BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 370227 CNc1nc(cn2c(C)nnc12)-c1cn(C)nc1Cc1ccccc1 InChI=1S/C18H19N7/c1-12-21-22-18-17(19-2)20-16(11-25(12)18)14-10-24(3)23-15(14)9-13-7-5-4-6-8-13/h4-8,10-11H,9H2,1-3H3,(H,19,20) RSTUWYLUVVSQFJ-UHFFFAOYSA-N 209449 US10328074, Example I-1::US11077107, Example I-1::US9266891, I-1 Bromodomain-containing protein 4 [44-168]/Histone H4 61 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209449&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071531 328082495 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370228 CNc1nc(cn2c(C)nnc12)-c1cnn(C)c1Oc1ccccc1 InChI=1S/C17H17N7O/c1-11-21-22-16-15(18-2)20-14(10-24(11)16)13-9-19-23(3)17(13)25-12-7-5-4-6-8-12/h4-10H,1-3H3,(H,18,20) MUDFQCHHOJYXCS-UHFFFAOYSA-N 209450 US10328074, Example I-2::US11077107, Example I-2::US9266891, I-2 Bromodomain-containing protein 4 [44-168]/Histone H4 41 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209450&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071532 328082496 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370229 Cc1nnc2c(C)nc(cn12)-c1cnn(C)c1Oc1ccccc1 InChI=1S/C17H16N6O/c1-11-16-21-20-12(2)23(16)10-15(19-11)14-9-18-22(3)17(14)24-13-7-5-4-6-8-13/h4-10H,1-3H3 IISZWHJYEZSSQM-UHFFFAOYSA-N 209451 US10328074, Example I-3::US11077107, Example I-3::US9266891, I-3 Bromodomain-containing protein 4 [44-168]/Histone H4 41 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209451&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071533 328082497 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370230 CNc1nc(cn2c(C)nnc12)-c1nn(C)c(C)c1Cc1ccccc1 InChI=1S/C19H21N7/c1-12-15(10-14-8-6-5-7-9-14)17(24-25(12)4)16-11-26-13(2)22-23-19(26)18(20-3)21-16/h5-9,11H,10H2,1-4H3,(H,20,21) JAXAHBJRANHVLF-UHFFFAOYSA-N 209452 US10328074, Example I-4::US9266891, I-4 Bromodomain-containing protein 4 [44-168]/Histone H4 18 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209452&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071649 328082498 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370231 CNc1nc(cn2c(C)nnc12)-c1nn(C)c(C)c1Oc1ccccc1 InChI=1S/C18H19N7O/c1-11-16(26-13-8-6-5-7-9-13)15(23-24(11)4)14-10-25-12(2)21-22-18(25)17(19-3)20-14/h5-10H,1-4H3,(H,19,20) IJZDKKQZNSYLGO-UHFFFAOYSA-N 209453 US10328074, Example I-5::US11077107, Example I-5::US9266891, I-5 Bromodomain-containing protein 4 [44-168]/Histone H4 8 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209453&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071650 328082499 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370232 CNc1nc(cn2c(C)nnc12)-c1nc(c(C)n1Cc1ccccc1)-c1ccccc1 InChI=1S/C24H23N7/c1-16-21(19-12-8-5-9-13-19)27-23(30(16)14-18-10-6-4-7-11-18)20-15-31-17(2)28-29-24(31)22(25-3)26-20/h4-13,15H,14H2,1-3H3,(H,25,26) FCQIYPQMTYFWQM-UHFFFAOYSA-N 209457 US10328074, Example II-1::US11077107, Example II-1::US9266891, II-1 Bromodomain-containing protein 4 [44-168]/Histone H4 4 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209457&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071651 328082500 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370233 CNc1nc(cn2c(C)nnc12)-c1nc(C)c(C)n1Cc1ccccc1 InChI=1S/C19H21N7/c1-12-13(2)25(10-15-8-6-5-7-9-15)18(21-12)16-11-26-14(3)23-24-19(26)17(20-4)22-16/h5-9,11H,10H2,1-4H3,(H,20,22) QXTRPBVVUWEMOH-UHFFFAOYSA-N 209458 US10328074, Example II-2::US11077107, Example II-2::US9266891, II-2 Bromodomain-containing protein 4 [44-168]/Histone H4 15 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209458&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071652 328082501 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370234 Cc1nc(-c2cn3c(C)nnc3c(C)n2)n(Cc2ccccc2)c1C InChI=1S/C19H20N6/c1-12-14(3)24(10-16-8-6-5-7-9-16)19(21-12)17-11-25-15(4)22-23-18(25)13(2)20-17/h5-9,11H,10H2,1-4H3 PBHCWSGBMHUVGJ-UHFFFAOYSA-N 209459 US10328074, Example II-3::US11077107, Example II-3::US9266891, II-3 Bromodomain-containing protein 4 [44-168]/Histone H4 31 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209459&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071653 328082502 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370235 CN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccc1 InChI=1S/C26H28N8/c1-18-30-31-26-24(27-20-12-14-32(2)15-13-20)28-22(17-33(18)26)25-29-21-10-6-7-11-23(21)34(25)16-19-8-4-3-5-9-19/h3-11,17,20H,12-16H2,1-2H3,(H,27,28) SJLGONPWSYKHIB-UHFFFAOYSA-N 209460 US10328074, Example III-1::US11077107, Example III-1::US9266891, III-1 Bromodomain-containing protein 4 [44-168]/Histone H4 7 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209460&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071654 328082503 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370236 COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1[C@@H](C)c1ccccc1 InChI=1S/C29H34N8O/c1-20(22-9-5-4-6-10-22)37-26-12-8-7-11-24(26)32-28(37)25-19-36-21(2)33-34-29(36)27(31-25)30-23-13-15-35(16-14-23)17-18-38-3/h4-12,19-20,23H,13-18H2,1-3H3,(H,30,31)/t20-/m0/s1 KIGOYJHUPSVEGZ-FQEVSTJZSA-N 209461 US10328074, Example III-2::US11077107, Example III-2::US9266891, III-2 Bromodomain-containing protein 4 [44-168]/Histone H4 41 