BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1110990 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cccc(CN2CCOCC2)c1 InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39) DJOVLOYCGXNVPI-UHFFFAOYSA-N 50164794 CHEMBL3798846::US11174250, Example Table4.1.1::US11319299, Comp. No. 57 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 9500 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164794&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 35Q 4QL1 91623360 341097539 CHEMBL3798846 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1110992 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C29H31F4N5O3/c1-36-6-8-38(9-7-36)26-5-3-20(21-14-19(2-4-24(21)30)18-37-10-12-41-13-11-37)15-25(26)35-28(40)22-17-34-27(39)16-23(22)29(31,32)33/h2-5,14-17H,6-13,18H2,1H3,(H,34,39)(H,35,40) HJPMPWYSTRBBLP-UHFFFAOYSA-N 525575 US11174250, Example 2::US11174250, Example Table4.1.2::US11174250, Example Table4.3.2 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 939 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525575&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199813 463789229 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1110995 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCC(F)CC2)ccc1F InChI=1S/C30H32F5N5O2/c1-38-10-12-40(13-11-38)27-5-3-20(22-14-19(2-4-25(22)32)18-39-8-6-21(31)7-9-39)15-26(27)37-29(42)23-17-36-28(41)16-24(23)30(33,34)35/h2-5,14-17,21H,6-13,18H2,1H3,(H,36,41)(H,37,42) LCHGERIHAPDZCU-UHFFFAOYSA-N 525578 US11174250, Example 73::US11174250, Example Table4.2.2 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 592 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525578&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199815 463789232 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1110998 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C29H31F4N5O3/c1-36-6-8-38(9-7-36)26-5-3-20(21-14-19(2-4-24(21)30)18-37-10-12-41-13-11-37)15-25(26)35-28(40)22-17-34-27(39)16-23(22)29(31,32)33/h2-5,14-17H,6-13,18H2,1H3,(H,34,39)(H,35,40) HJPMPWYSTRBBLP-UHFFFAOYSA-N 525575 US11174250, Example 2::US11174250, Example Table4.1.2::US11174250, Example Table4.3.2 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 939 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525575&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199813 463789229 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111002 C[C@H]1CN(Cc2ccc(F)c(c2)-c2ccc(N3CCN(C)CC3)c(NC(=O)c3c[nH]c(=O)cc3C(F)(F)F)c2)C[C@@H](C)O1 525583 US11174250, Example 1 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 764 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525583&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199819 463789236 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111004 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C29H31F4N5O3/c1-36-6-8-38(9-7-36)26-5-3-20(21-14-19(2-4-24(21)30)18-37-10-12-41-13-11-37)15-25(26)35-28(40)22-17-34-27(39)16-23(22)29(31,32)33/h2-5,14-17H,6-13,18H2,1H3,(H,34,39)(H,35,40) HJPMPWYSTRBBLP-UHFFFAOYSA-N 525575 US11174250, Example 2::US11174250, Example Table4.1.2::US11174250, Example Table4.3.2 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 939 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525575&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199813 463789229 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111006 COCOc1cc(F)c(cc1C(=O)NC(C)(C)CC(C)(C)C)-c1ccc(N2CCN(C)CC2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1 InChI=1S/C35H43F4N5O5/c1-33(2,3)19-34(4,5)42-32(47)23-15-22(26(36)17-29(23)49-20-48-7)21-8-9-28(44-12-10-43(6)11-13-44)27(14-21)41-31(46)24-18-40-30(45)16-25(24)35(37,38)39/h8-9,14-18H,10-13,19-20H2,1-7H3,(H,40,45)(H,41,46)(H,42,47) YOZWQAYOZCWKIG-UHFFFAOYSA-N 525585 US11174250, Example 3 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 966 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525585&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199820 463789237 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111010 CC(C)COc1ccc(F)c(c1)-c1ccc(N2CCN(C)CC2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1 InChI=1S/C28H30F4N4O3/c1-17(2)16-39-19-5-6-23(29)20(13-19)18-4-7-25(36-10-8-35(3)9-11-36)24(12-18)34-27(38)21-15-33-26(37)14-22(21)28(30,31)32/h4-7,12-15,17H,8-11,16H2,1-3H3,(H,33,37)(H,34,38) ZXGPMNRFVXJEBT-UHFFFAOYSA-N 525588 US11174250, Example 6 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2510 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525588&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199823 463789240 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111012 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CNC2CCCCC2)ccc1F InChI=1S/C31H35F4N5O2/c1-39-11-13-40(14-12-39)28-10-8-21(23-15-20(7-9-26(23)32)18-36-22-5-3-2-4-6-22)16-27(28)38-30(42)24-19-37-29(41)17-25(24)31(33,34)35/h7-10,15-17,19,22,36H,2-6,11-14,18H2,1H3,(H,37,41)(H,38,42) SYLSWCJVGKVJRP-UHFFFAOYSA-N 