BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence	PDB ID(s) of Target Chain	UniProt (SwissProt) Recommended Name of Target Chain	UniProt (SwissProt) Entry Name of Target Chain	UniProt (SwissProt) Primary ID of Target Chain	UniProt (SwissProt) Secondary ID(s) of Target Chain	UniProt (SwissProt) Alternative ID(s) of Target Chain	UniProt (TrEMBL) Submitted Name of Target Chain	UniProt (TrEMBL) Entry Name of Target Chain	UniProt (TrEMBL) Primary ID of Target Chain	UniProt (TrEMBL) Secondary ID(s) of Target Chain	UniProt (TrEMBL) Alternative ID(s) of Target Chain	BindingDB Target Chain Sequence	PDB ID(s) of Target Chain	UniProt (SwissProt) Recommended Name of Target Chain	UniProt (SwissProt) Entry Name of Target Chain	UniProt (SwissProt) Primary ID of Target Chain	UniProt (SwissProt) Secondary ID(s) of Target Chain	UniProt (SwissProt) Alternative ID(s) of Target Chain	UniProt (TrEMBL) Submitted Name of Target Chain	UniProt (TrEMBL) Entry Name of Target Chain	UniProt (TrEMBL) Primary ID of Target Chain	UniProt (TrEMBL) Secondary ID(s) of Target Chain	UniProt (TrEMBL) Alternative ID(s) of Target Chain
682928	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19-/m1/s1	MANPQCKCYFRFOG-VQIMIIECSA-N	319897	N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 64::US10202369, Example 64::US10472354, Example 64	P2X purinoceptor 2/3	Homo sapiens		 984							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319897&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397244	384223177							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682930	CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1	NHGFOVVSFOISFI-LOACHALJSA-N	319898	N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyL- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 65::US10202369, Example 65::US10472354, Example 65	P2X purinoceptor 2/3	Homo sapiens		 54.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319898&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397187	384223178							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682932	Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m0/s1	SKNHRCMFBDROGE-INIZCTEOSA-N	319899	N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 66::US10202369, Example 66::US10472354, Example 66	P2X purinoceptor 2/3	Homo sapiens		 6295							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319899&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397153	384223179							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682934	Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m0/s1	MFTNZVDLSIJVDH-INIZCTEOSA-N	319900	N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 67::US10202369, Example 67::US10472354, Example 67	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319900&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397127	384223180							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682936	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17+/m1/s1	VCKXOWQZUNTNDF-SJORKVTESA-N	319901	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 68::US10202369, Example 68::US10472354, Example 68	P2X purinoceptor 2/3	Homo sapiens		 1617							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319901&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397617	384223181							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682938	CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(24)8-18(25)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1	UNHVUPCUCRZLRC-LOACHALJSA-N	319902	N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 69::US10202369, Example 69::US10472354, Example 69	P2X purinoceptor 2/3	Homo sapiens		 937							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319902&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338444	384223182							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682940	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15+/m1/s1	CHPCVIFXIKJNGF-CABCVRRESA-N	319903	3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 70::US10202369, Example 70::US10472354, Example 70	P2X purinoceptor 2/3	Homo sapiens		 78.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319903&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397748	384223183							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682942	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17+/m1/s1	DJBMUKYGNBBQBO-SJORKVTESA-N	319904	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 71::US10202369, Example 71::US10472354, Example 71	P2X purinoceptor 2/3	Homo sapiens		 315							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319904&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397305	384223184							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682944	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15+/m1/s1	BICIIZABCQYPPY-CABCVRRESA-N	319905	3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 72::US10202369, Example 72::US10472354, Example 72	P2X purinoceptor 2/3	Homo sapiens		 330							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319905&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397781	384223185							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682946	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15-/m1/s1	CHPCVIFXIKJNGF-HUUCEWRRSA-N	319906	3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 73::US10202369, Example 73::US10472354, Example 73	P2X purinoceptor 2/3	Homo sapiens		 101							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319906&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397238	384223186							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682948	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17-/m1/s1	VCKXOWQZUNTNDF-IAGOWNOFSA-N	319907	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 74::US10202369, Example 74::US10472354, Example 74	P2X purinoceptor 2/3	Homo sapiens		 1107							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319907&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397532	384223187							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682950	Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m1/s1	SKNHRCMFBDROGE-MRXNPFEDSA-N	319908	N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 75::US10202369, Example 75::US10472354, Example 75	P2X purinoceptor 2/3	Homo sapiens		 6638							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319908&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397221	384223188							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682952	Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m1/s1	MFTNZVDLSIJVDH-MRXNPFEDSA-N	319909	N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 76::US10202369, Example 76::US10472354, Example 76	P2X purinoceptor 2/3	Homo sapiens		 5789							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319909&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397850	384223189							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682954	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17-/m1/s1	DJBMUKYGNBBQBO-IAGOWNOFSA-N	319910	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzomide::US10174016, Example 77::US10202369, Example 77::US10472354, Example 77	P2X purinoceptor 2/3	Homo sapiens		 183							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319910&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397806	384223190							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682956	CC(NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m1/s1	NHGFOVVSFOISFI-YSSOQSIOSA-N	319911	N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 78::US10202369, Example 78::US10472354, Example 78	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319911&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397720	384223191							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682958	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15-/m1/s1	BICIIZABCQYPPY-HUUCEWRRSA-N	319912	3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 79::US10202369, Example 79::US10472354, Example 79	P2X purinoceptor 2/3	Homo sapiens		 413							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319912&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397596	384223192							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682960	CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(24)10-17(25)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29)	SBZIYANVWYKJKX-UHFFFAOYSA-N	319913	N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 80::US10202369, Example 80::US10472354, Example 80	P2X purinoceptor 2/3	Homo sapiens		 339							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319913&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397324	384223193							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682962	CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(25)10-17(24)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29)	UXQVDYSQMZTJPS-UHFFFAOYSA-N	319914	N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 81::US10202369, Example 81::US10472354, Example 81	P2X purinoceptor 2/3	Homo sapiens		 34.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319914&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397622	384223194							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682964	Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-3-4-18(26-25-14)13-23-21(27)16-9-17(22-24-12-15(2)30-22)11-20(10-16)29-19-5-7-28-8-6-19/h3-4,9-12,19H,5-8,13H2,1-2H3,(H,23,27)	LSYGQIAUTJTZDJ-UHFFFAOYSA-N	319915	N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 82::US10202369, Example 82::US10472354, Example 82	P2X purinoceptor 2/3	Homo sapiens		 380							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319915&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397341	384223195							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682966	Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-14-10-24-18(12-23-14)13-25-21(27)16-7-17(22-26-11-15(2)30-22)9-20(8-16)29-19-3-5-28-6-4-19/h7-12,19H,3-6,13H2,1-2H3,(H,25,27)	YXUSESJBYZNMQE-UHFFFAOYSA-N	319916	N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 83::US10202369, Example 83::US10472354, Example 83	P2X purinoceptor 2/3	Homo sapiens		 1164							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319916&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397170	384223196							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682968	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-11-25-21(13-24-14)16(3)27-22(28)17-8-18(23-26-12-15(2)31-23)10-20(9-17)30-19-4-6-29-7-5-19/h8-13,16,19H,4-7H2,1-3H3,(H,27,28)/t16-/m1/s1	USCQOVGUOPYDKF-MRXNPFEDSA-N	319917	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 84::US10202369, Example 84::US10472354, Example 84	P2X purinoceptor 2/3	Homo sapiens		 527							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319917&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397618	384223197							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682970	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1	WGQQHPGXKFPPTQ-CQSZACIVSA-N	319918	3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 85::US10202369, Example 85::US10472354, Example 85	P2X purinoceptor 2/3	Homo sapiens		 36.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319918&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397801	384223198							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682972	COc1ccc(cn1)[C@@H](C)NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1	InChI=1S/C24H27N3O4S/c1-15-13-26-24(32-15)19-10-18(11-21(12-19)31-20-6-8-30-9-7-20)23(28)27-16(2)17-4-5-22(29-3)25-14-17/h4-5,10-14,16,20H,6-9H2,1-3H3,(H,27,28)/t16-/m1/s1	HOSIWEZQKWEZJW-MRXNPFEDSA-N	319919	N-[(1R)-1-(6- Methoxypyridin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 86::US10202369, Example 86::US10472354, Example 86	P2X purinoceptor 2/3	Homo sapiens		 144							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319919&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397310	384223199							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682974	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)17-10-18(23-24-13-15(2)31-23)12-20(11-17)30-19-6-8-29-9-7-19/h4-5,10-13,16,19H,6-9H2,1-3H3,(H,25,28)/t16-/m1/s1	OIHQARAAGWIFBW-MRXNPFEDSA-N	319920	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 87::US10202369, Example 87::US10472354, Example 87	P2X purinoceptor 2/3	Homo sapiens		 119							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319920&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397290	384223200							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682976	COc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(C)s2)nn1	InChI=1S/C22H24N4O4S/c1-14-12-24-22(31-14)16-9-15(10-19(11-16)30-18-5-7-29-8-6-18)21(27)23-13-17-3-4-20(28-2)26-25-17/h3-4,9-12,18H,5-8,13H2,1-2H3,(H,23,27)	FUPOQWQPMIFATK-UHFFFAOYSA-N	319921	N-[(6- Methoxy- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 88::US10202369, Example 88::US10472354, Example 88	P2X purinoceptor 2/3	Homo sapiens		 217							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319921	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319921&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397556	384223201							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682978	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-12-27-22(34-13)16-9-15(10-18(11-16)33-17-5-7-32-8-6-17)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,28,31)/t14-/m1/s1	RJKHHNIHJKFMMR-CQSZACIVSA-N	319922	3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin- 3-yl]ethyl} benzamide::US10174016, Example 89::US10202369, Example 89::US10472354, Example 89	P2X purinoceptor 2/3	Homo sapiens		 199							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319922&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397595	384223202							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682980	CC[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20(17-12-29-23(30-13-17)24(25,26)27)31-21(32)15-8-16(22-28-11-14(2)35-22)10-19(9-15)34-18-4-6-33-7-5-18/h8-13,18,20H,3-7H2,1-2H3,(H,31,32)/t20-/m1/s1	ULSBLOPPTNALIT-HXUWFJFHSA-N	319923	3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N-{(1R)- 1-[2- (trifluorometh- yl)pyrimidin-5- yl]propyl}benz- amide::US10174016, Example 90::US10202369, Example 90::US10472354, Example 90	P2X purinoceptor 2/3	Homo sapiens		 710							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319923&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397769	384223203							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682982	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C24H27N3O3S/c1-15-4-5-18(14-25-15)17(3)27-23(28)19-10-20(24-26-13-16(2)31-24)12-22(11-19)30-21-6-8-29-9-7-21/h4-5,10-14,17,21H,6-9H2,1-3H3,(H,27,28)/t17-/m1/s1	VKTBTGUHIBZLBJ-QGZVFWFLSA-N	319924	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 91::US10202369, Example 91::US10472354, Example 91	P2X purinoceptor 2/3	Homo sapiens		 133							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319924&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397502	384223204							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682984	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1	InChI=1S/C21H24N4O3S2/c1-12-11-22-21(29-12)16-8-15(9-18(10-16)28-17-4-6-27-7-5-17)19(26)23-13(2)20-25-24-14(3)30-20/h8-11,13,17H,4-7H2,1-3H3,(H,23,26)/t13-/m1/s1	GHXRECQLMZGPIV-CYBMUJFWSA-N	319925	N-[(1R)-1-(5- Methyl-1,3,4- thiadiazol-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 92::US10202369, Example 92::US10472354, Example 92	P2X purinoceptor 2/3	Homo sapiens		 317							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319925&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397542	384223205							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682986	Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-15-3-4-20(27-26-15)13-24-22(28)18-9-19(23-25-12-16(2)31-23)11-21(10-18)30-14-17-5-7-29-8-6-17/h3-4,9-12,17H,5-8,13-14H2,1-2H3,(H,24,28)	QOXIPNMWVVZPOQ-UHFFFAOYSA-N	319926	N-[(6- Methyl- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 93::US10202369, Example 93::US10472354, Example 93	P2X purinoceptor 2/3	Homo sapiens		 385							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319926&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397788	384223206							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682988	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-15-11-26-22(13-25-15)17(3)28-23(29)19-8-20(24-27-12-16(2)32-24)10-21(9-19)31-14-18-4-6-30-7-5-18/h8-13,17-18H,4-7,14H2,1-3H3,(H,28,29)/t17-/m1/s1	HCAZTDIYUNBLAC-QGZVFWFLSA-N	319927	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 94::US10202369, Example 94::US10472354, Example 94	P2X purinoceptor 2/3	Homo sapiens		 132							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319927&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397604	384223207							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682990	CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(26)10-19(25)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30)	WLBXKEKEIMKGRV-UHFFFAOYSA-N	319928	N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran--4- ylmethoxy) benzamide::US10174016, Example 95::US10202369, Example 95::US10472354, Example 95	P2X purinoceptor 2/3	Homo sapiens		 129							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319928&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397656	384223208							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682992	CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(25)10-19(26)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30)	YAVBCOZWMZVERS-UHFFFAOYSA-N	319929	N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 96::US10202369, Example 96::US10472354, Example 96	P2X purinoceptor 2/3	Homo sapiens		 1077							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319929&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397482	384223209							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683522	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20+/m1/s1	VDLXIDIXMUFWTI-UZLBHIALSA-N	320194	3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 361::US10202369, Example 361::US10472354, Example 361	P2X purinoceptor 2/3	Homo sapiens		 1254							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320194&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397445	384223467							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683524	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1	QQIYVSYWBHUFSE-BEFAXECRSA-N	320195	3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyridin-5- yl]ethyl} benzamide::US10174016, Example 362::US10202369, Example 362::US10472354, Example 362	P2X purinoceptor 2/3	Homo sapiens		 1014							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320195&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397415	384223468							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683526	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1	QQIYVSYWBHUFSE-DNVCBOLYSA-N	320193	3-{[(3R)-4-methylmorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 360::US10202369, Example 360::US10472354, Example 360	P2X purinoceptor 2/3	Homo sapiens		 717							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320193&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397664	384223466							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683528	C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F4N5O2S/c1-13-8-29-22(36-13)16-4-15(5-20(6-16)35-12-19-7-18(25)11-33(19)3)21(34)32-14(2)17-9-30-23(31-10-17)24(26,27)28/h4-6,8-10,14,18-19H,7,11-12H2,1-3H3,(H,32,34)/t14-,18?,19?/m1/s1	UCQIVXMFKURDDU-FTXHTYHOSA-N	320197	3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 364::US10202369, Example 364::US10472354, Example 364	P2X purinoceptor 2/3	Homo sapiens		 943							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320197&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397240	384223470							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683530	C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H26F4N4O2S/c1-14-10-31-24(36-14)18-6-17(7-21(8-18)35-13-20-9-19(26)12-33(20)3)23(34)32-15(2)16-4-5-22(30-11-16)25(27,28)29/h4-8,10-11,15,19-20H,9,12-13H2,1-3H3,(H,32,34)/t15-,19?,20?/m1/s1	XNRRWTQJTXNPEU-APMMTJHUSA-N	320198	3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 365::US10202369, Example 365::US10472354, Example 365	P2X purinoceptor 2/3	Homo sapiens		 1049							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320198&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397581	384223471							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683532	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21-/m1/s1	PQZKBUDIGDWISA-IIBYNOLFSA-N	320199	3-{[(2R)-4-methylmorpholin-2-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}benzamide::US10174016, Example 366::US10202369, Example 366::US10472354, Example 366	P2X purinoceptor 2/3	Homo sapiens		 977							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320199&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397655	384223472							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683534	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18-/m1/s1	AJIHXKQJGQMCEX-FZKQIMNGSA-N	320200	3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 367::US10202369, Example 367::US10472354, Example 367	P2X purinoceptor 2/3	Homo sapiens		 506							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320200&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397149	384223473							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683536	CN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1	InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m0/s1	VTYFKUULJMRVCQ-IBGZPJMESA-N	320201	3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 368::US10202369, Example 368::US10472354, Example 368	P2X purinoceptor 2/3	Homo sapiens		 1094							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320201&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397462	384223474							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683538	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F	InChI=1S/C25H28F2N4O3S/c1-15-11-29-25(35-15)19-8-18(9-20(10-19)34-14-21-13-31(3)6-7-33-21)24(32)30-16(2)17-4-5-22(23(26)27)28-12-17/h4-5,8-12,16,21,23H,6-7,13-14H2,1-3H3,(H,30,32)/t16-,21-/m1/s1	YEIOEBIHIRXRPN-IIBYNOLFSA-N	320202	N-{(1R)-1-[6- (difluoromethyl) pyridin-3- yl]ethyl}-3- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 369::US10202369, Example 369::US10472354, Example 369	P2X purinoceptor 2/3	Homo sapiens		 328							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320202&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397220	384223475							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683540	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21+/m1/s1	PQZKBUDIGDWISA-IERDGZPVSA-N	320203	3-{[(2S)-4- methylmorpholin 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 370::US10202369, Example 370::US10472354, Example 370	P2X purinoceptor 2/3	Homo sapiens		 1007							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320203&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397778	384223476							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683542	C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F4N5O2S/c1-13-7-28-20(35-13)16-4-15(5-18(6-16)34-12-22(24)10-32(3)11-22)19(33)31-14(2)17-8-29-21(30-9-17)23(25,26)27/h4-9,14H,10-12H2,1-3H3,(H,31,33)/t14-/m1/s1	UHPSIXSPUGVYFA-CQSZACIVSA-N	320204	3-[(3-fluoro-1- methylazetidin-3- yl}methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 371::US10202369, Example 371::US10472354, Example 371	P2X purinoceptor 2/3	Homo sapiens		 1173							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320204&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397234	384223477							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683544	CN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1	InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m1/s1	VTYFKUULJMRVCQ-LJQANCHMSA-N	320205	3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 372::US10202369, Example 372::US10472354, Example 372	P2X purinoceptor 2/3	Homo sapiens		 1211							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320205&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397797	384223478							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683546	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19-/m1/s1	IJFKDPNABTXGCF-DNVCBOLYSA-N	320206	3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 373::US10202369, Example 373::US10472354, Example 373	P2X purinoceptor 2/3	Homo sapiens		 2827							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320206&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397505	384223479							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683548	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19+/m1/s1	IJFKDPNABTXGCF-BEFAXECRSA-N	320207	3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 374::US10202369, Example 374::US10472354, Example 374	P2X purinoceptor 2/3	Homo sapiens		 2557							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320207&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397406	384223480							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683550	CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20+/m1/s1	PEGAFCGSQABLTK-QRWLVFNGSA-N	320208	3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methylmorpholin- 2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 375::US10202369, Example 375::US10472354, Example 375	P2X purinoceptor 2/3	Homo sapiens		 185							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320208&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397736	384223481							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683552	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18+/m1/s1	AJIHXKQJGQMCEX-ACJLOTCBSA-N	320209	3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 376::US10202369, Example 376::US10472354, Example 376	P2X purinoceptor 2/3	Homo sapiens		 898							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320209&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397674	384223482							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683554	CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20-/m1/s1	PEGAFCGSQABLTK-FOIQADDNSA-N	320210	3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 377::US10202369, Example 377::US10472354, Example 377	P2X purinoceptor 2/3	Homo sapiens		 273							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320210&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397144	384223483							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683556	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1	TYUJHJGDOVFFQY-BEFAXECRSA-N	320211	3-{[(2S)-1- methylpyrrolidin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 378::US10202369, Example 378::US10472354, Example 378	P2X purinoceptor 2/3	Homo sapiens		 3752							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320211&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397183	384223484							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683558	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1	TYUJHJGDOVFFQY-DNVCBOLYSA-N	320212	3-{[(2R)-1- methylpyrrolidin- 2-yl]methoxy}-5 (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 379::US10202369, Example 379::US10472354, Example 379	P2X purinoceptor 2/3	Homo sapiens		 2755							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320212&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397315	384223485							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683560	C[C@@H](NC(=O)c1cc(OCC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H28F3N5O2S/c1-15-11-29-23(36-15)19-8-18(9-21(10-19)35-14-17-4-6-33(3)7-5-17)22(34)32-16(2)20-12-30-24(31-13-20)25(26,27)28/h8-13,16-17H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1	GQMGTASPVLCRIR-MRXNPFEDSA-N	320213	3-[(1- methylpiperidin- 4-yl)methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 380::US10202369, Example 380::US10472354, Example 380	P2X purinoceptor 2/3	Homo sapiens		 2880							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320213&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397264	384223486							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683562	CC(C)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22-/m1/s1	AOHBYHNFISDLHQ-VGOFRKELSA-N	320214	3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 381::US10202369, Example 381::US10472354, Example 381	P2X purinoceptor 2/3	Homo sapiens		 954							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320214&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397576	384223487							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683564	CC(C)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22+/m1/s1	AOHBYHNFISDLHQ-VGSWGCGISA-N	320215	3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 382::US10202369, Example 382::US10472354, Example 382	P2X purinoceptor 2/3	Homo sapiens		 432							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320215&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397421	384223488							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683566	C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1	LGPVNMAGAZJDEW-NYRJJRHWSA-N	320216	3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 383::US10202369, Example 384::US10472354, Example 383	P2X purinoceptor 2/3	Homo sapiens		 35.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320216&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397497	384223489							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683568	C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1	LGPVNMAGAZJDEW-NYRJJRHWSA-N	320216	3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 383::US10202369, Example 384::US10472354, Example 383	P2X purinoceptor 2/3	Homo sapiens		 75.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320216&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397497	384223489							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683570	C[C@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m0/s1	LGPVNMAGAZJDEW-FUKCDUGKSA-N	322574	US10183937, Example 385::US10202369, Example 385	P2X purinoceptor 2/3	Homo sapiens		 28.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322574	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322574&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375418	384225634							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683572	C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C24H24F4N4O2S/c1-14-9-30-22(35-14)18-6-17(7-19(8-18)34-13-23(25)11-32(3)12-23)21(33)31-15(2)16-4-5-20(29-10-16)24(26,27)28/h4-10,15H,11-13H2,1-3H3,(H,31,33)/t15-/m1/s1	YWRAMSXXAJRPGK-OAHLLOKOSA-N	320219	3-[(3-fluoro-1- methylazetidin-3- yl)methoxy]-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 386::US10202369, Example 386::US10472354, Example 386	P2X purinoceptor 2/3	Homo sapiens		 811							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320219&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397321	384223491							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683574	CCc1cnc(s1)-c1cc(OCC2(F)CN(C)C2)cc(c1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H26F4N4O2S/c1-4-20-11-31-23(36-20)18-7-17(8-19(9-18)35-14-24(26)12-33(3)13-24)22(34)32-15(2)16-5-6-21(30-10-16)25(27,28)29/h5-11,15H,4,12-14H2,1-3H3,(H,32,34)/t15-/m1/s1	HCTVCZSENAWJEB-OAHLLOKOSA-N	320220	3-(5-ethyl-1,3- thiazol-2-yl)-5-[(3- fluoro-1- methylazetidin-3- yl)methoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 387::US10202369, Example 387::US10472354, Example 387	P2X purinoceptor 2/3	Homo sapiens		 461							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320220&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397751	384223492							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683576	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18-/m1/s1	SOWWCICJAYGBSY-CRAIPNDOSA-N	320221	3-{[(3R)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 388::US10202369, Example 388::US10472354, Example 388	P2X purinoceptor 2/3	Homo sapiens		 1353							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320221&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397768	384223493							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683578	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18+/m1/s1	SOWWCICJAYGBSY-QAPCUYQASA-N	320222	3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 389::US10202369, Example 389::US10472354, Example 389	P2X purinoceptor 2/3	Homo sapiens		 1614							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320222&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397449	384223494							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683580	CCN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21-/m1/s1	IJXNJADLTIUKEL-IIBYNOLFSA-N	320223	3-{[(2R)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 390::US10202369, Example 390::US10472354, Example 390	P2X purinoceptor 2/3	Homo sapiens		 804							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320223&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397822	384223495							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683582	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CC(F)F)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O3S/c1-14-8-31-23(39-14)17-5-16(22(36)34-15(2)18-9-32-24(33-10-18)25(28,29)30)6-19(7-17)38-13-20-11-35(3-4-37-20)12-21(26)27/h5-10,15,20-21H,3-4,11-13H2,1-2H3,(H,34,36)/t15-,20-/m1/s1	LANXVVYUHZPONS-FOIQADDNSA-N	320224	3-{[(2R)-4-(2,2-difluoroethyl)morpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 391::US10202369, Example 391::US10472354, Example 391	P2X purinoceptor 2/3	Homo sapiens		 840							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320224&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397746	384223496							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683584	COC(=O)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20-/m1/s1	AMNDVZJYNBRGRX-FOIQADDNSA-N	320225	Methyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 392::US10202369, Example 392::US10472354, Example 392	P2X purinoceptor 2/3	Homo sapiens		 411							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320225&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338451	384223497							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683586	COC(=O)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20+/m1/s1	AMNDVZJYNBRGRX-QRWLVFNGSA-N	320226	Methyl (2S)-2- {[3-(5-methyl- 1,3-thiazol-2- yl)-5-({(1R)-1- [2- (trifluoromethyl) pyrimidin-5-yl] ethyl}carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 393::US10202369, Example 393::US10472354, Example 393	P2X purinoceptor 2/3	Homo sapiens		 1033							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320226&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338452	384223498							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682994	Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-15-10-25-20(12-24-15)13-26-22(28)18-7-19(23-27-11-16(2)31-23)9-21(8-18)30-14-17-3-5-29-6-4-17/h7-12,17H,3-6,13-14H2,1-2H3,(H,26,28)	VSGRXICPAXTBHX-UHFFFAOYSA-N	319930	N-[(5- Methylpyrazin- 2- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 97::US10202369, Example 97::US10472354, Example 97	P2X purinoceptor 2/3	Homo sapiens		 1687							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319930&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397814	384223210							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682996	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-22(35-14)18-7-17(8-20(9-18)34-13-16-3-5-33-6-4-16)21(32)31-15(2)19-11-29-23(30-12-19)24(25,26)27/h7-12,15-16H,3-6,13H2,1-2H3,(H,31,32)/t15-/m1/s1	MBJQALPRFLKOPN-OAHLLOKOSA-N	319931	3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl] benzamide::US10174016, Example 98::US10202369, Example 98::US10472354, Example 98	P2X purinoceptor 2/3	Homo sapiens		 19.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319931&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397231	384223211							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682998	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-15-4-5-22(28-27-15)17(3)26-23(29)19-10-20(24-25-13-16(2)32-24)12-21(11-19)31-14-18-6-8-30-9-7-18/h4-5,10-13,17-18H,6-9,14H2,1-3H3,(H,26,29)/t17-/m1/s1	FNFCPAXHCILJLE-QGZVFWFLSA-N	319932	N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 99::US10202369, Example 99::US10472354, Example 99	P2X purinoceptor 2/3	Homo sapiens		 27.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319932&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397399	384223212							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683000	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C24H23N5O2S/c1-14-5-6-22(29-28-14)17(4)27-23(30)18-10-19(24-26-13-16(3)32-24)12-21(11-18)31-20-7-8-25-15(2)9-20/h5-13,17H,1-4H3,(H,27,30)/t17-/m1/s1	AOJXRFXYSRJHEO-QGZVFWFLSA-N	319933	N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 100::US10202369, Example 100::US10472354, Example 100	P2X purinoceptor 2/3	Homo sapiens		 16.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319933&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397202	384223213							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683002	Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C23H21N5O2S/c1-14-4-5-19(28-27-14)13-25-22(29)17-9-18(23-26-12-16(3)31-23)11-21(10-17)30-20-6-7-24-15(2)8-20/h4-12H,13H2,1-3H3,(H,25,29)	XCSQCNBYINKWNK-UHFFFAOYSA-N	319934	N-[(6- Methyl- pyridazin-3- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 101::US10202369, Example 101::US10472354, Example 101	P2X purinoceptor 2/3	Homo sapiens		 60.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319934&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397744	384223214							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683004	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C24H23N5O2S/c1-14-7-20(5-6-25-14)31-21-9-18(8-19(10-21)24-28-12-16(3)32-24)23(30)29-17(4)22-13-26-15(2)11-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1	QEKNBUCJINMCOL-QGZVFWFLSA-N	319935	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 102::US10202369, Example 102::US10472354, Example 102	P2X purinoceptor 2/3	Homo sapiens		 57.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319935&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397697	384223215							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683006	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H20F3N5O2S/c1-13-6-19(4-5-28-13)34-20-8-16(7-17(9-20)22-29-10-14(2)35-22)21(33)32-15(3)18-11-30-23(31-12-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1	JXFGKHKXOUTTKZ-OAHLLOKOSA-N	319936	3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl} benzamide::US10174016, Example 103::US10202369, Example 103::US10472354, Example 103	P2X purinoceptor 2/3	Homo sapiens		 14.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319936&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397214	384223216							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683008	Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C23H21N5O2S/c1-14-6-20(4-5-24-14)30-21-8-17(7-18(9-21)23-28-11-16(3)31-23)22(29)27-13-19-12-25-15(2)10-26-19/h4-12H,13H2,1-3H3,(H,27,29)	FHRXECCRJLFVTP-UHFFFAOYSA-N	319937	N-[(5- Methylpyrazin- 2- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 104::US10202369, Example 104::US10472354, Example 104	P2X purinoceptor 2/3	Homo sapiens		 377							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319937&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397645	384223217							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683010	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H20F3N5O2S/c1-13-8-18(6-7-28-13)34-19-10-16(9-17(11-19)23-29-12-14(2)35-23)22(33)30-15(3)20-4-5-21(32-31-20)24(25,26)27/h4-12,15H,1-3H3,(H,30,33)/t15-/m1/s1	DZQXNDYGTRQHHO-OAHLLOKOSA-N	319938	3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [6- (trifluorometh- yl)pyridazin- 3- yl]ethyl} benzamide::US10174016, Example 105::US10202369, Example 105::US10472354, Example 105	P2X purinoceptor 2/3	Homo sapiens		 39.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319938&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397847	384223218							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683012	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C24H23N5O2S/c1-14-7-21(5-6-25-14)31-22-9-18(8-19(10-22)24-28-11-15(2)32-24)23(30)29-16(3)20-12-26-17(4)27-13-20/h5-13,16H,1-4H3,(H,29,30)/t16-/m1/s1	AVOXIOANORGYFZ-MRXNPFEDSA-N	319939	3-[(2-methylpyridin-4-yl)oxy]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 106::US10202369, Example 106::US10472354, Example 106	P2X purinoceptor 2/3	Homo sapiens		 41.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319939&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397227	384223219							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683014	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C25H24N4O2S/c1-15-5-6-19(14-27-15)18(4)29-24(30)20-10-21(25-28-13-17(3)32-25)12-23(11-20)31-22-7-8-26-16(2)9-22/h5-14,18H,1-4H3,(H,29,30)/t18-/m1/s1	PNIOXTPFLIQKJT-GOSISDBHSA-N	319940	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 107::US10202369, Example 107::US10472354, Example 107	P2X purinoceptor 2/3	Homo sapiens		 17.