BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 374866 CC(C)(O)C[NH+]1Cc2cn(nc2C1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl 213186 US9290517, 14 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 29 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213186&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 124201733 329728726 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374867 Clc1cc2[nH]c(O[C@@H]3CO[C@@H]4[C@@H](CO[C@H]34)OCC=C)nc2nc1-c1ccc(cc1)-c1ccccc1 213187 US9290517, 18 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 6 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213187&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067327 329728727 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374868 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)C#CC1CCNCC1 213188 US9290517, 71 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 10 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213188&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 86684750 329728728 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374869 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1cc[nH]c1=O 213189 US9290517, 73 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213189&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067388 329728729 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374870 CC(CO)(CO)c1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl 213190 US9290517, 79 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213190&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067219 329728730 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374871 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(CCCC(O)=O)cc1 213191 US9290517, 86 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213191&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424618 329728731 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374872 Cc1nnc(o1)-c1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl 213192 US9290517, 87 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213192&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424619 329728732 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374873 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1F)C#N 213193 US9290517, 102 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 5 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213193&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067292 329728733 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374874 CCN(CC)c1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl 213194 US9290517, 105 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 5 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213194&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424631 329728734 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374875 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1=NC(CC1)C(O)=O 213195 US9290517, 125 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 6 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213195&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424639 329728735 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374876 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1Cc2nccn2C1 213196 US9290517, 126 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213196&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067441 329728736 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374877 Cn1c(N)ncc1-c1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl 213197 US9290517, 127 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213197&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424641 329728737 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374878 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1cc(nn1)C(O)(O)C(F)(F)F 213198 US9290517, 128 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213198&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067423 329728738 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374879 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1cnc(=O)[nH]1 213199 US9290517, 129 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213199&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424640 329728739 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374880 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nccc(O)n1 213200 US9290517, 130 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213200&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067439 329728740 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374881 Cc1cc(-c2ccc(cc2)-c2ccc(cc2)-c2nc3nc(O[C@@H]4CO[C@@H]5[C@H](O)CO[C@H]45)[nH]c3cc2Cl)c(=O)[nH]n1 InChI=1S/C29H22ClN5O5/c1-14-10-19(28(37)35-34-14)17-6-2-15(3-7-17)16-4-8-18(9-5-16)24-20(30)11-21-27(32-24)33-29(31-21)40-23-13-39-25-22(36)12-38-26(23)25/h2-11,22-23,25-26,36H,12-13H2,1H3/b16-15-,19-17-,24-18+/t22-,23-,25-,26-/m1/s1 AEVQBBDRFREYSM-CWNOGFBWSA-N 213201 US9290517, 131 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213201&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 124201734 329728741 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374882 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CNCCO1 213202 US9290517, 133 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213202&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73211772 329728742 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374883 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1noc(=O)[nH]1 213203 US9290517, 138 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213203&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 124201735 329728743 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374884 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(Cn2ncnn2)cc1 213204 US9290517, 142 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213204&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424648 329728744 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374885 CC1(COC1)c1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl 213205 US9290517, 145 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 8 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213205&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067295 329728745 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374886 OCc1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl 213206 US9290517, 146 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213206&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424650 329728746 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374887 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(Cn2ccnc2)cc1 213207 US9290517, 147 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213207&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067315 329728747 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374888 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CNC(=O)C1 213208 US9290517, 149 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213208&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424651 329728748 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374889 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1ccc(=O)[nH]1 213209 US9290517, 150 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213209&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067573 329728749 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 374890 CN(C)CCOc1ccc(cc1)-c1ccc(cc1)-c1nc2nc(O[C@@H]3CO[C@@H]4[C@H](O)CO[C@H]34)[nH]c2cc1Cl 213210 US9290517, 151 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2 7.3 US Patent 10.7270/Q2C24V7Q aid1802392 US9290517 Apgar, JM; Arasappan, A; Biftu, T; Chen, P; Feng, D; Guidry, E; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; McCracken, T; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213210&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118424652 329728750 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453969 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nccc(O)n1 260428 US9527839, 6 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 7 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260428&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90059452 350085112 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453970 CC(CO)(CO)c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@H]3CO[C@H](CO)[C@@H](O)C3)[nH]c2cc1Cl 260429 US9527839, 7 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 6 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260429&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90059466 