525589 US11174250, Example 7 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 216 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525589&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199824 463789241 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111014 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(OC2CCOCC2)nc1F InChI=1S/C28H29F4N5O4/c1-36-8-10-37(11-9-36)23-4-2-17(19-3-5-25(35-26(19)29)41-18-6-12-40-13-7-18)14-22(23)34-27(39)20-16-33-24(38)15-21(20)28(30,31)32/h2-5,14-16,18H,6-13H2,1H3,(H,33,38)(H,34,39) BKPFEHCOJLAUMD-UHFFFAOYSA-N 525590 US11174250, Example 8 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1480 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525590&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199825 463789242 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111018 CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(C)c(F)c(C)c1)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C31H36F2N4O2/c1-21-16-25(17-22(2)30(21)33)31(38)34-28-19-24(5-7-29(28)37-10-8-35(3)9-11-37)26-18-23(4-6-27(26)32)20-36-12-14-39-15-13-36/h4-7,16-19H,8-15,20H2,1-3H3,(H,34,38) CRJVRDBFAYGWJT-UHFFFAOYSA-N 525593 US11174250, Example 11 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 4430 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525593&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 137376385 463789245 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111021 CN1CCN(CC1)c1ccc(cc1NC(=O)c1cn(C)c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C30H33F4N5O3/c1-36-7-9-39(10-8-36)27-6-4-21(22-15-20(3-5-25(22)31)18-38-11-13-42-14-12-38)16-26(27)35-29(41)23-19-37(2)28(40)17-24(23)30(32,33)34/h3-6,15-17,19H,7-14,18H2,1-2H3,(H,35,41) KYEHLKFNXJSZRC-UHFFFAOYSA-N 525595 US11174250, Example 13 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 8980 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525595&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 137376569 463789247 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111024 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(OCC2CC2)ncc1F InChI=1S/C27H27F4N5O3/c1-35-6-8-36(9-7-35)23-5-4-17(18-11-25(33-14-21(18)28)39-15-16-2-3-16)10-22(23)34-26(38)19-13-32-24(37)12-20(19)27(29,30)31/h4-5,10-14,16H,2-3,6-9,15H2,1H3,(H,32,37)(H,34,38) MCGJZXZCEBZTRU-UHFFFAOYSA-N 525597 US11174250, Example 15 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2250 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525597&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199828 463789249 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111026 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(OCC2CC2)nc1F InChI=1S/C27H27F4N5O3/c1-35-8-10-36(11-9-35)22-6-4-17(18-5-7-24(34-25(18)28)39-15-16-2-3-16)12-21(22)33-26(38)19-14-32-23(37)13-20(19)27(29,30)31/h4-7,12-14,16H,2-3,8-11,15H2,1H3,(H,32,37)(H,33,38) LRFLJHLBEGFWNW-UHFFFAOYSA-N 525598 US11174250, Example 16 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1470 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525598&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199829 463789250 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111037 CC1CN(CCN1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F 525608 US11174250, Example 26 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 779 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525608&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199835 463789260 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111039 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F 525609 US11174250, Example 27 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 529 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525609&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199836 463789261 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111042 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C29H34FN5O3/c1-20-15-28(36)31-18-24(20)29(37)32-26-17-22(4-6-27(26)35-9-7-33(2)8-10-35)23-16-21(3-5-25(23)30)19-34-11-13-38-14-12-34/h3-6,15-18H,7-14,19H2,1-2H3,(H,31,36)(H,32,37) VWJOEOAQIKTGBE-UHFFFAOYSA-N 525611 US11174250, Example 29 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 26700 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525611&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199838 463789263 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111044 CN1CCN(CC1)c1cc(F)c(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C29H30F5N5O3/c1-37-4-6-39(7-5-37)26-15-24(31)20(19-12-18(2-3-23(19)30)17-38-8-10-42-11-9-38)13-25(26)36-28(41)21-16-35-27(40)14-22(21)29(32,33)34/h2-3,12-16H,4-11,17H2,1H3,(H,35,40)(H,36,41) JYVWWLIWJLNTAD-UHFFFAOYSA-N 525612 