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319940&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397329	384223220							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683016	C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H20F3N5O2S/c1-13-4-5-19(12-28-13)34-20-7-16(6-17(8-20)22-29-9-14(2)35-22)21(33)32-15(3)18-10-30-23(31-11-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1	ASXORIIIQIGPLA-OAHLLOKOSA-N	319941	3-[(6-Methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 108::US10202369, Example 108::US10472354, Example 108	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319941&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397249	384223221							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683018	C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C21H20N6O2S2/c1-11-8-23-18(10-22-11)13(3)25-19(28)15-5-16(20-24-9-12(2)30-20)7-17(6-15)29-21-27-26-14(4)31-21/h5-10,13H,1-4H3,(H,25,28)/t13-/m1/s1	SHPJQOXSFBKQMY-CYBMUJFWSA-N	319942	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- [(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 109::US10202369, Example 109::US10472354, Example 109	P2X purinoceptor 2/3	Homo sapiens		 2412							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319942&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397425	384223222							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683020	C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C21H20N6O2S2/c1-11-5-6-18(26-24-11)13(3)23-19(28)15-7-16(20-22-10-12(2)30-20)9-17(8-15)29-21-27-25-14(4)31-21/h5-10,13H,1-4H3,(H,23,28)/t13-/m1/s1	YBUIRLYLJALMRA-CYBMUJFWSA-N	319943	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-[(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 110::US10202369, Example 110::US10472354, Example 110	P2X purinoceptor 2/3	Homo sapiens		 1451							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319943&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397265	384223223							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683022	C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H17F3N6O2S2/c1-10-7-25-18(33-10)14-4-13(5-16(6-14)32-20-30-29-12(3)34-20)17(31)28-11(2)15-8-26-19(27-9-15)21(22,23)24/h4-9,11H,1-3H3,(H,28,31)/t11-/m1/s1	FIVDAXBJTLXBHI-LLVKDONJSA-N	319944	3-[(5-Methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 111::US10202369, Example 111::US10472354, Example 111	P2X purinoceptor 2/3	Homo sapiens		 380							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319944	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319944&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397223	384223224							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683024	C[C@@H](NC(=O)c1cc(Oc2nncs2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C20H18N6O2S2/c1-11-7-22-17(9-21-11)13(3)25-18(27)14-4-15(19-23-8-12(2)30-19)6-16(5-14)28-20-26-24-10-29-20/h4-10,13H,1-3H3,(H,25,27)/t13-/m1/s1	DSVXFYAUDDSSDL-CYBMUJFWSA-N	346125	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy) benzamide::US10202369, Example 112	P2X purinoceptor 2/3	Homo sapiens		 772							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346125	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346125&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134391356	385452176							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683026	C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C21H19N5O2S2/c1-12-4-5-18(26-25-12)14(3)24-19(27)15-8-16(20-23-11-13(2)30-20)10-17(9-15)28-21-22-6-7-29-21/h4-11,14H,1-3H3,(H,24,27)/t14-/m1/s1	KTZHJRKMBNLACT-CQSZACIVSA-N	319946	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(1,3- thiazol-2- yloxy)benzamide::US10174016, Example 113::US10202369, Example 113::US10472354, Example 113	P2X purinoceptor 2/3	Homo sapiens		 387							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319946&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397679	384223226							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683028	C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C22H20N4O2S2/c1-13-4-5-16(12-24-13)15(3)26-20(27)17-8-18(21-25-11-14(2)30-21)10-19(9-17)28-22-23-6-7-29-22/h4-12,15H,1-3H3,(H,26,27)/t15-/m1/s1	WJNIKDPPMLYZOS-OAHLLOKOSA-N	319947	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 114::US10202369, Example 114::US10472354, Example 114	P2X purinoceptor 2/3	Homo sapiens		 414							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319947&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397612	384223227							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683030	COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(Cl)cn1	InChI=1S/C22H23Cl2N3O3S/c1-13(18-6-5-16(23)10-25-18)27-20(28)14-7-15(21-26-11-19(24)31-21)9-17(8-14)30-12-22(2,3)29-4/h5-11,13H,12H2,1-4H3,(H,27,28)/t13-/m1/s1	MHZRDUGBKYAKKB-CYBMUJFWSA-N	319948	N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)benzamide::US10174016, Example 115::US10202369, Example 115::US10472354, Example 115	P2X purinoceptor 2/3	Homo sapiens		 187							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319948&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397201	384223228							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683032	COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H22ClF3N4O3S/c1-12(15-8-28-20(29-9-15)22(24,25)26)30-18(31)13-5-14(19-27-10-17(23)34-19)7-16(6-13)33-11-21(2,3)32-4/h5-10,12H,11H2,1-4H3,(H,30,31)/t12-/m1/s1	QSHVLLWXZBADRN-GFCCVEGCSA-N	319949	3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 116::US10202369, Example 116::US10472354, Example 116	P2X purinoceptor 2/3	Homo sapiens		 6430							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319949&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397235	384223229							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683034	COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C22H25ClN4O3S/c1-13-9-25-18(10-24-13)14(2)27-20(28)15-6-16(21-26-11-19(23)31-21)8-17(7-15)30-12-22(3,4)29-5/h6-11,14H,12H2,1-5H3,(H,27,28)/t14-/m1/s1	IVUVTQZOIPAQFU-CQSZACIVSA-N	319950	3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]benzamide::US10174016, Example 117::US10202369, Example 117::US10472354, Example 117	P2X purinoceptor 2/3	Homo sapiens		 883							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319950&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397711	384223230							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683036	Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C(F)(F)F)nn1	InChI=1S/C23H23F3N4O3S/c1-14-2-3-18(30-29-14)11-27-21(31)16-8-17(22-28-12-20(34-22)23(24,25)26)10-19(9-16)33-13-15-4-6-32-7-5-15/h2-3,8-10,12,15H,4-7,11,13H2,1H3,(H,27,31)	JVFRARFSFIRWBD-UHFFFAOYSA-N	319951	N-[(6-Methylpyridazin-3-yl)methyl]-3-(tetrahydro-2H-pyran-4-ylmethoxy)-5-[5-(trifluoromethyl)-1,3-thiazol-2-yl]benzamide::US10174016, Example 118::US10202369, Example 118::US10472354, Example 118	P2X purinoceptor 2/3	Homo sapiens		 1134							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319951	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319951&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397366	384223231							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683038	Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1	InChI=1S/C26H30N4O3S/c1-17-5-6-22(30-29-17)14-27-25(31)20-11-21(26-28-15-24(34-26)19-3-2-4-19)13-23(12-20)33-16-18-7-9-32-10-8-18/h5-6,11-13,15,18-19H,2-4,7-10,14,16H2,1H3,(H,27,31)	UIEYRDUAWDAEID-UHFFFAOYSA-N	319952	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 119::US10202369, Example 119::US10472354, Example 119	P2X purinoceptor 2/3	Homo sapiens		 190							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319952	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319952&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397447	384223232							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683040	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C27H29F3N4O3S/c1-16(21-12-32-26(33-13-21)27(28,29)30)34-24(35)19-9-20(25-31-14-23(38-25)18-3-2-4-18)11-22(10-19)37-15-17-5-7-36-8-6-17/h9-14,16-18H,2-8,15H2,1H3,(H,34,35)/t16-/m1/s1	XFOWUTGLWQUPCN-MRXNPFEDSA-N	319953	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-ylmethoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 120::US10202369, Example 120::US10472354, Example 120	P2X purinoceptor 2/3	Homo sapiens		 104							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319953	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319953&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397437	384223233							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683042	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18+/m1/s1	ZBRXLMDGZXDHGV-MSOLQXFVSA-N	319954	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 121::US10202369, Example 121::US10472354, Example 271	P2X purinoceptor 2/3	Homo sapiens		 279							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319954&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397486	384223234							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683044	Cc1ccc(CNC(=O)c2cc(OC[C@H]3CCOC3)cc(c2)-c2ncc(s2)C2CCC2)nn1	InChI=1S/C25H28N4O3S/c1-16-5-6-21(29-28-16)12-26-24(30)19-9-20(25-27-13-23(33-25)18-3-2-4-18)11-22(10-19)32-15-17-7-8-31-14-17/h5-6,9-11,13,17-18H,2-4,7-8,12,14-15H2,1H3,(H,26,30)/t17-/m0/s1	DCRIJNFHBDAZLX-KRWDZBQOSA-N	319955	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 122::US10202369, Example 122::US10472354, Example 122	P2X purinoceptor 2/3	Homo sapiens		 1167							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319955	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319955&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397270	384223235							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683046	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16+/m1/s1	JWRPHAGJMIAQMD-CVEARBPZSA-N	319956	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 123::US10202369, Example 123::US10472354, Example 272	P2X purinoceptor 2/3	Homo sapiens		 164							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319956&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397161	384223236							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683048	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)nc1	InChI=1S/C27H32N4O3S/c1-17(23-13-28-18(2)29-14-23)31-26(32)21-10-22(27-30-15-25(35-27)20-4-3-5-20)12-24(11-21)34-16-19-6-8-33-9-7-19/h10-15,17,19-20H,3-9,16H2,1-2H3,(H,31,32)/t17-/m1/s1	WEHPOEFAIDTUPC-QGZVFWFLSA-N	319957	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 124::US10202369, Example 124::US10472354, Example 124	P2X purinoceptor 2/3	Homo sapiens		 165							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319957&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397614	384223237							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683050	CCc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1	InChI=1S/C25H30N4O3S/c1-4-23-14-28-25(33-23)20-9-19(10-22(11-20)32-15-18-5-7-31-8-6-18)24(30)29-16(2)21-12-26-17(3)27-13-21/h9-14,16,18H,4-8,15H2,1-3H3,(H,29,30)/t16-/m1/s1	DTZIYRRTWOGOEN-MRXNPFEDSA-N	319958	3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 125::US10202369, Example 125::US10472354, Example 125	P2X purinoceptor 2/3	Homo sapiens		 27.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319958&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397256	384223238							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683052	CC(C)c1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1	InChI=1S/C26H32N4O3S/c1-16(2)24-14-29-26(34-24)21-9-20(10-23(11-21)33-15-19-5-7-32-8-6-19)25(31)30-17(3)22-12-27-18(4)28-13-22/h9-14,16-17,19H,5-8,15H2,1-4H3,(H,30,31)/t17-/m1/s1	OFIYJECBOJUELW-QGZVFWFLSA-N	319959	N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-[5-(propan-2-yl)-1,3-thiazol-2-yl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 126::US10202369, Example 126::US10472354, Example 126	P2X purinoceptor 2/3	Homo sapiens		 532							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319959&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397136	384223239							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683054	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)19-12-20(26-27-15-24(34-26)18-4-3-5-18)14-22(13-19)33-21-8-10-32-11-9-21/h6-7,12-15,17-18,21H,3-5,8-11H2,1-2H3,(H,28,31)/t17-/m1/s1	WWWCBSCSEOPHLV-QGZVFWFLSA-N	319960	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 127::US10202369, Example 127::US10472354, Example 127	P2X purinoceptor 2/3	Homo sapiens		 536							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319960&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397331	384223240							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683056	CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-14-25-24(32-21)18-11-17(12-20(13-18)31-19-7-9-30-10-8-19)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,11-14,16,19H,4,7-10H2,1-3H3,(H,26,29)/t16-/m1/s1	ZSPSPZOSCRXZOC-MRXNPFEDSA-N	319961	3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 128::US10202369, Example 128::US10472354, Example 128	P2X purinoceptor 2/3	Homo sapiens		 91.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319961&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397510	384223241							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683058	CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-13-28-22(35-20)16-8-15(9-19(10-16)34-18-4-6-33-7-5-18)21(32)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h8-14,18H,3-7H2,1-2H3,(H,31,32)/t14-/m1/s1	HAECKPIYFMDTPM-CQSZACIVSA-N	319962	3-(5-Ethyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 129::US10202369, Example 129::US10472354, Example 129	P2X purinoceptor 2/3	Homo sapiens		 33.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319962&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397362	384223242							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683588	C[C@@H](NC(=O)c1cc(OCC2CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H22F3N5O2S/c1-12-6-27-20(33-12)16-3-15(4-18(5-16)32-11-14-7-26-8-14)19(31)30-13(2)17-9-28-21(29-10-17)22(23,24)25/h3-6,9-10,13-14,26H,7-8,11H2,1-2H3,(H,30,31)/t13-/m1/s1	MHYFOJHMKOGSKR-CYBMUJFWSA-N	320227	3-(Azetidin-3-ylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 394::US10202369, Example 394::US10472354, Example 394	P2X purinoceptor 2/3	Homo sapiens		 3983							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320227&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397376	384223499							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683590	C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1	SDFLFPYVVNTAIN-RDTXWAMCSA-N	320228	3-{[(3R)-4-methyl-5-oxomorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 395::US10202369, Example 395::US10472354, Example 395	P2X purinoceptor 2/3	Homo sapiens		 1312							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320228&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397767	384223500							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683592	C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17-/m1/s1	QBCIMXIDQXCQLC-CXAGYDPISA-N	320229	3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3R)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 396::US10202369, Example 396::US10472354, Example 396	P2X purinoceptor 2/3	Homo sapiens		 1803							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320229&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397733	384223501							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683594	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18+/m1/s1	OAEQMLBAMDEFGR-ACJLOTCBSA-N	320230	3-{[(5S)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 397::US10202369, Example 397::US10472354, Example 397	P2X purinoceptor 2/3	Homo sapiens		 1362							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320230&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397304	384223502							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683596	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18-/m1/s1	OAEQMLBAMDEFGR-FZKQIMNGSA-N	320231	3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 398::US10202369, Example 398::US10472354, Example 398	P2X purinoceptor 2/3	Homo sapiens		 1795							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320231&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397297	384223503							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683598	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19-/m1/s1	UCMZCPXWJACEJN-AUUYWEPGSA-N	320232	3-{[(2R)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 399::US10202369, Example 399::US10472354, Example 399	P2X purinoceptor 2/3	Homo sapiens		 1722							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320232&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397565	384223504							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683600	C[C@@H](NC(=O)c1cc(OC[C@@H]2CNC(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-6-28-21(36-12)15-3-14(4-17(5-15)34-10-18-9-27-19(32)11-35-18)20(33)31-13(2)16-7-29-22(30-8-16)23(24,25)26/h3-8,13,18H,9-11H2,1-2H3,(H,27,32)(H,31,33)/t13-,18+/m1/s1	SQKDWNUUISQXQF-ACJLOTCBSA-N	320233	3-(5-methyl-1,3- thiazol-2-yl)-5- {[(2S)-5- oxomorpholin-2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 400::US10202369, Example 400::US10472354, Example 400	P2X purinoceptor 2/3	Homo sapiens		 1477							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320233&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397173	384223505							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683602	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19+/m1/s1	UCMZCPXWJACEJN-KUHUBIRLSA-N	320234	3-{[(2S)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 401::US10202369, Example 401::US10472354, Example 401	P2X purinoceptor 2/3	Homo sapiens		 1466							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320234&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397710	384223506							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683604	C[C@@H](NC(=O)c1cc(OC[C@@H]2COC(=O)CN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)35-11-18-12-36-20(33)10-32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1	JINXRBWBLDWPDI-RDTXWAMCSA-N	346415	3-{[(3S)-4-methyl-5- oxomorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol-2- yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10202369, Example 402	P2X purinoceptor 2/3	Homo sapiens		 1251							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346415	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346415&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134391360	385452461							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683606	C[C@@H](NC(=O)c1cc(OC[C@@H]2COC(=O)CN2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-6-28-21(36-12)15-3-14(4-18(5-15)34-10-17-11-35-19(32)9-27-17)20(33)31-13(2)16-7-29-22(30-8-16)23(24,25)26/h3-8,13,17,27H,9-11H2,1-2H3,(H,31,33)/t13-,17-/m1/s1	DQPJGRQHAAMQCH-CXAGYDPISA-N	346416	3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3S)-5- oxomorpholin-3- yl]methoxy}-N-{(1R)- 1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10202369, Example 403	P2X purinoceptor 2/3	Homo sapiens		 2108							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346416	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346416&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134391361	385452462							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683608	C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C29H32F3N5O5S/c1-16-10-33-24(43-16)19-6-18(23(38)36-17(2)20-11-34-25(35-12-20)29(30,31)32)7-22(8-19)40-15-28-9-21(13-41-28)37(14-28)26(39)42-27(3,4)5/h6-8,10-12,17,21H,9,13-15H2,1-5H3,(H,36,38)/t17-,21?,28?/m1/s1	FPSSQFUABOQNNZ-RWNQLPSJSA-N	320237	US10174016, Example 404::US10202369, Example 404::US10472354, Example 404::tert-butyl 1-{[3-(5- methyl-1,3-thiazol- 2-yl)-5-({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]methyl}-2- oxa-5- azabicyclo[2.2.1] heptane-5- carboxylate, as a mixture of 2 diastereoisomers	P2X purinoceptor 2/3	Homo sapiens		 533							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320237&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397508	384223509							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683610	CC(C)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2	InChI=1S/C27H30F3N5O3S/c1-15(2)35-13-26(8-21(35)12-38-26)14-37-22-6-18(5-19(7-22)24-31-9-16(3)39-24)23(36)34-17(4)20-10-32-25(33-11-20)27(28,29)30/h5-7,9-11,15,17,21H,8,12-14H2,1-4H3,(H,34,36)/t17-,21?,26?/m1/s1	YPUYZHJKGABFEF-XJNIYMOYSA-N	320238	3-[(5-isopropyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 405::US10202369, Example 405::US10472354, Example 405	P2X purinoceptor 2/3	Homo sapiens		 1558							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320238&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397496	384223510							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683612	C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O3S/c1-14-8-29-22(37-14)17-4-16(5-20(6-17)35-13-24-7-19(11-36-24)33(3)12-24)21(34)32-15(2)18-9-30-23(31-10-18)25(26,27)28/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,32,34)/t15-,19?,24?/m1/s1	QZIIXNSQPLEQAW-QOFOLWBBSA-N	320239	3-[(5-methyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 406::US10202369, Example 406::US10472354, Example 406	P2X purinoceptor 2/3	Homo sapiens		 2026							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320239&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397318	384223511							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683614	C[C@@H](NC(=O)c1cc(OCC23CNC(CO2)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O3S/c1-13-7-28-21(36-13)16-3-15(4-19(5-16)34-12-23-6-18(10-35-23)31-11-23)20(33)32-14(2)17-8-29-22(30-9-17)24(25,26)27/h3-5,7-9,14,18,31H,6,10-12H2,1-2H3,(H,32,33)/t14-,18?,23?/m1/s1	NAZJZFLNXXGFCR-IHDUPTFDSA-N	320240	3-(5-Methyl-1,3-thiazol-2-yl)-5-[2-oxa-5-azabicyclo[2.2.1]hept-1-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of 2 Diastereoisomers::US10174016, Example 407::US10202369, Example 407::US10472354, Example 407	P2X purinoceptor 2/3	Homo sapiens		 1681							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320240&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397648	384223512							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683616	CCCN1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2	InChI=1S/C27H30F3N5O3S/c1-4-5-35-14-26(9-21(35)13-38-26)15-37-22-7-18(6-19(8-22)24-31-10-16(2)39-24)23(36)34-17(3)20-11-32-25(33-12-20)27(28,29)30/h6-8,10-12,17,21H,4-5,9,13-15H2,1-3H3,(H,34,36)/t17-,21?,26?/m1/s1	AAPJJGZIWGLKBD-XJNIYMOYSA-N	320241	3-(5-methyl-1,3- thiazol-2-yl)-5-[(5- propyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 408::US10202369, Example 408::US10472354, Example 408	P2X purinoceptor 2/3	Homo sapiens		 1710							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320241&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397789	384223513							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683618	COC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2	InChI=1S/C26H26F3N5O5S/c1-14-8-30-22(40-14)17-4-16(21(35)33-15(2)18-9-31-23(32-10-18)26(27,28)29)5-20(6-17)38-13-25-7-19(11-39-25)34(12-25)24(36)37-3/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,33,35)/t15-,19?,25?/m1/s1	ACUSXDHHFJWBEG-QYRGRQSGSA-N	320242	Methyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a mixture of 2 diastereoisomers::US10174016, Example 409::US10202369, Example 409::US10472354, Example 409	P2X purinoceptor 2/3	Homo sapiens		 976							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320242&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397200	384223514							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683620	CCOC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2	InChI=1S/C27H28F3N5O5S/c1-4-38-25(37)35-13-26(8-20(35)12-40-26)14-39-21-6-17(5-18(7-21)23-31-9-15(2)41-23)22(36)34-16(3)19-10-32-24(33-11-19)27(28,29)30/h5-7,9-11,16,20H,4,8,12-14H2,1-3H3,(H,34,36)/t16-,20?,26?/m1/s1	MVNNYWBQRAUUBD-ORALUJHKSA-N	320243	Ethyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a Mixture of 2 Diastereoisomers::US10174016, Example 410::US10202369, Example 410::US10472354, Example 410	P2X purinoceptor 2/3	Homo sapiens		 906							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320243&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397180	384223515							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683622	CCN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21+/m1/s1	IJXNJADLTIUKEL-IERDGZPVSA-N	320244	3-{[(2S)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 411::US10202369, Example 411::US10472354, Example 411	P2X purinoceptor 2/3	Homo sapiens		 697							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320244&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397533	384223516							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683624	C[C@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m0/s1	OEKUZTDVCYAZBS-HTAPYJJXSA-N	320245	Tert-butyl (2R)-2- {[3-(5-methyl-1,3- thiazol-2-yl)-5- ({(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl]carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 412::US10202369, Example 412	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320245	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320245&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338453	384223517							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683626	C[C@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m0/s1	HRVUBTPQOQIHTK-IFXJQAMLSA-N	320246	3-(5-methyl- 1,3-thiazol-2- yl)-5-[(2R)- morpholin-2- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 413::US10202369, Example 413::US10472354, Example 413	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320246&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397518	384223518							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683628	CCc1cnc(s1)-c1cc(OC[C@@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18+/m1/s1	PAVCMPZQEBSSQV-KDOFPFPSSA-N	320247	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 414::US10202369, Example 414::US10472354, Example 414	P2X purinoceptor 2/3	Homo sapiens		 2272							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320247&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397150	384223519							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683630	CCc1cnc(s1)-c1cc(OC[C@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18-/m1/s1	PAVCMPZQEBSSQV-RDTXWAMCSA-N	320248	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 415::US10202369, Example 415::US10472354, Example 415	P2X purinoceptor 2/3	Homo sapiens		 2177							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320248&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397550	384223520							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683632	C[C@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m0/s1	MROBUJILSMBILX-MGPUTAFESA-N	320249	3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 416::US10202369, Example 416	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320249	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320249&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397764	384223521							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683634	C[C@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m0/s1	MROBUJILSMBILX-YWZLYKJASA-N	320250	3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 417::US10202369, Example 417	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320250	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320250&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397582	384223522							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683636	CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19+/m1/s1	SIFMRPZFMXLARV-BEFAXECRSA-N	322607	3-(5-Ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 418::US10202369, Example 418::US10472354, Example 418	P2X purinoceptor 2/3	Homo sapiens		 1556							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322607	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322607&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397330	384225667							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683638	CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19-/m1/s1	SIFMRPZFMXLARV-DNVCBOLYSA-N	322608	3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 419::US10202369, Example 419::US10472354, Example 419	P2X purinoceptor 2/3	Homo sapiens		 1136							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322608	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322608&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397262	384225668							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683060	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19+/m1/s1	RHVHBKMOULQMJQ-KUHUBIRLSA-N	319963	N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 130::US10202369, Example 130::US10472354, Example 130	P2X purinoceptor 2/3	Homo sapiens		 1349							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319963&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397599	384223243							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683062	C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C24H23N5O2S/c1-14-5-6-20(12-25-14)31-21-8-18(7-19(9-21)24-28-11-16(3)32-24)23(30)29-17(4)22-13-26-15(2)10-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1	PZARJLLATJAKMG-QGZVFWFLSA-N	319964	N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-[(6-methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 131::US10202369, Example 131::US10472354, Example 131	P2X purinoceptor 2/3	Homo sapiens		 730							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319964&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397434	384223244							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683064	CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1	YETTUNLUNMEXML-RUINGEJQSA-N	319965	N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 132::US10202369, Example 132::US10472354, Example 132	P2X purinoceptor 2/3	Homo sapiens		 2051							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319965&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397504	384223245							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683066	Cc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m0/s1	VKRRMZCTKMLCQJ-SFHVURJKSA-N	319966	N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 133::US10202369, Example 133::US10472354, Example 133	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319966&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397536	384223246							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683068	CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1	DLODQDUFIVUCLQ-RUINGEJQSA-N	319967	N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 134::US10202369, Example 134::US10472354, Example 134	P2X purinoceptor 2/3	Homo sapiens		 210							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319967&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397151	384223247							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683070	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18+/m1/s1	KRMAXJMLJAVOGJ-MSOLQXFVSA-N	319968	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 135::US10202369, Example 135::US10472354, Example 270	P2X purinoceptor 2/3	Homo sapiens		 209							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319968&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397422	384223248							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683072	COCCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(C)nc1	InChI=1S/C21H24N4O3S/c1-13-10-24-21(29-13)17-7-16(8-19(9-17)28-6-5-27-4)20(26)25-14(2)18-11-22-15(3)23-12-18/h7-12,14H,5-6H2,1-4H3,(H,25,26)/t14-/m1/s1	NMXUVEDIBFBQMK-CQSZACIVSA-N	319969	3-(2-Methoxyethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 136::US10202369, Example 136::US10472354, Example 136	P2X purinoceptor 2/3	Homo sapiens		 2780							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319969&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397574	384223249							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683074	C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(cn1)C(F)(F)F	InChI=1S/C28H32F3N5O4S/c1-16-13-34-25(41-16)19-10-18(24(37)35-17(2)22-14-33-23(15-32-22)28(29,30)31)11-21(12-19)39-20-6-8-36(9-7-20)26(38)40-27(3,4)5/h10-15,17,20H,6-9H2,1-5H3,(H,35,37)/t17-/m1/s1	MOJZESVRLRZYMR-QGZVFWFLSA-N	346150	US10202369, Example 137::tert-Butyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate	P2X purinoceptor 2/3	Homo sapiens		 328							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346150&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134391357	385452201							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683076	C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-10-28-21(34-13)16-7-15(8-19(9-16)33-18-3-5-27-6-4-18)20(32)31-14(2)17-11-29-22(30-12-17)23(24,25)26/h7-12,14,18,27H,3-6H2,1-2H3,(H,31,32)/t14-/m1/s1	AUEVADIQWKJNQT-CQSZACIVSA-N	319971	3-(5-Methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 138::US10202369, Example 138::US10472354, Example 138	P2X purinoceptor 2/3	Homo sapiens		 559							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319971&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397389	384223251							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683078	C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-11-28-22(35-14)17-8-16(9-20(10-17)34-19-4-6-32(3)7-5-19)21(33)31-15(2)18-12-29-23(30-13-18)24(25,26)27/h8-13,15,19H,4-7H2,1-3H3,(H,31,33)/t15-/m1/s1	BKNIRTNEYAOJDL-OAHLLOKOSA-N	319972	3-[(1-Methylpiperidin-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 139::US10202369, Example 139::US10472354, Example 215	P2X purinoceptor 2/3	Homo sapiens		 962							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319972&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397521	384223252							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683080	CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H30F3N5O2S/c1-15(2)34-7-5-21(6-8-34)36-22-10-18(9-19(11-22)24-30-12-16(3)37-24)23(35)33-17(4)20-13-31-25(32-14-20)26(27,28)29/h9-15,17,21H,5-8H2,1-4H3,(H,33,35)/t17-/m1/s1	JAJQPYKLEVBCIY-QGZVFWFLSA-N	319973	3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 140::US10202369, Example 140::US10472354, Example 140	P2X purinoceptor 2/3	Homo sapiens		 1295							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319973&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397336	384223253							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683082	C[C@@H](NC(=O)c1cc(O[C@@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18-/m1/s1	RNHSPVKPEXJLAD-RDTXWAMCSA-N	319974	3-{[(3R)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 141::US10202369, Example 141::US10472354, Example 141	P2X purinoceptor 2/3	Homo sapiens		 2201							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319974&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397272	384223254							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683084	C[C@@H](NC(=O)c1cc(O[C@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18+/m1/s1	RNHSPVKPEXJLAD-KDOFPFPSSA-N	319975	3-{[(3S)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 142::US10202369, Example 142::US10472354, Example 142	P2X purinoceptor 2/3	Homo sapiens		 222							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319975&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397181	384223255							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683086	C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H22F3N5O2S/c1-12-7-26-20(33-12)15-4-14(5-17(6-15)32-18-10-30(3)11-18)19(31)29-13(2)16-8-27-21(28-9-16)22(23,24)25/h4-9,13,18H,10-11H2,1-3H3,(H,29,31)/t13-/m1/s1	NFRXFSQBXDHWHW-CYBMUJFWSA-N	319976	3-[(1-Methylazetidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 143::US10202369, Example 143::US10472354, Example 143	P2X purinoceptor 2/3	Homo sapiens		 3047							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319976&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397519	384223256							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683088	C[C@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m0/s1	BTRSFHCVZJPJKT-ZDUSSCGKSA-N	319977	3-(5-Methyl-1,3-thiazol-2-yl)-5-(prop-2-yn-1-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 144::US10202369, Example 144::US10472354, Example 144	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319977&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397460	384223257							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683090	C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m0/s1	WGQQHPGXKFPPTQ-AWEZNQCLSA-N	319978	3-(5-Methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 145::US10202369, Example 145::US10472354, Example 145	P2X purinoceptor 2/3	Homo sapiens		 4461							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319978&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397306	384223258							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683092	C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C29H32F3N5O4S/c1-16-11-33-24(42-16)19-6-18(23(38)36-17(2)20-12-34-25(35-13-20)29(30,31)32)7-21(8-19)40-22-9-28(10-22)14-37(15-28)26(39)41-27(3,4)5/h6-8,11-13,17,22H,9-10,14-15H2,1-5H3,(H,36,38)/t17-/m1/s1	GOFUMWOIVIXXIJ-QGZVFWFLSA-N	319979	US10174016, Example 146::US10202369, Example 146::US10472354, Example 146::tert-butyl 6-[3-(5- methyl-1,3- thiazol-2-yl)-5- ({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]-2- azaspiro[3.3]heptane- 2-carboxylate	P2X purinoceptor 2/3	Homo sapiens		 159							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319979&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397340	384223259							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683094	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(cn1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-8-28-21(33-12)15-5-14(6-17(7-15)32-16-3-4-31-11-16)20(30)29-13(2)18-9-27-19(10-26-18)22(23,24)25/h5-10,13,16H,3-4,11H2,1-2H3,(H,29,30)/t13-,16-/m1/s1	DVMONFUPUPPMFW-CZUORRHYSA-N	319980	3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [5- (trifluoromethyl) pyrazin-2- yl]ethyl}benzamide::US10174016, Example 147::US10202369, Example 147::US10472354, Example 147	P2X purinoceptor 2/3	Homo sapiens		 132							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319980&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397189	384223260							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683096	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C22H20F3N3O3S/c1-12-8-27-21(32-12)16-5-15(6-17(7-16)31-18-10-30-11-18)20(29)28-13(2)14-3-4-19(26-9-14)22(23,24)25/h3-9,13,18H,10-11H2,1-2H3,(H,28,29)/t13-/m1/s1	NAXHTXVAPBZYNR-CYBMUJFWSA-N	319981	3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 148::US10202369, Example 148::US10472354, Example 148	P2X purinoceptor 2/3	Homo sapiens		 794							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319981&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397138	384223261							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683098	C[C@@H](NC(=O)c1cc(OC23CCN(CC2)CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-15-12-29-22(36-15)18-9-17(10-20(11-18)35-24-3-6-33(7-4-24)8-5-24)21(34)32-16(2)19-13-30-23(31-14-19)25(26,27)28/h9-14,16H,3-8H2,1-2H3,(H,32,34)/t16-/m1/s1	RAGSAJSSGMANHP-MRXNPFEDSA-N	319982	3-(1- azabicyclo[2.2.2] oct-4-yloxy)-5-(5- methyl-1,3- thiazol-3-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 149::US10202369, Example 149::US10472354, Example 149	P2X purinoceptor 2/3	Homo sapiens		 936							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319982	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319982&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397715	384223262							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683100	C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(C)=O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O3S/c1-14-11-29-23(37-14)18-8-17(9-21(10-18)36-20-4-6-33(7-5-20)16(3)34)22(35)32-15(2)19-12-30-24(31-13-19)25(26,27)28/h8-13,15,20H,4-7H2,1-3H3,(H,32,35)/t15-/m1/s1	ISMQQTCWBNBFKY-OAHLLOKOSA-N	319983	3-[(1- acetylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 150::US10202369, Example 150::US10472354, Example 150	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319983&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397215	384223263							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683102	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F	InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17+/m1/s1	AUVRCFBFFFYNAV-DYVFJYSZSA-N	319984	N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 151::US10202369, Example 151::US10472354, Example 151	P2X purinoceptor 2/3	Homo sapiens		 333							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319984&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397480	384223264							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683104	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F	InChI=1S/C21H20F2N4O3S/c1-11-6-26-21(31-11)14-3-13(4-16(5-14)30-17-9-29-10-17)20(28)27-12(2)15-7-24-19(18(22)23)25-8-15/h3-8,12,17-18H,9-10H2,1-2H3,(H,27,28)/t12-/m1/s1	YTKWIWSPGJOVJL-GFCCVEGCSA-N	319985	N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 152::US10202369, Example 152::US10472354, Example 152	P2X purinoceptor 2/3	Homo sapiens		 523							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319985&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397528	384223265							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683106	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F	InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17-/m1/s1	AUVRCFBFFFYNAV-CXAGYDPISA-N	319986	N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 153::US10202369, Example 153::US10472354, Example 153	P2X purinoceptor 2/3	Homo sapiens		 304							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319986	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319986&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397665	384223266							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683108	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F	InChI=1S/C23H24F2N4O3S/c1-13-10-28-23(33-13)16-7-15(8-19(9-16)32-18-3-5-31-6-4-18)22(30)29-14(2)17-11-26-21(20(24)25)27-12-17/h7-12,14,18,20H,3-6H2,1-2H3,(H,29,30)/t14-/m1/s1	RQWRZCMIWXGQJP-CQSZACIVSA-N	319987	N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 154::US10202369, Example 154::US10472354, Example 154	P2X purinoceptor 2/3	Homo sapiens		 130							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319987	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319987&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397560	384223267							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683110	C[C@@H](NC(=O)c1cc(O[C@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1	DNVWWBHMIGZIMX-BEFAXECRSA-N	319988	3-{[(3S)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 155::US10174016, Example 221::US10202369, Example 155::US10472354, Example 155	P2X purinoceptor 2/3	Homo sapiens		 2267							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319988&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397794	384223268							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683112	C[C@@H](NC(=O)c1cc(OC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-7-26-19(33-12)15-4-14(5-17(6-15)32-21(3)10-31-11-21)18(30)29-13(2)16-8-27-20(28-9-16)22(23,24)25/h4-9,13H,10-11H2,1-3H3,(H,29,30)/t13-/m1/s1	OYDLDEWAXBGGBJ-CYBMUJFWSA-N	319989	3-[(3- methyloxetan-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 156::US10202369, Example 156::US10472354, Example 156	P2X purinoceptor 2/3	Homo sapiens		 163							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319989&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397627	384223269							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683114	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C23H22F3N3O3S/c1-13-10-28-22(33-13)17-7-16(8-19(9-17)32-18-5-6-31-12-18)21(30)29-14(2)15-3-4-20(27-11-15)23(24,25)26/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,29,30)/t14-,18-/m1/s1	RHAXZNLWUJRHEA-RDTXWAMCSA-N	319990	3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 157::US10202369, Example 157::US10472354, Example 157	P2X purinoceptor 2/3	Homo sapiens		 534							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319990&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397372	384223270							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683116	C[C@@H](NC(=O)c1cc(O[C@@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1	DNVWWBHMIGZIMX-DNVCBOLYSA-N	319991	3-{[(3R)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 158::US10174016, Example 220::US10202369, Example 158::US10472354, Example 158	P2X purinoceptor 2/3	Homo sapiens		 1939							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319991&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397414	384223271							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683118	C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H20F3N7O2S/c1-13-8-27-20(35-13)16-5-15(6-18(7-16)34-4-3-32-12-26-11-30-32)19(33)31-14(2)17-9-28-21(29-10-17)22(23,24)25/h5-12,14H,3-4H2,1-2H3,(H,31,33)/t14-/m1/s1	HYNLHPVSAUUUKN-CQSZACIVSA-N	319992	3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 159::US10202369, Example 159::US10472354, Example 159	P2X purinoceptor 2/3	Homo sapiens		 1233							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319992&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397126	384223272							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683120	C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C23H21F3N6O2S/c1-14-10-29-22(35-14)18-7-17(8-19(9-18)34-6-5-32-13-27-12-30-32)21(33)31-15(2)16-3-4-20(28-11-16)23(24,25)26/h3-4,7-13,15H,5-6H2,1-2H3,(H,31,33)/t15-/m1/s1	ZEDPNXXTTLJFPM-OAHLLOKOSA-N	319993	3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 160::US10202369, Example 160::US10472354, Example 160	P2X purinoceptor 2/3	Homo sapiens		 1007							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319993&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397838	384223273							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683122	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C21H19F3N4O3S/c1-11-8-25-20(32-11)14-5-13(6-15(7-14)31-16-9-30-10-16)19(29)26-12(2)17-3-4-18(28-27-17)21(22,23)24/h3-8,12,16H,9-10H2,1-2H3,(H,26,29)/t12-/m1/s1	GINDYDBHFAVPIL-GFCCVEGCSA-N	319994	3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 161::US10202369, Example 161::US10472354, Example 161	P2X purinoceptor 2/3	Homo sapiens		 632							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319994&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397757	384223274							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683124	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1	FSGDRFBLPAILDE-IYXRBSQSSA-N	319995	3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338	P2X purinoceptor 2/3	Homo sapiens		 74.