BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1094403 CN[C@@H](C)C(=O)N[C@H]1CO[C@H]2CCC(N2C1=O)C(=O)Nc1ccc(OC)cc1 InChI=1S/C19H26N4O5/c1-11(20-2)17(24)22-14-10-28-16-9-8-15(23(16)19(14)26)18(25)21-12-4-6-13(27-3)7-5-12/h4-7,11,14-16,20H,8-10H2,1-3H3,(H,21,25)(H,22,24)/t11-,14-,15?,16-/m0/s1 NBMUDTIUNPDSAM-OLSVDGPUSA-N 391807 US10300074, Compd 3::US10300074, Compd 4::US10300074, Compd 7::US11111270, Compound 7 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391807&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201990 404960171 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094405 CNC(C)C(=O)N[C@H]1CO[C@H]2CCC(N2C1=O)C(=O)Nc1ccc(OC)cc1 InChI=1S/C19H26N4O5/c1-11(20-2)17(24)22-14-10-28-16-9-8-15(23(16)19(14)26)18(25)21-12-4-6-13(27-3)7-5-12/h4-7,11,14-16,20H,8-10H2,1-3H3,(H,21,25)(H,22,24)/t11?,14-,15?,16-/m0/s1 NBMUDTIUNPDSAM-XTPYGBJTSA-N 518256 US11111270, Compound 4 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518256&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 162678447 461604280 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094407 CN[C@@H](C)C(=O)N[C@H]1CO[C@H]2CCC(N2C1=O)C(=O)NCc1ccccc1 InChI=1S/C19H26N4O4/c1-12(20-2)17(24)22-14-11-27-16-9-8-15(23(16)19(14)26)18(25)21-10-13-6-4-3-5-7-13/h3-7,12,14-16,20H,8-11H2,1-2H3,(H,21,25)(H,22,24)/t12-,14-,15?,16-/m0/s1 JVKFFBGNOJIZCH-IIQYYHDJSA-N 391809 US10300074, Compd 5::US10300074, Compd 6::US11111270, Compound 6 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391809&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90190770 404960172 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094409 CN[C@@H](C)C(=O)N[C@H]1CO[C@H]2CCC(N2C1=O)C(=O)NCc1ccccc1 InChI=1S/C19H26N4O4/c1-12(20-2)17(24)22-14-11-27-16-9-8-15(23(16)19(14)26)18(25)21-10-13-6-4-3-5-7-13/h3-7,12,14-16,20H,8-11H2,1-2H3,(H,21,25)(H,22,24)/t12-,14-,15?,16-/m0/s1 JVKFFBGNOJIZCH-IIQYYHDJSA-N 391809 US10300074, Compd 5::US10300074, Compd 6::US11111270, Compound 6 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391809&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90190770 404960172 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094411 CN[C@@H](C)C(=O)N[C@H]1CO[C@H]2CCC(N2C1=O)C(=O)Nc1ccc(OC)cc1 InChI=1S/C19H26N4O5/c1-11(20-2)17(24)22-14-10-28-16-9-8-15(23(16)19(14)26)18(25)21-12-4-6-13(27-3)7-5-12/h4-7,11,14-16,20H,8-10H2,1-3H3,(H,21,25)(H,22,24)/t11-,14-,15?,16-/m0/s1 NBMUDTIUNPDSAM-OLSVDGPUSA-N 391807 US10300074, Compd 3::US10300074, Compd 4::US10300074, Compd 7::US11111270, Compound 7 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391807&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201990 404960171 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094413 CN[C@@H](C)C(=O)N[C@H]1CO[C@H]2CCC(N2C1=O)C(=O)Nc1ccc(Cl)cc1 InChI=1S/C18H23ClN4O4/c1-10(20-2)16(24)22-13-9-27-15-8-7-14(23(15)18(13)26)17(25)21-12-5-3-11(19)4-6-12/h3-6,10,13-15,20H,7-9H2,1-2H3,(H,21,25)(H,22,24)/t10-,13-,14?,15-/m0/s1 CMRJIHMIAAPULE-LGEGPZQVSA-N 391812 US10300074, Compd 8::US11111270, Compound 8 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391812&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90190855 404960173 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094415 CN[C@@H](C)C(=O)N[C@H]1CO[C@H]2CCC(N2C1=O)C(=O)NC1CCCc2ccccc12 InChI=1S/C22H30N4O4/c1-13(23-2)20(27)25-17-12-30-19-11-10-18(26(19)22(17)29)21(28)24-16-9-5-7-14-6-3-4-8-15(14)16/h3-4,6,8,13,16-19,23H,5,7,9-12H2,1-2H3,(H,24,28)(H,25,27)/t13-,16?,17-,18?,19-/m0/s1 IJPZPWFXNFKMBF-LFQJEHLWSA-N 391813 US10300074, Compd 9::US11111270, Compound 9 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391813&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 