350085113 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453971 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CNCCO1 260430 US9527839, 8 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 12 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260430&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73335447 350085114 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453972 Nc1nc(=N)n([nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@H]3CO[C@H](CO)[C@@H](O)C3)[nH]c2cc1Cl 260431 US9527839, 16 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 7 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260431&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73335450 350085115 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453973 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C1CCNCC1 260432 US9527839, 18 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 14 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260432&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118231488 350085116 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453974 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CCNC1=O 260433 US9527839, 19 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 15 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260433&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73335551 350085117 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453975 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1cncn1 260434 US9527839, 21 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 9 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260434&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73335552 350085118 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453976 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nnn[nH]1 InChI=1S/C26H21ClN6O4/c27-20-11-22-21(28-26(29-22)37-18-9-23(35)24(12-34)36-13-18)10-19(20)16-5-1-14(2-6-16)15-3-7-17(8-4-15)25-30-32-33-31-25/h1-8,10-11,18,23-24,34-35H,9,12-13H2/t18-,23+,24-/m1/s1 YMCJXGJTMOBZJD-PUZWTLIVSA-N 260435 US9527839, 23 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 18 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260435&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118231491 350085119 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453977 CC(C)(O)Cc1cnn(c1)-c1ccc(cc1)-c1ccc(cc1)-c1cc2nc(O[C@H]3CO[C@H](CO)[C@@H](O)C3)[nH]c2cc1Cl 260436 US9527839, 24 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 18 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260436&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73335553 350085120 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453978 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nccc(O)n1 260439 US9527839, 35 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260439&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73335348 350085123 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453979 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CNCCO1 260440 US9527839, 36 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260440&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73335446 350085124 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453980 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1ncco1 260441 US9527839, 38 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260441&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118231492 350085125 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453981 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nccs1 260442 US9527839, 39 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 13 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260442&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73335448 350085126 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453982 Nc1nc(=N)n([nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1c(F)cc2[nH]c(O[C@H]3CO[C@H](CO)[C@@H](O)C3)nc2c1F 260443 US9527839, 40 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 5 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260443&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118231493 350085127 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453983 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)S(=O)(=O)C1CCNCC1 260444 US9527839, 42 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 8 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260444&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118231496 350085128 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453984 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)C1CCNC1=O 260445 US9527839, 43 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260445&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118231495 350085129 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453985 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(CCCC(O)=O)cc1 260446 US9527839, 44 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 11 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260446&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118231497 350085130 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453986 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-n1cncn1 260447 US9527839, 45 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260447&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73335449 350085131 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453987 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nnc(O)o1 260448 US9527839, 47 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 7 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260448&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118231499 350085132 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453988 CNC(=O)c1ccc(cc1)-c1ccc(cc1)-c1c(F)cc2[nH]c(O[C@H]3CO[C@H](CO)[C@@H](O)C3)nc2c1F 260449 US9527839, 48 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260449&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73053659 350085133 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453989 OC[C@H]1OC[C@@H](C[C@@H]1O)Oc1nc2c(F)c(c(F)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1)-c1nnn[nH]1 InChI=1S/C26H20F2N6O4/c27-18-10-19-24(30-26(29-19)38-17-9-20(36)21(11-35)37-12-17)23(28)22(18)15-5-1-13(2-6-15)14-3-7-16(8-4-14)25-31-33-34-32-25/h1-8,10,17,20-21,35-36H,9,11-12H2/t17-,20+,21-/m1/s1 GKNPHAIPBBCMOO-JRGCBEDISA-N 260450 US9527839, 49 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 9 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260450&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118231500 350085134 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 453990 CC(C)(O)Cc1cnn(c1)-c1ccc(cc1)-c1ccc(cc1)-c1c(F)cc2[nH]c(O[C@H]3CO[C@H](CO)[C@@H](O)C3)nc2c1F 260451 US9527839, 50 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 7 7.3 25.00 C US Patent 10.7270/Q2N58K9B aid1803679 US9527839 Apgar, JM; Biftu, T; Chen, P; Feng, D; Hicks, JD; Kekec, A; Leavitt, KJ; Li, B; Sebhat, I; Qian, X; Wei, L; Wilkening, RR; Wu, Z Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=260451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=260451&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90059426 350085135 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50518262 OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)CCC1 InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23) FHQXLWCFSUSXBF-UHFFFAOYSA-N 237920 US9394285, 1 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 6.8 ChEMBL 10.1021/acs.jmedchem.6b00866 10.7270/Q2PZ5BRC 27490827 Cameron, KO; Kung, DW; Kalgutkar, AS; Kurumbail, RG; Miller, R; Salatto, CT; Ward, J; Withka, JM; Bhattacharya, SK; Boehm, M; Borzilleri, KA; Brown, JA; Calabrese, M; Caspers, NL; Cokorinos, E; Conn, EL; Dowling, MS; Edmonds, DJ; Eng, H; Fernando, DP; Frisbie, R; Hepworth, D; Landro, J; Mao, Y; Rajamohan, F; Reyes, AR; Rose, CR; Ryder, T; Shavnya, A; Smith, AC; Tu, M; Wolford, AC; Xiao, J Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237920&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 6VT 5KQ5 71748255 340131342 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50521688 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2nc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccc(cc1F)C#N 213193 US9290517, 102 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 5.0 ChEMBL 10.1016/j.bmcl.2016.09.065 10.7270/Q25M67PH 27727125 