US11174250, Example 30::US11319299, Example 43 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 15700 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525612&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199839 463789264 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111046 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(OC2CCOCC2)ncc1F InChI=1S/C28H29F4N5O4/c1-36-6-8-37(9-7-36)24-3-2-17(19-13-26(34-16-22(19)29)41-18-4-10-40-11-5-18)12-23(24)35-27(39)20-15-33-25(38)14-21(20)28(30,31)32/h2-3,12-16,18H,4-11H2,1H3,(H,33,38)(H,35,39) ACXYOZFCRYNCTJ-UHFFFAOYSA-N 525613 US11174250, Example 31 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1740 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525613&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199840 463789265 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111048 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(ccc1F)C(=O)NC1CCCCC1 InChI=1S/C31H33F4N5O3/c1-39-11-13-40(14-12-39)27-10-8-19(16-26(27)38-30(43)23-18-36-28(41)17-24(23)31(33,34)35)22-15-20(7-9-25(22)32)29(42)37-21-5-3-2-4-6-21/h7-10,15-18,21H,2-6,11-14H2,1H3,(H,36,41)(H,37,42)(H,38,43) GLHJOTVYVUCLQO-UHFFFAOYSA-N 525582 US11174250, Example 32::US11174250, Example Table4.4.2 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 332 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525582&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199818 463789235 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111050 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(CNC2CCCC2)cc1F InChI=1S/C30H33F4N5O2/c1-38-10-12-39(13-11-38)27-9-7-20(22-8-6-19(14-25(22)31)17-35-21-4-2-3-5-21)15-26(27)37-29(41)23-18-36-28(40)16-24(23)30(32,33)34/h6-9,14-16,18,21,35H,2-5,10-13,17H2,1H3,(H,36,40)(H,37,41) HEBOREHIASXCQK-UHFFFAOYSA-N 525615 US11174250, Example 33 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 8450 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525615&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199841 463789266 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111052 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(CNC2CCCCC2)cc1F InChI=1S/C31H35F4N5O2/c1-39-11-13-40(14-12-39)28-10-8-21(23-9-7-20(15-26(23)32)18-36-22-5-3-2-4-6-22)16-27(28)38-30(42)24-19-37-29(41)17-25(24)31(33,34)35/h7-10,15-17,19,22,36H,2-6,11-14,18H2,1H3,(H,37,41)(H,38,42) BWGYDAIKRMRFTQ-UHFFFAOYSA-N 525616 US11174250, Example 34 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 13700 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525616&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199842 463789267 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111054 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CNC(C)(C)C)ccc1F InChI=1S/C29H33F4N5O2/c1-28(2,3)35-16-18-5-7-23(30)20(13-18)19-6-8-25(38-11-9-37(4)10-12-38)24(14-19)36-27(40)21-17-34-26(39)15-22(21)29(31,32)33/h5-8,13-15,17,35H,9-12,16H2,1-4H3,(H,34,39)(H,36,40) KFTPIHQLXRHCSW-UHFFFAOYSA-N 525617 US11174250, Example 35 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2390 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525617&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199843 463789268 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111056 CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(F)c(C)c1)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C30H34F2N4O2/c1-21-17-24(4-7-26(21)31)30(37)33-28-19-23(5-8-29(28)36-11-9-34(2)10-12-36)25-18-22(3-6-27(25)32)20-35-13-15-38-16-14-35/h3-8,17-19H,9-16,20H2,1-2H3,(H,33,37) KQIMORZBKVLGNE-UHFFFAOYSA-N 525618 US11174250, Example 36 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] >30000 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525618&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 137376652 463789269 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111058 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CNC2CCOCC2)ccc1F InChI=1S/C30H33F4N5O3/c1-38-8-10-39(11-9-38)27-5-3-20(22-14-19(2-4-25(22)31)17-35-21-6-12-42-13-7-21)15-26(27)37-29(41)23-18-36-28(40)16-24(23)30(32,33)34/h2-5,14-16,18,21,35H,6-13,17H2,1H3,(H,36,40)(H,37,41) AVUKHGKRUAUGJG-UHFFFAOYSA-N 525619 US11174250, Example 37 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1300 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525619&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199844 463789270 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111060 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(CN2CCOCC2)cc1F InChI=1S/C29H31F4N5O3/c1-36-6-8-38(9-7-36)26-5-3-20(21-4-2-19(14-24(21)30)18-37-10-12-41-13-11-37)15-25(26)35-28(40)22-17-34-27(39)16-23(22)29(31,32)33/h2-5,14-17H,6-13,18H2,1H3,(H,34,39)(H,35,40) RZMHVRYMGMZVQU-UHFFFAOYSA-N 525620 US11174250, Example 38 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 3990 