h2,4-9,12,24H,3,10-11H2,1H3 PIMSKOVVWSNBGX-UHFFFAOYSA-N 50260666 3-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenol::CHEMBL521688 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260666&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576636 104110133 CHEMBL521688 ZINC40954587 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413618 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1O InChI=1S/C19H18ClN3O/c1-23-17(15-5-2-3-6-16(15)24)21-22-18(23)19(11-4-12-19)13-7-9-14(20)10-8-13/h2-3,5-10,24H,4,11-12H2,1H3 RXQRMKXPLSFHNN-UHFFFAOYSA-N 50260625 2-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenol::CHEMBL494206 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260625&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10246599 104110115 CHEMBL494206 ZINC38421937 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413619 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(O)cc1 InChI=1S/C19H18ClN3O/c1-23-17(13-3-9-16(24)10-4-13)21-22-18(23)19(11-2-12-19)14-5-7-15(20)8-6-14/h3-10,24H,2,11-12H2,1H3 WTQKKLLPYZOULB-UHFFFAOYSA-N 50260624 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenol::CHEMBL494180 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260624&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724920 104110114 CHEMBL494180 ZINC40952632 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413620 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1 InChI=1S/C19H18ClN3/c1-23-17(14-6-3-2-4-7-14)21-22-18(23)19(12-5-13-19)15-8-10-16(20)11-9-15/h2-4,6-11H,5,12-13H2,1H3 AMRNFCHSNOKVDZ-UHFFFAOYSA-N 50260623 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-phenyl-4H-1,2,4-triazole::CHEMBL523177 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260623&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724899 104110113 CHEMBL523177 ZINC40425335 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413597 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1cccc(c1)-c1ccccc1 InChI=1S/C25H22ClN3/c1-29-23(20-10-5-9-19(17-20)18-7-3-2-4-8-18)27-28-24(29)25(15-6-16-25)21-11-13-22(26)14-12-21/h2-5,7-14,17H,6,15-16H2,1H3 FXLJWOWLNCXDCJ-UHFFFAOYSA-N 50260822 3-Biphenyl-3-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL525924 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260822&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576749 104110230 CHEMBL525924 ZINC40425303 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413598 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C25H22ClN3/c1-29-23(20-10-8-19(9-11-20)18-6-3-2-4-7-18)27-28-24(29)25(16-5-17-25)21-12-14-22(26)15-13-21/h2-4,6-15H,5,16-17H2,1H3 UXOKGMBZBAXMDM-UHFFFAOYSA-N 50260797 3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL525361 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260797&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10340916 104110217 CHEMBL525361 ZINC38558781 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50413599 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(OC2CC2)cc1 InChI=1S/C22H22ClN3O/c1-26-20(15-3-9-18(10-4-15)27-19-11-12-19)24-25-21(26)22(13-2-14-22)16-5-7-17(23)8-6-16/h3-10,19H,2,11-14H2,1H3 UPOIRNUSRYYGME-UHFFFAOYSA-N 50260796 3-(1-(4-chlorophenyl)cyclobutyl)-5-(4-cyclopropoxyphenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL497960 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.013 10.7270/Q2XP74QM 18440811 Zhu, Y; Olson, SH; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260796&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576707 104110216 CHEMBL497960 ZINC40425122 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50402882 CC(C)c1sc(Nc2ccccc2Cl)nc1O InChI=1S/C12H13ClN2OS/c1-7(2)10-11(16)15-12(17-10)14-9-6-4-3-5-8(9)13/h3-7,16H,1-2H3,(H,14,15) CGWOWWGIXZJYDE-UHFFFAOYSA-N 50224208 2-(2-chlorophenylamino)-5-isopropylthiazol-4(5H)-one::CHEMBL235762 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2510 ChEMBL 10.1016/j.bmcl.2007.09.070 10.7270/Q2X34X6D 17919905 Yuan, C; St Jean, DJ; Liu, Q; Cai, L; Li, A; Han, N; Moniz, G; Askew, B; Hungate, RW; Johansson, L; Tedenborg, L; Pyring, D; Williams, M; Hale, C; Chen, M; Cupples, R; Zhang, J; Jordan, S; Bartberger, MD; Sun, Y; Emery, M; Wang, M; Fotsch, C Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224208&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 91043641 104095932 CHEMBL235762 ZINC28826724 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50402885 Oc1nc(Nc2ccccc2F)sc1C1CCCC1 InChI=1S/C14H15FN2OS/c15-10-7-3-4-8-11(10)16-14-17-13(18)12(19-14)9-5-1-2-6-9/h3-4,7-9,18H,1-2,5-6H2,(H,16,17) YHZJXPZWKDRZOT-UHFFFAOYSA-N 50224221 5-cyclopentyl-2-(2-fluorophenylamino)thiazol-4(5H)-one::CHEMBL240269 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 380 ChEMBL 10.1016/j.bmcl.2007.09.070 10.7270/Q2X34X6D 17919905 Yuan, C; St Jean, DJ; Liu, Q; Cai, L; Li, A; Han, N; Moniz, G; Askew, B; Hungate, RW; Johansson, L; Tedenborg, L; Pyring, D; Williams, M; Hale, C; Chen, M; Cupples, R; Zhang, J; Jordan, S; Bartberger, MD; Sun, Y; Emery, M; Wang, M; Fotsch, C Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224221&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 91201421 104095945 CHEMBL240269 ZINC28826767 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50402886 Oc1nc(Nc2ccccc2Cl)sc1C1CCCC1 InChI=1S/C14H15ClN2OS/c15-10-7-3-4-8-11(10)16-14-17-13(18)12(19-14)9-5-1-2-6-9/h3-4,7-9,18H,1-2,5-6H2,(H,16,17) VUZTZCDPUJJXMS-UHFFFAOYSA-N 50224216 2-(2-chlorophenylamino)-5-cyclopentylthiazol-4(5H)-one::CHEMBL240052 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 4500 ChEMBL 10.1016/j.bmcl.2007.09.070 10.7270/Q2X34X6D 17919905 Yuan, C; St Jean, DJ; Liu, Q; Cai, L; Li, A; Han, N; Moniz, G; Askew, B; Hungate, RW; Johansson, L; Tedenborg, L; Pyring, D; Williams, M; Hale, C; Chen, M; Cupples, R; Zhang, J; Jordan, S; Bartberger, MD; Sun, Y; Emery, M; Wang, M; Fotsch, C Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224216&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 91049393 104095940 CHEMBL240052 ZINC28826764 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50402888 Oc1nc(Nc2ccccc2Cl)sc1C1CCCCC1 InChI=1S/C15H17ClN2OS/c16-11-8-4-5-9-12(11)17-15-18-14(19)13(20-15)10-6-2-1-3-7-10/h4-5,8-10,19H,1-3,6-7H2,(H,17,18) SIHMARIGLPGOTP-UHFFFAOYSA-N 50224203 2-(2-chlorophenylamino)-5-cyclohexylthiazol-4(5H)-one::CHEMBL240039 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 4600 ChEMBL 10.1016/j.bmcl.2007.09.070 10.7270/Q2X34X6D 17919905 Yuan, C; St Jean, DJ; Liu, Q; Cai, L; Li, A; Han, N; Moniz, G; Askew, B; Hungate, RW; Johansson, L; Tedenborg, L; Pyring, D; Williams, M; Hale, C; Chen, M; Cupples, R; Zhang, J; Jordan, S; Bartberger, MD; Sun, Y; Emery, M; Wang, M; Fotsch, C Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224203&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 91173967 104095927 CHEMBL240039 ZINC28826763 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50442448 C[C@H](NC1=NC(=O)C(C)(S1)C(C)(C)O)c1ccc(F)cc1 InChI=1S/C15H19FN2O2S/c1-9(10-5-7-11(16)8-6-10)17-13-18-12(19)15(4,21-13)14(2,3)20/h5-9,20H,1-4H3,(H,17,18,19)/t9-,15?/m0/s1 HYVZYASDRIAOPU-HJULIUOESA-N 50273857 2-((S)-1-(4-fluorophenyl)ethylamino)-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one::CHEMBL461879 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm801073z 10.7270/Q2FJ2GN7 19053753 Fotsch, C; Bartberger, MD; Bercot, EA; Chen, M; Cupples, R; Emery, M; Fretland, J; Guram, A; Hale, C; Han, N; Hickman, D; Hungate, RW; Hayashi, M; Komorowski, R; Liu, Q; Matsumoto, G; St Jean, DJ; Ursu, S; Veniant, M; Xu, G; Ye, Q; Yuan, C; Zhang, J; Zhang, X; Tu, H; Wang, M Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273857&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44588423 104117845 CHEMBL461879 ZINC40848960 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50442449 C[C@H](NC1=NC(=O)C(C)(S1)C1(O)CCCC1)c1ccc(F)cc1 InChI=1S/C17H21FN2O2S/c1-11(12-5-7-13(18)8-6-12)19-15-20-14(21)16(2,23-15)17(22)9-3-4-10-17/h5-8,11,22H,3-4,9-10H2,1-2H3,(H,19,20,21)/t11-,16?/m0/s1 WWOQHILNLFODCY-CHPOKUKFSA-N 50273859 2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxycyclopentyl)-5-methylthiazol-4(5H)-one::CHEMBL517874 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm801073z 10.7270/Q2FJ2GN7 19053753 Fotsch, C; Bartberger, MD; Bercot, EA; Chen, M; Cupples, R; Emery, M; Fretland, J; Guram, A; Hale, C; Han, N; Hickman, D; Hungate, RW; Hayashi, M; Komorowski, R; Liu, Q; Matsumoto, G; St Jean, DJ; Ursu, S; Veniant, M; Xu, G; Ye, Q; Yuan, C; Zhang, J; Zhang, X; Tu, H; Wang, M Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273859&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 16737758 104117847 CHEMBL517874 ZINC40863453 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50442450 C[C@H](NC1=NC(=O)C(C)(S1)C1(O)CCC1)c1ccc(F)cc1 InChI=1S/C16H19FN2O2S/c1-10(11-4-6-12(17)7-5-11)18-14-19-13(20)15(2,22-14)16(21)8-3-9-16/h4-7,10,21H,3,8-9H2,1-2H3,(H,18,19,20)/t10-,15?/m0/s1 ITBTWAJBZMDXOD-MYHCZTBNSA-N 50273858 2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(1-hydroxycyclobutyl)-5-methylthiazol-4(5H)-one::CHEMBL460393 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm801073z 10.7270/Q2FJ2GN7 19053753 Fotsch, C; Bartberger, MD; Bercot, EA; Chen, M; Cupples, R; Emery, M; Fretland, J; Guram, A; Hale, C; Han, N; Hickman, D; Hungate, RW; Hayashi, M; Komorowski, R; Liu, Q; Matsumoto, G; St Jean, DJ; Ursu, S; Veniant, M; Xu, G; Ye, Q; Yuan, C; Zhang, J; Zhang, X; Tu, H; Wang, M Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273858&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 16736282 104117846 CHEMBL460393 ZINC40392297 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50442451 C[C@H](NC1=NC(=O)C(C)(S1)C(C)(C)O)c1ccccc1C(F)(F)F InChI=1S/C16H19F3N2O2S/c1-9(10-7-5-6-8-11(10)16(17,18)19)20-13-21-12(22)15(4,24-13)14(2,3)23/h5-9,23H,1-4H3,(H,20,21,22)/t9-,15?/m0/s1 ZOWSXPJLDABSMI-HJULIUOESA-N 50273456 (S)-5-(2-Hydroxypropan-2-yl)-5-methyl-2-{1-[2-(trifluoromethyl)-phenyl]ethylamino}thiazol-4(5H)-one::CHEMBL456538 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm801073z 10.7270/Q2FJ2GN7 19053753 Fotsch, C; Bartberger, MD; Bercot, EA; Chen, M; Cupples, R; Emery, M; Fretland, J; Guram, A; Hale, C; Han, N; Hickman, D; Hungate, RW; Hayashi, M; Komorowski, R; Liu, Q; Matsumoto, G; St Jean, DJ; Ursu, S; Veniant, M; Xu, G; Ye, Q; Yuan, C; Zhang, J; Zhang, X; Tu, H; Wang, M Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273456&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25179899 104117582 CHEMBL456538 ZINC40848958 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50442452 C[C@H](NC1=NC(=O)C(C)(S1)C(C)(C)O)c1ccccc1Cl InChI=1S/C15H19ClN2O2S/c1-9(10-7-5-6-8-11(10)16)17-13-18-12(19)15(4,21-13)14(2,3)20/h5-9,20H,1-4H3,(H,17,18,19)/t9-,15?/m0/s1 SAFBQFCXQCUPQN-HJULIUOESA-N 50273455 2-[(S)-1-(2-Chlorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one::CHEMBL512907 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm801073z 10.7270/Q2FJ2GN7 19053753 Fotsch, C; Bartberger, MD; Bercot, EA; Chen, M; Cupples, R; Emery, M; Fretland, J; Guram, A; Hale, C; Han, N; Hickman, D; Hungate, RW; Hayashi, M; Komorowski, R; Liu, Q; Matsumoto, G; St Jean, DJ; Ursu, S; Veniant, M; Xu, G; Ye, Q; Yuan, C; Zhang, J; Zhang, X; Tu, H; Wang, M Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273455&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 16737144 104117581 CHEMBL512907 ZINC40848955 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50442453 C[C@H](NC1=NC(=O)C(C)(S1)C(C)(C)O)c1ccccc1F InChI=1S/C15H19FN2O2S/c1-9(10-7-5-6-8-11(10)16)17-13-18-12(19)15(4,21-13)14(2,3)20/h5-9,20H,1-4H3,(H,17,18,19)/t9-,15?/m0/s1 ZSRUMWXDCGNNPN-HJULIUOESA-N 50273454 2-[(S)-1-(2-Fluorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one::CHEMBL456537 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm801073z 10.7270/Q2FJ2GN7 19053753 Fotsch, C; Bartberger, MD; Bercot, EA; Chen, M; Cupples, R; Emery, M; Fretland, J; Guram, A; Hale, C; Han, N; Hickman, D; Hungate, RW; Hayashi, M; Komorowski, R; Liu, Q; Matsumoto, G; St Jean, DJ; Ursu, S; Veniant, M; Xu, G; Ye, Q; Yuan, C; Zhang, J; Zhang, X; Tu, H; Wang, M Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273454&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25179898 104117580 CHEMBL456537 ZINC40848673 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50448563 C[C@@H]1CN(CC2(CC2)C(N)=O)CCN1S(=O)(=O)c1ccc(cc1)[C@](C)(O)C(F)(F)F InChI=1S/C19H26F3N3O4S/c1-13-11-24(12-18(7-8-18)16(23)26)9-10-25(13)30(28,29)15-5-3-14(4-6-15)17(2,27)19(20,21)22/h3-6,13,27H,7-12H2,1-2H3,(H2,23,26)/t13-,17+/m1/s1 YJFULAYRAKPBCY-DYVFJYSZSA-N 50248569 (1-(((R)-3-methyl-4-(4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)-piperazin-1-yl)methyl)-cyclopropanecarboxamide)::1-(((R)-3-methyl-4-(4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)phenylsulfonyl)piperazin-1-yl)methyl)cyclopropanecarboxamide::1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide::CHEMBL460962 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2008.12.114 10.7270/Q2QC03BN 19181519 Sun, D; Wang, Z; Cardozo, M; Choi, R; Degraffenreid, M; Di, Y; He, X; Jaen, JC; Labelle, M; Liu, J; Ma, J; Miao, S; Sudom, A; Tang, L; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50248569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50248569&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search D4N 24856362 104103207 CHEMBL460962 DB07624 ZINC39110046 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464852 CC(C)C1=CC[C@H](CS(=O)(=O)c2nc3ccccc3s2)[C@]11CCC(=O)C=C1 InChI=1S/C21H23NO3S2/c1-14(2)17-8-7-15(21(17)11-9-16(23)10-12-21)13-27(24,25)20-22-18-5-3-4-6-19(18)26-20/h3-6,8-9,11,14-15H,7,10,12-13H2,1-2H3/t15-,21+/m1/s1 AZIFAEZORSWDIZ-VFNWGFHPSA-N 50145433 CHEMBL3764356 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145433&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011476 85428481 CHEMBL3764356 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464853 CC(C)C1=CC[C@H](CS(=O)(=O)c2nc3ccccc3o2)[C@]11CCC(=O)C=C1 InChI=1S/C21H23NO4S/c1-14(2)17-8-7-15(21(17)11-9-16(23)10-12-21)13-27(24,25)20-22-18-5-3-4-6-19(18)26-20/h3-6,8-9,11,14-15H,7,10,12-13H2,1-2H3/t15-,21+/m1/s1 UDJGASNQOSBFLY-VFNWGFHPSA-N 50145434 CHEMBL3763513 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145434&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011470 85428480 CHEMBL3763513 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464857 CC(C)C1=CC[C@H](CS(=O)(=O)c2ccc3ccccc3c2)[C@]11CCC(=O)C=C1 InChI=1S/C24H26O3S/c1-17(2)23-10-8-20(24(23)13-11-21(25)12-14-24)16-28(26,27)22-9-7-18-5-3-4-6-19(18)15-22/h3-7,9-11,13,15,17,20H,8,12,14,16H2,1-2H3/t20-,24+/m1/s1 PUJMQAPTJYSHAS-YKSBVNFPSA-N 50145438 CHEMBL3764124 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145438&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011483 85428338 CHEMBL3764124 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464862 CC(C)C1=CC[C@H](C(=O)Nc2ncc(s2)-c2ccc(Cl)cc2)[C@]11CCC(=O)C=C1 InChI=1S/C23H23ClN2O2S/c1-14(2)18-7-8-19(23(18)11-9-17(27)10-12-23)21(28)26-22-25-13-20(29-22)15-3-5-16(24)6-4-15/h3-7,9,11,13-14,19H,8,10,12H2,1-2H3,(H,25,26,28)/t19-,23-/m1/s1 ZKOSXJPBSUPTOB-AUSIDOKSSA-N 50145439 CHEMBL3764221 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145439&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011482 85428378 CHEMBL3764221 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464867 CC(C)C1=CC[C@H](C(=O)NCCc2cccs2)[C@]11CCC(=O)C=C1 InChI=1S/C20H25NO2S/c1-14(2)17-5-6-18(20(17)10-7-15(22)8-11-20)19(23)21-12-9-16-4-3-13-24-16/h3-5,7,10,13-14,18H,6,8-9,11-12H2,1-2H3,(H,21,23)/t18-,20-/m1/s1 GEZNXYILQHUDNW-UYAOXDASSA-N 50145440 CHEMBL3765590 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145440&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011490 85428078 CHEMBL3765590 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464868 CC(C)C1=CC[C@H](C(=O)NCc2cc(F)cc(F)c2)[C@]11CCC(=O)C=C1 InChI=1S/C21H23F2NO2/c1-13(2)18-3-4-19(21(18)7-5-17(25)6-8-21)20(26)24-12-14-9-15(22)11-16(23)10-14/h3,5,7,9-11,13,19H,4,6,8,12H2,1-2H3,(H,24,26)/t19-,21-/m1/s1 DEQFLNYLNGXVDV-TZIWHRDSSA-N 50145441 CHEMBL3765258 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145441&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011477 85428893 CHEMBL3765258 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464869 CC(C)C1=CC[C@H](C(=O)NC(C)C23CC4CC(CC(C4)C2)C3)[C@]11CCC(=O)C=C1 InChI=1S/C26H37NO2/c1-16(2)22-4-5-23(26(22)8-6-21(28)7-9-26)24(29)27-17(3)25-13-18-10-19(14-25)12-20(11-18)15-25/h4,6,8,16-20,23H,5,7,9-15H2,1-3H3,(H,27,29)/t17?,18?,19?,20?,23-,25?,26-/m1/s1 QURCSFCXEGGZOP-ZTWQVIIFSA-N 50145442 CHEMBL3765140 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145442&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011485 85428140 CHEMBL3765140 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464874 CC(C)C1=CC[C@H](C(=O)NCC2CCC3CC2C3(C)C)[C@]11CCC(=O)C=C1 InChI=1S/C24H35NO2/c1-15(2)19-7-8-20(24(19)11-9-18(26)10-12-24)22(27)25-14-16-5-6-17-13-21(16)23(17,3)4/h7,9,11,15-17,20-21H,5-6,8,10,12-14H2,1-4H3,(H,25,27)/t16?,17?,20-,21?,24-/m1/s1 UJXOMZLXTJJELJ-CLHTUNCFSA-N 50145443 CHEMBL3765321 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145443&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011488 85428120 CHEMBL3765321 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464877 CC(C)C1=CC[C@H](C(=O)NC\C=C(/C)CCC=C(C)C)[C@]11CCC(=O)C=C1 InChI=1S/C24H35NO2/c1-17(2)7-6-8-19(5)13-16-25-23(27)22-10-9-21(18(3)4)24(22)14-11-20(26)12-15-24/h7,9,11,13-14,18,22H,6,8,10,12,15-16H2,1-5H3,(H,25,27)/b19-13+/t22-,24-/m1/s1 IOPSEJYEJPMCSD-DVJXQAEMSA-N 50145444 CHEMBL3763187 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145444&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011473 85428302 CHEMBL3763187 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464879 CC(C)C1=CC[C@H](CSc2nc3ccccc3s2)[C@]11CCC(=O)C=C1 InChI=1S/C21H23NOS2/c1-14(2)17-8-7-15(21(17)11-9-16(23)10-12-21)13-24-20-22-18-5-3-4-6-19(18)25-20/h3-6,8-9,11,14-15H,7,10,12-13H2,1-2H3/t15-,21+/m1/s1 CKGNZJWBYYMRFO-VFNWGFHPSA-N 50145445 CHEMBL3764012 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145445&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011479 85428924 CHEMBL3764012 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464881 CC(C)C1=CC[C@H](CSc2nc3ccccc3o2)[C@]11CCC(=O)C=C1 InChI=1S/C21H23NO2S/c1-14(2)17-8-7-15(21(17)11-9-16(23)10-12-21)13-25-20-22-18-5-3-4-6-19(18)24-20/h3-6,8-9,11,14-15H,7,10,12-13H2,1-2H3/t15-,21+/m1/s1 KFBDTDXSQNSGEL-VFNWGFHPSA-N 50145446 CHEMBL3765604 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145446&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 1097735 85428922 CHEMBL3765604 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464882 CCCCCCSc1nnc(SC[C@H]2CC=C(C(C)C)[C@@]22CCC(=O)C=C2)s1 InChI=1S/C22H32N2OS3/c1-4-5-6-7-14-26-20-23-24-21(28-20)27-15-17-8-9-19(16(2)3)22(17)12-10-18(25)11-13-22/h9-10,12,16-17H,4-8,11,13-15H2,1-3H3/t17-,22+/m1/s1 ATSKIWLTBBPTFN-VGSWGCGISA-N 50145447 CHEMBL3764965 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145447&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011474 85428056 CHEMBL3764965 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464883 CCn1c2ccccc2c2nnc(SC[C@H]3CC=C(C(C)C)[C@@]33CCC(=O)C=C3)nc12 InChI=1S/C25H28N4OS/c1-4-29-21-8-6-5-7-19(21)22-23(29)26-24(28-27-22)31-15-17-9-10-20(16(2)3)25(17)13-11-18(30)12-14-25/h5-8,10-11,13,16-17H,4,9,12,14-15H2,1-3H3/t17-,25+/m1/s1 OKVSRPCETYJNQX-NSYGIPOTSA-N 50145448 CHEMBL3764520 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145448&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011480 85428341 CHEMBL3764520 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464888 CC(C)C1=CC[C@H](CSc2nnnn2-c2ccccc2)[C@]11CCC(=O)C=C1 InChI=1S/C21H24N4OS/c1-15(2)19-9-8-16(21(19)12-10-18(26)11-13-21)14-27-20-22-23-24-25(20)17-6-4-3-5-7-17/h3-7,9-10,12,15-16H,8,11,13-14H2,1-2H3/t16-,21+/m1/s1 XJXOCDGNQFHCDT-IERDGZPVSA-N 50145449 CHEMBL3764025 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145449&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011469 85428514 CHEMBL3764025 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464894 CC(C)C1=CC[C@H](CSc2ccc3ccccc3c2)[C@]11CCC(=O)C=C1 InChI=1S/C24H26OS/c1-17(2)23-10-8-20(24(23)13-11-21(25)12-14-24)16-26-22-9-7-18-5-3-4-6-19(18)15-22/h3-7,9-11,13,15,17,20H,8,12,14,16H2,1-2H3/t20-,24+/m1/s1 UFAQIOAUYBNIFT-YKSBVNFPSA-N 50145450 CHEMBL3764111 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145450&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011489 85428119 CHEMBL3764111 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464895 CC(C)C1=CC[C@H](Cn2cc(CN(c3ncccn3)S(=O)(=O)c3ccc(N)cc3)nn2)[C@]11CCC(=O)C=C1 InChI=1S/C27H31N7O3S/c1-19(2)25-9-4-20(27(25)12-10-23(35)11-13-27)16-33-17-22(31-32-33)18-34(26-29-14-3-15-30-26)38(36,37)24-7-5-21(28)6-8-24/h3,5-10,12,14-15,17,19-20H,4,11,13,16,18,28H2,1-2H3/t20-,27+/m1/s1 JNYLDCDQEZYRJA-HRFSGMKKSA-N 50145428 CHEMBL3764299 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145428&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011478 85428925 CHEMBL3764299 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464897 CC(C)C1=CC[C@H](CN2C(=O)c3ccccc3S2(=O)=O)[C@]11CCC(=O)C=C1 InChI=1S/C21H23NO4S/c1-14(2)18-8-7-15(21(18)11-9-16(23)10-12-21)13-22-20(24)17-5-3-4-6-19(17)27(22,25)26/h3-6,8-9,11,14-15H,7,10,12-13H2,1-2H3/t15-,21+/m1/s1 WVMMLQWXDKSHIG-VFNWGFHPSA-N 50145429 CHEMBL3763599 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145429&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011475 85428203 CHEMBL3763599 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464898 CC(C)C1=CC[C@H](CN2C(=O)c3ccccc3C2=O)[C@]11CCC(=O)C=C1 InChI=1S/C22H23NO3/c1-14(2)19-8-7-15(22(19)11-9-16(24)10-12-22)13-23-20(25)17-5-3-4-6-18(17)21(23)26/h3-6,8-9,11,14-15H,7,10,12-13H2,1-2H3/t15-,22+/m1/s1 YBTLLEPCHBGRAK-QRQCRPRQSA-N 50145430 CHEMBL3765656 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145430&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011471 85428510 CHEMBL3765656 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464901 CC(C)C1=CC[C@H](Cn2cc(CNC(=O)OC(C)(C)C)nn2)[C@]11CCC(=O)C=C1 InChI=1S/C22H32N4O3/c1-15(2)19-7-6-16(22(19)10-8-18(27)9-11-22)13-26-14-17(24-25-26)12-23-20(28)29-21(3,4)5/h7-8,10,14-16H,6,9,11-13H2,1-5H3,(H,23,28)/t16-,22+/m1/s1 LWRBSMYYLXHHFD-ZHRRBRCNSA-N 50145431 CHEMBL3764151 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145431&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011481 85428379 CHEMBL3764151 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464902 COc1ccc(cc1)S(=O)(=O)NCc1cn(C[C@H]2CC=C(C(C)C)[C@@]22CCC(=O)C=C2)nn1 InChI=1S/C24H30N4O4S/c1-17(2)23-9-4-18(24(23)12-10-20(29)11-13-24)15-28-16-19(26-27-28)14-25-33(30,31)22-7-5-21(32-3)6-8-22/h5-10,12,16-18,25H,4,11,13-15H2,1-3H3/t18-,24+/m1/s1 FPEBEYJKVPVBKT-KOSHJBKYSA-N 50145432 CHEMBL3764563 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145432&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011486 85428103 CHEMBL3764563 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464854 CCCCCCSc1nnc(s1)S(=O)(=O)C[C@H]1CC=C(C(C)C)[C@@]11CCC(=O)C=C1 InChI=1S/C22H32N2O3S3/c1-4-5-6-7-14-28-20-23-24-21(29-20)30(26,27)15-17-8-9-19(16(2)3)22(17)12-10-18(25)11-13-22/h9-10,12,16-17H,4-8,11,13-15H2,1-3H3/t17-,22+/m1/s1 MUFRAAXZUWIBPZ-VGSWGCGISA-N 50145435 CHEMBL3765510 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145435&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011472 85428512 CHEMBL3765510 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464855 CCn1c2ccccc2c2nnc(nc12)S(=O)(=O)C[C@H]1CC=C(C(C)C)[C@@]11CCC(=O)C=C1 InChI=1S/C25H28N4O3S/c1-4-29-21-8-6-5-7-19(21)22-23(29)26-24(28-27-22)33(31,32)15-17-9-10-20(16(2)3)25(17)13-11-18(30)12-14-25/h5-8,10-11,13,16-17H,4,9,12,14-15H2,1-3H3/t17-,25+/m1/s1 RKGQHJZGORQTQB-NSYGIPOTSA-N 50145436 CHEMBL3763512 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145436&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3011487 85428047 CHEMBL3763512 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50464856 CC(C)C1=CC[C@H](CS(=O)(=O)c2nnnn2-c2ccccc2)[C@]11CCC(=O)C=C1 InChI=1S/C21H24N4O3S/c1-15(2)19-9-8-16(21(19)12-10-18(26)11-13-21)14-29(27,28)20-22-23-24-25(20)17-6-4-3-5-7-17/h3-7,9-10,12,15-16H,8,11,13-14H2,1-2H3/t16-,21+/m1/s1 PTKWYDOYOPYBTE-IERDGZPVSA-N 50145437 CHEMBL3763813 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2016.01.027 10.7270/Q28P62DG 26820555 Ling, T; Gautam, LN; Griffith, E; Das, S; Lang, W; Shadrick, WR; Shelat, A; Lee, R; Rivas, F St. Jude Children's Research Hospital http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50145437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50145437&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44318549 85428143 CHEMBL3763813 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50509804 CC(C)(CC(=O)NC1CC1)CC(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C20H32N2O3/c1-19(2,10-16(23)21-15-3-4-15)11-17(24)22-18-13-5-12-6-14(18)9-20(25,7-12)8-13/h12-15,18,25H,3-11H2,1-2H3,(H,21,23)(H,22,24)/t12?,13?,14?,18-,20- ZQTYSHNSWFSRTJ-MMSAGYDNSA-N 50294764 3,3-Dimethyl-pentanedioic acid cyclopropylamide(5-hydroxy-adamantan-2-yl)-amide::CHEMBL550424 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.140 10.7270/Q2JQ112H 19395260 Roche, D; Carniato, D; Leriche, C; Lepifre, F; Christmann-Franck, S; Graedler, U; Charon, C; Bozec, S; Doare, L; Schmidlin, F; Lecomte, M; Valeur, E Merck Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294764&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24948172 104136295 CHEMBL550424 ZINC43017717 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50509832 CC(C)(CC(=O)NC1CC1)CC(=O)N[C@H]1C2CC3CC1C[C@](C3)(C2)C(N)=O InChI=1S/C21H33N3O3/c1-20(2,10-16(25)23-15-3-4-15)11-17(26)24-18-13-5-12-6-14(18)9-21(7-12,8-13)19(22)27/h12-15,18H,3-11H2,1-2H3,(H2,22,27)(H,23,25)(H,24,26)/t12?,13?,14?,18-,21- VLDUQTLOJSSOIR-RXAJHBGNSA-N 50294783 3,3-Dimethyl-pentanedioic acid(5-carbamoyl-adamantan-2-yl)-amide cyclopropylamide::CHEMBL563234 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.03.140 10.7270/Q2JQ112H 19395260 Roche, D; Carniato, D; Leriche, C; Lepifre, F; Christmann-Franck, S; Graedler, U; Charon, C; Bozec, S; Doare, L; Schmidlin, F; Lecomte, M; Valeur, E Merck Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294783&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45272366 104136314 CHEMBL563234 ZINC56834520 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549161 OC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2ccccc12 InChI=1S/C26H34N2O3/c29-23(30)14-20-15-26(22-4-2-1-3-21(20)22)5-7-28(8-6-26)25(31)27-24-18-10-16-9-17(12-18)13-19(24)11-16/h1-4,16-20,24H,5-15H2,(H,27,31)(H,29,30) GMKSWUJYABRINI-UHFFFAOYSA-N 50306421 2-{1'-[(adamantan-2-yl)carbamoyl]-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL598675 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306421&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24744047 104160782 CHEMBL598675 ZINC43194207 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549162 OC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2ccccc12 InChI=1S/C26H34N2O3/c29-23(30)14-20-15-26(22-4-2-1-3-21(20)22)5-7-28(8-6-26)25(31)27-24-18-10-16-9-17(12-18)13-19(24)11-16/h1-4,16-20,24H,5-15H2,(H,27,31)(H,29,30) GMKSWUJYABRINI-UHFFFAOYSA-N 50306421 2-{1'-[(adamantan-2-yl)carbamoyl]-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL598675 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 5900 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306421&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24744047 104160782 CHEMBL598675 ZINC43194207 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549163 OC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2ccccc12 InChI=1S/C26H34N2O3/c29-23(30)14-20-15-26(22-4-2-1-3-21(20)22)5-7-28(8-6-26)25(31)27-24-18-10-16-9-17(12-18)13-19(24)11-16/h1-4,16-20,24H,5-15H2,(H,27,31)(H,29,30) GMKSWUJYABRINI-UHFFFAOYSA-N 50306421 2-{1'-[(adamantan-2-yl)carbamoyl]-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL598675 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 5900 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306421&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24744047 104160782 CHEMBL598675 ZINC43194207 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549164 Cc1cccc2c1C(CC(O)=O)CC21CCN(CC1)C(=O)NC1C2CC3CC(C2)CC1C3 InChI=1S/C27H36N2O3/c1-16-3-2-4-22-24(16)21(14-23(30)31)15-27(22)5-7-29(8-6-27)26(32)28-25-19-10-17-9-18(12-19)13-20(25)11-17/h2-4,17-21,25H,5-15H2,1H3,(H,28,32)(H,30,31) RQGFSTVIFKBKGN-UHFFFAOYSA-N 50306422 2-{1'-[(adamantan-2-yl)carbamoyl]-4-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL597063 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 510 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306422&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25065025 104160783 CHEMBL597063 ZINC45357782 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549165 Cc1ccc2c(c1)C(CC(O)=O)CC21CCN(CC1)C(=O)NC1C2CC3CC(C2)CC1C3 InChI=1S/C27H36N2O3/c1-16-2-3-23-22(8-16)21(14-24(30)31)15-27(23)4-6-29(7-5-27)26(32)28-25-19-10-17-9-18(12-19)13-20(25)11-17/h2-3,8,17-21,25H,4-7,9-15H2,1H3,(H,28,32)(H,30,31) NNJVHRDAROUEEZ-UHFFFAOYSA-N 50306423 2-{1'-[(adamantan-2-yl)carbamoyl]-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL597481 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 10 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306423&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25065232 104160784 CHEMBL597481 ZINC45357855 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549166 Cc1ccc2C(CC(O)=O)CC3(CCN(CC3)C(=O)NC3C4CC5CC(C4)CC3C5)c2c1 InChI=1S/C27H36N2O3/c1-16-2-3-22-21(14-24(30)31)15-27(23(22)8-16)4-6-29(7-5-27)26(32)28-25-19-10-17-9-18(12-19)13-20(25)11-17/h2-3,8,17-21,25H,4-7,9-15H2,1H3,(H,28,32)(H,30,31) QXZBMZCHBSRYEQ-UHFFFAOYSA-N 50306424 2-{1'-[(adamantan-2-yl)carbamoyl]-6-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL597676 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306424&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25065231 104160785 CHEMBL597676 ZINC45358606 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549167 Cc1cccc2C(CC(O)=O)CC3(CCN(CC3)C(=O)NC3C4CC5CC(C4)CC3C5)c12 InChI=1S/C27H36N2O3/c1-16-3-2-4-22-21(14-23(30)31)15-27(24(16)22)5-7-29(8-6-27)26(32)28-25-19-10-17-9-18(12-19)13-20(25)11-17/h2-4,17-21,25H,5-15H2,1H3,(H,28,32)(H,30,31) LYHDMCHAMJFTNL-UHFFFAOYSA-N 50306425 2-{1'-[(adamantan-2-yl)carbamoyl]-7-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL605756 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306425&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25065024 104160786 CHEMBL605756 ZINC45387668 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549168 OC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2ccc(Cl)cc12 InChI=1S/C26H33ClN2O3/c27-20-1-2-22-21(13-20)19(12-23(30)31)14-26(22)3-5-29(6-4-26)25(32)28-24-17-8-15-7-16(10-17)11-18(24)9-15/h1-2,13,15-19,24H,3-12,14H2,(H,28,32)(H,30,31) CIBXWQVHSMWQOJ-UHFFFAOYSA-N 50306426 2-{1'-[(adamantan-2-yl)carbamoyl]-5-chloro-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL605954 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306426&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25065230 104160787 CHEMBL605954 ZINC45374909 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549169 OC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2cc(Cl)ccc12 InChI=1S/C26H33ClN2O3/c27-20-1-2-21-19(12-23(30)31)14-26(22(21)13-20)3-5-29(6-4-26)25(32)28-24-17-8-15-7-16(10-17)11-18(24)9-15/h1-2,13,15-19,24H,3-12,14H2,(H,28,32)(H,30,31) IQFLDKBWKHEUQY-UHFFFAOYSA-N 50306427 2-{1'-[(adamantan-2-yl)carbamoyl]-6-chloro-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL602051 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306427&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25065227 104160788 CHEMBL602051 ZINC45370236 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549170 OC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2c1cccc2Cl InChI=1S/C26H33ClN2O3/c27-21-3-1-2-20-19(13-22(30)31)14-26(23(20)21)4-6-29(7-5-26)25(32)28-24-17-9-15-8-16(11-17)12-18(24)10-15/h1-3,15-19,24H,4-14H2,(H,28,32)(H,30,31) GTRLLSQFXNMEFO-UHFFFAOYSA-N 50306428 2-{1'-[(adamantan-2-yl)carbamoyl]-7-chloro-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL602248 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306428&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25065027 104160789 CHEMBL602248 ZINC45372676 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549171 OC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2c1cccc2Br InChI=1S/C26H33BrN2O3/c27-21-3-1-2-20-19(13-22(30)31)14-26(23(20)21)4-6-29(7-5-26)25(32)28-24-17-9-15-8-16(11-17)12-18(24)10-15/h1-3,15-19,24H,4-14H2,(H,28,32)(H,30,31) GWEYXGKHUJIVFK-UHFFFAOYSA-N 50306429 2-{1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl}acetic acid::CHEMBL605162 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306429&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 46216689 104160790 CHEMBL605162 ZINC45373608 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549172 OC(=O)C[C@@H]1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2c1cccc2Br InChI=1S/C26H33BrN2O3/c27-21-3-1-2-20-19(13-22(30)31)14-26(23(20)21)4-6-29(7-5-26)25(32)28-24-17-9-15-8-16(11-17)12-18(24)10-15/h1-3,15-19,24H,4-14H2,(H,28,32)(H,30,31)/t15?,16?,17?,18?,19-,24?