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209461&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071770 328082504 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370237 COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1[C@H](C)c1ccccc1 InChI=1S/C29H34N8O/c1-20(22-9-5-4-6-10-22)37-26-12-8-7-11-24(26)32-28(37)25-19-36-21(2)33-34-29(36)27(31-25)30-23-13-15-35(16-14-23)17-18-38-3/h4-12,19-20,23H,13-18H2,1-3H3,(H,30,31)/t20-/m1/s1 KIGOYJHUPSVEGZ-HXUWFJFHSA-N 209462 US10328074, Example III-3::US11077107, Example III-3::US9266891, III-3 Bromodomain-containing protein 4 [44-168]/Histone H4 49 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209462&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071771 328082505 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370238 COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccc1 InChI=1S/C28H32N8O/c1-20-32-33-28-26(29-22-12-14-34(15-13-22)16-17-37-2)30-24(19-35(20)28)27-31-23-10-6-7-11-25(23)36(27)18-21-8-4-3-5-9-21/h3-11,19,22H,12-18H2,1-2H3,(H,29,30) FSVRQKKTQOWUTB-UHFFFAOYSA-N 209463 US10328074, Example III-4::US11077107, Example III-4::US9266891, III-4 Bromodomain-containing protein 4 [44-168]/Histone H4 8 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209463&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071772 328082506 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370239 COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccc(F)cc1 InChI=1S/C28H31FN8O/c1-19-33-34-28-26(30-22-11-13-35(14-12-22)15-16-38-2)31-24(18-36(19)28)27-32-23-5-3-4-6-25(23)37(27)17-20-7-9-21(29)10-8-20/h3-10,18,22H,11-17H2,1-2H3,(H,30,31) TUSWVDDMTVUGBQ-UHFFFAOYSA-N 209464 US10328074, Example III-5::US11077107, Example III-5::US9266891, III-5 Bromodomain-containing protein 4 [44-168]/Histone H4 9 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209464&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071773 328082507 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370240 COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccc(F)c(F)c1 InChI=1S/C28H30F2N8O/c1-18-34-35-28-26(31-20-9-11-36(12-10-20)13-14-39-2)32-24(17-37(18)28)27-33-23-5-3-4-6-25(23)38(27)16-19-7-8-21(29)22(30)15-19/h3-8,15,17,20H,9-14,16H2,1-2H3,(H,31,32) YMNBDQGRLMZZPM-UHFFFAOYSA-N 209465 US10328074, Example III-6::US11077107, Example III-6::US9266891, III-6 Bromodomain-containing protein 4 [44-168]/Histone H4 9 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209465&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071774 328082508 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370241 CNc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccc1 InChI=1S/C21H19N7/c1-14-25-26-21-19(22-2)23-17(13-27(14)21)20-24-16-10-6-7-11-18(16)28(20)12-15-8-4-3-5-9-15/h3-11,13H,12H2,1-2H3,(H,22,23) GPMKACUDCQFCCA-UHFFFAOYSA-N 209466 US10328074, Example III-7::US11077107, Example III-7::US9266891, III-7 Bromodomain-containing protein 4 [44-168]/Histone H4 22 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209466&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071895 328082509 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370242 CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccc1)N1CCN(C)CC1 InChI=1S/C25H28N10/c1-17-30-31-25-23(26-2)28-20(16-34(17)25)24-29-19-14-27-22(33-11-9-32(3)10-12-33)13-21(19)35(24)15-18-7-5-4-6-8-18/h4-8,13-14,16H,9-12,15H2,1-3H3,(H,26,28) UACQAGADNJRGFK-UHFFFAOYSA-N 209467 US10328074, Example III-8::US11077107, Example III-8::US9266891, III-8 Bromodomain-containing protein 4 [44-168]/Histone H4 9 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209467&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071896 328082510 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370243 CN1CCN(CC1)c1cc2n(Cc3ccccc3)c(nc2cn1)-c1cn2c(C)nnc2c(C)n1 InChI=1S/C25H27N9/c1-17-24-30-29-18(2)33(24)16-21(27-17)25-28-20-14-26-23(32-11-9-31(3)10-12-32)13-22(20)34(25)15-19-7-5-4-6-8-19/h4-8,13-14,16H,9-12,15H2,1-3H3 GVSWCHHMYQOERK-UHFFFAOYSA-N 209468 US10328074, Example III-9::US11077107, Example III-9::US9266891, III-9 Bromodomain-containing protein 4 [44-168]/Histone H4 14 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209468&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071897 328082511 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370244 CNc1nc(cn2c(C)nnc12)-c1nc2cccnc2n1Cc1ccccc1 InChI=1S/C20H18N8/c1-13-25-26-20-17(21-2)23-16(12-27(13)20)19-24-15-9-6-10-22-18(15)28(19)11-14-7-4-3-5-8-14/h3-10,12H,11H2,1-2H3,(H,21,23) ACNYFFICYHWMRO-UHFFFAOYSA-N 209469 US10328074, Example III-10::US11077107, Example III-10::US9266891, III-10 Bromodomain-containing protein 4 [44-168]/Histone H4 18 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209469&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071898 328082512 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370245 CNc1nc(cn2c(C)nnc12)-c1nc2cnc(nc2n1Cc1ccccc1)N1CCN(C)CC1 InChI=1S/C24H27N11/c1-16-30-31-23-20(25-2)27-19(15-34(16)23)22-28-18-13-26-24(33-11-9-32(3)10-12-33)29-21(18)35(22)14-17-7-5-4-6-8-17/h4-8,13,15H,9-12,14H2,1-3H3,(H,25,27) BCOBWZAGQAFMQP-UHFFFAOYSA-N 209470 US10328074, Example III-11::US11077107, Example III-11::US9266891, III-11 