BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1214478 FC(F)(F)c1cccc(c1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C22H18ClF3N2OS/c23-15-4-5-18-17(7-15)28-20(30-18)13-8-21(9-13)10-16(11-21)27-19(29)12-2-1-3-14(6-12)22(24,25)26/h1-7,13,16H,8-11H2,(H,27,29) NFXRTAXVGYCHNA-UHFFFAOYSA-N 576319 WO2022112188, Example 1 External core antigen 4530 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576319&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178039 474498527 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214480 NS(=O)(=O)c1cccc(c1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C21H20ClN3O3S2/c22-14-4-5-18-17(7-14)25-20(29-18)13-8-21(9-13)10-15(11-21)24-19(26)12-2-1-3-16(6-12)30(23,27)28/h1-7,13,15H,8-11H2,(H,24,26)(H2,23,27,28) AWHXTUILFNEOBM-UHFFFAOYSA-N 576320 WO2022112188, Example 2 External core antigen 3330 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576320&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178040 474498528 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214482 CP(C)(=O)c1cccc(c1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C23H24ClN2O2PS/c1-29(2,28)18-5-3-4-14(8-18)21(27)25-17-12-23(13-17)10-15(11-23)22-26-19-9-16(24)6-7-20(19)30-22/h3-9,15,17H,10-13H2,1-2H3,(H,25,27) AMICUZGMFJDVKP-UHFFFAOYSA-N 576321 WO2022112188, Example 3 External core antigen 4390 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576321&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178041 474498529 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214484 FC(F)(F)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C21H17ClF3N3OS/c22-13-1-2-16-15(6-13)28-19(30-16)12-7-20(8-12)9-14(10-20)27-18(29)11-3-4-26-17(5-11)21(23,24)25/h1-6,12,14H,7-10H2,(H,27,29) VHKVYGUKNGKPOX-UHFFFAOYSA-N 576322 WO2022112188, Example 4 External core antigen 4340 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576322&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178042 474498530 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214486 Clc1ccc2sc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccnc(c2)C#N)C1 InChI=1S/C21H17ClN4OS/c22-14-1-2-18-17(6-14)26-20(28-18)13-7-21(8-13)9-16(10-21)25-19(27)12-3-4-24-15(5-12)11-23/h1-6,13,16H,7-10H2,(H,25,27) RXVGQEUXBRXHCR-UHFFFAOYSA-N 576323 WO2022112188, Example 5 External core antigen 2920 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576323&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178043 474498531 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214488 Cc1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C21H20ClN3OS/c1-12-6-13(4-5-23-12)19(26)24-16-10-21(11-16)8-14(9-21)20-25-17-7-15(22)2-3-18(17)27-20/h2-7,14,16H,8-11H2,1H3,(H,24,26) MFNXPLMZUUNYDR-UHFFFAOYSA-N 576324 WO2022112188, Example 6 External core antigen 3300 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576324&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178044 474498532 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214490 CS(=O)(=O)Cc1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C22H22ClN3O3S2/c1-31(28,29)12-16-6-13(4-5-24-16)20(27)25-17-10-22(11-17)8-14(9-22)21-26-18-7-15(23)2-3-19(18)30-21/h2-7,14,17H,8-12H2,1H3,(H,25,27) YJZFPKJEERRMIC-UHFFFAOYSA-N 576325 WO2022112188, Example 7 External core antigen 3090 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576325&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178045 474498533 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214492 CC(C)(c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1)S(C)(=O)=O InChI=1S/C24H26ClN3O3S2/c1-23(2,33(3,30)31)20-8-14(6-7-26-20)21(29)27-17-12-24(13-17)10-15(11-24)22-28-18-9-16(25)4-5-19(18)32-22/h4-9,15,17H,10-13H2,1-3H3,(H,27,29) MMIAFDSVFPMXJK-UHFFFAOYSA-N 576326 WO2022112188, Example 8 External core antigen 1230 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576326&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178046 474498534 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214494 CCS(=O)(=O)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C22H22ClN3O3S2/c1-2-31(28,29)19-7-13(5-6-24-19)20(27)25-16-11-22(12-16)9-14(10-22)21-26-17-8-15(23)3-4-18(17)30-21/h3-8,14,16H,2,9-12H2,1H3,(H,25,27) LQHPBNQQLJQZGE-UHFFFAOYSA-N 576327 WO2022112188, Example 9 External core antigen 1210 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576327&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178047 474498535 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214496 NC(=O)Nc1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C21H20ClN5O2S/c22-13-1-2-16-15(6-13)26-19(30-16)12-7-21(8-12)9-14(10-21)25-18(28)11-3-4-24-17(5-11)27-20(23)29/h1-6,12,14H,7-10H2,(H,25,28)(H3,23,24,27,29) WWMYNYLKSUCBBK-UHFFFAOYSA-N 576328 WO2022112188, Example 10 External core antigen 8430 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576328&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178048 474498536 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214498 NC(=O)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C21H19ClN4O2S/c22-13-1-2-17-15(6-13)26-20(29-17)12-7-21(8-12)9-14(10-21)25-19(28)11-3-4-24-16(5-11)18(23)27/h1-6,12,14H,7-10H2,(H2,23,27)(H,25,28) MDIAVRGBXLPEKX-UHFFFAOYSA-N 576329 WO2022112188, Example 11 External core antigen 6810 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576329&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178049 474498537 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214500 NC(=O)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc3OCOc3cc2s1 InChI=1S/C22H20N4O4S/c23-19(27)15-3-11(1-2-24-15)20(28)25-13-8-22(9-13)6-12(7-22)21-26-14-4-16-17(30-10-29-16)5-18(14)31-21/h1-5,12-13H,6-10H2,(H2,23,27)(H,25,28) DAECJDWQFVCOTG-UHFFFAOYSA-N 576330 WO2022112188, Example 12 External core antigen 6530 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576330&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378988 474498538 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214502 Clc1ccc2sc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccc(o2)S(=O)(=O)C2CC2)C1 InChI=1S/C22H21ClN2O4S2/c23-13-1-5-18-16(7-13)25-21(30-18)12-8-22(9-12)10-14(11-22)24-20(26)17-4-6-19(29-17)31(27,28)15-2-3-15/h1,4-7,12,14-15H,2-3,8-11H2,(H,24,26) SCGZKCNTMSCGMH-UHFFFAOYSA-N 576331 WO2022112188, Example 13 External core antigen 360 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576331&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178050 474498539 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214504 FC(F)(F)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C20H16ClF3N2O2S/c21-11-1-3-15-13(5-11)26-18(29-15)10-6-19(7-10)8-12(9-19)25-17(27)14-2-4-16(28-14)20(22,23)24/h1-5,10,12H,6-9H2,(H,25,27) QUNFHVNCHFFGGK-UHFFFAOYSA-N 576332 WO2022112188, Example 14 External core antigen 2520 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576332&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178051 474498540 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214506 FC(F)(F)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2ccc(Cl)cc2s1 InChI=1S/C20H16ClF3N2O2S/c21-11-1-2-13-15(5-11)29-18(26-13)10-6-19(7-10)8-12(9-19)25-17(27)14-3-4-16(28-14)20(22,23)24/h1-5,10,12H,6-9H2,(H,25,27) JMZJNPJCDAUPBY-UHFFFAOYSA-N 576333 WO2022112188, Example 15 External core antigen 2070 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576333&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178052 474498541 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214508 CC(c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1)S(C)(=O)=O InChI=1S/C22H23ClN2O4S2/c1-12(31(2,27)28)17-4-5-18(29-17)20(26)24-15-10-22(11-15)8-13(9-22)21-25-16-7-14(23)3-6-19(16)30-21/h3-7,12-13,15H,8-11H2,1-2H3,(H,24,26) RXCVFPOYFBWUBZ-UHFFFAOYSA-N 576334 WO2022112188, Example 16 External core antigen 1920 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576334&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178053 474498542 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214510 CC(C)(c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1)S(C)(=O)=O InChI=1S/C23H25ClN2O4S2/c1-22(2,32(3,28)29)19-7-5-17(30-19)20(27)25-15-11-23(12-15)9-13(10-23)21-26-16-8-14(24)4-6-18(16)31-21/h4-8,13,15H,9-12H2,1-3H3,(H,25,27) DOGJLOFKYIXJJN-UHFFFAOYSA-N 576335 WO2022112188, Example 17 External core antigen 1600 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576335&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178054 474498543 