Cameron, KO; Kurumbail, RG Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=213193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=213193&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 90067292 329728733 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50521695 O[C@@H]1CO[C@@H]2[C@@H](CO[C@H]12)Oc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1c(O)cccc1O InChI=1S/C25H21ClN2O6/c26-15-9-17-16(27-25(28-17)34-21-11-33-23-20(31)10-32-24(21)23)8-14(15)12-4-6-13(7-5-12)22-18(29)2-1-3-19(22)30/h1-9,20-21,23-24,29-31H,10-11H2,(H,27,28)/t20-,21-,23-,24-/m1/s1 MMOYHXCYJWHUCI-LUGTWXOSSA-N 50195534 CHEMBL3957286 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 27 ChEMBL 10.1016/j.bmcl.2016.09.065 10.7270/Q25M67PH 27727125 Cameron, KO; Kurumbail, RG Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195534&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118640135 375977210 CHEMBL3957286 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064037 Clc1ccc(cc1)C(=C1\C(=O)N(Cc2ccccc2)c2ccccc12)\c1ccccc1 InChI=1S/C28H20ClNO/c29-23-17-15-22(16-18-23)26(21-11-5-2-6-12-21)27-24-13-7-8-14-25(24)30(28(27)31)19-20-9-3-1-4-10-20/h1-18H,19H2/b27-26+ WJCHQNHAZNJMNW-CYYJNZCTSA-N 50434258 CHEMBL2386124 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1000 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434258&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73356509 175446575 CHEMBL2386124 ZINC96270358 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064038 CC(C)NC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccc(Cl)cc3)c3ccccc23)c1 InChI=1S/C32H27ClN2O2/c1-21(2)34-31(36)25-12-8-9-22(19-25)20-35-28-14-7-6-13-27(28)30(32(35)37)29(23-10-4-3-5-11-23)24-15-17-26(33)18-16-24/h3-19,21H,20H2,1-2H3,(H,34,36)/b30-29+ HDCCOOJWZMEJMT-QVIHXGFCSA-N 50434259 CHEMBL2386123 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4500 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434259&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51033890 175446576 CHEMBL2386123 ZINC96270359 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064039 OC(=O)c1ccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccc(Cl)cc3)c3ccccc23)nc1 InChI=1S/C28H19ClN2O3/c29-21-13-10-19(11-14-21)25(18-6-2-1-3-7-18)26-23-8-4-5-9-24(23)31(27(26)32)17-22-15-12-20(16-30-22)28(33)34/h1-16H,17H2,(H,33,34)/b26-25+ SHHPEHILSHYFOI-OCEACIFDSA-N 50434260 CHEMBL2386122 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 9200 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434260&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51034106 175446577 CHEMBL2386122 ZINC96270360 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064040 CC(C)C(=C1/C(=O)N(Cc2cccc(c2)C(O)=O)c2ccccc12)\c1ccccc1 InChI=1S/C26H23NO3/c1-17(2)23(19-10-4-3-5-11-19)24-21-13-6-7-14-22(21)27(25(24)28)16-18-9-8-12-20(15-18)26(29)30/h3-15,17H,16H2,1-2H3,(H,29,30)/b24-23+ OXQOQYXJZXMGOQ-WCWDXBQESA-N 50434261 CHEMBL2386121 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 >10000 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434261&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 73353437 175446578 CHEMBL2386121 ZINC96270361 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064041 OC(=O)c1cccc(CN2C(=O)\C(=C(/C3CCCCC3)c3ccc(Cl)cc3)c3ccccc23)c1 InChI=1S/C29H26ClNO3/c30-23-15-13-21(14-16-23)26(20-8-2-1-3-9-20)27-24-11-4-5-12-25(24)31(28(27)32)18-19-7-6-10-22(17-19)29(33)34/h4-7,10-17,20H,1-3,8-9,18H2,(H,33,34)/b27-26+ IEHKYPCVCDXRRX-CYYJNZCTSA-N 50434262 CHEMBL2386120 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4600 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434262&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51034879 175446579 CHEMBL2386120 ZINC96270362 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064042 CC(C)C(=C1/C(=O)N(Cc2cccc(c2)C(O)=O)c2ccccc12)\c1ccc(Cl)cc1 InChI=1S/C26H22ClNO3/c1-16(2)23(18-10-12-20(27)13-11-18)24-21-8-3-4-9-22(21)28(25(24)29)15-17-6-5-7-19(14-17)26(30)31/h3-14,16H,15H2,1-2H3,(H,30,31)/b24-23+ JYNUCGGUAIPMJH-WCWDXBQESA-N 50434263 CHEMBL2386119 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 9900 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434263&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51034776 175446580 CHEMBL2386119 ZINC96270363 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064043 OC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3cccnc3)c3ccccc23)c1 InChI=1S/C28H20N2O3/c31-27-26(25(20-9-2-1-3-10-20)22-12-7-15-29-17-22)23-13-4-5-14-24(23)30(27)18-19-8-6-11-21(16-19)28(32)33/h1-17H,18H2,(H,32,33)/b26-25+ IHLPWSQJQIQBPW-OCEACIFDSA-N 50434264 CHEMBL2386118 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3200 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434264&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51034209 175446581 CHEMBL2386118 ZINC96270364 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064044 OC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccccc3OC(F)(F)F)c3ccccc23)c1 InChI=1S/C30H20F3NO4/c31-30(32,33)38-25-16-7-5-14-23(25)26(20-10-2-1-3-11-20)27-22-13-4-6-15-24(22)34(28(27)35)18-19-9-8-12-21(17-19)29(36)37/h1-17H,18H2,(H,36,37)/b27-26+ ICINAXKSSWVRFJ-CYYJNZCTSA-N 50434265 CHEMBL2386117 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 7400 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434265&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51035101 175446582 CHEMBL2386117 ZINC96270365 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064045 CC(C)c1ccc(cc1)C(=C1\C(=O)N(Cc2cccc(c2)C(O)=O)c2ccccc12)\c1ccccc1 InChI=1S/C32H27NO3/c1-21(2)23-15-17-25(18-16-23)29(24-10-4-3-5-11-24)30-27-13-6-7-14-28(27)33(31(30)34)20-22-9-8-12-26(19-22)32(35)36/h3-19,21H,20H2,1-2H3,(H,35,36)/b30-29+ VDWZXUABVAUQGO-QVIHXGFCSA-N 50434266 CHEMBL2386116 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4000 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434266&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51034436 175446583 CHEMBL2386116 ZINC96270366 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064046 OC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccccc3Cl)c3ccccc23)c1 InChI=1S/C29H20ClNO3/c30-24-15-6-4-13-22(24)26(20-10-2-1-3-11-20)27-23-14-5-7-16-25(23)31(28(27)32)18-19-9-8-12-21(17-19)29(33)34/h1-17H,18H2,(H,33,34)/b27-26+ QAAVACKXEXJBKY-CYYJNZCTSA-N 50434267 CHEMBL2386115 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1800 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434267&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51035679 175446584 CHEMBL2386115 ZINC96270367 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064047 OC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccc(Cl)cc3)c3ccccc23)c1 InChI=1S/C29H20ClNO3/c30-23-15-13-21(14-16-23)26(20-8-2-1-3-9-20)27-24-11-4-5-12-25(24)31(28(27)32)18-19-7-6-10-22(17-19)29(33)34/h1-17H,18H2,(H,33,34)/b27-26+ BPBOVHROVFJFAH-CYYJNZCTSA-N 50434268 CHEMBL2386114 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1200 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434268&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51033997 175446585 CHEMBL2386114 ZINC96270368 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064048 OC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccc(F)c(Cl)c3)c3ccccc23)c1 InChI=1S/C29H19ClFNO3/c30-23-16-20(13-14-24(23)31)26(19-8-2-1-3-9-19)27-22-11-4-5-12-25(22)32(28(27)33)17-18-7-6-10-21(15-18)29(34)35/h1-16H,17H2,(H,34,35)/b27-26+ OZLCCDXVQZDQDV-CYYJNZCTSA-N 50434269 CHEMBL2386113 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 5900 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434269&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 51033438 175446586 CHEMBL2386113 ZINC96270369 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064049 OC(=O)c1cccc(CN2C(=O)\C(=C\c3ccc(o3)-c3ccc(F)c(Cl)c3)c3ccccc23)c1 InChI=1S/C27H17ClFNO4/c28-22-13-17(8-10-23(22)29)25-11-9-19(34-25)14-21-20-6-1-2-7-24(20)30(26(21)31)15-16-4-3-5-18(12-16)27(32)33/h1-14H,15H2,(H,32,33)/b21-14+ IRGLJOMTFFOSAQ-KGENOOAVSA-N 50434270 CHEMBL2385952 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4800 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434270&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 71655487 175446587 CHEMBL2385952 ZINC96270370 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064050 OC(=O)c1cccc(CN2C(=O)\C(=C\c3ccc(o3)-c3cccc(c3)[N+]([O-])=O)c3ccccc23)c1 InChI=1S/C27H18N2O6/c30-26-23(15-21-11-12-25(35-21)18-6-4-8-20(14-18)29(33)34)22-9-1-2-10-24(22)28(26)16-17-5-3-7-19(13-17)27(31)32/h1-15H,16H2,(H,31,32)/b23-15+ XGMAFLGVQDFESM-HZHRSRAPSA-N 50434271 CHEMBL2385951 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3200 