Bromodomain-containing protein 4 [44-168]/Histone H4 9 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209470&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76071899 328082513 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370246 COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccc1)N1CCOCC1 InChI=1S/C32H39N9O2/c1-23-36-37-32-30(33-25-10-12-38(13-11-25)14-17-42-2)34-28(22-40(23)32)31-35-27-9-8-26(39-15-18-43-19-16-39)20-29(27)41(31)21-24-6-4-3-5-7-24/h3-9,20,22,25H,10-19,21H2,1-2H3,(H,33,34) XXMVJVPJGYCSFZ-UHFFFAOYSA-N 209471 US10328074, Example III-12::US11077107, Example III-12::US9266891, III-12 Bromodomain-containing protein 4 [44-168]/Histone H4 7 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209471&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072012 328082514 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370248 CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccc1)N1CCOCC1 InChI=1S/C25H26N8O/c1-17-29-30-25-23(26-2)27-21(16-32(17)25)24-28-20-9-8-19(31-10-12-34-13-11-31)14-22(20)33(24)15-18-6-4-3-5-7-18/h3-9,14,16H,10-13,15H2,1-2H3,(H,26,27) PXHFZHKBGPQRAX-UHFFFAOYSA-N 209473 US10328074, Example III-14::US11077107, Example III-14::US9266891, III-14 Bromodomain-containing protein 4 [44-168]/Histone H4 10 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209473&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072014 328082516 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370249 COCCN1CCC(CC1)Nc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccc1)C1=NNC(=O)CC1C InChI=1S/C33H38N10O2/c1-21-17-29(44)38-39-30(21)24-9-10-28-26(18-24)36-32(43(28)19-23-7-5-4-6-8-23)27-20-42-22(2)37-40-33(42)31(35-27)34-25-11-13-41(14-12-25)15-16-45-3/h4-10,18,20-21,25H,11-17,19H2,1-3H3,(H,34,35)(H,38,44) NYYNLDHMWIENMY-UHFFFAOYSA-N 209474 US10328074, Example III-15::US11077107, Example III-15::US9266891, III-15 Bromodomain-containing protein 4 [44-168]/Histone H4 3 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209474&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 90162042 328082517 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370250 CNc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccc1)C1=NNC(=O)CC1C InChI=1S/C26H25N9O/c1-15-11-22(36)31-32-23(15)18-9-10-21-19(12-18)29-25(35(21)13-17-7-5-4-6-8-17)20-14-34-16(2)30-33-26(34)24(27-3)28-20/h4-10,12,14-15H,11,13H2,1-3H3,(H,27,28)(H,31,36) DCXAWDGRFZGDMY-UHFFFAOYSA-N 209475 US10328074, Example III-16::US11077107, Example III-16::US9266891, III-16 Bromodomain-containing protein 4 [44-168]/Histone H4 5 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209475&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 90162265 328082518 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370251 CCNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccc1)N1CCN(C)CC1 InChI=1S/C26H30N10/c1-4-27-24-26-32-31-18(2)35(26)17-21(29-24)25-30-20-15-28-23(34-12-10-33(3)11-13-34)14-22(20)36(25)16-19-8-6-5-7-9-19/h5-9,14-15,17H,4,10-13,16H2,1-3H3,(H,27,29) NSHYAULTAMQMBT-UHFFFAOYSA-N 209476 US10328074, Example III-17::US11077107, Example III-17::US9266891, III-17 Bromodomain-containing protein 4 [44-168]/Histone H4 17 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209476&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 90161076 328082519 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370252 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccc1)N1CCN(C)CC1 InChI=1S/C27H32N10/c1-18(2)29-25-27-33-32-19(3)36(27)17-22(30-25)26-31-21-15-28-24(35-12-10-34(4)11-13-35)14-23(21)37(26)16-20-8-6-5-7-9-20/h5-9,14-15,17-18H,10-13,16H2,1-4H3,(H,29,30) NZXJUZMTDGHZSR-UHFFFAOYSA-N 209477 US10328074, Example III-18::US11077107, Example III-18::US9266891, III-18 Bromodomain-containing protein 4 [44-168]/Histone H4 26 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209477&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 90161017 328082520 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370253 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1[C@@H](C)c1ccccc1)N1CCOC[C@@H]1C InChI=1S/C28H33N9O/c1-17(2)30-26-28-34-33-20(5)36(28)15-23(31-26)27-32-22-14-29-25(35-11-12-38-16-18(35)3)13-24(22)37(27)19(4)21-9-7-6-8-10-21/h6-10,13-15,17-19H,11-12,16H2,1-5H3,(H,30,31)/t18-,19-/m0/s1 PPMNCASBGOVBMV-OALUTQOASA-N 209478 US10328074, Example III-19::US11077107, Example III-19::US9266891, III-19 Bromodomain-containing protein 4 [44-168]/Histone H4 38 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209478&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search O2B 6XV3 90161075 328082521 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370254 CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCN(C)CC1 InChI=1S/C24H27N11/c1-16-30-31-24-22(25-2)28-19(15-34(16)24)23-29-18-13-27-21(33-10-8-32(3)9-11-33)12-20(18)35(23)14-17-6-4-5-7-26-17/h4-7,12-13,15H,8-11,14H2,1-3H3,(H,25,28) UOBPZZRNSLHSFO-UHFFFAOYSA-N 209479 US10328074, Example III-20::US11077107, Example III-20::US9266891, III-20 Bromodomain-containing protein 4 [44-168]/Histone H4 13 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209479&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072138 328082522 