126712467 404960174 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094417 CN[C@@H](C)C(=O)N[C@H]1[C@@H](C)O[C@H]2CCC(N2C1=O)C(=O)NC1CCCc2ccccc12 InChI=1S/C23H32N4O4/c1-13(24-3)21(28)26-20-14(2)31-19-12-11-18(27(19)23(20)30)22(29)25-17-10-6-8-15-7-4-5-9-16(15)17/h4-5,7,9,13-14,17-20,24H,6,8,10-12H2,1-3H3,(H,25,29)(H,26,28)/t13-,14+,17?,18?,19-,20-/m0/s1 MPNOJWOXEWYDRH-ATCZTYQISA-N 391814 US10300074, Compd 10::US11111270, Compound 10 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391814&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 129903698 404960175 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094420 CN[C@@H](C)C(=O)N[C@H]1[C@@H](C)O[C@H]2CCC(N2C1=O)C(=O)Nc1cccc2ccccc12 InChI=1S/C23H28N4O4/c1-13(24-3)21(28)26-20-14(2)31-19-12-11-18(27(19)23(20)30)22(29)25-17-10-6-8-15-7-4-5-9-16(15)17/h4-10,13-14,18-20,24H,11-12H2,1-3H3,(H,25,29)(H,26,28)/t13-,14+,18?,19-,20-/m0/s1 RZJDMCUSSGJZOI-FVVJRULNSA-N 391815 US10300074, Compd 11::US11111270, Compound 11 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391815&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90190669 404960176 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094422 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C23H32N4O4/c1-14(24-2)21(28)26-18-12-13-31-20-11-10-19(27(20)23(18)30)22(29)25-17-9-5-7-15-6-3-4-8-16(15)17/h3-4,6,8,14,17-20,24H,5,7,9-13H2,1-2H3,(H,25,29)(H,26,28)/t14-,17+,18-,19?,20-/m0/s1 DGUZQZXTUHDVHK-JVYSIHQFSA-N 391816 US10300074, Compd 12::US11111270, Compound 12 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391816&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071233 404960177 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094425 CN[C@@H](C)C(=O)NC1CCO[C@H]2CCC(N2C1=O)C(=O)Nc1cccc2ccccc12 InChI=1S/C23H28N4O4/c1-14(24-2)21(28)26-18-12-13-31-20-11-10-19(27(20)23(18)30)22(29)25-17-9-5-7-15-6-3-4-8-16(15)17/h3-9,14,18-20,24H,10-13H2,1-2H3,(H,25,29)(H,26,28)/t14-,18?,19?,20-/m0/s1 XTWCHYNJYPOFBR-XHNVJUCFSA-N 518266 US11111270, Compound 13 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518266&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 126712377 461604290 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094427 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CCC(N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1 InChI=1S/C26H32N4O4/c1-17(27-2)24(31)28-20-15-16-34-22-14-13-21(30(22)26(20)33)25(32)29-23(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,20-23,27H,13-16H2,1-2H3,(H,28,31)(H,29,32)/t17-,20-,21?,22-/m0/s1 KOGGGAUQFHJPPH-ABQJZZKHSA-N 391819 US10300074, Compd 14::US11111270, Compound 14 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391819&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071348 404960180 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094430 CN[C@@H](C)C(=O)N[C@H]1[C@@H](C)O[C@H]2CCC(N2C1=O)C(=O)NC(c1ccccc1)c1ccccc1 InChI=1S/C26H32N4O4/c1-16(27-3)24(31)28-22-17(2)34-21-15-14-20(30(21)26(22)33)25(32)29-23(18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13,16-17,20-23,27H,14-15H2,1-3H3,(H,28,31)(H,29,32)/t16-,17+,20?,21-,22-/m0/s1 JTUKOFSAWIHEHS-HNYVQNJRSA-N 391820 US10300074, Compd 15::US11111270, Compound 15 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391820&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201968 404960181 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094432 CN[C@@H](C)C(=O)N[C@H]1CCCNC2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C24H35N5O3/c1-15(25-2)22(30)28-19-11-6-14-26-21-13-12-20(29(21)24(19)32)23(31)27-18-10-5-8-16-7-3-4-9-17(16)18/h3-4,7,9,15,18-21,25-26H,5-6,8,10-14H2,1-2H3,(H,27,31)(H,28,30)/t15-,18+,19-,20?,21?