BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1102209 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc3ccccc3)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C2=O InChI=1S/C55H74N8O12/c1-31(2)27-42-53(71)62(9)41(29-37-21-15-11-16-22-37)49(67)60-45(33(5)6)54(72)75-35(8)46(51(69)59-44(32(3)4)50(68)57-39-25-26-43(64)63(42)52(39)70)61-47(65)34(7)56-48(66)40(28-36-19-13-10-14-20-36)58-55(73)74-30-38-23-17-12-18-24-38/h10-24,31-35,39-46,64H,25-30H2,1-9H3,(H,56,66)(H,57,68)(H,58,73)(H,59,69)(H,60,67)(H,61,65)/t34-,35+,39-,40-,41-,42-,43+,44-,45-,46-/m0/s1 SNHYJFZBWGIANG-GNPCLWSFSA-N 521746 US11149067, Compound Ahp5 Serine protease HTRA3 [111-436] >50000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521746&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678043 461599121 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102215 CC(C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C InChI=1S/C52H68N8O12/c1-29(2)41-47(65)55-37-24-25-40(61)60(49(37)67)39(27-35-20-14-10-15-21-35)50(68)59(8)38(26-34-18-12-9-13-19-34)46(64)57-42(30(3)4)51(69)72-33(7)43(48(66)56-41)58-45(63)31(5)53-44(62)32(6)54-52(70)71-28-36-22-16-11-17-23-36/h9-23,29-33,37-43,61H,24-28H2,1-8H3,(H,53,62)(H,54,70)(H,55,65)(H,56,66)(H,57,64)(H,58,63)/t31-,32?,33+,37-,38-,39-,40+,41-,42-,43-/m0/s1 QBGDJDLPQVRMIP-GYBUNCRFSA-N 521747 US11149067, Compound Ahp6 Serine protease HTRA3 [111-436] >50000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521747&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678044 461599122 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102221 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](C)N(C)C1=O)C(C)C)C(C)C)C2=O InChI=1S/C43H66N8O12/c1-21(2)19-30-41(59)50(11)26(9)37(55)48-33(23(5)6)42(60)63-27(10)34(39(57)47-32(22(3)4)38(56)46-29-17-18-31(52)51(30)40(29)58)49-36(54)24(7)44-35(53)25(8)45-43(61)62-20-28-15-13-12-14-16-28/h12-16,21-27,29-34,52H,17-20H2,1-11H3,(H,44,53)(H,45,61)(H,46,56)(H,47,57)(H,48,55)(H,49,54)/t24-,25?,26-,27+,29-,30-,31+,32-,33-,34-/m0/s1 NTESMUWTZGMXHC-RAHQUKOBSA-N 521748 US11149067, Compound Ahp7 Serine protease HTRA3 [111-436] >50000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521748&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678045 461599123 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102227 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O InChI=1S/C53H70N8O12/c1-30(2)26-41-51(69)60(8)40(28-36-20-14-10-15-21-36)47(65)57-39(27-35-18-12-9-13-19-35)52(70)73-34(7)44(49(67)58-43(31(3)4)48(66)56-38-24-25-42(62)61(41)50(38)68)59-46(64)32(5)54-45(63)33(6)55-53(71)72-29-37-22-16-11-17-23-37/h9-23,30-34,38-44,62H,24-29H2,1-8H3,(H,54,63)(H,55,71)(H,56,66)(H,57,65)(H,58,67)(H,59,64)/t32-,33?,34+,38-,39-,40-,41-,42+,43-,44-/m0/s1 LGKBYPLVUOFARY-YVWHDEEASA-N 521749 US11149067, Compound Ahp8 Serine protease HTRA3 [111-436] 9500 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521749&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678046 461599124 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102233 CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C InChI=1S/C50H72N8O12/c1-27(2)23-36-44(62)53-35-21-22-39(59)58(47(35)65)38(24-28(3)4)48(66)57(10)37(25-33-17-13-11-14-18-33)45(63)55-40(29(5)6)49(67)70-32(9)41(46(64)54-36)56-43(61)30(7)51-42(60)31(8)52-50(68)69-26-34-19-15-12-16-20-34/h11-20,27-32,35-41,59H,21-26H2,1-10H3,(H,51,60)(H,52,68)(H,53,62)(H,54,64)(H,55,63)(H,56,61)/t30-,31?,32+,35-,36-,37-,38-,39+,40-,41-/m0/s1 PPBYPBROJYLVKD-VGWLHYIBSA-N 521750 US11149067, Compound Ahp9 Serine protease HTRA3 [111-436] >50000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521750&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678047 461599125 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102239 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@H](OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C(C)C)C2=O