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370255 CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCN(C)CC1 InChI=1S/C25H28N10/c1-17-30-31-25-23(26-2)28-21(16-34(17)25)24-29-20-8-7-19(33-12-10-32(3)11-13-33)14-22(20)35(24)15-18-6-4-5-9-27-18/h4-9,14,16H,10-13,15H2,1-3H3,(H,26,28) WEGRDNGNIKWFOP-UHFFFAOYSA-N 209480 US10328074, Example III-21::US11077107, Example III-21::US9266891, III-21 Bromodomain-containing protein 4 [44-168]/Histone H4 8 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209480&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072137 328082523 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370256 CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCOCC1 InChI=1S/C23H24N10O/c1-15-29-30-23-21(24-2)27-18(14-32(15)23)22-28-17-12-26-20(31-7-9-34-10-8-31)11-19(17)33(22)13-16-5-3-4-6-25-16/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,27) BFYPTOVDLGDJDC-UHFFFAOYSA-N 209481 US10328074, Example III-22::US11077107, Example III-22::US9266891, III-22 Bromodomain-containing protein 4 [44-168]/Histone H4 3 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209481&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072256 328082524 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370257 CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCOCC1 InChI=1S/C24H25N9O/c1-16-29-30-24-22(25-2)27-20(15-32(16)24)23-28-19-7-6-18(31-9-11-34-12-10-31)13-21(19)33(23)14-17-5-3-4-8-26-17/h3-8,13,15H,9-12,14H2,1-2H3,(H,25,27) VUUYIKCADVQZHC-UHFFFAOYSA-N 209482 US10328074, Example III-23::US11077107, Example III-23::US9266891, III-23 Bromodomain-containing protein 4 [44-168]/Histone H4 3 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209482&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070951 328082525 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370258 Cc1nnc2c(N[C@@H]3CCOC3)nc(cn12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCOCC1 InChI=1S/C26H28N10O2/c1-17-32-33-26-24(29-19-5-9-38-16-19)30-21(15-35(17)26)25-31-20-13-28-23(34-7-10-37-11-8-34)12-22(20)36(25)14-18-4-2-3-6-27-18/h2-4,6,12-13,15,19H,5,7-11,14,16H2,1H3,(H,29,30)/t19-/m1/s1 ZEBAQXYAFDJKJH-LJQANCHMSA-N 209483 US10328074, Example III-24::US11077107, Example III-24::US9266891, III-24 Bromodomain-containing protein 4 [44-168]/Histone H4 20 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209483&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072257 328082526 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370259 CNc1nc(cn2c(C)nnc12)-c1nc2cc(ccc2n1Cc1ccccn1)C1CCOCC1 InChI=1S/C25H26N8O/c1-16-30-31-25-23(26-2)28-21(15-32(16)25)24-29-20-13-18(17-8-11-34-12-9-17)6-7-22(20)33(24)14-19-5-3-4-10-27-19/h3-7,10,13,15,17H,8-9,11-12,14H2,1-2H3,(H,26,28) QHJUZMRVSGPOMP-UHFFFAOYSA-N 209484 US10328074, Example III-25::US11077107, Example III-25::US9266891, III-25 Bromodomain-containing protein 4 [44-168]/Histone H4 11 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209484&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072258 328082527 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370260 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N1CCOCC1 InChI=1S/C26H29N9O/c1-17(2)28-24-26-32-31-18(3)34(26)16-22(29-24)25-30-21-8-7-20(33-10-12-36-13-11-33)14-23(21)35(25)15-19-6-4-5-9-27-19/h4-9,14,16-17H,10-13,15H2,1-3H3,(H,28,29) CJHOZKNBDTVZRM-UHFFFAOYSA-N 209485 US10328074, Example III-26::US11077107, Example III-26::US9266891, III-26 Bromodomain-containing protein 4 [44-168]/Histone H4 5 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209485&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072259 328082528 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370261 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCOCC1 InChI=1S/C25H28N10O/c1-16(2)28-23-25-32-31-17(3)34(25)15-20(29-23)24-30-19-13-27-22(33-8-10-36-11-9-33)12-21(19)35(24)14-18-6-4-5-7-26-18/h4-7,12-13,15-16H,8-11,14H2,1-3H3,(H,28,29) CNWQYJUFUYBRNG-UHFFFAOYSA-N 209486 US10328074, Example III-27::US11077107, Example III-27::US9266891, III-27 Bromodomain-containing protein 4 [44-168]/Histone H4 10 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209486&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072260 328082529 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370262 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccc(F)cn1)N1CCOCC1 InChI=1S/C25H27FN10O/c1-15(2)29-23-25-33-32-16(3)35(25)14-20(30-23)24-31-19-12-28-22(34-6-8-37-9-7-34)10-21(19)36(24)13-18-5-4-17(26)11-27-18/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,29,30) KAYFVHVSQSDACO-UHFFFAOYSA-N 209487 US10328074, Example III-28::US11077107, Example III-28::US9266891, III-28 Bromodomain-containing protein 4 [44-168]/Histone H4 1 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209487&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 73891130 328082530 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370263 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCOC[C@H]1C InChI=1S/C26H30N10O/c1-16(2)29-24-26-33-32-18(4)35(26)14-21(30-24)25-31-20-12-28-23(34-9-10-37-15-17(34)3)11-22(20)36(25)13-19-7-5-6-8-27-19/h5-8,11-12,14,16-17H,9-10,13,15H2,1-4H3,(H,29,30)/t17-/m1/s1 SJMFHBQDKBQDTQ-QGZVFWFLSA-N 