/m0/s1 RYBZPXRGSOWIAP-QFKUQALRSA-N 518274 US11111270, Compound 16 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518274&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201959 461604297 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094434 CN[C@@H](C)C(=O)N[C@H]1CCCNC2CCC(N2C1=O)C(=O)Nc1cccc2ccccc12 InChI=1S/C24H31N5O3/c1-15(25-2)22(30)28-19-11-6-14-26-21-13-12-20(29(21)24(19)32)23(31)27-18-10-5-8-16-7-3-4-9-17(16)18/h3-5,7-10,15,19-21,25-26H,6,11-14H2,1-2H3,(H,27,31)(H,28,30)/t15-,19-,20?,21?/m0/s1 SGCOICSZDJXTOO-SGRCFUTNSA-N 518275 US11111270, Compound 17 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518275&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201999 461604298 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094436 C[C@H](N(C)C(C)=O)C(=O)N[C@H]1CCCN([C@H]2CCC(N2C1=O)C(=O)Nc1cccc2ccccc12)C(C)=O InChI=1S/C28H35N5O5/c1-17(31(4)18(2)34)26(36)30-23-13-8-16-32(19(3)35)25-15-14-24(33(25)28(23)38)27(37)29-22-12-7-10-20-9-5-6-11-21(20)22/h5-7,9-12,17,23-25H,8,13-16H2,1-4H3,(H,29,37)(H,30,36)/t17-,23-,24?,25+/m0/s1 ILMZGDJBGWZLET-LMJNJGBBSA-N 518278 US11111270, Compound 18::US11111270, Compound 19 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518278&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201960 461604301 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094438 C[C@H](N(C)C(C)=O)C(=O)N[C@H]1CCCN([C@H]2CCC(N2C1=O)C(=O)Nc1cccc2ccccc12)C(C)=O InChI=1S/C28H35N5O5/c1-17(31(4)18(2)34)26(36)30-23-13-8-16-32(19(3)35)25-15-14-24(33(25)28(23)38)27(37)29-22-12-7-10-20-9-5-6-11-21(20)22/h5-7,9-12,17,23-25H,8,13-16H2,1-4H3,(H,29,37)(H,30,36)/t17-,23-,24?,25+/m0/s1 ILMZGDJBGWZLET-LMJNJGBBSA-N 518278 US11111270, Compound 18::US11111270, Compound 19 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518278&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201960 461604301 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094440 CN[C@@H](C)C(=O)N[C@H]1CCCN(C2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12)C(C)=O InChI=1S/C26H37N5O4/c1-16(27-3)24(33)29-21-12-7-15-30(17(2)32)23-14-13-22(31(23)26(21)35)25(34)28-20-11-6-9-18-8-4-5-10-19(18)20/h4-5,8,10,16,20-23,27H,6-7,9,11-15H2,1-3H3,(H,28,34)(H,29,33)/t16-,20+,21-,22?,23?/m0/s1 GQKHBNWZSAKNGT-PEEKZLGLSA-N 518282 US11111270, Compound 20::US11111270, Compound 21 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518282&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 126712460 461604304 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094442 CN[C@@H](C)C(=O)N[C@H]1CCCN(C2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12)C(C)=O InChI=1S/C26H37N5O4/c1-16(27-3)24(33)29-21-12-7-15-30(17(2)32)23-14-13-22(31(23)26(21)35)25(34)28-20-11-6-9-18-8-4-5-10-19(18)20/h4-5,8,10,16,20-23,27H,6-7,9,11-15H2,1-3H3,(H,28,34)(H,29,33)/t16-,20+,21-,22?,23?/m0/s1 GQKHBNWZSAKNGT-PEEKZLGLSA-N 518282 US11111270, Compound 20::US11111270, Compound 21 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518282&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 126712460 461604304 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094444 CN[C@@H](C)C(=O)NC1CCO[C@H]2CC[C@@H](N2C1=O)C(=O)n1ccc2ccccc12 InChI=1S/C21H26N4O4/c1-13(22-2)19(26)23-15-10-12-29-18-8-7-17(25(18)20(15)27)21(28)24-11-9-14-5-3-4-6-16(14)24/h3-6,9,11,13,15,17-18,22H,7-8,10,12H2,1-2H3,(H,23,26)/t13-,15?,17+,18-/m0/s1 MVTULAMVOISCBR-HWGXEKPZSA-N 518284 US11111270, Compound 22 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518284&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 126712376 461604305 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094446 