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434271&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 71655427 175446588 CHEMBL2385951 ZINC96270371 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51064051 Cc1cc(-c2ccc(\C=C3/S\C(NC3=O)=N/c3ccc(Cl)c(c3)C(O)=O)o2)c(cc1C)[N+]([O-])=O InChI=1S/C23H16ClN3O6S/c1-11-7-16(18(27(31)32)8-12(11)2)19-6-4-14(33-19)10-20-21(28)26-23(34-20)25-13-3-5-17(24)15(9-13)22(29)30/h3-10H,1-2H3,(H,29,30)(H,25,26,28)/b20-10- RTHRCOIONCZINZ-JMIUGGIZSA-N 50434272 CHEMBL1242297 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 300 ChEMBL 10.1021/ml400028q 10.7270/Q2Z039HW 24900695 Yu, LF; Li, YY; Su, MB; Zhang, M; Zhang, W; Zhang, LN; Pang, T; Zhang, RT; Liu, B; Li, JY; Li, J; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50434272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50434272&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 5753734 175446589 CHEMBL1242297 ZINC13549354 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50547307 CC1(C)C(=O)N([C@H]2CCc3c2cccc3O)c2nc(Nc3ccccc3)ncc12 InChI=1S/C23H22N4O2/c1-23(2)17-13-24-22(25-14-7-4-3-5-8-14)26-20(17)27(21(23)29)18-12-11-16-15(18)9-6-10-19(16)28/h3-10,13,18,28H,11-12H2,1-2H3,(H,24,25,26)/t18-/m0/s1 XLFNLJYGUOLEJS-SFHVURJKSA-N 50208911 CHEMBL3884319 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 206 ChEMBL 10.1016/j.bmcl.2016.08.068 10.7270/Q2N018JC 27816515 Katz, JD; Haidle, A; Childers, KK; Zabierek, AA; Jewell, JP; Hou, Y; Altman, MD; Szewczak, A; Chen, D; Harsch, A; Hayashi, M; Warren, L; Hutton, M; Nuthall, H; Su, HP; Munshi, S; Stanton, MG; Davies, IW; Munoz, B; Northrup, A Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50208911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50208911&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 69036886 375982220 CHEMBL3884319 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767830 OC(=O)c1ccccc1Sc1nc2cc(Cl)c(Cl)cc2[nH]1 InChI=1S/C14H8Cl2N2O2S/c15-8-5-10-11(6-9(8)16)18-14(17-10)21-12-4-2-1-3-7(12)13(19)20/h1-6H,(H,17,18)(H,19,20) PISUJWDTMDZQPJ-UHFFFAOYSA-N 50246123 CHEMBL4066431 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 8100 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246123&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 137632068 401960399 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767831 OC(=O)Cc1cccc(Sc2nc3cc(Cl)c(Cl)cc3[nH]2)c1 InChI=1S/C15H10Cl2N2O2S/c16-10-6-12-13(7-11(10)17)19-15(18-12)22-9-3-1-2-8(4-9)5-14(20)21/h1-4,6-7H,5H2,(H,18,19)(H,20,21) KUGMLOJDIGSBHS-UHFFFAOYSA-N 50246124 CHEMBL4097407 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2900 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246124&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 137660607 401960400 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767832 OC(=O)c1csc(Sc2nc3cc(Cl)c(Cl)cc3[nH]2)n1 InChI=1S/C11H5Cl2N3O2S2/c12-4-1-6-7(2-5(4)13)15-10(14-6)20-11-16-8(3-19-11)9(17)18/h1-3H,(H,14,15)(H,17,18) AHWQSCCVKPSRCD-UHFFFAOYSA-N 50246125 CHEMBL4078587 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2600 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246125&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 137648941 401960401 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767833 OC(=O)CCSc1nc2cc(Cl)c(Cl)cc2[nH]1 InChI=1S/C10H8Cl2N2O2S/c11-5-3-7-8(4-6(5)12)14-10(13-7)17-2-1-9(15)16/h3-4H,1-2H2,(H,13,14)(H,15,16) OOGOMWDSALGLBW-UHFFFAOYSA-N 50246126 CHEMBL4077813 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 8500 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246126&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 84616853 401960402 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767834 OC(=O)CCc1nc2cc(Cl)c(cc2[nH]1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C22H17ClN2O2/c23-18-13-20-19(24-21(25-20)10-11-22(26)27)12-17(18)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-9,12-13H,10-11H2,(H,24,25)(H,26,27) SFFILNZADNOIGW-UHFFFAOYSA-N 50246133 CHEMBL4064094 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 6000 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246133&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 58387208 401960403 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767835 OC(=O)CCc1nc2cc(Cl)c(cc2[nH]1)-c1ccccc1 InChI=1S/C16H13ClN2O2/c17-12-9-14-13(18-15(19-14)6-7-16(20)21)8-11(12)10-4-2-1-3-5-10/h1-5,8-9H,6-7H2,(H,18,19)(H,20,21) BSERUQHPTMLPAX-UHFFFAOYSA-N 50246141 CHEMBL4093406 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 8000 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246141&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 58387200 401960404 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767836 OC(=O)c1cccc(Sc2nc3cc(Cl)c(Cl)cc3[nH]2)c1 InChI=1S/C14H8Cl2N2O2S/c15-9-5-11-12(6-10(9)16)18-14(17-11)21-8-3-1-2-7(4-8)13(19)20/h1-6H,(H,17,18)(H,19,20) LQPMUWJSMPISMF-UHFFFAOYSA-N 50246142 CHEMBL4071905 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 7400 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246142&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 137638417 401960405 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767837 OC(=O)CSc1nc2cc(C#Cc3ccccc3)c(Cl)cc2[nH]1 InChI=1S/C17H11ClN2O2S/c18-13-9-15-14(19-17(20-15)23-10-16(21)22)8-12(13)7-6-11-4-2-1-3-5-11/h1-5,8-9H,10H2,(H,19,20)(H,21,22) CEJANWVTUAVULS-UHFFFAOYSA-N 50246143 CHEMBL4071467 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 200 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246143&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 46190897 401960406 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767838 OC(=O)c1cccc(Sc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)c1 InChI=1S/C26H17ClN2O2S/c27-22-15-24-23(28-26(29-24)32-20-8-4-7-19(13-20)25(30)31)14-21(22)18-11-9-17(10-12-18)16-5-2-1-3-6-16/h1-15H,(H,28,29)(H,30,31) CIDMKCITJFLYDG-UHFFFAOYSA-N 50246144 CHEMBL4066650 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 800 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246144&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 59267769 401960407 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767839 OC(=O)c1cccc(Sc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2O)c1 InChI=1S/C26H17ClN2O3S/c27-21-14-23-22(28-26(29-23)33-18-5-3-4-17(12-18)25(31)32)13-20(21)16-10-8-15(9-11-16)19-6-1-2-7-24(19)30/h1-14,30H,(H,28,29)(H,31,32) DLJLBDQLJZDDOH-UHFFFAOYSA-N 50246153 CHEMBL4071158 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 29 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246153&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 137640104 401960408 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767840 OC(=O)c1cccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)c1 InChI=1S/C26H17ClN2O3/c27-22-15-24-23(28-26(29-24)32-20-8-4-7-19(13-20)25(30)31)14-21(22)18-11-9-17(10-12-18)16-5-2-1-3-6-16/h1-15H,(H,28,29)(H,30,31) ZZCUNYPTWYCIMM-UHFFFAOYSA-N 50246154 CHEMBL4091973 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 61 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246154&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 68659463 401960409 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767841 OC(=O)c1cc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)ccc1Cl InChI=1S/C26H16Cl2N2O3/c27-21-11-10-18(12-20(21)25(31)32)33-26-29-23-13-19(22(28)14-24(23)30-26)17-8-6-16(7-9-17)15-4-2-1-3-5-15/h1-14H,(H,29,30)(H,31,32) RABSPZBGTXMANZ-UHFFFAOYSA-N 50246155 CHEMBL4078549 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 32 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246155&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 137649820 401960410 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767842 Cc1ccc(Oc2nc3cc(C#Cc4ccccc4)c(Cl)cc3[nH]2)cc1C(O)=O InChI=1S/C23H15ClN2O3/c1-14-7-10-17(12-18(14)22(27)28)29-23-25-20-11-16(19(24)13-21(20)26-23)9-8-15-5-3-2-4-6-15/h2-7,10-13H,1H3,(H,25,26)(H,27,28) PDRSUSNUEHCSFJ-UHFFFAOYSA-N 50246156 CHEMBL4104303 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 7.0 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246156&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 59267750 401960411 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767843 OC(=O)c1cc(Oc2nc3cc(C#Cc4ccccc4)c(Cl)cc3[nH]2)ccc1Cl InChI=1S/C22H12Cl2N2O3/c23-17-9-8-15(11-16(17)21(27)28)29-22-25-19-10-14(18(24)12-20(19)26-22)7-6-13-4-2-1-3-5-13/h1-5,8-12H,(H,25,26)(H,27,28) IRBIGNTWCNZADA-UHFFFAOYSA-N 50246157 CHEMBL4071175 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 15 