209488 US10328074, Example III-29::US11077107, Example III-29::US9266891, III-29 Bromodomain-containing protein 4 [44-168]/Histone H4 9 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209488&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072370 328082531 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370264 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N1CCOC[C@@H]1C InChI=1S/C26H30N10O/c1-16(2)29-24-26-33-32-18(4)35(26)14-21(30-24)25-31-20-12-28-23(34-9-10-37-15-17(34)3)11-22(20)36(25)13-19-7-5-6-8-27-19/h5-8,11-12,14,16-17H,9-10,13,15H2,1-4H3,(H,29,30)/t17-/m0/s1 SJMFHBQDKBQDTQ-KRWDZBQOSA-N 209489 US10328074, Example III-30::US11077107, Example III-30::US9266891, III-30 Bromodomain-containing protein 4 [44-168]/Histone H4 9 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209489&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072371 328082532 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370265 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)N(C)C InChI=1S/C23H26N10/c1-14(2)26-21-23-30-29-15(3)32(23)13-18(27-21)22-28-17-11-25-20(31(4)5)10-19(17)33(22)12-16-8-6-7-9-24-16/h6-11,13-14H,12H2,1-5H3,(H,26,27) ZWXIRPBQXSHODB-UHFFFAOYSA-N 209490 US10328074, Example III-31::US11077107, Example III-31::US9266891, III-31 Bromodomain-containing protein 4 [44-168]/Histone H4 13 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209490&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072373 328082533 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370266 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)N(C)C InChI=1S/C24H27N9/c1-15(2)26-22-24-30-29-16(3)32(24)14-20(27-22)23-28-19-10-9-18(31(4)5)12-21(19)33(23)13-17-8-6-7-11-25-17/h6-12,14-15H,13H2,1-5H3,(H,26,27) WUJOUMVRCGTKNK-UHFFFAOYSA-N 209491 US10328074, Example III-32::US11077107, Example III-32::US9266891, III-32 Bromodomain-containing protein 4 [44-168]/Histone H4 7 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209491&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072372 328082534 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370267 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccccc2n1Cc1ccccn1 InChI=1S/C22H22N8/c1-14(2)24-20-22-28-27-15(3)29(22)13-18(25-20)21-26-17-9-4-5-10-19(17)30(21)12-16-8-6-7-11-23-16/h4-11,13-14H,12H2,1-3H3,(H,24,25) JVFXPRFAZLSBIF-UHFFFAOYSA-N 209492 US10328074, Example III-33::US11077107, Example III-33::US9266891, III-33 Bromodomain-containing protein 4 [44-168]/Histone H4 20 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209492&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072374 328082535 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370268 COc1ccc2nc(-c3cn4c(C)nnc4c(NC(C)C)n3)n(Cc3ccccn3)c2c1 InChI=1S/C23H24N8O/c1-14(2)25-21-23-29-28-15(3)30(23)13-19(26-21)22-27-18-9-8-17(32-4)11-20(18)31(22)12-16-7-5-6-10-24-16/h5-11,13-14H,12H2,1-4H3,(H,25,26) WKNJQMMPCXOMRN-UHFFFAOYSA-N 209493 US10328074, Example III-34::US11077107, Example III-34::US9266891, III-34 Bromodomain-containing protein 4 [44-168]/Histone H4 45 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209493&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070626 328082536 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370269 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(C)cc2n1Cc1ccccn1 InChI=1S/C23H24N8/c1-14(2)25-21-23-29-28-16(4)30(23)13-19(26-21)22-27-18-9-8-15(3)11-20(18)31(22)12-17-7-5-6-10-24-17/h5-11,13-14H,12H2,1-4H3,(H,25,26) CUVAZMTZHFSHFL-UHFFFAOYSA-N 209494 US10328074, Example III-35::US11077107, Example III-35::US9266891, III-35 Bromodomain-containing protein 4 [44-168]/Histone H4 15 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209494&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070627 328082537 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370270 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(C)cc2n1Cc1ccccn1 InChI=1S/C22H23N9/c1-13(2)25-20-22-29-28-15(4)30(22)12-18(26-20)21-27-17-10-24-14(3)9-19(17)31(21)11-16-7-5-6-8-23-16/h5-10,12-13H,11H2,1-4H3,(H,25,26) BYHXJJUONGOTKC-UHFFFAOYSA-N 209495 US10328074, Example III-36::US11077107, Example III-36::US9266891, III-36 Bromodomain-containing protein 4 [44-168]/Histone H4 28 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209495&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070628 328082538 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370271 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnccc2n1Cc1ccccn1 InChI=1S/C21H21N9/c1-13(2)24-19-21-28-27-14(3)29(21)12-17(25-19)20-26-16-10-22-9-7-18(16)30(20)11-15-6-4-5-8-23-15/h4-10,12-13H,11H2,1-3H3,(H,24,25) PTLRUSZADXPAID-UHFFFAOYSA-N 209496 US10328074, Example III-37::US11077107, Example III-37::US9266891, III-37 Bromodomain-containing protein 4 [44-168]/Histone H4 14 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209496&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070629 328082539 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370272 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1cccc(C)n1)N1CCOCC1 InChI=1S/C26H30N10O/c1-16(2)28-24-26-33-32-18(4)35(26)15-21(30-24)25-31-20-13-27-23(34-8-10-37-11-9-34)12-22(20)36(25)14-19-7-5-6-17(3)29-19/h5-7,12-13,15-16H,8-11,14H2,1-4H3,(H,28,30) STCCXFZWQGBXJD-UHFFFAOYSA-N 