CN[C@@H](C)C(=O)NC1CCO[C@H]2CC[C@H](N2C1=O)C(=O)n1ccc2ccccc12 InChI=1S/C21H26N4O4/c1-13(22-2)19(26)23-15-10-12-29-18-8-7-17(25(18)20(15)27)21(28)24-11-9-14-5-3-4-6-16(14)24/h3-6,9,11,13,15,17-18,22H,7-8,10,12H2,1-2H3,(H,23,26)/t13-,15?,17-,18-/m0/s1 MVTULAMVOISCBR-FIXJOCNVSA-N 518285 US11111270, Compound 23 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518285&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 126712495 461604306 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094448 CN[C@@H](C)C(=O)N[C@H]1CCS[C@H]2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C23H32N4O3S/c1-14(24-2)21(28)26-18-12-13-31-20-11-10-19(27(20)23(18)30)22(29)25-17-9-5-7-15-6-3-4-8-16(15)17/h3-4,6,8,14,17-20,24H,5,7,9-13H2,1-2H3,(H,25,29)(H,26,28)/t14-,17+,18-,19?,20-/m0/s1 GRPYHMFJRWZUEE-JVYSIHQFSA-N 518286 US11111270, Compound 24 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518286&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071234 461604307 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094451 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC[C@H](N2C1=O)C(=O)Nc1cccc2ccccc12 InChI=1S/C23H28N4O4/c1-14(24-2)21(28)26-18-12-13-31-20-11-10-19(27(20)23(18)30)22(29)25-17-9-5-7-15-6-3-4-8-16(15)17/h3-9,14,18-20,24H,10-13H2,1-2H3,(H,25,29)(H,26,28)/t14-,18-,19-,20-/m0/s1 XTWCHYNJYPOFBR-DSYPUSFNSA-N 391830 US10300074, Compd 25::US11111270, Compound 25 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391830&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201949 404960188 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094453 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)[C@H](N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C25H36N4O4/c1-15(26-4)22(30)28-19-12-13-33-20-14-25(2,3)21(29(20)24(19)32)23(31)27-18-11-7-9-16-8-5-6-10-17(16)18/h5-6,8,10,15,18-21,26H,7,9,11-14H2,1-4H3,(H,27,31)(H,28,30)/t15-,18+,19-,20-,21+/m0/s1 PBGOFGSVVXGJCA-KDJJVYBXSA-N 391831 US10300074, Compd 26::US11111270, Compound 26 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391831&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071591 404960189 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094456 CN[C@@H](C)C(=O)N[C@H]1CCO[C@@H]2N(C(C(=O)N[C@@H]3CCCc4ccccc34)c3ccccc23)C1=O InChI=1S/C27H32N4O4/c1-16(28-2)24(32)30-22-14-15-35-27-20-12-6-5-11-19(20)23(31(27)26(22)34)25(33)29-21-13-7-9-17-8-3-4-10-18(17)21/h3-6,8,10-12,16,21-23,27-28H,7,9,13-15H2,1-2H3,(H,29,33)(H,30,32)/t16-,21+,22-,23?,27-/m0/s1 SRRKQOXMYDWYGT-MVCZWWRHSA-N 391804 US10300074, Product 17a::US11111270, Compound 27 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391804&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201950 404960168 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094459 CN[C@@H](C)C(=O)N[C@H]1CCN[C@H]2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C23H33N5O3/c1-14(24-2)21(29)27-18-12-13-25-20-11-10-19(28(20)23(18)31)22(30)26-17-9-5-7-15-6-3-4-8-16(15)17/h3-4,6,8,14,17-20,24-25H,5,7,9-13H2,1-2H3,(H,26,30)(H,27,29)/t14-,17+,18-,19?,20+/m0/s1 YYQVMLJSZUXZFS-LREMNVJNSA-N 518307 US11111270, Compound 28::US11111270, Compound 29 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518307&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071474 461604328 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094461 CN[C@@H](C)C(=O)N[C@H]1CCN[C@H]2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C23H33N5O3/c1-14(24-2)21(29)27-18-12-13-25-20-11-10-19(28(20)23(18)31)22(30)26-17-9-5-7-15-6-3-4-8-16(15)17/h3-4,6,8,14,17-20,24-25H,5,7,9-13H2,1-2H3,(H,26,30)(H,27,29)/t14-,17+,18-,19?,20+/m0/s1 YYQVMLJSZUXZFS-LREMNVJNSA-N 