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214512 OC(c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1)C(F)(F)F InChI=1S/C21H18ClF3N2O3S/c22-11-1-4-16-13(5-11)27-19(31-16)10-6-20(7-10)8-12(9-20)26-18(29)15-3-2-14(30-15)17(28)21(23,24)25/h1-5,10,12,17,28H,6-9H2,(H,26,29) XAESTIGBHQLGAX-UHFFFAOYSA-N 576336 WO2022112188, Example 18 External core antigen 4590 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576336&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178055 474498544 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214526 CS(=O)(=O)c1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H15ClN2O5S/c1-27(23,24)14-5-4-13(25-14)15(22)21-18-7-17(8-18,9-18)16-20-11-6-10(19)2-3-12(11)26-16/h2-6H,7-9H2,1H3,(H,21,22) VALPDIWUWVCNES-UHFFFAOYSA-N 576343 WO2022112205, Example 1::WO2022112205, Example 9 External core antigen 1772 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576343&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379011 474498551 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214528 CS(=O)c1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H15ClN2O4S/c1-26(23)14-5-4-13(24-14)15(22)21-18-7-17(8-18,9-18)16-20-11-6-10(19)2-3-12(11)25-16/h2-6H,7-9H2,1H3,(H,21,22) PFISAFMXTBWPNT-UHFFFAOYSA-N 576344 WO2022112205, Example 2 External core antigen 2139 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576344&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379057 474498552 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214530 C[S@](=O)c1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H15ClN2O4S/c1-26(23)14-5-4-13(24-14)15(22)21-18-7-17(8-18,9-18)16-20-11-6-10(19)2-3-12(11)25-16/h2-6H,7-9H2,1H3,(H,21,22)/t17?,18?,26-/m0/s1 PFISAFMXTBWPNT-WLYVOJLOSA-N 576345 WO2022112205, Example 2-a External core antigen 1192 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576345&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379050 474498553 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214532 C[S@@](=O)c1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H15ClN2O4S/c1-26(23)14-5-4-13(24-14)15(22)21-18-7-17(8-18,9-18)16-20-11-6-10(19)2-3-12(11)25-16/h2-6H,7-9H2,1H3,(H,21,22)/t17?,18?,26-/m1/s1 PFISAFMXTBWPNT-ZZHSESOFSA-N 576346 WO2022112205, Example 2-b External core antigen 1892 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576346&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379010 474498554 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214534 CSc1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H15ClN2O3S/c1-25-14-5-4-13(23-14)15(22)21-18-7-17(8-18,9-18)16-20-11-6-10(19)2-3-12(11)24-16/h2-6H,7-9H2,1H3,(H,21,22) LRIVSEOMYRVXOM-UHFFFAOYSA-N 576347 WO2022112205, Example 3 External core antigen 3825 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576347&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379023 474498555 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214536 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(o1)S(=O)C1CC1 InChI=1S/C20H17ClN2O4S/c21-11-1-4-14-13(7-11)22-18(27-14)19-8-20(9-19,10-19)23-17(24)15-5-6-16(26-15)28(25)12-2-3-12/h1,4-7,12H,2-3,8-10H2,(H,23,24) GBMDQFBNIJTVNQ-UHFFFAOYSA-N 576348 WO2022112205, Example 4 External core antigen 1321 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576348&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379060 474498556 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214538 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(o1)S(=O)(=O)C1CC1 InChI=1S/C20H17ClN2O5S/c21-11-1-4-14-13(7-11)22-18(28-14)19-8-20(9-19,10-19)23-17(24)15-5-6-16(27-15)29(25,26)12-2-3-12/h1,4-7,12H,2-3,8-10H2,(H,23,24) VQTCKJULAHCFLR-UHFFFAOYSA-N 576349 WO2022112205, Example 5 External core antigen 750 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576349&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379086 474498557 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214540 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(o1)S(=O)CC1CC1 InChI=1S/C21H19ClN2O4S/c22-13-3-4-15-14(7-13)23-19(28-15)20-9-21(10-20,11-20)24-18(25)16-5-6-17(27-16)29(26)8-12-1-2-12/h3-7,12H,1-2,8-11H2,(H,24,25) VOZFRJZOOJJIHE-UHFFFAOYSA-N 576350 WO2022112205, Example 6 External core antigen 1370 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576350&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379052 474498558 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214364 CCC(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C17H15N3O2/c1-2-15(21)18-14-10-8-13(9-11-14)17-20-19-16(22-17)12-6-4-3-5-7-12/h3-11H,2H2,1H3,(H,18,21) GHVKGIMUPQSPQC-UHFFFAOYSA-N 576263 WO2022112139, Example 1 External core antigen 4850 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576263&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 661234 474498471 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214366 CCCC(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C18H17N3O2/c1-2-6-16(22)19-15-11-9-14(10-12-15)18-21-20-17(23-18)13-7-4-3-5-8-13/h3-5,7-12H,2,6H2,1H3,(H,19,22) GMJMMEIADUNIAV-UHFFFAOYSA-N 576264 WO2022112139, Example 2 External core antigen 43100 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576264&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 825383 474498472 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214368 CCCCC(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C19H19N3O2/c1-2-3-9-17(23)20-16-12-10-15(11-13-16)19-22-21-18(24-19)14-7-5-4-6-8-14/h4-8,10-13H,2-3,9H2,1H3,(H,20,23) BLWXKDKXLRBXBC-UHFFFAOYSA-N 576265 WO2022112139, Example 3 External core antigen 3010 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576265&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378778 474498473 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214370 CC(C)CC(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C19H19N3O2/c1-13(2)12-17(23)20-16-10-8-15(9-11-16)19-22-21-18(24-19)14-6-4-3-5-7-14/h3-11,13H,12H2,1-2H3,(H,20,23) QVOWQWLTPZCACJ-UHFFFAOYSA-N 576266 WO2022112139, Example 4 External core antigen 3430 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576266&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 930672 474498474 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214372 COCCC(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C18H17N3O3/c1-23-12-11-16(22)19-15-9-7-14(8-10-15)18-21-20-17(24-18)13-5-3-2-4-6-13/h2-10H,11-12H2,1H3,(H,19,22) FNFZHWADRNEPFC-UHFFFAOYSA-N 576267 WO2022112139, Example 5 External core antigen 690 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576267&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378775 474498475 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214374 CC(C)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C18H17N3O2/c1-12(2)16(22)19-15-10-8-14(9-11-15)18-21-20-17(23-18)13-6-4-3-5-7-13/h3-12H,1-2H3,(H,19,22) ZZWYYGRPMKRHSX-UHFFFAOYSA-N 576268 WO2022112139, Example 6 External core antigen 2200 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576268&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 880165 474498476 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214376 O=C(Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1)C1CCCC1 InChI=1S/C20H19N3O2/c24-18(14-6-4-5-7-14)21-17-12-10-16(11-13-17)20-23-22-19(25-20)15-8-2-1-3-9-15/h1-3,8-14H,4-7H2,(H,21,24) YETWTEDKONXHTI-UHFFFAOYSA-N 576269 WO2022112139, Example 7 External core antigen 770 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576269&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 2995698 474498477 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214378 Fc1ccccc1C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C21H14FN3O2/c22-18-9-5-4-8-17(18)19(26)23-16-12-10-15(11-13-16)21-25-24-20(27-21)14-6-2-1-3-7-14/h1-13H,(H,23,26) CNDMZQGCUMVNRE-UHFFFAOYSA-N 576270 WO2022112139, Example 8 External core antigen 5060 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576270&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 24014727 474498478 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214380 Clc1ccccc1C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C21H14ClN3O2/c22-18-9-5-4-8-17(18)19(26)23-16-12-10-15(11-13-16)21-25-24-20(27-21)14-6-2-1-3-7-14/h1-13H,(H,23,26) WBYRHHSGTGEDGI-UHFFFAOYSA-N 50352939 CHEMBL1824913::WO2022112139, Example 9 External core antigen 1690 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50352939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50352939&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 