209497 US10328074, Example III-38::US11077107, Example III-38::US9266891, III-38 Bromodomain-containing protein 4 [44-168]/Histone H4 17 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209497&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070630 328082540 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370273 COc1cc2n(Cc3ccccn3)c(nc2cn1)-c1cn2c(C)nnc2c(NC(C)C)n1 InChI=1S/C22H23N9O/c1-13(2)25-20-22-29-28-14(3)30(22)12-17(26-20)21-27-16-10-24-19(32-4)9-18(16)31(21)11-15-7-5-6-8-23-15/h5-10,12-13H,11H2,1-4H3,(H,25,26) UQEASOOHOYLOSE-UHFFFAOYSA-N 209498 US10328074, Example III-39::US11077107, Example III-39::US9266891, III-39 Bromodomain-containing protein 4 [44-168]/Histone H4 126 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209498&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070631 328082541 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370274 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)C(C)C InChI=1S/C24H27N9/c1-14(2)18-10-21-19(11-26-18)29-23(33(21)12-17-8-6-7-9-25-17)20-13-32-16(5)30-31-24(32)22(28-20)27-15(3)4/h6-11,13-15H,12H2,1-5H3,(H,27,28) LMBQVBQBODBFRL-UHFFFAOYSA-N 209499 US10328074, Example III-40::US11077107, Example III-40::US9266891, III-40 Bromodomain-containing protein 4 [44-168]/Histone H4 18 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209499&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070733 328082542 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370275 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1[C@@H](C)c1ccccn1)N1CCOC[C@@H]1C InChI=1S/C27H32N10O/c1-16(2)30-25-27-34-33-19(5)36(27)14-22(31-25)26-32-21-13-29-24(35-10-11-38-15-17(35)3)12-23(21)37(26)18(4)20-8-6-7-9-28-20/h6-9,12-14,16-18H,10-11,15H2,1-5H3,(H,30,31)/t17-,18-/m0/s1 ICQWKYPGTXWGCR-ROUUACIJSA-N 209500 US10328074, Example III-41::US11077107, Example III-41::US9266891, III-41 Bromodomain-containing protein 4 [44-168]/Histone H4 74 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209500&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070734 328082543 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370276 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1[C@@H](C)c1ccccn1)C(C)C InChI=1S/C25H29N9/c1-14(2)19-11-22-20(12-27-19)30-24(34(22)16(5)18-9-7-8-10-26-18)21-13-33-17(6)31-32-25(33)23(29-21)28-15(3)4/h7-16H,1-6H3,(H,28,29)/t16-/m0/s1 YXEKBZDFBBBFJB-INIZCTEOSA-N 209501 US10328074, Example III-42::US11077107, Example III-42::US9266891, III-42 Bromodomain-containing protein 4 [44-168]/Histone H4 66 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209501&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070735 328082544 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370277 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccccn1)C1CCOCC1 InChI=1S/C26H29N9O/c1-16(2)29-24-26-33-32-17(3)34(26)15-22(30-24)25-31-21-13-28-20(18-7-10-36-11-8-18)12-23(21)35(25)14-19-6-4-5-9-27-19/h4-6,9,12-13,15-16,18H,7-8,10-11,14H2,1-3H3,(H,29,30) RGVADVPFHZUZFO-UHFFFAOYSA-N 209502 US10328074, Example III-43::US11077107, Example III-43::US9266891, III-43 Bromodomain-containing protein 4 [44-168]/Histone H4 34 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209502&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070736 328082545 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370278 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccn1)C1CCOCC1 InChI=1S/C27H30N8O/c1-17(2)29-25-27-33-32-18(3)34(27)16-23(30-25)26-31-22-8-7-20(19-9-12-36-13-10-19)14-24(22)35(26)15-21-6-4-5-11-28-21/h4-8,11,14,16-17,19H,9-10,12-13,15H2,1-3H3,(H,29,30) FRMBPERTEITNRY-UHFFFAOYSA-N 209503 US10328074, Example III-44::US11077107, Example III-44::US9266891, III-44 Bromodomain-containing protein 4 [44-168]/Histone H4 32 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209503&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070737 328082546 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370279 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1[C@@H](C)c1ccccn1)C1CCOCC1 InChI=1S/C28H32N8O/c1-17(2)30-26-28-34-33-19(4)35(28)16-24(31-26)27-32-23-9-8-21(20-10-13-37-14-11-20)15-25(23)36(27)18(3)22-7-5-6-12-29-22/h5-9,12,15-18,20H,10-11,13-14H2,1-4H3,(H,30,31)/t18-/m0/s1 SAFUIPXIPYTSEU-SFHVURJKSA-N 209504 US10328074, Example III-45::US11077107, Example III-45::US9266891, III-45 Bromodomain-containing protein 4 [44-168]/Histone H4 69 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209504&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070842 328082547 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370280 CC(C)Nc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1[C@@H](C)c1ccccn1)C(C)C InChI=1S/C26H30N8/c1-15(2)19-10-11-21-23(13-19)34(17(5)20-9-7-8-12-27-20)25(30-21)22-14-33-18(6)31-32-26(33)24(29-22)28-16(3)4/h7-17H,1-6H3,(H,28,29)/t17-/m0/s1 BOANFFSJBALNEO-KRWDZBQOSA-N 209505 US10328074, Example III-46::US11077107, Example III-46::US9266891, III-46 Bromodomain-containing protein 4 [44-168]/Histone H4 243 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209505&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070843 328082548 