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397269	384223275							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683126	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m0/s1	FSGDRFBLPAILDE-HSBZDZAISA-N	319996	US10174016, Example 163::US10202369, Example 340::US10472354, Example 162	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319996&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134328174	384223276							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683128	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F	InChI=1S/C22H21F2N3O3S/c1-12-8-26-22(31-12)16-5-15(6-17(7-16)30-18-10-29-11-18)21(28)27-13(2)14-3-4-19(20(23)24)25-9-14/h3-9,13,18,20H,10-11H2,1-2H3,(H,27,28)/t13-/m1/s1	VIFFUASYGYMCSF-CYBMUJFWSA-N	319997	N-{[(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 164::US10202369, Example 164::US10472354, Example 164	P2X purinoceptor 2/3	Homo sapiens		 1107							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319997	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319997&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397252	384223277							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683130	C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H](C2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-13-10-28-22(35-13)16-5-15(6-19(7-16)34-20-8-18(9-20)32(3)4)21(33)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h5-7,10-12,14,18,20H,8-9H2,1-4H3,(H,31,33)/t14-,18-,20-/m1/s1	AGHYBRFMKRJHNY-LXGCGDOSSA-N	319998	3-{[trans-3- (dimethylamino) cyclobutyl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 165::US10202369, Example 165::US10472354, Example 165	P2X purinoceptor 2/3	Homo sapiens		 1923							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319998&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397549	384223278							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683132	Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F	InChI=1S/C21H19F3N4O3S/c1-12-7-26-19(32-12)15-4-14(5-17(6-15)31-16-2-3-30-11-16)18(29)25-8-13-9-27-20(28-10-13)21(22,23)24/h4-7,9-10,16H,2-3,8,11H2,1H3,(H,25,29)/t16-/m1/s1	MLKRPMMAEMGGNI-MRXNPFEDSA-N	319999	3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 166::US10202369, Example 166::US10472354, Example 166	P2X purinoceptor 2/3	Homo sapiens		 461							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319999&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397360	384223279							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683134	Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F	InChI=1S/C20H17F3N4O3S/c1-11-5-25-18(31-11)14-2-13(3-15(4-14)30-16-9-29-10-16)17(28)24-6-12-7-26-19(27-8-12)20(21,22)23/h2-5,7-8,16H,6,9-10H2,1H3,(H,24,28)	AWMOXCQCRBHEDH-UHFFFAOYSA-N	320000	3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 167::US10202369, Example 167::US10472354, Example 167	P2X purinoceptor 2/3	Homo sapiens		 893							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320000	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320000&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397228	384223280							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683136	C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21+/m1/s1	XGNFOBIXAZWFEF-VFNWGFHPSA-N	320001	3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 168::US10202369, Example 168::US10472354, Example 168	P2X purinoceptor 2/3	Homo sapiens		 1600							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320001&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397190	384223281							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683138	CCc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-3-18-9-26-20(33-18)14-4-13(5-16(6-14)32-17-10-31-11-17)19(30)29-12(2)15-7-27-21(28-8-15)22(23,24)25/h4-9,12,17H,3,10-11H2,1-2H3,(H,29,30)/t12-/m1/s1	KJLXSAGNAKDMHX-GFCCVEGCSA-N	320002	3-(5-ethyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 169::US10202369, Example 169::US10472354, Example 169	P2X purinoceptor 2/3	Homo sapiens		 70.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320002&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397192	384223282							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683140	C[C@@H](NC(=O)c1cc(Oc2ccc(C)nn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H19F3N6O2S/c1-12-4-5-19(32-31-12)34-18-7-15(6-16(8-18)21-27-9-13(2)35-21)20(33)30-14(3)17-10-28-22(29-11-17)23(24,25)26/h4-11,14H,1-3H3,(H,30,33)/t14-/m1/s1	YBWKZVABJNKBEG-CQSZACIVSA-N	320003	3-[(6- methylpyridazin-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 170::US10202369, Example 170::US10472354, Example 170	P2X purinoceptor 2/3	Homo sapiens		 2020							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320003&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397298	384223283							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683142	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F	InChI=1S/C23H23F2N3O3S/c1-13-10-27-23(32-13)17-7-16(8-19(9-17)31-18-5-6-30-12-18)22(29)28-14(2)15-3-4-20(21(24)25)26-11-15/h3-4,7-11,14,18,21H,5-6,12H2,1-2H3,(H,28,29)/t14-,18-/m1/s1	UIFKRKFOSZCXTP-RDTXWAMCSA-N	320004	N-{(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 171::US10202369, Example 171::US10472354, Example 171	P2X purinoceptor 2/3	Homo sapiens		 573							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320004&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397544	384223284							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683144	C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22+/m1/s1	BTZKHRISYBAOIH-ZHRRBRCNSA-N	320005	3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 172::US10202369, Example 172::US10472354, Example 172	P2X purinoceptor 2/3	Homo sapiens		 2107							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320005&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397643	384223285							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683146	CCc1cnc(s1)-c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22-/m1/s1	SVMXJSAEFPTNIN-IVZQSRNASA-N	320006	3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 173::US10202369, Example 173::US10472354, Example 173	P2X purinoceptor 2/3	Homo sapiens		 311							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320006&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397592	384223286							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683148	CCc1cnc(s1)-c1cc(O[C@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22+/m1/s1	SVMXJSAEFPTNIN-QRQCRPRQSA-N	320007	3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 174::US10202369, Example 174::US10472354, Example 174	P2X purinoceptor 2/3	Homo sapiens		 790							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320007&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397479	384223287							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683150	C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22-/m1/s1	BTZKHRISYBAOIH-OPAMFIHVSA-N	320008	3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 175::US10202369, Example 175::US10472354, Example 175	P2X purinoceptor 2/3	Homo sapiens		 1274							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320008&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397558	384223288							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683152	C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C22H18F3N5O2S2/c1-11-9-27-20(33-11)16-6-15(7-17(8-16)32-21-30-29-13(3)34-21)19(31)28-12(2)14-4-5-18(26-10-14)22(23,24)25/h4-10,12H,1-3H3,(H,28,31)/t12-/m1/s1	IWXLKQRNUPTLAV-GFCCVEGCSA-N	320009	3-[(5-methyl- 1,3,4-thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 176::US10202369, Example 176::US10472354, Example 176	P2X purinoceptor 2/3	Homo sapiens		 607							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320009&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397692	384223289							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683154	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20-/m1/s1	LZEBVIBIWJOALL-FOIQADDNSA-N	320010	3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 177::US10202369, Example 177::US10472354, Example 177	P2X purinoceptor 2/3	Homo sapiens		 887							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320010&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397515	384223290							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683156	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19-/m1/s1	NQEFGEXCJWOEFF-AUUYWEPGSA-N	320011	3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 178::US10202369, Example 178::US10472354, Example 178	P2X purinoceptor 2/3	Homo sapiens		 1880							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320011&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397229	384223291							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683158	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18-/m1/s1	PZDPWIRLHUGUOG-RDTXWAMCSA-N	320012	3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl]ethyl} benzamide::US10174016, Example 179::US10202369, Example 179::US10472354, Example 179	P2X purinoceptor 2/3	Homo sapiens		 703							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320012&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397371	384223292							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683160	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20+/m1/s1	LZEBVIBIWJOALL-QRWLVFNGSA-N	320013	3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3-thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl)pyridin- 3-yl]ethyl}benzamide::US10174016, Example 180::US10202369, Example 180::US10472354, Example 180	P2X purinoceptor 2/3	Homo sapiens		 1399							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320013&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397137	384223293							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683162	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19+/m1/s1	NQEFGEXCJWOEFF-KUHUBIRLSA-N	320014	3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 181::US10202369, Example 181::US10472354, Example 181	P2X purinoceptor 2/3	Homo sapiens		 1181							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320014&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397128	384223294							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683164	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18+/m1/s1	PZDPWIRLHUGUOG-KDOFPFPSSA-N	320015	3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 182::US10202369, Example 182::US10472354, Example 182	P2X purinoceptor 2/3	Homo sapiens		 1943							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320015&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397642	384223295							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683166	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1	LMHZXBDHIYABCN-IYXRBSQSSA-N	320016	Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231	P2X purinoceptor 2/3	Homo sapiens		 398							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397175	384223296							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683168	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1	QTLJKKFADUZLKR-VOMCLLRMSA-N	320017	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188	P2X purinoceptor 2/3	Homo sapiens		 128							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397494	384223297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683170	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1	QTLJKKFADUZLKR-VOMCLLRMSA-N	320017	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188	P2X purinoceptor 2/3	Homo sapiens		 123							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397494	384223297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683172	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F	InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1	HTVWJAQZHONFAU-PNESKVBLSA-N	320019	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189	P2X purinoceptor 2/3	Homo sapiens		 247							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397322	384223298							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683174	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1	QTLJKKFADUZLKR-VOMCLLRMSA-N	320017	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188	P2X purinoceptor 2/3	Homo sapiens		 218							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397494	384223297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683176	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1	QTLJKKFADUZLKR-VOMCLLRMSA-N	320017	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188	P2X purinoceptor 2/3	Homo sapiens		 164							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397494	384223297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683178	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F	InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1	HTVWJAQZHONFAU-PNESKVBLSA-N	320019	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189	P2X purinoceptor 2/3	Homo sapiens		 258							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397322	384223298							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683180	C[C@@H](NC(=O)c1cc(OC2CCCN(C2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O4S/c1-16-12-32-24(41-16)19-9-18(23(37)35-17(2)20-13-33-25(34-14-20)28(29,30)31)10-22(11-19)39-21-7-6-8-36(15-21)26(38)40-27(3,4)5/h9-14,17,21H,6-8,15H2,1-5H3,(H,35,37)/t17-,21?/m1/s1	GMVSECYUKAWWNE-OQHSHRKDSA-N	320023	US10174016, Example 190::US10202369, Example 190::US10472354, Example 190::tert-Butyl (3R)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate, as a mixture of diastereoisomers	P2X purinoceptor 2/3	Homo sapiens		 207							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320023&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338447	384223299							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683182	CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C22H22N4O2S/c1-5-6-9-28-19-11-17(10-18(12-19)22-23-13-15(3)29-22)21(27)24-16(4)20-8-7-14(2)25-26-20/h7-8,10-13,16H,9H2,1-4H3,(H,24,27)/t16-/m1/s1	WEKOJPFCJMIPGB-MRXNPFEDSA-N	320024	3-(but-2-yn-1- yloxy)-N-[(1R)- 1-(6- methylpyridazin- 3- yl)ethyl]-5- (5-methyl- 1,3-thiazol-2-yl) benzamide::US10174016, Example 191::US10202369, Example 191::US10472354, Example 191	P2X purinoceptor 2/3	Homo sapiens		 364							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320024	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320024&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397657	384223300							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683184	C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21-/m1/s1	XGNFOBIXAZWFEF-QVKFZJNVSA-N	320025	3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl} benzamide::US10174016, Example 192::US10202369, Example 192::US10472354, Example 192	P2X purinoceptor 2/3	Homo sapiens		 910							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320025&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397263	384223301							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683186	C[C@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m0/s1	CAKLWYTTWVXMCY-JTQLQIEISA-N	320027	US10174016, Example 194::US10202369, Example 193::US10472354, Example 193	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320027	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320027&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374897	384223303							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683188	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m1/s1	CAKLWYTTWVXMCY-SNVBAGLBSA-N	320026	3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 193::US10202369, Example 194::US10472354, Example 194	P2X purinoceptor 2/3	Homo sapiens		 579							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320026	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320026&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374896	384223302							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683190	C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m0/s1	NWTVSPCFEGLAFO-LBPRGKRZSA-N	320029	US10174016, Example 196::US10202369, Example 195::US10472354, Example 195	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320029&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374899	384223305							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683192	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m1/s1	NWTVSPCFEGLAFO-GFCCVEGCSA-N	320028	3-(5-methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 195::US10202369, Example 196::US10472354, Example 196	P2X purinoceptor 2/3	Homo sapiens		 293							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320028&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374898	384223304							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683194	C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m0/s1	SHLRNWXFYHGFLL-SMDDNHRTSA-N	320031	US10174016, Example 198::US10202369, Example 197::US10472354, Example 197	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320031	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320031&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374900	384223307							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683196	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m1/s1	SHLRNWXFYHGFLL-BXUZGUMPSA-N	320030	3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 197::US10202369, Example 198::US10472354, Example 198	P2X purinoceptor 2/3	Homo sapiens		 245							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320030&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397585	384223306							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683198	C[C@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m0/s1	SHLRNWXFYHGFLL-FZMZJTMJSA-N	320033	US10174016, Example 200::US10202369, Example 199::US10472354, Example 199	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320033&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374901	384223309							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683200	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m1/s1	SHLRNWXFYHGFLL-RISCZKNCSA-N	320032	3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 199::US10202369, Example 200::US10472354, Example 200	P2X purinoceptor 2/3	Homo sapiens		 546							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320032	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320032&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397243	384223308							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683202	C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-12-28-22(34-13)16-9-15(10-18(11-16)33-17-5-7-27-8-6-17)21(32)29-14(2)19-3-4-20(31-30-19)23(24,25)26/h3-4,9-12,14,17,27H,5-8H2,1-2H3,(H,29,32)/t14-/m1/s1	JTGZQMREWDOCMX-CQSZACIVSA-N	320034	3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 201::US10202369, Example 201::US10472354, Example 201	P2X purinoceptor 2/3	Homo sapiens		 1854							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320034&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397404	384223310							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683204	C[C@@H](NC(=O)c1cc(OC2CC3(CNC3)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O2S/c1-13-8-29-21(35-13)16-3-15(4-18(5-16)34-19-6-23(7-19)11-28-12-23)20(33)32-14(2)17-9-30-22(31-10-17)24(25,26)27/h3-5,8-10,14,19,28H,6-7,11-12H2,1-2H3,(H,32,33)/t14-/m1/s1	KMHSWHWDZALJOK-CQSZACIVSA-N	320035	3-(2- azaspiro[3.3] hept- 6-yloxy)-5-(5- methyl-1,3- thiazol-2- yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 202::US10202369, Example 202::US10472354, Example 202	P2X purinoceptor 2/3	Homo sapiens		 1710							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320035	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320035&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397731	384223311							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683206	C[C@@H](NC(=O)c1cc(O[C@H]2CCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H22F3N5O2S/c1-12-8-27-20(33-12)15-5-14(6-18(7-15)32-17-3-4-26-11-17)19(31)30-13(2)16-9-28-21(29-10-16)22(23,24)25/h5-10,13,17,26H,3-4,11H2,1-2H3,(H,30,31)/t13-,17+/m1/s1	IUOVXWVSORDTAX-DYVFJYSZSA-N	320036	3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- pyrrolidin-3- yloxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 203::US10202369, Example 203::US10472354, Example 203	P2X purinoceptor 2/3	Homo sapiens		 1561							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320036&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397829	384223312							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683208	C[C@@H](NC(=O)c1cc(OC2CCNCC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F4N5O2S/c1-12-8-29-21(35-12)15-5-14(6-17(7-15)34-19-3-4-28-11-18(19)24)20(33)32-13(2)16-9-30-22(31-10-16)23(25,26)27/h5-10,13,18-19,28H,3-4,11H2,1-2H3,(H,32,33)/t13-,18?,19?/m1/s1	IVYMHMMQRKFONZ-XYJCDUHRSA-N	320037	3-{[3- fluoropiperidin- 4-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of cis isomers::US10174016, Example 204::US10202369, Example 204::US10472354, Example 204	P2X purinoceptor 2/3	Homo sapiens		 82.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320037&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397537	384223313							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683210	C[C@@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m1/s1	YIMSHVDFMHXVTO-IKJXHCRLSA-N	322394	3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 205::US10202369, Example 205::US10472354, Example 206	P2X purinoceptor 2/3	Homo sapiens		 272							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322394	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322394&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397478	384225457							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683212	C[C@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m0/s1	YIMSHVDFMHXVTO-PIVQAISJSA-N	322395	US10183937, Example 206::US10202369, Example 206::US10472354, Example 205	P2X purinoceptor 2/3	Homo sapiens		 1676							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322395&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375407	384225458							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683214	C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1	RLIMWYRKEDYMPQ-UYCDIGJJSA-N	322396	3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 207::US10202369, Example 207::US10472354, Example 208	P2X purinoceptor 2/3	Homo sapiens		 87.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322396	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322396&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397615	384225459							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683216	C[C@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m0/s1	RLIMWYRKEDYMPQ-LJSZUPLFSA-N	322397	US10183937, Example 208::US10202369, Example 208::US10472354, Example 207	P2X purinoceptor 2/3	Homo sapiens		 89.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322397	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322397&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375408	384225460							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683218	C[C@@H](NC(=O)c1cc(OC2CC3CC2CN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-13-9-29-23(36-13)16-4-15(6-20(7-16)35-21-8-19-5-17(21)12-33(19)3)22(34)32-14(2)18-10-30-24(31-11-18)25(26,27)28/h4,6-7,9-11,14,17,19,21H,5,8,12H2,1-3H3,(H,32,34)/t14-,17?,19?,21?/m1/s1	BQHHMEMNTIGDMM-LXOQGKBISA-N	320042	3-{[2-methyl-2-azabicyclo[2.2.1]hept-5-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 209::US10202369, Example 209::US10472354, Example 209	P2X purinoceptor 2/3	Homo sapiens		 1470							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320042&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397807	384223318							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683220	C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-13-28-23(35-14)17-10-16(11-19(12-17)34-18-6-8-32(3)9-7-18)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,10-13,15,18H,6-9H2,1-3H3,(H,29,33)/t15-/m1/s1	HKVPHDDZBSOGJS-OAHLLOKOSA-N	320043	3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 210::US10202369, Example 210::US10472354, Example 210	P2X purinoceptor 2/3	Homo sapiens		 1012							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320043	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320043&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397346	384223319							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683222	C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H22F3N5O2S/c1-12-9-26-21(33-12)15-6-14(7-16(8-15)32-17-10-30(3)11-17)20(31)27-13(2)18-4-5-19(29-28-18)22(23,24)25/h4-9,13,17H,10-11H2,1-3H3,(H,27,31)/t13-/m1/s1	IRYKBWGBPIOTOU-CYBMUJFWSA-N	320044	3-[(1- methylazetidin- 3-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 211::US10202369, Example 211::US10472354, Example 211	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320044	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320044&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397301	384223320							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683224	C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F4N5O2S/c1-13-9-29-22(36-13)16-6-15(7-18(8-16)35-20-4-5-33(3)12-19(20)25)21(34)32-14(2)17-10-30-23(31-11-17)24(26,27)28/h6-11,14,19-20H,4-5,12H2,1-3H3,(H,32,34)/t14-,19?,20?/m1/s1	XFFHESNTQMKRAI-WPUWVODUSA-N	320045	3-[(3-fluoro-1- methylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a single unknown isomer::US10174016, Example 212::US10202369, Example 212::US10472354, Example 212	P2X purinoceptor 2/3	Homo sapiens		 46.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320045&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397317	384223321							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683226	C[C@@H](NC(=O)c1cc(OCC2(CC2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)34-13-23(5-6-23)32(3)4)20(33)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,5-6,13H2,1-4H3,(H,31,33)/t15-/m1/s1	GWFQILAPUSJPLG-OAHLLOKOSA-N	320046	3-{[1- (dimethylamino) cyclopropyl] methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 213::US10202369, Example 213::US10472354, Example 213	P2X purinoceptor 2/3	Homo sapiens		 81.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320046&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397636	384223322							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683228	C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-14-9-29-22(36-14)17-4-16(5-19(6-17)35-20-7-24(8-20)12-33(3)13-24)21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28/h4-6,9-11,15,20H,7-8,12-13H2,1-3H3,(H,32,34)/t15-/m1/s1	HKONVGJPBICXCZ-OAHLLOKOSA-N	320047	3-[(2-methyl-2- azaspiro [3.3]hept- 6-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 214::US10202369, Example 214::US10472354, Example 214	P2X purinoceptor 2/3	Homo sapiens		 3392							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320047&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397792	384223323							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683230	C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F	InChI=1S/C24H27F2N5O2S/c1-14-11-29-24(34-14)17-8-16(9-20(10-17)33-19-4-6-31(3)7-5-19)23(32)30-15(2)18-12-27-22(21(25)26)28-13-18/h8-13,15,19,21H,4-7H2,1-3H3,(H,30,32)/t15-/m1/s1	XUPWDJXPNRZNKL-OAHLLOKOSA-N	320048	N-{[(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 215::US10202369, Example 215	P2X purinoceptor 2/3	Homo sapiens		 992							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320048	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320048&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397133	384223324							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683232	C[C@@H](NC(=O)c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22+/m1/s1	BLUSEIUVKSVVTE-DZUANBCISA-N	320049	3-{[(3-endo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 216::US10202369, Example 216::US10472354, Example 216	P2X purinoceptor 2/3	Homo sapiens		 928							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320049&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397314	384223325							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683234	C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22-/m1/s1	BLUSEIUVKSVVTE-BWKKGPAXSA-N	320050	3-{[(3-exo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}- 5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 217::US10202369, Example 217::US10472354, Example 217	P2X purinoceptor 2/3	Homo sapiens		 1750							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320050&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397314	384223326							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683236	C[C@@H](NC(=O)c1cc(O[C@@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21-,22-/m1/s1	FEZSJTOXTJNSGQ-WWGKXEARSA-N	320051	3-{[(4aS,7R, 7aR)-4- methyloctahydro- cyclopenta [b][1,4] oxazin-7-yl] oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 218::US10202369, Example 218::US10472354, Example 218	P2X purinoceptor 2/3	Homo sapiens		 281							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320051	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320051&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397834	384223327							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683238	C[C@@H](NC(=O)c1cc(O[C@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21+,22-/m1/s1	FEZSJTOXTJNSGQ-NSEXGNSCSA-N	320052	3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta[b] [1,4]oxazin- 7-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 219::US10202369, Example 219::US10472354, Example 219	P2X purinoceptor 2/3	Homo sapiens		 199							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320052&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397597	384223328							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683240	C[C@@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m1/s1	DNVWWBHMIGZIMX-NYRJJRHWSA-N	322409	3-[(1-methylpiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 220::US10202369, Example 220::US10472354, Example 221	P2X purinoceptor 2/3	Homo sapiens		 2502							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322409&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397678	384225471							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683242	C[C@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m0/s1	DNVWWBHMIGZIMX-FUKCDUGKSA-N	322410	US10183937, Example 221::US10202369, Example 221::US10472354, Example 220	P2X purinoceptor 2/3	Homo sapiens		 1358							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322410	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322410&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375409	384225472							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683244	C[C@@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m1/s1	ALJCLRFXPKVCLC-FHTBDLFWSA-N	322411	3-(5-methyl-1,3-thiazol-2-yl)-5-{[1-methyl-2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 222::US10202369, Example 222::US10472354, Example 223	P2X purinoceptor 2/3	Homo sapiens		 108							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322411	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322411&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397819	384225473							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683246	C[C@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m0/s1	ALJCLRFXPKVCLC-KLOIUYPJSA-N	322412	US10183937, Example 223::US10202369, Example 223::US10472354, Example 222	P2X purinoceptor 2/3	Homo sapiens		 109							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322412	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322412&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375410	384225474							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683248	CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C26H30F3N5O2S/c1-15(2)34-9-7-20(8-10-34)36-21-12-18(11-19(13-21)25-30-14-16(3)37-25)24(35)31-17(4)22-5-6-23(33-32-22)26(27,28)29/h5-6,11-15,17,20H,7-10H2,1-4H3,(H,31,35)/t17-/m1/s1	KRNISEGUXIGIEE-QGZVFWFLSA-N	320057	3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 224::US10202369, Example 224::US10472354, Example 224	P2X purinoceptor 2/3	Homo sapiens		 569							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320057&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397429	384223331							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683250	CC(C)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H28F3N5O2S/c1-14(2)33-6-5-20(13-33)35-21-8-17(7-18(9-21)23-29-10-15(3)36-23)22(34)32-16(4)19-11-30-24(31-12-19)25(26,27)28/h7-12,14,16,20H,5-6,13H2,1-4H3,(H,32,34)/t16-,20+/m1/s1	AIBFTYSUMUVEOU-UZLBHIALSA-N	320058	3-(5-methyl- 1,3-thiazol- 2-yl)-5- {[(3S)-1- (propan-2- yl)pyrrolidin- 3-yl]oxy}-N- {(1R)-1- [2-(trifluoro- methyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 225::US10202369, Example 225::US10472354, Example 225	P2X purinoceptor 2/3	Homo sapiens		 1145							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320058&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397786	384223332							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683252	COC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O4S/c1-14-11-29-22(38-14)17-8-16(9-20(10-17)37-19-4-6-33(7-5-19)24(35)36-3)21(34)32-15(2)18-12-30-23(31-13-18)25(26,27)28/h8-13,15,19H,4-7H2,1-3H3,(H,32,34)/t15-/m1/s1	XKGQQPBORAHPPR-OAHLLOKOSA-N	320059	Methyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 226::US10202369, Example 226::US10472354, Example 226	P2X purinoceptor 2/3	Homo sapiens		 59.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320059	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320059&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397135	384223333							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683254	CCOC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O4S/c1-4-37-25(36)34-7-5-20(6-8-34)38-21-10-17(9-18(11-21)23-30-12-15(2)39-23)22(35)33-16(3)19-13-31-24(32-14-19)26(27,28)29/h9-14,16,20H,4-8H2,1-3H3,(H,33,35)/t16-/m1/s1	VLNWCOYPKWPZPZ-MRXNPFEDSA-N	320060	Ethyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 227::US10202369, Example 227::US10472354, Example 227	P2X purinoceptor 2/3	Homo sapiens		 161							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320060&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397225	384223334							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683256	CCOC(=O)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O4S/c1-4-36-24(35)33-6-5-19(13-33)37-20-8-16(7-17(9-20)22-29-10-14(2)38-22)21(34)32-15(3)18-11-30-23(31-12-18)25(26,27)28/h7-12,15,19H,4-6,13H2,1-3H3,(H,32,34)/t15-,19+/m1/s1	ZKABVOKJBCLEBM-BEFAXECRSA-N	320061	Ethyl (3S)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]pyrrolidine-1-carboxylate::US10174016, Example 228::US10202369, Example 228::US10472354, Example 228	P2X purinoceptor 2/3	Homo sapiens		 54.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320061	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320061&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338446	384223335							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683258	CC(C)N1CC(C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-13(2)32-11-20(12-32)34-19-6-16(5-17(7-19)22-28-8-14(3)35-22)21(33)31-15(4)18-9-29-23(30-10-18)24(25,26)27/h5-10,13,15,20H,11-12H2,1-4H3,(H,31,33)/t15-/m1/s1	ZGCTZBYNIOVVEC-OAHLLOKOSA-N	320062	3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)azetidin-3-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 229::US10202369, Example 229::US10472354, Example 229	P2X purinoceptor 2/3	Homo sapiens		 2276							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320062	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320062&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397633	384223336							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683260	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1	LMHZXBDHIYABCN-IYXRBSQSSA-N	320016	Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231	P2X purinoceptor 2/3	Homo sapiens		 209							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397175	384223296							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683262	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m0/s1	LMHZXBDHIYABCN-HSBZDZAISA-N	322420	US10183937, Example 231::US10202369, Example 231::US10472354, Example 230	P2X purinoceptor 2/3	Homo sapiens		 706							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322420	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322420&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375411	384225482							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683264	C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O4S2/c1-13-10-27-21(35-13)16-7-15(8-19(9-16)34-18-3-5-36(32,33)6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1	JTWSIDWRGZSZAA-CQSZACIVSA-N	320065	3-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 232::US10202369, Example 232::US10472354, Example 232	P2X purinoceptor 2/3	Homo sapiens		 759							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320065	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320065&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397851	384223339							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683266	C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C24H24F3N3O4S2/c1-14-12-29-23(35-14)18-9-17(10-20(11-18)34-19-5-7-36(32,33)8-6-19)22(31)30-15(2)16-3-4-21(28-13-16)24(25,26)27/h3-4,9-13,15,19H,5-8H2,1-2H3,(H,30,31)/t15-/m1/s1	BRFDVYQZWOBZCT-OAHLLOKOSA-N	320066	3-[(1,1- dioxidotetrahydro- 2H-thiopyran-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 233::US10202369, Example 233::US10472354, Example 233	P2X purinoceptor 2/3	Homo sapiens		 753							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320066	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320066&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397139	384223340							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683268	CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-13-27-24(32-21)18-9-17(10-20(11-18)31-19-5-7-30-8-6-19)23(29)28-16(3)22-14-25-15(2)12-26-22/h9-14,16,19H,4-8H2,1-3H3,(H,28,29)/t16-/m1/s1	DYONOLZVTXITOM-MRXNPFEDSA-N	320067	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 234::US10202369, Example 234::US10472354, Example 234	P2X purinoceptor 2/3	Homo sapiens		 152							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320067	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320067&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397540	384223341							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683270	CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-3-21-14-25-23(31-21)17-10-16(11-20(12-17)30-19-6-8-29-9-7-19)22(28)24-13-18-5-4-15(2)26-27-18/h4-5,10-12,14,19H,3,6-9,13H2,1-2H3,(H,24,28)	BZFPOECMUNEZDH-UHFFFAOYSA-N	320068	3-(5-ethyl-1,3- thiazol-2-yl)-N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 235::US10202369, Example 235::US10472354, Example 235	P2X purinoceptor 2/3	Homo sapiens		 70.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320068	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320068&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397197	384223342							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683272	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-13-28-23(14-27-16)17(2)30-25(31)19-10-20(26-29-15-24(34-26)18-4-3-5-18)12-22(11-19)33-21-6-8-32-9-7-21/h10-15,17-18,21H,3-9H2,1-2H3,(H,30,31)/t17-/m1/s1	QOZNFPLCSPWJRX-QGZVFWFLSA-N	320069	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 236::US10202369, Example 236::US10472354, Example 236	P2X purinoceptor 2/3	Homo sapiens		 1012							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320069	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320069&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397529	384223343							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683274	Cc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1	InChI=1S/C25H28N4O3S/c1-16-5-6-20(29-28-16)14-26-24(30)18-11-19(25-27-15-23(33-25)17-3-2-4-17)13-22(12-18)32-21-7-9-31-10-8-21/h5-6,11-13,15,17,21H,2-4,7-10,14H2,1H3,(H,26,30)	KYDTWNODFNIYNY-UHFFFAOYSA-N	320070	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 237::US10202369, Example 237::US10472354, Example 237	P2X purinoceptor 2/3	Homo sapiens		 537							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320070&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397323	384223344							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683276	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(19-12-31-25(32-13-19)26(27,28)29)33-23(34)17-9-18(24-30-14-22(37-24)16-3-2-4-16)11-21(10-17)36-20-5-7-35-8-6-20/h9-16,20H,2-8H2,1H3,(H,33,34)/t15-/m1/s1	KTFAMKPHNDUKLL-OAHLLOKOSA-N	320071	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 238::US10202369, Example 238::US10472354, Example 238	P2X purinoceptor 2/3	Homo sapiens		 397							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320071	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320071&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397176	384223345							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683278	C[C@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m0/s1	JWRPHAGJMIAQMD-HOTGVXAUSA-N	320072	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 239::US10202369, Example 239::US10472354, Example 239	P2X purinoceptor 2/3	Homo sapiens		 2171							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320072	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320072&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397719	384223346							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683280	CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1	OXXUGGORGDKECE-CRAIPNDOSA-N	320073	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 240::US10202369, Example 249::US10472354, Example 240	P2X purinoceptor 2/3	Homo sapiens		 35.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320073&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397178	384223347							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683282	CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18-/m1/s1	GGGFDTSSCKHCGY-CRAIPNDOSA-N	320074	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 241::US10202369, Example 241::US10472354, Example 241	P2X purinoceptor 2/3	Homo sapiens		 533							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320074	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320074&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397675	384223348							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683284	CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17-/m1/s1	CPHCWMUXIASQAI-CXAGYDPISA-N	320075	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 242::US10202369, Example 242::US10472354, Example 242	P2X purinoceptor 2/3	Homo sapiens		 22.