1300425 136359625 CHEMBL1824913 ZINC01124174 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214382 Cc1cc(F)cc(c1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C22H16FN3O2/c1-14-11-17(13-18(23)12-14)20(27)24-19-9-7-16(8-10-19)22-26-25-21(28-22)15-5-3-2-4-6-15/h2-13H,1H3,(H,24,27) WILQAPYKCACUGH-UHFFFAOYSA-N 576272 WO2022112139, Example 10 External core antigen 2170 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576272&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378776 474498480 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214384 Cc1cc(Cl)cc(c1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C22H16ClN3O2/c1-14-11-17(13-18(23)12-14)20(27)24-19-9-7-16(8-10-19)22-26-25-21(28-22)15-5-3-2-4-6-15/h2-13H,1H3,(H,24,27) ZZSAHBJCMXNSAD-UHFFFAOYSA-N 576273 WO2022112139, Example 11 External core antigen 12650 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576273&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378768 474498481 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214386 Fc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C21H14FN3O2/c22-17-10-6-14(7-11-17)19(26)23-18-12-8-16(9-13-18)21-25-24-20(27-21)15-4-2-1-3-5-15/h1-13H,(H,23,26) JFMGZQNKGOLWAM-UHFFFAOYSA-N 576274 WO2022112139, Example 12 External core antigen 6330 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576274&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 4328418 474498482 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214388 Clc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C21H14ClN3O2/c22-17-10-6-14(7-11-17)19(26)23-18-12-8-16(9-13-18)21-25-24-20(27-21)15-4-2-1-3-5-15/h1-13H,(H,23,26) RURBVQFLRGZYHB-UHFFFAOYSA-N 576275 WO2022112139, Example 13 External core antigen 4430 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576275&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 1367813 474498483 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214390 FC(F)(F)Oc1ccccc1C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C22H14F3N3O3/c23-22(24,25)31-18-9-5-4-8-17(18)19(29)26-16-12-10-15(11-13-16)21-28-27-20(30-21)14-6-2-1-3-7-14/h1-13H,(H,26,29) MZMPCVUIFGMESP-UHFFFAOYSA-N 576276 WO2022112139, Example 14 External core antigen 2880 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576276&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378773 474498484 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214392 FC(F)Oc1ccccc1C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C22H15F2N3O3/c23-22(24)29-18-9-5-4-8-17(18)19(28)25-16-12-10-15(11-13-16)21-27-26-20(30-21)14-6-2-1-3-7-14/h1-13,22H,(H,25,28) IYVAEHHOGLAKDH-UHFFFAOYSA-N 576277 WO2022112139, Example 15 External core antigen 1940 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576277&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378764 474498485 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214394 FC(F)(F)Oc1cccc(c1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C22H14F3N3O3/c23-22(24,25)31-18-8-4-7-16(13-18)19(29)26-17-11-9-15(10-12-17)21-28-27-20(30-21)14-5-2-1-3-6-14/h1-13H,(H,26,29) CZEYACGFHFCVKB-UHFFFAOYSA-N 576278 WO2022112139, Example 16 External core antigen 2910 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576278&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378770 474498486 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214396 FC(F)Oc1cccc(c1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C22H15F2N3O3/c23-22(24)29-18-8-4-7-16(13-18)19(28)25-17-11-9-15(10-12-17)21-27-26-20(30-21)14-5-2-1-3-6-14/h1-13,22H,(H,25,28) KRHWZNFWFOLJMB-UHFFFAOYSA-N 576279 WO2022112139, Example 17 External core antigen 2790 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576279&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378779 474498487 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214398 O=C(Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1)c1ccc(cc1)C#N InChI=1S/C22H14N4O2/c23-14-15-6-8-16(9-7-15)20(27)24-19-12-10-18(11-13-19)22-26-25-21(28-22)17-4-2-1-3-5-17/h1-13H,(H,24,27) OPYWHQUNKVNQIR-UHFFFAOYSA-N 576280 WO2022112139, Example 18 External core antigen 2260 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576280&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378761 474498488 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214400 O=C(Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1)c1ccncc1 InChI=1S/C20H14N4O2/c25-18(14-10-12-21-13-11-14)22-17-8-6-16(7-9-17)20-24-23-19(26-20)15-4-2-1-3-5-15/h1-13H,(H,22,25) GLCNQRIBBQRYEN-UHFFFAOYSA-N 576281 WO2022112139, Example 19 External core antigen 2800 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576281&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378774 474498489 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214402 Clc1cc(ccn1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C20H13ClN4O2/c21-17-12-15(10-11-22-17)18(26)23-16-8-6-14(7-9-16)20-25-24-19(27-20)13-4-2-1-3-5-13/h1-12H,(H,23,26) IZLSURJBWMZUJA-UHFFFAOYSA-N 576282 WO2022112139, Example 20 External core antigen 2560 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576282&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378762 474498490 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214404 COc1cc(ccn1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C21H16N4O3/c1-27-18-13-16(11-12-22-18)19(26)23-17-9-7-15(8-10-17)21-25-24-20(28-21)14-5-3-2-4-6-14/h2-13H,1H3,(H,23,26) AAHYYWUYTNVESS-UHFFFAOYSA-N 576283 WO2022112139, Example 21 External core antigen 1910 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576283&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378766 474498491 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214406 Clc1cccc(n1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C20H13ClN4O2/c21-17-8-4-7-16(23-17)18(26)22-15-11-9-14(10-12-15)20-25-24-19(27-20)13-5-2-1-3-6-13/h1-12H,(H,22,26) WBSOVHPFAQCADJ-UHFFFAOYSA-N 576284 WO2022112139, Example 22 External core antigen 1590 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576284&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378782 474498492 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214408 Clc1ccc(nc1)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C20H13ClN4O2/c21-15-8-11-17(22-12-15)18(26)23-16-9-6-14(7-10-16)20-25-24-19(27-20)13-4-2-1-3-5-13/h1-12H,(H,23,26) YHGDZJDOPBWDSA-UHFFFAOYSA-N 576285 WO2022112139, Example 23 External core antigen 2120 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576285&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378777 474498493 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214410 O=C(Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1)c1ccnnc1 InChI=1S/C19H13N5O2/c25-17(15-10-11-20-21-12-15)22-16-8-6-14(7-9-16)19-24-23-18(26-19)13-4-2-1-3-5-13/h1-12H,(H,22,25) VBAZPINJBSMBOM-UHFFFAOYSA-N 576286 WO2022112139, Example 24 External core antigen 1600 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576286&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378780 474498494 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214412 O=C(Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1)c1cccnn1 InChI=1S/C19H13N5O2/c25-17(16-7-4-12-20-22-16)21-15-10-8-14(9-11-15)19-24-23-18(26-19)13-5-2-1-3-6-13/h1-12H,(H,21,25) ZVALCPCPSOOBRG-UHFFFAOYSA-N 576287 WO2022112139, Example 25 External core antigen 1270 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576287&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378767 474498495 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214414 O=C(Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1)c1ncco1 InChI=1S/C18H12N4O3/c23-15(18-19-10-11-24-18)20-14-8-6-13(7-9-14)17-22-21-16(25-17)12-4-2-1-3-5-12/h1-11H,(H,20,23) ODIIHXDHLFVPSU-UHFFFAOYSA-N 576288 WO2022112139, Example 26 External core antigen 1420 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576288&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378772 474498496 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214416 O=C(Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1)c1nccs1 InChI=1S/C18H12N4O2S/c23-15(18-19-10-11-25-18)20-14-8-6-13(7-9-14)17-22-21-16(24-17)12-4-2-1-3-5-12/h1-11H,(H,20,23) XGJKDIOBQJKHRJ-UHFFFAOYSA-N 576289 WO2022112139, Example 27 External core antigen 1710 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576289&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378769 474498497 