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525620&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199845 463789271 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111062 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccnc(N2CCOCC2)c1F InChI=1S/C27H28F4N6O3/c1-35-6-8-36(9-7-35)22-3-2-17(18-4-5-32-25(24(18)28)37-10-12-40-13-11-37)14-21(22)34-26(39)19-16-33-23(38)15-20(19)27(29,30)31/h2-5,14-16H,6-13H2,1H3,(H,33,38)(H,34,39) LPAXCQJMGILCNC-UHFFFAOYSA-N 525621 US11174250, Example 39 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2510 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525621&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199846 463789272 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111064 CN(C)Cc1ccc(F)c(c1)-c1ccc(N2CCN(C)CC2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1 InChI=1S/C27H29F4N5O2/c1-34(2)16-17-4-6-22(28)19(12-17)18-5-7-24(36-10-8-35(3)9-11-36)23(13-18)33-26(38)20-15-32-25(37)14-21(20)27(29,30)31/h4-7,12-15H,8-11,16H2,1-3H3,(H,32,37)(H,33,38) GXQQAULZONMYCT-UHFFFAOYSA-N 525622 US11174250, Example 40 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 6290 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525622&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199847 463789273 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111066 CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(C)c(F)c(c1)C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C31H33F5N4O2/c1-20-15-23(17-25(29(20)33)31(34,35)36)30(41)37-27-18-22(4-6-28(27)40-9-7-38(2)8-10-40)24-16-21(3-5-26(24)32)19-39-11-13-42-14-12-39/h3-6,15-18H,7-14,19H2,1-2H3,(H,37,41) BOVKVTDVQGJRCJ-UHFFFAOYSA-N 525623 US11174250, Example 41 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] >30000 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525623&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 137376698 463789274 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111068 CN1CCN(CC1)c1ccc(cc1NC(=O)c1cnc(OCC[Si](C)(C)C)cc1C(F)(F)F)-c1cc(CNC2CCC(F)(F)CC2)ccc1F InChI=1S/C36H45F6N5O2Si/c1-46-13-15-47(16-14-46)32-8-6-25(27-19-24(5-7-30(27)37)22-43-26-9-11-35(38,39)12-10-26)20-31(32)45-34(48)28-23-44-33(21-29(28)36(40,41)42)49-17-18-50(2,3)4/h5-8,19-21,23,26,43H,9-18,22H2,1-4H3,(H,45,48) HGPCPTVSTUVIQI-UHFFFAOYSA-N 525624 US11174250, Example 42 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2280 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525624&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 141655775 463789275 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111070 CN(Cc1ccc(F)c(c1)-c1ccc(N2CCN(C)CC2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1)C1COC1 InChI=1S/C29H31F4N5O3/c1-36-7-9-38(10-8-36)26-6-4-19(21-11-18(3-5-24(21)30)15-37(2)20-16-41-17-20)12-25(26)35-28(40)22-14-34-27(39)13-23(22)29(31,32)33/h3-6,11-14,20H,7-10,15-17H2,1-2H3,(H,34,39)(H,35,40) RZGVKGLIYMLVJM-UHFFFAOYSA-N 525625 US11174250, Example 43 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 3250 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525625&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199848 463789276 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111072 CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C30H32F4N4O3/c1-36-8-10-38(11-9-36)28-7-3-21(24-16-20(2-6-26(24)31)19-37-12-14-41-15-13-37)17-27(28)35-29(40)23-5-4-22(39)18-25(23)30(32,33)34/h2-7,16-18,39H,8-15,19H2,1H3,(H,35,40) GDXSDWNVMRVNLW-UHFFFAOYSA-N 525626 US11174250, Example 44 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] >30000 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525626&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 137376359 463789277 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111074 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CNC2CCCCC2)ccc1F 525627 US11174250, Example 45 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 514 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525627&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199849 463789278 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111076 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(ccc1F)C(=O)NC1CCCCC1 525628 US11174250, Example 46 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 290 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525628&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199850 463789279 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111078 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(ccc1F)C(=O)N1CCOCC1 525629 US11174250, Example 47 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2390 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525629&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199851 463789280 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111080 