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320075	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320075&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397732	384223349							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683286	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20-/m1/s1	GBDWWYIZWHGLEN-OXQOHEQNSA-N	320076	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 243::US10202369, Example 243::US10472354, Example 243	P2X purinoceptor 2/3	Homo sapiens		 259							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320076	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320076&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397824	384223350							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683288	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1	FVGXVLFIHFQXPP-OXQOHEQNSA-N	320077	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 244::US10202369, Example 244::US10472354, Example 244	P2X purinoceptor 2/3	Homo sapiens		 555							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320077	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320077&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397416	384223351							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683290	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19-/m1/s1	IDGMWIXZIVCDCF-AUUYWEPGSA-N	320078	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 245::US10202369, Example 245::US10472354, Example 245	P2X purinoceptor 2/3	Homo sapiens		 142							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320078	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320078&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397471	384223352							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683292	CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19-/m1/s1	AZADLHFQZQVHQV-VQIMIIECSA-N	320079	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 246::US10202369, Example 246::US10472354, Example 246	P2X purinoceptor 2/3	Homo sapiens		 982							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320079&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397745	384223353							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683294	CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19-/m1/s1	ULUQVVVXKLITBV-VQIMIIECSA-N	320080	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 247::US10202369, Example 247::US10472354, Example 247	P2X purinoceptor 2/3	Homo sapiens		 963							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320080	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320080&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397213	384223354							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683296	CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18-/m1/s1	COCLYUAEQYUAPW-RDTXWAMCSA-N	320081	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 248::US10202369, Example 248::US10472354, Example 248	P2X purinoceptor 2/3	Homo sapiens		 273							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320081	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320081&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397577	384223355							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683298	CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1	OXXUGGORGDKECE-CRAIPNDOSA-N	320073	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 240::US10202369, Example 249::US10472354, Example 240	P2X purinoceptor 2/3	Homo sapiens		 57.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320073&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397178	384223347							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683300	CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18+/m1/s1	GGGFDTSSCKHCGY-QAPCUYQASA-N	320083	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 250::US10202369, Example 250::US10472354, Example 250	P2X purinoceptor 2/3	Homo sapiens		 299							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320083	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320083&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397653	384223357							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683302	CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17+/m1/s1	CPHCWMUXIASQAI-DYVFJYSZSA-N	320084	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 251::US10202369, Example 251::US10472354, Example 251	P2X purinoceptor 2/3	Homo sapiens		 38.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320084	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320084&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397624	384223358							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683304	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20+/m1/s1	GBDWWYIZWHGLEN-UZLBHIALSA-N	320085	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 252::US10202369, Example 252::US10472354, Example 252	P2X purinoceptor 2/3	Homo sapiens		 275							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320085	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320085&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397825	384223359							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683306	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20+/m1/s1	FVGXVLFIHFQXPP-UZLBHIALSA-N	320086	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 253::US10202369, Example 253::US10472354, Example 253	P2X purinoceptor 2/3	Homo sapiens		 598							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320086	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320086&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397513	384223360							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683308	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19+/m1/s1	IDGMWIXZIVCDCF-KUHUBIRLSA-N	320087	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 254::US10202369, Example 254::US10472354, Example 254	P2X purinoceptor 2/3	Homo sapiens		 116							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320087	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320087&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397641	384223361							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683310	CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19+/m1/s1	AZADLHFQZQVHQV-APWZRJJASA-N	320088	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 255::US10202369, Example 255::US10472354, Example 255	P2X purinoceptor 2/3	Homo sapiens		 449							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320088&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397188	384223362							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683312	CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19+/m1/s1	ULUQVVVXKLITBV-APWZRJJASA-N	320089	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 256::US10202369, Example 256::US10472354, Example 256	P2X purinoceptor 2/3	Homo sapiens		 1494							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320089	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320089&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397239	384223363							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683314	CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18+/m1/s1	COCLYUAEQYUAPW-KDOFPFPSSA-N	320090	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 257::US10202369, Example 257::US10472354, Example 257	P2X purinoceptor 2/3	Homo sapiens		 324							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320090	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320090&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397534	384223364							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683316	CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17-/m1/s1	CPQUPRVXRIYFHX-IAGOWNOFSA-N	320091	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 258::US10202369, Example 258::US10472354, Example 282	P2X purinoceptor 2/3	Homo sapiens		 38.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320091	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320091&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397177	384223365							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683318	CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17-/m1/s1	PZFOCXJBZDWRSU-IAGOWNOFSA-N	320092	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 259::US10202369, Example 259::US10472354, Example 283	P2X purinoceptor 2/3	Homo sapiens		 102							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320092	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320092&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397564	384223366							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683320	CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15-/m1/s1	VOKPPDDBRIDGES-HUUCEWRRSA-N	320093	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 260::US10202369, Example 260::US10472354, Example 260	P2X purinoceptor 2/3	Homo sapiens		 14.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320093&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397266	384223367							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683322	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18-/m1/s1	KRMAXJMLJAVOGJ-QZTJIDSGSA-N	320094	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 261::US10202369, Example 261::US10472354, Example 261	P2X purinoceptor 2/3	Homo sapiens		 317							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320094&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397842	384223368							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683324	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18-/m1/s1	ZBRXLMDGZXDHGV-QZTJIDSGSA-N	320095	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 262::US10202369, Example 262::US10472354, Example 262	P2X purinoceptor 2/3	Homo sapiens		 383							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320095&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397383	384223369							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683326	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m1/s1	JWRPHAGJMIAQMD-HZPDHXFCSA-N	320096	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 263::US10202369, Example 263::US10472354, Example 263	P2X purinoceptor 2/3	Homo sapiens		 170							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320096&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397122	384223370							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683328	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18-/m1/s1	HVLSFPXITWENER-QZTJIDSGSA-N	320097	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 264::US10202369, Example 264::US10472354, Example 264	P2X purinoceptor 2/3	Homo sapiens		 530							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320097	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320097&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397620	384223371							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683330	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18-/m1/s1	MWBSFWZECXCRJX-QZTJIDSGSA-N	320098	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 265::US10202369, Example 265::US10472354, Example 265	P2X purinoceptor 2/3	Homo sapiens		 696							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320098	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320098&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397233	384223372							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683332	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16-/m1/s1	JZRSBKDBMGCFDH-HZPDHXFCSA-N	320099	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 266::US10202369, Example 266::US10472354, Example 266	P2X purinoceptor 2/3	Homo sapiens		 367							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320099&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397337	384223373							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683334	CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19-/m1/s1	CEYURJDFNAEZIM-VQIMIIECSA-N	320100	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 267::US10202369, Example 276	P2X purinoceptor 2/3	Homo sapiens		 173							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320100	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320100&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397219	384223374							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683336	CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19-/m1/s1	AKBLPSFNNBDTQK-VQIMIIECSA-N	320101	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 268::US10202369, Example 277	P2X purinoceptor 2/3	Homo sapiens		 392							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320101	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320101&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397780	384223375							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683338	CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18-/m1/s1	IDFXYIYQWCENGA-RDTXWAMCSA-N	320102	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 269::US10202369, Example 278	P2X purinoceptor 2/3	Homo sapiens		 35.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320102	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320102&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397217	384223376							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683340	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21-/m1/s1	NLLVDMMXBRFWGS-DYESRHJHSA-N	320103	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 270::US10202369, Example 270	P2X purinoceptor 2/3	Homo sapiens		 100.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320103	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320103&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397499	384223377							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683342	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21-/m1/s1	BHRXSWOPMLFOCG-DYESRHJHSA-N	320104	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 271::US10202369, Example 271	P2X purinoceptor 2/3	Homo sapiens		 230							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320104	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320104&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397691	384223378							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683344	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20-/m1/s1	ZERBIURYMMOJBU-FOIQADDNSA-N	320105	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 272::US10202369, Example 272	P2X purinoceptor 2/3	Homo sapiens		 128							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320105	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320105&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397162	384223379							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683346	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20-/m1/s1	UAMKMSQRQBQFJK-YLJYHZDGSA-N	320106	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 273::US10202369, Example 279	P2X purinoceptor 2/3	Homo sapiens		 254							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320106	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320106&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397845	384223380							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683348	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20-/m1/s1	CNKRLRNKYMMPAE-YLJYHZDGSA-N	320107	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 274::US10202369, Example 280	P2X purinoceptor 2/3	Homo sapiens		 873							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320107&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397759	384223381							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683350	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19-/m1/s1	KTCCKJLURHRITN-DNVCBOLYSA-N	320108	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 275::US10202369, Example 281	P2X purinoceptor 2/3	Homo sapiens		 191							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320108&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397795	384223382							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683352	CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19-/m1/s1	CEYURJDFNAEZIM-VQIMIIECSA-N	320100	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 267::US10202369, Example 276	P2X purinoceptor 2/3	Homo sapiens		 76.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320100	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320100&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397219	384223374							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683354	CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19-/m1/s1	AKBLPSFNNBDTQK-VQIMIIECSA-N	320101	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 268::US10202369, Example 277	P2X purinoceptor 2/3	Homo sapiens		 96.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320101	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320101&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397780	384223375							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683356	CCc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18-/m1/s1	IDFXYIYQWCENGA-RDTXWAMCSA-N	320102	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 269::US10202369, Example 278	P2X purinoceptor 2/3	Homo sapiens		 23.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320102	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320102&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397217	384223376							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683358	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20-/m1/s1	UAMKMSQRQBQFJK-YLJYHZDGSA-N	320106	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 273::US10202369, Example 279	P2X purinoceptor 2/3	Homo sapiens		 956							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320106	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320106&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397845	384223380							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683360	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20-/m1/s1	CNKRLRNKYMMPAE-YLJYHZDGSA-N	320107	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 274::US10202369, Example 280	P2X purinoceptor 2/3	Homo sapiens		 682							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320107	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320107&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397759	384223381							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683362	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19-/m1/s1	KTCCKJLURHRITN-DNVCBOLYSA-N	320108	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 275::US10202369, Example 281	P2X purinoceptor 2/3	Homo sapiens		 198							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320108	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320108&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397795	384223382							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683364	CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-13-25-24(32-21)18-10-17(11-20(12-18)31-14-19-6-5-9-30-19)23(29)26-16(3)22-8-7-15(2)27-28-22/h7-8,10-13,16,19H,4-6,9,14H2,1-3H3,(H,26,29)/t16-,19+/m1/s1	CEYURJDFNAEZIM-APWZRJJASA-N	320115	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 282::US10202369, Example 282	P2X purinoceptor 2/3	Homo sapiens		 209							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320115	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320115&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397632	384223389							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683366	CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-12-27-24(32-21)18-8-17(9-20(10-18)31-14-19-6-5-7-30-19)23(29)28-16(3)22-13-25-15(2)11-26-22/h8-13,16,19H,4-7,14H2,1-3H3,(H,28,29)/t16-,19+/m1/s1	AKBLPSFNNBDTQK-APWZRJJASA-N	320116	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 283::US10202369, Example 283	P2X purinoceptor 2/3	Homo sapiens		 379							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320116	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320116&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397578	384223390							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683368	CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18+/m1/s1	IDFXYIYQWCENGA-KDOFPFPSSA-N	320117	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 284::US10202369, Example 284::US10472354, Example 284	P2X purinoceptor 2/3	Homo sapiens		 57.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320117&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397623	384223391							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683370	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21+/m1/s1	NLLVDMMXBRFWGS-UTKZUKDTSA-N	320118	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 285::US10202369, Example 285::US10472354, Example 285	P2X purinoceptor 2/3	Homo sapiens		 760							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320118&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397163	384223392							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683372	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21+/m1/s1	BHRXSWOPMLFOCG-UTKZUKDTSA-N	320119	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 286::US10202369, Example 286::US10472354, Example 286	P2X purinoceptor 2/3	Homo sapiens		 1234							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320119&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397754	384223393							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683374	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20+/m1/s1	ZERBIURYMMOJBU-QRWLVFNGSA-N	320120	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 287::US10202369, Example 287::US10472354, Example 287	P2X purinoceptor 2/3	Homo sapiens		 275							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320120&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397159	384223394							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683376	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20+/m1/s1	UAMKMSQRQBQFJK-XLIONFOSSA-N	320121	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 288::US10202369, Example 288::US10472354, Example 288	P2X purinoceptor 2/3	Homo sapiens		 1314							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320121&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397738	384223395							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683378	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20+/m1/s1	CNKRLRNKYMMPAE-XLIONFOSSA-N	320122	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 289::US10202369, Example 289::US10472354, Example 289	P2X purinoceptor 2/3	Homo sapiens		 1768							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320122	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320122&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397419	384223396							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683380	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F	InChI=1S/C26H28F3N3O3S/c1-15(2)22-13-31-25(36-22)19-9-18(10-21(11-19)35-14-20-5-4-8-34-20)24(33)32-16(3)17-6-7-23(30-12-17)26(27,28)29/h6-7,9-13,15-16,20H,4-5,8,14H2,1-3H3,(H,32,33)/t16-,20+/m1/s1	USOMQOKPGJTCRC-UZLBHIALSA-N	346303	3-[5-(propan- 2-yl)- 1,3-thiazol-2-yl]- 5-[(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}::US10202369, Example 290	P2X purinoceptor 2/3	Homo sapiens		 368							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346303	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346303&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134391358	385452349							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683382	C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m0/s1	GTQPEQGDLVSFJO-SUMWQHHRSA-N	320124	3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1S)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 291::US10202369, Example 291	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320124	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320124&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397365	384223398							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683384	CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15-/m1/s1	PGRAVNCJCWWOPT-HUUCEWRRSA-N	320125	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 292::US10202369, Example 292	P2X purinoceptor 2/3	Homo sapiens		 52.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320125	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320125&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397547	384223399							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683386	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16-/m1/s1	ZWFOSAQPAKMJAC-HZPDHXFCSA-N	320126	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 293::US10202369, Example 301	P2X purinoceptor 2/3	Homo sapiens		 1155							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320126&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397373	384223400							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683388	CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-23(35-20)16-8-15(9-18(10-16)34-17-6-7-33-12-17)22(32)29-14(3)19-4-5-21(31-30-19)24(25,26)27/h4-5,8-11,13-14,17H,6-7,12H2,1-3H3,(H,29,32)/t14-,17-/m1/s1	ALCUBFBGIYQDIY-RHSMWYFYSA-N	320127	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 294::US10202369, Example 294::US10472354, Example 294	P2X purinoceptor 2/3	Homo sapiens		 1060							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320127&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397844	384223401							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682802	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O2S/c1-12-8-26-20(32-12)16-5-15(6-18(7-16)31-11-14-3-4-14)19(30)29-13(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,29,30)/t13-/m1/s1	KPIHUQDIFGXEHA-CYBMUJFWSA-N	319834	3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 1::US10202369, Example 1::US10472354, Example 1	P2X purinoceptor 2/3	Homo sapiens		 76.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319834	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319834&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397250	384223114							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682804	Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C21H22N4O2S/c1-13-3-6-18(25-24-13)11-22-20(26)16-7-17(21-23-10-14(2)28-21)9-19(8-16)27-12-15-4-5-15/h3,6-10,15H,4-5,11-12H2,1-2H3,(H,22,26)	LHMIEJIRNSAGER-UHFFFAOYSA-N	319835	3-(Cyclopropylmethoxy)-N-[(6-methylpyridazin-3-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 2::US10202369, Example 2::US10472354, Example 2	P2X purinoceptor 2/3	Homo sapiens		 251							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319835	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319835&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397260	384223115							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682806	Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C21H22N4O2S/c1-13-8-23-18(10-22-13)11-24-20(26)16-5-17(21-25-9-14(2)28-21)7-19(6-16)27-12-15-3-4-15/h5-10,15H,3-4,11-12H2,1-2H3,(H,24,26)	SHCAJJQUYCQWRM-UHFFFAOYSA-N	319836	3-(Cyclopropylmethoxy)-N-[(5-methylpyrazin-2-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 3::US10202369, Example 3::US10472354, Example 3	P2X purinoceptor 2/3	Homo sapiens		 1106							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319836	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319836&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397194	384223116							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682808	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C22H24N4O2S/c1-13-9-24-20(11-23-13)15(3)26-21(27)17-6-18(22-25-10-14(2)29-22)8-19(7-17)28-12-16-4-5-16/h6-11,15-16H,4-5,12H2,1-3H3,(H,26,27)/t15-/m1/s1	DYWYLXQLERQEEM-OAHLLOKOSA-N	319837	3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 4::US10202369, Example 4::US10472354, Example 4	P2X purinoceptor 2/3	Homo sapiens		 98.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319837&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397428	384223117							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682810	CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(23)8-17(24)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28)	CGCJNRQFWMKWFU-UHFFFAOYSA-N	319838	N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 5::US10202369, Example 5::US10472354, Example 5	P2X purinoceptor 2/3	Homo sapiens		 346							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319838	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319838&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397491	384223118							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682812	CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(24)8-17(23)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28)	YIPUFXDTAKNGSX-UHFFFAOYSA-N	319839	N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 6::US10202369, Example 6::US10472354, Example 6	P2X purinoceptor 2/3	Homo sapiens		 38.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319839	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319839&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397488	384223119							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682814	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1	InChI=1S/C20H22N4O2S2/c1-11-9-21-20(27-11)16-6-15(7-17(8-16)26-10-14-4-5-14)18(25)22-12(2)19-24-23-13(3)28-19/h6-9,12,14H,4-5,10H2,1-3H3,(H,22,25)/t12-/m1/s1	QOCVVHCSVZQPAR-GFCCVEGCSA-N	319840	3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 7::US10202369, Example 7::US10472354, Example 7	P2X purinoceptor 2/3	Homo sapiens		 106							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319840	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319840&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397154	384223120							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682816	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C22H24N4O2S/c1-13-4-7-20(26-25-13)15(3)24-21(27)17-8-18(22-23-11-14(2)29-22)10-19(9-17)28-12-16-5-6-16/h4,7-11,15-16H,5-6,12H2,1-3H3,(H,24,27)/t15-/m1/s1	ZZPHBEIBURIANJ-OAHLLOKOSA-N	319841	3-(Cyclopropylmethoxy)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 8::US10202369, Example 8::US10472354, Example 8	P2X purinoceptor 2/3	Homo sapiens		 90.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319841	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319841&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397204	384223121							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682818	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H21F3N4O2S/c1-12-10-26-21(32-12)16-7-15(8-17(9-16)31-11-14-3-4-14)20(30)27-13(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,30)/t13-/m1/s1	FDEHTNMFMQMRCT-CYBMUJFWSA-N	319842	3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 9::US10202369, Example 9::US10472354, Example 9	P2X purinoceptor 2/3	Homo sapiens		 145							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319842	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319842&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397573	384223122							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682820	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C22H24N4O2S/c1-13-9-25-22(29-13)18-6-17(7-20(8-18)28-12-16-4-5-16)21(27)26-14(2)19-10-23-15(3)24-11-19/h6-11,14,16H,4-5,12H2,1-3H3,(H,26,27)/t14-/m1/s1	HEHYSAYIHLPEGC-CQSZACIVSA-N	319843	3-(Cyclopropylmethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 10::US10202369, Example 10::US10472354, Example 10	P2X purinoceptor 2/3	Homo sapiens		 185							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319843	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319843&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397702	384223123							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682822	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1	GTQPEQGDLVSFJO-CXAGYDPISA-N	319844	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 11::US10202369, Example 11::US10472354, Example 291	P2X purinoceptor 2/3	Homo sapiens		 163							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319844	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319844&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397587	384223124							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682824	Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C21H22N4O3S/c1-13-8-23-17(10-22-13)11-24-20(26)15-5-16(21-25-9-14(2)29-21)7-19(6-15)28-18-3-4-27-12-18/h5-10,18H,3-4,11-12H2,1-2H3,(H,24,26)/t18-/m1/s1	SKCSTCBULJTUPE-GOSISDBHSA-N	319845	N-[(5-methylpyrazin-2-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 12::US10202369, Example 12	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319845	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319845&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397167	384223125							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682826	CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1	YETTUNLUNMEXML-LRHAYUFXSA-N	319846	N-[1-(3-chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 13::US10202369, Example 13::US10472354, Example 13	P2X purinoceptor 2/3	Homo sapiens		 1102							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319846	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319846&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397669	384223126							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682828	CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1	DLODQDUFIVUCLQ-LRHAYUFXSA-N	319847	N-[1-(5-chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 14::US10202369, Example 14::US10472354, Example 14	P2X purinoceptor 2/3	Homo sapiens		 88.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319847	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319847&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397583	384223127							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682830	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1	InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18-/m1/s1	DURBVTDNVKUTOV-RDTXWAMCSA-N	319848	N-[(1R)-1-(5-chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 15::US10202369, Example 15::US10472354, Example 15	P2X purinoceptor 2/3	Homo sapiens		 147							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319848	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319848&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397630	384223128							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682832	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18-/m1/s1	GGLGXVJJVCGSBA-CRAIPNDOSA-N	319849	N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 16::US10202369, Example 16::US10472354, Example 16	P2X purinoceptor 2/3	Homo sapiens		 1707							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319849	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319849&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397267	384223129							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682834	Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m1/s1	VKRRMZCTKMLCQJ-GOSISDBHSA-N	319850	N-[(6-methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 17::US10202369, Example 17::US10472354, Example 17	P2X purinoceptor 2/3	Homo sapiens		 1005							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319850	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319850&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397146	384223130							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682836	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18-/m1/s1	JJXMVDHMQZPOJY-CRAIPNDOSA-N	319851	N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 18::US10202369, Example 18::US10472354, Example 18	P2X purinoceptor 2/3	Homo sapiens		 427							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319851	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319851&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397758	384223131							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682838	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-10-26-21(33-12)15-7-14(8-17(9-15)32-16-5-6-31-11-16)20(30)27-13(2)18-3-4-19(29-28-18)22(23,24)25/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,27,30)/t13-,16-/m1/s1	DNHMMXLROIMBSA-CZUORRHYSA-N	319852	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 19::US10202369, Example 19::US10472354, Example 19	P2X purinoceptor 2/3	Homo sapiens		 749							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319852	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319852&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397747	384223132							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682840	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1	InChI=1S/C20H22N4O3S2/c1-11-9-21-20(28-11)15-6-14(7-17(8-15)27-16-4-5-26-10-16)18(25)22-12(2)19-24-23-13(3)29-19/h6-9,12,16H,4-5,10H2,1-3H3,(H,22,25)/t12-,16-/m1/s1	WVNVOAPVSAUSTP-MLGOLLRUSA-N	319853	N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 20::US10202369, Example 20::US10472354, Example 20	P2X purinoceptor 2/3	Homo sapiens		 486							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319853	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319853&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397835	384223133							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682842	Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F	InChI=1S/C21H19F3N4O3S/c1-12-9-26-20(32-12)14-6-13(7-17(8-14)31-16-4-5-30-11-16)19(29)25-10-15-2-3-18(28-27-15)21(22,23)24/h2-3,6-9,16H,4-5,10-11H2,1H3,(H,25,29)/t16-/m1/s1	YZCYRJHHBOIVER-MRXNPFEDSA-N	319854	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{[6-(trifluoromethyl)pyridazin-3-yl]methyl}benzamide::US10174016, Example 21::US10202369, Example 21::US10472354, Example 21	P2X purinoceptor 2/3	Homo sapiens		 445							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319854	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319854&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397575	384223134							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682844	CC[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-3-19(16-10-28-22(29-11-16)23(24,25)26)30-20(31)14-6-15(21-27-9-13(2)34-21)8-18(7-14)33-17-4-5-32-12-17/h6-11,17,19H,3-5,12H2,1-2H3,(H,30,31)/t17-,19-/m1/s1	VUXDKUAYZMWTBM-IEBWSBKVSA-N	319855	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]propyl}benzamide::US10174016, Example 22::US10202369, Example 22::US10472354, Example 22	P2X purinoceptor 2/3	Homo sapiens		 987							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319855	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319855&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397246	384223135							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682846	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19-/m1/s1	RHVHBKMOULQMJQ-AUUYWEPGSA-N	319856	N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 23::US10202369, Example 23	P2X purinoceptor 2/3	Homo sapiens		 1106							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319856	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319856&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397288	384223136							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682848	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20-/m1/s1	KGDPEGCMVCXNPY-OXQOHEQNSA-N	319857	N-[(1R)-1-(6-Methylpyridin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 24::US10202369, Example 24	P2X purinoceptor 2/3	Homo sapiens		 332							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319857	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319857&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397467	384223137							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682850	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18+/m1/s1	JJXMVDHMQZPOJY-QAPCUYQASA-N	319858	N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 25::US10202369, Example 25::US10472354, Example 25	P2X purinoceptor 2/3	Homo sapiens		 975							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319858	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319858&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397569	384223138							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682852	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m1/s1	GTQPEQGDLVSFJO-DYVFJYSZSA-N	319859	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 26::US10202369, Example 26::US10472354, Example 26	P2X purinoceptor 2/3	Homo sapiens		 297							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319859&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397418	384223139							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682854	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1	InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18+/m1/s1	DURBVTDNVKUTOV-KDOFPFPSSA-N	319860	N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 27::US10202369, Example 27::US10472354, Example 27	P2X purinoceptor 2/3	Homo sapiens		 280							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319860	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319860&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397158	384223140							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682856	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)cn1	InChI=1S/C23H25N3O3S/c1-14-4-5-21(24-11-14)16(3)26-22(27)17-8-18(23-25-12-15(2)30-23)10-20(9-17)29-19-6-7-28-13-19/h4-5,8-12,16,19H,6-7,13H2,1-3H3,(H,26,27)/t16-,19+/m1/s1	CFTQNAYGOFQJGD-APWZRJJASA-N	319861	N-[(1R)-1-(5-Methylpyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 28::US10202369, Example 28::US10472354, Example 28	P2X purinoceptor 2/3	Homo sapiens		 121							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319861	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319861&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397224	384223141							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682858	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(Cl)cn1	InChI=1S/C21H21ClN4O3S/c1-12-8-25-21(30-12)15-5-14(6-17(7-15)29-16-3-4-28-11-16)20(27)26-13(2)18-9-24-19(22)10-23-18/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16+/m1/s1	WDGLIKLPMFVJPN-CJNGLKHVSA-N	346042	N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10202369, Example 29	P2X purinoceptor 2/3	Homo sapiens		 580							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346042&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134391353	385452094							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682860	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20+/m1/s1	KGDPEGCMVCXNPY-UZLBHIALSA-N	319863	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran- 3-yloxy] benzamide::US10174016, Example 30::US10202369, Example 30::US10472354, Example 30	P2X purinoceptor 2/3	Homo sapiens		 485							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319863&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397828	384223143							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683390	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H25F3N4O3S/c1-14(20-5-6-22(32-31-20)25(26,27)28)30-23(33)16-9-17(11-19(10-16)35-18-7-8-34-13-18)24-29-12-21(36-24)15-3-2-4-15/h5-6,9-12,14-15,18H,2-4,7-8,13H2,1H3,(H,30,33)/t14-,18+/m1/s1	LCHSLMNVJPMESH-KDOFPFPSSA-N	320128	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 295::US10202369, Example 295::US10472354, Example 295	P2X purinoceptor 2/3	Homo sapiens		 557							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320128	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320128&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397441	384223402							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683392	CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15+/m1/s1	PGRAVNCJCWWOPT-CABCVRRESA-N	320129	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 296::US10202369, Example 296::US10472354, Example 296	P2X purinoceptor 2/3	Homo sapiens		 133							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320129	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320129&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397487	384223403							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683394	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(21-5-6-23(33-32-21)26(27,28)29)31-24(34)18-9-19(25-30-12-22(37-25)17-3-2-4-17)11-20(10-18)36-14-16-7-8-35-13-16/h5-6,9-12,15-17H,2-4,7-8,13-14H2,1H3,(H,31,34)/t15-,16-/m1/s1	BURFLVDKSSJHQL-HZPDHXFCSA-N	320130	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 297::US10202369, Example 300::US10472354, Example 297	P2X purinoceptor 2/3	Homo sapiens		 933							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320130&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397174	384223404							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683396	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16+/m1/s1	ZWFOSAQPAKMJAC-CVEARBPZSA-N	320131	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 298::US10202369, Example 299::US10472354, Example 298	P2X purinoceptor 2/3	Homo sapiens		 781							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320131	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320131&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397407	384223405							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683398	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16+/m1/s1	ZWFOSAQPAKMJAC-CVEARBPZSA-N	320131	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 298::US10202369, Example 299::US10472354, Example 298	P2X purinoceptor 2/3	Homo sapiens		 575							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320131	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320131&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397407	384223405							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683400	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(21-5-6-23(33-32-21)26(27,28)29)31-24(34)18-9-19(25-30-12-22(37-25)17-3-2-4-17)11-20(10-18)36-14-16-7-8-35-13-16/h5-6,9-12,15-17H,2-4,7-8,13-14H2,1H3,(H,31,34)/t15-,16-/m1/s1	BURFLVDKSSJHQL-HZPDHXFCSA-N	320130	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 297::US10202369, Example 300::US10472354, Example 297	P2X purinoceptor 2/3	Homo sapiens		 820							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320130&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397174	384223404							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683402	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16-/m1/s1	ZWFOSAQPAKMJAC-HZPDHXFCSA-N	320126	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 293::US10202369, Example 301	P2X purinoceptor 2/3	Homo sapiens		 1714							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320126	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320126&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397373	384223400							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683404	CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-19-12-28-23(35-19)16-9-15(10-18(11-16)34-13-17-5-4-8-33-17)22(32)29-14(2)20-6-7-21(31-30-20)24(25,26)27/h6-7,9-12,14,17H,3-5,8,13H2,1-2H3,(H,29,32)/t14-,17+/m1/s1	JBKILHBMFZDIIA-PBHICJAKSA-N	320135	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 302::US10202369, Example 302::US10472354, Example 302	P2X purinoceptor 2/3	Homo sapiens		 145							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320135&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397753	384223409							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683406	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m1/s1	HEBACSHOFHMYBR-OAHLLOKOSA-N	320136	3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 303::US10202369, Example 310::US10472354, Example 303	P2X purinoceptor 2/3	Homo sapiens		 38.