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246157&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 137640245 401960412 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767844 Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2O)cc1C(O)=O InChI=1S/C27H19ClN2O4/c1-15-6-11-18(12-20(15)26(32)33)34-27-29-23-13-21(22(28)14-24(23)30-27)17-9-7-16(8-10-17)19-4-2-3-5-25(19)31/h2-14,31H,1H3,(H,29,30)(H,32,33) GYUXUICMHBXIKL-UHFFFAOYSA-N 50246158 CHEMBL3393128 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3.0 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246158&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 118053829 401960413 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767845 Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc3n(C)ccc3c2)cc1C(O)=O InChI=1S/C24H18ClN3O3/c1-13-3-5-16(10-17(13)23(29)30)31-24-26-20-11-18(19(25)12-21(20)27-24)14-4-6-22-15(9-14)7-8-28(22)2/h3-12H,1-2H3,(H,26,27)(H,29,30) FHWSAZXFPUMKFL-UHFFFAOYSA-N 50195475 CHEMBL3393127 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2.0 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50195475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50195475&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 992 5ISO,4CFE 45256693 375977203 CHEMBL3393127 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767849 OC(=O)CSc1nc2cc(Cl)c(Cl)cc2[nH]1 InChI=1S/C9H6Cl2N2O2S/c10-4-1-6-7(2-5(4)11)13-9(12-6)16-3-8(14)15/h1-2H,3H2,(H,12,13)(H,14,15) MDHUGAQJEKDLAN-UHFFFAOYSA-N 50246159 CHEMBL4090039 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4000 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246159&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 225100 401960414 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767850 OC(=O)CCc1nc2cc(Cl)c(Cl)cc2[nH]1 InChI=1S/C10H8Cl2N2O2/c11-5-3-7-8(4-6(5)12)14-9(13-7)1-2-10(15)16/h3-4H,1-2H2,(H,13,14)(H,15,16) LJPFVFTWPCXJNK-UHFFFAOYSA-N 50246160 CHEMBL4061943 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 36000 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246160&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 13042082 401960415 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767851 OC(=O)CSc1nc2cc(c(Cl)cc2[nH]1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C21H15ClN2O2S/c22-17-11-19-18(23-21(24-19)27-12-20(25)26)10-16(17)15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-11H,12H2,(H,23,24)(H,25,26) SQYZFDKEIMKUDV-UHFFFAOYSA-N 50246161 CHEMBL4088692 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 150 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246161&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 46190896 401960416 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767854 Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O InChI=1S/C27H19ClN2O3/c1-16-7-12-20(13-21(16)26(31)32)33-27-29-24-14-22(23(28)15-25(24)30-27)19-10-8-18(9-11-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,29,30)(H,31,32) FIKQZQDYGXAUHC-UHFFFAOYSA-N 50246120 CHEMBL4082745 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 8.0 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246120&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 45256689 401960398 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50767855 Cc1ccc(Oc2nc3cc(c(Cl)cc3[nH]2)-c2ccc(cc2)-c2ccn[nH]2)cc1C(O)=O InChI=1S/C24H17ClN4O3/c1-13-2-7-16(10-17(13)23(30)31)32-24-27-21-11-18(19(25)12-22(21)28-24)14-3-5-15(6-4-14)20-8-9-26-29-20/h2-12H,1H3,(H,26,29)(H,27,28)(H,30,31) DYHZGFJZLBGMJY-UHFFFAOYSA-N 50246171 CHEMBL4066628 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 11 ChEMBL 10.1021/acs.jmedchem.7b01344 10.7270/Q2V69N0Q 29035567 Lan, P; Romero, FA; Wodka, D; Kassick, AJ; Dang, Q; Gibson, T; Cashion, D; Zhou, G; Chen, Y; Zhang, X; Zhang, A; Li, Y; Trujillo, ME; Shao, Q; Wu, M; Xu, S; He, H; MacKenna, D; Staunton, J; Chapman, KT; Weber, A; Sebhat, IK; Makara, GM Metabasis Therapeutics Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246171&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 70903174 401960417 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51118972 Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12 InChI=1S/C20H12N2O3S/c21-9-14-18(24)17-15(10-26-20(17)22-19(14)25)12-7-5-11(6-8-12)13-3-1-2-4-16(13)23/h1-8,10,23H,(H2,22,24,25) CTESJDQKVOEUOY-UHFFFAOYSA-N 50242401 4-hydroxy-3-(2'-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile::A-769662::CHEMBL512504 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 390 ChEMBL 10.1021/acs.jmedchem.8b00180 10.7270/Q2DJ5J62 29620890 Young, RJ; Leeson, PD GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242401&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search C1V 5EZV,4CFF,4ZHX 54708532 104099049 CHEMBL512504 ZINC19862631 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51105811 CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](OC(=O)CC(O)=O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C57H94O26/c1-24(2)10-9-14-57(8,83-51-45(73)41(69)39(67)30(79-51)23-75-49-46(74)43(71)47(29(22-60)78-49)81-35(64)19-34(62)63)25-11-16-56(7)36(25)26(61)18-32-54(5)15-13-33(53(3,4)31(54)12-17-55(32,56)6)80-52-48(42(70)38(66)28(21-59)77-52)82-50-44(72)40(68)37(65)27(20-58)76-50/h10,25-33,36-52,58-61,65-74H,9,11-23H2,1-8H3,(H,62,63)/t25-,26+,27+,28+,29+,30+,31-,32+,33-,36-,37+,38+,39+,40-,41-,42-,43+,44+,45+,46+,47+,48+,49+,50-,51-,52-,54-,55+,56+,57-/m0/s1 XENTZWWGCWIEHN-HLJDGUNLSA-N 50450903 CHEMBL4206229 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 ChEMBL 10.1021/acs.jnatprod.6b00789 10.7270/Q2NV9MV6 28345906 Qiu, S; Yang, WZ; Yao, CL; Shi, XJ; Li, JY; Lou, Y; Duan, YN; Wu, WY; Guo, DA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50450903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50450903&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 132576324 433920245 C03400 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51105812 CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](OC(=O)CC(O)=O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C51H84O21/c1-23(2)10-9-14-51(8,72-45-40(64)37(61)35(59)26(20-52)66-45)24-11-16-50(7)34(24)25(55)18-30-48(5)15-13-31(47(3,4)29(48)12-17-49(30,50)6)69-46-43(38(62)36(60)27(21-53)67-46)71-44-41(65)39(63)42(28(22-54)68-44)70-33(58)19-32(56)57/h10,24-31,34-46,52-55,59-65H,9,11-22H2,1-8H3,(H,56,57)/t24-,25+,26+,27+,28+,29-,30+,31-,34-,35+,36+,37-,38-,39+,40+,41+,42+,43+,44-,45-,46-,48-,49+,50+,51-/m0/s1 VMPUMLROAZFJLO-OLAZPVKVSA-N 50450904 CHEMBL4207697 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 ChEMBL 10.1021/acs.jnatprod.6b00789 10.7270/Q2NV9MV6 28345906 Qiu, S; Yang, WZ; Yao, CL; Shi, XJ; Li, JY; Lou, Y; Duan, YN; Wu, WY; Guo, DA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50450904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50450904&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 132576326 433920246 C03400 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51105813 CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2OC[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](OC(=O)CC(O)=O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C56H92O25/c1-24(2)10-9-14-56(8,81-50-44(71)40(67)39(66)30(77-50)23-74-48-43(70)37(64)27(60)22-73-48)25-11-16-55(7)36(25)26(59)18-32-53(5)15-13-33(52(3,4)31(53)12-17-54(32,55)6)78-51-47(41(68)38(65)28(20-57)75-51)80-49-45(72)42(69)46(29(21-58)76-49)79-35(63)19-34(61)62/h10,25-33,36-51,57-60,64-72H,9,11-23H2,1-8H3,(H,61,62)/t25-,26+,27-,28+,29+,30+,31-,32+,33-,36-,37-,38+,39+,40-,41-,42+,43+,44+,45+,46+,47+,48-,49-,50-,51-,53-,54+,55+,56-/m0/s1 YWMMUFIKXYPKRA-ODYFUNJHSA-N 50450905 CHEMBL4202821 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 ChEMBL 10.1021/acs.jnatprod.6b00789 10.7270/Q2NV9MV6 28345906 Qiu, S; Yang, WZ; Yao, CL; Shi, XJ; Li, JY; Lou, Y; Duan, YN; Wu, WY; Guo, DA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50450905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50450905&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 132576328 433920247 C01656 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51105814 CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@@H](CO)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](COC(=O)CC(O)=O)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C56H92O25/c1-24(2)10-9-14-56(8,81-50-46(72)42(68)40(66)30(78-50)23-74-48-44(70)38(64)28(21-58)75-48)25-11-16-55(7)36(25)26(59)18-32-53(5)15-13-33(52(3,4)31(53)12-17-54(32,55)6)79-51-47(43(69)37(63)27(20-57)76-51)80-49-45(71)41(67)39(65)29(77-49)22-73-35(62)19-34(60)61/h10,25-33,36-51,57-59,63-72H,9,11-23H2,1-8H3,(H,60,61)/t25-,26+,27+,28-,29+,30+,31-,32+,33-,36-,37+,38-,39+,40+,41-,42-,43-,44+,45+,46+,47+,48+,49-,50-,51-,53-,54+,55+,56-/m0/s1 