/m1/s1 GWEYXGKHUJIVFK-CYYXOFGOSA-N 50306430 2-[(3S)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl]acetic acid::CHEMBL602249 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306430&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 46216688 104160791 CHEMBL602249 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549173 OC(=O)C[C@H]1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2c1cccc2Br InChI=1S/C26H33BrN2O3/c27-21-3-1-2-20-19(13-22(30)31)14-26(23(20)21)4-6-29(7-5-26)25(32)28-24-17-9-15-8-16(11-17)12-18(24)10-15/h1-3,15-19,24H,4-14H2,(H,28,32)(H,30,31)/t15?,16?,17?,18?,19-,24?/m0/s1 GWEYXGKHUJIVFK-DPQZDQFZSA-N 50306431 2-[(3R)-1'-[(adamantan-2-yl)carbamoyl]-7-bromo-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl]acetic acid::CHEMBL601849 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306431&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 46213656 104160792 CHEMBL601849 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549174 CS(=O)(=O)NC(=O)CC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2c1cccc2Br InChI=1S/C27H36BrN3O4S/c1-36(34,35)30-23(32)14-20-15-27(24-21(20)3-2-4-22(24)28)5-7-31(8-6-27)26(33)29-25-18-10-16-9-17(12-18)13-19(25)11-16/h2-4,16-20,25H,5-15H2,1H3,(H,29,33)(H,30,32) AJHBTWPEUQMWQP-UHFFFAOYSA-N 50306432 CHEMBL601210::N-(adamantan-2-yl)-7-bromo-3-[(methanesulfonylcarbamoyl)methyl]-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306432&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 46231719 104160793 CHEMBL601210 ZINC49763043 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50549175 OCCC1CC2(CCN(CC2)C(=O)NC2C3CC4CC(C3)CC2C4)c2c1cccc2Br InChI=1S/C26H35BrN2O2/c27-22-3-1-2-21-18(4-9-30)15-26(23(21)22)5-7-29(8-6-26)25(31)28-24-19-11-16-10-17(13-19)14-20(24)12-16/h1-3,16-20,24,30H,4-15H2,(H,28,31) FIAGRZHTDXBMMS-UHFFFAOYSA-N 50306434 CHEMBL606420::N-(adamantan-2-yl)-7-bromo-3-(2-hydroxyethyl)-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 9000 ChEMBL 10.1016/j.bmcl.2009.12.082 10.7270/Q2KK9BWZ 20064717 Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306434&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 46231721 104160795 CHEMBL606420 ZINC45387189 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50574374 O=C(N1CCCCC1)C12CC3CC(C1)CC(C3)(C2)c1ccccc1 InChI=1S/C22H29NO/c24-20(23-9-5-2-6-10-23)22-14-17-11-18(15-22)13-21(12-17,16-22)19-7-3-1-4-8-19/h1,3-4,7-8,17-18H,2,5-6,9-16H2 GRJCFVZPAQAKFW-UHFFFAOYSA-N 50317206 (3-Phenyl-adamantan-1-yl)-piperidin-1-yl-methanone::CHEMBL1088379 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2010.03.032 10.7270/Q2NV9JDJ 20363126 Cheng, H; Hoffman, J; Le, P; Nair, SK; Cripps, S; Matthews, J; Smith, C; Yang, M; Kupchinsky, S; Dress, K; Edwards, M; Cole, B; Walters, E; Loh, C; Ermolieff, J; Fanjul, A; Bhat, GB; Herrera, J; Pauly, T; Hosea, N; Paderes, G; Rejto, P Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317206&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 2953793 104151567 CHEMBL1088379 ZINC16320090 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604807 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 MPDGHEJMBKOTSU-YKLVYJNSSA-N 50233538 18beta-glycyrrhetic acid::3beta-hydroxy-11-oxoolean-12-en-30-oic acid::CHEMBL230006::US11660306, Example 18beta Glycyrrhetinic acid::glycyrrhetinic acid 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 257 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50233538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50233538&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CBW 10114 104055693 30853 CHEMBL230006 C02283 ZINC19203131 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604808 CON[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C31H49NO4/c1-26(2)22-9-12-31(7)24(29(22,5)11-10-23(26)32-36-8)21(33)17-19-20-18-28(4,25(34)35)14-13-27(20,3)15-16-30(19,31)6/h17,20,22-24,32H,9-16,18H2,1-8H3,(H,34,35)/t20-,22-,23+,24+,27+,28-,29-,30+,31+/m0/s1 DEBAOVSKKCPBDP-RQJBKSHJSA-N 50329187 (3alpha,18beta,20beta)-3-Methoxyamino-11-oxo-olean-12-en-29-oic acid hydrochloride::CHEMBL1271410 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 4.9 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329187&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52940913 123108302 CHEMBL1271410 ZINC64504117 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604809 CON[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C31H49NO4/c1-26(2)22-9-12-31(7)24(29(22,5)11-10-23(26)32-36-8)21(33)17-19-20-18-28(4,25(34)35)14-13-27(20,3)15-16-30(19,31)6/h17,20,22-24,32H,9-16,18H2,1-8H3,(H,34,35)/t20-,22-,23-,24+,27+,28-,29-,30+,31+/m0/s1 DEBAOVSKKCPBDP-BDANYOJNSA-N 50329188 (3beta,18beta,20beta)-3-Methoxyamino-11-oxo-olean-12-en-29-oic acid hydrochloride::CHEMBL1269877 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 14.5 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329188&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52947144 123108303 CHEMBL1269877 ZINC64527795 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604810 CC(=O)N[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C32H49NO4/c1-19(34)33-24-10-11-30(6)23(27(24,2)3)9-12-32(8)25(30)22(35)17-20-21-18-29(5,26(36)37)14-13-28(21,4)15-16-31(20,32)7/h17,21,23-25H,9-16,18H2,1-8H3,(H,33,34)(H,36,37)/t21-,23-,24-,25+,28+,29-,30-,31+,32+/m0/s1 OROFZAZESKXAEE-XWEVEMRCSA-N 50329189 (3beta,18beta,20beta)-3-(Acetylamino)-11-oxo-olean-12-en-29-oicacid::CHEMBL1270093 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 458 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329189&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52945888 123108304 CHEMBL1270093 ZINC64539125 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604811 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C32H48O5/c1-19(33)37-24-10-11-30(6)23(27(24,2)3)9-12-32(8)25(30)22(34)17-20-21-18-29(5,26(35)36)14-13-28(21,4)15-16-31(20,32)7/h17,21,23-25H,9-16,18H2,1-8H3,(H,35,36)/t21-,23-,24-,25+,28+,29-,30-,31+,32+/m0/s1 FTQDJVZNPJRVPG-XWEVEMRCSA-N 50188385 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::(3beta,18beta,20beta)-3-(Acetyloxy)-11-oxo-olean-12-en-29-oic acid::CHEMBL207413 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 750 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188385&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 94320 104072178 CHEMBL207413 C17734 ZINC34169081 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604812 CC1(C)[C@@H]2CC[C@]3(C)[C@H](C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CCC1=O InChI=1S/C30H44O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21,23H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,23+,26+,27-,28-,29+,30+/m0/s1 QGWDYPREORDRIT-LPXJIFNVSA-N 50329190 (18beta,20beta)-3,11-Dioxo-olean-12-en-29-oic acid::(2S,4aS,6aS,6bR,8aR,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-10,13-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::3,11-Dioxoolean-12-ene-30-oic acid::CHEMBL493512 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 329 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329190&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 111253 123108305 16404 CHEMBL493512 C02943 ZINC38557853 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604813 CO\N=C1/CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C31H47NO4/c1-26(2)22-9-12-31(7)24(29(22,5)11-10-23(26)32-36-8)21(33)17-19-20-18-28(4,25(34)35)14-13-27(20,3)15-16-30(19,31)6/h17,20,22,24H,9-16,18H2,1-8H3,(H,34,35)/b32-23+/t20-,22-,24+,27+,28-,29-,30+,31+/m0/s1 ZVNAOYPTGIUYRO-NLXZVWKGSA-N 50329191 (2S,4aS,6aS,6bR,8aR,12aS,12bR,14bR,E)-10-(methoxyimino)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::CHEMBL1270589 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 268 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329191&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 46229717 123108306 CHEMBL1270589 ZINC45338665 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604814 CN(O)C(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 InChI=1S/C33H51NO5/c1-20(35)39-25-11-12-31(6)24(28(25,2)3)10-13-33(8)26(31)23(36)18-21-22-19-30(5,27(37)34(9)38)15-14-29(22,4)16-17-32(21,33)7/h18,22,24-26,38H,10-17,19H2,1-9H3/t22-,24-,25-,26+,29+,30-,31-,32+,33+/m0/s1 JMPAVZYYYUPQJB-IREBYWSLSA-N 50329192 (3beta,18beta,20beta)-3-Acetoxy-N-methyl-N-hydroxy-11-oxoolean-12-en-29-amide::CHEMBL1269273 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2.9 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329192&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 46894126 123108307 CHEMBL1269273 ZINC64527788 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604815 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(=O)NO)C1(C)C InChI=1S/C32H49NO5/c1-19(34)38-24-10-11-30(6)23(27(24,2)3)9-12-32(8)25(30)22(35)17-20-21-18-29(5,26(36)33-37)14-13-28(21,4)15-16-31(20,32)7/h17,21,23-25,37H,9-16,18H2,1-8H3,(H,33,36)/t21-,23-,24-,25+,28+,29-,30-,31+,32+/m0/s1 OSKOFHMVTLJAQQ-XWEVEMRCSA-N 50329193 (3beta,18beta,20beta)-3-Acetoxy-N-hydroxy-11-oxo-olean-12-en-29-amide::CHEMBL1270688 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 61.1 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329193&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52945350 123108308 CHEMBL1270688 ZINC64513383 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604825 CONC(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 InChI=1S/C31H49NO4/c1-26(2)22-9-12-31(7)24(29(22,5)11-10-23(26)34)21(33)17-19-20-18-28(4,25(35)32-36-8)14-13-27(20,3)15-16-30(19,31)6/h17,20,22-24,34H,9-16,18H2,1-8H3,(H,32,35)/t20-,22-,23-,24+,27+,28-,29-,30+,31+/m0/s1 KZVTVRBLIPGVFA-BDANYOJNSA-N 50329194 (3beta,18beta,20beta)-3-Hydroxy-N-methoxy-11-oxo-olean-12-en-29-amide::CHEMBL1270994 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2130 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329194&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52950107 123108309 CHEMBL1270994 ZINC64528225 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50604827 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(=O)NO InChI=1S/C30H47NO4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)33)20(32)16-18-19-17-27(4,24(34)31-35)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,33,35H,8-15,17H2,1-7H3,(H,31,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 VVDYUUICXHIODD-YKLVYJNSSA-N 50329195 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-N,10-dihydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxamide::CHEMBL1271303 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 122 ChEMBL 10.1016/j.bmc.2010.08.046 10.7270/Q2PR7W7Z 20851614 Stanetty, C; Czollner, L; Koller, I; Shah, P; Gaware, R; Cunha, TD; Odermatt, A; Jordis, U; Kosma, P; Classen-Houben, D University of Natural Resources and Applied Life Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329195&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11190936 123108310 CHEMBL1271303 ZINC38348372 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50605098 NC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)Nc1ncccc1C#N)C(C3)C2 InChI=1S/C22H27N5O3/c23-11-14-2-1-4-25-19(14)26-17-3-5-27(12-17)21(29)30-18-15-6-13-7-16(18)10-22(8-13,9-15)20(24)28/h1-2,4,13,15-18H,3,5-10,12H2,(H2,24,28)(H,25,26)/t13?,15?,16?,17-,18-,22-/m1/s1 BNIGHFUMARRMFX-GPJGMNBASA-N 50329315 (R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid 5-carbamoyl-adamantan-2-yl ester::CHEMBL1269895 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 7350 ChEMBL 10.1016/j.bmcl.2010.08.142 10.7270/Q2X92BJ5 20864344 Tice, CM; Zhao, W; Krosky, PM; Kruk, BA; Berbaum, J; Johnson, JA; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Howard, L; Togias, J; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, PR; Guo, J; Guo, R; Nar, H; Schuler-Metz, A; Gregg, RE; Leftheris, K; Harrison, RK; McGeehan, GM; Zhuang, L; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329315&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52941059 123108430 CHEMBL1269895 ZINC64527183 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50605102 NC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)Nc1ccc(cn1)C#N)C(C3)C2 InChI=1S/C22H27N5O3/c23-10-13-1-2-18(25-11-13)26-17-3-4-27(12-17)21(29)30-19-15-5-14-6-16(19)9-22(7-14,8-15)20(24)28/h1-2,11,14-17,19H,3-9,12H2,(H2,24,28)(H,25,26)/t14?,15?,16?,17-,19-,22-/m1/s1 KYQVHOMHIXJGBI-DOVRNEMHSA-N 50329316 (R)-3-(5-Cyano-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid 5-carbamoyl-adamantan-2-yl ester::CHEMBL1270001 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 8650 ChEMBL 10.1016/j.bmcl.2010.08.142 10.7270/Q2X92BJ5 20864344 Tice, CM; Zhao, W; Krosky, PM; Kruk, BA; Berbaum, J; Johnson, JA; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Howard, L; Togias, J; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, PR; Guo, J; Guo, R; Nar, H; Schuler-Metz, A; Gregg, RE; Leftheris, K; Harrison, RK; McGeehan, GM; Zhuang, L; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329316&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52947102 123108431 CHEMBL1270001 ZINC64527508 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50580072 CC(C)[C@]1(C)SC(N[C@H]2C[C@@H]3CC[C@H]2C3)=NC1=O InChI=1S/C14H22N2OS/c1-8(2)14(3)12(17)16-13(18-14)15-11-7-9-4-5-10(11)6-9/h8-11H,4-7H2,1-3H3,(H,15,16,17)/t9-,10+,11+,14+/m1/s1 YCNCXQNUXCHRRX-ZHPDPMBESA-N 50319665 (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one::AMG-221::CHEMBL1085107 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm100242d 10.7270/Q2WW7HVQ 20465278 Veniant, MM; Hale, C; Hungate, RW; Gahm, K; Emery, MG; Jona, J; Joseph, S; Adams, J; Hague, A; Moniz, G; Zhang, J; Bartberger, MD; Li, V; Syed, R; Jordan, S; Komorowski, R; Chen, MM; Cupples, R; Kim, KW; St Jean, DJ; Johansson, L; Henriksson, MA; Williams, M; Vallgarda, J; Fotsch, C; Wang, M Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50319665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50319665&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25207668 104154026 CHEMBL1085107 ZINC43203373 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630905 CCS(=O)(=O)CC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C21H26F3N3O2S/c1-3-30(28,29)14-19-8-11-20(12-9-19,13-10-19)18-26-25-17(27(18)2)15-6-4-5-7-16(15)21(22,23)24/h4-7H,3,8-14H2,1-2H3 IIUAOVVCEISVLV-UHFFFAOYSA-N 50340386 3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761321 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340386&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44196869 131343322 CHEMBL1761321 ZINC71316756 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630906 CCS(=O)(=O)CCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O2S/c1-3-32(30,31)16-6-9-21-10-13-22(14-11-21,15-12-21)20-28-27-19(29(20)2)17-7-4-5-8-18(17)23(24,25)26/h4-5,7-8H,3,6,9-16H2,1-2H3 ORQZQBUNAMJFCY-UHFFFAOYSA-N 50340401 3-(4-(3-(ethylsulfonyl)propyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761322 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 22591684 131343337 CHEMBL1761322 ZINC03960659 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630907 CCS(=O)(=O)CCCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C24H32F3N3O2S/c1-3-33(31,32)17-7-6-10-22-11-14-23(15-12-22,16-13-22)21-29-28-20(30(21)2)18-8-4-5-9-19(18)24(25,26)27/h4-5,8-9H,3,6-7,10-17H2,1-2H3 OJOIZXGLYDYZSP-UHFFFAOYSA-N 50340402 3-(4-(4-(ethylsulfonyl)butyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761323 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340402&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587123 131343338 CHEMBL1761323 ZINC71330061 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630908 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2Cl)n1C InChI=1S/C21H28ClN3O2S/c1-3-28(26,27)15-14-20-8-11-21(12-9-20,13-10-20)19-24-23-18(25(19)2)16-6-4-5-7-17(16)22/h4-7H,3,8-15H2,1-2H3 UEVJSVSXEAWSIN-UHFFFAOYSA-N 50340379 3-(2-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761324 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340379&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582262 131343315 CHEMBL1761324 ZINC71319326 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630909 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2cccc(Cl)c2)n1C InChI=1S/C21H28ClN3O2S/c1-3-28(26,27)14-13-20-7-10-21(11-8-20,12-9-20)19-24-23-18(25(19)2)16-5-4-6-17(22)15-16/h4-6,15H,3,7-14H2,1-2H3 FDUGOQBNTQPANC-UHFFFAOYSA-N 50340390 3-(3-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761325 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340390&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580243 131343326 CHEMBL1761325 ZINC71316699 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630910 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccc(Cl)cc2)n1C InChI=1S/C21H28ClN3O2S/c1-3-28(26,27)15-14-20-8-11-21(12-9-20,13-10-20)19-24-23-18(25(19)2)16-4-6-17(22)7-5-16/h4-7H,3,8-15H2,1-2H3 ADLLAELRQCIVNK-UHFFFAOYSA-N 50340393 3-(4-chlorophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761326 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340393&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583234 131343329 CHEMBL1761326 ZINC71316374 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630911 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccc(O)cc2Cl)n1C InChI=1S/C21H28ClN3O3S/c1-3-29(27,28)13-12-20-6-9-21(10-7-20,11-8-20)19-24-23-18(25(19)2)16-5-4-15(26)14-17(16)22/h4-5,14,26H,3,6-13H2,1-2H3 DKVFLOAIDJATMS-UHFFFAOYSA-N 50340403 3-chloro-4-(5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazol-3-yl)phenol::CHEMBL1761327 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340403&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11201450 131343339 CHEMBL1761327 ZINC38359947 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630912 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2Br)n1C InChI=1S/C21H28BrN3O2S/c1-3-28(26,27)15-14-20-8-11-21(12-9-20,13-10-20)19-24-23-18(25(19)2)16-6-4-5-7-17(16)22/h4-7H,3,8-15H2,1-2H3 VRYRRYFFSYUFNW-UHFFFAOYSA-N 50340381 3-(2-bromophenyl)-5-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761328 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340381&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587124 131343317 CHEMBL1761328 ZINC71316977 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630913 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C)n1C InChI=1S/C22H31N3O2S/c1-4-28(26,27)16-15-21-9-12-22(13-10-21,14-11-21)20-24-23-19(25(20)3)18-8-6-5-7-17(18)2/h5-8H,4,9-16H2,1-3H3 BRPRVVJRJMNSBE-UHFFFAOYSA-N 50340385 3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-o-tolyl-4H-1,2,4-triazole::CHEMBL1761329 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340385&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584198 131343321 CHEMBL1761329 ZINC71330680 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630914 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2F)n1C InChI=1S/C21H28FN3O2S/c1-3-28(26,27)15-14-20-8-11-21(12-9-20,13-10-20)19-24-23-18(25(19)2)16-6-4-5-7-17(16)22/h4-7H,3,8-15H2,1-2H3 LOLPZHHJXGSPLZ-UHFFFAOYSA-N 50340388 3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-fluorophenyl)-4-methyl-4H-1,2,4-triazole::CHEMBL1761330 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340388&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585157 131343324 CHEMBL1761330 ZINC71388881 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631066 CC1COc2ccccc2N1C(=O)N1CCC(CC1)c1cnc[nH]1 InChI=1S/C18H22N4O2/c1-13-11-24-17-5-3-2-4-16(17)22(13)18(23)21-8-6-14(7-9-21)15-10-19-12-20-15/h2-5,10,12-14H,6-9,11H2,1H3,(H,19,20) IKCNXAIMXSHWAH-UHFFFAOYSA-N 50340432 (4-(1H-imidazol-4-yl)piperidin-1-yl)(3-methyl-2H-benzo[b][1,4]oxazin-4(3H)-yl)methanone::CHEMBL1761843 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10 ChEMBL 10.1016/j.bmcl.2011.02.111 10.7270/Q26H4HQS 21439819 Venier, O; Pascal, C; Braun, A; Namane, C; Mougenot, P; Crespin, O; Pacquet, F; Mougenot, C; Monseau, C; Onofri, B; Dadji-Faihun, R; Leger, C; Ben-Hassine, M; Van-Pham, T; Ragot, JL; Philippo, C; Gussregen, S; Engel, C; Farjot, G; Noah, L; Maniani, K; Nicolai, E Sanofi-Aventis R&D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340432&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24896012 131343368 CHEMBL1761843 ZINC71317054 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631067 O=C(N1CCC(CC1)c1cnc[nH]1)N1CCCc2ccccc12 InChI=1S/C18H22N4O/c23-18(22-9-3-5-15-4-1-2-6-17(15)22)21-10-7-14(8-11-21)16-12-19-13-20-16/h1-2,4,6,12-14H,3,5,7-11H2,(H,19,20) UTSIHHDNMUZNMG-UHFFFAOYSA-N 50340431 (4-(1H-imidazol-4-yl)piperidin-1-yl)(3,4-dihydroquinolin-1(2H)-yl)methanone::CHEMBL1761844 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10 ChEMBL 10.1016/j.bmcl.2011.02.111 10.7270/Q26H4HQS 21439819 Venier, O; Pascal, C; Braun, A; Namane, C; Mougenot, P; Crespin, O; Pacquet, F; Mougenot, C; Monseau, C; Onofri, B; Dadji-Faihun, R; Leger, C; Ben-Hassine, M; Van-Pham, T; Ragot, JL; Philippo, C; Gussregen, S; Engel, C; Farjot, G; Noah, L; Maniani, K; Nicolai, E Sanofi-Aventis R&D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340431&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search S05 24895969 131343367 CHEMBL1761844 ZINC71318598 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631096 COc1ccc(cc1)-c1cnc(nc1)N1CCN(C(=O)N2CCC(C2)c2cn[nH]c2)c2ccccc12 InChI=1S/C27H27N7O2/c1-36-23-8-6-19(7-9-23)21-14-28-26(29-15-21)33-12-13-34(25-5-3-2-4-24(25)33)27(35)32-11-10-20(18-32)22-16-30-31-17-22/h2-9,14-17,20H,10-13,18H2,1H3,(H,30,31) RHSTYEXBNNRSAD-UHFFFAOYSA-N 50340433 (3-(1H-pyrazol-4-yl)pyrrolidin-1-yl)(4-(5-(4-methoxyphenyl)pyrimidin-2-yl)-3,4-dihydroquinoxalin-1(2H)-yl)methanone::CHEMBL1761869 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2011.02.111 10.7270/Q26H4HQS 21439819 Venier, O; Pascal, C; Braun, A; Namane, C; Mougenot, P; Crespin, O; Pacquet, F; Mougenot, C; Monseau, C; Onofri, B; Dadji-Faihun, R; Leger, C; Ben-Hassine, M; Van-Pham, T; Ragot, JL; Philippo, C; Gussregen, S; Engel, C; Farjot, G; Noah, L; Maniani, K; Nicolai, E Sanofi-Aventis R&D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340433&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52918012 131343369 CHEMBL1761869 ZINC71318228 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631928 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(N)cc1 InChI=1S/C19H19ClN4/c1-24-17(13-3-9-16(21)10-4-13)22-23-18(24)19(11-2-12-19)14-5-7-15(20)8-6-14/h3-10H,2,11-12,21H2,1H3 WCWFBOFEKMTOAY-UHFFFAOYSA-N 50340791 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)aniline::CHEMBL1760682 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3100 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340791&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582136 131343727 CHEMBL1760682 ZINC71330025 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631929 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(N)cc1Cl InChI=1S/C19H18Cl2N4/c1-25-17(15-8-7-14(22)11-16(15)21)23-24-18(25)19(9-2-10-19)12-3-5-13(20)6-4-12/h3-8,11H,2,9-10,22H2,1H3 DQXJSPWIZXASJC-UHFFFAOYSA-N 50340806 3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)aniline::CHEMBL1760688 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2300 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340806&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581096 131343742 CHEMBL1760688 ZINC71319343 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631930 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccsc1 InChI=1S/C23H20ClN3S/c1-27-21(17-5-3-16(4-6-17)18-11-14-28-15-18)25-26-22(27)23(12-2-13-23)19-7-9-20(24)10-8-19/h3-11,14-15H,2,12-13H2,1H3 PUEDNZRROPNXTL-UHFFFAOYSA-N 50340798 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-(4-(thiophen-3-yl)phenyl)-4H-1,2,4-triazole::CHEMBL1760801 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340798&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584120 131343734 CHEMBL1760801 ZINC71296964 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631931 C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCCn12 InChI=1S/C18H27N3/c1-2-4-6-21-16(5-3-1)19-20-17(21)18-10-13-7-14(11-18)9-15(8-13)12-18/h13-15H,1-12H2 KTYRDCHIMJKQQH-UHFFFAOYSA-N 50340809 3-Adamantan-1-yl-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL256778 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340809&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10308303 131343745 CHEMBL256778 ZINC29045264 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631933 Clc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22ClN3/c19-15-9-7-14(8-10-15)18(11-5-12-18)17-21-20-16-6-3-1-2-4-13-22(16)17/h7-10H,1-6,11-13H2 FDLFGCPTRMXATH-UHFFFAOYSA-N 50239407 3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::3-[1-(4-Chloro-phenyl)-cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL257149 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239407&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10335880 104056508 CHEMBL257149 ZINC29044661 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631935 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccccc1 InChI=1S/C19H18ClN3/c1-23-17(14-6-3-2-4-7-14)21-22-18(23)19(12-5-13-19)15-8-10-16(20)11-9-15/h2-4,6-11H,5,12-13H2,1H3 AMRNFCHSNOKVDZ-UHFFFAOYSA-N 50260623 3-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-5-phenyl-4H-1,2,4-triazole::CHEMBL523177 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260623&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724899 104110113 CHEMBL523177 ZINC40425335 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631937 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C25H22ClN3/c1-29-23(20-10-8-19(9-11-20)18-6-3-2-4-7-18)27-28-24(29)25(16-5-17-25)21-12-14-22(26)15-13-21/h2-4,6-15H,5,16-17H2,1H3 UXOKGMBZBAXMDM-UHFFFAOYSA-N 50260797 3-Biphenyl-4-yl-5-[1-(4-chloro-phenyl)-cyclobutyl]-4-methyl-4H-[1,2,4]triazole::CHEMBL525361 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260797&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10340916 104110217 CHEMBL525361 ZINC38558781 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631939 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(O)=O InChI=1S/C20H18ClN3O2/c1-24-17(13-3-5-14(6-4-13)18(25)26)22-23-19(24)20(11-2-12-20)15-7-9-16(21)10-8-15/h3-10H,2,11-12H2,1H3,(H,25,26) UQMHXMBURPDAGQ-UHFFFAOYSA-N 50340810 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzoic acid::CHEMBL1760671 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340810&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585028 131343746 CHEMBL1760671 ZINC71317746 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631941 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(N)=O InChI=1S/C20H19ClN4O/c1-25-18(14-5-3-13(4-6-14)17(22)26)23-24-19(25)20(11-2-12-20)15-7-9-16(21)10-8-15/h3-10H,2,11-12H2,1H3,(H2,22,26) MXXLRXZZQGJLCI-UHFFFAOYSA-N 50340811 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzamide::CHEMBL1760672 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340811&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580118 131343747 CHEMBL1760672 ZINC71329667 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631953 CCNC(=O)c1ccc(cc1)-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C22H23ClN4O/c1-3-24-20(28)16-7-5-15(6-8-16)19-25-26-21(27(19)2)22(13-4-14-22)17-9-11-18(23)12-10-17/h5-12H,3-4,13-14H2,1-2H3,(H,24,28) ODDNAPFVJHVOLT-UHFFFAOYSA-N 50340822 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-N-ethylbenzamide::CHEMBL1760673 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340822&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585029 131343758 CHEMBL1760673 ZINC71329189 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631955 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)NC(C)(C)C InChI=1S/C24H27ClN4O/c1-23(2,3)26-21(30)17-8-6-16(7-9-17)20-27-28-22(29(20)4)24(14-5-15-24)18-10-12-19(25)13-11-18/h6-13H,5,14-15H2,1-4H3,(H,26,30) KBPXVIBNWBHKIX-UHFFFAOYSA-N 50340823 CHEMBL1760674::N-tert-butyl-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340823&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581094 131343759 CHEMBL1760674 ZINC71317458 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631957 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)NC1CC1 InChI=1S/C23H23ClN4O/c1-28-20(15-3-5-16(6-4-15)21(29)25-19-11-12-19)26-27-22(28)23(13-2-14-23)17-7-9-18(24)10-8-17/h3-10,19H,2,11-14H2,1H3,(H,25,29) ZXLFWPREOVAREF-UHFFFAOYSA-N 50340824 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-N-cyclopropylbenzamide::CHEMBL1760675 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340824&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582134 131343760 CHEMBL1760675 ZINC71316040 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631959 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)NC1CCC1 InChI=1S/C24H25ClN4O/c1-29-21(16-6-8-17(9-7-16)22(30)26-20-4-2-5-20)27-28-23(29)24(14-3-15-24)18-10-12-19(25)13-11-18/h6-13,20H,2-5,14-15H2,1H3,(H,26,30) INFTUHKDVWAXHL-UHFFFAOYSA-N 50340825 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-N-cyclobutylbenzamide::CHEMBL1760676 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340825&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584081 131343761 CHEMBL1760676 ZINC71329278 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631961 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)N1CCC1 InChI=1S/C23H23ClN4O/c1-27-20(16-4-6-17(7-5-16)21(29)28-14-3-15-28)25-26-22(27)23(12-2-13-23)18-8-10-19(24)11-9-18/h4-11H,2-3,12-15H2,1H3 OYMOQCSFDUOSAA-UHFFFAOYSA-N 50340826 CHEMBL1760677::azetidin-1-yl(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)methanone 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340826&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582135 131343762 CHEMBL1760677 ZINC71330976 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631963 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)N1CCCC1 InChI=1S/C24H25ClN4O/c1-28-21(17-5-7-18(8-6-17)22(30)29-15-2-3-16-29)26-27-23(28)24(13-4-14-24)19-9-11-20(25)12-10-19/h5-12H,2-4,13-16H2,1H3 HNNUFGHXZACPCD-UHFFFAOYSA-N 50340827 (4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)(pyrrolidin-1-yl)methanone::CHEMBL1760678 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340827&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586966 131343763 CHEMBL1760678 ZINC71296388 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631965 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)C(=O)N1CCOCC1 InChI=1S/C24H25ClN4O2/c1-28-21(17-3-5-18(6-4-17)22(30)29-13-15-31-16-14-29)26-27-23(28)24(11-2-12-24)19-7-9-20(25)10-8-19/h3-10H,2,11-16H2,1H3 TVALZOHSDGHVGI-UHFFFAOYSA-N 50340828 (4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)(morpholino)methanone::CHEMBL1760679 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340828&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583079 131343764 CHEMBL1760679 ZINC71318971 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631967 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)C(O)=O InChI=1S/C20H17Cl2N3O2/c1-25-17(15-8-3-12(18(26)27)11-16(15)22)23-24-19(25)20(9-2-10-20)13-4-6-14(21)7-5-13/h3-8,11H,2,9-10H2,1H3,(H,26,27) CXEOROMWHNWONF-UHFFFAOYSA-N 50340829 3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzoic acid::CHEMBL1760680 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340829&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586967 131343765 CHEMBL1760680 ZINC71318854 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631969 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)C(N)=O InChI=1S/C20H18Cl2N4O/c1-26-18(15-8-3-12(17(23)27)11-16(15)22)24-25-19(26)20(9-2-10-20)13-4-6-14(21)7-5-13/h3-8,11H,2,9-10H2,1H3,(H2,23,27) XRKNMGUUBWDXPL-UHFFFAOYSA-N 50340830 3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)benzamide::CHEMBL1760681 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340830&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581095 131343766 CHEMBL1760681 ZINC71315860 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631971 CC(=O)Nc1ccc(cc1)-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C21H21ClN4O/c1-14(27)23-18-10-4-15(5-11-18)19-24-25-20(26(19)2)21(12-3-13-21)16-6-8-17(22)9-7-16/h4-11H,3,12-13H2,1-2H3,(H,23,27) RTSUBSMHFCWFJT-UHFFFAOYSA-N 50340792 CHEMBL1760683::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340792&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585992 131343728 CHEMBL1760683 ZINC71296938 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631973 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(NC(=O)c2cnccn2)cc1 InChI=1S/C24H21ClN6O/c1-31-21(16-3-9-19(10-4-16)28-22(32)20-15-26-13-14-27-20)29-30-23(31)24(11-2-12-24)17-5-7-18(25)8-6-17/h3-10,13-15H,2,11-12H2,1H3,(H,28,32) KVYXNQKSZCVHLF-UHFFFAOYSA-N 50340793 CHEMBL1760684::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrazine-2-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340793&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585993 131343729 CHEMBL1760684 ZINC71329550 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631975 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(NC(=O)c2cccs2)cc1 InChI=1S/C24H21ClN4OS/c1-29-21(16-5-11-19(12-6-16)26-22(30)20-4-2-15-31-20)27-28-23(29)24(13-3-14-24)17-7-9-18(25)10-8-17/h2,4-12,15H,3,13-14H2,1H3,(H,26,30) VHQQNMOPJCVPFS-UHFFFAOYSA-N 50340794 CHEMBL1760685::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)thiophene-2-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340794&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585994 131343730 CHEMBL1760685 ZINC71329913 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631977 Cc1cc(C(=O)Nc2ccc(cc2)-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(C)o1 