CN1CCN(CC1)c1ccc(cc1NC(=O)c1cc(O)cc(F)c1F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C29H31F3N4O3/c1-34-6-8-36(9-7-34)27-5-3-20(15-26(27)33-29(38)23-16-21(37)17-25(31)28(23)32)22-14-19(2-4-24(22)30)18-35-10-12-39-13-11-35/h2-5,14-17,37H,6-13,18H2,1H3,(H,33,38) LDZZELJKEFFULJ-UHFFFAOYSA-N 525630 US11174250, Example 48 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 21300 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525630&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 137376704 463789281 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111082 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C29H32F3N5O3/c1-35-6-8-37(9-7-35)26-5-3-20(21-14-19(2-4-24(21)30)18-36-10-12-40-13-11-36)15-25(26)34-29(39)23-17-33-27(38)16-22(23)28(31)32/h2-5,14-17,28H,6-13,18H2,1H3,(H,33,38)(H,34,39) SNSKIDONUPQTCE-UHFFFAOYSA-N 525631 US11174250, Example 49 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1570 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525631&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199852 463789282 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111084 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(OCC2CC2)ncc1F 525632 US11174250, Example 50 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1790 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525632&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199853 463789283 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111095 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)cnc1F 525642 US11174250, Example 60 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1410 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525642&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199854 463789293 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111097 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)cnc1F InChI=1S/C28H30F4N6O3/c1-36-4-6-38(7-5-36)24-3-2-19(20-12-18(15-34-26(20)29)17-37-8-10-41-11-9-37)13-23(24)35-27(40)21-16-33-25(39)14-22(21)28(30,31)32/h2-3,12-16H,4-11,17H2,1H3,(H,33,39)(H,35,40) FZVHYHVJNVOCCK-UHFFFAOYSA-N 525643 US11174250, Example 61 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 4490 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525643&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199855 463789294 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111099 CCN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C30H33F4N5O3/c1-2-37-7-9-39(10-8-37)27-6-4-21(22-15-20(3-5-25(22)31)19-38-11-13-42-14-12-38)16-26(27)36-29(41)23-18-35-28(40)17-24(23)30(32,33)34/h3-6,15-18H,2,7-14,19H2,1H3,(H,35,40)(H,36,41) BEWURZMFMJZRIA-UHFFFAOYSA-N 525644 US11174250, Example 62 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 13500 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525644&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199856 463789295 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111101 CCN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CNC2CCCCC2)ccc1F InChI=1S/C32H37F4N5O2/c1-2-40-12-14-41(15-13-40)29-11-9-22(24-16-21(8-10-27(24)33)19-37-23-6-4-3-5-7-23)17-28(29)39-31(43)25-20-38-30(42)18-26(25)32(34,35)36/h8-11,16-18,20,23,37H,2-7,12-15,19H2,1H3,(H,38,42)(H,39,43) CGMHUMFZWIFNAO-UHFFFAOYSA-N 525645 US11174250, Example 63 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 5630 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525645&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199857 463789296 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111104 CN1CCN(CC1CO)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F 525647 US11174250, Example 65 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 7300 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525647&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199858 463789298 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111106 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCN(CC3CC3)CC2)ccc1F InChI=1S/C33H38F4N6O2/c1-40-8-14-43(15-9-40)30-7-5-24(17-29(30)39-32(45)26-19-38-31(44)18-27(26)33(35,36)37)25-16-23(4-6-28(25)34)21-42-12-10-41(11-13-42)20-22-2-3-22/h4-7,16-19,22H,2-3,8-15,20-21H2,1H3,(H,38,44)(H,39,45) UCIMUGNNMDZMDT-UHFFFAOYSA-N 525648 US11174250, Example 66 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1100 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525648&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199859 463789299 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111108 CN(Cc1ccc(F)c(c1)-c1ccc(N2CCN(C)CC2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1)C1CCCCC1 InChI=1S/C32H37F4N5O2/c1-39-12-14-41(15-13-39)29-11-9-22(17-28(29)38-31(43)25-19-37-30(42)18-26(25)32(34,35)36)24-16-21(8-10-27(24)33)20-40(2)23-6-4-3-5-7-23/h8-11,16-19,23H,3-7,12-15,20H2,1-2H3,(H,37,42)(H,38,43) KZGBALJQZBEHNW-UHFFFAOYSA-N 525649 US11174250, Example 