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320136&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397490	384223410							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683408	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m1/s1	LOLIYPRJHUXCPO-OAHLLOKOSA-N	320137	3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoroethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 304::US10202369, Example 308::US10472354, Example 304	P2X purinoceptor 2/3	Homo sapiens		 27.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320137&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397386	384223411							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683410	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C25H29F2N5O2S/c1-15-4-5-22(31-30-15)17(3)29-24(33)18-10-19(25-28-13-16(2)35-25)12-21(11-18)34-20-6-8-32(9-7-20)14-23(26)27/h4-5,10-13,17,20,23H,6-9,14H2,1-3H3,(H,29,33)/t17-/m1/s1	BZVNHOBJGKGQCM-QGZVFWFLSA-N	320138	3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 305::US10202369, Example 305::US10472354, Example 305	P2X purinoceptor 2/3	Homo sapiens		 44.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320138&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397226	384223412							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683412	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C25H29F2N5O2S/c1-15-11-29-22(13-28-15)17(3)31-24(33)18-8-19(25-30-12-16(2)35-25)10-21(9-18)34-20-4-6-32(7-5-20)14-23(26)27/h8-13,17,20,23H,4-7,14H2,1-3H3,(H,31,33)/t17-/m1/s1	OVUBAZICSOPILB-QGZVFWFLSA-N	320139	3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 306::US10202369, Example 306::US10472354, Example 306	P2X purinoceptor 2/3	Homo sapiens		 464							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320139&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397132	384223413							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683414	Cc1cnc(s1)-c1cc(OC2CCN(CC(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C24H27F2N5O2S/c1-15-3-4-19(30-29-15)13-27-23(32)17-9-18(24-28-12-16(2)34-24)11-21(10-17)33-20-5-7-31(8-6-20)14-22(25)26/h3-4,9-12,20,22H,5-8,13-14H2,1-2H3,(H,27,32)	AGOFJROZQVOSRF-UHFFFAOYSA-N	320140	3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(6-methylpyridazin- 3-yl)methyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 307::US10202369, Example 307::US10472354, Example 307	P2X purinoceptor 2/3	Homo sapiens		 103							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320140&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397369	384223414							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683416	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m1/s1	LOLIYPRJHUXCPO-OAHLLOKOSA-N	320137	3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoroethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 304::US10202369, Example 308::US10472354, Example 304	P2X purinoceptor 2/3	Homo sapiens		 2586							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320137&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397386	384223411							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683418	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C25H29F2N5O2S/c1-15-11-30-25(35-15)19-8-18(24(33)31-16(2)20-12-28-17(3)29-13-20)9-22(10-19)34-21-4-6-32(7-5-21)14-23(26)27/h8-13,16,21,23H,4-7,14H2,1-3H3,(H,31,33)/t16-/m1/s1	XIVLMPYTLPVWPV-MRXNPFEDSA-N	320142	3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 309::US10202369, Example 309::US10472354, Example 309	P2X purinoceptor 2/3	Homo sapiens		 70.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320142&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397638	384223416							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683420	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m1/s1	HEBACSHOFHMYBR-OAHLLOKOSA-N	320136	3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 303::US10202369, Example 310::US10472354, Example 303	P2X purinoceptor 2/3	Homo sapiens		 1678							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320136&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397490	384223410							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683422	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C25H28F3N5O2S/c1-15-4-5-22(32-31-15)17(3)30-23(34)18-10-19(24-29-13-16(2)36-24)12-21(11-18)35-20-6-8-33(9-7-20)14-25(26,27)28/h4-5,10-13,17,20H,6-9,14H2,1-3H3,(H,30,34)/t17-/m1/s1	PEAPNGOBIXQGEJ-QGZVFWFLSA-N	320144	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 311::US10202369, Example 311::US10472354, Example 314	P2X purinoceptor 2/3	Homo sapiens		 35.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320144&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397300	384223418							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683424	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-14-12-32-23(39-14)17-9-16(22(37)33-15(2)20-3-4-21(35-34-20)25(29,30)31)10-19(11-17)38-18-5-7-36(8-6-18)13-24(26,27)28/h3-4,9-12,15,18H,5-8,13H2,1-2H3,(H,33,37)/t15-/m1/s1	AZRJUXHXOIFVSM-OAHLLOKOSA-N	320145	3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 312::US10202369, Example 312::US10472354, Example 312	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320145&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397364	384223419							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683426	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C25H28F3N5O2S/c1-15-11-30-22(13-29-15)17(3)32-23(34)18-8-19(24-31-12-16(2)36-24)10-21(9-18)35-20-4-6-33(7-5-20)14-25(26,27)28/h8-13,17,20H,4-7,14H2,1-3H3,(H,32,34)/t17-/m1/s1	VOYLEHBGAUIAGN-QGZVFWFLSA-N	320146	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4- yl]oxy}benzamide::US10174016, Example 313::US10202369, Example 313::US10472354, Example 313	P2X purinoceptor 2/3	Homo sapiens		 200							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320146&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397805	384223420							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683428	Cc1cnc(s1)-c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C24H26F3N5O2S/c1-15-3-4-19(31-30-15)13-28-22(33)17-9-18(23-29-12-16(2)35-23)11-21(10-17)34-20-5-7-32(8-6-20)14-24(25,26)27/h3-4,9-12,20H,5-8,13-14H2,1-2H3,(H,28,33)	OUYWWDOEFAUISF-UHFFFAOYSA-N	320147	N-[(6- methylpyridazin-3- yl)methyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 314::US10202369, Example 314	P2X purinoceptor 2/3	Homo sapiens		 192							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320147	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320147&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397402	384223421							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683430	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C25H28F3N5O2S/c1-15-11-31-24(36-15)19-8-18(23(34)32-16(2)20-12-29-17(3)30-13-20)9-22(10-19)35-21-4-6-33(7-5-21)14-25(26,27)28/h8-13,16,21H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1	CJWKMIQNKLHRQL-MRXNPFEDSA-N	320148	N-[(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 315::US10202369, Example 315::US10472354, Example 315	P2X purinoceptor 2/3	Homo sapiens		 160							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320148&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397608	384223422							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683432	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)C1NC=C(Cl)S1)c1ccc(C)nn1	InChI=1S/C22H25ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)16-7-17(22-24-10-20(23)31-22)9-18(8-16)30-12-15-5-6-29-11-15/h3-4,7-10,14-15,22,24H,5-6,11-12H2,1-2H3,(H,25,28)/t14-,15+,22?/m1/s1	QWUQFFBGJOHYNC-VBIGTEDFSA-N	346329	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methyl- pyridazin-3- yl)ethyl]- 5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10202369, Example 316	P2X purinoceptor 2/3	Homo sapiens		 250							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=346329	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=346329&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134391359	385452375							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683434	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1	InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16-/m1/s1	GKNCXHRLEQHNKW-CZUORRHYSA-N	320150	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 317::US10202369, Example 317::US10472354, Example 317	P2X purinoceptor 2/3	Homo sapiens		 952							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320150&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397433	384223424							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683436	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14-/m1/s1	WZQSUVWYIQCPQJ-BXUZGUMPSA-N	320151	3-(5-chloro-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 318::US10202369, Example 318::US10472354, Example 318	P2X purinoceptor 2/3	Homo sapiens		 476							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320151&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397509	384223425							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683438	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1	InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16-/m1/s1	NPEHDEPJRQIOFY-CZUORRHYSA-N	320152	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 319::US10202369, Example 319::US10472354, Example 319	P2X purinoceptor 2/3	Homo sapiens		 1324							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320152&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397412	384223426							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683440	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14+/m1/s1	WZQSUVWYIQCPQJ-RISCZKNCSA-N	320153	3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 320::US10202369, Example 320::US10472354, Example 320	P2X purinoceptor 2/3	Homo sapiens		 627							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320153&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397157	384223427							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683442	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1	InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16+/m1/s1	NPEHDEPJRQIOFY-CJNGLKHVSA-N	320154	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 321::US10202369, Example 321::US10472354, Example 321	P2X purinoceptor 2/3	Homo sapiens		 1447							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320154&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397403	384223428							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683444	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1	InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16+/m1/s1	GKNCXHRLEQHNKW-CJNGLKHVSA-N	320155	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 322::US10202369, Example 322::US10472354, Example 322	P2X purinoceptor 2/3	Homo sapiens		 498							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320155&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397765	384223429							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683446	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H20ClF3N4O3S/c1-12(16-7-28-21(29-8-16)22(24,25)26)30-19(31)14-4-15(20-27-9-18(23)34-20)6-17(5-14)33-11-13-2-3-32-10-13/h4-9,12-13H,2-3,10-11H2,1H3,(H,30,31)/t12-,13+/m1/s1	SQNSHDCXZQFUAQ-OLZOCXBDSA-N	320156	3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 323::US10202369, Example 323::US10472354, Example 323	P2X purinoceptor 2/3	Homo sapiens		 411							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320156&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397761	384223430							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683448	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1	InChI=1S/C22H23ClN4O3S/c1-13-10-25-19(11-24-13)14(2)27-21(28)15-7-16(22-26-12-20(23)31-22)9-18(8-15)30-17-3-5-29-6-4-17/h7-12,14,17H,3-6H2,1-2H3,(H,27,28)/t14-/m1/s1	LHUVAVZJRUVQTK-CQSZACIVSA-N	320157	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 324::US10202369, Example 324::US10472354, Example 324	P2X purinoceptor 2/3	Homo sapiens		 552							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320157&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397374	384223431							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683450	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1	InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)15-9-16(22-24-12-20(23)31-22)11-18(10-15)30-17-5-7-29-8-6-17/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,25,28)/t14-/m1/s1	WDEIMZWFSWTCLU-CQSZACIVSA-N	320158	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 325::US10202369, Example 325::US10472354, Example 325	P2X purinoceptor 2/3	Homo sapiens		 235							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320158&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397325	384223432							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683452	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H20ClF3N4O3S/c1-12(17-2-3-18(30-29-17)22(24,25)26)28-20(31)13-8-14(21-27-11-19(23)34-21)10-16(9-13)33-15-4-6-32-7-5-15/h2-3,8-12,15H,4-7H2,1H3,(H,28,31)/t12-/m1/s1	LBZPSHGDCXIMLR-GFCCVEGCSA-N	320159	3-(5-chloro-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 326::US10202369, Example 326::US10472354, Example 326	P2X purinoceptor 2/3	Homo sapiens		 378							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320159&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397539	384223433							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683454	C[C@@H](NC(=O)c1cc(OCC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-7-27-20(34-13)16-4-15(5-18(6-16)33-12-22(3)10-32-11-22)19(31)30-14(2)17-8-28-21(29-9-17)23(24,25)26/h4-9,14H,10-12H2,1-3H3,(H,30,31)/t14-/m1/s1	JVDZTZBJXQINIP-CQSZACIVSA-N	320160	3-[(3- methyloxetan-3- yl)methoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 327::US10202369, Example 327::US10472354, Example 327	P2X purinoceptor 2/3	Homo sapiens		 239							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320160&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397492	384223434							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682862	Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C20H18N4O2S/c1-4-7-26-18-9-15(8-16(10-18)20-22-11-14(3)27-20)19(25)21-12-17-6-5-13(2)23-24-17/h1,5-6,8-11H,7,12H2,2-3H3,(H,21,25)	JDOBHPRLWOBCFP-UHFFFAOYSA-N	319864	N-[(6- Methylpyridazin-  3-yl)methyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 31::US10202369, Example 31::US10472354, Example 31	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319864&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397457	384223144							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682864	Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ncc(Cl)cc1F	InChI=1S/C20H15ClFN3O2S/c1-3-4-27-16-6-13(5-14(7-16)20-25-9-12(2)28-20)19(26)24-11-18-17(22)8-15(21)10-23-18/h1,5-10H,4,11H2,2H3,(H,24,26)	VKJAMZXKIQCHSG-UHFFFAOYSA-N	322220	N-[(5-Chloro-3- fluoropyridin-2- yl)methyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10183937, Example 32::US10202369, Example 32::US10472354, Example 32	P2X purinoceptor 2/3	Homo sapiens		 1781							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322220&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397185	384225297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682866	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C22H21N3O2S/c1-5-8-27-20-10-18(9-19(11-20)22-24-12-15(3)28-22)21(26)25-16(4)17-7-6-14(2)23-13-17/h1,6-7,9-13,16H,8H2,2-4H3,(H,25,26)/t16-/m1/s1	ZCHZUISZWKOUTB-MRXNPFEDSA-N	319866	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 33::US10202369, Example 33::US10472354, Example 33	P2X purinoceptor 2/3	Homo sapiens		 912							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319866&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397790	384223146							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682868	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C21H20N4O2S/c1-5-6-27-18-8-16(7-17(9-18)21-24-11-14(3)28-21)20(26)25-15(4)19-12-22-13(2)10-23-19/h1,7-12,15H,6H2,2-4H3,(H,25,26)/t15-/m1/s1	UJLVWKMINNYJSM-OAHLLOKOSA-N	319867	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 34::US10202369, Example 34::US10472354, Example 34	P2X purinoceptor 2/3	Homo sapiens		 2124							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319867&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397514	384223147							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682870	Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C20H18N4O2S/c1-4-5-26-18-7-15(6-16(8-18)20-24-10-14(3)27-20)19(25)23-12-17-11-21-13(2)9-22-17/h1,6-11H,5,12H2,2-3H3,(H,23,25)	HKQDCIZFKBUDQD-UHFFFAOYSA-N	319868	N-[(5- Methylpyrazin- 2-yl)methyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy)benzamide::US10174016, Example 35::US10202369, Example 35::US10472354, Example 35	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319868&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397704	384223148							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682872	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m1/s1	BTRSFHCVZJPJKT-CYBMUJFWSA-N	319869	3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 36::US10202369, Example 36::US10472354, Example 36	P2X purinoceptor 2/3	Homo sapiens		 306							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319869&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397309	384223149							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682874	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C21H20N4O2S/c1-5-8-27-18-10-16(9-17(11-18)21-22-12-14(3)28-21)20(26)23-15(4)19-7-6-13(2)24-25-19/h1,6-7,9-12,15H,8H2,2-4H3,(H,23,26)/t15-/m1/s1	IZIUFNSLLIEWJE-OAHLLOKOSA-N	319870	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 37::US10202369, Example 37::US10472354, Example 37	P2X purinoceptor 2/3	Homo sapiens		 1176							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319870&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397261	384223150							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682876	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C21H17F3N4O2S/c1-4-7-30-16-9-14(8-15(10-16)20-25-11-12(2)31-20)19(29)26-13(3)17-5-6-18(28-27-17)21(22,23)24/h1,5-6,8-11,13H,7H2,2-3H3,(H,26,29)/t13-/m1/s1	PNZFOFJAUOCDQW-CYBMUJFWSA-N	319871	3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- [(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 38::US10202369, Example 38::US10472354, Example 38	P2X purinoceptor 2/3	Homo sapiens		 1145							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319871&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397333	384223151							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682878	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C21H20N4O2S/c1-5-6-27-19-8-16(7-17(9-19)21-24-10-13(2)28-21)20(26)25-14(3)18-11-22-15(4)23-12-18/h1,7-12,14H,6H2,2-4H3,(H,25,26)/t14-/m1/s1	OVENJFXCZONLOP-CQSZACIVSA-N	319872	N-[(1R)-1-(2- Methylpyrimidin- 5-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 39::US10202369, Example 39::US10472354, Example 39	P2X purinoceptor 2/3	Homo sapiens		 1646							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319872&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397588	384223152							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682880	CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H19F3N4O2S/c1-4-5-6-31-18-8-15(7-16(9-18)20-26-10-13(2)32-20)19(30)29-14(3)17-11-27-21(28-12-17)22(23,24)25/h7-12,14H,6H2,1-3H3,(H,29,30)/t14-/m1/s1	XSZOYFWYESZINQ-CQSZACIVSA-N	319873	3-(But-2-yn-1- yloxy)-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 40::US10202369, Example 40::US10472354, Example 40	P2X purinoceptor 2/3	Homo sapiens		 383							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319873&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397357	384223153							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682882	CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1nnc(C)s1	InChI=1S/C20H20N4O2S2/c1-5-6-7-26-17-9-15(8-16(10-17)20-21-11-12(2)27-20)18(25)22-13(3)19-24-23-14(4)28-19/h8-11,13H,7H2,1-4H3,(H,22,25)/t13-/m1/s1	ORWZAOZYNYEGDS-CYBMUJFWSA-N	319874	3-(But-2-yn-1- yloxy)-N-[(1R)- 1-(5-methyl- 1,3,4- thiadiazol-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 41::US10202369, Example 41::US10472354, Example 41	P2X purinoceptor 2/3	Homo sapiens		 1592							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319874&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397286	384223154							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682884	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C21H22N4O3S/c1-12-7-23-19(9-22-12)14(3)25-20(26)15-4-16(21-24-8-13(2)29-21)6-17(5-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,25,26)/t14-/m1/s1	AWWAAAATSKEOQH-CQSZACIVSA-N	319875	N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 42::US10202369, Example 42::US10472354, Example 42	P2X purinoceptor 2/3	Homo sapiens		 1565							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319875&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397394	384223155							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682886	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C21H22N4O3S/c1-12-7-24-21(29-12)16-4-15(5-18(6-16)28-19-10-27-11-19)20(26)25-13(2)17-8-22-14(3)23-9-17/h4-9,13,19H,10-11H2,1-3H3,(H,25,26)/t13-/m1/s1	QZYMXYIOESSIBG-CYBMUJFWSA-N	319876	N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 43::US10202369, Example 43::US10472354, Example 43	P2X purinoceptor 2/3	Homo sapiens		 2688							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319876&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397750	384223156							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682888	CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(23)6-15(22)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27)	DXVSMJSLGFWBSV-UHFFFAOYSA-N	319877	N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 44::US10202369, Example 44::US10472354, Example 44	P2X purinoceptor 2/3	Homo sapiens		 370							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319877&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397182	384223157							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682890	Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C20H20N4O3S/c1-12-3-4-16(24-23-12)9-21-19(25)14-5-15(20-22-8-13(2)28-20)7-17(6-14)27-18-10-26-11-18/h3-8,18H,9-11H2,1-2H3,(H,21,25)	AFIPEIBYSBBLBJ-UHFFFAOYSA-N	319878	N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 45::US10202369, Example 45::US10472354, Example 45	P2X purinoceptor 2/3	Homo sapiens		 1510							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319878&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397740	384223158							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682892	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1	InChI=1S/C21H20ClN3O3S/c1-12-8-24-21(29-12)15-5-14(6-17(7-15)28-18-10-27-11-18)20(26)25-13(2)19-4-3-16(22)9-23-19/h3-9,13,18H,10-11H2,1-2H3,(H,25,26)/t13-/m1/s1	FFCGGIUVAQWIMW-CYBMUJFWSA-N	319879	N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 46::US10202369, Example 46::US10472354, Example 46	P2X purinoceptor 2/3	Homo sapiens		 389							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319879&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397660	384223159							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682894	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C21H22N4O3S/c1-12-4-5-19(25-24-12)14(3)23-20(26)15-6-16(21-22-9-13(2)29-21)8-17(7-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,23,26)/t14-/m1/s1	HFDOVXXFUCEVBK-CQSZACIVSA-N	319880	N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 47::US10202369, Example 47::US10472354, Example 47	P2X purinoceptor 2/3	Homo sapiens		 621							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319880&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397352	384223160							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682896	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H19F3N4O3S/c1-11-6-25-19(32-11)14-3-13(4-16(5-14)31-17-9-30-10-17)18(29)28-12(2)15-7-26-20(27-8-15)21(22,23)24/h3-8,12,17H,9-10H2,1-2H3,(H,28,29)/t12-/m1/s1	HXNSKECKPLVRIH-GFCCVEGCSA-N	319881	3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 48::US10202369, Example 48::US10472354, Example 48	P2X purinoceptor 2/3	Homo sapiens		 451							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319881&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397291	384223161							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682898	CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(22)6-15(23)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27)	FNMVOFQACWEVTO-UHFFFAOYSA-N	319882	N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 49::US10202369, Example 49::US10472354, Example 49	P2X purinoceptor 2/3	Homo sapiens		 1525							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319882&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397320	384223162							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682900	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1	InChI=1S/C19H20N4O3S2/c1-10-7-20-19(27-10)14-4-13(5-15(6-14)26-16-8-25-9-16)17(24)21-11(2)18-23-22-12(3)28-18/h4-7,11,16H,8-9H2,1-3H3,(H,21,24)/t11-/m1/s1	RQBQZBLVECLWLL-LLVKDONJSA-N	319883	N-[(1R)-1-(5-Methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 50::US10202369, Example 50	P2X purinoceptor 2/3	Homo sapiens		 982							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319883	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319883&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397179	384223163							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682902	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C22H23N3O3S/c1-13-4-5-16(10-23-13)15(3)25-21(26)17-6-18(22-24-9-14(2)29-22)8-19(7-17)28-20-11-27-12-20/h4-10,15,20H,11-12H2,1-3H3,(H,25,26)/t15-/m1/s1	MHQNYPHPPSGTBD-OAHLLOKOSA-N	319884	N-[(1R)-1-(6-methylpyridin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 51::US10202369, Example 51	P2X purinoceptor 2/3	Homo sapiens		 1389							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319884&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397804	384223164							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682904	Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F	InChI=1S/C20H17F3N4O3S/c1-11-7-25-19(31-11)13-4-12(5-15(6-13)30-16-9-29-10-16)18(28)24-8-14-2-3-17(27-26-14)20(21,22)23/h2-7,16H,8-10H2,1H3,(H,24,28)	KTKYNBLLOZOZPY-UHFFFAOYSA-N	319885	3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N-{[6- (trifluoromethyl) pyridazin-3- yl]methyl} benzamide::US10174016, Example 52::US10202369, Example 52::US10472354, Example 52	P2X purinoceptor 2/3	Homo sapiens		 564							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319885&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397650	384223165							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682906	CC[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-3-18(15-8-27-21(28-9-15)22(23,24)25)29-19(30)13-4-14(20-26-7-12(2)33-20)6-16(5-13)32-17-10-31-11-17/h4-9,17-18H,3,10-11H2,1-2H3,(H,29,30)/t18-/m1/s1	PHCWFMJDVHAVQT-GOSISDBHSA-N	319886	3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N- [(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]propyl] benzamide::US10174016, Example 53::US10202369, Example 53::US10472354, Example 53	P2X purinoceptor 2/3	Homo sapiens		 2740							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319886&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397526	384223166							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682908	Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m0/s1	IFCRFQDQDLUKDL-IBGZPJMESA-N	319887	N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 54::US10202369, Example 54::US10472354, Example 54	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319887&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397485	384223167							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682910	Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ncc(Cl)cc1F	InChI=1S/C22H21ClFN3O3S/c1-13-9-27-22(31-13)15-5-14(6-18(7-15)30-12-17-3-2-4-29-17)21(28)26-11-20-19(24)8-16(23)10-25-20/h5-10,17H,2-4,11-12H2,1H3,(H,26,28)/t17-/m0/s1	UTQWAUZOCBGCBP-KRWDZBQOSA-N	322243	US10183937, Example 55::US10202369, Example 55	P2X purinoceptor 2/3	Homo sapiens		 325							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322243&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397391	384225320							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682912	Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-14-9-24-18(11-23-14)12-25-21(27)16-6-17(22-26-10-15(2)30-22)8-20(7-16)29-13-19-4-3-5-28-19/h6-11,19H,3-5,12-13H2,1-2H3,(H,25,27)/t19-/m0/s1	UMCJOKLDVAQWOA-IBGZPJMESA-N	319889	N-[(5-Methylpyrazin-2-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 56::US10202369, Example 56	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319889	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319889&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397398	384223169							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682914	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19+/m1/s1	MANPQCKCYFRFOG-APWZRJJASA-N	319890	N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 57::US10202369, Example 57::US10472354, Example 57	P2X purinoceptor 2/3	Homo sapiens		 2840							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319890&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397390	384223170							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682916	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18+/m1/s1	MXZPUDRHAAYJOR-KDOFPFPSSA-N	319891	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 58::US10202369, Example 58::US10472354, Example 58	P2X purinoceptor 2/3	Homo sapiens		 461							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319891&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397134	384223171							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682918	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19+/m1/s1	JHPJVAOLQKHAFN-APWZRJJASA-N	319892	N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 59::US10202369, Example 59::US10472354, Example 59	P2X purinoceptor 2/3	Homo sapiens		 507							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319892&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397721	384223172							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682920	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-11-27-22(34-13)16-8-15(9-18(10-16)33-12-17-4-3-7-32-17)21(31)28-14(2)19-5-6-20(30-29-19)23(24,25)26/h5-6,8-11,14,17H,3-4,7,12H2,1-2H3,(H,28,31)/t14-,17+/m1/s1	KNJYTDFISMIFTK-PBHICJAKSA-N	319893	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 60::US10202369, Example 60::US10472354, Example 60	P2X purinoceptor 2/3	Homo sapiens		 578							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319893&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397124	384223173							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682922	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19-/m1/s1	JHPJVAOLQKHAFN-VQIMIIECSA-N	319894	N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 61::US10202369, Example 61::US10472354, Example 61	P2X purinoceptor 2/3	Homo sapiens		 428							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319894&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397475	384223174							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682924	Cc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m1/s1	IFCRFQDQDLUKDL-LJQANCHMSA-N	319895	N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 62::US10202369, Example 62::US10472354, Example 62	P2X purinoceptor 2/3	Homo sapiens		 1436							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319895&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397725	384223175							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
682926	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18-/m1/s1	MXZPUDRHAAYJOR-RDTXWAMCSA-N	319896	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 63::US10202369, Example 63::US10472354, Example 63	P2X purinoceptor 2/3	Homo sapiens		 118							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319896&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397292	384223176							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683456	C[C@@H](NC(=O)c1cc(OCC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H25F3N4O2S/c1-13-9-27-20(33-13)16-6-15(7-18(8-16)32-12-22(3,4)5)19(31)30-14(2)17-10-28-21(29-11-17)23(24,25)26/h6-11,14H,12H2,1-5H3,(H,30,31)/t14-/m1/s1	CYTLZVKLWUDWCI-CQSZACIVSA-N	322517	3-(2-hydroxy-2- methylpropoxy)-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10183937, Example 328::US10202369, Example 328	P2X purinoceptor 2/3	Homo sapiens		 274							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322517	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322517&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338448	384225579							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683458	C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1	LFYNTNZWPQXJEM-NKTHEXPSSA-N	320162	3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332	P2X purinoceptor 2/3	Homo sapiens		 120							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397698	384223436							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683460	C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1	LFYNTNZWPQXJEM-NKTHEXPSSA-N	320162	3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332	P2X purinoceptor 2/3	Homo sapiens		 170							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397698	384223436							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683462	C[C@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m0/s1	LFYNTNZWPQXJEM-NGMICRHFSA-N	322520	US10183937, Example 331::US10202369, Example 331	P2X purinoceptor 2/3	Homo sapiens		 191							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322520	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322520&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375412	384225582							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683464	C[C@@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1	FUZHKJYNGBDBHI-NKTHEXPSSA-N	320165	3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Diastereoisomers::US10174016, Example 332::US10202369, Example 333	P2X purinoceptor 2/3	Homo sapiens		 174							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320165&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397763	384223439							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683466	C[C@@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1	FUZHKJYNGBDBHI-NKTHEXPSSA-N	320165	3-[(3-methyltetrahydrofuran-3-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Diastereoisomers::US10174016, Example 332::US10202369, Example 333	P2X purinoceptor 2/3	Homo sapiens		 122							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320165	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320165&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397763	384223439							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683468	C[C@H](NC(=O)c1cc(OCC2(C)CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-9-28-21(35-14)17-6-16(7-19(8-17)34-13-23(3)4-5-33-12-23)20(32)31-15(2)18-10-29-22(30-11-18)24(25,26)27/h6-11,15H,4-5,12-13H2,1-3H3,(H,31,32)/t15-,23?/m0/s1	FUZHKJYNGBDBHI-NGMICRHFSA-N	322523	US10183937, Example 334::US10202369, Example 334	P2X purinoceptor 2/3	Homo sapiens		 132							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322523	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322523&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375413	384225584							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683470	C[C@@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m1/s1	CGMVCPWOPCCFBE-IKJXHCRLSA-N	320168	3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 335::US10202369, Example 336::US10472354, Example 335	P2X purinoceptor 2/3	Homo sapiens		 541							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320168&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397147	384223442							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683472	C[C@@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m1/s1	CGMVCPWOPCCFBE-IKJXHCRLSA-N	320168	3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 335::US10202369, Example 336::US10472354, Example 335	P2X purinoceptor 2/3	Homo sapiens		 443							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320168&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397147	384223442							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683474	C[C@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m0/s1	CGMVCPWOPCCFBE-PIVQAISJSA-N	322526	US10183937, Example 337::US10202369, Example 337	P2X purinoceptor 2/3	Homo sapiens		 257							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322526	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322526&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375414	384225586							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683476	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1	FSGDRFBLPAILDE-IYXRBSQSSA-N	319995	3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338	P2X purinoceptor 2/3	Homo sapiens		 72.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397269	384223275							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683478	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1	FSGDRFBLPAILDE-IYXRBSQSSA-N	319995	3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338	P2X purinoceptor 2/3	Homo sapiens		 251							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397269	384223275							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683480	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m0/s1	FSGDRFBLPAILDE-HSBZDZAISA-N	319996	US10174016, Example 163::US10202369, Example 340::US10472354, Example 162	P2X purinoceptor 2/3	Homo sapiens		 103							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319996&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134328174	384223276							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683482	C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1	UOQSAFNLRPUQCS-DSXPMEPHSA-N	320174	3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343	P2X purinoceptor 2/3	Homo sapiens		 1242							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397140	384223447							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683484	C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1	UOQSAFNLRPUQCS-DSXPMEPHSA-N	320174	3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343	P2X purinoceptor 2/3	Homo sapiens		 1892							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397140	384223447							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683486	C[C@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m0/s1	UOQSAFNLRPUQCS-LONTXVJRSA-N	320176	US10174016, Example 343::US10202369, Example 343	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320176	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320176&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374917	384223449							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683488	CC(C)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O3S/c1-15(2)36-11-21-13-38-14-22(12-36)24(21)39-23-6-18(5-19(7-23)26-32-8-16(3)40-26)25(37)35-17(4)20-9-33-27(34-10-20)28(29,30)31/h5-10,15,17,21-22,24H,11-14H2,1-4H3,(H,35,37)/t17-,21?,22?,24?/m1/s1	IQKMSJWJAJKSIQ-CBDSMJNHSA-N	320177	3-[(7-isopropyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two stereoisomers::US10174016, Example 344::US10202369, Example 344::US10472354, Example 344	P2X purinoceptor 2/3	Homo sapiens		 987							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320177&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397285	384223450							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683490	COC(=O)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C27H28F3N5O5S/c1-14-7-31-24(41-14)17-4-16(23(36)34-15(2)18-8-32-25(33-9-18)27(28,29)30)5-21(6-17)40-22-19-10-35(26(37)38-3)11-20(22)13-39-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,34,36)/t15-,19?,20?,22?/m1/s1	GHSFQGHMPBJNHK-DSXPMEPHSA-N	320178	US10174016, Example 345::US10202369, Example 345::methyl 9-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]-3-oxa-7-azabicycle[3.3.1]nonane-7-carboxylate, as a mixture of two stereoisomers	P2X purinoceptor 2/3	Homo sapiens		 99.0							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320178	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320178&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397363	384223451							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683492	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22-/m1/s1	OEKUZTDVCYAZBS-VGOFRKELSA-N	320179	Tert-butyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 346::US10202369, Example 346::US10472354, Example 346	P2X purinoceptor 2/3	Homo sapiens		 334							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320179&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338449	384223452							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683494	C[C@@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19-/m1/s1	HRVUBTPQOQIHTK-AUUYWEPGSA-N	320180	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 347::US10202369, Example 347::US10472354, Example 347	P2X purinoceptor 2/3	Homo sapiens		 1521							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320180&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397601	384223453							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683496	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m1/s1	MROBUJILSMBILX-FOIQADDNSA-N	320181	3-{[(2R)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 348::US10202369, Example 348::US10472354, Example 348	P2X purinoceptor 2/3	Homo sapiens		 760							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320181&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397607	384223454							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683498	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m1/s1	OEKUZTDVCYAZBS-VGSWGCGISA-N	320182	Tert-butyl (2S)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 349::US10202369, Example 349::US10472354, Example 349	P2X purinoceptor 2/3	Homo sapiens		 545							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320182&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338450	384223455							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683500	C[C@@H](NC(=O)c1cc(OC[C@@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m1/s1	HRVUBTPQOQIHTK-KUHUBIRLSA-N	320183	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 350::US10202369, Example 350::US10472354, Example 350	P2X purinoceptor 2/3	Homo sapiens		 1162							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320183&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397343	384223456							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683502	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m1/s1	MROBUJILSMBILX-QRWLVFNGSA-N	320184	3-{[(2S)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 351::US10202369, Example 351::US10472354, Example 351	P2X purinoceptor 2/3	Homo sapiens		 690							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320184&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397379	384223457							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683504	C[C@@H](NC(=O)c1cc(OCC2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19?/m1/s1	HRVUBTPQOQIHTK-MJTSIZKDSA-N	320185	3-(5-Methyl-1,3-thiazol-2-yl)-5-[morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, Formed as a Mixture of Example 347 (Diastereoisomer 1) and Example 350 (Diastereoisomer 2)::US10174016, Example 352::US10202369, Example 352::US10472354, Example 352	P2X purinoceptor 2/3	Homo sapiens		 1139							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320185&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397625	384223458							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683506	C[C@@H](NC(=O)c1cc(OCC2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20?/m1/s1	MROBUJILSMBILX-IWPPFLRJSA-N	320186	3-{[4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, formed as a mixture of Example 348 (Diastereoisomer 2) and Example 351 (Diastereoisomer 1)::US10174016, Example 353::US10202369, Example 353::US10472354, Example 353	P2X purinoceptor 2/3	Homo sapiens		 427							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320186&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397299	384223459							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683508	C[C@@H](NC(=O)c1cc(OCC2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23?/m1/s1	KEYDTZMORFCFGJ-NKTHEXPSSA-N	322543	3-(Fluoropiperidin-3-yl)methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 354::US10202369, Example 354	P2X purinoceptor 2/3	Homo sapiens		 1034							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322543	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322543&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338435	384225603							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683510	C[C@H](NC(=O)c1cc(OCC2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23?/m0/s1	KEYDTZMORFCFGJ-NGMICRHFSA-N	322544	US10183937, Example 355::US10202369, Example 355	P2X purinoceptor 2/3	Homo sapiens		 956							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322544	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322544&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375416	384225604							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683512	C[C@@H](NC(=O)c1cc(OCC2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24?/m1/s1	JEEGJUGZAOELQB-YAOANENCSA-N	322545	US10183937, Example 356::US10202369, Example 356	P2X purinoceptor 2/3	Homo sapiens		 643							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322545	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322545&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397155	384225605							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683514	C[C@H](NC(=O)c1cc(OCC2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24?/m0/s1	JEEGJUGZAOELQB-FXIRQEPWSA-N	322546	US10183937, Example 357::US10202369, Example 357	P2X purinoceptor 2/3	Homo sapiens		 310							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322546	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322546&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375417	384225606							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683516	C[C@@H](NC(=O)c1cc(OCC2(F)CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F4N5O2S/c1-12-6-28-19(34-12)15-3-14(4-17(5-15)33-11-21(23)9-27-10-21)18(32)31-13(2)16-7-29-20(30-8-16)22(24,25)26/h3-8,13,27H,9-11H2,1-2H3,(H,31,32)/t13-/m1/s1	BCJGFEUMNVQMPR-CYBMUJFWSA-N	320191	3-[(3- fluoroazetidin- 3-yl)methoxy]- 5-(5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 358::US10202369, Example 358::US10472354, Example 358	P2X purinoceptor 2/3	Homo sapiens		 1441							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320191&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397395	384223464							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683518	C[C@@H](NC(=O)c1cc(OCC2CNCCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F5N5O2S/c1-13-8-31-21(37-13)16-5-15(6-19(7-16)36-12-18-11-30-4-3-23(18,25)26)20(35)34-14(2)17-9-32-22(33-10-17)24(27,28)29/h5-10,14,18,30H,3-4,11-12H2,1-2H3,(H,34,35)/t14-,18?/m1/s1	GMFUIUUSPXQCGC-IKJXHCRLSA-N	320192	3-{[4,4- difluoropiperidin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 359::US10202369, Example 359::US10472354, Example 359	P2X purinoceptor 2/3	Homo sapiens		 200							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320192&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397568	384223465							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