UOFHLCPZXZURFL-GPDZXBECSA-N 50450906 CHEMBL4215013 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 ChEMBL 10.1021/acs.jnatprod.6b00789 10.7270/Q2NV9MV6 28345906 Qiu, S; Yang, WZ; Yao, CL; Shi, XJ; Li, JY; Lou, Y; Duan, YN; Wu, WY; Guo, DA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50450906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50450906&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 101835368 433920248 C03645 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51105815 CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](COC(=O)CC(O)=O)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C51H84O21/c1-23(2)10-9-14-51(8,72-45-42(65)38(61)35(58)26(20-52)67-45)24-11-16-50(7)34(24)25(54)18-30-48(5)15-13-31(47(3,4)29(48)12-17-49(30,50)6)70-46-43(40(63)36(59)27(21-53)68-46)71-44-41(64)39(62)37(60)28(69-44)22-66-33(57)19-32(55)56/h10,24-31,34-46,52-54,58-65H,9,11-22H2,1-8H3,(H,55,56)/t24-,25+,26+,27+,28+,29-,30+,31-,34-,35+,36+,37+,38-,39-,40-,41+,42+,43+,44-,45-,46-,48-,49+,50+,51-/m0/s1 OSXWNRAKZUNVDR-QHEGXUBCSA-N 50450907 CHEMBL4209166 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 ChEMBL 10.1021/acs.jnatprod.6b00789 10.7270/Q2NV9MV6 28345906 Qiu, S; Yang, WZ; Yao, CL; Shi, XJ; Li, JY; Lou, Y; Duan, YN; Wu, WY; Guo, DA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50450907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50450907&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 14162967 433920249 C03400 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51105816 CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2OC[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-69-45-41(65)34(58)26(57)21-68-45)24-11-16-52(7)33(24)25(56)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)36(60)28(20-55)71-48)74-46-42(66)38(62)35(59)27(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3/t24-,25+,26-,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-,46-,47-,48-,50-,51+,52+,53-/m0/s1 NODILNFGTFIURN-GZPRDHCNSA-N 50450908 CHEBI:77152::Ginsenoside Rb2 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 ChEMBL 10.1021/acs.jnatprod.6b00789 10.7270/Q2NV9MV6 28345906 Qiu, S; Yang, WZ; Yao, CL; Shi, XJ; Li, JY; Lou, Y; Duan, YN; Wu, WY; Guo, DA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50450908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50450908&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 6917976 433920250 C03400 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51105817 CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C48H82O18/c1-22(2)10-9-14-48(8,66-42-39(60)36(57)33(54)26(20-50)62-42)23-11-16-47(7)31(23)24(52)18-29-45(5)15-13-30(44(3,4)28(45)12-17-46(29,47)6)64-43-40(37(58)34(55)27(21-51)63-43)65-41-38(59)35(56)32(53)25(19-49)61-41/h10,23-43,49-60H,9,11-21H2,1-8H3/t23-,24+,25+,26+,27+,28-,29+,30-,31-,32+,33+,34+,35-,36-,37-,38+,39+,40+,41-,42-,43-,45-,46+,47+,48-/m0/s1 RLDVZILFNVRJTL-IWFVLDDISA-N 50317539 CHEMBL473659::Ginsenoside Rd::ginsenoside-Rd 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 ChEMBL 10.1021/acs.jnatprod.6b00789 10.7270/Q2NV9MV6 28345906 Qiu, S; Yang, WZ; Yao, CL; Shi, XJ; Li, JY; Lou, Y; Duan, YN; Wu, WY; Guo, DA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317539&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 11679800 104151900 67988 CHEMBL473659 C03400 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51105818 CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](COC(=O)CC(O)=O)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C57H94O26/c1-24(2)10-9-14-57(8,83-51-47(74)43(70)40(67)30(80-51)23-76-49-45(72)41(68)37(64)27(20-58)77-49)25-11-16-56(7)36(25)26(60)18-32-54(5)15-13-33(53(3,4)31(54)12-17-55(32,56)6)81-52-48(44(71)38(65)28(21-59)78-52)82-50-46(73)42(69)39(66)29(79-50)22-75-35(63)19-34(61)62/h10,25-33,36-52,58-60,64-74H,9,11-23H2,1-8H3,(H,61,62)/t25-,26+,27+,28+,29+,30+,31-,32+,33-,36-,37+,38+,39+,40+,41-,42-,43-,44-,45+,46+,47+,48+,49+,50-,51-,52-,54-,55+,56+,57-/m0/s1 NTYAVUNEPXGZQJ-KXJMYDKTSA-N 50450909 CHEMBL4203353 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 ChEMBL 10.1021/acs.jnatprod.6b00789 10.7270/Q2NV9MV6 28345906 Qiu, S; Yang, WZ; Yao, CL; Shi, XJ; Li, JY; Lou, Y; Duan, YN; Wu, WY; Guo, DA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50450909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50450909&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 101835367 433920251 C03400 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51105819 CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C InChI=1S/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46+,47-,48-,49-,51-,52+,53+,54-/m0/s1 GZYPWOGIYAIIPV-JBDTYSNRSA-N 50317541 CHEMBL501515::Ginsenoside Rb1::ginsenoside-Rb1 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 17 ChEMBL 10.1021/acs.jnatprod.6b00789 10.7270/Q2NV9MV6 28345906 Qiu, S; Yang, WZ; Yao, CL; Shi, XJ; Li, JY; Lou, Y; Duan, YN; Wu, WY; Guo, DA Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50317541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50317541&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 9898279 104151902 67989 CHEMBL501515 C03400 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51129142 OC(=O)c1c[nH]c2cc(F)c(-c3ccc(cc3)[C@@H]3CCCCO3)c(F)c12 InChI=1S/C20H17F2NO3/c21-14-9-15-18(13(10-23-15)20(24)25)19(22)17(14)12-6-4-11(5-7-12)16-3-1-2-8-26-16/h4-7,9-10,16,23H,1-3,8H2,(H,24,25)/t16-/m0/s1 JQJNGAWEMYQJIQ-INIZCTEOSA-N 50244667 CHEMBL4105032 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 6.0 ChEMBL 10.1021/acs.jmedchem.8b00807 10.7270/Q2Q242WT 30036059 Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50244667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50244667&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 121396404 386403209 CHEMBL4105032 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51129153 COc1nc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(O)=O)N(C)C InChI=1S/C17H16ClN3O3/c1-21(2)15-5-4-9(16(20-15)24-3)10-6-11-12(17(22)23)8-19-14(11)7-13(10)18/h4-8,19H,1-3H3,(H,22,23) MJHBRTGGZYSCHJ-UHFFFAOYSA-N 238079 US9394285, 173 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 27 ChEMBL 10.1021/acs.jmedchem.8b00807 10.7270/Q2Q242WT 30036059 Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238079&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 75O 5T5T 71767991 340131496 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51129154 O[C@@H]1[C@@H](O)[C@H](OC(=O)c2c[nH]c3cc(Cl)c(cc23)-c2ccc(cc2)C2(O)CCC2)O[C@@H]([C@H]1O)C(O)=O InChI=1S/C25H24ClNO9/c26-16-9-17-14(8-13(16)11-2-4-12(5-3-11)25(34)6-1-7-25)15(10-27-17)23(33)36-24-20(30)18(28)19(29)21(35-24)22(31)32/h2-5,8-10,18-21,24,27-30,34H,1,6-7H2,(H,31,32)/t18-,19-,20+,21-,24-/m0/s1 LTLTUJCGZGVBTO-DCIKREJASA-N 50463100 CHEMBL4249790 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 275 ChEMBL 10.1021/acs.jmedchem.8b00807 10.7270/Q2Q242WT 30036059 Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463100&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search HTV 6E4T 121396411 433930365 C03033 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51129155 O[C@@H]1[C@@H](O)[C@H](OC(=O)c2c[nH]c3cc(F)c(c(F)c23)-c2ccc(cc2)[C@@H]2CCCCO2)O[C@@H]([C@H]1O)C(O)=O InChI=1S/C26H25F2NO9/c27-14-9-15-18(19(28)17(14)12-6-4-11(5-7-12)16-3-1-2-8-36-16)13(10-29-15)25(35)38-26-22(32)20(30)21(31)23(37-26)24(33)34/h4-7,9-10,16,20-23,26,29-32H,1-3,8H2,(H,33,34)/t16-,20-,21-,22+,23-,26-/m0/s1 GZCJKJJWOUAGMR-WBTGXFMPSA-N 50463099 CHEMBL4246000 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 332 ChEMBL 10.1021/acs.jmedchem.8b00807 10.7270/Q2Q242WT 30036059 Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463099&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search HUG 6E4W 121396405 433930364 C03033 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51129175 OC(=O)c1c[nH]c2cc(Cl)c(cc12)-c1ccc(cc1)C1(O)CCC1 InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23) FHQXLWCFSUSXBF-UHFFFAOYSA-N 237920 US9394285, 1 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 11 ChEMBL 10.1021/acs.jmedchem.8b00807 10.7270/Q2Q242WT 30036059 Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237920&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 6VT 5KQ5 71748255 340131342 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 51129176 COc1nc(ccc1-c1cc2c(c[nH]c2cc1Cl)C(=O)O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C(O)=O)N(C)C