67 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1150 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525649&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199860 463789300 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111110 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCN(Cc3ccc(F)cc3)CC2)ccc1F InChI=1S/C36H37F5N6O2/c1-44-10-16-47(17-11-44)33-9-5-26(19-32(33)43-35(49)29-21-42-34(48)20-30(29)36(39,40)41)28-18-25(4-8-31(28)38)23-46-14-12-45(13-15-46)22-24-2-6-27(37)7-3-24/h2-9,18-21H,10-17,22-23H2,1H3,(H,42,48)(H,43,49) MSVYPKVNSDNBMD-UHFFFAOYSA-N 525650 US11174250, Example 68 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1890 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525650&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199861 463789301 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111112 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CC[C@@H](O)C2)ccc1F 525651 US11174250, Example 69 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2890 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525651&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199862 463789302 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111114 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCC(CC2)N2CCOCC2)ccc1F InChI=1S/C34H40F4N6O3/c1-41-10-12-44(13-11-41)31-5-3-24(19-30(31)40-33(46)27-21-39-32(45)20-28(27)34(36,37)38)26-18-23(2-4-29(26)35)22-42-8-6-25(7-9-42)43-14-16-47-17-15-43/h2-5,18-21,25H,6-17,22H2,1H3,(H,39,45)(H,40,46) ZXQPWVCTBWBJLE-UHFFFAOYSA-N 525652 US11174250, Example 70 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1110 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525652&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199863 463789303 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111116 CN(C)[C@@H]1CCN(Cc2ccc(F)c(c2)-c2ccc(N3CCN(C)CC3)c(NC(=O)c3c[nH]c(=O)cc3C(F)(F)F)c2)C1 525653 US11174250, Example 71 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2070 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525653&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199864 463789304 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111118 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCNCC2)ccc1F InChI=1S/C29H32F4N6O2/c1-37-10-12-39(13-11-37)26-5-3-20(21-14-19(2-4-24(21)30)18-38-8-6-34-7-9-38)15-25(26)36-28(41)22-17-35-27(40)16-23(22)29(31,32)33/h2-5,14-17,34H,6-13,18H2,1H3,(H,35,40)(H,36,41) RDIJFNQKWLWKCS-UHFFFAOYSA-N 525654 US11174250, Example 72 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 5930 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525654&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199865 463789305 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111120 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCC(F)CC2)ccc1F InChI=1S/C30H32F5N5O2/c1-38-10-12-40(13-11-38)27-5-3-20(22-14-19(2-4-25(22)32)18-39-8-6-21(31)7-9-39)15-26(27)37-29(42)23-17-36-28(41)16-24(23)30(33,34)35/h2-5,14-17,21H,6-13,18H2,1H3,(H,36,41)(H,37,42) LCHGERIHAPDZCU-UHFFFAOYSA-N 525578 US11174250, Example 73::US11174250, Example Table4.2.2 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 592 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525578&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199815 463789232 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111122 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2C3CC2COC3)ccc1F 525656 US11174250, Example 74 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1750 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525656&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199866 463789306 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111124 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CC[C@H](C2)S(C)(=O)=O)ccc1F 525657 US11174250, Example 75 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2090 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525657&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199867 463789307 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111126 CN(Cc1ccc(F)c(c1)-c1ccc(N2CCN(C)CC2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1)[C@H]1CCOC1 525658 US11174250, Example 76 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1900 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525658&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199868 463789308 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111128 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOC(C)(C)C2)ccc1F InChI=1S/C31H35F4N5O3/c1-30(2)19-39(12-13-43-30)18-20-4-6-25(32)22(14-20)21-5-7-27(40-10-8-38(3)9-11-40)26(15-21)37-29(42)23-17-36-28(41)16-24(23)31(33,34)35/h4-7,14-17H,8-13,18-19H2,1-3H3,(H,36,41)(H,37,42) XXBPCORNASWFLI-UHFFFAOYSA-N 525659 US11174250, Example 77 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 