BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1417581 Oc1ccc2c(oc(c(Oc3ccccc3)c2=O)C(F)(F)F)c1O InChI=1S/C16H9F3O5/c17-16(18,19)15-14(23-8-4-2-1-3-5-8)11(21)9-6-7-10(20)12(22)13(9)24-15/h1-7,20,22H ZXCSDLFJAHLZJC-UHFFFAOYSA-N 677285 US20240174649, Compound 33 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 2800 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677285&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 5322251 500592955 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417582 Oc1ccc2c(oc(c(Oc3ccccc3)c2=O)C(F)(F)F)c1O InChI=1S/C16H9F3O5/c17-16(18,19)15-14(23-8-4-2-1-3-5-8)11(21)9-6-7-10(20)12(22)13(9)24-15/h1-7,20,22H ZXCSDLFJAHLZJC-UHFFFAOYSA-N 677285 US20240174649, Compound 33 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 1840 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677285&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 5322251 500592955 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417583 Cc1oc2c(O)c(O)ccc2c(=O)c1Oc1ccccc1 InChI=1S/C16H12O5/c1-9-15(21-10-5-3-2-4-6-10)13(18)11-7-8-12(17)14(19)16(11)20-9/h2-8,17,19H,1H3 WOQXPLPDTBCBCT-UHFFFAOYSA-N 677286 US20240174649, Compound 33-2 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 8900 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677286&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 5400219 500592956 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417584 Cc1oc2c(O)c(O)ccc2c(=O)c1Oc1ccccc1 InChI=1S/C16H12O5/c1-9-15(21-10-5-3-2-4-6-10)13(18)11-7-8-12(17)14(19)16(11)20-9/h2-8,17,19H,1H3 WOQXPLPDTBCBCT-UHFFFAOYSA-N 677286 US20240174649, Compound 33-2 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 15000 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677286&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 5400219 500592956 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417585 COc1ccc2c(oc(C)c(Oc3ccccc3)c2=O)c1OO InChI=1S/C17H14O6/c1-10-15(22-11-6-4-3-5-7-11)14(18)12-8-9-13(20-2)17(23-19)16(12)21-10/h3-9,19H,1-2H3 NSAPEARRHMMKSK-UHFFFAOYSA-N 677287 US20240174649, Compound 33-3 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens >500000 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677287&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 171594341 500592957 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417586 FC(F)(F)c1oc2c3OCOc3ccc2c(=O)c1Oc1ccccc1 InChI=1S/C17H9F3O5/c18-17(19,20)16-15(24-9-4-2-1-3-5-9)12(21)10-6-7-11-14(13(10)25-16)23-8-22-11/h1-7H,8H2 RZELKPBTUIJGOO-UHFFFAOYSA-N 677288 US20240174649, Compound 33-4 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 80000 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677288&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 1039868 500592958 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417587 FC(F)(F)c1oc2c3OCOc3ccc2c(=O)c1Oc1ccccc1 InChI=1S/C17H9F3O5/c18-17(19,20)16-15(24-9-4-2-1-3-5-9)12(21)10-6-7-11-14(13(10)25-16)23-8-22-11/h1-7H,8H2 RZELKPBTUIJGOO-UHFFFAOYSA-N 677288 US20240174649, Compound 33-4 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 19000 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677288&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 1039868 500592958 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417588 FC(F)(F)c1oc2c3OCCOc3ccc2c(=O)c1Oc1ccccc1 InChI=1S/C18H11F3O5/c19-18(20,21)17-16(25-10-4-2-1-3-5-10)13(22)11-6-7-12-15(14(11)26-17)24-9-8-23-12/h1-7H,8-9H2 HPRMZIHICWJIMZ-UHFFFAOYSA-N 677289 US20240174649, Compound 33-5 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 48000 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677289&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 2055077 500592959 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417589 Oc1ccc2c(c1)oc(c(Oc1ccccc1)c2=O)C(F)(F)F InChI=1S/C16H9F3O4/c17-16(18,19)15-14(22-10-4-2-1-3-5-10)13(21)11-7-6-9(20)8-12(11)23-15/h1-8,20H FDXSCZFRCZEOGP-UHFFFAOYSA-N 677290 US20240174649, Compound 33-7 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 57000 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677290&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 5322253 500592960 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417596 Oc1c(Br)cc2c(oc(c(Oc3ccccc3)c2=O)C(F)(F)F)c1O InChI=1S/C16H8BrF3O5/c17-9-6-8-10(21)14(24-7-4-2-1-3-5-7)15(16(18,19)20)25-13(8)12(23)11(9)22/h1-6,22-23H BLSVREFZBLLMLH-UHFFFAOYSA-N 677297 US20240174649, Example Table9.1 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 3100 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677297&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603804 500592967 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417597 Oc1c(Br)cc2c(oc(c(Oc3ccccc3)c2=O)C(F)(F)F)c1O InChI=1S/C16H8BrF3O5/c17-9-6-8-10(21)14(24-7-4-2-1-3-5-7)15(16(18,19)20)25-13(8)12(23)11(9)22/h1-6,22-23H BLSVREFZBLLMLH-UHFFFAOYSA-N 