InChI=1S/C26H25ClN4O2/c1-16-15-22(17(2)33-16)24(32)28-21-11-5-18(6-12-21)23-29-30-25(31(23)3)26(13-4-14-26)19-7-9-20(27)10-8-19/h5-12,15H,4,13-14H2,1-3H3,(H,28,32) CGWGMYIJFORQBT-UHFFFAOYSA-N 50340795 CHEMBL1760686::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-2,5-dimethylfuran-3-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340795&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586968 131343731 CHEMBL1760686 ZINC71316710 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631979 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(NC(=O)c2ccno2)cc1 InChI=1S/C23H20ClN5O2/c1-29-20(15-3-9-18(10-4-15)26-21(30)19-11-14-25-31-19)27-28-22(29)23(12-2-13-23)16-5-7-17(24)8-6-16/h3-11,14H,2,12-13H2,1H3,(H,26,30) GYGISWPQEUFTKD-UHFFFAOYSA-N 50340796 CHEMBL1760687::N-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)isoxazole-5-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340796&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586969 131343732 CHEMBL1760687 ZINC71329653 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631981 CC(=O)Nc1ccc(-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(Cl)c1 InChI=1S/C21H20Cl2N4O/c1-13(28)24-16-8-9-17(18(23)12-16)19-25-26-20(27(19)2)21(10-3-11-21)14-4-6-15(22)7-5-14/h4-9,12H,3,10-11H2,1-2H3,(H,24,28) VTGIWYUUZDTUEM-UHFFFAOYSA-N 50340807 CHEMBL1760689::N-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)acetamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340807&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583080 131343743 CHEMBL1760689 ZINC71319288 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631983 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(NC(=O)c2cnccn2)cc1Cl InChI=1S/C24H20Cl2N6O/c1-32-21(30-31-23(32)24(9-2-10-24)15-3-5-16(25)6-4-15)18-8-7-17(13-19(18)26)29-22(33)20-14-27-11-12-28-20/h3-8,11-14H,2,9-10H2,1H3,(H,29,33) KYSJDYIKEDDRFU-UHFFFAOYSA-N 50340808 CHEMBL1760690::N-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrazine-2-carboxamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340808&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585030 131343744 CHEMBL1760690 ZINC71316317 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631985 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cncnc1 InChI=1S/C23H20ClN5/c1-29-21(17-5-3-16(4-6-17)18-13-25-15-26-14-18)27-28-22(29)23(11-2-12-23)19-7-9-20(24)10-8-19/h3-10,13-15H,2,11-12H2,1H3 GDYZOSVGSBKPLL-UHFFFAOYSA-N 50340812 5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrimidine::CHEMBL1760691 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340812&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582137 131343748 CHEMBL1760691 ZINC71315861 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631987 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cnc(N)nc1 InChI=1S/C23H21ClN6/c1-30-20(16-5-3-15(4-6-16)17-13-26-22(25)27-14-17)28-29-21(30)23(11-2-12-23)18-7-9-19(24)10-8-18/h3-10,13-14H,2,11-12H2,1H3,(H2,25,26,27) QCWFVPXCLWDYJM-UHFFFAOYSA-N 50340813 5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrimidin-2-amine::CHEMBL1760791 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340813&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586030 131343749 CHEMBL1760791 ZINC71329982 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631989 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cnc(=O)[nH]c1 InChI=1S/C23H20ClN5O/c1-29-20(16-5-3-15(4-6-16)17-13-25-22(30)26-14-17)27-28-21(29)23(11-2-12-23)18-7-9-19(24)10-8-18/h3-10,13-14H,2,11-12H2,1H3,(H,25,26,30) CATBWTNVXOHMMB-UHFFFAOYSA-N 50340814 5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrimidin-2-ol::CHEMBL1760792 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340814&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583125 131343750 CHEMBL1760792 ZINC71296997 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631991 COc1ncc(-c2ccc(cc2)-c2nnc(n2C)C2(CCC2)c2ccc(Cl)cc2)c(OC)n1 InChI=1S/C25H24ClN5O2/c1-31-21(29-30-23(31)25(13-4-14-25)18-9-11-19(26)12-10-18)17-7-5-16(6-8-17)20-15-27-24(33-3)28-22(20)32-2/h5-12,15H,4,13-14H2,1-3H3 TYBKJRHHHDQHNG-UHFFFAOYSA-N 50340815 5-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-2,4-dimethoxypyrimidine::CHEMBL1760793 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340815&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583126 131343751 CHEMBL1760793 ZINC71329555 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631993 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cnccn1 InChI=1S/C23H20ClN5/c1-29-21(17-5-3-16(4-6-17)20-15-25-13-14-26-20)27-28-22(29)23(11-2-12-23)18-7-9-19(24)10-8-18/h3-10,13-15H,2,11-12H2,1H3 PZAIZRLLCHXVBJ-UHFFFAOYSA-N 50340816 2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrazine::CHEMBL1760794 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340816&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584119 131343752 CHEMBL1760794 ZINC71318937 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631995 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cc(=O)[nH]cn1 InChI=1S/C23H20ClN5O/c1-29-21(16-5-3-15(4-6-16)19-13-20(30)26-14-25-19)27-28-22(29)23(11-2-12-23)17-7-9-18(24)10-8-17/h3-10,13-14H,2,11-12H2,1H3,(H,25,26,30) GLTVSVCSEZJLOH-UHFFFAOYSA-N 50340817 6-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrimidin-4-ol::CHEMBL1760795 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340817&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585052 131343753 CHEMBL1760795 ZINC71296411 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631997 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccc(Cl)nn1 InChI=1S/C23H19Cl2N5/c1-30-21(16-5-3-15(4-6-16)19-11-12-20(25)27-26-19)28-29-22(30)23(13-2-14-23)17-7-9-18(24)10-8-17/h3-12H,2,13-14H2,1H3 VKCZFLMKNCMHFB-UHFFFAOYSA-N 50340818 3-chloro-6-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyridazine::CHEMBL1760796 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340818&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585053 131343754 CHEMBL1760796 ZINC71296889 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50631999 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccc(N)nn1 InChI=1S/C23H21ClN6/c1-30-21(16-5-3-15(4-6-16)19-11-12-20(25)27-26-19)28-29-22(30)23(13-2-14-23)17-7-9-18(24)10-8-17/h3-12H,2,13-14H2,1H3,(H2,25,27) NTOCENJFNJYPRA-UHFFFAOYSA-N 50340819 6-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyridazin-3-amine::CHEMBL1760797 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340819&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583127 131343755 CHEMBL1760797 ZINC71317019 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632001 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1cnoc1 InChI=1S/C22H19ClN4O/c1-27-20(16-5-3-15(4-6-16)17-13-24-28-14-17)25-26-21(27)22(11-2-12-22)18-7-9-19(23)10-8-18/h3-10,13-14H,2,11-12H2,1H3 JBFDRORHJJBVHA-UHFFFAOYSA-N 50340820 4-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)isoxazole::CHEMBL1760798 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340820&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586031 131343756 CHEMBL1760798 ZINC71296898 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632003 Cc1noc(C)c1-c1ccc(cc1)-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1 InChI=1S/C24H23ClN4O/c1-15-21(16(2)30-28-15)17-5-7-18(8-6-17)22-26-27-23(29(22)3)24(13-4-14-24)19-9-11-20(25)12-10-19/h5-12H,4,13-14H2,1-3H3 ZDDWKCLVBKVFGA-UHFFFAOYSA-N 50340821 4-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-3,5-dimethylisoxazole::CHEMBL1760799 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340821&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583128 131343757 CHEMBL1760799 ZINC71315951 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632005 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1)-c1ccon1 InChI=1S/C22H19ClN4O/c1-27-20(16-5-3-15(4-6-16)19-11-14-28-26-19)24-25-21(27)22(12-2-13-22)17-7-9-18(23)10-8-17/h3-11,14H,2,12-13H2,1H3 WJBGLLMXJGXWLR-UHFFFAOYSA-N 50340797 3-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)isoxazole::CHEMBL1760800 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340797&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54585054 131343733 CHEMBL1760800 ZINC71330965 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632007 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1cccnc1 InChI=1S/C24H20Cl2N4/c1-30-22(20-10-5-16(14-21(20)26)17-4-2-13-27-15-17)28-29-23(30)24(11-3-12-24)18-6-8-19(25)9-7-18/h2,4-10,13-15H,3,11-12H2,1H3 RAQAZKICFNGDBP-UHFFFAOYSA-N 50260908 3-(3-chloro-4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyridine::CHEMBL522701 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260908&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44576846 104110257 CHEMBL522701 ZINC40430308 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632009 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1F)-c1cccnc1 InChI=1S/C24H20ClFN4/c1-30-22(20-10-5-16(14-21(20)26)17-4-2-13-27-15-17)28-29-23(30)24(11-3-12-24)18-6-8-19(25)9-7-18/h2,4-10,13-15H,3,11-12H2,1H3 PRPPOLVIRDINKM-UHFFFAOYSA-N 50340799 3-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-fluorophenyl)pyridine::CHEMBL1760802 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340799&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581137 131343735 CHEMBL1760802 ZINC71315894 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632011 COc1cc(ccc1-c1nnc(n1C)C1(CCC1)c1ccc(Cl)cc1)-c1cccnc1 InChI=1S/C25H23ClN4O/c1-30-23(21-11-6-17(15-22(21)31-2)18-5-3-14-27-16-18)28-29-24(30)25(12-4-13-25)19-7-9-20(26)10-8-19/h3,5-11,14-16H,4,12-13H2,1-2H3 RBGKTPBXYABVOH-UHFFFAOYSA-N 50340800 3-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-methoxyphenyl)pyridine::CHEMBL1760803 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340800&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587012 131343736 CHEMBL1760803 ZINC71315878 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632013 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1O)-c1cccnc1 InChI=1S/C24H21ClN4O/c1-29-22(20-10-5-16(14-21(20)30)17-4-2-13-26-15-17)27-28-23(29)24(11-3-12-24)18-6-8-19(25)9-7-18/h2,4-10,13-15,30H,3,11-12H2,1H3 ZSTHUWVKZPCGCW-UHFFFAOYSA-N 50340801 2-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-5-(pyridin-3-yl)phenol::CHEMBL1760804 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340801&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581138 131343737 CHEMBL1760804 ZINC71318202 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632015 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1F)-c1cnccn1 InChI=1S/C23H19ClFN5/c1-30-21(18-8-3-15(13-19(18)25)20-14-26-11-12-27-20)28-29-22(30)23(9-2-10-23)16-4-6-17(24)7-5-16/h3-8,11-14H,2,9-10H2,1H3 PLKKSSJPSJWGPI-UHFFFAOYSA-N 50340802 2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-fluorophenyl)pyrazine::CHEMBL1760805 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340802&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584121 131343738 CHEMBL1760805 ZINC71330044 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630841 CCCCCC12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C21H35N3/c1-2-3-7-10-20-11-14-21(15-12-20,16-13-20)19-23-22-18-9-6-4-5-8-17-24(18)19/h2-17H2,1H3 HISKJZZJMYSEGO-UHFFFAOYSA-N 50174285 3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL200513 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174285&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11771845 104060103 CHEMBL200513 ZINC06717978 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630843 CC(O)CCCC12CCC(CC1)(CC2)c1nnc2CCCCCCn12 InChI=1S/C21H35N3O/c1-17(25)7-6-9-20-10-13-21(14-11-20,15-12-20)19-23-22-18-8-4-2-3-5-16-24(18)19/h17,25H,2-16H2,1H3 OYOODXKCWJLXMH-UHFFFAOYSA-N 50340383 5-(4-(5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocin-3-yl)bicyclo[2.2.2]octan-1-yl)pentan-2-ol::CHEMBL1761135 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 290 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340383&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11484764 131343319 CHEMBL1761135 ZINC71318888 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630844 Cn1c(nnc1C12CCC(COc3ccc(Cl)cc3)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C25H25ClF3N3O/c1-32-21(19-4-2-3-5-20(19)25(27,28)29)30-31-22(32)24-13-10-23(11-14-24,12-15-24)16-33-18-8-6-17(26)7-9-18/h2-9H,10-16H2,1H3 UVDHSOZENUAPIZ-UHFFFAOYSA-N 50340389 3-(4-((4-chlorophenoxy)methyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761142 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 460 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340389&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587090 131343325 CHEMBL1761142 ZINC71329695 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632019 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1C(N)=O)-c1cnccn1 InChI=1S/C24H21ClN6O/c1-31-22(18-8-3-15(13-19(18)21(26)32)20-14-27-11-12-28-20)29-30-23(31)24(9-2-10-24)16-4-6-17(25)7-5-16/h3-8,11-14H,2,9-10H2,1H3,(H2,26,32) XASSWSVGUZPMFR-UHFFFAOYSA-N 50340804 2-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-5-(pyrazin-2-yl)benzamide::CHEMBL1760807 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340804&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580143 131343740 CHEMBL1760807 ZINC71317721 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632021 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1C(N)=O)C(N)=O InChI=1S/C21H20ClN5O2/c1-27-19(15-8-3-12(17(23)28)11-16(15)18(24)29)25-26-20(27)21(9-2-10-21)13-4-6-14(22)7-5-13/h3-8,11H,2,9-10H2,1H3,(H2,23,28)(H2,24,29) GDQHXKRHLIAGIA-UHFFFAOYSA-N 50340805 4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)isophthalamide::CHEMBL1760808 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340805&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582164 131343741 CHEMBL1760808 ZINC71296487 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632023 Cn1c(nnc1C1(CC(F)C1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1cnccn1 InChI=1S/C23H18Cl2FN5/c1-31-21(18-7-2-14(10-19(18)25)20-13-27-8-9-28-20)29-30-22(31)23(11-17(26)12-23)15-3-5-16(24)6-4-15/h2-10,13,17H,11-12H2,1H3 QYSSEJDAEHAKCS-UHFFFAOYSA-N 50340831 2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrazine::CHEMBL1760809 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340831&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580144 131343767 CHEMBL1760809 ZINC71296493 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50632017 Cn1c(nnc1C1(CCC1)c1ccc(Cl)cc1)-c1ccc(cc1OC(F)F)-c1cnccn1 InChI=1S/C24H20ClF2N5O/c1-32-21(30-31-22(32)24(9-2-10-24)16-4-6-17(25)7-5-16)18-8-3-15(13-20(18)33-23(26)27)19-14-28-11-12-29-19/h3-8,11-14,23H,2,9-10H2,1H3 HJGWKHPIIUHDTI-UHFFFAOYSA-N 50340803 2-(4-(5-(1-(4-chlorophenyl)cyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)-3-(difluoromethoxy)phenyl)pyrazine::CHEMBL1760806 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.125 10.7270/Q2W37WNN 21334894 Sun, W; Maletic, M; Mundt, SS; Shah, K; Zokian, H; Lyons, K; Waddell, ST; Balkovec, J Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340803&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584122 131343739 CHEMBL1760806 ZINC71317759 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629733 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 MPDGHEJMBKOTSU-YKLVYJNSSA-N 50233538 18beta-glycyrrhetic acid::3beta-hydroxy-11-oxoolean-12-en-30-oic acid::CHEMBL230006::US11660306, Example 18beta Glycyrrhetinic acid::glycyrrhetinic acid 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 257 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50233538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50233538&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CBW 10114 104055693 30853 CHEMBL230006 C02283 ZINC19203131 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629734 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C32H48O5/c1-19(33)37-24-10-11-30(6)23(27(24,2)3)9-12-32(8)25(30)22(34)17-20-21-18-29(5,26(35)36)14-13-28(21,4)15-16-31(20,32)7/h17,21,23-25H,9-16,18H2,1-8H3,(H,35,36)/t21-,23-,24-,25+,28+,29-,30-,31+,32+/m0/s1 FTQDJVZNPJRVPG-XWEVEMRCSA-N 50188385 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-acetoxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::(3beta,18beta,20beta)-3-(Acetyloxy)-11-oxo-olean-12-en-29-oic acid::CHEMBL207413 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 750 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50188385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50188385&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 94320 104072178 CHEMBL207413 C17734 ZINC34169081 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629735 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](Oc5nc(=O)o[nH]5)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O InChI=1S/C32H46N2O6/c1-27(2)21-8-11-32(7)23(30(21,5)10-9-22(27)39-25-33-26(38)40-34-25)20(35)16-18-19-17-29(4,24(36)37)13-12-28(19,3)14-15-31(18,32)6/h16,19,21-23H,8-15,17H2,1-7H3,(H,36,37)(H,33,34,38)/t19-,21-,22-,23+,28+,29-,30-,31+,32+/m0/s1 KVESHABINXPVER-UOEOWSRYSA-N 50339805 (3beta,18beta,20beta)-[3-(1,2,4-Oxadiazole-5(2H)-one)]-11-oxoolean-12-en-29-oic acid::CHEMBL1689172 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 11 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339805&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 53317520 125089907 CHEMBL1689172 ZINC66114619 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629736 CN(O)C(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 InChI=1S/C33H51NO5/c1-20(35)39-25-11-12-31(6)24(28(25,2)3)10-13-33(8)26(31)23(36)18-21-22-19-30(5,27(37)34(9)38)15-14-29(22,4)16-17-32(21,33)7/h18,22,24-26,38H,10-17,19H2,1-9H3/t22-,24-,25-,26+,29+,30-,31-,32+,33+/m0/s1 JMPAVZYYYUPQJB-IREBYWSLSA-N 50329192 (3beta,18beta,20beta)-3-Acetoxy-N-methyl-N-hydroxy-11-oxoolean-12-en-29-amide::CHEMBL1269273 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2.9 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50329192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50329192&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 46894126 123108307 CHEMBL1269273 ZINC64527788 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629737 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)NC(N)=O)C1(C)C InChI=1S/C32H50N2O4/c1-19(35)38-24-10-11-30(6)23(27(24,2)3)9-12-32(8)25(30)22(36)17-20-21-18-29(5,34-26(33)37)15-13-28(21,4)14-16-31(20,32)7/h17,21,23-25H,9-16,18H2,1-8H3,(H3,33,34,37)/t21-,23-,24-,25+,28+,29-,30-,31+,32+/m0/s1 WBHDMKZEFCLSRV-XWEVEMRCSA-N 50339806 (3beta,18beta,20beta)-N-[-3-(Acetoxy)-11-oxo-30-norolean-12-en-20-yl]urea::CHEMBL1689173 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 104 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339806&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 53322740 125089908 CHEMBL1689173 ZINC66124247 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629738 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)NC(=O)NS(=O)(=O)C(F)(F)F)C1(C)C InChI=1S/C33H49F3N2O6S/c1-19(39)44-24-10-11-30(6)23(27(24,2)3)9-12-32(8)25(30)22(40)17-20-21-18-29(5,15-13-28(21,4)14-16-31(20,32)7)37-26(41)38-45(42,43)33(34,35)36/h17,21,23-25H,9-16,18H2,1-8H3,(H2,37,38,41)/t21-,23-,24-,25+,28+,29-,30-,31+,32+/m0/s1 WAYRKSNQTDOQAT-XWEVEMRCSA-N 50339807 CHEMBL1689277::N-[(3beta,18beta,20beta)-3-(Acetoxy)-11-oxo-30-norolean-12-en-20-yl]-N'-[(trifluoromethyl)sulfonyl]urea 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 194 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339807&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 53322756 125089909 CHEMBL1689277 ZINC72127038 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629739 C[C@@]1(CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CCC(=O)NC(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)NC(N)=O InChI=1S/C30H47N3O3/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(35)32-25)20(34)16-18-19-17-27(4,33-24(31)36)14-12-26(19,3)13-15-29(18,30)6/h16,19,21,23H,8-15,17H2,1-7H3,(H,32,35)(H3,31,33,36)/t19-,21-,23+,26+,27-,28-,29+,30+/m0/s1 OXEJYJIHFPSCHI-LPXJIFNVSA-N 50339808 CHEMBL1689279::N-[(5aR,7aR,7bS,9aS,12S,13aR,15aR,15bS)-2,3,4,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,15,15a,15b-Eicosahydro-5,5,7a,7b,9a,12,15b-heptamethyl-3,15-dioxo-1H-chryseno[2,1-c]azepine-12-yl]urea 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 33 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339808&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52939228 125089910 CHEMBL1689279 ZINC66112573 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629740 CN(O)C(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CCC(=O)NC(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 InChI=1S/C31H48N2O4/c1-26(2)22-9-12-31(7)24(29(22,5)11-10-23(35)32-26)21(34)17-19-20-18-28(4,25(36)33(8)37)14-13-27(20,3)15-16-30(19,31)6/h17,20,22,24,37H,9-16,18H2,1-8H3,(H,32,35)/t20-,22-,24+,27+,28-,29-,30+,31+/m0/s1 AUQXBLHDEASREV-GJIZTULQSA-N 50339809 (5aR,7aR,7bS,9aS,12S,13aR,15aR,15bS)-2,3,4,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,15,15a,15b-Eicosahydro-5,5,7a,7b,9a,12,15b-heptamethyl-3,15-dioxo-N-hydroxy-N-methyl-1Hchryseno[2,1-c]azepine-12-carboxylic acid amid::CHEMBL1689280 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 11 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339809&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52939227 125089911 CHEMBL1689280 ZINC66112765 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629741 C[C@@]1(CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](Oc6nc(=O)o[nH]6)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)NC(N)=O InChI=1S/C32H48N4O5/c1-27(2)21-8-11-32(7)23(30(21,5)10-9-22(27)40-25-34-26(39)41-36-25)20(37)16-18-19-17-29(4,35-24(33)38)14-12-28(19,3)13-15-31(18,32)6/h16,19,21-23H,8-15,17H2,1-7H3,(H3,33,35,38)(H,34,36,39)/t19-,21-,22-,23+,28+,29-,30-,31+,32+/m0/s1 HOKWINYUFDACLI-UOEOWSRYSA-N 50339810 1-((2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-10-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yloxy)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicen-2-yl)urea::CHEMBL1689281 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339810&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 53322757 125089912 CHEMBL1689281 ZINC66112766 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629742 CN(O)C(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](Oc6nc(=O)o[nH]6)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1 InChI=1S/C33H49N3O6/c1-28(2)22-9-12-33(7)24(31(22,5)11-10-23(28)41-26-34-27(39)42-35-26)21(37)17-19-20-18-30(4,25(38)36(8)40)14-13-29(20,3)15-16-32(19,33)6/h17,20,22-24,40H,9-16,18H2,1-8H3,(H,34,35,39)/t20-,22-,23-,24+,29+,30-,31-,32+,33+/m0/s1 ZBWAJSRMNVFHIR-OAFQVGTHSA-N 50339811 (3beta,18beta,20beta)-N-Hydroxy-N-methyl-[3-(1,2,4-oxadiazole-5(2H)-one)]-11-oxo-olean-12-en-29-amide::CHEMBL1689282 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 15 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339811&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52939229 125089913 CHEMBL1689282 ZINC66112767 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629743 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)NC(N)=O InChI=1S/C30H48N2O3/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)34)20(33)16-18-19-17-27(4,32-24(31)35)14-12-26(19,3)13-15-29(18,30)6/h16,19,21-23,34H,8-15,17H2,1-7H3,(H3,31,32,35)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 CRAONNOIYRTRDB-YKLVYJNSSA-N 50339812 CHEMBL1689283::N-[(3beta,18beta,20beta)-3-Hydroxy-11-oxo-30-norolean-12-en-20-yl]urea 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 17 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339812&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 53326660 125089914 CHEMBL1689283 ZINC66112768 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50629744 C[C@@]1(CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)NC(N)=O InChI=1S/C30H46N2O3/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)34)20(33)16-18-19-17-27(4,32-24(31)35)14-12-26(19,3)13-15-29(18,30)6/h16,19,21,23H,8-15,17H2,1-7H3,(H3,31,32,35)/t19-,21-,23+,26+,27-,28-,29+,30+/m0/s1 OMQVRVGFRSPQIZ-LPXJIFNVSA-N 50339813 CHEMBL1689284::N-[(3beta,18beta,20beta)-3,11-Dioxo-30-norolean-12-en-20-yl]urea 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 45 ChEMBL 10.1016/j.bmc.2011.02.005 10.7270/Q2VD6ZR7 21376605 Gaware, R; Khunt, R; Czollner, L; Stanetty, C; Da Cunha, T; Kratschmar, DV; Odermatt, A; Kosma, P; Jordis, U; Classen-Houben, D University of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339813&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 53326661 125089915 CHEMBL1689284 ZINC66124201 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630847 CCCCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3/c1-3-4-7-10-21-11-14-22(15-12-21,16-13-21)20-28-27-19(29(20)2)17-8-5-6-9-18(17)23(24,25)26/h5-6,8-9H,3-4,7,10-16H2,1-2H3 VPHWCVUMWQOWOK-UHFFFAOYSA-N 50174281 4-methyl-3-(4-pentylbicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL383352 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174281&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10250720 104060099 CHEMBL383352 ZINC28530985 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630848 CC(F)CCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H29F4N3/c1-16(24)6-5-9-21-10-13-22(14-11-21,15-12-21)20-29-28-19(30(20)2)17-7-3-4-8-18(17)23(25,26)27/h3-4,7-8,16H,5-6,9-15H2,1-2H3 ZTWDQFBBGCYGMR-UHFFFAOYSA-N 50340391 3-(4-(4-fluoropentyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761138 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1300 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340391&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586091 131343327 CHEMBL1761138 ZINC71316422 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630849 Cn1c(nnc1C12CCC(CCS(=O)(=O)CC(F)(F)F)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C22H25F6N3O2S/c1-31-17(15-4-2-3-5-16(15)22(26,27)28)29-30-18(31)20-9-6-19(7-10-20,8-11-20)12-13-34(32,33)14-21(23,24)25/h2-5H,6-14H2,1H3 NVNIPOVLJBAUGM-UHFFFAOYSA-N 50340392 4-methyl-3-(4-(2-(2,2,2-trifluoroethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761320 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340392&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583233 131343328 CHEMBL1761320 ZINC71329696 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630852 CC(=O)CCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H28F3N3O/c1-16(30)6-5-9-21-10-13-22(14-11-21,15-12-21)20-28-27-19(29(20)2)17-7-3-4-8-18(17)23(24,25)26/h3-4,7-8H,5-6,9-15H2,1-2H3 JRXYXRZPMZCAIV-UHFFFAOYSA-N 50340394 5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)pentan-2-one::CHEMBL1761137 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340394&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9823394 131343330 CHEMBL1761137 ZINC03960658 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630853 COCCCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O/c1-29-19(17-7-3-4-8-18(17)23(24,25)26)27-28-20(29)22-13-10-21(11-14-22,12-15-22)9-5-6-16-30-2/h3-4,7-8H,5-6,9-16H2,1-2H3 BQIIPZMTXFQIQG-UHFFFAOYSA-N 50340395 3-(4-(4-methoxybutyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761140 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340395&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583210 131343331 CHEMBL1761140 ZINC71319277 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630854 CC(O)CCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O/c1-16(30)6-5-9-21-10-13-22(14-11-21,15-12-21)20-28-27-19(29(20)2)17-7-3-4-8-18(17)23(24,25)26/h3-4,7-8,16,30H,5-6,9-15H2,1-2H3 LWSUXLRGYIUHPP-UHFFFAOYSA-N 50340396 5-(4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)pentan-2-ol::CHEMBL1761136 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340396&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20755103 131343332 CHEMBL1761136 ZINC71319263 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630889 Cn1c(nnc1C12CCC(CCCC(C)(F)F)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C23H28F5N3/c1-20(24,25)8-5-9-21-10-13-22(14-11-21,15-12-21)19-30-29-18(31(19)2)16-6-3-4-7-17(16)23(26,27)28/h3-4,6-7H,5,8-15H2,1-2H3 RJDVDAPIQXMABK-UHFFFAOYSA-N 50340397 3-(4-(4,4-difluoropentyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761139 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340397&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582242 131343333 CHEMBL1761139 ZINC71329214 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630890 CCOCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C21H26F3N3O/c1-3-28-14-19-8-11-20(12-9-19,13-10-19)18-26-25-17(27(18)2)15-6-4-5-7-16(15)21(22,23)24/h4-7H,3,8-14H2,1-2H3 QAWPXQQBJVQBKE-UHFFFAOYSA-N 50340398 3-(4-(ethoxymethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761141 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340398&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54580210 131343334 CHEMBL1761141 ZINC71329566 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630891 Cn1c(nnc1C12CCC(COc3ccc(cc3)S(C)(=O)=O)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C26H28F3N3O3S/c1-32-22(20-5-3-4-6-21(20)26(27,28)29)30-31-23(32)25-14-11-24(12-15-25,13-16-25)17-35-18-7-9-19(10-8-18)36(2,33)34/h3-10H,11-17H2,1-2H3 MUQZDSVVZOGCQZ-UHFFFAOYSA-N 50340399 4-methyl-3-(4-((4-(methylsulfonyl)phenoxy)methyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761143 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340399&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54586092 131343335 CHEMBL1761143 ZINC71315866 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630892 Cn1c(nnc1C12CCC(CNS(C)(=O)=O)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C20H25F3N4O2S/c1-27-16(14-5-3-4-6-15(14)20(21,22)23)25-26-17(27)19-10-7-18(8-11-19,9-12-19)13-24-30(2,28)29/h3-6,24H,7-13H2,1-2H3 DFILCFKLBRQIOI-UHFFFAOYSA-N 50340387 CHEMBL1761144::N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)methanesulfonamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340387&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54581213 131343323 CHEMBL1761144 ZINC71296922 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630893 CCS(=O)(=O)NCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C21H27F3N4O2S/c1-3-31(29,30)25-14-19-8-11-20(12-9-19,13-10-19)18-27-26-17(28(18)2)15-6-4-5-7-16(15)21(22,23)24/h4-7,25H,3,8-14H2,1-2H3 BOZUAKRAAYEOLG-UHFFFAOYSA-N 50340384 CHEMBL1761309::N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)ethanesulfonamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340384&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584196 131343320 CHEMBL1761309 ZINC71329581 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630894 CCCS(=O)(=O)NCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C22H29F3N4O2S/c1-3-14-32(30,31)26-15-20-8-11-21(12-9-20,13-10-20)19-28-27-18(29(19)2)16-6-4-5-7-17(16)22(23,24)25/h4-7,26H,3,8-15H2,1-2H3 CLPWJRQJAHLUQT-UHFFFAOYSA-N 50340380 CHEMBL1761310::N-((4-(4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)propane-1-sulfonamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340380&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54582261 131343316 CHEMBL1761310 ZINC71317763 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630895 CCSCCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C22H28F3N3S/c1-3-29-15-14-20-8-11-21(12-9-20,13-10-20)19-27-26-18(28(19)2)16-6-4-5-7-17(16)22(23,24)25/h4-7H,3,8-15H2,1-2H3 UAYZIYYBLXQLES-UHFFFAOYSA-N 50340400 3-(4-(2-(ethylthio)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761311 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340400&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587121 131343336 CHEMBL1761311 ZINC71330906 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630896 CCS(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C22H28F3N3OS/c1-3-30(29)15-14-20-8-11-21(12-9-20,13-10-20)19-27-26-18(28(19)2)16-6-4-5-7-17(16)22(23,24)25/h4-7H,3,8-15H2,1-2H3 HDJZSGDARWVVJV-UHFFFAOYSA-N 50340371 3-(4-(2-(ethylsulfinyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761312 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340371&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584197 131343307 CHEMBL1761312 ZINC71330779 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630897 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C22H28F3N3O2S/c1-3-31(29,30)15-14-20-8-11-21(12-9-20,13-10-20)19-27-26-18(28(19)2)16-6-4-5-7-17(16)22(23,24)25/h4-7H,3,8-15H2,1-2H3 ZQPJDHAUCVEXLU-UHFFFAOYSA-N 50340378 3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761313 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340378&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 22591709 131343314 CHEMBL1761313 ZINC43128373 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630898 Cn1c(nnc1C12CCC(CCS(C)(=O)=O)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C21H26F3N3O2S/c1-27-17(15-5-3-4-6-16(15)21(22,23)24)25-26-18(27)20-10-7-19(8-11-20,9-12-20)13-14-30(2,28)29/h3-6H,7-14H2,1-2H3 FZVYZFRWYBAMAX-UHFFFAOYSA-N 50340382 4-methyl-3-(4-(2-(methylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761314 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340382&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583231 131343318 CHEMBL1761314 ZINC71330669 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630899 CCCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O2S/c1-3-15-32(30,31)16-14-21-8-11-22(12-9-21,13-10-21)20-28-27-19(29(20)2)17-6-4-5-7-18(17)23(24,25)26/h4-7H,3,8-16H2,1-2H3 ZRWCLFICBXDDJY-UHFFFAOYSA-N 50340374 4-methyl-3-(4-(2-(propylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761315 