907 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525659&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199869 463789309 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111132 CN1CCN(CC1=O)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(ccc1F)C(=O)NC1CCCCC1 InChI=1S/C31H31F4N5O4/c1-39-11-12-40(17-28(39)42)26-10-8-18(14-25(26)38-30(44)22-16-36-27(41)15-23(22)31(33,34)35)21-13-19(7-9-24(21)32)29(43)37-20-5-3-2-4-6-20/h7-10,13-16,20H,2-6,11-12,17H2,1H3,(H,36,41)(H,37,43)(H,38,44) AJEAVPDKUNNESV-UHFFFAOYSA-N 525662 US11174250, Example 80 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 3990 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525662&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199872 463789312 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111134 CC1CN(CCN1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(ccc1F)C(=O)NC1CCCCC1 525663 US11174250, Example 81 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] >30000 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525663&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199873 463789313 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111136 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(OCC2CC2)nc1F 525664 US11174250, Example 82 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 549 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525664&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199874 463789314 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111139 CN1CCN(CC1)c1ncc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C28H30F4N6O3/c1-36-4-6-38(7-5-36)26-24(35-27(40)21-16-33-25(39)14-22(21)28(30,31)32)13-19(15-34-26)20-12-18(2-3-23(20)29)17-37-8-10-41-11-9-37/h2-3,12-16H,4-11,17H2,1H3,(H,33,39)(H,35,40) UOZGJWWPIWCEJI-UHFFFAOYSA-N 525666 US11174250, Example 84 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] >30000 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525666&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199876 463789316 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111143 CN(C)C1CCN(C1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F 525669 US11174250, Example 87 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 3890 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525669&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199878 463789318 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111147 CNC(=O)c1ccc(F)c(c1)-c1ccc(N2C[C@H](C)N(C)[C@H](C)C2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1 525672 US11174250, Example 90 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1093 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525672&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199880 463789321 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111151 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(ccc1F)C(=O)NC1CC1 525675 US11174250, Example 93 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 197 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525675&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199881 463789324 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111155 C[C@H]1CN(CCN1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ncccc1F 525678 US11174250, Example 96 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2534 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525678&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 137376461 463789327 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111158 CN1CCN(CC1)c1c(F)cc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C29H30F5N5O3/c1-37-4-6-39(7-5-37)27-24(31)13-19(20-12-18(2-3-23(20)30)17-38-8-10-42-11-9-38)14-25(27)36-28(41)21-16-35-26(40)15-22(21)29(32,33)34/h2-3,12-16H,4-11,17H2,1H3,(H,35,40)(H,36,41) FNMIGKXNLZEIGZ-UHFFFAOYSA-N 525680 US11174250, Example 98 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 40120 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525680&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199883 463789329 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111160 CN1CCN(CC1)c1ccc(c(F)c1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN2CCOCC2)ccc1F InChI=1S/C29H30F5N5O3/c1-37-6-8-39(9-7-37)24-5-3-19(20-14-18(2-4-23(20)30)17-38-10-12-42-13-11-38)26(31)27(24)36-28(41)21-16-35-25(40)15-22(21)29(32,33)34/h2-5,14-16H,6-13,17H2,1H3,(H,35,40)(H,36,41) PEHSNIFVIAESBC-UHFFFAOYSA-N 525681 US11174250, Example 99 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 3985 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525681&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199884 463789330 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111172 CN(C1CCCCC1)C(=O)c1ccc(F)c(c1)-c1ccc(N2CCN(C)CC2)c(NC(=O)c2c[nH]c(=O)cc2C(F)(F)F)c1 