518307 US11111270, Compound 28::US11111270, Compound 29 E3 ubiquitin-protein ligase XIAP [265-330] >50000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518307&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071474 461604328 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094463 CN[C@@H](C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)[C@H]2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 391835 US10300074, Compd 30::US10300074, Compd 31::US11111270, Compound 31 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391835&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071349 404960192 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094465 CN[C@@H](C)C(=O)N[C@H]1Cc2c([nH]c3ccccc23)[C@H]2CCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 391835 US10300074, Compd 30::US10300074, Compd 31::US11111270, Compound 31 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391835&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071349 404960192 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094467 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC[C@H](N2C1=O)C(=O)N[C@@H]1CCOc2ccccc12 InChI=1S/C22H30N4O5/c1-13(23-2)20(27)25-16-10-12-31-19-8-7-17(26(19)22(16)29)21(28)24-15-9-11-30-18-6-4-3-5-14(15)18/h3-6,13,15-17,19,23H,7-12H2,1-2H3,(H,24,28)(H,25,27)/t13-,15+,16-,17-,19-/m0/s1 FOZRDSOEUULRIC-CICISYLWSA-N 391837 US10300074, Compd 32::US11111270, Compound 32 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391837&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201954 404960193 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094470 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC[C@H](N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C23H32N4O4/c1-14(24-2)21(28)26-18-12-13-31-20-11-10-19(27(20)23(18)30)22(29)25-17-9-5-7-15-6-3-4-8-16(15)17/h3-4,6,8,14,17-20,24H,5,7,9-13H2,1-2H3,(H,25,29)(H,26,28)/t14-,17+,18-,19-,20-/m0/s1 DGUZQZXTUHDVHK-IQOMPXODSA-N 391838 US10300074, Compd 33::US11111270, Compound 33 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391838&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071472 404960194 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094473 CN[C@@H](C)C(=O)N[C@H]1CCS[C@H]2CC[C@H](N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C23H32N4O3S/c1-14(24-2)21(28)26-18-12-13-31-20-11-10-19(27(20)23(18)30)22(29)25-17-9-5-7-15-6-3-4-8-16(15)17/h3-4,6,8,14,17-20,24H,5,7,9-13H2,1-2H3,(H,25,29)(H,26,28)/t14-,17+,18-,19-,20-/m0/s1 GRPYHMFJRWZUEE-IQOMPXODSA-N 391839 US10300074, Compd 34::US11111270, Compound 34 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391839&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071475 404960195 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094476 CN[C@@H](C)C(=O)N[C@H]1CCS[C@H]2CC(C)(C)C(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C25H36N4O3S/c1-15(26-4)22(30)28-19-12-13-33-20-14-25(2,3)21(29(20)24(19)32)23(31)27-18-11-7-9-16-8-5-6-10-17(16)18/h5-6,8,10,15,18-21,26H,7,9,11-14H2,1-4H3,(H,27,31)(H,28,30)/t15-,18+,19-,20-,21?/m0/s1 IIXXVAXNYFQXST-DUDGCXMLSA-N 391806 US10300074, Product 17c::US11111270, Compound 35 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391806&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 74538665 404960170 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094479 CN[C@@H](C)C(=O)N[C@H]1CCS[C@H]2CC[C@@H](N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C23H32N4O3S/c1-14(24-2)21(28)26-18-12-13-31-20-11-10-19(27(20)23(18)30)22(29)25-17-9-5-7-15-6-3-4-8-16(15)17/h3-4,6,8,14,17-20,24H,5,7,9-13H2,1-2H3,(H,25,29)(H,26,28)/t14-,17+,18-,19+,20-/m0/s1 