683520	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1	QQIYVSYWBHUFSE-DNVCBOLYSA-N	320193	3-{[(3R)-4-methylmorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 360::US10202369, Example 360::US10472354, Example 360	P2X purinoceptor 2/3	Homo sapiens		 455							US Patent		10.7270/Q2TT4T2P		aid1797299	US10202369	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320193&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397664	384223466							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
50952194	COc1ccc(cc1)C(=O)C1=C(O)C(=O)N(C1C1CCCCC1)c1ccc(cc1)-c1ccon1	InChI=1S/C27H26N2O5/c1-33-21-13-9-19(10-14-21)25(30)23-24(18-5-3-2-4-6-18)29(27(32)26(23)31)20-11-7-17(8-12-20)22-15-16-34-28-22/h7-16,18,24,31H,2-6H2,1H3	VVVNQMHFXWAMBD-UHFFFAOYSA-N	50274365	CHEMBL4127637	P2X purinoceptor 2/3	Homo sapiens		 4320							ChEMBL	10.1016/j.bmcl.2017.04.060	10.7270/Q2W95CP6	29805055			Tobinaga, H; Kameyama, T; Oohara, M; Kobayashi, N; Ohdan, M; Ishizuka, N; Kume, M; Tomari, M; Tanaka, Y; Takahashi, F; Kinoshita, H; Shimada, S; Shinohara, S; Kai, H	Shionogi & Co., Ltd	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50274365	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50274365&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			145960885	405256876							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843171	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21-/m1/s1	PQZKBUDIGDWISA-IIBYNOLFSA-N	320199	3-{[(2R)-4-methylmorpholin-2-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}benzamide::US10174016, Example 366::US10202369, Example 366::US10472354, Example 366	P2X purinoceptor 2/3	Homo sapiens		 977							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320199	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320199&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397655	384223472							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843173	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18-/m1/s1	AJIHXKQJGQMCEX-FZKQIMNGSA-N	320200	3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 367::US10202369, Example 367::US10472354, Example 367	P2X purinoceptor 2/3	Homo sapiens		 506							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320200&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397149	384223473							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843175	CN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1	InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m0/s1	VTYFKUULJMRVCQ-IBGZPJMESA-N	320201	3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 368::US10202369, Example 368::US10472354, Example 368	P2X purinoceptor 2/3	Homo sapiens		 1094							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320201	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320201&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397462	384223474							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843177	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F	InChI=1S/C25H28F2N4O3S/c1-15-11-29-25(35-15)19-8-18(9-20(10-19)34-14-21-13-31(3)6-7-33-21)24(32)30-16(2)17-4-5-22(23(26)27)28-12-17/h4-5,8-12,16,21,23H,6-7,13-14H2,1-3H3,(H,30,32)/t16-,21-/m1/s1	YEIOEBIHIRXRPN-IIBYNOLFSA-N	320202	N-{(1R)-1-[6- (difluoromethyl) pyridin-3- yl]ethyl}-3- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 369::US10202369, Example 369::US10472354, Example 369	P2X purinoceptor 2/3	Homo sapiens		 328							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320202	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320202&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397220	384223475							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843179	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-20(10-19)35-14-21-13-32(3)6-7-34-21)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,21H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,21+/m1/s1	PQZKBUDIGDWISA-IERDGZPVSA-N	320203	3-{[(2S)-4- methylmorpholin 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 370::US10202369, Example 370::US10472354, Example 370	P2X purinoceptor 2/3	Homo sapiens		 1007							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320203	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320203&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397778	384223476							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843181	C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F4N5O2S/c1-13-7-28-20(35-13)16-4-15(5-18(6-16)34-12-22(24)10-32(3)11-22)19(33)31-14(2)17-8-29-21(30-9-17)23(25,26)27/h4-9,14H,10-12H2,1-3H3,(H,31,33)/t14-/m1/s1	UHPSIXSPUGVYFA-CQSZACIVSA-N	320204	3-[(3-fluoro-1- methylazetidin-3- yl}methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 371::US10202369, Example 371::US10472354, Example 371	P2X purinoceptor 2/3	Homo sapiens		 1173							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320204	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320204&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397234	384223477							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843183	CN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)NCc2cnc(nc2)C(F)(F)F)C1	InChI=1S/C23H24F3N5O3S/c1-14-8-28-21(35-14)17-5-16(6-18(7-17)34-13-19-12-31(2)3-4-33-19)20(32)27-9-15-10-29-22(30-11-15)23(24,25)26/h5-8,10-11,19H,3-4,9,12-13H2,1-2H3,(H,27,32)/t19-/m1/s1	VTYFKUULJMRVCQ-LJQANCHMSA-N	320205	3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{[2- (trifluoromethyl) pyrimidin-5-yl] methyl} benzamide::US10174016, Example 372::US10202369, Example 372::US10472354, Example 372	P2X purinoceptor 2/3	Homo sapiens		 1211							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320205	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320205&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397797	384223478							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843185	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19-/m1/s1	IJFKDPNABTXGCF-DNVCBOLYSA-N	320206	3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 373::US10202369, Example 373::US10472354, Example 373	P2X purinoceptor 2/3	Homo sapiens		 2827							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320206	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320206&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397505	384223479							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843187	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19+/m1/s1	IJFKDPNABTXGCF-BEFAXECRSA-N	320207	3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 374::US10202369, Example 374::US10472354, Example 374	P2X purinoceptor 2/3	Homo sapiens		 2557							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320207	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320207&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397406	384223480							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843189	CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20+/m1/s1	PEGAFCGSQABLTK-QRWLVFNGSA-N	320208	3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methylmorpholin- 2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 375::US10202369, Example 375::US10472354, Example 375	P2X purinoceptor 2/3	Homo sapiens		 185							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320208	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320208&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397736	384223481							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843191	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23ClF3N5O3S/c1-13(16-8-29-22(30-9-16)23(25,26)27)31-20(33)14-5-15(21-28-10-19(24)36-21)7-17(6-14)35-12-18-11-32(2)3-4-34-18/h5-10,13,18H,3-4,11-12H2,1-2H3,(H,31,33)/t13-,18+/m1/s1	AJIHXKQJGQMCEX-ACJLOTCBSA-N	320209	3-(5-chloro- 1,3-thiazol-2- yl)-5-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 376::US10202369, Example 376::US10472354, Example 376	P2X purinoceptor 2/3	Homo sapiens		 898							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320209	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320209&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397674	384223482							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843193	CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H28F3N5O3S/c1-4-21-12-29-23(37-21)17-7-16(8-19(9-17)36-14-20-13-33(3)5-6-35-20)22(34)32-15(2)18-10-30-24(31-11-18)25(26,27)28/h7-12,15,20H,4-6,13-14H2,1-3H3,(H,32,34)/t15-,20-/m1/s1	PEGAFCGSQABLTK-FOIQADDNSA-N	320210	3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methylmorpholin- 2-yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 377::US10202369, Example 377::US10472354, Example 377	P2X purinoceptor 2/3	Homo sapiens		 273							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320210	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320210&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397144	384223483							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843195	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1	TYUJHJGDOVFFQY-BEFAXECRSA-N	320211	3-{[(2S)-1- methylpyrrolidin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 378::US10202369, Example 378::US10472354, Example 378	P2X purinoceptor 2/3	Homo sapiens		 3752							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320211	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320211&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397183	384223484							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843197	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-13-19-5-4-6-32(19)3)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1	TYUJHJGDOVFFQY-DNVCBOLYSA-N	320212	3-{[(2R)-1- methylpyrrolidin- 2-yl]methoxy}-5 (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 379::US10202369, Example 379::US10472354, Example 379	P2X purinoceptor 2/3	Homo sapiens		 2755							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320212	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320212&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397315	384223485							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843199	C[C@@H](NC(=O)c1cc(OCC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H28F3N5O2S/c1-15-11-29-23(36-15)19-8-18(9-21(10-19)35-14-17-4-6-33(3)7-5-17)22(34)32-16(2)20-12-30-24(31-13-20)25(26,27)28/h8-13,16-17H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1	GQMGTASPVLCRIR-MRXNPFEDSA-N	320213	3-[(1- methylpiperidin- 4-yl)methoxy]-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 380::US10202369, Example 380::US10472354, Example 380	P2X purinoceptor 2/3	Homo sapiens		 2880							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320213	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320213&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397264	384223486							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843201	CC(C)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22-/m1/s1	AOHBYHNFISDLHQ-VGOFRKELSA-N	320214	3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 381::US10202369, Example 381::US10472354, Example 381	P2X purinoceptor 2/3	Homo sapiens		 954							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320214	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320214&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397576	384223487							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843203	CC(C)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C26H30F3N5O3S/c1-15(2)34-5-6-36-22(13-34)14-37-21-8-18(7-19(9-21)24-30-10-16(3)38-24)23(35)33-17(4)20-11-31-25(32-12-20)26(27,28)29/h7-12,15,17,22H,5-6,13-14H2,1-4H3,(H,33,35)/t17-,22+/m1/s1	AOHBYHNFISDLHQ-VGSWGCGISA-N	320215	3-(5-methyl- 1,3-thiazol-2- yl)-5-{[(2R)-4- (propan-2- yl)morpholin- 2-yl]methoxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 382::US10202369, Example 382::US10472354, Example 382	P2X purinoceptor 2/3	Homo sapiens		 432							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320215	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320215&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397421	384223488							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843205	C[C@@H](NC(=O)c1cc(OCC2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19?/m1/s1	LGPVNMAGAZJDEW-NYRJJRHWSA-N	320216	3-{[4,4- difluoro-1- methylpiperidin- 3-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 383::US10202369, Example 384::US10472354, Example 383	P2X purinoceptor 2/3	Homo sapiens		 35.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320216	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320216&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397497	384223489							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843207	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19-/m1/s1	LGPVNMAGAZJDEW-DNVCBOLYSA-N	420323	US10472354, Example 384	P2X purinoceptor 2/3	Homo sapiens		 75.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420323	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420323&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search											2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843209	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-9-31-22(38-14)17-6-16(7-20(8-17)37-13-19-12-35(3)5-4-24(19,26)27)21(36)34-15(2)18-10-32-23(33-11-18)25(28,29)30/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,34,36)/t15-,19+/m1/s1	LGPVNMAGAZJDEW-BEFAXECRSA-N	320217	3-{[4,4-difluoro-1-methylpiperidin-3-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 384::US10174016, Example 385::US10472354, Example 385	P2X purinoceptor 2/3	Homo sapiens		 28.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320217	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320217&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374922	384223490							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843211	C[C@@H](NC(=O)c1cc(OCC2(F)CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C24H24F4N4O2S/c1-14-9-30-22(35-14)18-6-17(7-19(8-18)34-13-23(25)11-32(3)12-23)21(33)31-15(2)16-4-5-20(29-10-16)24(26,27)28/h4-10,15H,11-13H2,1-3H3,(H,31,33)/t15-/m1/s1	YWRAMSXXAJRPGK-OAHLLOKOSA-N	320219	3-[(3-fluoro-1- methylazetidin-3- yl)methoxy]-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 386::US10202369, Example 386::US10472354, Example 386	P2X purinoceptor 2/3	Homo sapiens		 811							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320219	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320219&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397321	384223491							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843213	CCc1cnc(s1)-c1cc(OCC2(F)CN(C)C2)cc(c1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H26F4N4O2S/c1-4-20-11-31-23(36-20)18-7-17(8-19(9-18)35-14-24(26)12-33(3)13-24)22(34)32-15(2)16-5-6-21(30-10-16)25(27,28)29/h5-11,15H,4,12-14H2,1-3H3,(H,32,34)/t15-/m1/s1	HCTVCZSENAWJEB-OAHLLOKOSA-N	320220	3-(5-ethyl-1,3- thiazol-2-yl)-5-[(3- fluoro-1- methylazetidin-3- yl)methoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl] ethyl}benzamide::US10174016, Example 387::US10202369, Example 387::US10472354, Example 387	P2X purinoceptor 2/3	Homo sapiens		 461							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320220&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397751	384223492							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843215	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18-/m1/s1	SOWWCICJAYGBSY-CRAIPNDOSA-N	320221	3-{[(3R)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 388::US10202369, Example 388::US10472354, Example 388	P2X purinoceptor 2/3	Homo sapiens		 1353							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320221	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320221&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397768	384223493							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843217	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-19(10-17)35-13-18-12-34-7-6-32(18)3)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,18H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,18+/m1/s1	SOWWCICJAYGBSY-QAPCUYQASA-N	320222	3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 389::US10202369, Example 389::US10472354, Example 389	P2X purinoceptor 2/3	Homo sapiens		 1614							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320222	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320222&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397449	384223494							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843219	CCN1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21-/m1/s1	IJXNJADLTIUKEL-IIBYNOLFSA-N	320223	3-{[(2R)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 390::US10202369, Example 390::US10472354, Example 390	P2X purinoceptor 2/3	Homo sapiens		 804							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320223	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320223&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397822	384223495							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843221	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CC(F)F)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O3S/c1-14-8-31-23(39-14)17-5-16(22(36)34-15(2)18-9-32-24(33-10-18)25(28,29)30)6-19(7-17)38-13-20-11-35(3-4-37-20)12-21(26)27/h5-10,15,20-21H,3-4,11-13H2,1-2H3,(H,34,36)/t15-,20-/m1/s1	LANXVVYUHZPONS-FOIQADDNSA-N	320224	3-{[(2R)-4-(2,2-difluoroethyl)morpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 391::US10202369, Example 391::US10472354, Example 391	P2X purinoceptor 2/3	Homo sapiens		 840							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320224	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320224&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397746	384223496							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843223	COC(=O)N1CCO[C@@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20-/m1/s1	AMNDVZJYNBRGRX-FOIQADDNSA-N	320225	Methyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 392::US10202369, Example 392::US10472354, Example 392	P2X purinoceptor 2/3	Homo sapiens		 411							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320225	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320225&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338451	384223497							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843225	COC(=O)N1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C25H26F3N5O5S/c1-14-9-29-22(39-14)17-6-16(21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28)7-19(8-17)38-13-20-12-33(4-5-37-20)24(35)36-3/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,32,34)/t15-,20+/m1/s1	AMNDVZJYNBRGRX-QRWLVFNGSA-N	320226	Methyl (2S)-2- {[3-(5-methyl- 1,3-thiazol-2- yl)-5-({(1R)-1- [2- (trifluoromethyl) pyrimidin-5-yl] ethyl}carbamoyl) phenoxy]methyl} morpholine-4- carboxylate::US10174016, Example 393::US10202369, Example 393::US10472354, Example 393	P2X purinoceptor 2/3	Homo sapiens		 1033							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320226	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320226&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338452	384223498							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843227	C[C@@H](NC(=O)c1cc(OCC2CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H22F3N5O2S/c1-12-6-27-20(33-12)16-3-15(4-18(5-16)32-11-14-7-26-8-14)19(31)30-13(2)17-9-28-21(29-10-17)22(23,24)25/h3-6,9-10,13-14,26H,7-8,11H2,1-2H3,(H,30,31)/t13-/m1/s1	MHYFOJHMKOGSKR-CYBMUJFWSA-N	320227	3-(Azetidin-3-ylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 394::US10202369, Example 394::US10472354, Example 394	P2X purinoceptor 2/3	Homo sapiens		 3983							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320227	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320227&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397376	384223499							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843229	C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1	SDFLFPYVVNTAIN-RDTXWAMCSA-N	320228	3-{[(3R)-4-methyl-5-oxomorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 395::US10202369, Example 395::US10472354, Example 395	P2X purinoceptor 2/3	Homo sapiens		 1312							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320228	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320228&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397767	384223500							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843231	C[C@@H](NC(=O)c1cc(OC[C@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17-/m1/s1	QBCIMXIDQXCQLC-CXAGYDPISA-N	320229	3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3R)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 396::US10202369, Example 396::US10472354, Example 396	P2X purinoceptor 2/3	Homo sapiens		 1803							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320229	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320229&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397733	384223501							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843233	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18+/m1/s1	OAEQMLBAMDEFGR-ACJLOTCBSA-N	320230	3-{[(5S)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 397::US10202369, Example 397::US10472354, Example 397	P2X purinoceptor 2/3	Homo sapiens		 1362							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320230	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320230&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397304	384223502							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843235	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-7-27-20(36-12)15-4-14(5-17(6-15)34-11-18-10-31(3)22(33)35-18)19(32)30-13(2)16-8-28-21(29-9-16)23(24,25)26/h4-9,13,18H,10-11H2,1-3H3,(H,30,32)/t13-,18-/m1/s1	OAEQMLBAMDEFGR-FZKQIMNGSA-N	320231	3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 398::US10202369, Example 398::US10472354, Example 398	P2X purinoceptor 2/3	Homo sapiens		 1795							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320231	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320231&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397297	384223503							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51215544	Cc1cc(Cl)c(OCCO)cc1NC(=O)C1=CNC(=O)C[C@H]1c1ccc(F)cc1	InChI=1S/C21H20ClFN2O4/c1-12-8-17(22)19(29-7-6-26)10-18(12)25-21(28)16-11-24-20(27)9-15(16)13-2-4-14(23)5-3-13/h2-5,8,10-11,15,26H,6-7,9H2,1H3,(H,24,27)(H,25,28)/t15-/m0/s1	GGNOURYPUNZEOQ-HNNXBMFYSA-N	50499490	CHEMBL3741992	P2X purinoceptor 2/3	Homo sapiens		>10000							ChEMBL	10.1021/acs.jmedchem.5b00365	10.7270/Q2QZ2DZ2	26460788			Lopez-Tapia, F; Walker, KA; Brotherton-Pleiss, C; Caroon, J; Nitzan, D; Lowrie, L; Gleason, S; Zhao, SH; Berger, J; Cockayne, D; Phippard, D; Suttmann, R; Fitch, WL; Bourdet, D; Rege, P; Huang, X; Broadbent, S; Dvorak, C; Zhu, J; Wagner, P; Padilla, F; Loe, B; Jahangir, A; Alker, A	Hoffmann-La Roche, Inc.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50499490	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50499490&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			46832336	433911391							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842441	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O2S/c1-12-8-26-20(32-12)16-5-15(6-18(7-16)31-11-14-3-4-14)19(30)29-13(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,29,30)/t13-/m1/s1	KPIHUQDIFGXEHA-CYBMUJFWSA-N	319834	3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 1::US10202369, Example 1::US10472354, Example 1	P2X purinoceptor 2/3	Homo sapiens		 76.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319834	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319834&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397250	384223114							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842443	Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C21H22N4O2S/c1-13-3-6-18(25-24-13)11-22-20(26)16-7-17(21-23-10-14(2)28-21)9-19(8-16)27-12-15-4-5-15/h3,6-10,15H,4-5,11-12H2,1-2H3,(H,22,26)	LHMIEJIRNSAGER-UHFFFAOYSA-N	319835	3-(Cyclopropylmethoxy)-N-[(6-methylpyridazin-3-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 2::US10202369, Example 2::US10472354, Example 2	P2X purinoceptor 2/3	Homo sapiens		 251							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319835	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319835&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397260	384223115							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842445	Cc1cnc(s1)-c1cc(OCC2CC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C21H22N4O2S/c1-13-8-23-18(10-22-13)11-24-20(26)16-5-17(21-25-9-14(2)28-21)7-19(6-16)27-12-15-3-4-15/h5-10,15H,3-4,11-12H2,1-2H3,(H,24,26)	SHCAJJQUYCQWRM-UHFFFAOYSA-N	319836	3-(Cyclopropylmethoxy)-N-[(5-methylpyrazin-2-yl)methyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 3::US10202369, Example 3::US10472354, Example 3	P2X purinoceptor 2/3	Homo sapiens		 1106							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319836	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319836&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397194	384223116							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842447	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C22H24N4O2S/c1-13-9-24-20(11-23-13)15(3)26-21(27)17-6-18(22-25-10-14(2)29-22)8-19(7-17)28-12-16-4-5-16/h6-11,15-16H,4-5,12H2,1-3H3,(H,26,27)/t15-/m1/s1	DYWYLXQLERQEEM-OAHLLOKOSA-N	319837	3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 4::US10202369, Example 4::US10472354, Example 4	P2X purinoceptor 2/3	Homo sapiens		 98.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319837	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319837&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397428	384223117							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842449	CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(23)8-17(24)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28)	CGCJNRQFWMKWFU-UHFFFAOYSA-N	319838	N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 5::US10202369, Example 5::US10472354, Example 5	P2X purinoceptor 2/3	Homo sapiens		 346							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319838	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319838&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397491	384223118							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842451	CC(NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C22H21ClFN3O2S/c1-12-9-26-22(30-12)16-5-15(6-18(7-16)29-11-14-3-4-14)21(28)27-13(2)20-19(24)8-17(23)10-25-20/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,28)	YIPUFXDTAKNGSX-UHFFFAOYSA-N	319839	N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 6::US10202369, Example 6::US10472354, Example 6	P2X purinoceptor 2/3	Homo sapiens		 38.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319839	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319839&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397488	384223119							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842453	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1	InChI=1S/C20H22N4O2S2/c1-11-9-21-20(27-11)16-6-15(7-17(8-16)26-10-14-4-5-14)18(25)22-12(2)19-24-23-13(3)28-19/h6-9,12,14H,4-5,10H2,1-3H3,(H,22,25)/t12-/m1/s1	QOCVVHCSVZQPAR-GFCCVEGCSA-N	319840	3-(Cyclopropylmethoxy)-N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 7::US10202369, Example 7::US10472354, Example 7	P2X purinoceptor 2/3	Homo sapiens		 106							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319840	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319840&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397154	384223120							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842455	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C22H24N4O2S/c1-13-4-7-20(26-25-13)15(3)24-21(27)17-8-18(22-23-11-14(2)29-22)10-19(9-17)28-12-16-5-6-16/h4,7-11,15-16H,5-6,12H2,1-3H3,(H,24,27)/t15-/m1/s1	ZZPHBEIBURIANJ-OAHLLOKOSA-N	319841	3-(Cyclopropylmethoxy)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 8::US10202369, Example 8::US10472354, Example 8	P2X purinoceptor 2/3	Homo sapiens		 90.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319841	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319841&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397204	384223121							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842457	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H21F3N4O2S/c1-12-10-26-21(32-12)16-7-15(8-17(9-16)31-11-14-3-4-14)20(30)27-13(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,13-14H,3-4,11H2,1-2H3,(H,27,30)/t13-/m1/s1	FDEHTNMFMQMRCT-CYBMUJFWSA-N	319842	3-(Cyclopropylmethoxy)-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 9::US10202369, Example 9::US10472354, Example 9	P2X purinoceptor 2/3	Homo sapiens		 145							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319842	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319842&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397573	384223122							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842459	C[C@@H](NC(=O)c1cc(OCC2CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C22H24N4O2S/c1-13-9-25-22(29-13)18-6-17(7-20(8-18)28-12-16-4-5-16)21(27)26-14(2)19-10-23-15(3)24-11-19/h6-11,14,16H,4-5,12H2,1-3H3,(H,26,27)/t14-/m1/s1	HEHYSAYIHLPEGC-CQSZACIVSA-N	319843	3-(Cyclopropylmethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 10::US10202369, Example 10::US10472354, Example 10	P2X purinoceptor 2/3	Homo sapiens		 185							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319843	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319843&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397702	384223123							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842461	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1	GTQPEQGDLVSFJO-CXAGYDPISA-N	319844	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 11::US10202369, Example 11::US10472354, Example 291	P2X purinoceptor 2/3	Homo sapiens		 163							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319844	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319844&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397587	384223124							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842463	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18-/m1/s1	GGLGXVJJVCGSBA-CRAIPNDOSA-N	319849	N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 16::US10202369, Example 16::US10472354, Example 16	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319849	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319849&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397267	384223129							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842465	CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1	YETTUNLUNMEXML-LRHAYUFXSA-N	319846	N-[1-(3-chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 13::US10202369, Example 13::US10472354, Example 13	P2X purinoceptor 2/3	Homo sapiens		 1102							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319846	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319846&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397669	384223126							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842467	CC(NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m1/s1	DLODQDUFIVUCLQ-LRHAYUFXSA-N	319847	N-[1-(5-chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 14::US10202369, Example 14::US10472354, Example 14	P2X purinoceptor 2/3	Homo sapiens		 88.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319847	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319847&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397583	384223127							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842469	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1	InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18-/m1/s1	DURBVTDNVKUTOV-RDTXWAMCSA-N	319848	N-[(1R)-1-(5-chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 15::US10202369, Example 15::US10472354, Example 15	P2X purinoceptor 2/3	Homo sapiens		 147							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319848	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319848&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397630	384223128							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842471	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18-/m1/s1	GGLGXVJJVCGSBA-CRAIPNDOSA-N	319849	N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 16::US10202369, Example 16::US10472354, Example 16	P2X purinoceptor 2/3	Homo sapiens		 1707							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319849	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319849&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397267	384223129							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842473	Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m1/s1	VKRRMZCTKMLCQJ-GOSISDBHSA-N	319850	N-[(6-methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 17::US10202369, Example 17::US10472354, Example 17	P2X purinoceptor 2/3	Homo sapiens		 1005							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319850	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319850&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397146	384223130							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842475	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18-/m1/s1	JJXMVDHMQZPOJY-CRAIPNDOSA-N	319851	N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 18::US10202369, Example 18::US10472354, Example 18	P2X purinoceptor 2/3	Homo sapiens		 427							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319851	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319851&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397758	384223131							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842477	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-10-26-21(33-12)15-7-14(8-17(9-15)32-16-5-6-31-11-16)20(30)27-13(2)18-3-4-19(29-28-18)22(23,24)25/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,27,30)/t13-,16-/m1/s1	DNHMMXLROIMBSA-CZUORRHYSA-N	319852	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 19::US10202369, Example 19::US10472354, Example 19	P2X purinoceptor 2/3	Homo sapiens		 749							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319852	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319852&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397747	384223132							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842479	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1	InChI=1S/C20H22N4O3S2/c1-11-9-21-20(28-11)15-6-14(7-17(8-15)27-16-4-5-26-10-16)18(25)22-12(2)19-24-23-13(3)29-19/h6-9,12,16H,4-5,10H2,1-3H3,(H,22,25)/t12-,16-/m1/s1	WVNVOAPVSAUSTP-MLGOLLRUSA-N	319853	N-[(1R)-1-(5-methyl-1,3,4-thiadiazol-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 20::US10202369, Example 20::US10472354, Example 20	P2X purinoceptor 2/3	Homo sapiens		 486							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319853	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319853&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397835	384223133							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842481	Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F	InChI=1S/C21H19F3N4O3S/c1-12-9-26-20(32-12)14-6-13(7-17(8-14)31-16-4-5-30-11-16)19(29)25-10-15-2-3-18(28-27-15)21(22,23)24/h2-3,6-9,16H,4-5,10-11H2,1H3,(H,25,29)/t16-/m1/s1	YZCYRJHHBOIVER-MRXNPFEDSA-N	319854	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{[6-(trifluoromethyl)pyridazin-3-yl]methyl}benzamide::US10174016, Example 21::US10202369, Example 21::US10472354, Example 21	P2X purinoceptor 2/3	Homo sapiens		 445							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319854	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319854&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397575	384223134							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842483	CC[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-3-19(16-10-28-22(29-11-16)23(24,25)26)30-20(31)14-6-15(21-27-9-13(2)34-21)8-18(7-14)33-17-4-5-32-12-17/h6-11,17,19H,3-5,12H2,1-2H3,(H,30,31)/t17-,19-/m1/s1	VUXDKUAYZMWTBM-IEBWSBKVSA-N	319855	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]propyl}benzamide::US10174016, Example 22::US10202369, Example 22::US10472354, Example 22	P2X purinoceptor 2/3	Homo sapiens		 987							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319855	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319855&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397246	384223135							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842485	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)C1=[S]C=C(C)N1)c1cnc(C)nc1	InChI=1S/C22H25N4O3S/c1-13-12-30-22(25-13)17-6-16(7-20(8-17)29-19-4-5-28-11-19)21(27)26-14(2)18-9-23-15(3)24-10-18/h6-10,12,14,19,25H,4-5,11H2,1-3H3,(H,26,27)/t14-,19-/m1/s1	XUSIIGAFSFFFBZ-AUUYWEPGSA-N	419937	US10472354, Example 23	P2X purinoceptor 2/3	Homo sapiens		 1106							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419937&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search											2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842487	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20+/m1/s1	KGDPEGCMVCXNPY-UZLBHIALSA-N	319863	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran- 3-yloxy] benzamide::US10174016, Example 30::US10202369, Example 30::US10472354, Example 30	P2X purinoceptor 2/3	Homo sapiens		 332							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319863&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397828	384223143							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842489	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-13-4-5-20(26-25-13)15(3)24-21(27)16-8-17(22-23-11-14(2)30-22)10-19(9-16)29-18-6-7-28-12-18/h4-5,8-11,15,18H,6-7,12H2,1-3H3,(H,24,27)/t15-,18+/m1/s1	JJXMVDHMQZPOJY-QAPCUYQASA-N	319858	N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 25::US10202369, Example 25::US10472354, Example 25	P2X purinoceptor 2/3	Homo sapiens		 975							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319858	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319858&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397569	384223138							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842491	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17+/m1/s1	