InChI=1S/C51H74N8O12/c1-27(2)24-37-49(67)58(11)36(25-33-18-14-12-15-19-33)45(63)56-40(29(5)6)50(68)71-42(30(7)8)41(47(65)55-39(28(3)4)46(64)54-35-22-23-38(60)59(37)48(35)66)57-44(62)31(9)52-43(61)32(10)53-51(69)70-26-34-20-16-13-17-21-34/h12-21,27-32,35-42,60H,22-26H2,1-11H3,(H,52,61)(H,53,69)(H,54,64)(H,55,65)(H,56,63)(H,57,62)/t31-,32?,35-,36-,37-,38+,39-,40-,41-,42+/m0/s1 LKRNBJJKOMCVND-URTNQIHRSA-N 521751 US11149067, Compound Ahp10 Serine protease HTRA3 [111-436] 480 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521751&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678048 461599126 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102243 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CCc3ccccc3)[C@H](OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C(C)C)C2=O InChI=1S/C49H71N7O10/c1-27(2)25-36-48(64)55(10)35(26-33-19-15-12-16-20-33)44(60)53-40(29(5)6)49(65)66-42(30(7)8)41(54-43(59)31(9)50-37(57)23-21-32-17-13-11-14-18-32)46(62)52-39(28(3)4)45(61)51-34-22-24-38(58)56(36)47(34)63/h11-20,27-31,34-36,38-42,58H,21-26H2,1-10H3,(H,50,57)(H,51,61)(H,52,62)(H,53,60)(H,54,59)/t31-,34-,35-,36-,38+,39-,40-,41-,42+/m0/s1 SBZWCIHPGYCKNC-KWWSHQCZSA-N 521752 US11149067, Compound Ahp11 Serine protease HTRA3 [111-436] 9500 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521752&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 146431906 461599127 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102246 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O InChI=1S/C47H66N8O12/c1-25(2)22-35-45(63)54(9)34(23-31-16-12-10-13-17-31)42(60)52-37(26(3)4)46(64)67-30(8)38(43(61)49-27(5)40(58)51-33-20-21-36(56)55(35)44(33)62)53-41(59)28(6)48-39(57)29(7)50-47(65)66-24-32-18-14-11-15-19-32/h10-19,25-30,33-38,56H,20-24H2,1-9H3,(H,48,57)(H,49,61)(H,50,65)(H,51,58)(H,52,60)(H,53,59)/t27-,28-,29?,30+,33-,34-,35-,36+,37-,38-/m0/s1 JSIYZGFHHUQOME-IGNZHVNOSA-N 521753 US11149067, Compound Ahp13 Serine protease HTRA3 [111-436] 980 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521753&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678049 461599128 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102250 CC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C InChI=1S/C48H68N8O12/c1-10-33-42(60)52-34-21-22-37(57)56(45(34)63)36(23-26(2)3)46(64)55(9)35(24-31-17-13-11-14-18-31)43(61)53-38(27(4)5)47(65)68-30(8)39(44(62)51-33)54-41(59)28(6)49-40(58)29(7)50-48(66)67-25-32-19-15-12-16-20-32/h11-20,26-30,33-39,57H,10,21-25H2,1-9H3,(H,49,58)(H,50,66)(H,51,62)(H,52,60)(H,53,61)(H,54,59)/t28-,29?,30+,33-,34-,35-,36-,37+,38-,39-/m0/s1 JIZUDYAGIUYWQX-YSZUJSJMSA-N 521754 US11149067, Compound Ahp14 Serine protease HTRA3 [111-436] 1460 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521754&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678050 461599129 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102254 CCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C InChI=1S/C49H70N8O12/c1-10-17-34-43(61)53-35-22-23-38(58)57(46(35)64)37(24-27(2)3)47(65)56(9)36(25-32-18-13-11-14-19-32)44(62)54-39(28(4)5)48(66)69-31(8)40(45(63)52-34)55-42(60)29(6)50-41(59)30(7)51-49(67)68-26-33-20-15-12-16-21-33/h11-16,18-21,27-31,34-40,58H,10,17,22-26H2,1-9H3,(H,50,59)(H,51,67)(H,52,63)(H,53,61)(H,54,62)(H,55,60)/t29-,30?,31+,34-,35-,36-,37-,38+,39-,40-/m0/s1 PHZGRASPIRNNKM-ZQQXXBJDSA-N 521755 US11149067, Compound Ahp15 Serine protease HTRA3 [111-436] >50000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521755&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678051 461599130 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102258 CCC(C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc2ccccc2)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(C)C)N2[C@H](O)CC[C@H](NC1=O)C2=O)C(C)C