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370281 CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1cccnc1)N1CCN(C)CC1 InChI=1S/C24H27N11/c1-16-30-31-24-22(25-2)28-19(15-34(16)24)23-29-18-13-27-21(33-9-7-32(3)8-10-33)11-20(18)35(23)14-17-5-4-6-26-12-17/h4-6,11-13,15H,7-10,14H2,1-3H3,(H,25,28) WIHQCRGWXGPCAU-UHFFFAOYSA-N 209506 US11077107, Example III-47::US9266891, III-47 Bromodomain-containing protein 4 [44-168]/Histone H4 12 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209506&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070844 328082549 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370282 CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1cccnc1)N1CCN(C)CC1 InChI=1S/C25H28N10/c1-17-30-31-25-23(26-2)28-21(16-34(17)25)24-29-20-7-6-19(33-11-9-32(3)10-12-33)13-22(20)35(24)15-18-5-4-8-27-14-18/h4-8,13-14,16H,9-12,15H2,1-3H3,(H,26,28) OMVCEOIEFNQPMM-UHFFFAOYSA-N 209507 US10328074, Example III-48::US11077107, Example III-48::US9266891, III-48 Bromodomain-containing protein 4 [44-168]/Histone H4 8 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209507&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070845 328082550 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370283 CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1cccnc1)N1CCOCC1 InChI=1S/C23H24N10O/c1-15-29-30-23-21(24-2)27-18(14-32(15)23)22-28-17-12-26-20(31-6-8-34-9-7-31)10-19(17)33(22)13-16-4-3-5-25-11-16/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,24,27) HWYPQYNAVWQEKO-UHFFFAOYSA-N 209508 US10328074, Example III-49::US11077107, Example III-49::US9266891, III-49 Bromodomain-containing protein 4 [44-168]/Histone H4 4 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209508&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070846 328082551 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370284 CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1cccnc1)N1CCOCC1 InChI=1S/C24H25N9O/c1-16-29-30-24-22(25-2)27-20(15-32(16)24)23-28-19-6-5-18(31-8-10-34-11-9-31)12-21(19)33(23)14-17-4-3-7-26-13-17/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,25,27) UUCXBSUBBNYHGE-UHFFFAOYSA-N 209509 US10328074, Example III-50::US11077107, Example III-50::US9266891, III-50 Bromodomain-containing protein 4 [44-168]/Histone H4 5 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209509&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070950 328082552 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370285 Cc1nnc2c(N[C@@H]3CCOC3)nc(cn12)-c1nc2cnc(cc2n1Cc1cccnc1)N1CCOCC1 InChI=1S/C26H28N10O2/c1-17-32-33-26-24(29-19-4-8-38-16-19)30-21(15-35(17)26)25-31-20-13-28-23(34-6-9-37-10-7-34)11-22(20)36(25)14-18-3-2-5-27-12-18/h2-3,5,11-13,15,19H,4,6-10,14,16H2,1H3,(H,29,30)/t19-/m1/s1 VSKQFDSORJPDSV-LJQANCHMSA-N 209510 US10328074, Example III-51::US11077107, Example III-51::US9266891, III-51 Bromodomain-containing protein 4 [44-168]/Histone H4 13 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209510&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070952 328082553 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370286 Cc1nnc2c(N[C@@H]3CCOC3)nc(cn12)-c1nc2cnc(C)cc2n1Cc1cccnc1 InChI=1S/C23H23N9O/c1-14-8-20-18(10-25-14)28-22(32(20)11-16-4-3-6-24-9-16)19-12-31-15(2)29-30-23(31)21(27-19)26-17-5-7-33-13-17/h3-4,6,8-10,12,17H,5,7,11,13H2,1-2H3,(H,26,27)/t17-/m1/s1 YTKVHFHJCRSLOJ-QGZVFWFLSA-N 209511 US10328074, Example III-52::US11077107, Example III-52::US9266891, III-52 Bromodomain-containing protein 4 [44-168]/Histone H4 31 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209511&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070953 328082554 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370287 CNc1nc(cn2c(C)nnc12)-c1nc2cnc(cc2n1Cc1ccncc1)N1CCN(C)CC1 InChI=1S/C24H27N11/c1-16-30-31-24-22(25-2)28-19(15-34(16)24)23-29-18-13-27-21(33-10-8-32(3)9-11-33)12-20(18)35(23)14-17-4-6-26-7-5-17/h4-7,12-13,15H,8-11,14H2,1-3H3,(H,25,28) LAXUANUISYQZNT-UHFFFAOYSA-N 209512 US10328074, Example III-53::US11077107, Example III-53::US9266891, III-53 Bromodomain-containing protein 4 [44-168]/Histone H4 12 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209512&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76070954 328082555 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7 370247 CNc1nc(cn2c(C)nnc12)-c1nc2ccc(cc2n1Cc1ccccc1)N1CCN(C)CC1 InChI=1S/C26H29N9/c1-18-30-31-26-24(27-2)28-22(17-34(18)26)25-29-21-10-9-20(33-13-11-32(3)12-14-33)15-23(21)35(25)16-19-7-5-4-6-8-19/h4-10,15,17H,11-14,16H2,1-3H3,(H,27,28) JLUUVUUYIXBDCG-UHFFFAOYSA-N 209472 US10328074, Example III-13::US11077107, Example III-13::US9266891, III-13 Bromodomain-containing protein 4 [44-168]/Histone H4 9 US Patent 10.7270/Q23X85G7 aid1802310 US9266891 Engelhardt, H; Gianni, D; Smethurst, C Boehringer Ingelheim International GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=209472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50003578&target=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=209472&enzyme=Bromodomain-containing+protein+4+%5B44-168%5D%2FHistone+H4&column=ki&startPg=0&Increment=50&submit=Search 76072013 328082515 2 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 