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340374&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54587122 131343310 CHEMBL1761315 ZINC71316649 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630900 CC(C)S(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C23H30F3N3O2S/c1-16(2)32(30,31)15-14-21-8-11-22(12-9-21,13-10-21)20-28-27-19(29(20)3)17-6-4-5-7-18(17)23(24,25)26/h4-7,16H,8-15H2,1-3H3 KGLIHOPUIXJEHX-UHFFFAOYSA-N 50340372 3-(4-(2-(isopropylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761316 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340372&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20755069 131343308 CHEMBL1761316 ZINC71329549 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630901 Cn1c(nnc1C12CCC(CCS(=O)(=O)C(C)(C)C)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C24H32F3N3O2S/c1-21(2,3)33(31,32)16-15-22-9-12-23(13-10-22,14-11-22)20-29-28-19(30(20)4)17-7-5-6-8-18(17)24(25,26)27/h5-8H,9-16H2,1-4H3 GHISAKGSVUVTIE-UHFFFAOYSA-N 50340375 3-(4-(2-(tert-butylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761317 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340375&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44197230 131343311 CHEMBL1761317 ZINC71330921 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630902 Cn1c(nnc1C12CCC(CCS(=O)(=O)c3ccccc3)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C26H28F3N3O2S/c1-32-22(20-9-5-6-10-21(20)26(27,28)29)30-31-23(32)25-14-11-24(12-15-25,13-16-25)17-18-35(33,34)19-7-3-2-4-8-19/h2-10H,11-18H2,1H3 JBDITXLBFFQSTN-UHFFFAOYSA-N 50340373 4-methyl-3-(4-(2-(phenylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761318 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340373&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54583232 131343309 CHEMBL1761318 ZINC71316719 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630903 Cn1c(nnc1C12CCC(CCS(=O)(=O)c3ccc(F)cc3)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C26H27F4N3O2S/c1-33-22(20-4-2-3-5-21(20)26(28,29)30)31-32-23(33)25-13-10-24(11-14-25,12-15-25)16-17-36(34,35)19-8-6-18(27)7-9-19/h2-9H,10-17H2,1H3 MVGZKTAXQNUWOV-UHFFFAOYSA-N 50340376 3-(4-(2-(4-fluorophenylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1760014 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340376&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 54584415 131343312 CHEMBL1760014 ZINC71316288 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50630904 Cn1c(nnc1C12CCC(CCS(=O)(=O)C(F)(F)F)(CC1)CC2)-c1ccccc1C(F)(F)F InChI=1S/C21H23F6N3O2S/c1-30-16(14-4-2-3-5-15(14)20(22,23)24)28-29-17(30)19-9-6-18(7-10-19,8-11-19)12-13-33(31,32)21(25,26)27/h2-5H,6-13H2,1H3 SYOUVVMHXMQLMO-UHFFFAOYSA-N 50340377 4-methyl-3-(2-(trifluoromethyl)phenyl)-5-(4-(2-(trifluoromethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4H-1,2,4-triazole::CHEMBL1761319 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2011.01.018 10.7270/Q2QJ7HMK 21421311 Maletic, M; Leeman, A; Szymonifka, M; Mundt, SS; Zokian, HJ; Shah, K; Dragovic, J; Lyons, K; Thieringer, R; Vosatka, AH; Balkovec, J; Waddell, ST Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340377&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 22591726 131343313 CHEMBL1761319 ZINC71315953 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50661443 C[C@H](N1CC[C@@](CCO)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(F)cc1F InChI=1S/C26H24F3NO3/c1-17(18-2-4-19(5-3-18)23-11-10-22(28)16-24(23)29)30-14-12-26(13-15-31,33-25(30)32)20-6-8-21(27)9-7-20/h2-11,16-17,31H,12-15H2,1H3/t17-,26-/m0/s1 SLSMHOGJKAPYQU-QLXKLKPCSA-N 50353386 CHEMBL1829763::US8592410, 88::US8592410, Comparator 3::US8598163, 61 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm2005354 10.7270/Q2P26ZH3 21786805 Xu, Z; Tice, CM; Zhao, W; Cacatian, S; Ye, YJ; Singh, SB; Lindblom, P; McKeever, BM; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JA; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Togias, J; Guo, J; Guo, R; Carroll, PJ; McGeehan, GM; Zhuang, L; He, W; Claremon, DA Vitae Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50353386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50353386&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 53361128 136360072 CHEMBL1829763 ZINC72117035 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50664220 O=C(CSc1nnc(-c2ccccc2)c(n1)-c1ccccc1)N1CCc2ccccc12 InChI=1S/C25H20N4OS/c30-22(29-16-15-18-9-7-8-14-21(18)29)17-31-25-26-23(19-10-3-1-4-11-19)24(27-28-25)20-12-5-2-6-13-20/h1-14H,15-17H2 VYWVGJDFMVEDFJ-UHFFFAOYSA-N 72094 1-(2,3-Dihydro-indol-1-yl)-2-(5,6-diphenyl-[1,2,4]triazin-3-ylsulfanyl)-ethanone::1-(2,3-dihydroindol-1-yl)-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)sulfanyl]ethanone::1-(2,3-dihydroindol-1-yl)-2-[(5,6-diphenyl-1,2,4-triazin-3-yl)thio]ethanone::2-[(5,6-diphenyl-1,2,4-triazin-3-yl)thio]-1-indolin-1-yl-ethanone::MLS000550742::SMR000177935::cid_3146235 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 8900 ChEMBL 10.1016/j.bmcl.2011.08.019 10.7270/Q27H1K0C 21873057 Xia, G; Xue, M; Liu, L; Yu, J; Liu, H; Li, P; Wang, J; Li, Y; Xiong, B; Shen, J Shanghai Pharmaceutical Holding Co. Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=72094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=72094&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3146235 252649359 ZINC00904743 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50649178 Cc1c(Cl)cccc1Oc1cccn2c(nnc12)C12CCC(O)(CC1)CC2 InChI=1S/C21H22ClN3O2/c1-14-15(22)4-2-5-16(14)27-17-6-3-13-25-18(17)23-24-19(25)20-7-10-21(26,11-8-20)12-9-20/h2-6,13,26H,7-12H2,1H3 BAGSDLHAZBBSOF-UHFFFAOYSA-N 50348309 CHEMBL1800134 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2520 ChEMBL 10.1016/j.bmcl.2011.05.101 10.7270/Q24F1R2Q 21689935 Wang, H; Robl, JA; Hamann, LG; Simpkins, L; Golla, R; Li, YX; Seethala, R; Zvyaga, T; Gordon, DA; Li, JJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50348309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50348309&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 15953464 136354995 CHEMBL1800134 ZINC34808900 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50708005 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)O[C@@H]1O[C@@H]([C@@H](O)[C@H](O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)[C@H]1O)C(O)=O InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-27(48)28(26(47)30(58-35)33(51)52)56-34-25(46)23(44)24(45)29(57-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25+,26-,27+,28-,29-,30-,31+,34+,35+,38+,39-,40-,41+,42+/m0/s1 KEIFOIQHFNUSQE-HDENPQJWSA-N 50359991 CHEMBL1927953 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 0.7 ChEMBL 10.1021/np200755t 10.7270/Q2P26ZJJ 22148241 Han, J; Ji, CJ; He, WJ; Shen, Y; Leng, Y; Xu, WY; Fan, JT; Zeng, GZ; Kong, LD; Tan, NH Kunming Institute of Botany http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50359991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50359991&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 21124245 136964015 CHEMBL1927953 C03033 ZINC96178998 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50699923 O=c1[nH]c(SCc2ccccc2)c2CCc3ccccc3-c2c1C#N InChI=1S/C21H16N2OS/c22-12-18-19-16-9-5-4-8-15(16)10-11-17(19)21(23-20(18)24)25-13-14-6-2-1-3-7-14/h1-9H,10-11,13H2,(H,23,24) QVUNFYOXAPUVEZ-UHFFFAOYSA-N 50356448 CHEMBL1911698 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 386 ChEMBL 10.1016/j.bmcl.2011.09.058 10.7270/Q2FN16M4 21983444 Wu, SC; Yoon, D; Chin, J; van Kirk, K; Seethala, R; Golla, R; He, B; Harrity, T; Kunselman, LK; Morgan, NN; Ponticiello, RP; Taylor, JR; Zebo, R; Harper, TW; Li, W; Wang, M; Zhang, L; Sleczka, BG; Nayeem, A; Sheriff, S; Camac, DM; Morin, PE; Everlof, JG; Li, YX; Ferraro, CA; Kieltyka, K; Shou, W; Vath, MB; Zvyaga, TA; Gordon, DA; Robl, JA Bristol-Myers Squibb Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50356448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50356448&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57392785 136960472 CHEMBL1911698 ZINC73160355 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50850880 FC(F)(F)c1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1 InChI=1S/C15H11F3O3S/c16-15(17,18)12-8-6-11(7-9-12)14(19)10-22(20,21)13-4-2-1-3-5-13/h1-9H,10H2 PDXUGNITDTZZFN-UHFFFAOYSA-N 50167718 2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethanone::2-Benzenesulfonyl-1-(4-trifluoromethyl-phenyl)-ethanone::CHEMBL383146 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmc.2007.04.035 10.7270/Q24M95CG 17490884 Xiang, J; Ipek, M; Suri, V; Tam, M; Xing, Y; Huang, N; Zhang, Y; Tobin, J; Mansour, TS; McKew, J Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50167718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50167718&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11232699 104052934 CHEMBL383146 ZINC13981551 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50850893 Clc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1 InChI=1S/C14H11ClO3S/c15-12-8-6-11(7-9-12)14(16)10-19(17,18)13-4-2-1-3-5-13/h1-9H,10H2 KZACHGLUJYSTGQ-UHFFFAOYSA-N 50212531 1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone::CHEMBL238834 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmc.2007.04.035 10.7270/Q24M95CG 17490884 Xiang, J; Ipek, M; Suri, V; Tam, M; Xing, Y; Huang, N; Zhang, Y; Tobin, J; Mansour, TS; McKew, J Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212531&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 586971 104088405 CHEMBL238834 ZINC00058239 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50850894 COc1cccc(c1)C(=O)CS(=O)(=O)c1ccccc1 InChI=1S/C15H14O4S/c1-19-13-7-5-6-12(10-13)15(16)11-20(17,18)14-8-3-2-4-9-14/h2-10H,11H2,1H3 HHEJEAZSXBXRPO-UHFFFAOYSA-N 50212534 1-(3-methoxyphenyl)-2-(phenylsulfonyl)ethanone::CHEMBL393079 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmc.2007.04.035 10.7270/Q24M95CG 17490884 Xiang, J; Ipek, M; Suri, V; Tam, M; Xing, Y; Huang, N; Zhang, Y; Tobin, J; Mansour, TS; McKew, J Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212534&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 16750524 104088408 CHEMBL393079 ZINC28874643 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50850895 COc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1 InChI=1S/C15H14O4S/c1-19-13-9-7-12(8-10-13)15(16)11-20(17,18)14-5-3-2-4-6-14/h2-10H,11H2,1H3 ZVVAUSXHYOKZSR-UHFFFAOYSA-N 50212535 1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethanone::CHEMBL238620 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmc.2007.04.035 10.7270/Q24M95CG 17490884 Xiang, J; Ipek, M; Suri, V; Tam, M; Xing, Y; Huang, N; Zhang, Y; Tobin, J; Mansour, TS; McKew, J Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212535&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 4271571 104088409 CHEMBL238620 ZINC00399878 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50850899 Fc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1 InChI=1S/C14H11FO3S/c15-12-8-6-11(7-9-12)14(16)10-19(17,18)13-4-2-1-3-5-13/h1-9H,10H2 FCXNRTNBPQUTBL-UHFFFAOYSA-N 50212525 1-(4-fluorophenyl)-2-(phenylsulfonyl)ethanone::CHEMBL238832 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmc.2007.04.035 10.7270/Q24M95CG 17490884 Xiang, J; Ipek, M; Suri, V; Tam, M; Xing, Y; Huang, N; Zhang, Y; Tobin, J; Mansour, TS; McKew, J Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212525&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 1483401 104088399 CHEMBL238832 ZINC01396918 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50850901 CCN(CC)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1 InChI=1S/C16H20ClN3O3S2/c1-4-20(5-2)15(21)9-12-10-24-16(18-12)19-25(22,23)14-8-6-7-13(17)11(14)3/h6-8,10H,4-5,9H2,1-3H3,(H,18,19) PNFMZAHWOASGJC-UHFFFAOYSA-N 50117901 2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide::2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thiazol-4-yl]-N,N-diethyl-acetamide::2-[2-(3-Chloro-2-methyl-benzenesulfonylamino)-thiazol-4-yl]-N,N-diethyl-acetamide (BVT.14225)::BVT-14225::CHEMBL341324 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmc.2007.04.035 10.7270/Q24M95CG 17490884 Xiang, J; Ipek, M; Suri, V; Tam, M; Xing, Y; Huang, N; Zhang, Y; Tobin, J; Mansour, TS; McKew, J Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50117901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50117901&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 6918663 104011312 CHEMBL341324 ZINC00595364 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50850906 Cc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1 InChI=1S/C15H14O3S/c1-12-7-9-13(10-8-12)15(16)11-19(17,18)14-5-3-2-4-6-14/h2-10H,11H2,1H3 DITVWQPTRBYVRP-UHFFFAOYSA-N 50212530 2-(phenylsulfonyl)-1-p-tolylethanone::CHEMBL392808 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >200000 ChEMBL 10.1016/j.bmc.2007.04.035 10.7270/Q24M95CG 17490884 Xiang, J; Ipek, M; Suri, V; Tam, M; Xing, Y; Huang, N; Zhang, Y; Tobin, J; Mansour, TS; McKew, J Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212530&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 15627039 104088404 CHEMBL392808 ZINC28874639 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870134 Cn1c(nnc1C12CC3CC(CC(C3)C1)C2)-c1ccccc1 InChI=1S/C19H23N3/c1-22-17(16-5-3-2-4-6-16)20-21-18(22)19-10-13-7-14(11-19)9-15(8-13)12-19/h2-6,13-15H,7-12H2,1H3 SPLKSRDVCTUAGF-UHFFFAOYSA-N 50239276 3-Adamantan-1-yl-4-methyl-5-phenyl-4H-[1,2,4]triazole::CHEMBL428429 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.010 10.7270/Q2J9678F 18434143 Aster, SD; Graham, DW; Kharbanda, D; Patel, G; Ponpipom, M; Santorelli, GM; Szymonifka, MJ; Mundt, SS; Shah, K; Springer, MS; Thieringer, R; Hermanowski-Vosatka, A; Wright, SD; Xiao, J; Zokian, H; Balkovec, JM Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239276&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10193044 104056504 CHEMBL428429 ZINC13984397 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50874978 C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@H](F)CC1)C(F)(F)F InChI=1S/C19H23F4NO2/c1-18(26,19(21,22)23)13-4-2-12(3-5-13)17(25)24(16-10-11-16)15-8-6-14(20)7-9-15/h2-5,14-16,26H,6-11H2,1H3/t14-,15-,18-/m0/s1 MCQZOJFPSRKRQW-MPGHIAIKSA-N 50243671 (S)-N-(trans-4-Fluorocyclohexyl)-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide::CHEMBL471930 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm800310g 10.7270/Q2P84CSZ 18553955 Julian, LD; Wang, Z; Bostick, T; Caille, S; Choi, R; DeGraffenreid, M; Di, Y; He, X; Hungate, RW; Jaen, JC; Liu, J; Monshouwer, M; McMinn, D; Rew, Y; Sudom, A; Sun, D; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50243671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50243671&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 15987476 104099909 CHEMBL471930 ZINC34854202 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50874979 C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@H](CCC#N)CC1)C(F)(F)F InChI=1S/C22H27F3N2O2/c1-21(29,22(23,24)25)17-8-6-16(7-9-17)20(28)27(19-12-13-19)18-10-4-15(5-11-18)3-2-14-26/h6-9,15,18-19,29H,2-5,10-13H2,1H3/t15-,18-,21-/m0/s1 IHSUMNRQVFTRRP-XERREHJYSA-N 28365 CHEMBL512355::N-[4-(2-cyanoethyl)cyclohexyl]-N-cyclopropyl-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide::cyclohexyl benzamide derivative, 4 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm800310g 10.7270/Q2P84CSZ 18553955 Julian, LD; Wang, Z; Bostick, T; Caille, S; Choi, R; DeGraffenreid, M; Di, Y; He, X; Hungate, RW; Jaen, JC; Liu, J; Monshouwer, M; McMinn, D; Rew, Y; Sudom, A; Sun, D; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28365&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 15987396 58097554 CHEMBL512355 ZINC34854056 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50874980 C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@H](CC1)c1cccnc1)C(F)(F)F InChI=1S/C24H27F3N2O2/c1-23(31,24(25,26)27)19-8-4-17(5-9-19)22(30)29(21-12-13-21)20-10-6-16(7-11-20)18-3-2-14-28-15-18/h2-5,8-9,14-16,20-21,31H,6-7,10-13H2,1H3/t16-,20-,23-/m0/s1 FLRYWTWLHWACRP-GRWTVWFQSA-N 28361 N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2S)-1,1,1-trifluoro-2-hydroxypropan-2-yl]benzamide::cyclohexyl benzamide derivative, 1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm800310g 10.7270/Q2P84CSZ 18553955 Julian, LD; Wang, Z; Bostick, T; Caille, S; Choi, R; DeGraffenreid, M; Di, Y; He, X; Hungate, RW; Jaen, JC; Liu, J; Monshouwer, M; McMinn, D; Rew, Y; Sudom, A; Sun, D; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28361&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search D3E 16726072 58097550 DB07619 ZINC39109886 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50874981 C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@H](CC1)c1ccc(cc1)C#N)C(F)(F)F InChI=1S/C26H27F3N2O2/c1-25(33,26(27,28)29)21-10-6-20(7-11-21)24(32)31(23-14-15-23)22-12-8-19(9-13-22)18-4-2-17(16-30)3-5-18/h2-7,10-11,19,22-23,33H,8-9,12-15H2,1H3/t19-,22-,25-/m0/s1 XRRFWTVWZPSRQE-JTJYXVOQSA-N 50243635 (S)-N-[trans-4-(4-Cyanophenyl)cyclohexyl]-4-[1,1,1-trifluoro-2-hydroxypropan-2-yl]-N-cyclopropylbenzamide::CHEMBL511828::N-((1r,4S)-4-(4-cyanophenyl)cyclohexyl)-N-cyclopropyl-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm800310g 10.7270/Q2P84CSZ 18553955 Julian, LD; Wang, Z; Bostick, T; Caille, S; Choi, R; DeGraffenreid, M; Di, Y; He, X; Hungate, RW; Jaen, JC; Liu, J; Monshouwer, M; McMinn, D; Rew, Y; Sudom, A; Sun, D; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50243635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50243635&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24895658 104099880 CHEMBL511828 ZINC40873093 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50874982 C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)c1ccccc1)C(F)(F)F InChI=1S/C25H28F3NO2/c1-24(31,25(26,27)28)20-11-7-19(8-12-20)23(30)29(22-15-16-22)21-13-9-18(10-14-21)17-5-3-2-4-6-17/h2-8,11-12,18,21-22,31H,9-10,13-16H2,1H3/t18-,21+,24-/m0/s1 GBXSZYKBVSEFOW-VNZMSGEBSA-N 50243634 (S)-N-(cis-4-Phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide::CHEMBL471750 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm800310g 10.7270/Q2P84CSZ 18553955 Julian, LD; Wang, Z; Bostick, T; Caille, S; Choi, R; DeGraffenreid, M; Di, Y; He, X; Hungate, RW; Jaen, JC; Liu, J; Monshouwer, M; McMinn, D; Rew, Y; Sudom, A; Sun, D; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50243634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50243634&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24895554 104099879 CHEMBL471750 ZINC40406342 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50874983 C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)[C@H]1CC[C@@H](CC1)c1ccccc1)C(F)(F)F InChI=1S/C25H28F3NO2/c1-24(31,25(26,27)28)20-11-7-19(8-12-20)23(30)29(22-15-16-22)21-13-9-18(10-14-21)17-5-3-2-4-6-17/h2-8,11-12,18,21-22,31H,9-10,13-16H2,1H3/t18-,21-,24-/m0/s1 GBXSZYKBVSEFOW-XZOYJPPVSA-N 50243633 (S)-N-(trans-4-Phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide::CHEMBL469699::N-cyclopropyl-N-((1r,4S)-4-phenylcyclohexyl)-4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)benzamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm800310g 10.7270/Q2P84CSZ 18553955 Julian, LD; Wang, Z; Bostick, T; Caille, S; Choi, R; DeGraffenreid, M; Di, Y; He, X; Hungate, RW; Jaen, JC; Liu, J; Monshouwer, M; McMinn, D; Rew, Y; Sudom, A; Sun, D; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50243633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50243633&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24895554 104099878 CHEMBL469699 ZINC40406342 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50875002 C[C@](O)(c1ccc(cc1)C(=O)N(C1CC1)C1CCCCC1)C(F)(F)F InChI=1S/C19H24F3NO2/c1-18(25,19(20,21)22)14-9-7-13(8-10-14)17(24)23(16-11-12-16)15-5-3-2-4-6-15/h7-10,15-16,25H,2-6,11-12H2,1H3/t18-/m0/s1 MMIDZOVIJQHNLX-SFHVURJKSA-N 50243632 (S)-N-Cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide::CHEMBL469698 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/jm800310g 10.7270/Q2P84CSZ 18553955 Julian, LD; Wang, Z; Bostick, T; Caille, S; Choi, R; DeGraffenreid, M; Di, Y; He, X; Hungate, RW; Jaen, JC; Liu, J; Monshouwer, M; McMinn, D; Rew, Y; Sudom, A; Sun, D; Tu, H; Ursu, S; Walker, N; Yan, X; Ye, Q; Powers, JP Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50243632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50243632&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24895661 104099877 CHEMBL469698 ZINC34853892 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870404 C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCn12 InChI=1S/C17H25N3/c1-2-4-15-18-19-16(20(15)5-3-1)17-9-12-6-13(10-17)8-14(7-12)11-17/h12-14H,1-11H2 VFTQRHWULYJKCI-UHFFFAOYSA-N 50239401 3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine::CHEMBL256777::MERCK-544 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >3000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3630776 104056507 CHEMBL256777 ZINC05494877 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870407 C1CCC(CC1)(c1nnc2CCCCCCn12)c1ccccc1 InChI=1S/C20H27N3/c1-2-10-16-23-18(13-7-1)21-22-19(23)20(14-8-4-9-15-20)17-11-5-3-6-12-17/h3,5-6,11-12H,1-2,4,7-10,13-16H2 DFFWGGJNBZJCEH-UHFFFAOYSA-N 50377877 CHEMBL256571 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1037 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377877&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10403095 160856960 CHEMBL256571 ZINC29045258 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870417 FC1(F)CC(C1)(c1nnc(C2CC2)n1C1CC1)c1ccc(Cl)cc1 InChI=1S/C18H18ClF2N3/c19-13-5-3-12(4-6-13)17(9-18(20,21)10-17)16-23-22-15(11-1-2-11)24(16)14-7-8-14/h3-6,11,14H,1-2,7-10H2 CNSHOXCOEFBECD-UHFFFAOYSA-N 50377889 CHEMBL255260 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377889&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44448872 160856972 CHEMBL255260 ZINC29044277 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870418 F[C@H]1C[C@](C1)(c1nnc(C2CC2)n1C1CC1)c1ccc(Cl)cc1 InChI=1S/C18H19ClFN3/c19-13-5-3-12(4-6-13)18(9-14(20)10-18)17-22-21-16(11-1-2-11)23(17)15-7-8-15/h3-6,11,14-15H,1-2,7-10H2/t14-,18+ OGYZYOKAXYFLIU-UJKQEGAGSA-N 50377887 CHEMBL255259 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377887&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9797661 160856970 CHEMBL255259 ZINC03928057 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870419 F[C@H]1C[C@@](C1)(c1nnc(C2CC2)n1C1CC1)c1ccc(Cl)cc1 InChI=1S/C18H19ClFN3/c19-13-5-3-12(4-6-13)18(9-14(20)10-18)17-22-21-16(11-1-2-11)23(17)15-7-8-15/h3-6,11,14-15H,1-2,7-10H2/t14-,18- OGYZYOKAXYFLIU-PPUGGXLSSA-N 50377888 CHEMBL404095 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377888&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9797661 160856971 CHEMBL404095 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870448 Clc1ccc(c(Cl)c1)C1(CC1)c1nnc2CCCCCCn12 InChI=1S/C17H19Cl2N3/c18-12-6-7-13(14(19)11-12)17(8-9-17)16-21-20-15-5-3-1-2-4-10-22(15)16/h6-7,11H,1-5,8-10H2 RQEHKNLHGDPXDS-UHFFFAOYSA-N 50377884 CHEMBL403993 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1964 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377884&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11724534 160856967 CHEMBL403993 ZINC29044283 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870449 Cc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H25N3/c1-15-8-10-16(11-9-15)19(12-6-13-19)18-21-20-17-7-4-2-3-5-14-22(17)18/h8-11H,2-7,12-14H2,1H3 DIPILFAQLQBGGN-UHFFFAOYSA-N 50377865 CHEMBL404435 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2006 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377865&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10040176 160856948 CHEMBL404435 ZINC29044649 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870450 Cc1ccccc1C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H25N3/c1-15-9-5-6-10-16(15)19(12-8-13-19)18-21-20-17-11-4-2-3-7-14-22(17)18/h5-6,9-10H,2-4,7-8,11-14H2,1H3 UUUYGEMUTWIEJT-UHFFFAOYSA-N 50377880 CHEMBL404436 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3318 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377880&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10040175 160856963 CHEMBL404436 ZINC29044655 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870451 Cc1ccc(cc1)C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C20H27N3/c1-16-9-11-17(12-10-16)20(13-5-6-14-20)19-22-21-18-8-4-2-3-7-15-23(18)19/h9-12H,2-8,13-15H2,1H3 QCBITCMHMMZFGC-UHFFFAOYSA-N 50377870 CHEMBL256515 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 503 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377870&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10357992 160856953 CHEMBL256515 ZINC29044808 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870452 Cc1cccc(c1)C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C20H27N3/c1-16-9-8-10-17(15-16)20(12-5-6-13-20)19-22-21-18-11-4-2-3-7-14-23(18)19/h8-10,15H,2-7,11-14H2,1H3 DTJZINRCDGOYGP-UHFFFAOYSA-N 50377882 CHEMBL255934 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1961 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377882&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11722880 160856965 CHEMBL255934 ZINC29044963 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870453 Fc1ccccc1C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C19H24FN3/c20-16-10-5-4-9-15(16)19(12-6-7-13-19)18-22-21-17-11-3-1-2-8-14-23(17)18/h4-5,9-10H,1-3,6-8,11-14H2 GEQGACGSKOJYFR-UHFFFAOYSA-N 50377883 CHEMBL256291 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1270 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377883&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10018475 160856966 CHEMBL256291 ZINC29045109 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870454 C1CCC(C1)(c1nnc2CCCCCCn12)c1ccccc1 InChI=1S/C19H25N3/c1-2-9-15-22-17(12-6-1)20-21-18(22)19(13-7-8-14-19)16-10-4-3-5-11-16/h3-5,10-11H,1-2,6-9,12-15H2 SRTPHHCUWHWGSZ-UHFFFAOYSA-N 50377874 CHEMBL402386 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1035 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377874&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10085885 160856957 CHEMBL402386 ZINC29045106 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870455 Cc1ccc(cc1)C1(CCCCC1)c1nnc2CCCCCCn12 InChI=1S/C21H29N3/c1-17-10-12-18(13-11-17)21(14-6-4-7-15-21)20-23-22-19-9-5-2-3-8-16-24(19)20/h10-13H,2-9,14-16H2,1H3 IMHUBBHLFGUOQY-UHFFFAOYSA-N 50377875 CHEMBL256090 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 216 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377875&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10381554 160856958 CHEMBL256090 ZINC29045104 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870456 Clc1ccc(cc1)C1(CCCCC1)c1nnc2CCCCCCn12 InChI=1S/C20H26ClN3/c21-17-11-9-16(10-12-17)20(13-5-3-6-14-20)19-23-22-18-8-4-1-2-7-15-24(18)19/h9-12H,1-8,13-15H2 NWLFUNAYJKKBKR-UHFFFAOYSA-N 50377876 CHEMBL256292 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 613 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377876&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10360107 160856959 CHEMBL256292 ZINC29045115 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870457 Fc1ccc(cc1)C1(CCCCC1)c1nnc2CCCCCCn12 InChI=1S/C20H26FN3/c21-17-11-9-16(10-12-17)20(13-5-3-6-14-20)19-23-22-18-8-4-1-2-7-15-24(18)19/h9-12H,1-8,13-15H2 LGWPMKUAOWIERK-UHFFFAOYSA-N 50377890 CHEMBL402387 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1174 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377890&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 20724870 160856973 CHEMBL402387 ZINC29045112 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870458 Fc1ccc(cc1)C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C19H24FN3/c20-16-10-8-15(9-11-16)19(12-4-5-13-19)18-22-21-17-7-3-1-2-6-14-23(17)18/h8-11H,1-7,12-14H2 XGTBDMONMCJFFG-UHFFFAOYSA-N 50377873 CHEMBL402613 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377873&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10064183 160856956 CHEMBL402613 ZINC29044968 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870459 Cc1ccc(cc1)C1(CC1)c1nnc2CCCCCCn12 InChI=1S/C18H23N3/c1-14-7-9-15(10-8-14)18(11-12-18)17-20-19-16-6-4-2-3-5-13-21(16)17/h7-10H,2-6,11-13H2,1H3 XPVLBRLPRNDVHD-UHFFFAOYSA-N 50377878 CHEMBL258447 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377878&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10446475 160856961 CHEMBL258447 ZINC29044472 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870460 Clc1ccc(cc1)C1(CC1)c1nnc2CCCCCCn12 InChI=1S/C17H20ClN3/c18-14-8-6-13(7-9-14)17(10-11-17)16-20-19-15-5-3-1-2-4-12-21(15)16/h6-9H,1-5,10-12H2 RWLLTYVPGSHWBD-UHFFFAOYSA-N 50377886 CHEMBL258446 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377886&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10357519 160856969 CHEMBL258446 ZINC29044469 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870461 C1CC1(c1nnc2CCCCCCn12)c1ccccc1 InChI=1S/C17H21N3/c1-2-7-13-20-15(10-6-1)18-19-16(20)17(11-12-17)14-8-4-3-5-9-14/h3-5,8-9H,1-2,6-7,10-13H2 OFULOUJEJXONJP-UHFFFAOYSA-N 50377885 CHEMBL402995 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377885&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10355633 160856968 CHEMBL402995 ZINC29044479 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870462 FC(F)(F)c1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H22F3N3/c20-19(21,22)15-9-7-14(8-10-15)18(11-5-12-18)17-24-23-16-6-3-1-2-4-13-25(16)17/h7-10H,1-6,11-13H2 BPNAZBBPOPSBMO-UHFFFAOYSA-N 50377864 CHEMBL403201 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377864&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 9975108 160856947 CHEMBL403201 ZINC29044475 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870463 FC(F)(F)c1ccccc1C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H22F3N3/c20-19(21,22)15-9-5-4-8-14(15)18(11-7-12-18)17-24-23-16-10-3-1-2-6-13-25(16)17/h4-5,8-9H,1-3,6-7,10-13H2 BHGXJGPTKFVTMQ-UHFFFAOYSA-N 50377879 CHEMBL258448 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377879&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10043410 160856962 CHEMBL258448 ZINC29044476 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870464 Cc1cccc(c1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C19H25N3/c1-15-8-6-9-16(14-15)19(11-7-12-19)18-21-20-17-10-4-2-3-5-13-22(17)18/h6,8-9,14H,2-5,7,10-13H2,1H3 XSXASYVDBXMZSI-UHFFFAOYSA-N 50377866 CHEMBL257148 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377866&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10402262 160856949 CHEMBL257148 ZINC29044658 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870465 Clc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22ClN3/c19-15-9-7-14(8-10-15)18(11-5-12-18)17-21-20-16-6-3-1-2-4-13-22(16)17/h7-10H,1-6,11-13H2 FDLFGCPTRMXATH-UHFFFAOYSA-N 50239407 3-(1-(4-chlorophenyl)cyclobutyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::3-[1-(4-Chloro-phenyl)-cyclobutyl]-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a]azocine::CHEMBL257149 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239407&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10335880 104056508 CHEMBL257149 ZINC29044661 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870466 Fc1ccc(cc1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22FN3/c19-15-9-7-14(8-10-15)18(11-5-12-18)17-21-20-16-6-3-1-2-4-13-22(16)17/h7-10H,1-6,11-13H2 VUDAYPLDMBOUGX-UHFFFAOYSA-N 50377867 CHEMBL256514 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377867&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10470037 160856950 CHEMBL256514 ZINC29044806 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870467 Fc1cccc(c1)C1(CCC1)c1nnc2CCCCCCn12 InChI=1S/C18H22FN3/c19-15-8-5-7-14(13-15)18(10-6-11-18)17-21-20-16-9-3-1-2-4-12-22(16)17/h5,7-8,13H,1-4,6,9-12H2 GTBJZZJXCRWFER-UHFFFAOYSA-N 50377868 CHEMBL255660 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377868&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10447474 160856951 CHEMBL255660 ZINC29044803 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870468 C1CC(C1)(c1nnc2CCCCCCn12)c1ccccc1 InChI=1S/C18H23N3/c1-2-7-14-21-16(11-6-1)19-20-17(21)18(12-8-13-18)15-9-4-3-5-10-15/h3-5,9-10H,1-2,6-8,11-14H2 CXEWZZRORHISQU-UHFFFAOYSA-N 50377869 CHEMBL402552 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377869&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10446474 160856952 CHEMBL402552 ZINC29044811 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50870469 Oc1cccc(c1)C1(CCCC1)c1nnc2CCCCCCn12 InChI=1S/C19H25N3O/c23-16-9-7-8-15(14-16)19(11-4-5-12-19)18-21-20-17-10-3-1-2-6-13-22(17)18/h7-9,14,23H,1-6,10-13H2 PJENSBSIAHHTHI-UHFFFAOYSA-N 50377871 CHEMBL257414 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.1016/j.bmcl.2008.04.014 10.7270/Q2H99625 18440812 Zhu, Y; Olson, SH; Graham, D; Patel, G; Hermanowski-Vosatka, A; Mundt, S; Shah, K; Springer, M; Thieringer, R; Wright, S; Xiao, J; Zokian, H; Dragovic, J; Balkovec, JM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377871&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 10335644 160856954 CHEMBL257414 ZINC29044974 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50885033 Clc1cccc(c1)S(=O)(=O)NCc1ccc(cc1)C(=O)NC1CCCCCC1 InChI=1S/C21H25ClN2O3S/c22-18-6-5-9-20(14-18)28(26,27)23-15-16-10-12-17(13-11-16)21(25)24-19-7-3-1-2-4-8-19/h5-6,9-14,19,23H,1-4,7-8,15H2,(H,24,25) LVWCYWKEBPDQNM-UHFFFAOYSA-N 50297908 4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptylbenzamide::CHEMBL549600 