InChI=1S/C23H24ClN3O9/c1-27(2)15-5-4-9(20(26-15)34-3)10-6-11-12(8-25-14(11)7-13(10)24)22(33)36-23-18(30)16(28)17(29)19(35-23)21(31)32/h4-8,16-19,23,25,28-30H,1-3H3,(H,31,32)/t16-,17-,18+,19-,23-/m0/s1 YJKYSCKYOBZSRV-ZFXLNCEJSA-N 50463101 CHEMBL4250253 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 353 ChEMBL 10.1021/acs.jmedchem.8b00807 10.7270/Q2Q242WT 30036059 Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Pfizer Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50463101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50463101&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search HU7 6E4U 121396412 433930366 C03033 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473313 C[C@H](CC[C@@H](O)C(C)(C)O)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C30H52O4/c1-18(9-13-24(32)27(4,5)34)19-15-16-28(6)22-12-10-20-21(11-14-23(31)26(20,2)3)30(22,8)25(33)17-29(19,28)7/h10,18-19,21-25,31-34H,9,11-17H2,1-8H3/t18-,19-,21-,22+,23+,24-,25-,28+,29-,30+/m1/s1 JLYBBRAAICDTIS-AYEHCKLZSA-N 50537682 Mogrol 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3000 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537682&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 14525327 442139245 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473316 CNCCC[C@@H](C)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C28H49NO2/c1-18(9-8-16-29-7)19-14-15-26(4)22-12-10-20-21(11-13-23(30)25(20,2)3)28(22,6)24(31)17-27(19,26)5/h10,18-19,21-24,29-31H,8-9,11-17H2,1-7H3/t18-,19-,21-,22+,23+,24-,26+,27-,28+/m1/s1 MZYLCQHXATYZAN-LPINDTCESA-N 50537683 CHEMBL4635995 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 7400 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537683&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156013907 442139246 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473317 CCNCCC[C@@H](C)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C29H51NO2/c1-8-30-17-9-10-19(2)20-15-16-27(5)23-13-11-21-22(12-14-24(31)26(21,3)4)29(23,7)25(32)18-28(20,27)6/h11,19-20,22-25,30-32H,8-10,12-18H2,1-7H3/t19-,20-,22-,23+,24+,25-,27+,28-,29+/m1/s1 MKDHSQJEBPLWKW-FKWDFZFLSA-N 50537684 CHEMBL4640795 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 5000 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537684&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156015939 442139247 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473318 CCCNCCC[C@@H](C)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C30H53NO2/c1-8-17-31-18-9-10-20(2)21-15-16-28(5)24-13-11-22-23(12-14-25(32)27(22,3)4)30(24,7)26(33)19-29(21,28)6/h11,20-21,23-26,31-33H,8-10,12-19H2,1-7H3/t20-,21-,23-,24+,25+,26-,28+,29-,30+/m1/s1 XGVVPJLQQFNFTE-WSZKGZBVSA-N 50537685 CHEMBL4637165 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 150 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537685&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156011147 442139248 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473321 CC(C)NCCC[C@@H](C)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C30H53NO2/c1-19(2)31-17-9-10-20(3)21-15-16-28(6)24-13-11-22-23(12-14-25(32)27(22,4)5)30(24,8)26(33)18-29(21,28)7/h11,19-21,23-26,31-33H,9-10,12-18H2,1-8H3/t20-,21-,23-,24+,25+,26-,28+,29-,30+/m1/s1 ZUJIGOQKZLKSKM-WSZKGZBVSA-N 50537686 CHEMBL4637006 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 140 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537686&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156011464 442139249 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473322 C[C@H](CCCNC(C)(C)C)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C31H55NO2/c1-20(11-10-18-32-27(2,3)4)21-16-17-29(7)24-14-12-22-23(13-15-25(33)28(22,5)6)31(24,9)26(34)19-30(21,29)8/h12,20-21,23-26,32-34H,10-11,13-19H2,1-9H3/t20-,21-,23-,24+,25+,26-,29+,30-,31+/m1/s1 DTYMUTMYVUGDAB-ISCVFUHISA-N 50537687 CHEMBL4643614 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1400 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537687&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156018552 442139250 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473324 C[C@H](CCCNC1CC1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C30H51NO2/c1-19(8-7-17-31-20-9-10-20)21-15-16-28(4)24-13-11-22-23(12-14-25(32)27(22,2)3)30(24,6)26(33)18-29(21,28)5/h11,19-21,23-26,31-33H,7-10,12-18H2,1-6H3/t19-,21-,23-,24+,25+,26-,28+,29-,30+/m1/s1 PSTKXGXSKRGNQM-BDOYHBRUSA-N 50537688 CHEMBL4636688 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4100 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537688&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156012654 442139251 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473326 C[C@H](CCCNCCCn1ccnc1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C33H55N3O2/c1-23(9-7-16-34-17-8-19-36-20-18-35-22-36)24-14-15-31(4)27-12-10-25-26(11-13-28(37)30(25,2)3)33(27,6)29(38)21-32(24,31)5/h10,18,20,22-24,26-29,34,37-38H,7-9,11-17,19,21H2,1-6H3/t23-,24-,26-,27+,28+,29-,31+,32-,33+/m1/s1 LENXTOOUMVYVFH-GVOOPAHWSA-N 50537689 CHEMBL4648636 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 3500 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537689&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156021781 442139252 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473328 C[C@H](CCCNCCN1CCNCC1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C33H59N3O2/c1-23(8-7-15-34-16-19-36-20-17-35-18-21-36)24-13-14-31(4)27-11-9-25-26(10-12-28(37)30(25,2)3)33(27,6)29(38)22-32(24,31)5/h9,23-24,26-29,34-35,37-38H,7-8,10-22H2,1-6H3/t23-,24-,26-,27+,28+,29-,31+,32-,33+/m1/s1 ICMYMFSWZXUDFV-GVOOPAHWSA-N 50537690 CHEMBL4639889 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 500 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537690&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156014828 442139253 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473329 C[C@H](CCCNCCCO)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C30H53NO3/c1-20(9-7-16-31-17-8-18-32)21-14-15-28(4)24-12-10-22-23(11-13-25(33)27(22,2)3)30(24,6)26(34)19-29(21,28)5/h10,20-21,23-26,31-34H,7-9,11-19H2,1-6H3/t20-,21-,23-,24+,25+,26-,28+,29-,30+/m1/s1 OALVYUVMFPBDIQ-WSZKGZBVSA-N 50537691 CHEMBL4634166 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1400 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537691&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156011054 442139254 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473332 COc1ccc(NCCC[C@@H](C)[C@H]2CC[C@@]3(C)[C@@H]4CC=C5[C@@H](CC[C@H](O)C5(C)C)[C@]4(C)[C@H](O)C[C@]23C)cc1 InChI=1S/C34H53NO3/c1-22(9-8-20-35-23-10-12-24(38-7)13-11-23)25-18-19-32(4)28-16-14-26-27(15-17-29(36)31(26,2)3)34(28,6)30(37)21-33(25,32)5/h10-14,22,25,27-30,35-37H,8-9,15-21H2,1-7H3/t22-,25-,27-,28+,29+,30-,32+,33-,34+/m1/s1 IPBUSBAJTAYAMZ-PNYMIMLSSA-N 50537692 CHEMBL4644881 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 4700 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537692&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156018973 442139255 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473333 C[C@H](CCCNCc1ccccc1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C34H53NO2/c1-23(11-10-20-35-22-24-12-8-7-9-13-24)25-18-19-32(4)28-16-14-26-27(15-17-29(36)31(26,2)3)34(28,6)30(37)21-33(25,32)5/h7-9,12-14,23,25,27-30,35-37H,10-11,15-22H2,1-6H3/t23-,25-,27-,28+,29+,30-,32+,33-,34+/m1/s1 JAMPNBVMBIYBGJ-JFAMYKFUSA-N 50537693 CHEMBL4648110 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1500 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537693&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156020604 442139256 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473334 C[C@H](CCCN[C@@H](C)c1ccccc1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C35H55NO2/c1-23(12-11-21-36-24(2)25-13-9-8-10-14-25)26-19-20-33(5)29-17-15-27-28(16-18-30(37)32(27,3)4)35(29,7)31(38)22-34(26,33)6/h8-10,13-15,23-24,26,28-31,36-38H,11-12,16-22H2,1-7H3/t23-,24+,26-,28-,29+,30+,31-,33+,34-,35+/m1/s1 KBZIXQMCFUPDIW-SAYMFLDTSA-N 50537694 CHEMBL4638899 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1700 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537694&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156013180 442139257 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473336 C[C@H](CCCNCc1ccc(F)cc1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C34H52FNO2/c1-22(8-7-19-36-21-23-9-11-24(35)12-10-23)25-17-18-32(4)28-15-13-26-27(14-16-29(37)31(26,2)3)34(28,6)30(38)20-33(25,32)5/h9-13,22,25,27-30,36-38H,7-8,14-21H2,1-6H3/t22-,25-,27-,28+,29+,30-,32+,33-,34+/m1/s1 LKDMDCZDNCHFMI-PNYMIMLSSA-N 