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214418 CC(C)(C)C(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C19H19N3O2/c1-19(2,3)18(23)20-15-11-9-14(10-12-15)17-22-21-16(24-17)13-7-5-4-6-8-13/h4-12H,1-3H3,(H,20,23) UDYQZDWAVMDJDK-UHFFFAOYSA-N 576290 WO2022112139, Example 28 External core antigen 4230 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576290&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 132846522 474498498 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214420 CC(C)(C)CC(=O)Nc1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C20H21N3O2/c1-20(2,3)13-17(24)21-16-11-9-15(10-12-16)19-23-22-18(25-19)14-7-5-4-6-8-14/h4-12H,13H2,1-3H3,(H,21,24) YCKXMCJOLIECGI-UHFFFAOYSA-N 576291 WO2022112139, Example 29 External core antigen 9570 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576291&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378765 474498499 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214422 Cc1cc(ccc1N)-c1nnc(o1)-c1ccccc1 InChI=1S/C15H13N3O/c1-10-9-12(7-8-13(10)16)15-18-17-14(19-15)11-5-3-2-4-6-11/h2-9H,16H2,1H3 ZOJCZFUBQRSJDL-UHFFFAOYSA-N 576292 WO2022112139, Example 30 External core antigen 3210 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576292&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 55034250 474498500 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214424 COc1cc(ccc1N)-c1nnc(o1)-c1ccccc1 InChI=1S/C15H13N3O2/c1-19-13-9-11(7-8-12(13)16)15-18-17-14(20-15)10-5-3-2-4-6-10/h2-9H,16H2,1H3 LFRSONJOPYJHMX-UHFFFAOYSA-N 576293 WO2022112139, Example 31 External core antigen 4170 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576293&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 104783443 474498501 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214426 Nc1ccc(cc1F)-c1nnc(o1)-c1ccccc1 InChI=1S/C14H10FN3O/c15-11-8-10(6-7-12(11)16)14-18-17-13(19-14)9-4-2-1-3-5-9/h1-8H,16H2 NIBVWVSAEJIAJR-UHFFFAOYSA-N 576294 WO2022112139, Example 32 External core antigen 2810 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576294&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378763 474498502 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214428 CN(C)c1ccc(cc1)-c1nnc(o1)-c1ccccc1 InChI=1S/C16H15N3O/c1-19(2)14-10-8-13(9-11-14)16-18-17-15(20-16)12-6-4-3-5-7-12/h3-11H,1-2H3 JNDYNKXUHHOEKB-UHFFFAOYSA-N 576295 WO2022112139, Example 33 External core antigen 91650 WIPO 10.7270/Q2D221WV aid1806893 WO2022112139 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576295&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 671915 474498503 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214514 Nc1nc(cs1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C18H17ClN4OS2/c19-10-1-2-14-12(3-10)22-16(26-14)9-4-18(5-9)6-11(7-18)21-15(24)13-8-25-17(20)23-13/h1-3,8-9,11H,4-7H2,(H2,20,23)(H,21,24) YZIKGLMJLNQWNL-UHFFFAOYSA-N 576337 WO2022112188, Example 19 External core antigen 6830 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576337&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178056 474498545 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214516 Clc1ccc2sc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccc(o2)S(=O)(=O)N2CCC2)C1 InChI=1S/C22H22ClN3O4S2/c23-14-2-4-18-16(8-14)25-21(31-18)13-9-22(10-13)11-15(12-22)24-20(27)17-3-5-19(30-17)32(28,29)26-6-1-7-26/h2-5,8,13,15H,1,6-7,9-12H2,(H,24,27) HFEGMXVMAPYZPF-UHFFFAOYSA-N 576338 WO2022112188, Example 20 External core antigen 4060 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576338&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178057 474498546 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214518 FC1(F)CN(C1)S(=O)(=O)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C22H20ClF2N3O4S2/c23-13-1-3-17-15(5-13)27-20(33-17)12-6-21(7-12)8-14(9-21)26-19(29)16-2-4-18(32-16)34(30,31)28-10-22(24,25)11-28/h1-5,12,14H,6-11H2,(H,26,29) LIIBNATUBDNJEM-UHFFFAOYSA-N 576339 WO2022112188, Example 21 External core antigen 1140 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576339&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178058 474498547 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214520 Clc1ccc2sc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccc(o2)S(=O)(=O)NC2CCC2)C1 InChI=1S/C23H24ClN3O4S2/c24-14-4-6-19-17(8-14)26-22(32-19)13-9-23(10-13)11-16(12-23)25-21(28)18-5-7-20(31-18)33(29,30)27-15-2-1-3-15/h4-8,13,15-16,27H,1-3,9-12H2,(H,25,28) ZRZGUCARKWZLBN-UHFFFAOYSA-N 576340 WO2022112188, Example 22 External core antigen 1000 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576340&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178059 474498548 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214522 FC1(F)CC(C1)NS(=O)(=O)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C23H22ClF2N3O4S2/c24-13-1-3-18-16(5-13)28-21(34-18)12-6-22(7-12)8-14(9-22)27-20(30)17-2-4-19(33-17)35(31,32)29-15-10-23(25,26)11-15/h1-5,12,14-15,29H,6-11H2,(H,27,30) UFMNSRZKKGIWHB-UHFFFAOYSA-N 576341 WO2022112188, Example 23 External core antigen 850 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576341&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178060 474498549 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214524 FC(F)(F)C1CC(C1)NS(=O)(=O)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2s1 InChI=1S/C24H23ClF3N3O4S2/c25-14-1-3-19-17(7-14)30-22(36-19)12-8-23(9-12)10-16(11-23)29-21(32)18-2-4-20(35-18)37(33,34)31-15-5-13(6-15)24(26,27)28/h1-4,7,12-13,15-16,31H,5-6,8-11H2,(H,29,32) FIWATOUMZCFJQQ-UHFFFAOYSA-N 576342 WO2022112188, Example 24 External core antigen 1040 WIPO 10.7270/Q24M97T4 aid1806895 WO2022112188 Xianfeng, L; Jianping, W; Hongying, Y; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576342&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178061 474498550 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214542 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(o1)S(=O)(=O)CC1CC1 InChI=1S/C21H19ClN2O5S/c22-13-3-4-15-14(7-13)23-19(29-15)20-9-21(10-20,11-20)24-18(25)16-5-6-17(28-16)30(26,27)8-12-1-2-12/h3-7,12H,1-2,8-11H2,(H,24,25) NNHGPFIELIJRJO-UHFFFAOYSA-N 576369 WO2022112205, Example 7 External core antigen 1212 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576369&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379026 474498575 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214544 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(Br)o1 InChI=1S/C17H12BrClN2O3/c18-13-4-3-12(23-13)14(22)21-17-6-16(7-17,8-17)15-20-10-5-9(19)1-2-11(10)24-15/h1-5H,6-8H2,(H,21,22) QDBWAIREZLRMRB-UHFFFAOYSA-N 576351 WO2022112205, Example 8 External core antigen 14803 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576351&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379064 474498559 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214546 CS(=O)(=O)c1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H15ClN2O5S/c1-27(23,24)14-5-4-13(25-14)15(22)21-18-7-17(8-18,9-18)16-20-11-6-10(19)2-3-12(11)26-16/h2-6H,7-9H2,1H3,(H,21,22) VALPDIWUWVCNES-UHFFFAOYSA-N 576343 WO2022112205, Example 1::WO2022112205, Example 9 External core antigen 5367 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576343&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379011 474498551 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214548 NS(=O)(=O)c1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C17H14ClN3O5S/c18-9-1-2-11-10(5-9)20-15(26-11)16-6-17(7-16,8-16)21-14(22)12-3-4-13(25-12)27(19,23)24/h1-5H,6-8H2,(H,21,22)(H2,19,23,24) MKZPBYIBVQBLGP-UHFFFAOYSA-N 576353 WO2022112205, Example 10 External core antigen 2668 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576353&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379024 474498560 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214550 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(o1)S(=N)(=O)C1CC1 InChI=1S/C20H18ClN3O4S/c21-11-1-4-14-13(7-11)23-18(28-14)19-8-20(9-19,10-19)24-17(25)15-5-6-16(27-15)29(22,26)12-2-3-12/h1,4-7,12,22H,2-3,8-10H2,(H,24,25) MWERLTVMUGJDJT-UHFFFAOYSA-N 576354 WO2022112205, Example 11 External core antigen 594 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576354&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379074 474498561 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214552 CS(=N)(=O)c1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H16ClN3O4S/c1-27(20,24)14-5-4-13(25-14)15(23)22-18-7-17(8-18,9-18)16-21-11-6-10(19)2-3-12(11)26-16/h2-6,20H,7-9H2,1H3,(H,22,23) WRIHOHKMUOFPPP-UHFFFAOYSA-N 