InChI=1S/C50H72N8O12/c1-11-29(6)40-45(63)53-35-22-23-38(59)58(47(35)65)37(24-27(2)3)48(66)57(10)36(25-33-18-14-12-15-19-33)44(62)54-39(28(4)5)49(67)70-32(9)41(46(64)55-40)56-43(61)30(7)51-42(60)31(8)52-50(68)69-26-34-20-16-13-17-21-34/h12-21,27-32,35-41,59H,11,22-26H2,1-10H3,(H,51,60)(H,52,68)(H,53,63)(H,54,62)(H,55,64)(H,56,61)/t29?,30-,31?,32+,35-,36-,37-,38+,39-,40-,41-/m0/s1 RUCGKLRHNMBJDK-ACQXFLQYSA-N 521756 US11149067, Compound Ahp16 Serine protease HTRA3 [111-436] >50000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521756&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678052 461599131 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102262 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@H](CC=C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O InChI=1S/C49H68N8O12/c1-10-17-34-43(61)53-35-22-23-38(58)57(46(35)64)37(24-27(2)3)47(65)56(9)36(25-32-18-13-11-14-19-32)44(62)54-39(28(4)5)48(66)69-31(8)40(45(63)52-34)55-42(60)29(6)50-41(59)30(7)51-49(67)68-26-33-20-15-12-16-21-33/h10-16,18-21,27-31,34-40,58H,1,17,22-26H2,2-9H3,(H,50,59)(H,51,67)(H,52,63)(H,53,61)(H,54,62)(H,55,60)/t29-,30?,31+,34-,35-,36-,37-,38+,39-,40-/m0/s1 UEEPUAFBVYYSEV-ZQQXXBJDSA-N 521757 US11149067, Compound Ahp17 Serine protease HTRA3 [111-436] 840 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521757&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678053 461599132 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102265 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@H](CC#C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O InChI=1S/C49H66N8O12/c1-10-17-34-43(61)53-35-22-23-38(58)57(46(35)64)37(24-27(2)3)47(65)56(9)36(25-32-18-13-11-14-19-32)44(62)54-39(28(4)5)48(66)69-31(8)40(45(63)52-34)55-42(60)29(6)50-41(59)30(7)51-49(67)68-26-33-20-15-12-16-21-33/h1,11-16,18-21,27-31,34-40,58H,17,22-26H2,2-9H3,(H,50,59)(H,51,67)(H,52,63)(H,53,61)(H,54,62)(H,55,60)/t29-,30?,31+,34-,35-,36-,37-,38+,39-,40-/m0/s1 UPTMZYCNHSIAMF-ZQQXXBJDSA-N 521758 US11149067, Compound Ahp18 Serine protease HTRA3 [111-436] 17900 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521758&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678054 461599133 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102269 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C1CC1)C2=O InChI=1S/C49H68N8O12/c1-26(2)23-36-47(65)56(8)35(24-31-15-11-9-12-16-31)43(61)53-38(27(3)4)48(66)69-30(7)39(44(62)55-40(33-19-20-33)45(63)52-34-21-22-37(58)57(36)46(34)64)54-42(60)28(5)50-41(59)29(6)51-49(67)68-25-32-17-13-10-14-18-32/h9-18,26-30,33-40,58H,19-25H2,1-8H3,(H,50,59)(H,51,67)(H,52,63)(H,53,61)(H,54,60)(H,55,62)/t28-,29?,30+,34-,35-,36-,37+,38-,39-,40-/m0/s1 FBVHNEJHUKHIRN-JPUUQCNTSA-N 521759 US11149067, Compound Ahp19 Serine protease HTRA3 [111-436] 740 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521759&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678055 461599134 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102273 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)(C)C)C2=O InChI=1S/C50H72N8O12/c1-27(2)24-36-47(66)57(11)35(25-32-18-14-12-15-19-32)43(62)54-38(28(3)4)48(67)70-31(7)39(44(63)56-40(50(8,9)10)45(64)53-34-22-23-37(59)58(36)46(34)65)55-42(61)29(5)51-41(60)30(6)52-49(68)69-26-33-20-16-13-17-21-33/h12-21,27-31,34-40,59H,22-26H2,1-11H3,(H,51,60)(H,52,68)(H,53,64)(H,54,62)(H,55,61)(H,56,63)/t29-,30?,31+,34-,35-,36-,37+,38-,39-,40+/m0/s1 CQRABNMMZWKMHK-LPBSJKRESA-N 521760 US11149067, Compound Ahp20 Serine protease HTRA3 [111-436] 8300 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521760&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678056 461599135 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102277 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C1CCCCC1)C2=O InChI=1S/C52H74N8O12/c1-29(2)26-39-50(68)59(8)38(27-34-18-12-9-13-19-34)46(64)56-41(30(3)4)51(69)72-33(7)42(57-45(63)31(5)53-44(62)32(6)54-52(70)71-28-35-20-14-10-15-21-35)47(65)58-43(36-22-16-11-17-23-36)48(66)55-37-24-25-40(61)60(39)49(37)67/h9-10,12-15,18-21,29-33,36-43,61H,11,16-17,22-28H2,1-8H3,(H,53,62)(H,54,70)(H,55,66)(H,56,64)(H,57,63)(H,58,65)/t31-,32?,33+,37-,38-,39-,40+,41-,42-,43-/m0/s1 