GTQPEQGDLVSFJO-DYVFJYSZSA-N	319859	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 26::US10202369, Example 26::US10472354, Example 26	P2X purinoceptor 2/3	Homo sapiens		 297							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319859	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319859&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397418	384223139							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842493	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1	InChI=1S/C22H22ClN3O3S/c1-13-10-25-22(30-13)16-7-15(8-19(9-16)29-18-5-6-28-12-18)21(27)26-14(2)20-4-3-17(23)11-24-20/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,26,27)/t14-,18+/m1/s1	DURBVTDNVKUTOV-KDOFPFPSSA-N	319860	N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 27::US10202369, Example 27::US10472354, Example 27	P2X purinoceptor 2/3	Homo sapiens		 280							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319860	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319860&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397158	384223140							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842495	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)cn1	InChI=1S/C23H25N3O3S/c1-14-4-5-21(24-11-14)16(3)26-22(27)17-8-18(23-25-12-15(2)30-23)10-20(9-17)29-19-6-7-28-13-19/h4-5,8-12,16,19H,6-7,13H2,1-3H3,(H,26,27)/t16-,19+/m1/s1	CFTQNAYGOFQJGD-APWZRJJASA-N	319861	N-[(1R)-1-(5-Methylpyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 28::US10202369, Example 28::US10472354, Example 28	P2X purinoceptor 2/3	Homo sapiens		 121							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319861	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319861&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397224	384223141							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842497	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-13-9-24-20(11-23-13)15(3)26-21(27)16-6-17(22-25-10-14(2)30-22)8-19(7-16)29-18-4-5-28-12-18/h6-11,15,18H,4-5,12H2,1-3H3,(H,26,27)/t15-,18+/m1/s1	GGLGXVJJVCGSBA-QAPCUYQASA-N	319862	N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 29::US10472354, Example 29	P2X purinoceptor 2/3	Homo sapiens		 580							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319862	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319862&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397726	384223142							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842499	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C23H25N3O3S/c1-14-4-5-17(12-24-14)16(3)26-22(27)18-8-19(23-25-11-15(2)30-23)10-21(9-18)29-20-6-7-28-13-20/h4-5,8-12,16,20H,6-7,13H2,1-3H3,(H,26,27)/t16-,20+/m1/s1	KGDPEGCMVCXNPY-UZLBHIALSA-N	319863	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran- 3-yloxy] benzamide::US10174016, Example 30::US10202369, Example 30::US10472354, Example 30	P2X purinoceptor 2/3	Homo sapiens		 485							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319863	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319863&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397828	384223143							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842501	Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C20H18N4O2S/c1-4-7-26-18-9-15(8-16(10-18)20-22-11-14(3)27-20)19(25)21-12-17-6-5-13(2)23-24-17/h1,5-6,8-11H,7,12H2,2-3H3,(H,21,25)	JDOBHPRLWOBCFP-UHFFFAOYSA-N	319864	N-[(6- Methylpyridazin-  3-yl)methyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 31::US10202369, Example 31::US10472354, Example 31	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319864	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319864&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397457	384223144							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842503	Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1ncc(Cl)cc1F	InChI=1S/C20H15ClFN3O2S/c1-3-4-27-16-6-13(5-14(7-16)20-25-9-12(2)28-20)19(26)24-11-18-17(22)8-15(21)10-23-18/h1,5-10H,4,11H2,2H3,(H,24,26)	VKJAMZXKIQCHSG-UHFFFAOYSA-N	322220	N-[(5-Chloro-3- fluoropyridin-2- yl)methyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10183937, Example 32::US10202369, Example 32::US10472354, Example 32	P2X purinoceptor 2/3	Homo sapiens		 1781							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322220	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322220&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397185	384225297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842505	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C22H21N3O2S/c1-5-8-27-20-10-18(9-19(11-20)22-24-12-15(3)28-22)21(26)25-16(4)17-7-6-14(2)23-13-17/h1,6-7,9-13,16H,8H2,2-4H3,(H,25,26)/t16-/m1/s1	ZCHZUISZWKOUTB-MRXNPFEDSA-N	319866	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 33::US10202369, Example 33::US10472354, Example 33	P2X purinoceptor 2/3	Homo sapiens		 912							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319866	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319866&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397790	384223146							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842507	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C21H20N4O2S/c1-5-6-27-18-8-16(7-17(9-18)21-24-11-14(3)28-21)20(26)25-15(4)19-12-22-13(2)10-23-19/h1,7-12,15H,6H2,2-4H3,(H,25,26)/t15-/m1/s1	UJLVWKMINNYJSM-OAHLLOKOSA-N	319867	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (prop-2-yn-1- yloxy) benzamide::US10174016, Example 34::US10202369, Example 34::US10472354, Example 34	P2X purinoceptor 2/3	Homo sapiens		 2124							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319867	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319867&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397514	384223147							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843237	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19-/m1/s1	UCMZCPXWJACEJN-AUUYWEPGSA-N	320232	3-{[(2R)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 399::US10202369, Example 399::US10472354, Example 399	P2X purinoceptor 2/3	Homo sapiens		 1722							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320232	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320232&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397565	384223504							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843239	C[C@@H](NC(=O)c1cc(OC[C@@H]2CNC(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-6-28-21(36-12)15-3-14(4-17(5-15)34-10-18-9-27-19(32)11-35-18)20(33)31-13(2)16-7-29-22(30-8-16)23(24,25)26/h3-8,13,18H,9-11H2,1-2H3,(H,27,32)(H,31,33)/t13-,18+/m1/s1	SQKDWNUUISQXQF-ACJLOTCBSA-N	320233	3-(5-methyl-1,3- thiazol-2-yl)-5- {[(2S)-5- oxomorpholin-2- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 400::US10202369, Example 400::US10472354, Example 400	P2X purinoceptor 2/3	Homo sapiens		 1477							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320233	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320233&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397173	384223505							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843241	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)C(=O)CO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-18(6-16)35-11-19-10-32(3)20(33)12-36-19)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,19H,10-12H2,1-3H3,(H,31,34)/t14-,19+/m1/s1	UCMZCPXWJACEJN-KUHUBIRLSA-N	320234	3-{[(2S)-4-methyl-5- oxomorpholin-2-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 401::US10202369, Example 401::US10472354, Example 401	P2X purinoceptor 2/3	Homo sapiens		 1466							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320234	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320234&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397710	384223506							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843243	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCC(=O)N2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O4S/c1-13-7-28-22(37-13)16-4-15(5-19(6-16)36-11-18-10-35-12-20(33)32(18)3)21(34)31-14(2)17-8-29-23(30-9-17)24(25,26)27/h4-9,14,18H,10-12H2,1-3H3,(H,31,34)/t14-,18+/m1/s1	SDFLFPYVVNTAIN-KDOFPFPSSA-N	320235	3-{[(3S)-4-methyl-5- oxomorpholin-3-yl] methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 402::US10472354, Example 402	P2X purinoceptor 2/3	Homo sapiens		 1251							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320235	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320235&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397212	384223507							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843245	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCC(=O)N2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H22F3N5O4S/c1-12-6-27-21(36-12)15-3-14(4-18(5-15)35-10-17-9-34-11-19(32)31-17)20(33)30-13(2)16-7-28-22(29-8-16)23(24,25)26/h3-8,13,17H,9-11H2,1-2H3,(H,30,33)(H,31,32)/t13-,17+/m1/s1	QBCIMXIDQXCQLC-DYVFJYSZSA-N	320236	3-(5-methyl-1,3- thiazol-2-yl)-5- {[(3S)-5- oxomorpholin-3- yl]methoxy}-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 403::US10472354, Example 403	P2X purinoceptor 2/3	Homo sapiens		 2108							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320236	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320236&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397456	384223508							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843247	C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C29H32F3N5O5S/c1-16-10-33-24(43-16)19-6-18(23(38)36-17(2)20-11-34-25(35-12-20)29(30,31)32)7-22(8-19)40-15-28-9-21(13-41-28)37(14-28)26(39)42-27(3,4)5/h6-8,10-12,17,21H,9,13-15H2,1-5H3,(H,36,38)/t17-,21?,28?/m1/s1	FPSSQFUABOQNNZ-RWNQLPSJSA-N	320237	US10174016, Example 404::US10202369, Example 404::US10472354, Example 404::tert-butyl 1-{[3-(5- methyl-1,3-thiazol- 2-yl)-5-({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]methyl}-2- oxa-5- azabicyclo[2.2.1] heptane-5- carboxylate, as a mixture of 2 diastereoisomers	P2X purinoceptor 2/3	Homo sapiens		 533							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320237	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320237&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397508	384223509							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843249	CC(C)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2	InChI=1S/C27H30F3N5O3S/c1-15(2)35-13-26(8-21(35)12-38-26)14-37-22-6-18(5-19(7-22)24-31-9-16(3)39-24)23(36)34-17(4)20-10-32-25(33-11-20)27(28,29)30/h5-7,9-11,15,17,21H,8,12-14H2,1-4H3,(H,34,36)/t17-,21?,26?/m1/s1	YPUYZHJKGABFEF-XJNIYMOYSA-N	320238	3-[(5-isopropyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 405::US10202369, Example 405::US10472354, Example 405	P2X purinoceptor 2/3	Homo sapiens		 1558							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320238	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320238&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397496	384223510							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843251	C[C@@H](NC(=O)c1cc(OCC23CC(CO2)N(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O3S/c1-14-8-29-22(37-14)17-4-16(5-20(6-17)35-13-24-7-19(11-36-24)33(3)12-24)21(34)32-15(2)18-9-30-23(31-10-18)25(26,27)28/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,32,34)/t15-,19?,24?/m1/s1	QZIIXNSQPLEQAW-QOFOLWBBSA-N	320239	3-[(5-methyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 406::US10202369, Example 406::US10472354, Example 406	P2X purinoceptor 2/3	Homo sapiens		 2026							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320239	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320239&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397318	384223511							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843253	C[C@@H](NC(=O)c1cc(OCC23CNC(CO2)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O3S/c1-13-7-28-21(36-13)16-3-15(4-19(5-16)34-12-23-6-18(10-35-23)31-11-23)20(33)32-14(2)17-8-29-22(30-9-17)24(25,26)27/h3-5,7-9,14,18,31H,6,10-12H2,1-2H3,(H,32,33)/t14-,18?,23?/m1/s1	NAZJZFLNXXGFCR-IHDUPTFDSA-N	320240	3-(5-Methyl-1,3-thiazol-2-yl)-5-[2-oxa-5-azabicyclo[2.2.1]hept-1-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of 2 Diastereoisomers::US10174016, Example 407::US10202369, Example 407::US10472354, Example 407	P2X purinoceptor 2/3	Homo sapiens		 1681							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320240	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320240&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397648	384223512							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843255	CCCN1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2	InChI=1S/C27H30F3N5O3S/c1-4-5-35-14-26(9-21(35)13-38-26)15-37-22-7-18(6-19(8-22)24-31-10-16(2)39-24)23(36)34-17(3)20-11-32-25(33-12-20)27(28,29)30/h6-8,10-12,17,21H,4-5,9,13-15H2,1-3H3,(H,34,36)/t17-,21?,26?/m1/s1	AAPJJGZIWGLKBD-XJNIYMOYSA-N	320241	3-(5-methyl-1,3- thiazol-2-yl)-5-[(5- propyl-2- oxa-5-azabicyclo [2.2.1]hept-1-yl) methoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 408::US10202369, Example 408::US10472354, Example 408	P2X purinoceptor 2/3	Homo sapiens		 1710							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320241	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320241&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397789	384223513							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843257	COC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2	InChI=1S/C26H26F3N5O5S/c1-14-8-30-22(40-14)17-4-16(21(35)33-15(2)18-9-31-23(32-10-18)26(27,28)29)5-20(6-17)38-13-25-7-19(11-39-25)34(12-25)24(36)37-3/h4-6,8-10,15,19H,7,11-13H2,1-3H3,(H,33,35)/t15-,19?,25?/m1/s1	ACUSXDHHFJWBEG-QYRGRQSGSA-N	320242	Methyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a mixture of 2 diastereoisomers::US10174016, Example 409::US10202369, Example 409::US10472354, Example 409	P2X purinoceptor 2/3	Homo sapiens		 976							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320242	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320242&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397200	384223514							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843259	CCOC(=O)N1CC2(COc3cc(cc(c3)-c3ncc(C)s3)C(=O)N[C@H](C)c3cnc(nc3)C(F)(F)F)CC1CO2	InChI=1S/C27H28F3N5O5S/c1-4-38-25(37)35-13-26(8-20(35)12-40-26)14-39-21-6-17(5-18(7-21)23-31-9-15(2)41-23)22(36)34-16(3)19-10-32-24(33-11-19)27(28,29)30/h5-7,9-11,16,20H,4,8,12-14H2,1-3H3,(H,34,36)/t16-,20?,26?/m1/s1	MVNNYWBQRAUUBD-ORALUJHKSA-N	320243	Ethyl 1-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate, as a Mixture of 2 Diastereoisomers::US10174016, Example 410::US10202369, Example 410::US10472354, Example 410	P2X purinoceptor 2/3	Homo sapiens		 906							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320243	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320243&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397180	384223515							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843261	CCN1CCO[C@H](COc2cc(cc(c2)-c2ncc(C)s2)C(=O)N[C@H](C)c2cnc(nc2)C(F)(F)F)C1	InChI=1S/C25H28F3N5O3S/c1-4-33-5-6-35-21(13-33)14-36-20-8-17(7-18(9-20)23-29-10-15(2)37-23)22(34)32-16(3)19-11-30-24(31-12-19)25(26,27)28/h7-12,16,21H,4-6,13-14H2,1-3H3,(H,32,34)/t16-,21+/m1/s1	IJXNJADLTIUKEL-IERDGZPVSA-N	320244	3-{[(2S)-4-ethylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 411::US10202369, Example 411::US10472354, Example 411	P2X purinoceptor 2/3	Homo sapiens		 697							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320244	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320244&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397533	384223516							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843263	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22-/m1/s1	OEKUZTDVCYAZBS-VGOFRKELSA-N	320179	Tert-butyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 346::US10202369, Example 346::US10472354, Example 346	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320179&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338449	384223452							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843265	C[C@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m0/s1	HRVUBTPQOQIHTK-IFXJQAMLSA-N	320246	3-(5-methyl- 1,3-thiazol-2- yl)-5-[(2R)- morpholin-2- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 413::US10202369, Example 413::US10472354, Example 413	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320246	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320246&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397518	384223518							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843267	CCc1cnc(s1)-c1cc(OC[C@@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18+/m1/s1	PAVCMPZQEBSSQV-KDOFPFPSSA-N	320247	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 414::US10202369, Example 414::US10472354, Example 414	P2X purinoceptor 2/3	Homo sapiens		 2272							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320247	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320247&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397150	384223519							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843269	CCc1cnc(s1)-c1cc(OC[C@H]2CNCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-3-19-12-29-23(36-19)16-8-15(9-17(10-16)35-13-18-11-28-6-7-34-18)22(33)30-14(2)20-4-5-21(32-31-20)24(25,26)27/h4-5,8-10,12,14,18,28H,3,6-7,11,13H2,1-2H3,(H,30,33)/t14-,18-/m1/s1	PAVCMPZQEBSSQV-RDTXWAMCSA-N	320248	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2R)- morpholin-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 415::US10202369, Example 415::US10472354, Example 415	P2X purinoceptor 2/3	Homo sapiens		 2177							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320248	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320248&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397550	384223520							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843271	C[C@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19+/m0/s1	IJFKDPNABTXGCF-HNAYVOBHSA-N	420355	3-{[(2R)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10472354, Example 416	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420355	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420355&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search											2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843273	C[C@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-11-28-23(36-14)17-8-16(9-18(10-17)35-13-19-12-32(3)6-7-34-19)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,15,19H,6-7,12-13H2,1-3H3,(H,29,33)/t15-,19-/m0/s1	IJFKDPNABTXGCF-KXBFYZLASA-N	420356	3-{[(2S)-4- methylmorpholin- 2-yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10472354, Example 417	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420356	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420356&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search											2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843275	CCc1cnc(s1)-c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19+/m1/s1	SIFMRPZFMXLARV-BEFAXECRSA-N	322607	3-(5-Ethyl-1,3- thiazol-2-yl)-5- {[(2S)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 418::US10202369, Example 418::US10472354, Example 418	P2X purinoceptor 2/3	Homo sapiens		 1556							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322607	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322607&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397330	384225667							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843277	CCc1cnc(s1)-c1cc(OC[C@H]2CN(C)CCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H28F3N5O3S/c1-4-20-12-29-24(37-20)17-9-16(10-18(11-17)36-14-19-13-33(3)7-8-35-19)23(34)30-15(2)21-5-6-22(32-31-21)25(26,27)28/h5-6,9-12,15,19H,4,7-8,13-14H2,1-3H3,(H,30,34)/t15-,19-/m1/s1	SIFMRPZFMXLARV-DNVCBOLYSA-N	322608	3-(5-ethyl-1,3- thiazol-2-yl)-5- {[(2R)-4- methyl- morpholin-2- yl]methoxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10183937, Example 419::US10202369, Example 419::US10472354, Example 419	P2X purinoceptor 2/3	Homo sapiens		 1136							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322608	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322608&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397262	384225668							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842509	Cc1cnc(s1)-c1cc(OCC#C)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C20H18N4O2S/c1-4-5-26-18-7-15(6-16(8-18)20-24-10-14(3)27-20)19(25)23-12-17-11-21-13(2)9-22-17/h1,6-11H,5,12H2,2-3H3,(H,23,25)	HKQDCIZFKBUDQD-UHFFFAOYSA-N	319868	N-[(5- Methylpyrazin- 2-yl)methyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy)benzamide::US10174016, Example 35::US10202369, Example 35::US10472354, Example 35	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319868	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319868&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397704	384223148							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842511	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m1/s1	BTRSFHCVZJPJKT-CYBMUJFWSA-N	319869	3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 36::US10202369, Example 36::US10472354, Example 36	P2X purinoceptor 2/3	Homo sapiens		 306							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319869&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397309	384223149							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842513	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C21H20N4O2S/c1-5-8-27-18-10-16(9-17(11-18)21-22-12-14(3)28-21)20(26)23-15(4)19-7-6-13(2)24-25-19/h1,6-7,9-12,15H,8H2,2-4H3,(H,23,26)/t15-/m1/s1	IZIUFNSLLIEWJE-OAHLLOKOSA-N	319870	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 37::US10202369, Example 37::US10472354, Example 37	P2X purinoceptor 2/3	Homo sapiens		 1176							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319870&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397261	384223150							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842515	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C21H17F3N4O2S/c1-4-7-30-16-9-14(8-15(10-16)20-25-11-12(2)31-20)19(29)26-13(3)17-5-6-18(28-27-17)21(22,23)24/h1,5-6,8-11,13H,7H2,2-3H3,(H,26,29)/t13-/m1/s1	PNZFOFJAUOCDQW-CYBMUJFWSA-N	319871	3-(5-Methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1-yloxy)-N- [(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 38::US10202369, Example 38::US10472354, Example 38	P2X purinoceptor 2/3	Homo sapiens		 1145							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319871&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397333	384223151							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842517	C[C@@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C21H20N4O2S/c1-5-6-27-19-8-16(7-17(9-19)21-24-10-13(2)28-21)20(26)25-14(3)18-11-22-15(4)23-12-18/h1,7-12,14H,6H2,2-4H3,(H,25,26)/t14-/m1/s1	OVENJFXCZONLOP-CQSZACIVSA-N	319872	N-[(1R)-1-(2- Methylpyrimidin- 5-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(prop-2- yn-1- yloxy) benzamide::US10174016, Example 39::US10202369, Example 39::US10472354, Example 39	P2X purinoceptor 2/3	Homo sapiens		 1646							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319872	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319872&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397588	384223152							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842519	CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H19F3N4O2S/c1-4-5-6-31-18-8-15(7-16(9-18)20-26-10-13(2)32-20)19(30)29-14(3)17-11-27-21(28-12-17)22(23,24)25/h7-12,14H,6H2,1-3H3,(H,29,30)/t14-/m1/s1	XSZOYFWYESZINQ-CQSZACIVSA-N	319873	3-(But-2-yn-1- yloxy)-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 40::US10202369, Example 40::US10472354, Example 40	P2X purinoceptor 2/3	Homo sapiens		 383							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319873	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319873&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397357	384223153							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842521	CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1nnc(C)s1	InChI=1S/C20H20N4O2S2/c1-5-6-7-26-17-9-15(8-16(10-17)20-21-11-12(2)27-20)18(25)22-13(3)19-24-23-14(4)28-19/h8-11,13H,7H2,1-4H3,(H,22,25)/t13-/m1/s1	ORWZAOZYNYEGDS-CYBMUJFWSA-N	319874	3-(But-2-yn-1- yloxy)-N-[(1R)- 1-(5-methyl- 1,3,4- thiadiazol-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 41::US10202369, Example 41::US10472354, Example 41	P2X purinoceptor 2/3	Homo sapiens		 1592							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319874	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319874&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397286	384223154							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842523	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C21H22N4O3S/c1-12-7-23-19(9-22-12)14(3)25-20(26)15-4-16(21-24-8-13(2)29-21)6-17(5-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,25,26)/t14-/m1/s1	AWWAAAATSKEOQH-CQSZACIVSA-N	319875	N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 42::US10202369, Example 42::US10472354, Example 42	P2X purinoceptor 2/3	Homo sapiens		 1565							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319875	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319875&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397394	384223155							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842525	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C21H22N4O3S/c1-12-7-24-21(29-12)16-4-15(5-18(6-16)28-19-10-27-11-19)20(26)25-13(2)17-8-22-14(3)23-9-17/h4-9,13,19H,10-11H2,1-3H3,(H,25,26)/t13-/m1/s1	QZYMXYIOESSIBG-CYBMUJFWSA-N	319876	N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 43::US10202369, Example 43::US10472354, Example 43	P2X purinoceptor 2/3	Homo sapiens		 2688							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319876	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319876&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397750	384223156							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842527	CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(23)6-15(22)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27)	DXVSMJSLGFWBSV-UHFFFAOYSA-N	319877	N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 44::US10202369, Example 44::US10472354, Example 44	P2X purinoceptor 2/3	Homo sapiens		 370							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319877	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319877&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397182	384223157							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842529	Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C20H20N4O3S/c1-12-3-4-16(24-23-12)9-21-19(25)14-5-15(20-22-8-13(2)28-20)7-17(6-14)27-18-10-26-11-18/h3-8,18H,9-11H2,1-2H3,(H,21,25)	AFIPEIBYSBBLBJ-UHFFFAOYSA-N	319878	N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 45::US10202369, Example 45::US10472354, Example 45	P2X purinoceptor 2/3	Homo sapiens		 1510							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319878&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397740	384223158							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842531	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(Cl)cn1	InChI=1S/C21H20ClN3O3S/c1-12-8-24-21(29-12)15-5-14(6-17(7-15)28-18-10-27-11-18)20(26)25-13(2)19-4-3-16(22)9-23-19/h3-9,13,18H,10-11H2,1-2H3,(H,25,26)/t13-/m1/s1	FFCGGIUVAQWIMW-CYBMUJFWSA-N	319879	N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 46::US10202369, Example 46::US10472354, Example 46	P2X purinoceptor 2/3	Homo sapiens		 389							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319879&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397660	384223159							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842533	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C21H22N4O3S/c1-12-4-5-19(25-24-12)14(3)23-20(26)15-6-16(21-22-9-13(2)29-21)8-17(7-15)28-18-10-27-11-18/h4-9,14,18H,10-11H2,1-3H3,(H,23,26)/t14-/m1/s1	HFDOVXXFUCEVBK-CQSZACIVSA-N	319880	N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 47::US10202369, Example 47::US10472354, Example 47	P2X purinoceptor 2/3	Homo sapiens		 621							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319880&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397352	384223160							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842535	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H19F3N4O3S/c1-11-6-25-19(32-11)14-3-13(4-16(5-14)31-17-9-30-10-17)18(29)28-12(2)15-7-26-20(27-8-15)21(22,23)24/h3-8,12,17H,9-10H2,1-2H3,(H,28,29)/t12-/m1/s1	HXNSKECKPLVRIH-GFCCVEGCSA-N	319881	3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 48::US10202369, Example 48::US10472354, Example 48	P2X purinoceptor 2/3	Homo sapiens		 451							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319881&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397291	384223161							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842537	CC(NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C21H19ClFN3O3S/c1-11-7-25-21(30-11)14-3-13(4-16(5-14)29-17-9-28-10-17)20(27)26-12(2)19-18(22)6-15(23)8-24-19/h3-8,12,17H,9-10H2,1-2H3,(H,26,27)	FNMVOFQACWEVTO-UHFFFAOYSA-N	319882	N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)benzamide::US10174016, Example 49::US10202369, Example 49::US10472354, Example 49	P2X purinoceptor 2/3	Homo sapiens		 1525							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319882&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397320	384223162							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842539	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)C1=[S]C=C(C)N1)c1nnc(C)s1	InChI=1S/C19H21N4O3S2/c1-10-9-27-19(20-10)14-4-13(5-15(6-14)26-16-7-25-8-16)17(24)21-11(2)18-23-22-12(3)28-18/h4-6,9,11,16,20H,7-8H2,1-3H3,(H,21,24)/t11-/m1/s1	VNOLWUXOQFRHOP-LLVKDONJSA-N	419970	US10472354, Example 50	P2X purinoceptor 2/3	Homo sapiens		 982							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419970&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search											2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842541	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)C1=[S]C(C)=CN1)c1ccc(C)nc1	InChI=1S/C22H24N3O3S/c1-13-4-5-16(10-23-13)15(3)25-21(26)17-6-18(22-24-9-14(2)29-22)8-19(7-17)28-20-11-27-12-20/h4-10,15,20,24H,11-12H2,1-3H3,(H,25,26)/t15-/m1/s1	GAVXGHHYABXHOQ-OAHLLOKOSA-N	419971	US10472354, Example 51	P2X purinoceptor 2/3	Homo sapiens		 1389							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419971&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search											2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842543	Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1ccc(nn1)C(F)(F)F	InChI=1S/C20H17F3N4O3S/c1-11-7-25-19(31-11)13-4-12(5-15(6-13)30-16-9-29-10-16)18(28)24-8-14-2-3-17(27-26-14)20(21,22)23/h2-7,16H,8-10H2,1H3,(H,24,28)	KTKYNBLLOZOZPY-UHFFFAOYSA-N	319885	3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N-{[6- (trifluoromethyl) pyridazin-3- yl]methyl} benzamide::US10174016, Example 52::US10202369, Example 52::US10472354, Example 52	P2X purinoceptor 2/3	Homo sapiens		 564							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319885&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397650	384223165							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842545	CC[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-3-18(15-8-27-21(28-9-15)22(23,24)25)29-19(30)13-4-14(20-26-7-12(2)33-20)6-16(5-13)32-17-10-31-11-17/h4-9,17-18H,3,10-11H2,1-2H3,(H,29,30)/t18-/m1/s1	PHCWFMJDVHAVQT-GOSISDBHSA-N	319886	3-(5-Methyl- 1,3-thiazol-2- yl)-5-(oxetan- 3-yloxy)-N- [(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]propyl] benzamide::US10174016, Example 53::US10202369, Example 53::US10472354, Example 53	P2X purinoceptor 2/3	Homo sapiens		 2740							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319886&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397526	384223166							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842547	Cc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m0/s1	IFCRFQDQDLUKDL-IBGZPJMESA-N	319887	N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 54::US10202369, Example 54::US10472354, Example 54	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319887&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397485	384223167							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842549	CC1=CNC(=[S]1)c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1ncc(Cl)cc1F	InChI=1S/C22H22ClFN3O3S/c1-13-9-27-22(31-13)15-5-14(6-18(7-15)30-12-17-3-2-4-29-17)21(28)26-11-20-19(24)8-16(23)10-25-20/h5-10,17,27H,2-4,11-12H2,1H3,(H,26,28)/t17-/m0/s1	ALVAUYIPIZELRY-KRWDZBQOSA-N	419975	US10472354, Example 55	P2X purinoceptor 2/3	Homo sapiens		 325							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419975&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search											2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842551	CC1=CNC(=[S]1)c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C22H25N4O3S/c1-14-9-24-18(11-23-14)12-25-21(27)16-6-17(22-26-10-15(2)30-22)8-20(7-16)29-13-19-4-3-5-28-19/h6-11,19,26H,3-5,12-13H2,1-2H3,(H,25,27)/t19-/m0/s1	UAHUKPQUPXOADJ-IBGZPJMESA-N	419976	US10472354, Example 56	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419976&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search											2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842553	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19+/m1/s1	MANPQCKCYFRFOG-APWZRJJASA-N	319890	N-[(1R)-1-(5-Methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 57::US10202369, Example 57::US10472354, Example 57	P2X purinoceptor 2/3	Homo sapiens		 2840							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319890	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319890&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397390	384223170							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842555	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18+/m1/s1	MXZPUDRHAAYJOR-KDOFPFPSSA-N	319891	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 58::US10202369, Example 58::US10472354, Example 58	P2X purinoceptor 2/3	Homo sapiens		 461							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319891&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397134	384223171							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842557	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19+/m1/s1	JHPJVAOLQKHAFN-APWZRJJASA-N	319892	N-[(1R)-1-(6-Methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 59::US10202369, Example 59::US10472354, Example 59	P2X purinoceptor 2/3	Homo sapiens		 507							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319892	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319892&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397721	384223172							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842559	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-11-27-22(34-13)16-8-15(9-18(10-16)33-12-17-4-3-7-32-17)21(31)28-14(2)19-5-6-20(30-29-19)23(24,25)26/h5-6,8-11,14,17H,3-4,7,12H2,1-2H3,(H,28,31)/t14-,17+/m1/s1	KNJYTDFISMIFTK-PBHICJAKSA-N	319893	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 60::US10202369, Example 60::US10472354, Example 60	P2X purinoceptor 2/3	Homo sapiens		 578							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319893&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397124	384223173							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842561	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-6-7-21(27-26-14)16(3)25-22(28)17-9-18(23-24-12-15(2)31-23)11-20(10-17)30-13-19-5-4-8-29-19/h6-7,9-12,16,19H,4-5,8,13H2,1-3H3,(H,25,28)/t16-,19-/m1/s1	JHPJVAOLQKHAFN-VQIMIIECSA-N	319894	N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 61::US10202369, Example 61::US10472354, Example 61	P2X purinoceptor 2/3	Homo sapiens		 428							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319894&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397475	384223174							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842563	Cc1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-5-6-18(26-25-14)12-23-21(27)16-8-17(22-24-11-15(2)30-22)10-20(9-16)29-13-19-4-3-7-28-19/h5-6,8-11,19H,3-4,7,12-13H2,1-2H3,(H,23,27)/t19-/m1/s1	IFCRFQDQDLUKDL-LJQANCHMSA-N	319895	N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 62::US10202369, Example 62::US10472354, Example 62	P2X purinoceptor 2/3	Homo sapiens		 1436							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319895	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319895&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397725	384223175							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842565	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-12-18-4-3-5-32-18)20(31)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,3-5,12H2,1-2H3,(H,30,31)/t14-,18-/m1/s1	MXZPUDRHAAYJOR-RDTXWAMCSA-N	319896	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 63::US10202369, Example 63::US10472354, Example 63	P2X purinoceptor 2/3	Homo sapiens		 118							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319896&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397292	384223176							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842567	C[C@@H](NC(=O)c1cc(OC[C@H]2CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-10-25-21(12-24-14)16(3)27-22(28)17-7-18(23-26-11-15(2)31-23)9-20(8-17)30-13-19-5-4-6-29-19/h7-12,16,19H,4-6,13H2,1-3H3,(H,27,28)/t16-,19-/m1/s1	MANPQCKCYFRFOG-VQIMIIECSA-N	319897	N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(2R)-tetrahydrofuran-2-ylmethoxy]benzamide::US10174016, Example 64::US10202369, Example 64::US10472354, Example 64	P2X purinoceptor 2/3	Homo sapiens		 984							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319897&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397244	384223177							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842569	CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1	NHGFOVVSFOISFI-LOACHALJSA-N	319898	N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyL- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 65::US10202369, Example 65::US10472354, Example 65	P2X purinoceptor 2/3	Homo sapiens		 54.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319898&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397187	384223178							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842571	Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m0/s1	SKNHRCMFBDROGE-INIZCTEOSA-N	319899	N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 66::US10202369, Example 66::US10472354, Example 66	P2X purinoceptor 2/3	Homo sapiens		 6295							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319899&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397153	384223179							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842573	Cc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m0/s1	MFTNZVDLSIJVDH-INIZCTEOSA-N	319900	N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 67::US10202369, Example 67::US10472354, Example 67	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319900	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319900&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397127	384223180							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842575	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17+/m1/s1	VCKXOWQZUNTNDF-SJORKVTESA-N	319901	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 68::US10202369, Example 68::US10472354, Example 68	P2X purinoceptor 2/3	Homo sapiens		 1617							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319901&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397617	384223181							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842577	CC(NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(24)8-18(25)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m0/s1	UNHVUPCUCRZLRC-LOACHALJSA-N	319902	N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 69::US10202369, Example 69::US10472354, Example 69	P2X purinoceptor 2/3	Homo sapiens		 937							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319902&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338444	384223182							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842579	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15+/m1/s1	CHPCVIFXIKJNGF-CABCVRRESA-N	319903	3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 70::US10202369, Example 70::US10472354, Example 70	P2X purinoceptor 2/3	Homo sapiens		 78.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319903&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397748	384223183							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842581	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17+/m1/s1	DJBMUKYGNBBQBO-SJORKVTESA-N	319904	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 71::US10202369, Example 71::US10472354, Example 71	P2X purinoceptor 2/3	Homo sapiens		 315							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319904&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397305	384223184							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842583	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15+/m1/s1	BICIIZABCQYPPY-CABCVRRESA-N	319905	3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3S)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 72::US10202369, Example 72::US10472354, Example 72	P2X purinoceptor 2/3	Homo sapiens		 330							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319905&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397781	384223185							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842585	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-8-27-21(34-13)17-5-16(6-19(7-17)33-12-15-3-4-32-11-15)20(31)30-14(2)18-9-28-22(29-10-18)23(24,25)26/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,15-/m1/s1	CHPCVIFXIKJNGF-HUUCEWRRSA-N	319906	3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 73::US10202369, Example 73::US10472354, Example 73	P2X purinoceptor 2/3	Homo sapiens		 101							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319906&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397238	384223186							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842587	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-9-25-21(11-24-14)16(3)27-22(28)18-6-19(23-26-10-15(2)31-23)8-20(7-18)30-13-17-4-5-29-12-17/h6-11,16-17H,4-5,12-13H2,1-3H3,(H,27,28)/t16-,17-/m1/s1	VCKXOWQZUNTNDF-IAGOWNOFSA-N	319907	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 74::US10202369, Example 74::US10472354, Example 74	P2X purinoceptor 2/3	Homo sapiens		 1107							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319907&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397532	384223187							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842589	Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-3-4-19(26-25-14)11-23-21(27)17-7-18(22-24-10-15(2)30-22)9-20(8-17)29-13-16-5-6-28-12-16/h3-4,7-10,16H,5-6,11-13H2,1-2H3,(H,23,27)/t16-/m1/s1	SKNHRCMFBDROGE-MRXNPFEDSA-N	319908	N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 75::US10202369, Example 75::US10472354, Example 75	P2X purinoceptor 2/3	Homo sapiens		 6638							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319908&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397221	384223188							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842591	Cc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-14-8-24-19(10-23-14)11-25-21(27)17-5-18(22-26-9-15(2)30-22)7-20(6-17)29-13-16-3-4-28-12-16/h5-10,16H,3-4,11-13H2,1-2H3,(H,25,27)/t16-/m1/s1	MFTNZVDLSIJVDH-MRXNPFEDSA-N	319909	N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 76::US10202369, Example 76::US10472354, Example 76	P2X purinoceptor 2/3	Homo sapiens		 5789							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319909&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397850	384223189							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842593	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)18-8-19(23-24-11-15(2)31-23)10-20(9-18)30-13-17-6-7-29-12-17/h4-5,8-11,16-17H,6-7,12-13H2,1-3H3,(H,25,28)/t16-,17-/m1/s1	DJBMUKYGNBBQBO-IAGOWNOFSA-N	319910	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzomide::US10174016, Example 77::US10202369, Example 77::US10472354, Example 77	P2X purinoceptor 2/3	Homo sapiens		 183							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319910&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397806	384223190							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842595	CC(NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C23H23ClFN3O3S/c1-13-9-27-23(32-13)17-5-16(6-19(7-17)31-12-15-3-4-30-11-15)22(29)28-14(2)21-20(25)8-18(24)10-26-21/h5-10,14-15H,3-4,11-12H2,1-2H3,(H,28,29)/t14?,15-/m1/s1	NHGFOVVSFOISFI-YSSOQSIOSA-N	319911	N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy] benzamide::US10174016, Example 78::US10202369, Example 78::US10472354, Example 78	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319911&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397720	384223191							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842597	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-10-27-22(34-13)17-7-16(8-18(9-17)33-12-15-5-6-32-11-15)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,15-/m1/s1	BICIIZABCQYPPY-HUUCEWRRSA-N	319912	3-(5-Methyl- 1,3-thiazol-2- yl)-5-[(3R)- tetrahydrofuran- 3-ylmethoxy]- N-[(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl] benzamide::US10174016, Example 79::US10202369, Example 79::US10472354, Example 79	P2X purinoceptor 2/3	Homo sapiens		 413							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319912&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397596	384223192							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842599	CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(24)10-17(25)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29)	SBZIYANVWYKJKX-UHFFFAOYSA-N	319913	N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 80::US10202369, Example 80::US10472354, Example 80	P2X purinoceptor 2/3	Homo sapiens		 339							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319913	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319913&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397324	384223193							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842601	CC(NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C23H23ClFN3O3S/c1-13-11-27-23(32-13)16-7-15(8-19(9-16)31-18-3-5-30-6-4-18)22(29)28-14(2)21-20(25)10-17(24)12-26-21/h7-12,14,18H,3-6H2,1-2H3,(H,28,29)	UXQVDYSQMZTJPS-UHFFFAOYSA-N	319914	N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 81::US10202369, Example 81::US10472354, Example 81	P2X purinoceptor 2/3	Homo sapiens		 34.