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297908&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45270351 104139439 CHEMBL549600 ZINC43015081 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50885034 CN(C1CCCCCC1)C(=O)c1ccc(CNS(=O)(=O)c2cccc(Cl)c2)cc1 InChI=1S/C22H27ClN2O3S/c1-25(20-8-4-2-3-5-9-20)22(26)18-13-11-17(12-14-18)16-24-29(27,28)21-10-6-7-19(23)15-21/h6-7,10-15,20,24H,2-5,8-9,16H2,1H3 VZFUMZUWJFIKDW-UHFFFAOYSA-N 50297909 4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-methylbenzamide::CHEMBL552288 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2487 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297909&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45271171 104139440 CHEMBL552288 ZINC43063079 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50885035 CCCN(C1CCCCCC1)C(=O)c1ccc(CNS(=O)(=O)c2cccc(Cl)c2)cc1 InChI=1S/C24H31ClN2O3S/c1-2-16-27(22-9-5-3-4-6-10-22)24(28)20-14-12-19(13-15-20)18-26-31(29,30)23-11-7-8-21(25)17-23/h7-8,11-15,17,22,26H,2-6,9-10,16,18H2,1H3 JQJJNQAWLYPCQI-UHFFFAOYSA-N 50297910 4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-propylbenzamide::CHEMBL551949 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297910&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44250316 104139441 CHEMBL551949 ZINC43059321 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50885036 CCCCN(C1CCCCCC1)C(=O)c1ccc(CNS(=O)(=O)c2cccc(Cl)c2)cc1 InChI=1S/C25H33ClN2O3S/c1-2-3-17-28(23-10-6-4-5-7-11-23)25(29)21-15-13-20(14-16-21)19-27-32(30,31)24-12-8-9-22(26)18-24/h8-9,12-16,18,23,27H,2-7,10-11,17,19H2,1H3 ACFPACQQCZIIAG-UHFFFAOYSA-N 50297911 CHEMBL550065::N-butyl-4-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptylbenzamide 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297911&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45271081 104139442 CHEMBL550065 ZINC43011737 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50885037 Clc1cccc(c1)S(=O)(=O)NCc1ccc(cc1)C(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C24H27ClN2O3S/c25-21-2-1-3-22(11-21)31(29,30)26-15-16-4-6-20(7-5-16)23(28)27-24-12-17-8-18(13-24)10-19(9-17)14-24/h1-7,11,17-19,26H,8-10,12-15H2,(H,27,28) DITSVKMBGPBFDL-UHFFFAOYSA-N 50297912 4-[(3-Chlorophenylsulfonamido)methyl]-N-(1-adamantyl)benzamide::CHEMBL559418 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.bmcl.2009.05.033 10.7270/Q2VT1T1D 19564108 Zhang, X; Zhou, Z; Yang, H; Chen, J; Feng, Y; Du, L; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50297912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50297912&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 45269430 104139443 CHEMBL559418 ZINC43075629 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50933107 Clc1ccc2NC(=O)N(CC3CCN(CC3)C(=O)N(C3CC3)C3CCCCC3)S(=O)(=O)c2c1 InChI=1S/C23H31ClN4O4S/c24-17-6-9-20-21(14-17)33(31,32)27(22(29)25-20)15-16-10-12-26(13-11-16)23(30)28(19-7-8-19)18-4-2-1-3-5-18/h6,9,14,16,18-19H,1-5,7-8,10-13,15H2,(H,25,29) IKIIZIZOUKJDOA-UHFFFAOYSA-N 50382819 CHEMBL2023584 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2200 ChEMBL 10.1016/j.bmcl.2012.02.095 10.7270/Q22F7PGX 22440625 Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382819&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70687773 160861902 CHEMBL2023584 ZINC84587720 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50933108 CN(C1CCCCCC1)C(=O)N1CCC(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)CC1 InChI=1S/C22H31ClN4O4S/c1-25(18-6-4-2-3-5-7-18)22(29)26-12-10-16(11-13-26)15-27-21(28)24-19-9-8-17(23)14-20(19)32(27,30)31/h8-9,14,16,18H,2-7,10-13,15H2,1H3,(H,24,28) DFUDUOPNHOXDIK-UHFFFAOYSA-N 50382820 CHEMBL2023585 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 860 ChEMBL 10.1016/j.bmcl.2012.02.095 10.7270/Q22F7PGX 22440625 Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382820&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70691963 160861903 CHEMBL2023585 ZINC84586884 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50933109 CN(C1C2CC3CC(C2)CC1C3)C(=O)N1CCC(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)CC1 InChI=1S/C25H33ClN4O4S/c1-28(23-18-9-16-8-17(11-18)12-19(23)10-16)25(32)29-6-4-15(5-7-29)14-30-24(31)27-21-3-2-20(26)13-22(21)35(30,33)34/h2-3,13,15-19,23H,4-12,14H2,1H3,(H,27,31) USEVDAWMSYMUKI-UHFFFAOYSA-N 50382822 CHEMBL2023587 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 720 ChEMBL 10.1016/j.bmcl.2012.02.095 10.7270/Q22F7PGX 22440625 Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382822&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 70691964 160861905 CHEMBL2023587 ZINC84636006 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50937764 C[C@H](CC[C@H](O)C(C)=C)[C@H]1CC[C@]2([C@@H]3CC[C@@H]4[C@]5(C[C@@]35CC[C@]12C)CCC(=O)C4(C)C)C(O)=O InChI=1S/C30H46O4/c1-18(2)21(31)8-7-19(3)20-11-14-30(25(33)34)23-10-9-22-26(4,5)24(32)12-13-28(22)17-29(23,28)16-15-27(20,30)6/h19-23,31H,1,7-17H2,2-6H3,(H,33,34)/t19-,20-,21+,22+,23-,27-,28-,29+,30+/m1/s1 SYVTXPULSBCSAB-CMWTXFCNSA-N 50384886 CHEMBL2035568 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/np200831c 10.7270/Q27M090Q 22360639 Mpetga, JD; Shen, Y; Tane, P; Li, SF; He, HP; Wabo, HK; Tene, M; Leng, Y; Hao, XJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384886&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57408764 160863969 CHEMBL2035568 ZINC84723348 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50937765 C[C@H](CC[C@@H](O)C(C)(C)O)[C@H]1CC[C@]2([C@@H]3CC[C@@H]4[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O)C4(C)C)C(O)=O InChI=1S/C30H50O5/c1-18(7-10-23(32)26(4,5)35)19-11-14-30(24(33)34)21-9-8-20-25(2,3)22(31)12-13-28(20)17-29(21,28)16-15-27(19,30)6/h18-23,31-32,35H,7-17H2,1-6H3,(H,33,34)/t18-,19-,20+,21-,22+,23-,27-,28-,29+,30+/m1/s1 WDJQHANSLSJHNN-XEPWAXDFSA-N 50384887 CHEMBL2035569 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 400 ChEMBL 10.1021/np200831c 10.7270/Q27M090Q 22360639 Mpetga, JD; Shen, Y; Tane, P; Li, SF; He, HP; Wabo, HK; Tene, M; Leng, Y; Hao, XJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50384887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50384887&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57408765 160863970 CHEMBL2035569 ZINC84724672 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50937766 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)O[C@@H]1O[C@@H]([C@@H](O)[C@H](O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)[C@H]1O)C(O)=O InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-27(48)28(26(47)30(58-35)33(51)52)56-34-25(46)23(44)24(45)29(57-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25+,26-,27+,28-,29-,30-,31+,34+,35+,38+,39-,40-,41+,42+/m0/s1 KEIFOIQHFNUSQE-HDENPQJWSA-N 50359991 CHEMBL1927953 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 0.4 ChEMBL 10.1021/np200831c 10.7270/Q27M090Q 22360639 Mpetga, JD; Shen, Y; Tane, P; Li, SF; He, HP; Wabo, HK; Tene, M; Leng, Y; Hao, XJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50359991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50359991&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 21124245 136964015 CHEMBL1927953 C03033 ZINC96178998 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50955784 CCCSc1nc(ccc1C(=O)NC1CCCCC1)N1CCC[C@@H](CC(O)=O)C1 InChI=1S/C22H33N3O3S/c1-2-13-29-22-18(21(28)23-17-8-4-3-5-9-17)10-11-19(24-22)25-12-6-7-16(15-25)14-20(26)27/h10-11,16-17H,2-9,12-15H2,1H3,(H,23,28)(H,26,27)/t16-/m0/s1 NCDZABJPWMBMIQ-INIZCTEOSA-N 50392216 CHEMBL2153191::US8673938, 7 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1021/jm300592r 10.7270/Q24F1RTK 22691057 Scott, JS; Bowker, SS; Deschoolmeester, J; Gerhardt, S; Hargreaves, D; Kilgour, E; Lloyd, A; Mayers, RM; McCoull, W; Newcombe, NJ; Ogg, D; Packer, MJ; Rees, A; Revill, J; Schofield, P; Selmi, N; Swales, JG; Whittamore, PR AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392216&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 14M 24946280 163341240 CHEMBL2153191 ZINC95575356 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50952133 O=C(N1CCC(C1)c1c[nH]c2ncccc12)C1(CC1)c1ccccc1 InChI=1S/C21H21N3O/c25-20(21(9-10-21)16-5-2-1-3-6-16)24-12-8-15(14-24)18-13-23-19-17(18)7-4-11-22-19/h1-7,11,13,15H,8-10,12,14H2,(H,22,23) KONDYSYBNMOPRN-UHFFFAOYSA-N 50390700 CHEMBL2070227 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.07.070 10.7270/Q2Z89DH5 22901389 Valeur, E; Christmann-Franck, S; Lepifre, F; Carniato, D; Cravo, D; Charon, C; Bozec, S; Musil, D; Hillertz, P; Doare, L; Schmidlin, F; Lecomte, M; Schultz, M; Roche, D Merck Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50390700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50390700&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 42603038 160869783 CHEMBL2070227 ZINC43205061 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50952134 CC(C)(C(=O)N1CCC(C1)c1c[nH]c2ncccc12)c1ccc(Cl)cc1 InChI=1S/C21H22ClN3O/c1-21(2,15-5-7-16(22)8-6-15)20(26)25-11-9-14(13-25)18-12-24-19-17(18)4-3-10-23-19/h3-8,10,12,14H,9,11,13H2,1-2H3,(H,23,24) VGKMTBSSNGZXKS-UHFFFAOYSA-N 50390702 CHEMBL2070230 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2012.07.070 10.7270/Q2Z89DH5 22901389 Valeur, E; Christmann-Franck, S; Lepifre, F; Carniato, D; Cravo, D; Charon, C; Bozec, S; Musil, D; Hillertz, P; Doare, L; Schmidlin, F; Lecomte, M; Schultz, M; Roche, D Merck Serono http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50390702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50390702&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 25265683 160869785 CHEMBL2070230 ZINC43205053 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50960586 O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(nc1C1CC1)N1CCOCC1)C(C3)C2 InChI=1S/C22H30N4O3/c27-20(24-18-15-7-13-8-16(18)11-22(28,9-13)10-15)17-12-23-21(25-19(17)14-1-2-14)26-3-5-29-6-4-26/h12-16,18,28H,1-11H2,(H,24,27)/t13?,15?,16?,18-,22- IRAYWAXVFOQLKB-CPAHRSPMSA-N 50394004 CHEMBL2158485 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2012.08.070 10.7270/Q23R0V0G 23013933 Scott, JS; Gill, AL; Godfrey, L; Groombridge, SD; Rees, A; Revill, J; Schofield, P; Sorme, P; Stocker, A; Swales, JG; Whittamore, PR AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50394004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50394004&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57916503 163343028 CHEMBL2158485 ZINC95579503 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50957327 Cc1c(Cl)cccc1S(=O)(=O)N1CCC[C@]1(C)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C23H31ClN2O4S/c1-14-18(24)5-3-6-19(14)31(29,30)26-8-4-7-22(26,2)21(27)25-20-16-9-15-10-17(20)13-23(28,11-15)12-16/h3,5-6,15-17,20,28H,4,7-13H2,1-2H3,(H,25,27)/t15?,16?,17?,20-,22-,23-/m1/s1 IDOZZJFHEYUHMV-FCNBXJQRSA-N 50392924 CHEMBL2152223 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2200 ChEMBL 10.1021/ml300144n 10.7270/Q2K938NZ 24900382 Yu, J; Liu, H; Xia, G; Liu, L; Xu, Z; Chen, Q; Ma, C; Sun, X; Xu, J; Li, H; Li, P; Shi, Y; Xiong, B; Liu, X; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392924&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 71456572 163341948 CHEMBL2152223 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50957328 C[C@@]1(CCCN1S(=O)(=O)c1cccc2cccnc12)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 InChI=1S/C25H31N3O4S/c1-24(23(29)27-21-18-11-16-12-19(21)15-25(30,13-16)14-18)8-4-10-28(24)33(31,32)20-7-2-5-17-6-3-9-26-22(17)20/h2-3,5-7,9,16,18-19,21,30H,4,8,10-15H2,1H3,(H,27,29)/t16?,18?,19?,21-,24-,25-/m1/s1 FMAKUZMSDBENNW-OPDSBUNKSA-N 50392938 CHEMBL2152237 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/ml300144n 10.7270/Q2K938NZ 24900382 Yu, J; Liu, H; Xia, G; Liu, L; Xu, Z; Chen, Q; Ma, C; Sun, X; Xu, J; Li, H; Li, P; Shi, Y; Xiong, B; Liu, X; Shen, J TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392938&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 71458421 163341962 CHEMBL2152237 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50973765 CC(C)(C)c1c(cnn1-c1ccc(cc1)C(O)=O)C(=O)NC1C2CC3CC(C2)CC1C3 InChI=1S/C25H31N3O3/c1-25(2,3)22-20(13-26-28(22)19-6-4-16(5-7-19)24(30)31)23(29)27-21-17-9-14-8-15(11-17)12-18(21)10-14/h4-7,13-15,17-18,21H,8-12H2,1-3H3,(H,27,29)(H,30,31) XWBXJBSVYVJAMZ-UHFFFAOYSA-N 50399335 CHEMBL2177609 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1021/jm301252n 10.7270/Q2WM1FJT 23088558 Scott, JS; deSchoolmeester, J; Kilgour, E; Mayers, RM; Packer, MJ; Hargreaves, D; Gerhardt, S; Ogg, DJ; Rees, A; Selmi, N; Stocker, A; Swales, JG; Whittamore, PR AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399335&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 21T 25006684 163348359 CHEMBL2177609 ZINC95578030 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51081759 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@H](C[C@]12C)NC[C@H](N)C(O)=O InChI=1S/C24H36N2O4/c1-13(27)17-6-7-18-16-5-4-14-10-15(28)8-9-23(14,2)21(16)20(11-24(17,18)3)26-12-19(25)22(29)30/h10,16-21,26H,4-9,11-12,25H2,1-3H3,(H,29,30)/t16-,17+,18-,19-,20-,21+,23-,24+/m0/s1 YVGKPKBONYGPMB-JNMIDYNYSA-N 50442537 CHEMBL2440894 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 6760 ChEMBL 10.1016/j.bmc.2013.08.068 10.7270/Q2NS0WC4 24074876 Pandya, K; Dietrich, D; Seibert, J; Vederas, JC; Odermatt, A University of Alberta http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442537&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 72204732 175454854 CHEMBL2440894 ZINC96286219 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51081760 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@H](C[C@]12C)NC[C@@H](CO)NC(=O)OC(C)(C)C InChI=1S/C29H46N2O5/c1-17(33)22-9-10-23-21-8-7-18-13-20(34)11-12-28(18,5)25(21)24(14-29(22,23)6)30-15-19(16-32)31-26(35)36-27(2,3)4/h13,19,21-25,30,32H,7-12,14-16H2,1-6H3,(H,31,35)/t19-,21-,22+,23-,24-,25+,28-,29+/m0/s1 YUDWCNHAOLNFDB-QEDGXHOQSA-N 50442538 CHEMBL2440893 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 4210 ChEMBL 10.1016/j.bmc.2013.08.068 10.7270/Q2NS0WC4 24074876 Pandya, K; Dietrich, D; Seibert, J; Vederas, JC; Odermatt, A University of Alberta http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442538&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 72204534 175454855 CHEMBL2440893 ZINC96286220 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51081761 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@H](C[C@]12C)NC[C@H]1COC(C)(C)N1C(=O)OC(C)(C)C InChI=1S/C32H50N2O5/c1-19(35)24-11-12-25-23-10-9-20-15-22(36)13-14-31(20,7)27(23)26(16-32(24,25)8)33-17-21-18-38-30(5,6)34(21)28(37)39-29(2,3)4/h15,21,23-27,33H,9-14,16-18H2,1-8H3/t21-,23-,24+,25-,26-,27+,31-,32+/m0/s1 VKPHLSBBJMKUQB-CGRWWXBZSA-N 50442539 CHEMBL2440892 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 5850 ChEMBL 10.1016/j.bmc.2013.08.068 10.7270/Q2NS0WC4 24074876 Pandya, K; Dietrich, D; Seibert, J; Vederas, JC; Odermatt, A University of Alberta http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442539&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 72204340 175454856 CHEMBL2440892 ZINC96286221 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51081762 CCOC(=O)C(NO)C=N[C@H]1C[C@@]2(C)[C@@H](CC[C@@H]2C(C)=O)[C@@H]2CCC3=CC(=O)CC[C@]3(C)[C@@H]12 InChI=1S/C26H38N2O5/c1-5-33-24(31)22(28-32)14-27-21-13-26(4)19(15(2)29)8-9-20(26)18-7-6-16-12-17(30)10-11-25(16,3)23(18)21/h12,14,18-23,28,32H,5-11,13H2,1-4H3/t18-,19+,20-,21-,22?,23+,25-,26+/m0/s1 GWKNZAIXTHYDEV-PPEZWOBISA-N 50442535 CHEMBL2440126 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1050 ChEMBL 10.1016/j.bmc.2013.08.068 10.7270/Q2NS0WC4 24074876 Pandya, K; Dietrich, D; Seibert, J; Vederas, JC; Odermatt, A University of Alberta http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442535&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 91898581 175454852 CHEMBL2440126 ZINC96286218 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51081763 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@H](C[C@]12C)NCC(O)=O InChI=1S/C23H33NO4/c1-13(25)17-6-7-18-16-5-4-14-10-15(26)8-9-22(14,2)21(16)19(11-23(17,18)3)24-12-20(27)28/h10,16-19,21,24H,4-9,11-12H2,1-3H3,(H,27,28)/t16-,17+,18-,19-,21+,22-,23+/m0/s1 YLVGBZUGOFZMTJ-ANGCPZDQSA-N 50442540 CHEMBL2440891 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2690 ChEMBL 10.1016/j.bmc.2013.08.068 10.7270/Q2NS0WC4 24074876 Pandya, K; Dietrich, D; Seibert, J; Vederas, JC; Odermatt, A University of Alberta http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442540&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 72204155 175454857 CHEMBL2440891 ZINC96286222 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51081764 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@H](C[C@]12C)NCC(=O)OC(C)(C)C InChI=1S/C27H41NO4/c1-16(29)20-9-10-21-19-8-7-17-13-18(30)11-12-26(17,5)24(19)22(14-27(20,21)6)28-15-23(31)32-25(2,3)4/h13,19-22,24,28H,7-12,14-15H2,1-6H3/t19-,20+,21-,22-,24+,26-,27+/m0/s1 KSKUOVWHZUFSQK-OPCRWSCESA-N 50442541 CHEMBL2440890 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2410 ChEMBL 10.1016/j.bmc.2013.08.068 10.7270/Q2NS0WC4 24074876 Pandya, K; Dietrich, D; Seibert, J; Vederas, JC; Odermatt, A University of Alberta http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442541&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 72204153 175454858 CHEMBL2440890 ZINC96286223 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51081765 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](N)C[C@]12C InChI=1S/C21H31NO2/c1-12(23)16-6-7-17-15-5-4-13-10-14(24)8-9-20(13,2)19(15)18(22)11-21(16,17)3/h10,15-19H,4-9,11,22H2,1-3H3/t15-,16+,17-,18-,19+,20-,21+/m0/s1 JJZRNDBNQRDGDF-ATWVFEABSA-N 50442542 11BETA-AMINOPROGESTERONE 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2200 ChEMBL 10.1016/j.bmc.2013.08.068 10.7270/Q2NS0WC4 24074876 Pandya, K; Dietrich, D; Seibert, J; Vederas, JC; Odermatt, A University of Alberta http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442542&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 72204152 175454859 ZINC78204860 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51081766 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@H](O)C[C@]12C InChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17-,18+,19+,20-,21+/m0/s1 BFZHCUBIASXHPK-QJSKAATBSA-N 50442536 CHEMBL1563246 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 400 ChEMBL 10.1016/j.bmc.2013.08.068 10.7270/Q2NS0WC4 24074876 Pandya, K; Dietrich, D; Seibert, J; Vederas, JC; Odermatt, A University of Alberta http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442536&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 92730 175454853 16076 CHEMBL1563246 C03747 ZINC03881614 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51081767 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@]12C InChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17-,18-,19+,20-,21+/m0/s1 BFZHCUBIASXHPK-ATWVFEABSA-N 50442531 11BETA-HYDROXYPROGESTERONE 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 490 ChEMBL 10.1016/j.bmc.2013.08.068 10.7270/Q2NS0WC4 24074876 Pandya, K; Dietrich, D; Seibert, J; Vederas, JC; Odermatt, A University of Alberta http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442531&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101788 175454848 28247 C05498 ZINC00586491 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50975797 O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(N[C@H]4CCOC4)nc1C1CCCC1)C(C3)C2 InChI=1S/C24H34N4O3/c29-22(27-20-16-7-14-8-17(20)11-24(30,9-14)10-16)19-12-25-23(26-18-5-6-31-13-18)28-21(19)15-3-1-2-4-15/h12,14-18,20,30H,1-11,13H2,(H,27,29)(H,25,26,28)/t14?,16?,17?,18-,20-,24-/m0/s1 VMTZDIHMLVWUQZ-CKAXPNCZSA-N 50400147 CHEMBL2179014 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1021/jm3013163 10.7270/Q2BG2Q4S 23153367 Goldberg, FW; Leach, AG; Scott, JS; Snelson, WL; Groombridge, SD; Donald, CS; Bennett, SN; Bodin, C; Gutierrez, PM; Gyte, AC AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400147&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52911994 163349171 CHEMBL2179014 ZINC95573421 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50975798 O[C@@]12CC3CC(C1)[C@H](NC(=O)c1cnc(NC4CCOCC4)nc1C1CCC1)C(C3)C2 InChI=1S/C24H34N4O3/c29-22(27-20-16-8-14-9-17(20)12-24(30,10-14)11-16)19-13-25-23(26-18-4-6-31-7-5-18)28-21(19)15-2-1-3-15/h13-18,20,30H,1-12H2,(H,27,29)(H,25,26,28)/t14?,16?,17?,20-,24- SZQOXFDYAUHBOI-AKSATJCXSA-N 50400136 CHEMBL2179452 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >30000 ChEMBL 10.1021/jm3013163 10.7270/Q2BG2Q4S 23153367 Goldberg, FW; Leach, AG; Scott, JS; Snelson, WL; Groombridge, SD; Donald, CS; Bennett, SN; Bodin, C; Gutierrez, PM; Gyte, AC AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400136&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57916360 163349160 CHEMBL2179452 ZINC95572341 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51044912 C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F InChI=1S/C19H19F7N2O3S2/c1-11-10-27(14-4-3-12(20)9-13(14)18(21,22)23)7-8-28(11)33(30,31)16-6-5-15(32-16)17(2,29)19(24,25)26/h3-6,9,11,29H,7-8,10H2,1-2H3/t11-,17-/m1/s1 KMOODFIUONBYCX-PIGZYNQJSA-N 50426475 CHEMBL2322705 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/ml300352x 10.7270/Q25B03TM 24900572 Wan, ZK; Chenail, E; Li, HQ; Ipek, M; Xiang, J; Suri, V; Hahm, S; Bard, J; Svenson, K; Xu, X; Tian, X; Wang, M; Li, X; Johnson, CE; Qadri, A; Panza, D; Perreault, M; Mansour, TS; Tobin, JF; Saiah, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426475&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 57418438 164155350 CHEMBL2322705 ZINC95581253 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51044964 C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(s1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F InChI=1S/C19H18F7N3O4S2/c1-10-9-28(13-3-2-11(20)8-12(13)18(21,22)23)6-7-29(10)35(32,33)15-5-4-14(34-15)17(31,16(27)30)19(24,25)26/h2-5,8,10,31H,6-7,9H2,1H3,(H2,27,30)/t10-,17-/m1/s1 AQHKFYHHIIOAEO-BMLIUANNSA-N 50426478 CHEMBL2323021 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/ml300352x 10.7270/Q25B03TM 24900572 Wan, ZK; Chenail, E; Li, HQ; Ipek, M; Xiang, J; Suri, V; Hahm, S; Bard, J; Svenson, K; Xu, X; Tian, X; Wang, M; Li, X; Johnson, CE; Qadri, A; Panza, D; Perreault, M; Mansour, TS; Tobin, JF; Saiah, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426478&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 49846481 164155353 CHEMBL2323021 ZINC68247683 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51044965 C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)[C@@](O)(C(N)=O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F InChI=1S/C21H20F7N3O4S/c1-12-11-30(17-6-5-14(22)10-16(17)20(23,24)25)7-8-31(12)36(34,35)15-4-2-3-13(9-15)19(33,18(29)32)21(26,27)28/h2-6,9-10,12,33H,7-8,11H2,1H3,(H2,29,32)/t12-,19-/m1/s1 LDNXCAVPYKBBSI-CWTRNNRKSA-N 50426484 CHEMBL2323017 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1021/ml300352x 10.7270/Q25B03TM 24900572 Wan, ZK; Chenail, E; Li, HQ; Ipek, M; Xiang, J; Suri, V; Hahm, S; Bard, J; Svenson, K; Xu, X; Tian, X; Wang, M; Li, X; Johnson, CE; Qadri, A; Panza, D; Perreault, M; Mansour, TS; Tobin, JF; Saiah, E Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426484&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 49846838 164155359 CHEMBL2323017 ZINC95582654 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51038684 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)C(O)=O InChI=1S/C42H62O16/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7H3,(H,49,50)(H,51,52)(H,53,54)/t19-,21-,22-,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35-,38+,39-,40-,41+,42+/m0/s1 LPLVUJXQOOQHMX-QWBHMCJMSA-N 50185127 (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid::30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-beta-D-glucopyranosyluronic acid)-alpha-D-glucopyranosiduronic acid::CHEMBL441687::glycyrrhizic acid::glycyrrhizinic acid::glyzyrrhizin 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1.000000 ChEMBL 10.1016/j.bmcl.2012.02.095 10.7270/Q22F7PGX 22440625 Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50185127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50185127&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 14982 104069368 15939 CHEMBL441687 4688 C03033 ZINC96015174 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51067262 Cn1c(nnc1C12CCC(CC1)(CC2)c1nc(no1)-c1ccc(F)cc1)-c1ccccc1C(F)(F)F InChI=1S/C26H23F4N5O/c1-35-21(18-4-2-3-5-19(18)26(28,29)30)32-33-22(35)24-10-13-25(14-11-24,15-12-24)23-31-20(34-36-23)16-6-8-17(27)9-7-16/h2-9H,10-15H2,1H3 FRKIPPLTMSQJLF-UHFFFAOYSA-N 50174298 3-(4-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL373257 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3.0 ChEMBL 10.1016/j.bmcl.2013.03.011 10.7270/Q29S1SDM 23659858 Bauman, DR; Whitehead, A; Contino, LC; Cui, J; Garcia-Calvo, M; Gu, X; Kevin, N; Ma, X; Pai, LY; Shah, K; Shen, X; Stribling, S; Zokian, HJ; Metzger, J; Shevell, DE; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50174298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50174298&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 11526147 104060116 CHEMBL373257 ZINC03960657 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51067263 Cn1c(nnc1C12CCC(CC1)(CC2)c1noc(n1)C(C)(F)F)-c1ccccc1C(F)(F)F InChI=1S/C22H22F5N5O/c1-19(23,24)18-28-16(31-33-18)20-7-10-21(11-8-20,12-9-20)17-30-29-15(32(17)2)13-5-3-4-6-14(13)22(25,26)27/h3-6H,7-12H2,1-2H3 AHAIJYTWSYJSSZ-UHFFFAOYSA-N 50435691 CHEMBL2391968 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 30 ChEMBL 10.1016/j.bmcl.2013.03.011 10.7270/Q29S1SDM 23659858 Bauman, DR; Whitehead, A; Contino, LC; Cui, J; Garcia-Calvo, M; Gu, X; Kevin, N; Ma, X; Pai, LY; Shah, K; Shen, X; Stribling, S; Zokian, HJ; Metzger, J; Shevell, DE; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50435691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50435691&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 16222378 175448008 CHEMBL2391968 ZINC60325424 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51067264 CCS(=O)(=O)CCC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C22H28F3N3O2S/c1-3-31(29,30)15-14-20-8-11-21(12-9-20,13-10-20)19-27-26-18(28(19)2)16-6-4-5-7-17(16)22(23,24)25/h4-7H,3,8-15H2,1-2H3 ZQPJDHAUCVEXLU-UHFFFAOYSA-N 50340378 3-(4-(2-(ethylsulfonyl)ethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761313 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 7.5 ChEMBL 10.1016/j.bmcl.2013.03.011 10.7270/Q29S1SDM 23659858 Bauman, DR; Whitehead, A; Contino, LC; Cui, J; Garcia-Calvo, M; Gu, X; Kevin, N; Ma, X; Pai, LY; Shah, K; Shen, X; Stribling, S; Zokian, HJ; Metzger, J; Shevell, DE; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340378&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 22591709 131343314 CHEMBL1761313 ZINC43128373 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51067265 CCS(=O)(=O)CC12CCC(CC1)(CC2)c1nnc(-c2ccccc2C(F)(F)F)n1C InChI=1S/C21H26F3N3O2S/c1-3-30(28,29)14-19-8-11-20(12-9-19,13-10-19)18-26-25-17(27(18)2)15-6-4-5-7-16(15)21(22,23)24/h4-7H,3,8-14H2,1-2H3 IIUAOVVCEISVLV-UHFFFAOYSA-N 50340386 3-(4-(ethylsulfonylmethyl)bicyclo[2.2.2]octan-1-yl)-4-methyl-5-(2-(trifluoromethyl)phenyl)-4H-1,2,4-triazole::CHEMBL1761321 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 31 ChEMBL 10.1016/j.bmcl.2013.03.011 10.7270/Q29S1SDM 23659858 Bauman, DR; Whitehead, A; Contino, LC; Cui, J; Garcia-Calvo, M; Gu, X; Kevin, N; Ma, X; Pai, LY; Shah, K; Shen, X; Stribling, S; Zokian, HJ; Metzger, J; Shevell, DE; Waddell, ST Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340386&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44196869 131343322 CHEMBL1761321 ZINC71316756 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069750 C[C@@]1(CO)CCC[C@@]2(C)[C@@H]3CC[C@H]4C[C@]3(CC4=C)CC[C@H]12 InChI=1S/C20H32O/c1-14-11-20-10-7-16-18(2,13-21)8-4-9-19(16,3)17(20)6-5-15(14)12-20/h15-17,21H,1,4-13H2,2-3H3/t15?,16-,17+,18+,19-,20-/m1/s1 TUJQVRFWMWRMIO-LHYCJURKSA-N 50436974 CHEMBL512447 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 10000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436974&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24883422 175449291 15416 CHEMBL512447 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069757 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 MPDGHEJMBKOTSU-YKLVYJNSSA-N 50233538 18beta-glycyrrhetic acid::3beta-hydroxy-11-oxoolean-12-en-30-oic acid::CHEMBL230006::US11660306, Example 18beta Glycyrrhetinic acid::glycyrrhetinic acid 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1.2 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50233538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50233538&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CBW 10114 104055693 30853 CHEMBL230006 C02283 ZINC19203131 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069759 C[C@]1(CCC[C@@]2(C)[C@@H]3CC[C@H]4C[C@]3(CC4=C)CC[C@H]12)NC(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C30H46N2O/c1-19-14-29-10-7-24-27(2,25(29)6-5-23(19)18-29)8-4-9-28(24,3)31-26(33)32-30-15-20-11-21(16-30)13-22(12-20)17-30/h20-25H,1,4-18H2,2-3H3,(H2,31,32,33)/t20?,21?,22?,23?,24-,25-,27+,28+,29+,30?