50537695 CHEMBL4641632 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 700 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537695&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156017359 442139258 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473338 C[C@H](CCCNCc1ccc(Cl)cc1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C34H52ClNO2/c1-22(8-7-19-36-21-23-9-11-24(35)12-10-23)25-17-18-32(4)28-15-13-26-27(14-16-29(37)31(26,2)3)34(28,6)30(38)20-33(25,32)5/h9-13,22,25,27-30,36-38H,7-8,14-21H2,1-6H3/t22-,25-,27-,28+,29+,30-,32+,33-,34+/m1/s1 XHHSMRJZFZDRFI-PNYMIMLSSA-N 50537696 CHEMBL4639939 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 600 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537696&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156014986 442139259 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473340 COc1ccc(CNCCC[C@@H](C)[C@H]2CC[C@@]3(C)[C@@H]4CC=C5[C@@H](CC[C@H](O)C5(C)C)[C@]4(C)[C@H](O)C[C@]23C)cc1OC InChI=1S/C36H57NO4/c1-23(10-9-19-37-22-24-11-14-28(40-7)29(20-24)41-8)25-17-18-34(4)30-15-12-26-27(13-16-31(38)33(26,2)3)36(30,6)32(39)21-35(25,34)5/h11-12,14,20,23,25,27,30-32,37-39H,9-10,13,15-19,21-22H2,1-8H3/t23-,25-,27-,30+,31+,32-,34+,35-,36+/m1/s1 HZLHPUONNFSGKZ-NREHWEFGSA-N 50537697 CHEMBL4648563 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 200 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537697&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156020754 442139260 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473342 C[C@H](CCCNCCc1ccccc1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C35H55NO2/c1-24(11-10-21-36-22-19-25-12-8-7-9-13-25)26-18-20-33(4)29-16-14-27-28(15-17-30(37)32(27,2)3)35(29,6)31(38)23-34(26,33)5/h7-9,12-14,24,26,28-31,36-38H,10-11,15-23H2,1-6H3/t24-,26-,28-,29+,30+,31-,33+,34-,35+/m1/s1 RZRTYNDYDYBYTE-DTNZVHPBSA-N 50537698 CHEMBL4641375 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 2000 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537698&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156016383 442139261 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473343 C[C@H](CCCNCCc1ccc(cc1)[N+]([O-])=O)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C35H54N2O4/c1-23(8-7-20-36-21-18-24-9-11-25(12-10-24)37(40)41)26-17-19-33(4)29-15-13-27-28(14-16-30(38)32(27,2)3)35(29,6)31(39)22-34(26,33)5/h9-13,23,26,28-31,36,38-39H,7-8,14-22H2,1-6H3/t23-,26-,28-,29+,30+,31-,33+,34-,35+/m1/s1 ZIDFQCKXMBCNFC-SKDPQLHHSA-N 50537699 CHEMBL4644411 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1700 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537699&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156018930 442139262 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473344 COc1ccc(CCNCCC[C@@H](C)[C@H]2CC[C@@]3(C)[C@@H]4CC=C5[C@@H](CC[C@H](O)C5(C)C)[C@]4(C)[C@H](O)C[C@]23C)cc1OC InChI=1S/C37H59NO4/c1-24(10-9-20-38-21-18-25-11-14-29(41-7)30(22-25)42-8)26-17-19-35(4)31-15-12-27-28(13-16-32(39)34(27,2)3)37(31,6)33(40)23-36(26,35)5/h11-12,14,22,24,26,28,31-33,38-40H,9-10,13,15-21,23H2,1-8H3/t24-,26-,28-,31+,32+,33-,35+,36-,37+/m1/s1 UMEJHYQSYSJECC-WLDXMYKRSA-N 50537700 CHEMBL4640680 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 500 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537700&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156015211 442139263 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473348 C[C@H](CCCNCc1ccccn1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C33H52N2O2/c1-22(10-9-18-34-21-23-11-7-8-19-35-23)24-16-17-31(4)27-14-12-25-26(13-15-28(36)30(25,2)3)33(27,6)29(37)20-32(24,31)5/h7-8,11-12,19,22,24,26-29,34,36-37H,9-10,13-18,20-21H2,1-6H3/t22-,24-,26-,27+,28+,29-,31+,32-,33+/m1/s1 XKKWYKBUGVUDQA-OXQNSESWSA-N 50537701 CHEMBL4646560 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1600 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537701&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156019649 442139264 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473350 C[C@H](CCCNCc1cccnc1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C33H52N2O2/c1-22(9-7-17-34-20-23-10-8-18-35-21-23)24-15-16-31(4)27-13-11-25-26(12-14-28(36)30(25,2)3)33(27,6)29(37)19-32(24,31)5/h8,10-11,18,21-22,24,26-29,34,36-37H,7,9,12-17,19-20H2,1-6H3/t22-,24-,26-,27+,28+,29-,31+,32-,33+/m1/s1 JOBNHTCITVIPCJ-OXQNSESWSA-N 50537702 CHEMBL4643591 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 700 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537702&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156018428 442139265 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473351 C[C@H](CCCNCc1ccncc1)[C@H]1CC[C@@]2(C)[C@@H]3CC=C4[C@@H](CC[C@H](O)C4(C)C)[C@]3(C)[C@H](O)C[C@]12C InChI=1S/C33H52N2O2/c1-22(8-7-17-35-21-23-14-18-34-19-15-23)24-13-16-31(4)27-11-9-25-26(10-12-28(36)30(25,2)3)33(27,6)29(37)20-32(24,31)5/h9,14-15,18-19,22,24,26-29,35-37H,7-8,10-13,16-17,20-21H2,1-6H3/t22-,24-,26-,27+,28+,29-,31+,32-,33+/m1/s1 FELJHFLEULJMOM-OXQNSESWSA-N 50537703 CHEMBL4641544 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 500 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537703&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 156016706 442139266 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50473352 Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 UDMBCSSLTHHNCD-KQYNXXCUSA-N 18137 AMP::CHEMBL752::US11185100, TABLE 7.3::[(2R,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydrogen phosphate;hydrate::adenosine 5 -monophosphate::{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1400 ChEMBL 10.1016/j.bmcl.2019.126790 10.7270/Q2WW7N79 31744674 Wang, J; Liu, J; Xie, Z; Li, J; Li, J; Hu, L Nanjing University of Chinese Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18137&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search AMP 12AS,1AER,1AM0,1AMU,1ANK,1AW4,1BKX,1C0A,1CJA,1CT9,1CVJ,1DEL,1DGS,1DMA,1DS5,1ECJ,1EFP,1EFV,1EXD,1EYJ,1EYK,1FA9,1FBP,1FJ9,1FPD,1FPE,1FPF,1FPG,1FPI,1FPJ,1FPL,1FRP,1FSA,1FTA,1FVI,1FYD,1G51,1GPH,1GPM,1GTS,1H3D,1HDI,1HTO,1HTQ,1HTT,1ISO,1J20,1JP4,1JWB,1K9Y,1KA0,1KHT,1KPF,1KTG,1KZ8,1LGR,1LTK,1MB9,1MC1,1MD9,1MDB,1MF0,1MF1,1MZV,1NH8,1NKS,1NSY,1NV7,1O0B,1O0C,1O94,1O95,1O96,1O97,1OBD,1OBG,1OBT,1ORE,1P8L,1PTW,1PYG,1QB8,1QF6,1QGX,1RAO,1RAW,1RDY,1RDZ,1ROR,1RY2,1S68,1SES,1SON,1T6Y,1T9G,1TB5,1TB7,1TBW,1TUU,1U9Z,1UA4,1UKZ,1UXN,1UXP,1UXU,1UXV,1V26,1V8S,1V9P,1VD1,1W0H,1WXE,1WXI,1X9N,1XQS,1YXU,1YYZ,1YZ0,1Z6S,1Z84,1Z8D,1ZAU,1ZBH,1ZBU,1ZJW,1ZN8,1ZN9,2A1T,2A1U,2A7X,2A86,2AK3,2ART,2BWJ,2C38,2C5S,2CFM,2CNQ,2D1Q,2D1R,2DCL,2DEU,2DQ1,2DSD,2ECK,2F17,2F3D,2F3H,2FJB,2G1U,2GM3,2GMK,2GSU,2GXQ,2GXS,2HBL,2HCR,2I4I,2IVT,2J91,2J9D,2JGD,2NSY,2OOX,2OUN,2OWO,2P2F,2PTQ,2PZA,2Q2T,2Q4H,2Q8M,2QGA,2UV4,2UV6,2UV7,2V8Q,2V92,2V9J,3FIT,4FBP,6GPB,7GPB,8GPB 6083 46518246 16027 CHEMBL752 DB00131 2455 C00020 ZINC03860156 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43 50726291 C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 InChI=1S/C19H23N7O/c1-12-6-15(12)19(27)26-5-4-25(10-13(26)2)17-9-21-16(7-20)18(23-17)14-8-22-24(3)11-14/h8-9,11-13,15H,4-6,10H2,1-3H3/t12-,13-,15-/m1/s1 GXEXIUKEWXZCEF-UMVBOHGHSA-N 50537742 CHEMBL4634634::US11179389, Compound 1-14 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 >100000 ChEMBL 10.1016/j.bmcl.2019.126715 10.7270/Q2HM5CZG 31757666 Zhou, H; McGowan, MA; Lipford, K; Christopher, M; Fradera, X; Witter, D; Lesburg, CA; Li, C; Methot, JL; Lampe, J; Achab, A; Shaffer, L; Goldenblatt, P; Shah, S; Bass, A; Schroeder, G; Chen, D; Zeng, H; Augustin, MA; Katz, JD Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000057&target=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537742&enzyme=5%27-AMP-activated+protein+kinase+catalytic+subunit+alpha-2%2Fsubunit+beta-1%2Fsubunit+gamma-1&column=ki&startPg=0&Increment=50&submit=Search 5D 6OCU 145704650 442139305 3 MGNTSSERAALERHGGHKTPRRDSSGGTKDGDRPKILMDSPEDADLFHSEEIKAPEKEEFLAWQHDLEVNDKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYVCKPEERFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI 4CFE,4CFF,4ZHX,5EZV,5ISO,6B1U,6C9F,6C9G,6C9H,6C9J,7MYJ 5'-AMP-activated protein kinase subunit beta-1 AAKB1_HUMAN Q9Y478 Q9UBV0 Q9UE20 Q9UEX2 Q9Y6V8 METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP 2UV4,2UV5,4CFE,4CFF,4RER,4REW,4ZHX,5EZV,5ISO,6B1U,6B2E,6C9F,6C9G,6C9H,6C9J,7JHG,7JHH,7JIJ,7M74,7MYJ 5'-AMP-activated protein kinase subunit gamma-1 AAKG1_HUMAN P54619 B4DDT7 Q8N7V9 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR 2H6D,2LTU,4CFE,4CFF,5ISO 5'-AMP-activated protein kinase catalytic subunit alpha-2 AAPK2_HUMAN P54646 Q9H1E8 Q9UD43