576355 WO2022112205, Example 12 External core antigen 891 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576355&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379062 474498562 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214554 C[S@@](=N)(=O)c1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H16ClN3O4S/c1-27(20,24)14-5-4-13(25-14)15(23)22-18-7-17(8-18,9-18)16-21-11-6-10(19)2-3-12(11)26-16/h2-6,20H,7-9H2,1H3,(H,22,23)/t17?,18?,27-/m1/s1 WRIHOHKMUOFPPP-DIAWHCHDSA-N 576356 WO2022112205, Example 12-a External core antigen 1304 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576356&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379065 474498563 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214556 C[S@](=N)(=O)c1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H16ClN3O4S/c1-27(20,24)14-5-4-13(25-14)15(23)22-18-7-17(8-18,9-18)16-21-11-6-10(19)2-3-12(11)26-16/h2-6,20H,7-9H2,1H3,(H,22,23)/t17?,18?,27-/m0/s1 WRIHOHKMUOFPPP-ZQDGVCNQSA-N 576357 WO2022112205, Example 12-b External core antigen 1013 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576357&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379076 474498564 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214558 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(o1)S(=N)(=O)CC1CC1 InChI=1S/C21H20ClN3O4S/c22-13-3-4-15-14(7-13)24-19(29-15)20-9-21(10-20,11-20)25-18(26)16-5-6-17(28-16)30(23,27)8-12-1-2-12/h3-7,12,23H,1-2,8-11H2,(H,25,26) MFBHPTAYBVZFNL-UHFFFAOYSA-N 576358 WO2022112205, Example 13 External core antigen 995 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576358&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379056 474498565 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214560 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(o1)S(=O)(=O)CC1COC1 InChI=1S/C21H19ClN2O6S/c22-13-1-2-15-14(5-13)23-19(30-15)20-9-21(10-20,11-20)24-18(25)16-3-4-17(29-16)31(26,27)8-12-6-28-7-12/h1-5,12H,6-11H2,(H,24,25) RSPSUXZSCCQRTL-UHFFFAOYSA-N 576359 WO2022112205, Example 14 External core antigen 3560 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576359&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379018 474498566 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214562 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(o1)S(=N)(=O)CC1COC1 InChI=1S/C21H20ClN3O5S/c22-13-1-2-15-14(5-13)24-19(30-15)20-9-21(10-20,11-20)25-18(26)16-3-4-17(29-16)31(23,27)8-12-6-28-7-12/h1-5,12,23H,6-11H2,(H,25,26) JEBKXSKKYQCQHS-UHFFFAOYSA-N 576360 WO2022112205, Example 15 External core antigen 3305 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576360&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379017 474498567 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214564 CS(=O)(=O)Cc1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C19H17ClN2O5S/c1-28(24,25)7-12-3-5-15(26-12)16(23)22-19-8-18(9-19,10-19)17-21-13-6-11(20)2-4-14(13)27-17/h2-6H,7-10H2,1H3,(H,22,23) ZLTOVNRPBCTUQJ-UHFFFAOYSA-N 576361 WO2022112205, Example 16 External core antigen 575 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576361&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379068 474498568 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214566 CS(=N)(=O)Cc1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C19H18ClN3O4S/c1-28(21,25)7-12-3-5-15(26-12)16(24)23-19-8-18(9-19,10-19)17-22-13-6-11(20)2-4-14(13)27-17/h2-6,21H,7-10H2,1H3,(H,23,24) MHUPVGLJDKRGGT-UHFFFAOYSA-N 576362 WO2022112205, Example 17 External core antigen 2192 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576362&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379014 474498569 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214568 NS(=O)(=O)Cc1ccc(o1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C18H16ClN3O5S/c19-10-1-3-13-12(5-10)21-16(27-13)17-7-18(8-17,9-17)22-15(23)14-4-2-11(26-14)6-28(20,24)25/h1-5H,6-9H2,(H,22,23)(H2,20,24,25) OMSLAZFRPDWRLZ-UHFFFAOYSA-N 576363 WO2022112205, Example 18 External core antigen 3695 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576363&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379071 474498570 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214570 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1cccc(Br)c1 InChI=1S/C19H14BrClN2O2/c20-12-3-1-2-11(6-12)16(24)23-19-8-18(9-19,10-19)17-22-14-7-13(21)4-5-15(14)25-17/h1-7H,8-10H2,(H,23,24) WMDKFIBOKBYHBY-UHFFFAOYSA-N 576364 WO2022112205, Example 19 External core antigen 3231 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576364&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379035 474498571 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214572 Clc1ccc2oc(nc2c1)C12CC(C1)(C2)NC(=O)c1ccc(Br)cc1 InChI=1S/C19H14BrClN2O2/c20-12-3-1-11(2-4-12)16(24)23-19-8-18(9-19,10-19)17-22-14-7-13(21)5-6-15(14)25-17/h1-7H,8-10H2,(H,23,24) LDQOAXXQKHKGAX-UHFFFAOYSA-N 576365 WO2022112205, Example 20 External core antigen 7206 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576365&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379091 474498572 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214574 CSc1cccc(c1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H17ClN2O2S/c1-26-14-4-2-3-12(7-14)17(24)23-20-9-19(10-20,11-20)18-22-15-8-13(21)5-6-16(15)25-18/h2-8H,9-11H2,1H3,(H,23,24) QISAJBADVONOBL-UHFFFAOYSA-N 576366 WO2022112205, Example 21 External core antigen 1871 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576366&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379034 474498573 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214576 CS(=O)(=O)c1cccc(c1)C(=O)NC12CC(C1)(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H17ClN2O4S/c1-28(25,26)14-4-2-3-12(7-14)17(24)23-20-9-19(10-20,11-20)18-22-15-8-13(21)5-6-16(15)27-18/h2-8H,9-11H2,1H3,(H,23,24) FVYXNRMRDKRKRO-UHFFFAOYSA-N 576367 WO2022112205, Example 22 External core antigen 2334 WIPO 10.7270/Q20V8H2C aid1806896 WO2022112205 Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576367&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379012 474498574 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214578 FC(F)(F)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H16ClF3N2O3/c21-11-1-2-14-13(5-11)26-18(29-14)10-6-19(7-10)8-12(9-19)25-17(27)15-3-4-16(28-15)20(22,23)24/h1-5,10,12H,6-9H2,(H,25,27) CBPJFNVRDKJMNZ-UHFFFAOYSA-N 576370 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(trifluoromethyl)furan-2-carboxamide::WO2022112207, Example 1 External core antigen 2291 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576370&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379241 474498576 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214580 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccc(o2)C#N)C1 InChI=1S/C20H16ClN3O3/c21-12-1-3-16-15(5-12)24-19(27-16)11-6-20(7-11)8-13(9-20)23-18(25)17-4-2-14(10-22)26-17/h1-5,11,13H,6-9H2,(H,23,25) PJBBUBZTNPWKSD-UHFFFAOYSA-N 576371 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-cyano-furan-2-carboxamide::WO2022112207, Example 2 External core antigen 4061 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576371&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379185 474498577 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214582 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccc(Br)o2)C1 InChI=1S/C19H16BrClN2O3/c20-16-4-3-15(25-16)17(24)22-12-8-19(9-12)6-10(7-19)18-23-13-5-11(21)1-2-14(13)26-18/h1-5,10,12H,6-9H2,(H,22,24) NHORZENUGNEXLO-UHFFFAOYSA-N 576372 5-bromo-N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]furan-2-carboxamide::WO2022112207, Example 3 External core antigen 7640 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576372&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379099 474498578 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214584 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2cc(Br)co2)C1 InChI=1S/C19H16BrClN2O3/c20-11-3-16(25-9-11)17(24)22-13-7-19(8-13)5-10(6-19)18-23-14-4-12(21)1-2-15(14)26-18/h1-4,9-10,13H,5-8H2,(H,22,24) PVEKRQDTCRRAKB-UHFFFAOYSA-N 576373 4-bromo-N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]furan-2-carboxamide::WO2022112207, Example 4 External core antigen 2940 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576373&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379214 474498579 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214586 