/m0/s1 HJWWPMKMOZZXEP-IRIVTISJSA-N 50436977 CHEMBL2402453 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436977&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73355069 175449294 CHEMBL2402453 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069760 C[C@]1(CCC[C@@]2(C)[C@@H]3CC[C@H]4C[C@]3(CC4=C)CC[C@H]12)NC(=O)Nc1ccc(F)cc1 InChI=1S/C26H35FN2O/c1-17-15-26-14-11-21-24(2,22(26)10-5-18(17)16-26)12-4-13-25(21,3)29-23(30)28-20-8-6-19(27)7-9-20/h6-9,18,21-22H,1,4-5,10-16H2,2-3H3,(H2,28,29,30)/t18?,21-,22-,24+,25+,26+/m0/s1 PBXADCZDDJNKAG-ISOLKDNHSA-N 50436978 CHEMBL2402452 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436978&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73352110 175449295 CHEMBL2402452 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069761 CC(=O)O[C@H]1C[C@H]2C[C@@]3(CC[C@H]4[C@@](C)(CCC[C@@]4(C)C(O)=O)[C@H]13)[C@H](O)C2=C InChI=1S/C22H32O5/c1-12-14-10-15(27-13(2)23)17-20(3)7-5-8-21(4,19(25)26)16(20)6-9-22(17,11-14)18(12)24/h14-18,24H,1,5-11H2,2-4H3,(H,25,26)/t14?,15-,16-,17-,18+,20+,21+,22+/m0/s1 XQWQGYFKRGMOKB-ONDQRRHOSA-N 50436979 CHEMBL2402475 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 228700 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436979&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73355072 175449296 CHEMBL2402475 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069762 CSC(=S)O[C@H]1C[C@H]2C[C@@]3(CC[C@H]4[C@@](C)(CCC[C@@]4(C)C(O)=O)[C@H]13)[C@H](O)C2=C InChI=1S/C22H32O4S2/c1-12-13-10-14(26-19(27)28-4)16-20(2)7-5-8-21(3,18(24)25)15(20)6-9-22(16,11-13)17(12)23/h13-17,23H,1,5-11H2,2-4H3,(H,24,25)/t13?,14-,15-,16-,17+,20+,21+,22+/m0/s1 IDZGFTWAKKXSDG-CXACYICDSA-N 50436980 CHEMBL2402473 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436980&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73356629 175449297 CHEMBL2402473 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069784 C[C@@]1(CO)CCC[C@@]2(C)[C@@H]3CC[C@H]4C[C@]3(C[C@]4(O)CO)CC[C@H]12 InChI=1S/C20H34O3/c1-17(12-21)7-3-8-18(2)15(17)6-9-19-10-14(4-5-16(18)19)20(23,11-19)13-22/h14-16,21-23H,3-13H2,1-2H3/t14?,15-,16+,17+,18-,19+,20+/m1/s1 VAKACABDOYKFHJ-IJNDJDAVSA-N 50436976 CHEMBL2402471 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436976&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73356628 175449293 CHEMBL2402471 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069785 C[C@@]12CCC[C@](C)([C@H]1CC[C@@]13C[C@H](CC[C@@H]21)[C@@](O)(CO)C3)C(O)=O InChI=1S/C20H32O4/c1-17-7-3-8-18(2,16(22)23)14(17)6-9-19-10-13(4-5-15(17)19)20(24,11-19)12-21/h13-15,21,24H,3-12H2,1-2H3,(H,22,23)/t13?,14-,15-,17+,18+,19-,20-/m0/s1 MRBLTWPEPGRXQN-YXUREUGOSA-N 50436975 CHEMBL490353 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436975&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 13994830 175449292 CHEMBL490353 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069796 C[C@]1(CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@H](C[C@H](O)[C@@H]21)C(=C)[C@H]3O)NC(=O)NC12CC3CC(CC(C3)C1)C2 InChI=1S/C30H46N2O3/c1-17-21-12-22(33)24-27(2)6-4-7-28(3,23(27)5-8-30(24,16-21)25(17)34)31-26(35)32-29-13-18-9-19(14-29)11-20(10-18)15-29/h18-25,33-34H,1,4-16H2,2-3H3,(H2,31,32,35)/t18?,19?,20?,21?,22-,23-,24-,25+,27+,28+,29?,30+/m0/s1 OTWYJTIJUNJWDN-JPBSPPQHSA-N 50436981 CHEMBL2402465 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 700 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436981&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73356626 175449298 CHEMBL2402465 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069797 C[C@]1(CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@H](C[C@H](O)[C@@H]21)C(=C)[C@H]3O)NC(=O)NC1CCCCC1 InChI=1S/C26H42N2O3/c1-16-17-14-19(29)21-24(2)11-7-12-25(3,20(24)10-13-26(21,15-17)22(16)30)28-23(31)27-18-8-5-4-6-9-18/h17-22,29-30H,1,4-15H2,2-3H3,(H2,27,28,31)/t17?,19-,20-,21-,22+,24+,25+,26+/m0/s1 XCRWPEYIRHEUAU-LDSKAJTASA-N 50436982 CHEMBL2402464 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436982&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73352112 175449299 CHEMBL2402464 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069798 C[C@]1(CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@H](C[C@H](O)[C@@H]21)C(=C)[C@H]3O)NC(=O)Nc1cccc2ccccc12 InChI=1S/C30H38N2O3/c1-18-20-16-23(33)25-28(2)13-7-14-29(3,24(28)12-15-30(25,17-20)26(18)34)32-27(35)31-22-11-6-9-19-8-4-5-10-21(19)22/h4-6,8-11,20,23-26,33-34H,1,7,12-17H2,2-3H3,(H2,31,32,35)/t20?,23-,24-,25-,26+,28+,29+,30+/m0/s1 XGYMDBRMYXHDIS-ZNVVJWODSA-N 50436983 CHEMBL2402461 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1600 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436983&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73345978 175449300 CHEMBL2402461 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069799 C[C@]1(CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@H](C[C@H](O)[C@@H]21)C(=C)[C@H]3O)NC(=O)Nc1ccc(F)cc1 InChI=1S/C26H35FN2O3/c1-15-16-13-19(30)21-24(2)10-4-11-25(3,20(24)9-12-26(21,14-16)22(15)31)29-23(32)28-18-7-5-17(27)6-8-18/h5-8,16,19-22,30-31H,1,4,9-14H2,2-3H3,(H2,28,29,32)/t16?,19-,20-,21-,22+,24+,25+,26+/m0/s1 WZBMHZHKXSXVOJ-SZUYDZFMSA-N 50436984 CHEMBL2402458 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >100000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436984&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73353568 175449301 CHEMBL2402458 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51069800 C[C@]1(CCC[C@]2(C)[C@@H]1CC[C@@]13C[C@H](C[C@H](O)[C@@H]21)C(=C)[C@H]3O)NC(=O)Nc1ccccc1 InChI=1S/C26H36N2O3/c1-16-17-14-19(29)21-24(2)11-7-12-25(3,20(24)10-13-26(21,15-17)22(16)30)28-23(31)27-18-8-5-4-6-9-18/h4-6,8-9,17,19-22,29-30H,1,7,10-15H2,2-3H3,(H2,27,28,31)/t17?,19-,20-,21-,22+,24+,25+,26+/m0/s1 PPFJQJCUBXHPMC-LDSKAJTASA-N 50436985 CHEMBL2402457 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2013.05.010 10.7270/Q2JS9RV7 23747808 Deng, X; Shen, Y; Yang, J; He, J; Zhao, Y; Peng, LY; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50436985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50436985&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 73356624 175449302 CHEMBL2402457 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51062445 COc1ccc(cc1)-c1cnc(nc1)N1CCN(C(=O)N2CCC(C2)c2cn[nH]c2)c2ccccc12 InChI=1S/C27H27N7O2/c1-36-23-8-6-19(7-9-23)21-14-28-26(29-15-21)33-12-13-34(25-5-3-2-4-24(25)33)27(35)32-11-10-20(18-32)22-16-30-31-17-22/h2-9,14-17,20H,10-13,18H2,1H3,(H,30,31) RHSTYEXBNNRSAD-UHFFFAOYSA-N 50340433 (3-(1H-pyrazol-4-yl)pyrrolidin-1-yl)(4-(5-(4-methoxyphenyl)pyrimidin-2-yl)-3,4-dihydroquinoxalin-1(2H)-yl)methanone::CHEMBL1761869 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2013.02.018 10.7270/Q2NV9KMN 23478147 Venier, O; Pascal, C; Braun, A; Namane, C; Mougenot, P; Crespin, O; Pacquet, F; Mougenot, C; Monseau, C; Onofri, B; Dadji-Faihun, R; Leger, C; Ben-Hassine, M; Van-Pham, T; Ragot, JL; Philippo, C; Farjot, G; Noah, L; Maniani, K; Boutarfa, A; Nicolai, E; Guillot, E; Pruniaux, MP; Gussregen, S; Engel, C; Coutant, AL; de Miguel, B; Castro, A Sanofi R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50340433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50340433&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 52918012 131343369 CHEMBL1761869 ZINC71318228 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51062446 CC(C)(C)N1CCN(CC1)c1ccc(nc1)N1CCN(C(=O)N[C@H]2C3CC4CC2C[C@](C4)(C3)C(N)=O)c2ccccc12 InChI=1S/C33H45N7O2/c1-32(2,3)38-12-10-37(11-13-38)25-8-9-28(35-21-25)39-14-15-40(27-7-5-4-6-26(27)39)31(42)36-29-23-16-22-17-24(29)20-33(18-22,19-23)30(34)41/h4-9,21-24,29H,10-20H2,1-3H3,(H2,34,41)(H,36,42)/t22?,23?,24?,29-,33- RZUKTDWPBQOSBE-PQFSURCISA-N 50433411 CHEMBL2380648 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2013.02.018 10.7270/Q2NV9KMN 23478147 Venier, O; Pascal, C; Braun, A; Namane, C; Mougenot, P; Crespin, O; Pacquet, F; Mougenot, C; Monseau, C; Onofri, B; Dadji-Faihun, R; Leger, C; Ben-Hassine, M; Van-Pham, T; Ragot, JL; Philippo, C; Farjot, G; Noah, L; Maniani, K; Boutarfa, A; Nicolai, E; Guillot, E; Pruniaux, MP; Gussregen, S; Engel, C; Coutant, AL; de Miguel, B; Castro, A Sanofi R & D http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433411&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 72670421 175445728 CHEMBL2380648 ZINC43207582 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50795666 C[C@H](N1CC[C@@](CC(C)(C)O)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccn(C)c(=O)c1 InChI=1S/C28H32N2O4/c1-20(21-10-12-22(13-11-21)23-14-16-29(4)25(31)18-23)30-17-15-28(34-26(30)32,19-27(2,3)33)24-8-6-5-7-9-24/h5-14,16,18,20,33H,15,17,19H2,1-4H3/t20-,28-/m0/s1 TXNPQZGSVXLGGP-MMTVBGGISA-N 107664 US8575157, 48 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2017.04.033 10.7270/Q2KS6V0F 28528082 Zhuang, L; Tice, CM; Xu, Z; Zhao, W; Cacatian, S; Ye, YJ; Singh, SB; Lindblom, P; McKeever, BM; Krosky, PM; Zhao, Y; Lala, D; Kruk, BA; Meng, S; Howard, L; Johnson, JA; Bukhtiyarov, Y; Panemangalore, R; Guo, J; Guo, R; Himmelsbach, F; Hamilton, B; Schuler-Metz, A; Schauerte, H; Gregg, R; McGeehan, GM; Leftheris, K; Claremon, DA Vitae Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107664&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 44476893 175445111 ZINC96178584 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50888232 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C[C@@H](O)[C@@H]2[C@@H](O)CC[C@@]32C)C1(C)C InChI=1S/C24H40O4/c1-14(25)28-19-9-10-22(4)17(21(19,2)3)8-12-23(5)18(22)13-16(27)20-15(26)7-11-24(20,23)6/h15-20,26-27H,7-13H2,1-6H3/t15-,16+,17-,18+,19-,20-,22-,23+,24+/m0/s1 XATLHNQIRONEBQ-AIPFBEDTSA-N 50267560 CHEMBL4102864 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2017.04.059 10.7270/Q2CF9SK2 28458137 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267560&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137656587 104114370 ZINC40423955 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50888233 C[C@@]12CCC=C1C(=O)C[C@@H]1[C@@]3(C)CC[C@H](O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C22H34O2/c1-19(2)16-8-12-22(5)17(20(16,3)11-9-18(19)24)13-15(23)14-7-6-10-21(14,22)4/h7,16-18,24H,6,8-13H2,1-5H3/t16-,17+,18-,20-,21+,22+/m0/s1 MLDXUANBJWSMDT-JPKYEYPISA-N 50267594 CHEMBL4103361 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 9582 ChEMBL 10.1016/j.ejmech.2017.04.059 10.7270/Q2CF9SK2 28458137 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267594&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137656441 404858548 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50888246 CCC(=O)CC[C@]1(C)C(=O)[C@H](O)C[C@@H]2[C@@]3(C)CC[C@H](OC(C)=O)C(C)(C)[C@@H]3CC[C@@]12C InChI=1S/C26H42O5/c1-8-17(28)9-13-26(7)22(30)18(29)15-20-24(5)12-11-21(31-16(2)27)23(3,4)19(24)10-14-25(20,26)6/h18-21,29H,8-15H2,1-7H3/t18-,19+,20-,21+,24+,25-,26-/m1/s1 ZQXRPVNZMWLJAD-AHKSPXFHSA-N 50267624 CHEMBL4064979 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 6261 ChEMBL 10.1016/j.ejmech.2017.04.059 10.7270/Q2CF9SK2 28458137 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50267624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50267624&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 137637923 404858550 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50888247 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1 MPDGHEJMBKOTSU-YKLVYJNSSA-N 50233538 18beta-glycyrrhetic acid::3beta-hydroxy-11-oxoolean-12-en-30-oic acid::CHEMBL230006::US11660306, Example 18beta Glycyrrhetinic acid::glycyrrhetinic acid 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1.3 ChEMBL 10.1016/j.ejmech.2017.04.059 10.7270/Q2CF9SK2 28458137 Shao, LD; Bao, Y; Shen, Y; Su, J; Leng, Y; Zhao, QS Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50233538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50233538&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CBW 10114 104055693 30853 CHEMBL230006 C02283 ZINC19203131 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50977260 O=C(C1CCCCC1)N1CC2C(C1)C1CCC2C=C1 InChI=1S/C17H25NO/c19-17(14-4-2-1-3-5-14)18-10-15-12-6-7-13(9-8-12)16(15)11-18/h6-7,12-16H,1-5,8-11H2 AVIULPKIBHPWHA-UHFFFAOYSA-N 50277179 CHEMBL4160328 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 100 ChEMBL 10.1016/j.ejmech.2017.08.003 10.7270/Q2JM2D5R 28818766 Leiva, R; Griñan-Ferré, C; Seira, C; Valverde, E; McBride, A; Binnie, M; Pérez, B; Luque, FJ; Pallàs, M; Bidon-Chanal, A; Webster, SP; Vázquez, S Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277179&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145960157 405257904 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50977261 O=C(C1CCCCC1)N1CC2C(C1)C1C=CC2C2CC12 InChI=1S/C18H25NO/c20-18(11-4-2-1-3-5-11)19-9-16-12-6-7-13(17(16)10-19)15-8-14(12)15/h6-7,11-17H,1-5,8-10H2 XEKLWKJPULBVKH-UHFFFAOYSA-N 50277197 CHEMBL4170544 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1000 ChEMBL 10.1016/j.ejmech.2017.08.003 10.7270/Q2JM2D5R 28818766 Leiva, R; Griñan-Ferré, C; Seira, C; Valverde, E; McBride, A; Binnie, M; Pérez, B; Luque, FJ; Pallàs, M; Bidon-Chanal, A; Webster, SP; Vázquez, S Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277197&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145956314 405257905 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50977337 O=C(C1CCCCC1)N1CC2C3CC(C=C3)C2C1 InChI=1S/C16H23NO/c18-16(11-4-2-1-3-5-11)17-9-14-12-6-7-13(8-12)15(14)10-17/h6-7,11-15H,1-5,8-10H2 DXMJULIKMLDOFU-UHFFFAOYSA-N 50277198 CHEMBL4163698 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <100 ChEMBL 10.1016/j.ejmech.2017.08.003 10.7270/Q2JM2D5R 28818766 Leiva, R; Griñan-Ferré, C; Seira, C; Valverde, E; McBride, A; Binnie, M; Pérez, B; Luque, FJ; Pallàs, M; Bidon-Chanal, A; Webster, SP; Vázquez, S Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277198&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145958039 405257906 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50977356 O=C(C1CCCCC1)N1CC2C3CCC(C3)C2C1 InChI=1S/C16H25NO/c18-16(11-4-2-1-3-5-11)17-9-14-12-6-7-13(8-12)15(14)10-17/h11-15H,1-10H2 VJMSNBQMSAFRGS-UHFFFAOYSA-N 50277202 CHEMBL4174368 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <100 ChEMBL 10.1016/j.ejmech.2017.08.003 10.7270/Q2JM2D5R 28818766 Leiva, R; Griñan-Ferré, C; Seira, C; Valverde, E; McBride, A; Binnie, M; Pérez, B; Luque, FJ; Pallàs, M; Bidon-Chanal, A; Webster, SP; Vázquez, S Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277202&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145952333 405257910 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50977357 O=C(C1CCCCC1)N1CC2C(C1)C1CCC2CC1 InChI=1S/C17H27NO/c19-17(14-4-2-1-3-5-14)18-10-15-12-6-7-13(9-8-12)16(15)11-18/h12-16H,1-11H2 CAKDWQKIRMNGHU-UHFFFAOYSA-N 50277203 CHEMBL4170932 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 100 ChEMBL 10.1016/j.ejmech.2017.08.003 10.7270/Q2JM2D5R 28818766 Leiva, R; Griñan-Ferré, C; Seira, C; Valverde, E; McBride, A; Binnie, M; Pérez, B; Luque, FJ; Pallàs, M; Bidon-Chanal, A; Webster, SP; Vázquez, S Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277203&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 145952000 405257911 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 50977358 O=C(C1CCCCC1)N1CC2C(C1)C1CCC2C2CC12 InChI=1S/C18H27NO/c20-18(11-4-2-1-3-5-11)19-9-16-12-6-7-13(17(16)10-19)15-8-14(12)15/h11-17H,1-10H2 WDHVLKXEKRBBSF-UHFFFAOYSA-N 50277178 CHEMBL4162610 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <100 ChEMBL 10.1016/j.ejmech.2017.08.003 10.7270/Q2JM2D5R 28818766 Leiva, R; Griñan-Ferré, C; Seira, C; Valverde, E; McBride, A; Binnie, M; Pérez, B; Luque, FJ; Pallàs, M; Bidon-Chanal, A; Webster, SP; Vázquez, S Universitat de Barcelona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277178&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 132053849 405257903 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228298 Nc1cccc(NS(=O)(=O)c2ccc(cc2)-c2ccc(cc2)C#N)n1 InChI=1S/C18H14N4O2S/c19-12-13-4-6-14(7-5-13)15-8-10-16(11-9-15)25(23,24)22-18-3-1-2-17(20)21-18/h1-11H,(H3,20,21,22) ZESFDAKNYJQYKO-UHFFFAOYSA-N 29864 N-(Pyridin-2-yl) arylsulfonamide, 26 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29864&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 23725123 85147628 ZINC40955326 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228299 CC(C)[C@@H]1CC[C@H](C(O)=O)[C@]11CC=C(C)[C@@H](O)C1 InChI=1S/C15H24O3/c1-9(2)11-4-5-12(14(17)18)15(11)7-6-10(3)13(16)8-15/h6,9,11-13,16H,4-5,7-8H2,1-3H3,(H,17,18)/t11-,12+,13-,15-/m0/s1 ZIOMQRRFPWLXDN-XFMPKHEZSA-N 50504041 CHEMBL4529787 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504041&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 7H6 24854349 440712626 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228313 COC1[C@H](O)C(=C)CC[C@@]11[C@@H](CC[C@@H]1C(O)=O)C(C)C InChI=1S/C16H26O4/c1-9(2)11-5-6-12(15(18)19)16(11)8-7-10(3)13(17)14(16)20-4/h9,11-14,17H,3,5-8H2,1-2,4H3,(H,18,19)/t11-,12+,13+,14?,16-/m0/s1 XTTYDSOYGKCFEX-AEEMWNSDSA-N 50504043 CHEMBL4448701 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504043&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155520336 440712628 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228314 CC(C)[C@@H]1CC[C@H](C(O)=O)[C@]11CCC(=C)[C@@H](O)C1 InChI=1S/C15H24O3/c1-9(2)11-4-5-12(14(17)18)15(11)7-6-10(3)13(16)8-15/h9,11-13,16H,3-8H2,1-2H3,(H,17,18)/t11-,12+,13-,15-/m0/s1 IXYLWIBRLBSRAT-XFMPKHEZSA-N 50504048 CHEMBL4566781 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504048&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155543491 440712633 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228315 C[C@@H]1CC[C@H](C(O)=O)[C@]11CCC(=C)[C@@H](O)C1 InChI=1S/C13H20O3/c1-8-5-6-13(7-11(8)14)9(2)3-4-10(13)12(15)16/h9-11,14H,1,3-7H2,2H3,(H,15,16)/t9-,10-,11+,13+/m1/s1 RPHUMFUPNVFYQV-DCQANWLSSA-N 50504042 CHEMBL4545661 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504042&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155553184 440712627 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228316 CC1=CC[C@@]2([C@@H](CC[C@@H]2C(O)=O)C2CCCCC2)[C@H](O)C1 InChI=1S/C18H28O3/c1-12-9-10-18(16(19)11-12)14(7-8-15(18)17(20)21)13-5-3-2-4-6-13/h9,13-16,19H,2-8,10-11H2,1H3,(H,20,21)/t14-,15+,16+,18-/m0/s1 PTRGRFWWNQFNOY-LHHMISFZSA-N 50504049 CHEMBL4450320 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504049&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155521135 440712634 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228317 CC(C)[C@@H]1CC[C@H](C(O)=O)[C@]11CC=C(C)C[C@H]1O InChI=1S/C15H24O3/c1-9(2)11-4-5-12(14(17)18)15(11)7-6-10(3)8-13(15)16/h6,9,11-13,16H,4-5,7-8H2,1-3H3,(H,17,18)/t11-,12+,13+,15-/m0/s1 FXYBBASEDHOEBZ-JLNYLFASSA-N 50504052 CHEMBL4552570 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504052&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155556588 440712637 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228318 CC(C)[C@@H]1CC[C@H](C(O)=O)[C@]11CC=C(C)C(=O)C1 InChI=1S/C15H22O3/c1-9(2)11-4-5-12(14(17)18)15(11)7-6-10(3)13(16)8-15/h6,9,11-12H,4-5,7-8H2,1-3H3,(H,17,18)/t11-,12+,15-/m0/s1 SXEWILOGQRBQJB-ZOWXZIJZSA-N 50504053 CHEMBL4536375 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504053&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155548236 440712638 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228319 CC(C)[C@@H]1CC[C@H](C(O)=O)[C@]11CC=C(C)[C@H](C1)OC(C)=O InChI=1S/C17H26O4/c1-10(2)13-5-6-14(16(19)20)17(13)8-7-11(3)15(9-17)21-12(4)18/h7,10,13-15H,5-6,8-9H2,1-4H3,(H,19,20)/t13-,14+,15-,17-/m0/s1 YCHHBBWGAXCKJR-IVSAIRAKSA-N 50504054 CHEMBL4588470 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504054&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155567250 440712639 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228322 CC(C)[C@@H]1CC[C@H](C(N)=O)[C@]11CC=C(C)[C@@H](O)C1 InChI=1S/C15H25NO2/c1-9(2)11-4-5-12(14(16)18)15(11)7-6-10(3)13(17)8-15/h6,9,11-13,17H,4-5,7-8H2,1-3H3,(H2,16,18)/t11-,12+,13-,15-/m0/s1 RHVMHLCRIZQGNC-XFMPKHEZSA-N 50504045 CHEMBL4571180 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504045&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155562798 440712630 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228323 CC(C)[C@@H]1CC[C@@H](C(O)=O)[C@]11CC=C(C)[C@@H](O)C1 InChI=1S/C15H24O3/c1-9(2)11-4-5-12(14(17)18)15(11)7-6-10(3)13(16)8-15/h6,9,11-13,16H,4-5,7-8H2,1-3H3,(H,17,18)/t11-,12-,13-,15-/m0/s1 ZIOMQRRFPWLXDN-ABHRYQDASA-N 50504046 CHEMBL4441254 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504046&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155515115 440712631 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228338 CC(C)[C@@H]1CC[C@H](C(O)=O)[C@]11CCC(=C)[C@H](C1)OC(C)=O InChI=1S/C17H26O4/c1-10(2)13-5-6-14(16(19)20)17(13)8-7-11(3)15(9-17)21-12(4)18/h10,13-15H,3,5-9H2,1-2,4H3,(H,19,20)/t13-,14+,15-,17-/m0/s1 IHTGVCLMNANZOA-IVSAIRAKSA-N 50504047 CHEMBL4475775 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504047&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155537728 440712632 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228339 CC1=CC[C@]2(C=C1)[C@@H](CC[C@@H]2C(O)=O)C1CCCCC1 InChI=1S/C18H26O2/c1-13-9-11-18(12-10-13)15(7-8-16(18)17(19)20)14-5-3-2-4-6-14/h9-11,14-16H,2-8,12H2,1H3,(H,19,20)/t15-,16+,18+/m0/s1 MJIQEQHXZPYDAR-LZLYRXPVSA-N 50504050 CHEMBL4436767 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504050&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155512106 440712635 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228341 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CCC(O)=O InChI=1S/C34H50O7/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40)/t21-,23-,24-,27+,30+,31-,32-,33+,34+/m0/s1 OBZHEBDUNPOCJG-WBXJDKIVSA-N 50247012 3beta-O-Succinyl-18-beta-glycyrrhetinic acid::Carbenoxolone::US11660306, Example Carbeanoxolone 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 170 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247012&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CBO 636403 104102199 ZINC38407010 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228349 CC1=CC[C@]2(C[C@@H]1O)[C@@H](CC[C@@H]2C(O)=O)C1CCCCC1 InChI=1S/C18H28O3/c1-12-9-10-18(11-16(12)19)14(7-8-15(18)17(20)21)13-5-3-2-4-6-13/h9,13-16,19H,2-8,10-11H2,1H3,(H,20,21)/t14-,15+,16-,18-/m0/s1 ZEQATYGPOXRDTP-DFGXFYAUSA-N 50504051 CHEMBL4450502 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504051&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155521284 440712636 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228350 CC(C)[C@@H]1CC[C@H](C(O)=O)[C@@]11C[C@H](O)[C@](C)(O)[C@H](O)C1 InChI=1S/C15H26O5/c1-8(2)9-4-5-10(13(18)19)15(9)6-11(16)14(3,20)12(17)7-15/h8-12,16-17,20H,4-7H2,1-3H3,(H,18,19)/t9-,10+,11-,12+,14-,15+/m0/s1 RDOSTDWOAZBZIE-SYPGZIFDSA-N 50504058 CHEMBL4528896 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504058&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155545095 440712643 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228351 C[C@]1(O)CC[C@]2(C[C@@H]1O)[C@@H](CC[C@@H]2C(O)=O)C1CCCCC1 InChI=1S/C18H30O4/c1-17(22)9-10-18(11-15(17)19)13(7-8-14(18)16(20)21)12-5-3-2-4-6-12/h12-15,19,22H,2-11H2,1H3,(H,20,21)/t13-,14+,15-,17-,18-/m0/s1 UIMOXPVUUUQAPY-CRCOGDFISA-N 50504056 CHEMBL4580823 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504056&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155561480 440712641 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228352 CC(C)[C@@H]1CC[C@H](C(O)=O)[C@]11CC[C@](C)(O)C[C@H]1OC(C)=O InChI=1S/C17H28O5/c1-10(2)12-5-6-13(15(19)20)17(12)8-7-16(4,21)9-14(17)22-11(3)18/h10,12-14,21H,5-9H2,1-4H3,(H,19,20)/t12-,13+,14+,16-,17-/m0/s1 LKPOSWRMEMZMEF-ZQQZQOJVSA-N 50504055 CHEMBL4457718 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504055&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155525513 440712640 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228353 CC(C)[C@H]1CC[C@@H](C(O)=O)[C@@]11CC=C(C)[C@H](O)C1 InChI=1S/C15H24O3/c1-9(2)11-4-5-12(14(17)18)15(11)7-6-10(3)13(16)8-15/h6,9,11-13,16H,4-5,7-8H2,1-3H3,(H,17,18)/t11-,12+,13-,15-/m1/s1 ZIOMQRRFPWLXDN-QVHKTLOISA-N 50504044 CHEMBL4548901 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504044&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155548826 440712629 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51228355 COC(=O)[C@H]1CC[C@@H](C(C)C)[C@@]11CC=C(C)[C@@H](O)C1 InChI=1S/C16H26O3/c1-10(2)12-5-6-13(15(18)19-4)16(12)8-7-11(3)14(17)9-16/h7,10,12-14,17H,5-6,8-9H2,1-4H3/t12-,13+,14-,16-/m0/s1 UOWPRQGHXKLWDQ-FQLMCAECSA-N 50504057 CHEMBL4531837 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >500000 ChEMBL 10.1021/acs.jmedchem.9b00187 10.7270/Q23R0X43 31294974 Ling, T; Miller, DJ; Lang, WH; Griffith, E; Rodriguez-Cortes, A; El Ayachi, I; Palacios, G; Min, J; Miranda-Carboni, G; Lee, RE; Rivas, F The University of Tennessee Health Science Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50504057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50504057&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 24854350 440712642 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51361565 C[C@@H]1CN(CCN1c1nccc(n1)C(=O)NC1C2CC3CC1CC(O)(C3)C2)c1ccc(cc1F)S(C)(=O)=O InChI=1S/C27H34FN5O4S/c1-16-15-32(23-4-3-20(11-21(23)28)38(2,36)37)7-8-33(16)26-29-6-5-22(30-26)25(34)31-24-18-9-17-10-19(24)14-27(35,12-17)13-18/h3-6,11,16-19,24,35H,7-10,12-15H2,1-2H3,(H,31,34)/t16-,17?,18?,19?,24?,27?/m1/s1 SSKKTEYBWOVEET-REKAHOPZSA-N 50550263 CHEMBL4748750 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.6b01122 10.7270/Q27P930B 27798827 Ryu, JH; Lee, JA; Kim, S; Shin, YA; Yang, J; Han, HY; Son, HJ; Kim, YH; Sa, JH; Kim, JS; Lee, J; Lee, J; Park, HG SK Chemicals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50550263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50550263&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 67466126 461680603 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51476185 C1C2CC3CC1CC(C2)(C3)c1nnc2CCCCCn12 InChI=1S/C17H25N3/c1-2-4-15-18-19-16(20(15)5-3-1)17-9-12-6-13(10-17)8-14(7-12)11-17/h12-14H,1-11H2 VFTQRHWULYJKCI-UHFFFAOYSA-N 50239401 3-Adamantan-1-yl-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine::CHEMBL256777::MERCK-544 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >4000 ChEMBL 10.7270/Q2FF3XBX 35537608 Zhang, C; Xu, M; He, C; Zhuo, J; Burns, DM; Qian, DQ; Lin, Q; Li, YL; Chen, L; Shi, E; Agrios, C; Weng, L; Sharief, V; Jalluri, R; Li, Y; Scherle, P; Diamond, S; Hunter, D; Covington, M; Marando, C; Wynn, R; Katiyar, K; Contel, N; Vaddi, K; Yeleswaram, S; Hollis, G; Huber, R; Friedman, S; Metcalf, B; Yao, W Incyte Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239401&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 3630776 104056507 CHEMBL256777 ZINC05494877 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51476186 CN1CCN(CC1)C(=O)Cc1cnc(NS(=O)(=O)c2cccc(Cl)c2C)s1 InChI=1S/C17H21ClN4O3S2/c1-12-14(18)4-3-5-15(12)27(24,25)20-17-19-11-13(26-17)10-16(23)22-8-6-21(2)7-9-22/h3-5,11H,6-10H2,1-2H3,(H,19,20) SNNOQQLUFSIPLF-UHFFFAOYSA-N 50595163 CHEMBL5199720 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 ChEMBL 10.7270/Q2FF3XBX 35537608 Zhang, C; Xu, M; He, C; Zhuo, J; Burns, DM; Qian, DQ; Lin, Q; Li, YL; Chen, L; Shi, E; Agrios, C; Weng, L; Sharief, V; Jalluri, R; Li, Y; Scherle, P; Diamond, S; Hunter, D; Covington, M; Marando, C; Wynn, R; Katiyar, K; Contel, N; Vaddi, K; Yeleswaram, S; Hollis, G; Huber, R; Friedman, S; Metcalf, B; Yao, W Incyte Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50595163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50595163&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168291771 482606015 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362425 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)C(O)=O InChI=1S/C31H46O5/c1-26(2)18(24(33)34)8-10-29(5)22(26)9-11-31(7)23(29)21(32)16-19-20-17-28(4,25(35)36)13-12-27(20,3)14-15-30(19,31)6/h16,18,20,22-23H,8-15,17H2,1-7H3,(H,33,34)(H,35,36)/t18-,20+,22+,23-,27-,28+,29+,30-,31-/m1/s1 ACNQSEAJFQHYLI-LEYZWCBYSA-N 642870 (2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,10-dicarboxylic acid::US11858959, Compound 1-5 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3162 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642870&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 138502321 488875713 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362426 CC1OC(=O)OC1COC(=O)[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C36H52O8/c1-20-25(44-30(41)43-20)19-42-28(38)21-9-11-34(6)26(31(21,2)3)10-12-36(8)27(34)24(37)17-22-23-18-33(5,29(39)40)14-13-32(23,4)15-16-35(22,36)7/h17,20-21,23,25-27H,9-16,18-19H2,1-8H3,(H,39,40)/t20?,21-,23+,25?,26+,27-,32-,33+,34+,35-,36-/m1/s1 IONPZJFPSBVQNQ-PTTLPNFESA-N 642871 (2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-Heptamethyl-10-(((5-methyl-2-oxo-1,3-dioxolan-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 178-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642871&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725268 488875714 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362427 Cc1oc(=O)oc1COC(=O)[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C36H50O8/c1-20-25(44-30(41)43-20)19-42-28(38)21-9-11-34(6)26(31(21,2)3)10-12-36(8)27(34)24(37)17-22-23-18-33(5,29(39)40)14-13-32(23,4)15-16-35(22,36)7/h17,21,23,26-27H,9-16,18-19H2,1-8H3,(H,39,40)/t21-,23+,26+,27-,32-,33+,34+,35-,36-/m1/s1 NYSNZQFPZLMDBT-LPRQLXAWSA-N 642872 (2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-Heptamethyl-10-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 176-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642872&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719197 488875715 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362428 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](C(=O)OCC5COC(=O)O5)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O InChI=1S/C35H50O8/c1-30(2)21(27(37)41-18-20-19-42-29(40)43-20)8-10-33(5)25(30)9-11-35(7)26(33)24(36)16-22-23-17-32(4,28(38)39)13-12-31(23,3)14-15-34(22,35)6/h16,20-21,23,25-26H,8-15,17-19H2,1-7H3,(H,38,39)/t20?,21-,23+,25+,26-,31-,32+,33+,34-,35-/m1/s1 XKENMTWDQUOPBK-QAKAGYLFSA-N 642873 (2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-10-{[(2-oxo-1,3-dioxolan-4-yl)methoxy]carbonyl}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 700-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 794 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642873&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725392 488875716 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362429 CSCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C33H48O7S/c1-28-12-13-29(2,26(36)37)17-20(28)19-16-21(34)25-30(3)10-9-23(40-24(35)18-41-7)33(6,27(38)39)22(30)8-11-32(25,5)31(19,4)15-14-28/h16,20,22-23,25H,8-15,17-18H2,1-7H3,(H,36,37)(H,38,39)/t20-,22+,23-,25+,28+,29-,30-,31+,32+,33-/m0/s1 SJXFUSLUZVBZBF-VRZLTMKRSA-N 642874 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-10-{[2-(methylsulfanyl)acetyl]oxy}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 1-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3981 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642874&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146469 488875717 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362430 CSCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C38H52O10S/c1-21-25(47-32(44)46-21)19-45-31(43)38(7)26-9-12-37(6)29(35(26,4)11-10-27(38)48-28(40)20-49-8)24(39)17-22-23-18-34(3,30(41)42)14-13-33(23,2)15-16-36(22,37)5/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,41,42)/t23-,26+,27-,29+,33+,34-,35-,36+,37+,38-/m0/s1 CAGVAYFDLRIYPB-DFSFSSLLSA-N 642875 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-Hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(2-(methylthio)acetoxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 194-10 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 10.0 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642875&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719239 488875718 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362431 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CS(C)(=O)=O InChI=1S/C38H52O12S/c1-21-25(49-32(44)48-21)19-47-31(43)38(7)26-9-12-37(6)29(35(26,4)11-10-27(38)50-28(40)20-51(8,45)46)24(39)17-22-23-18-34(3,30(41)42)14-13-33(23,2)15-16-36(22,37)5/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,41,42)/t23-,26+,27-,29+,33+,34-,35-,36+,37+,38-/m0/s1 AZVXLLRFDOEERV-DFSFSSLLSA-N 642876 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-Hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(2-(methyl sulfonyl)acetoxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 195-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642876&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719241 488875719 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362432 CSCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C(C)C InChI=1S/C40H56O10S/c1-22(2)30-26(48-34(46)50-30)20-47-33(45)40(8)27-10-13-39(7)31(37(27,5)12-11-28(40)49-29(42)21-51-9)25(41)18-23-24-19-36(4,32(43)44)15-14-35(24,3)16-17-38(23,39)6/h18,22,24,27-28,31H,10-17,19-21H2,1-9H3,(H,43,44)/t24-,27+,28-,31+,35+,36-,37-,38+,39+,40-/m0/s1 WTEMXJJQNQSDJG-YYDDGKOJSA-N 642877 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-10-{[2-(methylsulfanyl)acetyl]oxy}-13-oxo-9-({[2-oxo-5-(propan-2-yl)-2H-1,3-dioxol-4-yl]methoxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 701-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 100 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642877&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725362 488875720 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362433 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)CS(C)(=O)=O)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C33H48O9S/c1-28-12-13-29(2,26(36)37)17-20(28)19-16-21(34)25-30(3)10-9-23(42-24(35)18-43(7,40)41)33(6,27(38)39)22(30)8-11-32(25,5)31(19,4)15-14-28/h16,20,22-23,25H,8-15,17-18H2,1-7H3,(H,36,37)(H,38,39)/t20-,22+,23-,25+,28+,29-,30-,31+,32+,33-/m0/s1 QOFWOGQUMUMZNR-VRZLTMKRSA-N 642878 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-methanesulfonylacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 2-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <10000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642878&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146471 488875721 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362434 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CS(C)(=O)=O InChI=1S/C38H52O12S/c1-21-25(49-32(44)48-21)19-47-31(43)38(7)26-9-12-37(6)29(35(26,4)11-10-27(38)50-28(40)20-51(8,45)46)24(39)17-22-23-18-34(3,30(41)42)14-13-33(23,2)15-16-36(22,37)5/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,41,42)/t23-,26+,27-,29+,33+,34-,35-,36+,37+,38-/m0/s1 AZVXLLRFDOEERV-DFSFSSLLSA-N 642876 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-Hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(2-(methyl sulfonyl)acetoxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 195-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642876&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719241 488875719 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362435 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)c5ccccc5)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C37H48O7/c1-32-16-17-33(2,30(40)41)21-24(32)23-20-25(38)28-34(3)14-13-27(44-29(39)22-10-8-7-9-11-22)37(6,31(42)43)26(34)12-15-36(28,5)35(23,4)19-18-32/h7-11,20,24,26-28H,12-19,21H2,1-6H3,(H,40,41)(H,42,43)/t24-,26+,27-,28+,32+,33-,34-,35+,36+,37-/m0/s1 IGFUDYNRGRBXOG-ULRRUDSZSA-N 642879 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(benzoyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 3-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 251 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642879&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 170795497 488875722 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362436 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)c1ccccc1 InChI=1S/C42H52O10/c1-24-29(51-36(48)50-24)23-49-35(47)42(7)30-13-16-41(6)32(39(30,4)15-14-31(42)52-33(44)25-11-9-8-10-12-25)28(43)21-26-27-22-38(3,34(45)46)18-17-37(27,2)19-20-40(26,41)5/h8-12,21,27,30-32H,13-20,22-23H2,1-7H3,(H,45,46)/t27-,30+,31-,32+,37+,38-,39-,40+,41+,42-/m0/s1 KRNTZYPJGFOJQY-YFVMYGIQSA-N 642880 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(Benzoyloxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 197-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 12.6 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642880&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047258 488875723 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362437 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)C5CC5)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C34H48O7/c1-29-13-14-30(2,27(37)38)18-21(29)20-17-22(35)25-31(3)11-10-24(41-26(36)19-7-8-19)34(6,28(39)40)23(31)9-12-33(25,5)32(20,4)16-15-29/h17,19,21,23-25H,7-16,18H2,1-6H3,(H,37,38)(H,39,40)/t21-,23+,24-,25+,29+,30-,31-,32+,33+,34-/m0/s1 ILKKJBFAAPQKDB-CATRINGESA-N 642881 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(cyclopropanecarbonyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 4-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1585 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642881&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146468 488875724 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362438 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)C1CC1 InChI=1S/C39H52O10/c1-21-26(48-33(45)47-21)20-46-32(44)39(7)27-10-13-38(6)29(36(27,4)12-11-28(39)49-30(41)22-8-9-22)25(40)18-23-24-19-35(3,31(42)43)15-14-34(24,2)16-17-37(23,38)5/h18,22,24,27-29H,8-17,19-20H2,1-7H3,(H,42,43)/t24-,27+,28-,29+,34+,35-,36-,37+,38+,39-/m0/s1 KNTXPMCWIUDXLY-MKYWAOEHSA-N 642882 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((Cyclopropanecarbonyl)oxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 