GRPYHMFJRWZUEE-AXBXVSCFSA-N 391841 US10300074, Compd 36::US11111270, Compound 36 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391841&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071352 404960197 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094482 CN[C@@H](C)C(=O)N[C@H]1CCS(=O)(=O)[C@H]2CC[C@H](N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C23H32N4O5S/c1-14(24-2)21(28)26-18-12-13-33(31,32)20-11-10-19(27(20)23(18)30)22(29)25-17-9-5-7-15-6-3-4-8-16(15)17/h3-4,6,8,14,17-20,24H,5,7,9-13H2,1-2H3,(H,25,29)(H,26,28)/t14-,17+,18-,19-,20-/m0/s1 NQKSLNVTSSRSHW-IQOMPXODSA-N 391842 US10300074, Compd 37::US11111270, Compound 37 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391842&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071476 404960198 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094484 CN[C@@H](C)C(=O)N[C@H]1CCS(=O)(=O)[C@H]2CC[C@@H](N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C23H32N4O5S/c1-14(24-2)21(28)26-18-12-13-33(31,32)20-11-10-19(27(20)23(18)30)22(29)25-17-9-5-7-15-6-3-4-8-16(15)17/h3-4,6,8,14,17-20,24H,5,7,9-13H2,1-2H3,(H,25,29)(H,26,28)/t14-,17+,18-,19+,20-/m0/s1 NQKSLNVTSSRSHW-AXBXVSCFSA-N 391843 US10300074, Compd 38::US11111270, Compound 38 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391843&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071471 404960199 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094486 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC[C@@H](N2C1=O)C(=O)N[C@@H]1CCOc2ccccc12 InChI=1S/C22H30N4O5/c1-13(23-2)20(27)25-16-10-12-31-19-8-7-17(26(19)22(16)29)21(28)24-15-9-11-30-18-6-4-3-5-14(15)18/h3-6,13,15-17,19,23H,7-12H2,1-2H3,(H,24,28)(H,25,27)/t13-,15+,16-,17+,19-/m0/s1 FOZRDSOEUULRIC-BJZZIADLSA-N 391844 US10300074, Compd 39::US11111270, Compound 39 E3 ubiquitin-protein ligase XIAP [265-330] 37500 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391844&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201941 404960200 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094488 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC(C)(C)C(N2C1=O)C(=O)Nc1ccccc1SSc1ccccc1NC(=O)C1N2[C@H](CC1(C)C)OCC[C@H](NC(=O)[C@H](C)NC)C2=O InChI=1S/C42H58N8O8S2/c1-23(43-7)35(51)47-27-17-19-57-31-21-41(3,4)33(49(31)39(27)55)37(53)45-25-13-9-11-15-29(25)59-60-30-16-12-10-14-26(30)46-38(54)34-42(5,6)22-32-50(34)40(56)28(18-20-58-32)48-36(52)24(2)44-8/h9-16,23-24,27-28,31-34,43-44H,17-22H2,1-8H3,(H,45,53)(H,46,54)(H,47,51)(H,48,52)/t23-,24-,27-,28-,31-,32-,33?,34?/m0/s1 AIFGCTVCICYJCY-PZMKEKQBSA-N 518375 US11111270, Compound 40 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518375&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 118467932 461604394 C15496 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094490 CN[C@@H](C)C(=O)N[C@H]1CCS[C@H]2CCCC(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C24H34N4O3S/c1-15(25-2)22(29)27-19-13-14-32-21-12-6-11-20(28(21)24(19)31)23(30)26-18-10-5-8-16-7-3-4-9-17(16)18/h3-4,7,9,15,18-21,25H,5-6,8,10-14H2,1-2H3,(H,26,30)(H,27,29)/t15-,18+,19-,20?,21-/m0/s1 FWUVYMSKIZICRV-ADURKJLDSA-N 518376 US11111270, Compound 41 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518376&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 90201642 461604395 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094492 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC3(CC=CC3)C(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C27H36N4O4/c1-17(28-2)24(32)30-21-12-15-35-22-16-27(13-5-6-14-27)23(31(22)26(21)34)25(33)29-20-11-7-9-18-8-3-4-10-19(18)20/h3-6,8,10,17,20-23,28H,7,9,11-16H2,1-2H3,(H,29,33)(H,30,32)/t17-,20+,21-,22-,23?