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2occc2Br)C1 InChI=1S/C19H16BrClN2O3/c20-13-3-4-25-16(13)17(24)22-12-8-19(9-12)6-10(7-19)18-23-14-5-11(21)1-2-15(14)26-18/h1-5,10,12H,6-9H2,(H,22,24) ZMMIOFCCHDLZKO-UHFFFAOYSA-N 576374 3-bromo-N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]furan-2-carboxamide::WO2022112207, Example 5 External core antigen 6285 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576374&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379254 474498580 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214588 Clc1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C19H16Cl2N2O3/c20-11-1-2-14-13(5-11)23-18(26-14)10-6-19(7-10)8-12(9-19)22-17(24)15-3-4-16(21)25-15/h1-5,10,12H,6-9H2,(H,22,24) FEUAAZJDTOPGPN-UHFFFAOYSA-N 576375 5-chloro-N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]furan-2-carboxamide::WO2022112207, Example 6 External core antigen 2083 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576375&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379223 474498581 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214590 CC(C)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C22H23ClN2O3/c1-12(2)17-5-6-19(27-17)20(26)24-15-10-22(11-15)8-13(9-22)21-25-16-7-14(23)3-4-18(16)28-21/h3-7,12-13,15H,8-11H2,1-2H3,(H,24,26) SGLKSEAVENHHOE-UHFFFAOYSA-N 576376 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-isopropyl-furan-2-carboxamide::WO2022112207, Example 7 External core antigen 1337 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576376&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379231 474498582 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214592 COc1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H19ClN2O4/c1-25-17-5-4-16(26-17)18(24)22-13-9-20(10-13)7-11(8-20)19-23-14-6-12(21)2-3-15(14)27-19/h2-6,11,13H,7-10H2,1H3,(H,22,24) NWLYYMYIJSNWPW-UHFFFAOYSA-N 576377 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-methoxy-furan-2-carboxamide::WO2022112207, Example 8 External core antigen 5838 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576377&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379186 474498583 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214594 COCc1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C21H21ClN2O4/c1-26-11-15-3-5-18(27-15)19(25)23-14-9-21(10-14)7-12(8-21)20-24-16-6-13(22)2-4-17(16)28-20/h2-6,12,14H,7-11H2,1H3,(H,23,25) JDPMVIVPLBGIFH-UHFFFAOYSA-N 576378 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(methoxymethyl)furan-2-carboxamide::WO2022112207, Example 9 External core antigen 1015 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576378&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379233 474498584 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214596 OC(C1CC1)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C23H23ClN2O4/c24-14-3-4-17-16(7-14)26-22(30-17)13-8-23(9-13)10-15(11-23)25-21(28)19-6-5-18(29-19)20(27)12-1-2-12/h3-7,12-13,15,20,27H,1-2,8-11H2,(H,25,28) IPYGJUZELMQGHJ-UHFFFAOYSA-N 576379 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(cyclopropanecarbonyl)furan-2-carboxamide::WO2022112207, Example 10 External core antigen 2941 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576379&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178062 474498585 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214598 NC(O)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H20ClN3O4/c21-11-1-2-14-13(5-11)24-19(28-14)10-6-20(7-10)8-12(9-20)23-18(26)16-4-3-15(27-16)17(22)25/h1-5,10,12,17,25H,6-9,22H2,(H,23,26) FUCHGKCGVMKTBT-UHFFFAOYSA-N 576380 N2-[6-(5-Chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]furan-2,5-dicarboxamide::WO2022112207, Example 11 External core antigen 5221 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576380&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178063 474498586 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214600 FC(F)(F)c1cc([nH]n1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C19H16ClF3N4O2/c20-10-1-2-14-12(3-10)25-17(29-14)9-5-18(6-9)7-11(8-18)24-16(28)13-4-15(27-26-13)19(21,22)23/h1-4,9,11H,5-8H2,(H,24,28)(H,26,27) GEPZJGPHUDGNQU-UHFFFAOYSA-N 576381 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide::WO2022112207, Example 12 External core antigen 6855 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576381&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379256 474498587 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214602 Cn1cc(cn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C19H19ClN4O2/c1-24-10-12(9-21-24)17(25)22-14-7-19(8-14)5-11(6-19)18-23-15-4-13(20)2-3-16(15)26-18/h2-4,9-11,14H,5-8H2,1H3,(H,22,25) CXWSBUUKUPTUQY-UHFFFAOYSA-N 576382 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-1-methyl-pyrazole-4-carboxamide::WO2022112207, Example 13 External core antigen 6202 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576382&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379107 474498588 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214604 CS(=O)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H19ClN2O4S/c1-28(25)17-5-4-16(26-17)18(24)22-13-9-20(10-13)7-11(8-20)19-23-14-6-12(21)2-3-15(14)27-19/h2-6,11,13H,7-10H2,1H3,(H,22,24) BCMMDZXQLGVVGW-UHFFFAOYSA-N 576383 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-methylsulfinyl-furan-2-carboxamide::WO2022112207, Example 14 External core antigen 854 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576383&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379191 474498589 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214606 CS(=O)(=O)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H19ClN2O5S/c1-29(25,26)17-5-4-16(27-17)18(24)22-13-9-20(10-13)7-11(8-20)19-23-14-6-12(21)2-3-15(14)28-19/h2-6,11,13H,7-10H2,1H3,(H,22,24) JTKHJALJNCGAAT-UHFFFAOYSA-N 576384 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-methylsulfonyl-furan-2-carboxamide::WO2022112207, Example 15 External core antigen 1165 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576384&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379102 474498590 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214608 CS(=O)(=O)c1ccc(o1)C(=O)NC1C[C@@]2(C1)C[C@@H](C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H19ClN2O5S/c1-29(25,26)17-5-4-16(27-17)18(24)22-13-9-20(10-13)7-11(8-20)19-23-14-6-12(21)2-3-15(14)28-19/h2-6,11,13H,7-10H2,1H3,(H,22,24)/t11-,13?,20- JTKHJALJNCGAAT-MWABQWBSSA-N 576385 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-methylsulfonyl-furan-2-carboxamide::WO2022112207, Example 15-a External core antigen 3942 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576385&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379102 474498591 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214610 CS(=O)(=O)c1ccc(o1)C(=O)NC1C[C@@]2(C1)C[C@@H](C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H19ClN2O5S/c1-29(25,26)17-5-4-16(27-17)18(24)22-13-9-20(10-13)7-11(8-20)19-23-14-6-12(21)2-3-15(14)28-19/h2-6,11,13H,7-10H2,1H3,(H,22,24)/t11-,13?,20- JTKHJALJNCGAAT-MWABQWBSSA-N 576386 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-methylsulfonyl-furan-2-carboxamide::WO2022112207, Example 15-b External core antigen 694 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576386&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379102 474498592 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214612 CCS(=O)(=O)c1ccc(o1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C21H21ClN2O5S/c1-2-30(26,27)18-6-5-17(28-18)19(25)23-14-10-21(11-14)8-12(9-21)20-24-15-7-13(22)3-4-16(15)29-20/h3-7,12,14H,2,8-11H2,1H3,(H,23,25) RVQKSTIDOPNUIO-UHFFFAOYSA-N 576387 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-ethylsulfonyl-furan-2-carboxamide::WO2022112207, Example 16 External core antigen 1026 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576387&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379105 474498593 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214614 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccc(o2)S(=O)(=O)C2CC2)C1 InChI=1S/C22H21ClN2O5S/c23-13-1-4-17-16(7-13)25-21(30-17)12-8-22(9-12)10-14(11-22)24-20(26)18-5-6-19(29-18)31(27,28)15-2-3-15/h1,4-7,12,14-15H,2-3,8-11H2,(H,24,26) YYOMHFRXZWJASD-UHFFFAOYSA-N 576388 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-cyclopropylsulfonyl-furan-2-carboxamide::WO2022112207, Example 17 External core antigen 177 