198-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 20.0 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642882&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719234 488875725 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362439 COCO[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C32H48O7/c1-27-12-13-28(2,25(34)35)17-20(27)19-16-21(33)24-29(3)10-9-23(39-18-38-7)32(6,26(36)37)22(29)8-11-31(24,5)30(19,4)15-14-27/h16,20,22-24H,8-15,17-18H2,1-7H3,(H,34,35)(H,36,37)/t20-,22+,23-,24+,27+,28-,29-,30+,31+,32-/m0/s1 XCVZFAOFJNWMLX-YWRAXVRTSA-N 642883 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(methoxymethoxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 5-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 7943 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642883&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146467 488875726 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362440 COCO[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C37H52O10/c1-21-25(47-31(42)46-21)19-44-30(41)37(7)26-9-12-36(6)28(34(26,4)11-10-27(37)45-20-43-8)24(38)17-22-23-18-33(3,29(39)40)14-13-32(23,2)15-16-35(22,36)5/h17,23,26-28H,9-16,18-20H2,1-8H3,(H,39,40)/t23-,26+,27-,28+,32+,33-,34-,35+,36+,37-/m0/s1 IRIIXTVQPFXSMZ-BKACUEHDSA-N 642884 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(Methoxymethoxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 205-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 398 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642884&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719266 488875727 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362441 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C32H46O7/c1-18(33)39-23-9-10-29(4)22(32(23,7)26(37)38)8-11-31(6)24(29)21(34)16-19-20-17-28(3,25(35)36)13-12-27(20,2)14-15-30(19,31)5/h16,20,22-24H,8-15,17H2,1-7H3,(H,35,36)(H,37,38)/t20-,22+,23-,24+,27+,28-,29-,30+,31+,32-/m0/s1 LGXOVMBLQAXCGN-YWRAXVRTSA-N 642885 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 6-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1259 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642885&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719210 488875728 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362442 CC(C)c1oc(=O)oc1COC(=O)[C@@]1(C)[C@@H]2CC[C@]3(C)[C@H](C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CC[C@@]1(C)OC(C)=O InChI=1S/C40H56O10/c1-22(2)29-27(48-33(46)49-29)21-47-32(45)40(10)28-11-12-38(8)30(36(28,6)16-18-39(40,9)50-23(3)41)26(42)19-24-25-20-35(5,31(43)44)14-13-34(25,4)15-17-37(24,38)7/h19,22,25,28,30H,11-18,20-21H2,1-10H3,(H,43,44)/t25-,28+,30+,34+,35-,36-,37+,38+,39+,40+/m0/s1 MTLRBHUTAAKIPX-CDZCQVROSA-N 642886 (2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,10,12a-heptamethyl-13-oxo-9-({[2-oxo-5-(propan-2-yl)-2H-1,3-dioxol-4-yl]methoxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 702-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 398 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642886&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725314 488875729 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362443 CCc1oc(=O)oc1COC(=O)[C@@]1(C)[C@@H]2CC[C@]3(C)[C@H](C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CC[C@@]1(C)OC(C)=O InChI=1S/C39H54O10/c1-10-26-27(48-32(45)47-26)21-46-31(44)39(9)28-11-12-37(7)29(35(28,5)16-18-38(39,8)49-22(2)40)25(41)19-23-24-20-34(4,30(42)43)14-13-33(24,3)15-17-36(23,37)6/h19,24,28-29H,10-18,20-21H2,1-9H3,(H,42,43)/t24-,28+,29+,33+,34-,35-,36+,37+,38+,39+/m0/s1 KSLGBFNYMQWDFX-FJGVVAAVSA-N 642887 (2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(acetyloxy)-9-{[(5-ethyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-2,4a, 6a,6b, 9,10,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 703-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 794 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642887&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 170795498 488875730 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362444 CC(=O)O[C@]1(C)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C38H52O10/c1-21-26(47-31(44)46-21)20-45-30(43)38(9)27-10-11-36(7)28(34(27,5)15-17-37(38,8)48-22(2)39)25(40)18-23-24-19-33(4,29(41)42)13-12-32(24,3)14-16-35(23,36)6/h18,24,27-28H,10-17,19-20H2,1-9H3,(H,41,42)/t24-,27+,28+,32+,33-,34-,35+,36+,37+,38+/m0/s1 QMBCIMQZRFBGEJ-ZHNTXTDWSA-N 642888 (2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,10,12a-heptamethyl-9-{[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 704-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642888&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725371 488875731 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362445 CCc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(C)=O InChI=1S/C38H52O10/c1-9-25-26(48-32(44)47-25)20-45-31(43)38(8)27-10-13-37(7)29(35(27,5)12-11-28(38)46-21(2)39)24(40)18-22-23-19-34(4,30(41)42)15-14-33(23,3)16-17-36(22,37)6/h18,23,27-29H,9-17,19-20H2,1-8H3,(H,41,42)/t23-,27+,28-,29+,33+,34-,35-,36+,37+,38-/m0/s1 QKCSYUHINVKLBW-OQHYTJIBSA-N 642889 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-acetoxy-9-(((5-ethyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 316-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 31.6 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642889&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719247 488875732 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362446 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C(C)(C)C InChI=1S/C40H56O10/c1-22(41)48-28-12-13-37(7)27(40(28,10)32(45)47-21-26-30(34(2,3)4)50-33(46)49-26)11-14-39(9)29(37)25(42)19-23-24-20-36(6,31(43)44)16-15-35(24,5)17-18-38(23,39)8/h19,24,27-29H,11-18,20-21H2,1-10H3,(H,43,44)/t24-,27+,28-,29+,35+,36-,37-,38+,39+,40-/m0/s1 ZEVHLHXMXZSTLE-HRMIHNAESA-N 642890 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(acetyloxy)-9-{[(5-tert-butyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 705-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 251 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642890&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725293 488875733 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362447 CCCc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(C)=O InChI=1S/C39H54O10/c1-9-10-26-27(49-33(45)48-26)21-46-32(44)39(8)28-11-14-38(7)30(36(28,5)13-12-29(39)47-22(2)40)25(41)19-23-24-20-35(4,31(42)43)16-15-34(24,3)17-18-37(23,38)6/h19,24,28-30H,9-18,20-21H2,1-8H3,(H,42,43)/t24-,28+,29-,30+,34+,35-,36-,37+,38+,39-/m0/s1 NJVVUZOCNFGUTC-HJEOHVBSSA-N 642891 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-9-{[(2-oxo-5-propyl-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 706-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 200 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642891&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725398 488875734 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362448 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1-c1ccccc1 InChI=1S/C42H52O10/c1-24(43)50-31-14-15-39(4)30(42(31,7)35(47)49-23-29-32(52-36(48)51-29)25-11-9-8-10-12-25)13-16-41(6)33(39)28(44)21-26-27-22-38(3,34(45)46)18-17-37(27,2)19-20-40(26,41)5/h8-12,21,27,30-31,33H,13-20,22-23H2,1-7H3,(H,45,46)/t27-,30+,31-,33+,37+,38-,39-,40+,41+,42-/m0/s1 HNBOFSRJMJJRGF-RTKJJFNDSA-N 642892 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-9-{[(2-oxo-5-phenyl-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 707-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 79.4 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642892&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725360 488875735 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362449 CC(C)c1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(C)=O InChI=1S/C39H54O10/c1-21(2)29-26(48-33(45)49-29)20-46-32(44)39(9)27-10-13-38(8)30(36(27,6)12-11-28(39)47-22(3)40)25(41)18-23-24-19-35(5,31(42)43)15-14-34(24,4)16-17-37(23,38)7/h18,21,24,27-28,30H,10-17,19-20H2,1-9H3,(H,42,43)/t24-,27+,28-,30+,34+,35-,36-,37+,38+,39-/m0/s1 JOMSMEDNMNTEAF-FTPJZAQLSA-N 642893 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-acetoxy-9-(((5-isopropyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 209-3 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 63.1 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642893&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719250 488875736 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362450 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C37H50O10/c1-20-25(47-31(43)45-20)19-44-30(42)37(8)26-9-12-36(7)28(34(26,5)11-10-27(37)46-21(2)38)24(39)17-22-23-18-33(4,29(40)41)14-13-32(23,3)15-16-35(22,36)6/h17,23,26-28H,9-16,18-19H2,1-8H3,(H,40,41)/t23-,26+,27-,28+,32+,33-,34-,35+,36+,37-/m0/s1 GUXXZWBXDIUDJU-BKACUEHDSA-N 642894 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-Acetoxy-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 243-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 31.6 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642894&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719240 488875737 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362451 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](O)[C@@](C)(COCC(O)=O)C4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O InChI=1S/C32H48O7/c1-27-11-12-28(2,26(37)38)16-20(27)19-15-21(33)25-29(3)9-8-23(34)30(4,18-39-17-24(35)36)22(29)7-10-32(25,6)31(19,5)14-13-27/h15,20,22-23,25,34H,7-14,16-18H2,1-6H3,(H,35,36)(H,37,38)/t20-,22?,23-,25+,27+,28-,29-,30-,31+,32+/m0/s1 HPGITINIUQPHSS-CYIOBJHQSA-N 642895 (2S,4aS,6aS,6bR,9R,10S,12aS,12bR,14bR)-9-[(carboxymethoxy)methyl]-10-hydroxy-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 7-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <10000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642895&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 170795499 488875738 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362452 Cc1oc(=O)oc1COC(=O)COC[C@]1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O InChI=1S/C37H52O10/c1-21-25(47-31(43)46-21)18-45-28(40)19-44-20-35(5)26-8-11-37(7)29(34(26,4)10-9-27(35)39)24(38)16-22-23-17-33(3,30(41)42)13-12-32(23,2)14-15-36(22,37)6/h16,23,26-27,29,39H,8-15,17-20H2,1-7H3,(H,41,42)/t23-,26+,27-,29+,32+,33-,34-,35-,36+,37+/m0/s1 FMRSFJCXLWGOTP-UKEITFJXSA-N 642896 (2S,4aS,6aS,6bR,8aR,9R,10S,12aS,12bR,14bR)-10-Hydroxy-2,4a,6a,6b,9,12a-hexamethyl-9-((2-((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)-2-oxoethoxy)methyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 240-8 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 10000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642896&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719207 488875739 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362453 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)CO)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C32H46O8/c1-27-11-12-28(2,25(36)37)16-19(27)18-15-20(34)24-29(3)9-8-22(40-23(35)17-33)32(6,26(38)39)21(29)7-10-31(24,5)30(18,4)14-13-27/h15,19,21-22,24,33H,7-14,16-17H2,1-6H3,(H,36,37)(H,38,39)/t19-,21+,22-,24+,27+,28-,29-,30+,31+,32-/m0/s1 PNPAYTTXWGSRMV-UIKVJZBOSA-N 642897 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-hydroxyacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 8-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1259 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642897&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146465 488875740 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362454 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CO InChI=1S/C37H50O11/c1-20-24(47-31(44)46-20)19-45-30(43)37(7)25-8-11-36(6)28(34(25,4)10-9-26(37)48-27(40)18-38)23(39)16-21-22-17-33(3,29(41)42)13-12-32(22,2)14-15-35(21,36)5/h16,22,25-26,28,38H,8-15,17-19H2,1-7H3,(H,41,42)/t22-,25+,26-,28+,32+,33-,34-,35+,36+,37-/m0/s1 NSVAPJFEJGMPBG-MWAFZONDSA-N 642898 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(2-Hydroxyacetoxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 244-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 158 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642898&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047360 488875741 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362455 COCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C33H48O8/c1-28-12-13-29(2,26(36)37)17-20(28)19-16-21(34)25-30(3)10-9-23(41-24(35)18-40-7)33(6,27(38)39)22(30)8-11-32(25,5)31(19,4)15-14-28/h16,20,22-23,25H,8-15,17-18H2,1-7H3,(H,36,37)(H,38,39)/t20-,22+,23-,25+,28+,29-,30-,31+,32+,33-/m0/s1 BGDJUKFHIDLDOK-VRZLTMKRSA-N 642899 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-methoxyacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 9-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <10000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642899&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146474 488875742 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362456 COCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C(C)C InChI=1S/C40H56O11/c1-22(2)30-26(49-34(46)51-30)20-48-33(45)40(8)27-10-13-39(7)31(37(27,5)12-11-28(40)50-29(42)21-47-9)25(41)18-23-24-19-36(4,32(43)44)15-14-35(24,3)16-17-38(23,39)6/h18,22,24,27-28,31H,10-17,19-21H2,1-9H3,(H,43,44)/t24-,27+,28-,31+,35+,36-,37-,38+,39+,40-/m0/s1 PWAXHYJDEPOQEW-YYDDGKOJSA-N 642900 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-methoxyacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-9-({[2-oxo-5-(propan-2-yl)-2H-1,3-dioxol-4-yl]methoxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 708-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642900&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047532 488875743 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362457 COCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C38H52O11/c1-21-25(48-32(44)47-21)19-46-31(43)38(7)26-9-12-37(6)29(35(26,4)11-10-27(38)49-28(40)20-45-8)24(39)17-22-23-18-34(3,30(41)42)14-13-33(23,2)15-16-36(22,37)5/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,41,42)/t23-,26+,27-,29+,33+,34-,35-,36+,37+,38-/m0/s1 BWUWEHCRXMNXQJ-DFSFSSLLSA-N 642901 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-methoxyacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-9-{[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 709-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 63.1 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642901&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154678118 488875744 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362458 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OCC(O)=O InChI=1S/C32H48O6/c1-27(2)22-8-11-32(7)25(30(22,5)10-9-23(27)38-18-24(34)35)21(33)16-19-20-17-29(4,26(36)37)13-12-28(20,3)14-15-31(19,32)6/h16,20,22-23,25H,8-15,17-18H2,1-7H3,(H,34,35)(H,36,37)/t20-,22-,23-,25+,28+,29-,30-,31+,32+/m0/s1 VVCUIODSHFTDBF-MXGNSNOLSA-N 642902 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-(carboxymethoxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 10-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3981 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642902&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101756111 488875745 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362459 COCCOCCOCCSCc1oc(=O)oc1COC(=O)CO[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C44H66O12S/c1-39(2)33-9-12-44(7)36(30(45)23-28-29-24-41(4,37(47)48)14-13-40(29,3)15-16-43(28,44)6)42(33,5)11-10-34(39)53-26-35(46)54-25-31-32(56-38(49)55-31)27-57-22-21-52-20-19-51-18-17-50-8/h23,29,33-34,36H,9-22,24-27H2,1-8H3,(H,47,48)/t29-,33-,34-,36+,40+,41-,42-,43+,44+/m0/s1 TXYCGBYCMJZHNK-BCVLISMVSA-N 642903 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-10-(2-oxo-2-{[2-oxo-5-(2,5,8-trioxa-11-thiadodecan-12-yl)-2H-1,3-dioxol-4-yl]methoxy}ethoxy)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 710-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642903&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725395 488875746 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362460 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OCC(=O)OCc1oc(=O)oc1CO InChI=1S/C37H52O10/c1-32(2)26-8-11-37(7)29(23(39)16-21-22-17-34(4,30(41)42)13-12-33(22,3)14-15-36(21,37)6)35(26,5)10-9-27(32)44-20-28(40)45-19-25-24(18-38)46-31(43)47-25/h16,22,26-27,29,38H,8-15,17-20H2,1-7H3,(H,41,42)/t22-,26-,27-,29+,33+,34-,35-,36+,37+/m0/s1 BOIVJURIPDDOFN-IUXXZVLHSA-N 642904 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-(2-{[5-(hydroxymethyl)-2-oxo-2H-1,3-dioxol-4-yl]methoxy}-2-oxoethoxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 711-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1585 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642904&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725409 488875747 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362461 Cc1oc(=O)oc1COC(=O)CO[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C37H52O9/c1-21-25(46-31(42)45-21)19-44-28(39)20-43-27-10-11-35(6)26(32(27,2)3)9-12-37(8)29(35)24(38)17-22-23-18-34(5,30(40)41)14-13-33(23,4)15-16-36(22,37)7/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,40,41)/t23-,26-,27-,29+,33+,34-,35-,36+,37+/m0/s1 AATBKMFAPCFAKE-XTXJVEODSA-N 642905 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-10-{2-[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]-2-oxoethoxy}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 712-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 10000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642905&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047232 488875748 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362462 COC(=O)N[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C32H47NO7/c1-27-12-13-28(2,24(35)36)17-19(27)18-16-20(34)23-29(3)10-9-22(33-26(39)40-7)32(6,25(37)38)21(29)8-11-31(23,5)30(18,4)15-14-27/h16,19,21-23H,8-15,17H2,1-7H3,(H,33,39)(H,35,36)(H,37,38)/t19-,21+,22-,23+,27+,28-,29-,30+,31+,32-/m0/s1 VLXITSRNWWWBMI-HHHFJLFUSA-N 642906 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(methoxycarbonyl)amino]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 11-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <10000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642906&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146472 488875749 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362463 COC(=O)N[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C37H51NO10/c1-20-24(48-31(44)47-20)19-46-29(42)37(7)25-9-12-36(6)27(34(25,4)11-10-26(37)38-30(43)45-8)23(39)17-21-22-18-33(3,28(40)41)14-13-32(22,2)15-16-35(21,36)5/h17,22,25-27H,9-16,18-19H2,1-8H3,(H,38,43)(H,40,41)/t22-,25+,26-,27+,32+,33-,34-,35+,36+,37-/m0/s1 SRMVGWYVYNCWCW-VLCAGPALSA-N 642907 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((methoxycarbonyl)amino)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 281-3 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 200 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642907&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719217 488875750 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362464 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)NCCN5CCOCC5)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C37H56N2O8/c1-32-11-12-33(2,29(41)42)22-24(32)23-21-25(40)28-34(3)9-8-27(47-31(45)38-15-16-39-17-19-46-20-18-39)37(6,30(43)44)26(34)7-10-36(28,5)35(23,4)14-13-32/h21,24,26-28H,7-20,22H2,1-6H3,(H,38,45)(H,41,42)(H,43,44)/t24-,26+,27-,28+,32+,33-,34-,35+,36+,37-/m0/s1 LKKGZEDKNJJDPG-ULRRUDSZSA-N 642908 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-10-({[2-(morpholin-4-yl)ethyl]carbamoyl}oxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 12-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <10000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642908&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146464 488875751 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362465 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)NCCN1CCOCC1 InChI=1S/C42H60N2O11/c1-25-29(54-36(50)53-25)24-52-34(48)42(7)30-8-11-41(6)32(39(30,4)10-9-31(42)55-35(49)43-16-17-44-18-20-51-21-19-44)28(45)22-26-27-23-38(3,33(46)47)13-12-37(27,2)14-15-40(26,41)5/h22,27,30-32H,8-21,23-24H2,1-7H3,(H,43,49)(H,46,47)/t27-,30+,31-,32+,37+,38-,39-,40+,41+,42-/m0/s1 VUXFXBNMZHFXPB-YFVMYGIQSA-N 642909 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(((2-morpholinoethyl)carbamoyl)oxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 286-4 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 126 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642909&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725353 488875752 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362466 CN(C)CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C34H51NO7/c1-29-13-14-30(2,27(38)39)18-21(29)20-17-22(36)26-31(3)11-10-24(42-25(37)19-35(7)8)34(6,28(40)41)23(31)9-12-33(26,5)32(20,4)16-15-29/h17,21,23-24,26H,9-16,18-19H2,1-8H3,(H,38,39)(H,40,41)/t21-,23+,24-,26+,29+,30-,31-,32+,33+,34-/m0/s1 YPJFAVYMJCRYEB-JJIJRNMFSA-N 642910 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-{[2-(dimethylamino)acetyl]oxy}-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 13-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <10000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642910&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146470 488875753 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362467 CN(C)CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C39H55NO10/c1-22-26(49-33(46)48-22)21-47-32(45)39(7)27-10-13-38(6)30(36(27,4)12-11-28(39)50-29(42)20-40(8)9)25(41)18-23-24-19-35(3,31(43)44)15-14-34(24,2)16-17-37(23,38)5/h18,24,27-28,30H,10-17,19-21H2,1-9H3,(H,43,44)/t24-,27+,28-,30+,34+,35-,36-,37+,38+,39-/m0/s1 OSQVQUKCNOSSHE-FTPJZAQLSA-N 642911 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((dimethylglycyl)oxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 290-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 251 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642911&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047338 488875754 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362468 CCOC(=O)c1cnn([C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3C(=O)C=C3[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]43C)C(O)=O)[C@]2(C)C(O)=O)c1OC InChI=1S/C37H52N2O8/c1-9-47-29(41)21-20-38-39(28(21)46-8)26-11-12-34(4)25(37(26,7)31(44)45)10-13-36(6)27(34)24(40)18-22-23-19-33(3,30(42)43)15-14-32(23,2)16-17-35(22,36)5/h18,20,23,25-27H,9-17,19H2,1-8H3,(H,42,43)(H,44,45)/t23-,25+,26-,27+,32+,33-,34-,35+,36+,37-/m0/s1 DCXSPVRVNOOJHM-BHUHDXQKSA-N 642912 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[4-(ethoxycarbonyl)-5-methoxy-1H-pyrazol-1-yl]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 14-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2512 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642912&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 170795500 488875755 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362469 CCOC(=O)c1cnn([C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3C(=O)C=C3[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]43C)C(O)=O)[C@]2(C)C(=O)OCc2oc(=O)oc2C)c1OC InChI=1S/C42H56N2O11/c1-10-52-33(46)24-21-43-44(32(24)51-9)30-12-13-39(5)29(42(30,8)35(49)53-22-28-23(2)54-36(50)55-28)11-14-41(7)31(39)27(45)19-25-26-20-38(4,34(47)48)16-15-37(26,3)17-18-40(25,41)6/h19,21,26,29-31H,10-18,20,22H2,1-9H3,(H,47,48)/t26-,29+,30-,31+,37+,38-,39-,40+,41+,42-/m0/s1 HSJFXFMJSGPMQM-NODWQRKRSA-N 642913 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[4-(ethoxycarbonyl)-5-methoxy-1H-pyrazol-1-yl]-2,4a,6a,6b,9,12a-hexamethyl-9-{[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 713-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 126 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642913&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725281 488875756 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362470 CCCOCCOCCOCCOC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C40H62O11/c1-8-17-47-18-19-48-20-21-49-22-23-50-34(46)51-30-10-11-37(4)29(40(30,7)33(44)45)9-12-39(6)31(37)28(41)24-26-27-25-36(3,32(42)43)14-13-35(27,2)15-16-38(26,39)5/h24,27,29-31H,8-23,25H2,1-7H3,(H,42,43)(H,44,45)/t27-,29+,30-,31+,35+,36-,37-,38+,39+,40-/m0/s1 ZNEWQPQEJZDJJC-YLJNXWOTSA-N 642914 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-10-(2,5,8,11-tetraoxatetradecanoyloxy)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 15-x 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens <10000 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642914&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146473 488875757 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1362471 COCCOCCOCCOCCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(=O)OCc2ccc(c(OCc3cn(OCCOCCOCCOC)nn3)c2)[N+]([O-])=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C62H88N4O21/c1-41-49(86-56(71)85-41)40-83-55(70)62(7)50-12-16-61(6)53(59(50,4)15-13-51(62)87-52(68)14-21-76-26-27-79-30-28-77-24-22-74-8)47(67)35-44-45-36-58(3,18-17-57(45,2)19-20-60(44,61)5)54(69)82-38-42-10-11-46(66(72)73)48(34-42)81-39-43-37-65(64-63-43)84-33-32-80-31-29-78-25-23-75-9/h10-11,34-35,37,45,50-51,53H,12-33,36,38-40H2,1-9H3/t45-,50+,51-,53+,57+,58-,59-,60+,61+,62-/m0/s1 CKQHCSQJNDICOJ-YFQZQLKYSA-N 642915 2-(3-((1-PEG-1H-1,2,3-triazol-4-yl)methoxy)-4-nitrobenzyl) 9-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)(2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((2,5,8,11-tetraoxatetradecan-14-oyl)oxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylate::US11858959, Compound 605-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 126 US Patent 10.7270/Q24B35GS US11858959 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642915&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 170795501 488875758 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51519994 COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+ VFLDPWHFBUODDF-FCXRPNKRSA-N 50140172 CHEBI:3962::CHEMBL140::Curcumin::US9409845, Table 1, Compound 21: curcumin 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 14560 ChEMBL 10.7270/Q2N87G15 32088493 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50140172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50140172&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search CC9 969516 336952476 CHEMBL140 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 51519995 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c1cc(O)c(O)c(O)c1 InChI=1S/C22H18O11/c23-10-5-12(24)11-7-18(33-22(31)9-3-15(27)20(30)16(28)4-9)21(32-17(11)6-10)8-1-13(25)19(29)14(26)2-8/h1-6,18,21,23-30H,7H2/t18-,21-/m1/s1 WMBWREPUVVBILR-WIYYLYMNSA-N 50070942 (-)-Epigallocatechin gallate::(-)-Epigallocatechin-3-o-gallate::(-)-epigallocatechin 3-gallate::(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate::CHEMBL297453::EGCG::Epigallocatechin 3-gallate::Epigallocatechin monogallate, B::cid_65064 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 20930 ChEMBL 10.7270/Q2N87G15 32088493 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50070942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50070942&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search EGG 65064 103964753 4806 CHEMBL297453 7002 C09731 ZINC03870412 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426027 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)C(O)=O InChI=1S/C31H46O5/c1-26(2)18(24(33)34)8-10-29(5)22(26)9-11-31(7)23(29)21(32)16-19-20-17-28(4,25(35)36)13-12-27(20,3)14-15-30(19,31)6/h16,18,20,22-23H,8-15,17H2,1-7H3,(H,33,34)(H,35,36)/t18-,20+,22+,23-,27-,28+,29+,30-,31-/m1/s1 ACNQSEAJFQHYLI-LEYZWCBYSA-N 642870 (2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,10-dicarboxylic acid::US11858959, Compound 1-5::US20240209019, Compound noid1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3162 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642870&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 138502321 488875713 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426028 CC1OC(=O)OC1COC(=O)[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C36H52O8/c1-20-25(44-30(41)43-20)19-42-28(38)21-9-11-34(6)26(31(21,2)3)10-12-36(8)27(34)24(37)17-22-23-18-33(5,29(39)40)14-13-32(23,4)15-16-35(22,36)7/h17,20-21,23,25-27H,9-16,18-19H2,1-8H3,(H,39,40)/t20?,21-,23+,25?,26+,27-,32-,33+,34+,35-,36-/m1/s1 IONPZJFPSBVQNQ-PTTLPNFESA-N 683054 (2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-Heptamethyl-10-(((5-methyl-2-oxo-1,3-dioxolan-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US20240209019, Compound 178-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent 10.7270/Q2TF02NW US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=683054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=683054&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725268 503272456 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426029 Cc1oc(=O)oc1COC(=O)[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C36H50O8/c1-20-25(44-30(41)43-20)19-42-28(38)21-9-11-34(6)26(31(21,2)3)10-12-36(8)27(34)24(37)17-22-23-18-33(5,29(39)40)14-13-32(23,4)15-16-35(22,36)7/h17,21,23,26-27H,9-16,18-19H2,1-8H3,(H,39,40)/t21-,23+,26+,27-,32-,33+,34+,35-,36-/m1/s1 NYSNZQFPZLMDBT-LPRQLXAWSA-N 642872 (2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-Heptamethyl-10-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 176-2::US20240209019, Compound 176-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642872&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719197 488875715 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426030 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](C(=O)OCC5COC(=O)O5)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O InChI=1S/C35H50O8/c1-30(2)21(27(37)41-18-20-19-42-29(40)43-20)8-10-33(5)25(30)9-11-35(7)26(33)24(36)16-22-23-17-32(4,28(38)39)13-12-31(23,3)14-15-34(22,35)6/h16,20-21,23,25-26H,8-15,17-19H2,1-7H3,(H,38,39)/t20?,21-,23+,25+,26-,31-,32+,33+,34-,35-/m1/s1 XKENMTWDQUOPBK-QAKAGYLFSA-N 642873 (2S,4aS,6aS,6bR,8aS,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-10-{[(2-oxo-1,3-dioxolan-4-yl)methoxy]carbonyl}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 700-1::US20240209019, Compound 700-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 794 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642873&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725392 488875716 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426031 CSCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C33H48O7S/c1-28-12-13-29(2,26(36)37)17-20(28)19-16-21(34)25-30(3)10-9-23(40-24(35)18-41-7)33(6,27(38)39)22(30)8-11-32(25,5)31(19,4)15-14-28/h16,20,22-23,25H,8-15,17-18H2,1-7H3,(H,36,37)(H,38,39)/t20-,22+,23-,25+,28+,29-,30-,31+,32+,33-/m0/s1 SJXFUSLUZVBZBF-VRZLTMKRSA-N 642874 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-10-{[2-(methylsulfanyl)acetyl]oxy}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 1-x::US20240209019, Compound noid2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3981 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642874&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146469 488875717 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426032 CSCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C38H52O10S/c1-21-25(47-32(44)46-21)19-45-31(43)38(7)26-9-12-37(6)29(35(26,4)11-10-27(38)48-28(40)20-49-8)24(39)17-22-23-18-34(3,30(41)42)14-13-33(23,2)15-16-36(22,37)5/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,41,42)/t23-,26+,27-,29+,33+,34-,35-,36+,37+,38-/m0/s1 CAGVAYFDLRIYPB-DFSFSSLLSA-N 642875 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-Hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(2-(methylthio)acetoxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 194-10::US20240209019, Compound 194-10 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 10.0 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642875&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719239 488875718 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426033 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CS(C)(=O)=O InChI=1S/C38H52O12S/c1-21-25(49-32(44)48-21)19-47-31(43)38(7)26-9-12-37(6)29(35(26,4)11-10-27(38)50-28(40)20-51(8,45)46)24(39)17-22-23-18-34(3,30(41)42)14-13-33(23,2)15-16-36(22,37)5/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,41,42)/t23-,26+,27-,29+,33+,34-,35-,36+,37+,38-/m0/s1 AZVXLLRFDOEERV-DFSFSSLLSA-N 642876 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-Hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(2-(methyl sulfonyl)acetoxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 195-2::US20240209019, Compound 195-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642876&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719241 488875719 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426034 CSCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C(C)C InChI=1S/C40H56O10S/c1-22(2)30-26(48-34(46)50-30)20-47-33(45)40(8)27-10-13-39(7)31(37(27,5)12-11-28(40)49-29(42)21-51-9)25(41)18-23-24-19-36(4,32(43)44)15-14-35(24,3)16-17-38(23,39)6/h18,22,24,27-28,31H,10-17,19-21H2,1-9H3,(H,43,44)/t24-,27+,28-,31+,35+,36-,37-,38+,39+,40-/m0/s1 WTEMXJJQNQSDJG-YYDDGKOJSA-N 642877 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-10-{[2-(methylsulfanyl)acetyl]oxy}-13-oxo-9-({[2-oxo-5-(propan-2-yl)-2H-1,3-dioxol-4-yl]methoxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 