2OSS,2YEL,3JVJ,3JVK,3MUK,3MUL,3MXF,3P5O,3SVF,3SVG,3U5J,3U5K,3U5L,3UVW,3UVX,3UVY,3UW9,3ZYU,4A9L,4BJX,4BW1,4BW2,4BW3,4BW4,4C66,4C67,4CFK,4CFL,4CL9,4CLB,4DON,4E96,4F3I,4GPJ,4HBV,4HBX,4HBY,4HXK,4HXL,4HXM,4HXN,4HXO,4HXP,4HXR,4HXS,4IOO,4IOQ,4IOR,4J0R,4J0S,4J3I,4KV1,4LR6,4LRG,4LYI,4LYS,4LYW,4LZS,4MEN,4MEO,4MEP,4MEQ,4MR3,4MR4,4NQM,4NR8,4NUC,4NUD,4NUE,4O70,4O71,4O72,4O74,4O75,4O76,4O77,4O78,4O7A,4O7B,4O7C,4O7E,4O7F,4OGI,4OGJ,4PCE,4PCI,4PS5,4QB3,4QR3,4QR4,4QR5,4QZS,4UIY,4UIZ,4UYD,4WHW,4WIV,4X2I,4XY9,4XYA,4YH3,4YH4,4Z1Q,4Z1S,4ZC9,4ZW1,5A85,5ACY,5AD2,5AD3,5BT4,5CFW,5COI,5CP5,5CPE,5CQT,5CRM,5CRZ,5CS8,5CTL,5CY9,5D0C,5D24,5D25,5D26,5D3H,5D3J,5D3L,5D3N,5D3P,5D3R,5D3S,5D3T,5DLX,5DLZ,5DW2,5DX4,5E0R,5EGU,5EI4,5EIS,5F5Z,5F60,5F61,5F62,5F63,5FBX,5H21,5HCL,5HLS,5HM0,5HQ5,5HQ6,5HQ7,5I80,5I88,5IGK,5KDH,5KHM,5KJ0,5KU3,5LJ1,5LJ2,5LUU,5M39,5M3A,5MKZ,5MLI,5N2M,5NNC,5NND,5NNE,5NNF,5NNG,5O97,5OVB,5OWM,5OWW,5S9P,5S9Q,5S9R,5TI2,5TI3,5TI4,5TI5,5TI6,5TI7,5U28,5U2E,5U2F,5ULA,5UVW,5V67,5VBO,5VBP,5VOM,5VZS,5W55,5WA5,5WMA,5WUU,5XHY,5XI2,5XI3,5XI4,5Y1Y,5Y8C,5Y8W,5Y8Y,5Y8Z,5Y93,5Y94,5YOU,5YOV,5YQX,5Z1R,5Z1S,5Z1T,5Z5T,5Z5U,5Z5V,5Z8G,5Z8R,5Z8Z,5Z90,5Z9C,5Z9K,6AFR,6AJV,6AJW,6AJX,6AJY,6AJZ,6BN7,6BN9,6BNB,6BOY,6C7R,6CD4,6CD5,6CIS,6CIY,6CJ1,6CJ2,6CKR,6CKS,6CZU,6CZV,6DJC,6DL2,6DMJ,6DML,6E4A,6FNX,6FO5,6FSY,6FT3,6FT4,6G0D,6G0E,6G0F,6G0G,6G0H,6G0O,6G0P,6G0Q,6G0R,6G0S,6HDQ,6HOV,6I7X,6I7Y,6IN1,6JI3,6JI4,6JI5,6JJ3,6JJ5,6JJ6,6JJB,6KEC,6KED,6KEE,6KEF,6KEG,6KEH,6KEI,6KEJ,6KEK,6LG4,6LG5,6LG6,6LG7,6LG8,6LG9,6LIH,6LIM,6MAU,6MH1,6MH7,6P05,6PRT,6PS9,6PSB,6Q3Y,6Q3Z,6RWJ,6S25,6S4B,6S6K,6SA2,6SA3,6SAH,6SAJ,6SB8,6SE4,6U0D,6U6K,6U72,6U74,6U8G,6U8M,6ULS,6ULV,6UVJ,6UVM,6UWU,6UWX,6V0U,6V1K,6V1L,6V1U,6VIW,6VIZ,6VUB,6VUC,6VUF,6VUJ,6WGX,6WVX,6WW8,6X7B,6X7C,6X7D,6XUZ,6XV3,6XV7,6XVC,6YIN,6YQN,6YQO,6YQP,6YQZ,6ZCI,7AJN,7AXR,7B1T,7C2Z,7DHS,7EHW,7EHY,7EIG,7EIK,7EIL,7FH2,7JKW,7JKX,7JKY,7K6G,7K6H,7KHH,7KHL,7L9M,7LA9,7LH8,7M16,7MCE,7MCF,7MLQ,7MLR,7MLS,7MR5,7MR6,7MR7,7MR8,7MR9,7MRA,7MRB,7Q3F,7R5B,7R9C,7REK,7REL,7REM,7RJO,7RJP,7RJQ,7RJR,7RMD,7RN2,7RUI,7RXR,7RXS,7RXT,7T3F,7TUQ,7TV0,7UGF,7UTY,7UZN,7V1U,7V2J,7W3D,7WJS,7WKY,7WL4,7WWZ,7X6T,7YL2,7YMG,7YQ9,7ZAQ,7ZE6,7ZEF,7ZFV,8B5B,8B5C,8BDS,8BEB,8DYR,8E17,8E3W,8EAD,8GPZ,8GQ0,8P9F,8P9G,8P9H,8P9I,8P9J,8P9K,8P9L,8PIQ Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG 1EQZ,1F66,1HIO,1HQ3,1KX3,1KX4,1KX5,1M18,1M19,1M1A,1P34,1P3A,1P3B,1P3F,1P3G,1P3I,1P3K,1P3L,1P3M,1P3O,1P3P,1S32,1TZY,1U35,1ZBB,1ZLA,2ARO,2CV5,2F8N,2FJ7,2HUE,2IO5,2NQB,2NZD,2PYO,3A6N,3AFA,3AN2,3AV1,3AV2,3AYW,3AZE,3AZF,3AZG,3AZH,3B6F,3B6G,3C1B,3C1C,3C9K,3KUY,3KWQ,3KXB,3LEL,3LJA,3LZ0,3LZ1,3MGP,3MGQ,3MGR,3MGS,3MNN,3MVD,3NQJ,3NQU,3O62,3R45,3REH,3REI,3REJ,3REK,3REL,3TU4,3UT9,3UTA,3UTB,3W96,3W97,3W98,3W99,3WA9,3WAA,3WKJ,3WTP,3X1S,3X1T,3X1U,3X1V,4H9N,4H9O,4H9P,4H9Q,4H9R,4H9S,4HGA,4J8U,4J8V,4J8W,4J8X,4KGC,4LD9,4PSX,4QLC,4R8P,4WU8,4WU9,4X23,4XUJ,4XZQ,4YM5,4YM6,4YS3,4Z2M,4Z5T,4Z66,4ZBJ,4ZUX,5AV5,5AV6,5AV8,5AV9,5AVB,5AVC,5AY8,5B0Y,5B0Z,5B1L,5B1M,5B24,5B2I,5B2J,5B31,5B32,5B33,5BNV,5BNX,5BO0,5BS7,5BSA,5C3I,5CP6,5CPI,5CPJ,5CPK,5DNM,5DNN,5E5A,5GSE,5GSU,5GT0,5GT3,5GTC,5GXQ,5HQ2,5JA4,5JRG,5KDM,5KGF,5MLU,5NL0,5O9G,5OMX,5ONG,5ONW,5OXV,5OY7,5WCU,5X0X,5X0Y,5X7X,5XF3,5XF4,5XF5,5XF6,5XM0,5XM1,5Y0C,5Y0D,5Z23,5Z30,5Z3L,5Z3O,5Z3U,5Z3V,5ZBX,6A5L,6A5O,6A5P,6A5R,6A5T,6A5U,6BUZ,6C0W,6DZT,6E0C,6E0P,6ESF,6ESG,6ESH,6ESI,6FML,6FQ5,6FQ6,6FQ8,6FTX,6G0L,6HKT,6HTS,6I84,6INQ,6IPU,6IQ4,6IR9,6IRO,6IY2,6IY3,6J4W,6J4X,6J4Y,6J4Z,6J50,6J51,6J99,6JM9,6JMA,6JOU,6JR0,6JR1,6JXD,6JYL,6K1I,6K1J,6K1K,6K1P,6KE9,6KIU,6KIV,6KIW,6KIX,6KIZ,6KVD,6KW3,6KW4,6KW5,6KXV,6L49,6L4A,6L9H,6L9Z,6LA2,6LA8,6LA9,6LAB,6LE9,6LER,6LTJ,6M3V,6M44,6M4D,6M4G,6M4H,6MUO,6MUP,6NE3,6NJ9,6NN6,6NOG,6NQA,6NZO,6O1D,6O22,6O96,6OM3,6PA7,6PWV,6PWW,6PWX,6PX1,6PX3,6R0C,6R1T,6R1U,6R25,6R8Y,6R8Z,6R90,6R91,6R92,6R93,6R94,6RNY,6RYR,6RYU,6S01,6SE0,6SE6,6SEE,6SEF,6SEG,6T79,6T7A,6T7B,6T7C,6T7D,6T90,6T93,6T9L,6TDA,6TEM,6UGM,6UH5,6UPK,6UPL,6USJ,6UXW,6V2K,6V92,6VEN,6VYP,6VZ4,6W5I,6W5M,6W5N,6WKR,6WZ5,6WZ9,6X0N,6X59,6X5A,6XJD,6Y5D,6Y5E,6YN1,6YOV,6Z6P,6ZHX,6ZHY,7A08,7AT8,7BWD,7BXT,7BY0,7C0M,7CCQ,7CCR,7CIZ,7CJ0,7COW,7CRO,7CRP,7CRQ,7CRR,7D1Z,7D20,7DBH,7DBP,7E8D,7E8I,7EA5,7EA8,7EG6,7EGP,7ENN,7JO9,7JOA,7JZV,7K5X,7K5Y,7K60,7K61,7K63,7K6P,7K6Q,7KBD,7KBE,7KBF,7KTQ,7LYA,7LYB,7LYC,7M1X,7MBM,7MBN,7NKX,7NKY,7NL0,7OH9,7OHA,7OHB,7OHC,7OTQ,7PET,7PEU,7PEV,7PEW,7PEX,7PEY,7PEZ,7PF0,7PF2,7PF3,7PF4,7PF5,7PF6,7PFA,7PFC,7PFD,7PFE,7PFF,7PFT,7PFU,7PFV,7PFW,7PFX,7PGV,7PGW,7PH5,7PH6,7PII,7R5R,7SCY,7SCZ,7SSA,7SWY,7TAN,7TN2,7U0G,7U0I,7U0J,7U46,7U47,7U4D,7U50,7U51,7U52,7U53,7UD5,7UNC,7UND,7UNK,7UV9,7UX9,7V1M,7V6Q,7V90,7V96,7V9C,7V9J,7V9K,7V9S,7VA4,7VBM,7VCQ,7VDT,7VDV,7VVU,7VVZ,7VZ4,7W9V,7WBV,7WBW,7WBX,7X57,7X58,7XAY,7XCR,7XCT,7XD0,7XD1,7XFC,7XFH,7XFI,7XFL,7XFM,7XFN,7XNP,7XPX,7XSE,7XSX,7XSZ,7XT7,7XTD,7XTI,7XVL,7XVM,7XX5,7XX6,7XX7,7XZX,7XZY,7XZZ,7Y00,7Y5U,7Y5V,7Y5W,7Y60,7Y61,7Y7I,7Y8R,7YI1,7YI4,7YI5,7YOZ,7YQK,7YRD,7YWX,7YYH,7ZI4,7ZS9,7ZSA,7ZSB,8AAG,8ATF,8AV6,8BVW,8BYQ,8BZ1,8CEO,8CWW,8CZE,8DK5,8DU4,8ETT,8ETV,8EU2,8EUE,8EUJ,8F86,8G57,8G86,8G88,8G8B,8G8G,8GPN,8GRM,8GRQ,8H0V,8H0W,8H1T,8HAG,8HAH,8HAI,8HAJ,8HAK,8HAL,8HAM,8HAN,8HE5,8IQF,8IQG,8J6S,8J6T,8OF4,8OO7,8OOA,8OOP,8OOS,8OSJ,8OSK,8OSL,8OTS,8OTT,8PC5,8PC6,8PEO,8PEP,8SIY,8SPS,8SPU Histone H4 H4_HUMAN P62805 A2VCL0 P02304 P02305 Q6DRA9 Q6FGB8 Q6NWP7