CNUQUBIKESRQSE-GYBUNCRFSA-N 521761 US11149067, Compound Ahp21 Serine protease HTRA3 [111-436] >50000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521761&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678057 461599136 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102185 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C2=O InChI=1S/C49H70N8O12/c1-26(2)23-36-47(65)56(10)35(24-32-17-13-11-14-18-32)43(61)54-39(28(5)6)48(66)69-31(9)40(45(63)53-38(27(3)4)44(62)52-34-21-22-37(58)57(36)46(34)64)55-42(60)29(7)50-41(59)30(8)51-49(67)68-25-33-19-15-12-16-20-33/h11-20,26-31,34-40,58H,21-25H2,1-10H3,(H,50,59)(H,51,67)(H,52,62)(H,53,63)(H,54,61)(H,55,60)/t29-,30?,31+,34-,35-,36-,37+,38-,39-,40-/m0/s1 OZFGZIUGZVQVRM-KTEXAARISA-N 521742 US11149067, Compound Ahp1 Serine protease HTRA3 [111-436] 3000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521742&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678039 461599117 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102191 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C2=O InChI=1S/C53H70N8O12/c1-30(2)26-41-51(69)60(8)40(28-36-20-14-10-15-21-36)48(66)58-43(31(3)4)52(70)73-34(7)44(59-46(64)32(5)54-45(63)33(6)55-53(71)72-29-37-22-16-11-17-23-37)49(67)57-39(27-35-18-12-9-13-19-35)47(65)56-38-24-25-42(62)61(41)50(38)68/h9-23,30-34,38-44,62H,24-29H2,1-8H3,(H,54,63)(H,55,71)(H,56,65)(H,57,67)(H,58,66)(H,59,64)/t32-,33?,34+,38-,39-,40-,41-,42+,43-,44-/m0/s1 KSIIQMVMFXSAAT-YVWHDEEASA-N 521743 US11149067, Compound Ahp2 Serine protease HTRA3 [111-436] >50000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521743&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678040 461599118 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102197 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@H](OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)c1ccccc1)C(C)C)C2=O InChI=1S/C54H72N8O12/c1-30(2)27-40-52(70)61(9)39(28-35-19-13-10-14-20-35)48(66)59-43(32(5)6)53(71)74-45(37-23-17-12-18-24-37)44(50(68)58-42(31(3)4)49(67)57-38-25-26-41(63)62(40)51(38)69)60-47(65)33(7)55-46(64)34(8)56-54(72)73-29-36-21-15-11-16-22-36/h10-24,30-34,38-45,63H,25-29H2,1-9H3,(H,55,64)(H,56,72)(H,57,67)(H,58,68)(H,59,66)(H,60,65)/t33-,34?,38-,39-,40-,41+,42-,43-,44-,45+/m0/s1 CNUQWXKBOTXSTQ-SHRLYCCHSA-N 521744 US11149067, Compound Ahp3 Serine protease HTRA3 [111-436] 3100 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521744&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678041 461599119 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2 1102203 CC(C)C[C@@H]1N2[C@H](O)CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)C(C)NC(=O)OCc3ccccc3)[C@@H](C)OC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C1=O)C(C)C)C(C)C)C2=O InChI=1S/C55H74N8O12/c1-31(2)27-42-53(71)62(9)41(29-37-21-15-11-16-22-37)49(67)60-45(33(5)6)54(72)75-35(8)46(51(69)59-44(32(3)4)50(68)57-39-25-26-43(64)63(42)52(39)70)61-48(66)40(28-36-19-13-10-14-20-36)58-47(65)34(7)56-55(73)74-30-38-23-17-12-18-24-38/h10-24,31-35,39-46,64H,25-30H2,1-9H3,(H,56,73)(H,57,68)(H,58,65)(H,59,69)(H,60,67)(H,61,66)/t34?,35-,39+,40+,41+,42+,43-,44+,45+,46+/m1/s1 UTEFZPPMNAQVQL-LUWCDXLHSA-N 521745 US11149067, Compound Ahp4 Serine protease HTRA3 [111-436] >50000 US Patent 10.7270/Q2RR22D0 aid1806013 US11149067 Kaiser, M; Kocher, S; Rey, J; Bongard, J; Ehrmann, M; Resch, S UNIVERSITÄT DUISBURG-ESSEN http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=521745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1144&target=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=521745&enzyme=Serine+protease+HTRA3+%5B111-436%5D&column=ki&startPg=0&Increment=50&submit=Search 162678042 461599120 1 LQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEV 2P3W Serine protease HTRA3 HTRA3_HUMAN P83110 Q7Z7A2