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576388&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379199 474498594 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214616 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccc(o2)S(=O)(=O)C2COC2)C1 InChI=1S/C22H21ClN2O6S/c23-13-1-2-17-16(5-13)25-21(31-17)12-6-22(7-12)8-14(9-22)24-20(26)18-3-4-19(30-18)32(27,28)15-10-29-11-15/h1-5,12,14-15H,6-11H2,(H,24,26) PFHJJVRJJRAKMO-UHFFFAOYSA-N 576389 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(oxetan-3-ylsulfonyl)furan-2-carboxamide::WO2022112207, Example 18 External core antigen 1812 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576389&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379217 474498595 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214618 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccc(o2)S(=O)CC2CC2)C1 InChI=1S/C23H23ClN2O4S/c24-15-3-4-18-17(7-15)26-22(30-18)14-8-23(9-14)10-16(11-23)25-21(27)19-5-6-20(29-19)31(28)12-13-1-2-13/h3-7,13-14,16H,1-2,8-12H2,(H,25,27) IGBLCXVNXCXYHT-UHFFFAOYSA-N 576390 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(cyclopropylmethylsulfinyl)furan-2-carboxamide::WO2022112207, Example 19 External core antigen 45 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576390&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379204 474498596 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214620 Clc1ccc2oc(nc2c1)[C@H]1C[C@]2(C[C@@H](C2)NC(=O)c2ccc(o2)[S@@](=O)CC2CC2)C1 InChI=1S/C23H23ClN2O4S/c24-15-3-4-18-17(7-15)26-22(30-18)14-8-23(9-14)10-16(11-23)25-21(27)19-5-6-20(29-19)31(28)12-13-1-2-13/h3-7,13-14,16H,1-2,8-12H2,(H,25,27)/t14-,16-,23-,31+/m1/s1 IGBLCXVNXCXYHT-YWHMGBGWSA-N 576391 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(cyclopropylmethylsulfinyl)furan-2-carboxamide::WO2022112207, Example 19-a External core antigen 67 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576391&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178064 474498597 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214622 Clc1ccc2oc(nc2c1)[C@H]1C[C@]2(C[C@@H](C2)NC(=O)c2ccc(o2)[S@](=O)CC2CC2)C1 InChI=1S/C23H23ClN2O4S/c24-15-3-4-18-17(7-15)26-22(30-18)14-8-23(9-14)10-16(11-23)25-21(27)19-5-6-20(29-19)31(28)12-13-1-2-13/h3-7,13-14,16H,1-2,8-12H2,(H,25,27)/t14-,16-,23-,31-/m1/s1 IGBLCXVNXCXYHT-MQRXBNLYSA-N 576392 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(cyclopropylmethylsulfinyl)furan-2-carboxamide::WO2022112207, Example 19-b External core antigen 53 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576392&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178065 474498598 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214624 Clc1ccc2oc(nc2c1)[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2ccc(o2)[S@@](=O)CC2CC2)C1 InChI=1S/C23H23ClN2O4S/c24-15-3-4-18-17(7-15)26-22(30-18)14-8-23(9-14)10-16(11-23)25-21(27)19-5-6-20(29-19)31(28)12-13-1-2-13/h3-7,13-14,16H,1-2,8-12H2,(H,25,27)/t14-,16-,23-,31-/m0/s1 IGBLCXVNXCXYHT-NESWQNMMSA-N 576393 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(cyclopropylmethylsulfinyl)furan-2-carboxamide::WO2022112207, Example 19-c External core antigen 1948 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576393&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178064 474498599 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214626 Clc1ccc2oc(nc2c1)[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2ccc(o2)[S@](=O)CC2CC2)C1 InChI=1S/C23H23ClN2O4S/c24-15-3-4-18-17(7-15)26-22(30-18)14-8-23(9-14)10-16(11-23)25-21(27)19-5-6-20(29-19)31(28)12-13-1-2-13/h3-7,13-14,16H,1-2,8-12H2,(H,25,27)/t14-,16-,23-,31+/m0/s1 IGBLCXVNXCXYHT-QPKGVIMWSA-N 576394 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(cyclopropylmethylsulfinyl)furan-2-carboxamide::WO2022112207, Example 19-d External core antigen 2499 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576394&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178065 474498600 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214628 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccc(o2)S(=O)(=O)CC2CC2)C1 InChI=1S/C23H23ClN2O5S/c24-15-3-4-18-17(7-15)26-22(31-18)14-8-23(9-14)10-16(11-23)25-21(27)19-5-6-20(30-19)32(28,29)12-13-1-2-13/h3-7,13-14,16H,1-2,8-12H2,(H,25,27) YNYVDDSFJZSDHP-UHFFFAOYSA-N 576395 N-[6-(5-chloro-1,3-benzoxazol-2-yl)spiro[3.3]heptan-2-yl]-5-(cyclopropylmethylsulfonyl)furan-2-carboxamide::WO2022112207, Example 20 External core antigen 180 WIPO 10.7270/Q2W380KC aid1806897 WO2022112207 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576395&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163379190 474498601 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214430 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccccn2)C1 InChI=1S/C20H18ClN3O2/c21-13-4-5-17-16(7-13)24-19(26-17)12-8-20(9-12)10-14(11-20)23-18(25)15-3-1-2-6-22-15/h1-7,12,14H,8-11H2,(H,23,25) ZVLCWADVPYDAKE-UHFFFAOYSA-N 576271 WO2022112140, Example 1 External core antigen 7890 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576271&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378966 474498479 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214432 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2cccnc2)C1 InChI=1S/C20H18ClN3O2/c21-14-3-4-17-16(6-14)24-19(26-17)13-7-20(8-13)9-15(10-20)23-18(25)12-2-1-5-22-11-12/h1-6,11,13,15H,7-10H2,(H,23,25) DZKFDRVCKWEUBB-UHFFFAOYSA-N 576296 WO2022112140, Example 2 External core antigen 5250 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576296&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378839 474498504 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214434 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccncc2)C1 InChI=1S/C20H18ClN3O2/c21-14-1-2-17-16(7-14)24-19(26-17)13-8-20(9-13)10-15(11-20)23-18(25)12-3-5-22-6-4-12/h1-7,13,15H,8-11H2,(H,23,25) JUVAZJWDYIGVHS-UHFFFAOYSA-N 576297 WO2022112140, Example 3 External core antigen 4390 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576297&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378863 474498505 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214436 Cc1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C21H20ClN3O2/c1-12-6-13(4-5-23-12)19(26)24-16-10-21(11-16)8-14(9-21)20-25-17-7-15(22)2-3-18(17)27-20/h2-7,14,16H,8-11H2,1H3,(H,24,26) BELQJBMLJDKTSG-UHFFFAOYSA-N 576298 WO2022112140, Example 4 External core antigen 4390 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576298&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378965 474498506 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214438 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccnc(NC3COC3)c2)C1 InChI=1S/C23H23ClN4O3/c24-15-1-2-19-18(6-15)28-22(31-19)14-7-23(8-14)9-16(10-23)27-21(29)13-3-4-25-20(5-13)26-17-11-30-12-17/h1-6,14,16-17H,7-12H2,(H,25,26)(H,27,29) UJDZQEHAHFPLAF-UHFFFAOYSA-N 576299 WO2022112140, Example 5 External core antigen 5420 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576299&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378929 474498507 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214440 CCN(CC)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C24H27ClN4O2/c1-3-29(4-2)21-9-15(7-8-26-21)22(30)27-18-13-24(14-18)11-16(12-24)23-28-19-10-17(25)5-6-20(19)31-23/h5-10,16,18H,3-4,11-14H2,1-2H3,(H,27,30) OSFAKEPYVJFPBF-UHFFFAOYSA-N 576300 WO2022112140, Example 6 External core antigen 4870 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576300&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378841 474498508 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214442 CCN(C)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C23H25ClN4O2/c1-3-28(2)20-8-14(6-7-25-20)21(29)26-17-12-23(13-17)10-15(11-23)22-27-18-9-16(24)4-5-19(18)30-22/h4-9,15,17H,3,10-13H2,1-2H3,(H,26,29) FUBLVRANLLDAIK-UHFFFAOYSA-N 576301 WO2022112140, Example 7 External core antigen 4340 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576301&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378864 474498509 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214444 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccnc(c2)N2CCCCC2)C1 InChI=1S/C25H27ClN4O2/c26-18-4-5-21-20(11-18)29-24(32-21)17-12-25(13-17)14-19(15-25)28-23(31)16-6-7-27-22(10-16)30-8-2-1-3-9-30/h4-7,10-11,17,19H,1-3,8-9,12-15H2,(H,28,31) XDDZXBIADYINTI-UHFFFAOYSA-N 576302 WO2022112140, Example 8 External core antigen 4050 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576302&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378972 