677297 US20240174649, Example Table9.1 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 1890 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677297&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603804 500592967 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417598 Oc1ccc2c(oc(c(Oc3ccc(Br)cc3)c2=O)C(F)(F)F)c1O InChI=1S/C16H8BrF3O5/c17-7-1-3-8(4-2-7)24-14-11(22)9-5-6-10(21)12(23)13(9)25-15(14)16(18,19)20/h1-6,21,23H GZVGQUWHNKICCD-UHFFFAOYSA-N 677298 US20240174649, Example Table9.2 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 3500 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677298&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603728 500592968 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417599 Oc1ccc2c(oc(c(Oc3ccc(Br)cc3)c2=O)C(F)(F)F)c1O InChI=1S/C16H8BrF3O5/c17-7-1-3-8(4-2-7)24-14-11(22)9-5-6-10(21)12(23)13(9)25-15(14)16(18,19)20/h1-6,21,23H GZVGQUWHNKICCD-UHFFFAOYSA-N 677298 US20240174649, Example Table9.2 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 1420 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677298&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603728 500592968 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417600 Oc1ccc2c(oc(c(Oc3cccc(Br)c3)c2=O)C(F)(F)F)c1O InChI=1S/C16H8BrF3O5/c17-7-2-1-3-8(6-7)24-14-11(22)9-4-5-10(21)12(23)13(9)25-15(14)16(18,19)20/h1-6,21,23H JEYHAUZKNGECEU-UHFFFAOYSA-N 677299 US20240174649, Example Table9.3 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 2400 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677299&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603765 500592969 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417601 Oc1ccc2c(oc(c(Oc3cccc(Br)c3)c2=O)C(F)(F)F)c1O InChI=1S/C16H8BrF3O5/c17-7-2-1-3-8(6-7)24-14-11(22)9-4-5-10(21)12(23)13(9)25-15(14)16(18,19)20/h1-6,21,23H JEYHAUZKNGECEU-UHFFFAOYSA-N 677299 US20240174649, Example Table9.3 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 1900 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677299&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603765 500592969 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417602 Oc1ccc2c(oc(c(Oc3ccccc3Br)c2=O)C(F)(F)F)c1O InChI=1S/C16H8BrF3O5/c17-8-3-1-2-4-10(8)24-14-11(22)7-5-6-9(21)12(23)13(7)25-15(14)16(18,19)20/h1-6,21,23H HOPJORAFVCMXME-UHFFFAOYSA-N 677300 US20240174649, Example Table9.4 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 2700 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677300&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603770 500592970 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417603 Oc1ccc2c(oc(c(Oc3ccccc3Br)c2=O)C(F)(F)F)c1O InChI=1S/C16H8BrF3O5/c17-8-3-1-2-4-10(8)24-14-11(22)7-5-6-9(21)12(23)13(7)25-15(14)16(18,19)20/h1-6,21,23H HOPJORAFVCMXME-UHFFFAOYSA-N 677300 US20240174649, Example Table9.4 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 1950 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677300&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603770 500592970 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417604 Oc1c(Br)cc2c(oc(c(Oc3ccc(Br)cc3)c2=O)C(F)(F)F)c1O InChI=1S/C16H7Br2F3O5/c17-6-1-3-7(4-2-6)25-14-10(22)8-5-9(18)11(23)12(24)13(8)26-15(14)16(19,20)21/h1-5,23-24H VRHYRULMHMRMML-UHFFFAOYSA-N 677301 US20240174649, Example Table9.5 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 8300 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677301&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603733 500592971 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE 1417605 Oc1c(Br)cc2c(oc(c(Oc3ccc(Br)cc3)c2=O)C(F)(F)F)c1O InChI=1S/C16H7Br2F3O5/c17-6-1-3-7(4-2-6)25-14-10(22)8-5-9(18)11(23)12(24)13(8)26-15(14)16(19,20)21/h1-5,23-24H VRHYRULMHMRMML-UHFFFAOYSA-N 677301 US20240174649, Example Table9.5 E3 ubiquitin-protein ligase RBX1/Cullin-4A Homo sapiens 1190 US Patent 10.7270/Q2N58RPB US20240174649 DEVITA, RJ; PAN, Z; HUYNH, KQ; MOUSTAKIM, M; WU, K; SUEBSUWONG, C; HOPKINS, BD; CHEN, P; LAZARUS, MB ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=677301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=403&target=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=677301&enzyme=E3+ubiquitin-protein+ligase+RBX1%2FCullin-4A&column=ki&startPg=0&Increment=50&submit=Search 164603733 500592971 2 MAAAMDVDTPSGTNSGAGKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH 8RHZ,8Q7R,8Q7H,8Q7E,8PQL,8OR4,8OR3,8OR2,8OR0,8KHP,8K9I,8JE1,8JAV,8JAS,8JAQ,8IJ1,8H3R,8H3Q,8H3A,8H38,8H37,8H36,8H35,8B3I,8B3G,7Z8B,7PLO,7B5S,7B5N,7B5M,7B5L,2HYE,1U6G,8H3F,8H34,8H33,8GQ6,8QU8,8R5H,5N4W,4A0L,4A0C,4A0K,7OKQ,6R7H,6R7F,1LDK,1LDJ,6R7I,8WDK E3 ubiquitin-protein ligase RBX1 RBX1_HUMAN P62877 B2RDY1 Q8N6Z8 Q9D1S2 Q9WUK9 Q9Y254 MADEAPRKGSFSALVGRTNGLTKPAALAAAPAKPGGAGGSKKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 2HYE