/m0/s1 RSJCHSVTXILJJN-CFLMPHEOSA-N 518377 US11111270, Compound 42 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518377&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071592 461604396 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094495 CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CC3(CCCC3)C(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C27H38N4O4/c1-17(28-2)24(32)30-21-12-15-35-22-16-27(13-5-6-14-27)23(31(22)26(21)34)25(33)29-20-11-7-9-18-8-3-4-10-19(18)20/h3-4,8,10,17,20-23,28H,5-7,9,11-16H2,1-2H3,(H,29,33)(H,30,32)/t17-,20+,21-,22-,23?/m0/s1 OXRCNGFIXLNXEZ-CFLMPHEOSA-N 518378 US11111270, Compound 43 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518378&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 76071593 461604397 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094497 CN[C@@H](C)C(=O)N[C@H]1Cc2ccc(O)c(O)c2[C@H]2CC(C)(C)C(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C30H38N4O5/c1-16(31-4)27(37)33-21-14-18-12-13-23(35)25(36)24(18)22-15-30(2,3)26(34(22)29(21)39)28(38)32-20-11-7-9-17-8-5-6-10-19(17)20/h5-6,8,10,12-13,16,20-22,26,31,35-36H,7,9,11,14-15H2,1-4H3,(H,32,38)(H,33,37)/t16-,20+,21-,22+,26?/m0/s1 OTQFBRPMPBAKHR-GIFDSYCTSA-N 518379 US11111270, Compound 44 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518379&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 118467937 461604398 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094500 CN[C@@H](C)C(=O)N[C@H]1Cc2ccc(O)cc2[C@H]2CC(C)(C)C(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C30H38N4O4/c1-17(31-4)27(36)33-24-14-19-12-13-20(35)15-22(19)25-16-30(2,3)26(34(25)29(24)38)28(37)32-23-11-7-9-18-8-5-6-10-21(18)23/h5-6,8,10,12-13,15,17,23-26,31,35H,7,9,11,14,16H2,1-4H3,(H,32,37)(H,33,36)/t17-,23+,24-,25+,26?/m0/s1 WWSXHSXXXOEQKI-UQFYKGKHSA-N 518381 US11111270, Compound 45 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518381&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 118467925 461604400 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094502 CN[C@@H](C)C(=O)N[C@H]1CC(=O)N[C@H]2CC(C)(C)C(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C25H35N5O4/c1-14(26-4)22(32)28-18-12-20(31)29-19-13-25(2,3)21(30(19)24(18)34)23(33)27-17-11-7-9-15-8-5-6-10-16(15)17/h5-6,8,10,14,17-19,21,26H,7,9,11-13H2,1-4H3,(H,27,33)(H,28,32)(H,29,31)/t14-,17+,18-,19+,21?/m0/s1 DWFJMDXUFGOBCU-OZWJTPLTSA-N 391851 US10300074, Compd 46::US11111270, Compound 46 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=391851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=391851&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 118467917 404960207 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 1094505 CN[C@@H](C)C(=O)N[C@H]1Cc2cccc(O)c2[C@H]2CC(C)(C)C(N2C1=O)C(=O)N[C@@H]1CCCc2ccccc12 InChI=1S/C30H38N4O4/c1-17(31-4)27(36)33-22-15-19-11-8-14-24(35)25(19)23-16-30(2,3)26(34(23)29(22)38)28(37)32-21-13-7-10-18-9-5-6-12-20(18)21/h5-6,8-9,11-12,14,17,21-23,26,31,35H,7,10,13,15-16H2,1-4H3,(H,32,37)(H,33,36)/t17-,21+,22-,23+,26?/m0/s1 MCFVXTPYAYIVLS-UZHXMYFXSA-N 518384 US11111270, Compound 47 E3 ubiquitin-protein ligase XIAP [265-330] <25000 US Patent 10.7270/Q2S185NQ aid1805925 US11111270 Cosford, ND; Vamos, MD SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=518384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1121&target=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=518384&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B265-330%5D&column=ki&startPg=0&Increment=50&submit=Search 118467891 461604403 1 YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYL E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14