474498510 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214446 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccnc(c2)N2CCOCC2)C1 InChI=1S/C24H25ClN4O3/c25-17-1-2-20-19(10-17)28-23(32-20)16-11-24(12-16)13-18(14-24)27-22(30)15-3-4-26-21(9-15)29-5-7-31-8-6-29/h1-4,9-10,16,18H,5-8,11-14H2,(H,27,30) KAVJUORVZZOUQN-UHFFFAOYSA-N 576303 WO2022112140, Example 9 External core antigen 4370 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576303&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378949 474498511 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214448 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccnc(NC3CC3)c2)C1 InChI=1S/C23H23ClN4O2/c24-15-1-4-19-18(8-15)28-22(30-19)14-9-23(10-14)11-17(12-23)27-21(29)13-5-6-25-20(7-13)26-16-2-3-16/h1,4-8,14,16-17H,2-3,9-12H2,(H,25,26)(H,27,29) DDEWHEGZWJFGNW-UHFFFAOYSA-N 576304 WO2022112140, Example 10 External core antigen 3920 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576304&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378955 474498512 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214450 CN(C)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C22H23ClN4O2/c1-27(2)19-7-13(5-6-24-19)20(28)25-16-11-22(12-16)9-14(10-22)21-26-17-8-15(23)3-4-18(17)29-21/h3-8,14,16H,9-12H2,1-2H3,(H,25,28) NSTQOTPVDNYMLM-UHFFFAOYSA-N 576305 WO2022112140, Example 11 External core antigen 2670 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576305&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378971 474498513 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214452 CC(C)N(C)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C24H27ClN4O2/c1-14(2)29(3)21-8-15(6-7-26-21)22(30)27-18-12-24(13-18)10-16(11-24)23-28-19-9-17(25)4-5-20(19)31-23/h4-9,14,16,18H,10-13H2,1-3H3,(H,27,30) SWMCQXVVDZPABU-UHFFFAOYSA-N 576306 WO2022112140, Example 12 External core antigen 1550 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576306&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378932 474498514 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214454 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccnc(c2)N2CCCC2=O)C1 InChI=1S/C24H23ClN4O3/c25-16-3-4-19-18(9-16)28-23(32-19)15-10-24(11-15)12-17(13-24)27-22(31)14-5-6-26-20(8-14)29-7-1-2-21(29)30/h3-6,8-9,15,17H,1-2,7,10-13H2,(H,27,31) ADHRIPIQEPJXAA-UHFFFAOYSA-N 576307 WO2022112140, Example 13 External core antigen 3940 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576307&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 166178038 474498515 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214456 Cc1csc(n1)-c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C24H21ClN4O2S/c1-13-12-32-23(27-13)19-6-14(4-5-26-19)21(30)28-17-10-24(11-17)8-15(9-24)22-29-18-7-16(25)2-3-20(18)31-22/h2-7,12,15,17H,8-11H2,1H3,(H,28,30) UFSCSAHRVKUDIN-UHFFFAOYSA-N 576308 WO2022112140, Example 14 External core antigen 4080 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576308&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378833 474498516 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214458 Cc1cnc(s1)-c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C24H21ClN4O2S/c1-13-12-27-23(32-13)19-6-14(4-5-26-19)21(30)28-17-10-24(11-17)8-15(9-24)22-29-18-7-16(25)2-3-20(18)31-22/h2-7,12,15,17H,8-11H2,1H3,(H,28,30) LKUQHTNJAHHHCK-UHFFFAOYSA-N 576309 WO2022112140, Example 15 External core antigen 1470 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576309&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378975 474498517 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214460 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccnc(c2)-c2nccs2)C1 InChI=1S/C23H19ClN4O2S/c24-15-1-2-19-17(8-15)28-21(30-19)14-9-23(10-14)11-16(12-23)27-20(29)13-3-4-25-18(7-13)22-26-5-6-31-22/h1-8,14,16H,9-12H2,(H,27,29) FWDPMMIEAODCOP-UHFFFAOYSA-N 576310 WO2022112140, Example 16 External core antigen 4730 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576310&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378827 474498518 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214462 COc1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C21H20ClN3O3/c1-27-18-6-12(4-5-23-18)19(26)24-15-10-21(11-15)8-13(9-21)20-25-16-7-14(22)2-3-17(16)28-20/h2-7,13,15H,8-11H2,1H3,(H,24,26) OLUMIYQMAXXCSQ-UHFFFAOYSA-N 576311 WO2022112140, Example 17 External core antigen 4480 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576311&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378816 474498519 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214464 Clc1ccc2oc(nc2c1)C1CC2(CC(C2)NC(=O)c2ccnc(c2)C#N)C1 InChI=1S/C21H17ClN4O2/c22-14-1-2-18-17(6-14)26-20(28-18)13-7-21(8-13)9-16(10-21)25-19(27)12-3-4-24-15(5-12)11-23/h1-6,13,16H,7-10H2,(H,25,27) BCWVAWIXMHEIGB-UHFFFAOYSA-N 576312 WO2022112140, Example 18 External core antigen 4870 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576312&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378910 474498520 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214466 NS(=O)(=O)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C20H19ClN4O4S/c21-13-1-2-16-15(6-13)25-19(29-16)12-7-20(8-12)9-14(10-20)24-18(26)11-3-4-23-17(5-11)30(22,27)28/h1-6,12,14H,7-10H2,(H,24,26)(H2,22,27,28) WCSZKIKAUHPTKT-UHFFFAOYSA-N 576313 WO2022112140, Example 19 External core antigen 1240 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576313&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378858 474498521 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214468 CC(C)Oc1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C23H24ClN3O3/c1-13(2)29-20-7-14(5-6-25-20)21(28)26-17-11-23(12-17)9-15(10-23)22-27-18-8-16(24)3-4-19(18)30-22/h3-8,13,15,17H,9-12H2,1-2H3,(H,26,28) QKLCXVLJRMECOB-UHFFFAOYSA-N 576314 WO2022112140, Example 20 External core antigen 1260 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576314&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378865 474498522 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214470 FC(F)(F)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C21H17ClF3N3O2/c22-13-1-2-16-15(6-13)28-19(30-16)12-7-20(8-12)9-14(10-20)27-18(29)11-3-4-26-17(5-11)21(23,24)25/h1-6,12,14H,7-10H2,(H,27,29) CVLOMUYDHIXHOW-UHFFFAOYSA-N 576315 WO2022112140, Example 21 External core antigen 1980 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576315&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378820 474498523 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214472 CNS(=O)(=O)Nc1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C21H22ClN5O4S/c1-23-32(29,30)27-18-6-12(4-5-24-18)19(28)25-15-10-21(11-15)8-13(9-21)20-26-16-7-14(22)2-3-17(16)31-20/h2-7,13,15,23H,8-11H2,1H3,(H,24,27)(H,25,28) RPJHDBRQTUOELY-UHFFFAOYSA-N 576316 WO2022112140, Example 22 External core antigen 4380 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576316&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378938 474498524 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214474 CS(=O)(=O)c1cc(ccn1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C21H20ClN3O4S/c1-30(27,28)18-6-12(4-5-23-18)19(26)24-15-10-21(11-15)8-13(9-21)20-25-16-7-14(22)2-3-17(16)29-20/h2-7,13,15H,8-11H2,1H3,(H,24,26) HCHWMNYNOZXCOB-UHFFFAOYSA-N 576317 WO2022112140, Example 23 External core antigen 490 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576317&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378870 474498525 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951 1214476 CS(=O)(=O)c1cncc(c1)C(=O)NC1CC2(C1)CC(C2)c1nc2cc(Cl)ccc2o1 InChI=1S/C21H20ClN3O4S/c1-30(27,28)16-4-12(10-23-11-16)19(26)24-15-8-21(9-15)6-13(7-21)20-25-17-5-14(22)2-3-18(17)29-20/h2-5,10-11,13,15H,6-9H2,1H3,(H,24,26) PBELFIOMFINMSH-UHFFFAOYSA-N 576318 WO2022112140, Example 24 External core antigen 3730 WIPO 10.7270/Q28D00HZ aid1806894 WO2022112140 Xianfeng, L; Hongying, Y; Bo, Z; Xiufang, Z F. HOFFMANN-LA ROCHE AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=576318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1312&target=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=576318&enzyme=External+core+antigen&column=ki&startPg=0&Increment=50&submit=Search 163378835 474498526 1 MQLFHLCLIISCSCPTVQASKLCLGWLLGMDIDPYKEFGASVELLSFLPSDFFPSVRDLLDTASALYREALESPEHCSPNHTALRQAVLCWGELMTGCSWVGNNLEDPASRELVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSPASQC External core antigen HBEAG_HBVGB P89951