701-1::US20240209019, Compound 701-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 100 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642877&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725362 488875720 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426035 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)CS(C)(=O)=O)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C33H48O9S/c1-28-12-13-29(2,26(36)37)17-20(28)19-16-21(34)25-30(3)10-9-23(42-24(35)18-43(7,40)41)33(6,27(38)39)22(30)8-11-32(25,5)31(19,4)15-14-28/h16,20,22-23,25H,8-15,17-18H2,1-7H3,(H,36,37)(H,38,39)/t20-,22+,23-,25+,28+,29-,30-,31+,32+,33-/m0/s1 QOFWOGQUMUMZNR-VRZLTMKRSA-N 642878 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-methanesulfonylacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 2-x::US20240209019, Compound noid3 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642878&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146471 488875721 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426036 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CS(C)(=O)=O InChI=1S/C38H52O12S/c1-21-25(49-32(44)48-21)19-47-31(43)38(7)26-9-12-37(6)29(35(26,4)11-10-27(38)50-28(40)20-51(8,45)46)24(39)17-22-23-18-34(3,30(41)42)14-13-33(23,2)15-16-36(22,37)5/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,41,42)/t23-,26+,27-,29+,33+,34-,35-,36+,37+,38-/m0/s1 AZVXLLRFDOEERV-DFSFSSLLSA-N 642876 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-Hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(2-(methyl sulfonyl)acetoxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 195-2::US20240209019, Compound 195-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642876&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719241 488875719 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426037 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)c5ccccc5)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C37H48O7/c1-32-16-17-33(2,30(40)41)21-24(32)23-20-25(38)28-34(3)14-13-27(44-29(39)22-10-8-7-9-11-22)37(6,31(42)43)26(34)12-15-36(28,5)35(23,4)19-18-32/h7-11,20,24,26-28H,12-19,21H2,1-6H3,(H,40,41)(H,42,43)/t24-,26+,27-,28+,32+,33-,34-,35+,36+,37-/m0/s1 IGFUDYNRGRBXOG-ULRRUDSZSA-N 642879 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(benzoyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 3-x::US20240209019, Compound noid4 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 251 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642879&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 170795497 488875722 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426038 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)c1ccccc1 InChI=1S/C42H52O10/c1-24-29(51-36(48)50-24)23-49-35(47)42(7)30-13-16-41(6)32(39(30,4)15-14-31(42)52-33(44)25-11-9-8-10-12-25)28(43)21-26-27-22-38(3,34(45)46)18-17-37(27,2)19-20-40(26,41)5/h8-12,21,27,30-32H,13-20,22-23H2,1-7H3,(H,45,46)/t27-,30+,31-,32+,37+,38-,39-,40+,41+,42-/m0/s1 KRNTZYPJGFOJQY-YFVMYGIQSA-N 642880 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(Benzoyloxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 197-2::US20240209019, Compound 197-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 12.6 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642880&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047258 488875723 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426039 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)C5CC5)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C34H48O7/c1-29-13-14-30(2,27(37)38)18-21(29)20-17-22(35)25-31(3)11-10-24(41-26(36)19-7-8-19)34(6,28(39)40)23(31)9-12-33(25,5)32(20,4)16-15-29/h17,19,21,23-25H,7-16,18H2,1-6H3,(H,37,38)(H,39,40)/t21-,23+,24-,25+,29+,30-,31-,32+,33+,34-/m0/s1 ILKKJBFAAPQKDB-CATRINGESA-N 642881 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(cyclopropanecarbonyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 4-x::US20240209019, Compound noid5 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1585 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642881&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146468 488875724 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426040 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)C1CC1 InChI=1S/C39H52O10/c1-21-26(48-33(45)47-21)20-46-32(44)39(7)27-10-13-38(6)29(36(27,4)12-11-28(39)49-30(41)22-8-9-22)25(40)18-23-24-19-35(3,31(42)43)15-14-34(24,2)16-17-37(23,38)5/h18,22,24,27-29H,8-17,19-20H2,1-7H3,(H,42,43)/t24-,27+,28-,29+,34+,35-,36-,37+,38+,39-/m0/s1 KNTXPMCWIUDXLY-MKYWAOEHSA-N 642882 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((Cyclopropanecarbonyl)oxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 198-2::US20240209019, Compound 198-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 20.0 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642882&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719234 488875725 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426041 COCO[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C32H48O7/c1-27-12-13-28(2,25(34)35)17-20(27)19-16-21(33)24-29(3)10-9-23(39-18-38-7)32(6,26(36)37)22(29)8-11-31(24,5)30(19,4)15-14-27/h16,20,22-24H,8-15,17-18H2,1-7H3,(H,34,35)(H,36,37)/t20-,22+,23-,24+,27+,28-,29-,30+,31+,32-/m0/s1 XCVZFAOFJNWMLX-YWRAXVRTSA-N 642883 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(methoxymethoxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 5-x::US20240209019, Compound noid6 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 7943 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642883&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146467 488875726 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426042 COCO[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C37H52O10/c1-21-25(47-31(42)46-21)19-44-30(41)37(7)26-9-12-36(6)28(34(26,4)11-10-27(37)45-20-43-8)24(38)17-22-23-18-33(3,29(39)40)14-13-32(23,2)15-16-35(22,36)5/h17,23,26-28H,9-16,18-20H2,1-8H3,(H,39,40)/t23-,26+,27-,28+,32+,33-,34-,35+,36+,37-/m0/s1 IRIIXTVQPFXSMZ-BKACUEHDSA-N 642884 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(Methoxymethoxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 205-2::US20240209019, Compound 205-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 398 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642884&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719266 488875727 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426043 COCO[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C(C)C InChI=1S/C39H56O10/c1-22(2)29-26(48-33(44)49-29)20-46-32(43)39(8)27-10-13-38(7)30(36(27,5)12-11-28(39)47-21-45-9)25(40)18-23-24-19-35(4,31(41)42)15-14-34(24,3)16-17-37(23,38)6/h18,22,24,27-28,30H,10-17,19-21H2,1-9H3,(H,41,42)/t24-,27+,28-,30+,34+,35-,36-,37+,38+,39-/m0/s1 YCPGFQMZTIGSAH-FTPJZAQLSA-N 683068 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-9-(((5-Isopropyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(methoxymethoxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US20240209019, Compound 258-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 126 US Patent 10.7270/Q2TF02NW US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=683068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=683068&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154678144 503272469 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426044 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C32H46O7/c1-18(33)39-23-9-10-29(4)22(32(23,7)26(37)38)8-11-31(6)24(29)21(34)16-19-20-17-28(3,25(35)36)13-12-27(20,2)14-15-30(19,31)5/h16,20,22-24H,8-15,17H2,1-7H3,(H,35,36)(H,37,38)/t20-,22+,23-,24+,27+,28-,29-,30+,31+,32-/m0/s1 LGXOVMBLQAXCGN-YWRAXVRTSA-N 642885 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 6-x::US20240209019, Compound noid7 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1259 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642885&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719210 488875728 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426045 CC(C)c1oc(=O)oc1COC(=O)[C@@]1(C)[C@@H]2CC[C@]3(C)[C@H](C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CC[C@@]1(C)OC(C)=O InChI=1S/C40H56O10/c1-22(2)29-27(48-33(46)49-29)21-47-32(45)40(10)28-11-12-38(8)30(36(28,6)16-18-39(40,9)50-23(3)41)26(42)19-24-25-20-35(5,31(43)44)14-13-34(25,4)15-17-37(24,38)7/h19,22,25,28,30H,11-18,20-21H2,1-10H3,(H,43,44)/t25-,28+,30+,34+,35-,36-,37+,38+,39+,40+/m0/s1 MTLRBHUTAAKIPX-CDZCQVROSA-N 642886 (2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,10,12a-heptamethyl-13-oxo-9-({[2-oxo-5-(propan-2-yl)-2H-1,3-dioxol-4-yl]methoxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 702-1::US20240209019, Compound 702-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 398 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642886&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725314 488875729 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426046 CCc1oc(=O)oc1COC(=O)[C@@]1(C)[C@@H]2CC[C@]3(C)[C@H](C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O)[C@@]2(C)CC[C@@]1(C)OC(C)=O InChI=1S/C39H54O10/c1-10-26-27(48-32(45)47-26)21-46-31(44)39(9)28-11-12-37(7)29(35(28,5)16-18-38(39,8)49-22(2)40)25(41)19-23-24-20-34(4,30(42)43)14-13-33(24,3)15-17-36(23,37)6/h19,24,28-29H,10-18,20-21H2,1-9H3,(H,42,43)/t24-,28+,29+,33+,34-,35-,36+,37+,38+,39+/m0/s1 KSLGBFNYMQWDFX-FJGVVAAVSA-N 642887 (2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(acetyloxy)-9-{[(5-ethyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-2,4a, 6a,6b, 9,10,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 703-1::US20240209019, Compound 703-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 794 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642887&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 170795498 488875730 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426047 CC(=O)O[C@]1(C)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C38H52O10/c1-21-26(47-31(44)46-21)20-45-30(43)38(9)27-10-11-36(7)28(34(27,5)15-17-37(38,8)48-22(2)39)25(40)18-23-24-19-33(4,29(41)42)13-12-32(24,3)14-16-35(23,36)6/h18,24,27-28H,10-17,19-20H2,1-9H3,(H,41,42)/t24-,27+,28+,32+,33-,34-,35+,36+,37+,38+/m0/s1 QMBCIMQZRFBGEJ-ZHNTXTDWSA-N 642888 (2S,4aS,6aS,6bR,8aR,9S,10R,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,10,12a-heptamethyl-9-{[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 704-1::US20240209019, Compound 704-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642888&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725371 488875731 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426048 CCc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(C)=O InChI=1S/C38H52O10/c1-9-25-26(48-32(44)47-25)20-45-31(43)38(8)27-10-13-37(7)29(35(27,5)12-11-28(38)46-21(2)39)24(40)18-22-23-19-34(4,30(41)42)15-14-33(23,3)16-17-36(22,37)6/h18,23,27-29H,9-17,19-20H2,1-8H3,(H,41,42)/t23-,27+,28-,29+,33+,34-,35-,36+,37+,38-/m0/s1 QKCSYUHINVKLBW-OQHYTJIBSA-N 642889 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-acetoxy-9-(((5-ethyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 316-1::US20240209019, Compound 316-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 31.6 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642889&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719247 488875732 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426049 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C(C)(C)C InChI=1S/C40H56O10/c1-22(41)48-28-12-13-37(7)27(40(28,10)32(45)47-21-26-30(34(2,3)4)50-33(46)49-26)11-14-39(9)29(37)25(42)19-23-24-20-36(6,31(43)44)16-15-35(24,5)17-18-38(23,39)8/h19,24,27-29H,11-18,20-21H2,1-10H3,(H,43,44)/t24-,27+,28-,29+,35+,36-,37-,38+,39+,40-/m0/s1 ZEVHLHXMXZSTLE-HRMIHNAESA-N 642890 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(acetyloxy)-9-{[(5-tert-butyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 705-1::US20240209019, Compound 705-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 251 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642890&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725293 488875733 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426050 CCCc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(C)=O InChI=1S/C39H54O10/c1-9-10-26-27(49-33(45)48-26)21-46-32(44)39(8)28-11-14-38(7)30(36(28,5)13-12-29(39)47-22(2)40)25(41)19-23-24-20-35(4,31(42)43)16-15-34(24,3)17-18-37(23,38)6/h19,24,28-30H,9-18,20-21H2,1-8H3,(H,42,43)/t24-,28+,29-,30+,34+,35-,36-,37+,38+,39-/m0/s1 NJVVUZOCNFGUTC-HJEOHVBSSA-N 642891 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-9-{[(2-oxo-5-propyl-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 706-1::US20240209019, Compound 706-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 200 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642891&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725398 488875734 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426051 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1-c1ccccc1 InChI=1S/C42H52O10/c1-24(43)50-31-14-15-39(4)30(42(31,7)35(47)49-23-29-32(52-36(48)51-29)25-11-9-8-10-12-25)13-16-41(6)33(39)28(44)21-26-27-22-38(3,34(45)46)18-17-37(27,2)19-20-40(26,41)5/h8-12,21,27,30-31,33H,13-20,22-23H2,1-7H3,(H,45,46)/t27-,30+,31-,33+,37+,38-,39-,40+,41+,42-/m0/s1 HNBOFSRJMJJRGF-RTKJJFNDSA-N 642892 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(acetyloxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-9-{[(2-oxo-5-phenyl-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 707-1::US20240209019, Compound 707-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 79.4 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642892&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725360 488875735 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426052 CC(C)c1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(C)=O InChI=1S/C39H54O10/c1-21(2)29-26(48-33(45)49-29)20-46-32(44)39(9)27-10-13-38(8)30(36(27,6)12-11-28(39)47-22(3)40)25(41)18-23-24-19-35(5,31(42)43)15-14-34(24,4)16-17-37(23,38)7/h18,21,24,27-28,30H,10-17,19-20H2,1-9H3,(H,42,43)/t24-,27+,28-,30+,34+,35-,36-,37+,38+,39-/m0/s1 JOMSMEDNMNTEAF-FTPJZAQLSA-N 642893 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-acetoxy-9-(((5-isopropyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 209-3::US20240209019, Compound 209-3 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 63.1 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642893&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719250 488875736 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426053 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C37H50O10/c1-20-25(47-31(43)45-20)19-44-30(42)37(8)26-9-12-36(7)28(34(26,5)11-10-27(37)46-21(2)38)24(39)17-22-23-18-33(4,29(40)41)14-13-32(23,3)15-16-35(22,36)6/h17,23,26-28H,9-16,18-19H2,1-8H3,(H,40,41)/t23-,26+,27-,28+,32+,33-,34-,35+,36+,37-/m0/s1 GUXXZWBXDIUDJU-BKACUEHDSA-N 642894 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-Acetoxy-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 243-1::US20240209019, Compound 243-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 31.6 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642894&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719240 488875737 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426054 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](O)[C@@](C)(COCC(O)=O)C4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O InChI=1S/C32H48O7/c1-27-11-12-28(2,26(37)38)16-20(27)19-15-21(33)25-29(3)9-8-23(34)30(4,18-39-17-24(35)36)22(29)7-10-32(25,6)31(19,5)14-13-27/h15,20,22-23,25,34H,7-14,16-18H2,1-6H3,(H,35,36)(H,37,38)/t20-,22?,23-,25+,27+,28-,29-,30-,31+,32+/m0/s1 HPGITINIUQPHSS-CYIOBJHQSA-N 642895 (2S,4aS,6aS,6bR,9R,10S,12aS,12bR,14bR)-9-[(carboxymethoxy)methyl]-10-hydroxy-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 7-x::US20240209019, Compound noid8 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642895&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 170795499 488875738 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426055 Cc1oc(=O)oc1COC(=O)COC[C@]1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O InChI=1S/C37H52O10/c1-21-25(47-31(43)46-21)18-45-28(40)19-44-20-35(5)26-8-11-37(7)29(34(26,4)10-9-27(35)39)24(38)16-22-23-17-33(3,30(41)42)13-12-32(23,2)14-15-36(22,37)6/h16,23,26-27,29,39H,8-15,17-20H2,1-7H3,(H,41,42)/t23-,26+,27-,29+,32+,33-,34-,35-,36+,37+/m0/s1 FMRSFJCXLWGOTP-UKEITFJXSA-N 642896 (2S,4aS,6aS,6bR,8aR,9R,10S,12aS,12bR,14bR)-10-Hydroxy-2,4a,6a,6b,9,12a-hexamethyl-9-((2-((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)-2-oxoethoxy)methyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 240-8::US20240209019, Compound 240-8 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 10000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642896&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719207 488875739 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426056 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)CO)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C32H46O8/c1-27-11-12-28(2,25(36)37)16-19(27)18-15-20(34)24-29(3)9-8-22(40-23(35)17-33)32(6,26(38)39)21(29)7-10-31(24,5)30(18,4)14-13-27/h15,19,21-22,24,33H,7-14,16-17H2,1-6H3,(H,36,37)(H,38,39)/t19-,21+,22-,24+,27+,28-,29-,30+,31+,32-/m0/s1 PNPAYTTXWGSRMV-UIKVJZBOSA-N 642897 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-hydroxyacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 8-x::US20240209019, Compound noid9 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1259 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642897&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146465 488875740 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426057 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CO InChI=1S/C37H50O11/c1-20-24(47-31(44)46-20)19-45-30(43)37(7)25-8-11-36(6)28(34(25,4)10-9-26(37)48-27(40)18-38)23(39)16-21-22-17-33(3,29(41)42)13-12-32(22,2)14-15-35(21,36)5/h16,22,25-26,28,38H,8-15,17-19H2,1-7H3,(H,41,42)/t22-,25+,26-,28+,32+,33-,34-,35+,36+,37-/m0/s1 NSVAPJFEJGMPBG-MWAFZONDSA-N 642898 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-(2-Hydroxyacetoxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 244-1::US20240209019, Compound 244-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 158 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642898&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047360 488875741 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426058 COCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C33H48O8/c1-28-12-13-29(2,26(36)37)17-20(28)19-16-21(34)25-30(3)10-9-23(41-24(35)18-40-7)33(6,27(38)39)22(30)8-11-32(25,5)31(19,4)15-14-28/h16,20,22-23,25H,8-15,17-18H2,1-7H3,(H,36,37)(H,38,39)/t20-,22+,23-,25+,28+,29-,30-,31+,32+,33-/m0/s1 BGDJUKFHIDLDOK-VRZLTMKRSA-N 642899 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-methoxyacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 9-x::US20240209019, Compound noid10 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642899&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146474 488875742 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426059 COCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C(C)C InChI=1S/C40H56O11/c1-22(2)30-26(49-34(46)51-30)20-48-33(45)40(8)27-10-13-39(7)31(37(27,5)12-11-28(40)50-29(42)21-47-9)25(41)18-23-24-19-36(4,32(43)44)15-14-35(24,3)16-17-38(23,39)6/h18,22,24,27-28,31H,10-17,19-21H2,1-9H3,(H,43,44)/t24-,27+,28-,31+,35+,36-,37-,38+,39+,40-/m0/s1 PWAXHYJDEPOQEW-YYDDGKOJSA-N 642900 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-methoxyacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-9-({[2-oxo-5-(propan-2-yl)-2H-1,3-dioxol-4-yl]methoxy}carbonyl)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 708-1::US20240209019, Compound 708-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 501 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642900&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047532 488875743 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426060 COCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C38H52O11/c1-21-25(48-32(44)47-21)19-46-31(43)38(7)26-9-12-37(6)29(35(26,4)11-10-27(38)49-28(40)20-45-8)24(39)17-22-23-18-34(3,30(41)42)14-13-33(23,2)15-16-36(22,37)5/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,41,42)/t23-,26+,27-,29+,33+,34-,35-,36+,37+,38-/m0/s1 BWUWEHCRXMNXQJ-DFSFSSLLSA-N 642901 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(2-methoxyacetyl)oxy]-2,4a,6a,6b,9,12a-hexamethyl-9-{[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 709-1::US20240209019, Compound 709-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 63.1 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642901&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 154678118 488875744 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426061 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OCC(O)=O InChI=1S/C32H48O6/c1-27(2)22-8-11-32(7)25(30(22,5)10-9-23(27)38-18-24(34)35)21(33)16-19-20-17-29(4,26(36)37)13-12-28(20,3)14-15-31(19,32)6/h16,20,22-23,25H,8-15,17-18H2,1-7H3,(H,34,35)(H,36,37)/t20-,22-,23-,25+,28+,29-,30-,31+,32+/m0/s1 VVCUIODSHFTDBF-MXGNSNOLSA-N 642902 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-(carboxymethoxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 10-x::US20240209019, Compound noid11 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 3981 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642902&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 101756111 488875745 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426062 COCCOCCOCCSCc1oc(=O)oc1COC(=O)CO[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C44H66O12S/c1-39(2)33-9-12-44(7)36(30(45)23-28-29-24-41(4,37(47)48)14-13-40(29,3)15-16-43(28,44)6)42(33,5)11-10-34(39)53-26-35(46)54-25-31-32(56-38(49)55-31)27-57-22-21-52-20-19-51-18-17-50-8/h23,29,33-34,36H,9-22,24-27H2,1-8H3,(H,47,48)/t29-,33-,34-,36+,40+,41-,42-,43+,44+/m0/s1 TXYCGBYCMJZHNK-BCVLISMVSA-N 642903 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-10-(2-oxo-2-{[2-oxo-5-(2,5,8-trioxa-11-thiadodecan-12-yl)-2H-1,3-dioxol-4-yl]methoxy}ethoxy)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 710-1::US20240209019, Compound 710-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642903&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725395 488875746 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426063 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OCC(=O)OCc1oc(=O)oc1CO InChI=1S/C37H52O10/c1-32(2)26-8-11-37(7)29(23(39)16-21-22-17-34(4,30(41)42)13-12-33(22,3)14-15-36(21,37)6)35(26,5)10-9-27(32)44-20-28(40)45-19-25-24(18-38)46-31(43)47-25/h16,22,26-27,29,38H,8-15,17-20H2,1-7H3,(H,41,42)/t22-,26-,27-,29+,33+,34-,35-,36+,37+/m0/s1 BOIVJURIPDDOFN-IUXXZVLHSA-N 642904 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-(2-{[5-(hydroxymethyl)-2-oxo-2H-1,3-dioxol-4-yl]methoxy}-2-oxoethoxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 711-1::US20240209019, Compound 711-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 1585 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642904&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725409 488875747 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426064 Cc1oc(=O)oc1COC(=O)CO[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)C1(C)C InChI=1S/C37H52O9/c1-21-25(46-31(42)45-21)19-44-28(39)20-43-27-10-11-35(6)26(32(27,2)3)9-12-37(8)29(35)24(38)17-22-23-18-34(5,30(40)41)14-13-33(23,4)15-16-36(22,37)7/h17,23,26-27,29H,9-16,18-20H2,1-8H3,(H,40,41)/t23-,26-,27-,29+,33+,34-,35-,36+,37+/m0/s1 AATBKMFAPCFAKE-XTXJVEODSA-N 642905 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-10-{2-[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]-2-oxoethoxy}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 712-1::US20240209019, Compound 712-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 10000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642905&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047232 488875748 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426065 COC(=O)N[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C32H47NO7/c1-27-12-13-28(2,24(35)36)17-19(27)18-16-20(34)23-29(3)10-9-22(33-26(39)40-7)32(6,25(37)38)21(29)8-11-31(23,5)30(18,4)15-14-27/h16,19,21-23H,8-15,17H2,1-7H3,(H,33,39)(H,35,36)(H,37,38)/t19-,21+,22-,23+,27+,28-,29-,30+,31+,32-/m0/s1 VLXITSRNWWWBMI-HHHFJLFUSA-N 642906 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[(methoxycarbonyl)amino]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 11-x::US20240209019, Compound noid12 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642906&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146472 488875749 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426066 COC(=O)N[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C37H51NO10/c1-20-24(48-31(44)47-20)19-46-29(42)37(7)25-9-12-36(6)27(34(25,4)11-10-26(37)38-30(43)45-8)23(39)17-21-22-18-33(3,28(40)41)14-13-32(22,2)15-16-35(21,36)5/h17,22,25-27H,9-16,18-19H2,1-8H3,(H,38,43)(H,40,41)/t22-,25+,26-,27+,32+,33-,34-,35+,36+,37-/m0/s1 SRMVGWYVYNCWCW-VLCAGPALSA-N 642907 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((methoxycarbonyl)amino)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 281-3::US20240209019, Compound 281-3 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 200 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642907&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 162719217 488875750 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426067 C[C@]12CC[C@@](C)(C[C@H]1C1=CC(=O)[C@@H]3[C@@]4(C)CC[C@H](OC(=O)NCCN5CCOCC5)[C@](C)([C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(O)=O)C(O)=O InChI=1S/C37H56N2O8/c1-32-11-12-33(2,29(41)42)22-24(32)23-21-25(40)28-34(3)9-8-27(47-31(45)38-15-16-39-17-19-46-20-18-39)37(6,30(43)44)26(34)7-10-36(28,5)35(23,4)14-13-32/h21,24,26-28H,7-20,22H2,1-6H3,(H,38,45)(H,41,42)(H,43,44)/t24-,26+,27-,28+,32+,33-,34-,35+,36+,37-/m0/s1 LKKGZEDKNJJDPG-ULRRUDSZSA-N 642908 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-10-({[2-(morpholin-4-yl)ethyl]carbamoyl}oxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 12-x::US20240209019, Compound noid13 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642908&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146464 488875751 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426068 Cc1oc(=O)oc1COC(=O)[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)NCCN1CCOCC1 InChI=1S/C42H60N2O11/c1-25-29(54-36(50)53-25)24-52-34(48)42(7)30-8-11-41(6)32(39(30,4)10-9-31(42)55-35(49)43-16-17-44-18-20-51-21-19-44)28(45)22-26-27-23-38(3,33(46)47)13-12-37(27,2)14-15-40(26,41)5/h22,27,30-32H,8-21,23-24H2,1-7H3,(H,43,49)(H,46,47)/t27-,30+,31-,32+,37+,38-,39-,40+,41+,42-/m0/s1 VUXFXBNMZHFXPB-YFVMYGIQSA-N 642909 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-10-(((2-morpholinoethyl)carbamoyl)oxy)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 286-4::US20240209019, Compound 286-4 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 126 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642909&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725353 488875752 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426069 CN(C)CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C34H51NO7/c1-29-13-14-30(2,27(38)39)18-21(29)20-17-22(36)26-31(3)11-10-24(42-25(37)19-35(7)8)34(6,28(40)41)23(31)9-12-33(26,5)32(20,4)16-15-29/h17,21,23-24,26H,9-16,18-19H2,1-8H3,(H,38,39)(H,40,41)/t21-,23+,24-,26+,29+,30-,31-,32+,33+,34-/m0/s1 YPJFAVYMJCRYEB-JJIJRNMFSA-N 642910 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-{[2-(dimethylamino)acetyl]oxy}-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 13-x::US20240209019, Compound noid14 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642910&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146470 488875753 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426070 CN(C)CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C39H55NO10/c1-22-26(49-33(46)48-22)21-47-32(45)39(7)27-10-13-38(6)30(36(27,4)12-11-28(39)50-29(42)20-40(8)9)25(41)18-23-24-19-35(3,31(43)44)15-14-34(24,2)16-17-37(23,38)5/h18,24,27-28,30H,10-17,19-21H2,1-9H3,(H,43,44)/t24-,27+,28-,30+,34+,35-,36-,37+,38+,39-/m0/s1 OSQVQUKCNOSSHE-FTPJZAQLSA-N 642911 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((dimethylglycyl)oxy)-2,4a,6a,6b,9,12a-hexamethyl-9-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic Acid::US11858959, Compound 290-2::US20240209019, Compound 290-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 251 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642911&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 155047338 488875754 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426071 CCOC(=O)c1cnn([C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3C(=O)C=C3[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]43C)C(O)=O)[C@]2(C)C(O)=O)c1OC InChI=1S/C37H52N2O8/c1-9-47-29(41)21-20-38-39(28(21)46-8)26-11-12-34(4)25(37(26,7)31(44)45)10-13-36(6)27(34)24(40)18-22-23-19-33(3,30(42)43)15-14-32(23,2)16-17-35(22,36)5/h18,20,23,25-27H,9-17,19H2,1-8H3,(H,42,43)(H,44,45)/t23-,25+,26-,27+,32+,33-,34-,35+,36+,37-/m0/s1 DCXSPVRVNOOJHM-BHUHDXQKSA-N 642912 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[4-(ethoxycarbonyl)-5-methoxy-1H-pyrazol-1-yl]-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 14-x::US20240209019, Compound noid15 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 2512 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642912&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 170795500 488875755 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426072 CCOC(=O)c1cnn([C@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3C(=O)C=C3[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]43C)C(O)=O)[C@]2(C)C(=O)OCc2oc(=O)oc2C)c1OC InChI=1S/C42H56N2O11/c1-10-52-33(46)24-21-43-44(32(24)51-9)30-12-13-39(5)29(42(30,8)35(49)53-22-28-23(2)54-36(50)55-28)11-14-41(7)31(39)27(45)19-25-26-20-38(4,34(47)48)16-15-37(26,3)17-18-40(25,41)6/h19,21,26,29-31H,10-18,20,22H2,1-9H3,(H,47,48)/t26-,29+,30-,31+,37+,38-,39-,40+,41+,42-/m0/s1 HSJFXFMJSGPMQM-NODWQRKRSA-N 642913 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-[4-(ethoxycarbonyl)-5-methoxy-1H-pyrazol-1-yl]-2,4a,6a,6b,9,12a-hexamethyl-9-{[(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methoxy]carbonyl}-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid::US11858959, Compound 713-1::US20240209019, Compound 713-1 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 126 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642913&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 164725281 488875756 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426073 CCCOCCOCCOCCOC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(O)=O)[C@]1(C)C(O)=O InChI=1S/C40H62O11/c1-8-17-47-18-19-48-20-21-49-22-23-50-34(46)51-30-10-11-37(4)29(40(30,7)33(44)45)9-12-39(6)31(37)28(41)24-26-27-25-36(3,32(42)43)14-13-35(27,2)15-16-38(26,39)5/h24,27,29-31H,8-23,25H2,1-7H3,(H,42,43)(H,44,45)/t27-,29+,30-,31+,35+,36-,37-,38+,39+,40-/m0/s1 ZNEWQPQEJZDJJC-YLJNXWOTSA-N 642914 (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-10-(2,5,8,11-tetraoxatetradecanoyloxy)-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylic acid::US11858959, Compound 15-x::US20240209019, Compound noid16 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens >10000 US Patent US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=642914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=642914&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 168146473 488875757 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8 1426074 COCCOCCOCCOCCOCCOCCC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2C(=O)C=C2[C@@H]4C[C@](C)(CC[C@]4(C)CC[C@@]32C)C(=O)OCc2ccc(c(OCc3c[nH]nn3)c2)[N+]([O-])=O)[C@]1(C)C(=O)OCc1oc(=O)oc1C InChI=1S/C59H82N4O19/c1-38-46(81-53(68)80-38)37-79-52(67)59(7)47-11-15-58(6)50(56(47,4)14-12-48(59)82-49(65)13-20-72-23-24-74-27-28-76-30-29-75-26-25-73-22-21-71-8)44(64)32-41-42-33-55(3,17-16-54(42,2)18-19-57(41,58)5)51(66)78-35-39-9-10-43(63(69)70)45(31-39)77-36-40-34-60-62-61-40/h9-10,31-32,34,42,47-48,50H,11-30,33,35-37H2,1-8H3,(H,60,61,62)/t42-,47+,48-,50+,54+,55-,56-,57+,58+,59-/m0/s1 CDRIXLHCOOWUCE-XRFKNIGYSA-N 683099 2-(3-((1-PEG5K -1H-1,2,3-triazol-4-yl)methoxy)-4-nitrobenzyl) 9-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl) (2S,4aS,6aS,6bR,8aR,9S,10S,12aS,12bR,14bR)-10-((2,5,8,11-tetraoxatetradecan-14-oyl)oxy)-2,4a,6a,6b,9,12a-hexamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2,9-dicarboxylate::US20240209019, Compound 605-2 11-beta-hydroxysteroid dehydrogenase type 2 Homo sapiens 126 US Patent 10.7270/Q2TF02NW US20240209019 Dragoli, D; Luehr, G; Chen, T; Lewis, J; Leadbetter, M Ardelyx http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=683099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1407&target=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=683099&enzyme=11-beta-hydroxysteroid+dehydrogenase+type+2&column=ki&startPg=0&Increment=50&submit=Search 172055970 503272500 1 MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR 11-beta-hydroxysteroid dehydrogenase type 2 DHI2_HUMAN P80365 A7LB28 C5HTY7 Q13194 Q6P2G9 Q8N439 Q96QN8 Q99887 Q9UC50 Q9UC51 Q9UCW5 Q9UCW6 Q9UCW7 Q9UCW8