InChI=1S/C32H35F4N5O3/c1-39-12-14-41(15-13-39)28-11-9-20(17-27(28)38-30(43)24-19-37-29(42)18-25(24)32(34,35)36)23-16-21(8-10-26(23)33)31(44)40(2)22-6-4-3-5-7-22/h8-11,16-19,22H,3-7,12-15H2,1-2H3,(H,37,42)(H,38,43) LSSYDYCCKSSRBW-UHFFFAOYSA-N 525692 US11174250, Example 110 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 607 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525692&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199887 463789340 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111174 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(ccc1F)C(=O)N(C)C1CCCCC1 525693 US11174250, Example 111 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 203 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525693&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199888 463789341 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111177 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(CN(C)C2COC2)c(F)cc1F 525695 US11174250, Example 113 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 2100 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525695&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199890 463789343 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111179 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1c(F)ccc(CNC2CCCCC2)c1F 525696 US11174250, Example 114 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 11100 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525696&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199891 463789344 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111182 CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(ccc1Cl)C(=O)NC1CCCCC1 InChI=1S/C31H33ClF3N5O3/c1-39-11-13-40(14-12-39)27-10-8-19(16-26(27)38-30(43)23-18-36-28(41)17-24(23)31(33,34)35)22-15-20(7-9-25(22)32)29(42)37-21-5-3-2-4-6-21/h7-10,15-18,21H,2-6,11-14H2,1H3,(H,36,41)(H,37,42)(H,38,43) QYUSSNJDVILCJQ-UHFFFAOYSA-N 525581 US11174250, Example 116::US11174250, Example Table4.4.1 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 1900 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525581&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199817 463789234 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111191 CC1CN(CC(C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1cc(ccc1F)C(=O)NC1CCCCC1 525706 US11174250, Example 124 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 293 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525706&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 163199897 463789353 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7 1111193 C[C@H]1CN(C[C@@H](C)N1C)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1nc(ncc1F)N1CCOCC1 525707 US11174250, Example 125 P61964[22-334]/Q03164[3745-3969]/Q15291/Q9C005/Q9UBL3[2-534] 49.0 US Patent 10.7270/Q2C53Q0K aid1806104 US11174250 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A Propellon Therapeutics Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=346&target=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525707&enzyme=P61964%5B22-334%5D%2FQ03164%5B3745-3969%5D%2FQ15291%2FQ9C005%2FQ9UBL3%5B2-534%5D&column=ki&startPg=0&Increment=50&submit=Search 137376401 463789354 5 FRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 2W5Y,2W5Z,6KIU,6KIV,6KIX,6KIZ,7UD5 Histone-lysine N-methyltransferase 2A KMT2A_HUMAN Q03164 E9PQG7 Q13743 Q13744 Q14845 Q16364 Q59FF2 Q6UBD1 Q9HBJ3 Q9UD94 Q9UMA3 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC 2G99,2G9A,2GNQ,2H13,2H14,2H68,2H6K,2H6N,2H6Q,2XL2,2XL3,3EG6,3EMH,3MXX,3N0D,3N0E,3P4F,3PSL,3UVK,3UVL,3UVM,3UVN,3UVO,4A7J,4CY1,4CY2,4ERQ,4ERY,4ERZ,4ES0,4ESG,4EWR,4GM3,4GM8,4GM9,4GMB,4Y7R,5M23,5M25,5SXM,5VFC,6BYN,6D9X,6DAI,6DAK,6DAR,6DAS,6DY7,6DYA,6E1Y,6E1Z,6E22,6E23,6IAM,6KIU,6KIV,6KIW,6KIX,6KIZ,6OFZ,6OI0,6OI1,6OI2,6OI3,6PG3,6PG4,6PG5,6PG6,6PG7,6PG8,6PG9,6PGA,6PGB,6PGC,6PGD,6PGE,6PGF,6PWV,6PWW,6U5M,6U5Y,6U6W,6U80,6U8B,6U8L,6U8O,6UCS,6UHY,6UHZ,6UIF,6UIK,6UJ4,6UJH,6UJJ,6UJL,6UOZ,6W5I,6W5M,6W5N,6WJQ,7AXP,7AXQ,7AXS,7AXU,7AXX,7BCY,7BED,7CFP,7CFQ,7DNO,7JTO,7JTP,7MBM,7MBN,7U9Y,7UAS,7UD5,7WVK,8BB2,8BB3,8BB4,8BB5,8DU4,8E9F,8F1G,8F93,8G3C,8G3E WD repeat-containing protein 5 WDR5_HUMAN P61964 Q91VA5 Q9NWX7 Q9UGP9 AAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLK 3RSN,3S32,6KIU,6KIV,6KIW,6KIX,6KIZ,6PWV,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5 Set1/Ash2 histone methyltransferase complex subunit ASH2 ASH2L_HUMAN Q9UBL3 A8K7C3 D3DSW9 O60659 O60660 Q96B62 MEPEQMLEGQTQVAENPHSEYGLTDNVERIVENEKINAEKSSKQKVDLQSLPTRAYLDQTVVPILLQGLAVLAKERPPNPIEFLASYLLKNKAQFEDRN 4RIQ,4RT4,4RTA,6E2H,6PWV,7UD5 Protein dpy-30 homolog DPY30_HUMAN Q9C005 D6W578 MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL 6KIU,6KIV,6KIW,6KIX,6KIZ,6KM7,6PWV,6PWW,6PWX,6W5I,6W5M,6W5N,7MBM,7MBN,7UD5,8DU4 Retinoblastoma-binding protein 5 RBBP5_HUMAN Q15291 A8K272 Q7Z6D8 Q8NDZ7