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319914	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319914&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397622	384223194							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842603	Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C22H24N4O3S/c1-14-3-4-18(26-25-14)13-23-21(27)16-9-17(22-24-12-15(2)30-22)11-20(10-16)29-19-5-7-28-8-6-19/h3-4,9-12,19H,5-8,13H2,1-2H3,(H,23,27)	LSYGQIAUTJTZDJ-UHFFFAOYSA-N	319915	N-[(6- Methylpyridazin- 3-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 82::US10202369, Example 82::US10472354, Example 82	P2X purinoceptor 2/3	Homo sapiens		 380							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319915	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319915&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397341	384223195							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842605	Cc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C22H24N4O3S/c1-14-10-24-18(12-23-14)13-25-21(27)16-7-17(22-26-11-15(2)30-22)9-20(8-16)29-19-3-5-28-6-4-19/h7-12,19H,3-6,13H2,1-2H3,(H,25,27)	YXUSESJBYZNMQE-UHFFFAOYSA-N	319916	N-[(5- Methylpyrazin- 2-yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 83::US10202369, Example 83::US10472354, Example 83	P2X purinoceptor 2/3	Homo sapiens		 1164							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319916&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397170	384223196							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842607	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-14-11-25-21(13-24-14)16(3)27-22(28)17-8-18(23-26-12-15(2)31-23)10-20(9-17)30-19-4-6-29-7-5-19/h8-13,16,19H,4-7H2,1-3H3,(H,27,28)/t16-/m1/s1	USCQOVGUOPYDKF-MRXNPFEDSA-N	319917	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 84::US10202369, Example 84::US10472354, Example 84	P2X purinoceptor 2/3	Homo sapiens		 527							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319917	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319917&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397618	384223197							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842609	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1	WGQQHPGXKFPPTQ-CQSZACIVSA-N	319918	3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 85::US10202369, Example 85::US10472354, Example 85	P2X purinoceptor 2/3	Homo sapiens		 36.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319918&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397801	384223198							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842611	COc1ccc(cn1)[C@@H](C)NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1	InChI=1S/C24H27N3O4S/c1-15-13-26-24(32-15)19-10-18(11-21(12-19)31-20-6-8-30-9-7-20)23(28)27-16(2)17-4-5-22(29-3)25-14-17/h4-5,10-14,16,20H,6-9H2,1-3H3,(H,27,28)/t16-/m1/s1	HOSIWEZQKWEZJW-MRXNPFEDSA-N	319919	N-[(1R)-1-(6- Methoxypyridin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 86::US10202369, Example 86::US10472354, Example 86	P2X purinoceptor 2/3	Homo sapiens		 144							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319919&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397310	384223199							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842613	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-14-4-5-21(27-26-14)16(3)25-22(28)17-10-18(23-24-13-15(2)31-23)12-20(11-17)30-19-6-8-29-9-7-19/h4-5,10-13,16,19H,6-9H2,1-3H3,(H,25,28)/t16-/m1/s1	OIHQARAAGWIFBW-MRXNPFEDSA-N	319920	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 87::US10202369, Example 87::US10472354, Example 87	P2X purinoceptor 2/3	Homo sapiens		 119							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319920&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397290	384223200							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842615	COc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(C)s2)nn1	InChI=1S/C22H24N4O4S/c1-14-12-24-22(31-14)16-9-15(10-19(11-16)30-18-5-7-29-8-6-18)21(27)23-13-17-3-4-20(28-2)26-25-17/h3-4,9-12,18H,5-8,13H2,1-2H3,(H,23,27)	FUPOQWQPMIFATK-UHFFFAOYSA-N	319921	N-[(6- Methoxy- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy) benzamide::US10174016, Example 88::US10202369, Example 88::US10472354, Example 88	P2X purinoceptor 2/3	Homo sapiens		 217							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319921	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319921&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397556	384223201							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842617	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-12-27-22(34-13)16-9-15(10-18(11-16)33-17-5-7-32-8-6-17)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,28,31)/t14-/m1/s1	RJKHHNIHJKFMMR-CQSZACIVSA-N	319922	3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin- 3-yl]ethyl} benzamide::US10174016, Example 89::US10202369, Example 89::US10472354, Example 89	P2X purinoceptor 2/3	Homo sapiens		 199							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319922&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397595	384223202							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842619	CC[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20(17-12-29-23(30-13-17)24(25,26)27)31-21(32)15-8-16(22-28-11-14(2)35-22)10-19(9-15)34-18-4-6-33-7-5-18/h8-13,18,20H,3-7H2,1-2H3,(H,31,32)/t20-/m1/s1	ULSBLOPPTNALIT-HXUWFJFHSA-N	319923	3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- yloxy)-N-{(1R)- 1-[2- (trifluorometh- yl)pyrimidin-5- yl]propyl}benz- amide::US10174016, Example 90::US10202369, Example 90::US10472354, Example 90	P2X purinoceptor 2/3	Homo sapiens		 710							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319923	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319923&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397769	384223203							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842621	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C24H27N3O3S/c1-15-4-5-18(14-25-15)17(3)27-23(28)19-10-20(24-26-13-16(2)31-24)12-22(11-19)30-21-6-8-29-9-7-21/h4-5,10-14,17,21H,6-9H2,1-3H3,(H,27,28)/t17-/m1/s1	VKTBTGUHIBZLBJ-QGZVFWFLSA-N	319924	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 91::US10202369, Example 91::US10472354, Example 91	P2X purinoceptor 2/3	Homo sapiens		 133							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319924&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397502	384223204							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842623	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(C)s1	InChI=1S/C21H24N4O3S2/c1-12-11-22-21(29-12)16-8-15(9-18(10-16)28-17-4-6-27-7-5-17)19(26)23-13(2)20-25-24-14(3)30-20/h8-11,13,17H,4-7H2,1-3H3,(H,23,26)/t13-/m1/s1	GHXRECQLMZGPIV-CYBMUJFWSA-N	319925	N-[(1R)-1-(5- Methyl-1,3,4- thiadiazol-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro- 2H-pyran-4- yloxy)benzamide::US10174016, Example 92::US10202369, Example 92::US10472354, Example 92	P2X purinoceptor 2/3	Homo sapiens		 317							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319925&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397542	384223205							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842625	Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-15-3-4-20(27-26-15)13-24-22(28)18-9-19(23-25-12-16(2)31-23)11-21(10-18)30-14-17-5-7-29-8-6-17/h3-4,9-12,17H,5-8,13-14H2,1-2H3,(H,24,28)	QOXIPNMWVVZPOQ-UHFFFAOYSA-N	319926	N-[(6- Methyl- pyridazin-3- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 93::US10202369, Example 93::US10472354, Example 93	P2X purinoceptor 2/3	Homo sapiens		 385							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319926&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397788	384223206							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842627	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-15-11-26-22(13-25-15)17(3)28-23(29)19-8-20(24-27-12-16(2)32-24)10-21(9-19)31-14-18-4-6-30-7-5-18/h8-13,17-18H,4-7,14H2,1-3H3,(H,28,29)/t17-/m1/s1	HCAZTDIYUNBLAC-QGZVFWFLSA-N	319927	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 94::US10202369, Example 94::US10472354, Example 94	P2X purinoceptor 2/3	Homo sapiens		 132							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319927&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397604	384223207							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842629	CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(26)10-19(25)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30)	WLBXKEKEIMKGRV-UHFFFAOYSA-N	319928	N-[1-(5- Chloro-3- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran--4- ylmethoxy) benzamide::US10174016, Example 95::US10202369, Example 95::US10472354, Example 95	P2X purinoceptor 2/3	Homo sapiens		 129							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319928&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397656	384223208							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842631	CC(NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C24H25ClFN3O3S/c1-14-11-28-24(33-14)18-7-17(8-20(9-18)32-13-16-3-5-31-6-4-16)23(30)29-15(2)22-21(25)10-19(26)12-27-22/h7-12,15-16H,3-6,13H2,1-2H3,(H,29,30)	YAVBCOZWMZVERS-UHFFFAOYSA-N	319929	N-[1-(3- Chloro-5- fluoropyridin- 2-yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 96::US10202369, Example 96::US10472354, Example 96	P2X purinoceptor 2/3	Homo sapiens		 1077							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319929&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397482	384223209							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842633	Cc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-15-10-25-20(12-24-15)13-26-22(28)18-7-19(23-27-11-16(2)31-23)9-21(8-18)30-14-17-3-5-29-6-4-17/h7-12,17H,3-6,13-14H2,1-2H3,(H,26,28)	VSGRXICPAXTBHX-UHFFFAOYSA-N	319930	N-[(5- Methylpyrazin- 2- yl)methyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 97::US10202369, Example 97::US10472354, Example 97	P2X purinoceptor 2/3	Homo sapiens		 1687							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319930&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397814	384223210							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842635	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-22(35-14)18-7-17(8-20(9-18)34-13-16-3-5-33-6-4-16)21(32)31-15(2)19-11-29-23(30-12-19)24(25,26)27/h7-12,15-16H,3-6,13H2,1-2H3,(H,31,32)/t15-/m1/s1	MBJQALPRFLKOPN-OAHLLOKOSA-N	319931	3-(5-Methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl] benzamide::US10174016, Example 98::US10202369, Example 98::US10472354, Example 98	P2X purinoceptor 2/3	Homo sapiens		 19.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319931&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397231	384223211							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842637	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-15-4-5-22(28-27-15)17(3)26-23(29)19-10-20(24-25-13-16(2)32-24)12-21(11-19)31-14-18-6-8-30-9-7-18/h4-5,10-13,17-18H,6-9,14H2,1-3H3,(H,26,29)/t17-/m1/s1	FNFCPAXHCILJLE-QGZVFWFLSA-N	319932	N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- (5-methyl- 1,3-thiazol-2- yl)-5- (tetrahydro- 2H-pyran-4- ylmethoxy) benzamide::US10174016, Example 99::US10202369, Example 99::US10472354, Example 99	P2X purinoceptor 2/3	Homo sapiens		 27.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319932&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397399	384223212							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842639	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C24H23N5O2S/c1-14-5-6-22(29-28-14)17(4)27-23(30)18-10-19(24-26-13-16(3)32-24)12-21(11-18)31-20-7-8-25-15(2)9-20/h5-13,17H,1-4H3,(H,27,30)/t17-/m1/s1	AOJXRFXYSRJHEO-QGZVFWFLSA-N	319933	N-[(1R)-1-(6- Methyl- pyridazin-3- yl)ethyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 100::US10202369, Example 100::US10472354, Example 100	P2X purinoceptor 2/3	Homo sapiens		 16.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319933	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319933&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397202	384223213							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842641	Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C23H21N5O2S/c1-14-4-5-19(28-27-14)13-25-22(29)17-9-18(23-26-12-16(3)31-23)11-21(10-17)30-20-6-7-24-15(2)8-20/h4-12H,13H2,1-3H3,(H,25,29)	XCSQCNBYINKWNK-UHFFFAOYSA-N	319934	N-[(6- Methyl- pyridazin-3- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 101::US10202369, Example 101::US10472354, Example 101	P2X purinoceptor 2/3	Homo sapiens		 60.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319934&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397744	384223214							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842643	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C24H23N5O2S/c1-14-7-20(5-6-25-14)31-21-9-18(8-19(10-21)24-28-12-16(3)32-24)23(30)29-17(4)22-13-26-15(2)11-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1	QEKNBUCJINMCOL-QGZVFWFLSA-N	319935	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 102::US10202369, Example 102::US10472354, Example 102	P2X purinoceptor 2/3	Homo sapiens		 57.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319935&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397697	384223215							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842645	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H20F3N5O2S/c1-13-6-19(4-5-28-13)34-20-8-16(7-17(9-20)22-29-10-14(2)35-22)21(33)32-15(3)18-11-30-23(31-12-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1	JXFGKHKXOUTTKZ-OAHLLOKOSA-N	319936	3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluorometh- yl)pyrimidin- 5- yl]ethyl} benzamide::US10174016, Example 103::US10202369, Example 103::US10472354, Example 103	P2X purinoceptor 2/3	Homo sapiens		 14.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319936&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397214	384223216							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842647	Cc1cnc(s1)-c1cc(Oc2ccnc(C)c2)cc(c1)C(=O)NCc1cnc(C)cn1	InChI=1S/C23H21N5O2S/c1-14-6-20(4-5-24-14)30-21-8-17(7-18(9-21)23-28-11-16(3)31-23)22(29)27-13-19-12-25-15(2)10-26-19/h4-12H,13H2,1-3H3,(H,27,29)	FHRXECCRJLFVTP-UHFFFAOYSA-N	319937	N-[(5- Methylpyrazin- 2- yl)methyl]-3- [(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 104::US10202369, Example 104::US10472354, Example 104	P2X purinoceptor 2/3	Homo sapiens		 377							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319937&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397645	384223217							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842649	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H20F3N5O2S/c1-13-8-18(6-7-28-13)34-19-10-16(9-17(11-19)23-29-12-14(2)35-23)22(33)30-15(3)20-4-5-21(32-31-20)24(25,26)27/h4-12,15H,1-3H3,(H,30,33)/t15-/m1/s1	DZQXNDYGTRQHHO-OAHLLOKOSA-N	319938	3-[(2- Methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [6- (trifluorometh- yl)pyridazin- 3- yl]ethyl} benzamide::US10174016, Example 105::US10202369, Example 105::US10472354, Example 105	P2X purinoceptor 2/3	Homo sapiens		 39.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319938&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397847	384223218							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842651	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C24H23N5O2S/c1-14-7-21(5-6-25-14)31-22-9-18(8-19(10-22)24-28-11-15(2)32-24)23(30)29-16(3)20-12-26-17(4)27-13-20/h5-13,16H,1-4H3,(H,29,30)/t16-/m1/s1	AVOXIOANORGYFZ-MRXNPFEDSA-N	319939	3-[(2-methylpyridin-4-yl)oxy]-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 106::US10202369, Example 106::US10472354, Example 106	P2X purinoceptor 2/3	Homo sapiens		 41.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319939&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397227	384223219							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842653	C[C@@H](NC(=O)c1cc(Oc2ccnc(C)c2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C25H24N4O2S/c1-15-5-6-19(14-27-15)18(4)29-24(30)20-10-21(25-28-13-17(3)32-25)12-23(11-20)31-22-7-8-26-16(2)9-22/h5-14,18H,1-4H3,(H,29,30)/t18-/m1/s1	PNIOXTPFLIQKJT-GOSISDBHSA-N	319940	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]- 3-[(2- methylpyridin- 4-yl)oxy]-5- (5-methyl- 1,3-thiazol-2- yl)benzamide::US10174016, Example 107::US10202369, Example 107::US10472354, Example 107	P2X purinoceptor 2/3	Homo sapiens		 17.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319940&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397329	384223220							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842655	C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H20F3N5O2S/c1-13-4-5-19(12-28-13)34-20-7-16(6-17(8-20)22-29-9-14(2)35-22)21(33)32-15(3)18-10-30-23(31-11-18)24(25,26)27/h4-12,15H,1-3H3,(H,32,33)/t15-/m1/s1	ASXORIIIQIGPLA-OAHLLOKOSA-N	319941	3-[(6-Methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 108::US10202369, Example 108::US10472354, Example 108	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319941&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397249	384223221							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842657	C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C21H20N6O2S2/c1-11-8-23-18(10-22-11)13(3)25-19(28)15-5-16(20-24-9-12(2)30-20)7-17(6-15)29-21-27-26-14(4)31-21/h5-10,13H,1-4H3,(H,25,28)/t13-/m1/s1	SHPJQOXSFBKQMY-CYBMUJFWSA-N	319942	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- [(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 109::US10202369, Example 109::US10472354, Example 109	P2X purinoceptor 2/3	Homo sapiens		 2412							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319942&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397425	384223222							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842659	C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C21H20N6O2S2/c1-11-5-6-18(26-24-11)13(3)23-19(28)15-7-16(20-22-10-12(2)30-20)9-17(8-15)29-21-27-25-14(4)31-21/h5-10,13H,1-4H3,(H,23,28)/t13-/m1/s1	YBUIRLYLJALMRA-CYBMUJFWSA-N	319943	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-[(5-methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2- yl)benzamide::US10174016, Example 110::US10202369, Example 110::US10472354, Example 110	P2X purinoceptor 2/3	Homo sapiens		 1451							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319943&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397265	384223223							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842661	C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H17F3N6O2S2/c1-10-7-25-18(33-10)14-4-13(5-16(6-14)32-20-30-29-12(3)34-20)17(31)28-11(2)15-8-26-19(27-9-15)21(22,23)24/h4-9,11H,1-3H3,(H,28,31)/t11-/m1/s1	FIVDAXBJTLXBHI-LLVKDONJSA-N	319944	3-[(5-Methyl- 1,3,4- thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)- N-[(1R)-1-[2- (trifluorometh- yl)pyrimidin-5- yl]ethyl] benzamide::US10174016, Example 111::US10202369, Example 111::US10472354, Example 111	P2X purinoceptor 2/3	Homo sapiens		 380							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319944	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319944&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397223	384223224							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842663	C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C21H19N5O2S2/c1-12-9-24-18(11-23-12)14(3)26-19(27)15-6-16(20-25-10-13(2)30-20)8-17(7-15)28-21-22-4-5-29-21/h4-11,14H,1-3H3,(H,26,27)/t14-/m1/s1	QJIZPYNDSFDLFQ-CQSZACIVSA-N	319945	N-[(1R)-1-(5- Methylpyrazin- 2-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 112::US10472354, Example 112	P2X purinoceptor 2/3	Homo sapiens		 772							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319945	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319945&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397232	384223225							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842665	C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C21H19N5O2S2/c1-12-4-5-18(26-25-12)14(3)24-19(27)15-8-16(20-23-11-13(2)30-20)10-17(9-15)28-21-22-6-7-29-21/h4-11,14H,1-3H3,(H,24,27)/t14-/m1/s1	KTZHJRKMBNLACT-CQSZACIVSA-N	319946	N-[(1R)-1-(6- Methylpyridazin- 3-yl)ethyl]- 3-(5-methyl- 1,3-thiazol-2- yl)-5-(1,3- thiazol-2- yloxy)benzamide::US10174016, Example 113::US10202369, Example 113::US10472354, Example 113	P2X purinoceptor 2/3	Homo sapiens		 387							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319946	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319946&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397679	384223226							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842667	C[C@@H](NC(=O)c1cc(Oc2nccs2)cc(c1)-c1ncc(C)s1)c1ccc(C)nc1	InChI=1S/C22H20N4O2S2/c1-13-4-5-16(12-24-13)15(3)26-20(27)17-8-18(21-25-11-14(2)30-21)10-19(9-17)28-22-23-6-7-29-22/h4-12,15H,1-3H3,(H,26,27)/t15-/m1/s1	WJNIKDPPMLYZOS-OAHLLOKOSA-N	319947	N-[(1R)-1-(6- Methylpyridin- 3-yl)ethyl]-3- (5-methyl-1,3- thiazol-2-yl)-5- (1,3-thiazol-2- yloxy)benzamide::US10174016, Example 114::US10202369, Example 114::US10472354, Example 114	P2X purinoceptor 2/3	Homo sapiens		 414							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319947&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397612	384223227							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842669	COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(Cl)cn1	InChI=1S/C22H23Cl2N3O3S/c1-13(18-6-5-16(23)10-25-18)27-20(28)14-7-15(21-26-11-19(24)31-21)9-17(8-14)30-12-22(2,3)29-4/h5-11,13H,12H2,1-4H3,(H,27,28)/t13-/m1/s1	MHZRDUGBKYAKKB-CYBMUJFWSA-N	319948	N-[(1R)-1-(5-Chloropyridin-2-yl)ethyl]-3-(5-chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)benzamide::US10174016, Example 115::US10202369, Example 115::US10472354, Example 115	P2X purinoceptor 2/3	Homo sapiens		 187							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319948&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397201	384223228							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842671	COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H22ClF3N4O3S/c1-12(15-8-28-20(29-9-15)22(24,25)26)30-18(31)13-5-14(19-27-10-17(23)34-19)7-16(6-13)33-11-21(2,3)32-4/h5-10,12H,11H2,1-4H3,(H,30,31)/t12-/m1/s1	QSHVLLWXZBADRN-GFCCVEGCSA-N	319949	3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 116::US10202369, Example 116::US10472354, Example 116	P2X purinoceptor 2/3	Homo sapiens		 6430							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319949	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319949&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397235	384223229							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842673	COC(C)(C)COc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C22H25ClN4O3S/c1-13-9-25-18(10-24-13)14(2)27-20(28)15-6-16(21-26-11-19(23)31-21)8-17(7-15)30-12-22(3,4)29-5/h6-11,14H,12H2,1-5H3,(H,27,28)/t14-/m1/s1	IVUVTQZOIPAQFU-CQSZACIVSA-N	319950	3-(5-Chloro-1,3-thiazol-2-yl)-5-(2-methoxy-2-methylpropoxy)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]benzamide::US10174016, Example 117::US10202369, Example 117::US10472354, Example 117	P2X purinoceptor 2/3	Homo sapiens		 883							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319950	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319950&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397711	384223230							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842675	Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C(F)(F)F)nn1	InChI=1S/C23H23F3N4O3S/c1-14-2-3-18(30-29-14)11-27-21(31)16-8-17(22-28-12-20(34-22)23(24,25)26)10-19(9-16)33-13-15-4-6-32-7-5-15/h2-3,8-10,12,15H,4-7,11,13H2,1H3,(H,27,31)	JVFRARFSFIRWBD-UHFFFAOYSA-N	319951	N-[(6-Methylpyridazin-3-yl)methyl]-3-(tetrahydro-2H-pyran-4-ylmethoxy)-5-[5-(trifluoromethyl)-1,3-thiazol-2-yl]benzamide::US10174016, Example 118::US10202369, Example 118::US10472354, Example 118	P2X purinoceptor 2/3	Homo sapiens		 1134							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319951	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319951&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397366	384223231							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842677	Cc1ccc(CNC(=O)c2cc(OCC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1	InChI=1S/C26H30N4O3S/c1-17-5-6-22(30-29-17)14-27-25(31)20-11-21(26-28-15-24(34-26)19-3-2-4-19)13-23(12-20)33-16-18-7-9-32-10-8-18/h5-6,11-13,15,18-19H,2-4,7-10,14,16H2,1H3,(H,27,31)	UIEYRDUAWDAEID-UHFFFAOYSA-N	319952	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 119::US10202369, Example 119::US10472354, Example 119	P2X purinoceptor 2/3	Homo sapiens		 190							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319952	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319952&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397447	384223232							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842679	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C27H29F3N4O3S/c1-16(21-12-32-26(33-13-21)27(28,29)30)34-24(35)19-9-20(25-31-14-23(38-25)18-3-2-4-18)11-22(10-19)37-15-17-5-7-36-8-6-17/h9-14,16-18H,2-8,15H2,1H3,(H,34,35)/t16-/m1/s1	XFOWUTGLWQUPCN-MRXNPFEDSA-N	319953	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-ylmethoxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 120::US10202369, Example 120::US10472354, Example 120	P2X purinoceptor 2/3	Homo sapiens		 104							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319953	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319953&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397437	384223233							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842681	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18+/m1/s1	ZBRXLMDGZXDHGV-MSOLQXFVSA-N	319954	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 121::US10202369, Example 121::US10472354, Example 271	P2X purinoceptor 2/3	Homo sapiens		 279							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319954&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397486	384223234							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842683	Cc1ccc(CNC(=O)c2cc(OC[C@H]3CCOC3)cc(c2)-c2ncc(s2)C2CCC2)nn1	InChI=1S/C25H28N4O3S/c1-16-5-6-21(29-28-16)12-26-24(30)19-9-20(25-27-13-23(33-25)18-3-2-4-18)11-22(10-19)32-15-17-7-8-31-14-17/h5-6,9-11,13,17-18H,2-4,7-8,12,14-15H2,1H3,(H,26,30)/t17-/m0/s1	DCRIJNFHBDAZLX-KRWDZBQOSA-N	319955	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(6-methylpyridazin-3-yl)methyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 122::US10202369, Example 122::US10472354, Example 122	P2X purinoceptor 2/3	Homo sapiens		 1167							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319955	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319955&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397270	384223235							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842685	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16+/m1/s1	JWRPHAGJMIAQMD-CVEARBPZSA-N	319956	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 123::US10202369, Example 123::US10472354, Example 272	P2X purinoceptor 2/3	Homo sapiens		 164							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319956&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397161	384223236							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842687	C[C@@H](NC(=O)c1cc(OCC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)nc1	InChI=1S/C27H32N4O3S/c1-17(23-13-28-18(2)29-14-23)31-26(32)21-10-22(27-30-15-25(35-27)20-4-3-5-20)12-24(11-21)34-16-19-6-8-33-9-7-19/h10-15,17,19-20H,3-9,16H2,1-2H3,(H,31,32)/t17-/m1/s1	WEHPOEFAIDTUPC-QGZVFWFLSA-N	319957	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 124::US10202369, Example 124::US10472354, Example 124	P2X purinoceptor 2/3	Homo sapiens		 165							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319957&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397614	384223237							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842689	CCc1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1	InChI=1S/C25H30N4O3S/c1-4-23-14-28-25(33-23)20-9-19(10-22(11-20)32-15-18-5-7-31-8-6-18)24(30)29-16(2)21-12-26-17(3)27-13-21/h9-14,16,18H,4-8,15H2,1-3H3,(H,29,30)/t16-/m1/s1	DTZIYRRTWOGOEN-MRXNPFEDSA-N	319958	3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 125::US10202369, Example 125::US10472354, Example 125	P2X purinoceptor 2/3	Homo sapiens		 27.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319958&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397256	384223238							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842691	CC(C)c1cnc(s1)-c1cc(OCC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)nc1	InChI=1S/C26H32N4O3S/c1-16(2)24-14-29-26(34-24)21-9-20(10-23(11-21)33-15-19-5-7-32-8-6-19)25(31)30-17(3)22-12-27-18(4)28-13-22/h9-14,16-17,19H,5-8,15H2,1-4H3,(H,30,31)/t17-/m1/s1	OFIYJECBOJUELW-QGZVFWFLSA-N	319959	N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-[5-(propan-2-yl)-1,3-thiazol-2-yl]-5-(tetrahydro-2H-pyran-4-ylmethoxy)benzamide::US10174016, Example 126::US10202369, Example 126::US10472354, Example 126	P2X purinoceptor 2/3	Homo sapiens		 532							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319959&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397136	384223239							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842693	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)19-12-20(26-27-15-24(34-26)18-4-3-5-18)14-22(13-19)33-21-8-10-32-11-9-21/h6-7,12-15,17-18,21H,3-5,8-11H2,1-2H3,(H,28,31)/t17-/m1/s1	WWWCBSCSEOPHLV-QGZVFWFLSA-N	319960	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 127::US10202369, Example 127::US10472354, Example 127	P2X purinoceptor 2/3	Homo sapiens		 536							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319960&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397331	384223240							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842695	CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-14-25-24(32-21)18-11-17(12-20(13-18)31-19-7-9-30-10-8-19)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,11-14,16,19H,4,7-10H2,1-3H3,(H,26,29)/t16-/m1/s1	ZSPSPZOSCRXZOC-MRXNPFEDSA-N	319961	3-(5-Ethyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-(tetrahydro-2H-pyran-4-yloxy)benzamide::US10174016, Example 128::US10202369, Example 128::US10472354, Example 128	P2X purinoceptor 2/3	Homo sapiens		 91.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319961&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397510	384223241							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842697	CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-13-28-22(35-20)16-8-15(9-19(10-16)34-18-4-6-33-7-5-18)21(32)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h8-14,18H,3-7H2,1-2H3,(H,31,32)/t14-/m1/s1	HAECKPIYFMDTPM-CQSZACIVSA-N	319962	3-(5-Ethyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 129::US10202369, Example 129::US10472354, Example 129	P2X purinoceptor 2/3	Homo sapiens		 33.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319962&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397362	384223242							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842699	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C22H24N4O3S/c1-13-9-25-22(30-13)17-6-16(7-20(8-17)29-19-4-5-28-12-19)21(27)26-14(2)18-10-23-15(3)24-11-18/h6-11,14,19H,4-5,12H2,1-3H3,(H,26,27)/t14-,19+/m1/s1	RHVHBKMOULQMJQ-KUHUBIRLSA-N	319963	N-[(1R)-1-(2-Methylpyrimidin-5-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 130::US10202369, Example 130::US10472354, Example 130	P2X purinoceptor 2/3	Homo sapiens		 1349							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319963&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397599	384223243							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842701	C[C@@H](NC(=O)c1cc(Oc2ccc(C)nc2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C24H23N5O2S/c1-14-5-6-20(12-25-14)31-21-8-18(7-19(9-21)24-28-11-16(3)32-24)23(30)29-17(4)22-13-26-15(2)10-27-22/h5-13,17H,1-4H3,(H,29,30)/t17-/m1/s1	PZARJLLATJAKMG-QGZVFWFLSA-N	319964	N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-3-[(6-methylpyridin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 131::US10202369, Example 131::US10472354, Example 131	P2X purinoceptor 2/3	Homo sapiens		 730							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319964&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397434	384223244							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842703	CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(F)cc1Cl	InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(23)8-16(24)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1	YETTUNLUNMEXML-RUINGEJQSA-N	319965	N-[1-(3-Chloro-5-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 132::US10202369, Example 132::US10472354, Example 132	P2X purinoceptor 2/3	Homo sapiens		 2051							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319965&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397504	384223245							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842705	Cc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C21H22N4O3S/c1-13-3-4-17(25-24-13)11-22-20(26)15-7-16(21-23-10-14(2)29-21)9-19(8-15)28-18-5-6-27-12-18/h3-4,7-10,18H,5-6,11-12H2,1-2H3,(H,22,26)/t18-/m0/s1	VKRRMZCTKMLCQJ-SFHVURJKSA-N	319966	N-[(6-Methylpyridazin-3-yl)methyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 133::US10202369, Example 133::US10472354, Example 133	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319966&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397536	384223246							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842707	CC(NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ncc(Cl)cc1F	InChI=1S/C22H21ClFN3O3S/c1-12-9-26-22(31-12)15-5-14(6-18(7-15)30-17-3-4-29-11-17)21(28)27-13(2)20-19(24)8-16(23)10-25-20/h5-10,13,17H,3-4,11H2,1-2H3,(H,27,28)/t13?,17-/m0/s1	DLODQDUFIVUCLQ-RUINGEJQSA-N	319967	N-[1-(5-Chloro-3-fluoropyridin-2-yl)ethyl]-3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]benzamide::US10174016, Example 134::US10202369, Example 134::US10472354, Example 134	P2X purinoceptor 2/3	Homo sapiens		 210							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319967&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397151	384223247							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842709	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18+/m1/s1	KRMAXJMLJAVOGJ-MSOLQXFVSA-N	319968	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 135::US10202369, Example 135::US10472354, Example 270	P2X purinoceptor 2/3	Homo sapiens		 209							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319968&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397422	384223248							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842711	COCCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(C)nc1	InChI=1S/C21H24N4O3S/c1-13-10-24-21(29-13)17-7-16(8-19(9-17)28-6-5-27-4)20(26)25-14(2)18-11-22-15(3)23-12-18/h7-12,14H,5-6H2,1-4H3,(H,25,26)/t14-/m1/s1	NMXUVEDIBFBQMK-CQSZACIVSA-N	319969	3-(2-Methoxyethoxy)-N-[(1R)-1-(2-methylpyrimidin-5-yl)ethyl]-5-(5-methyl-1,3-thiazol-2-yl)benzamide::US10174016, Example 136::US10202369, Example 136::US10472354, Example 136	P2X purinoceptor 2/3	Homo sapiens		 2780							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319969	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319969&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397574	384223249							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842713	C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O4S/c1-16-13-32-24(41-16)19-10-18(23(37)35-17(2)20-14-33-25(34-15-20)28(29,30)31)11-22(12-19)39-21-6-8-36(9-7-21)26(38)40-27(3,4)5/h10-15,17,21H,6-9H2,1-5H3,(H,35,37)/t17-/m1/s1	FLJTWWMLFZUWSL-QGZVFWFLSA-N	319970	US10174016, Example 137::US10472354, Example 137::tert-Butyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate	P2X purinoceptor 2/3	Homo sapiens		 328							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319970&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397466	384223250							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842715	C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-10-28-21(34-13)16-7-15(8-19(9-16)33-18-3-5-27-6-4-18)20(32)31-14(2)17-11-29-22(30-12-17)23(24,25)26/h7-12,14,18,27H,3-6H2,1-2H3,(H,31,32)/t14-/m1/s1	AUEVADIQWKJNQT-CQSZACIVSA-N	319971	3-(5-Methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 138::US10202369, Example 138::US10472354, Example 138	P2X purinoceptor 2/3	Homo sapiens		 559							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319971&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397389	384223251							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842717	C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-11-28-22(35-14)17-8-16(9-20(10-17)34-19-4-6-32(3)7-5-19)21(33)31-15(2)18-12-29-23(30-13-18)24(25,26)27/h8-13,15,19H,4-7H2,1-3H3,(H,31,33)/t15-/m1/s1	BKNIRTNEYAOJDL-OAHLLOKOSA-N	319972	3-[(1-Methylpiperidin-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 139::US10202369, Example 139::US10472354, Example 215	P2X purinoceptor 2/3	Homo sapiens		 962							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319972&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397521	384223252							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842719	CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H30F3N5O2S/c1-15(2)34-7-5-21(6-8-34)36-22-10-18(9-19(11-22)24-30-12-16(3)37-24)23(35)33-17(4)20-13-31-25(32-14-20)26(27,28)29/h9-15,17,21H,5-8H2,1-4H3,(H,33,35)/t17-/m1/s1	JAJQPYKLEVBCIY-QGZVFWFLSA-N	319973	3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 140::US10202369, Example 140::US10472354, Example 140	P2X purinoceptor 2/3	Homo sapiens		 1295							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319973&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397336	384223253							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842721	C[C@@H](NC(=O)c1cc(O[C@@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18-/m1/s1	RNHSPVKPEXJLAD-RDTXWAMCSA-N	319974	3-{[(3R)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 141::US10202369, Example 141::US10472354, Example 141	P2X purinoceptor 2/3	Homo sapiens		 2201							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319974&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397272	384223254							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842723	C[C@@H](NC(=O)c1cc(O[C@H]2CCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-9-27-21(34-13)16-6-15(7-19(8-16)33-18-4-5-31(3)12-18)20(32)30-14(2)17-10-28-22(29-11-17)23(24,25)26/h6-11,14,18H,4-5,12H2,1-3H3,(H,30,32)/t14-,18+/m1/s1	RNHSPVKPEXJLAD-KDOFPFPSSA-N	319975	3-{[(3S)-1-Methylpyrrolidin-3-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 142::US10202369, Example 142::US10472354, Example 142	P2X purinoceptor 2/3	Homo sapiens		 222							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319975&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397181	384223255							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842725	C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H22F3N5O2S/c1-12-7-26-20(33-12)15-4-14(5-17(6-15)32-18-10-30(3)11-18)19(31)29-13(2)16-8-27-21(28-9-16)22(23,24)25/h4-9,13,18H,10-11H2,1-3H3,(H,29,31)/t13-/m1/s1	NFRXFSQBXDHWHW-CYBMUJFWSA-N	319976	3-[(1-Methylazetidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 143::US10202369, Example 143::US10472354, Example 143	P2X purinoceptor 2/3	Homo sapiens		 3047							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319976&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397519	384223256							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842727	C[C@H](NC(=O)c1cc(OCC#C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H17F3N4O2S/c1-4-5-30-17-7-14(6-15(8-17)19-25-9-12(2)31-19)18(29)28-13(3)16-10-26-20(27-11-16)21(22,23)24/h1,6-11,13H,5H2,2-3H3,(H,28,29)/t13-/m0/s1	BTRSFHCVZJPJKT-ZDUSSCGKSA-N	319977	3-(5-Methyl-1,3-thiazol-2-yl)-5-(prop-2-yn-1-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 144::US10202369, Example 144::US10472354, Example 144	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319977&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397460	384223257							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842729	C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-10-27-21(34-13)16-7-15(8-19(9-16)33-18-3-5-32-6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m0/s1	WGQQHPGXKFPPTQ-AWEZNQCLSA-N	319978	3-(5-Methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{(1S)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 145::US10202369, Example 145::US10472354, Example 145	P2X purinoceptor 2/3	Homo sapiens		 4461							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319978&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397306	384223258							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842731	C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C3)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C29H32F3N5O4S/c1-16-11-33-24(42-16)19-6-18(23(38)36-17(2)20-12-34-25(35-13-20)29(30,31)32)7-21(8-19)40-22-9-28(10-22)14-37(15-28)26(39)41-27(3,4)5/h6-8,11-13,17,22H,9-10,14-15H2,1-5H3,(H,36,38)/t17-/m1/s1	GOFUMWOIVIXXIJ-QGZVFWFLSA-N	319979	US10174016, Example 146::US10202369, Example 146::US10472354, Example 146::tert-butyl 6-[3-(5- methyl-1,3- thiazol-2-yl)-5- ({(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}carbamoyl) phenoxy]-2- azaspiro[3.3]heptane- 2-carboxylate	P2X purinoceptor 2/3	Homo sapiens		 159							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319979	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319979&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397340	384223259							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842733	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(cn1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-8-28-21(33-12)15-5-14(6-17(7-15)32-16-3-4-31-11-16)20(30)29-13(2)18-9-27-19(10-26-18)22(23,24)25/h5-10,13,16H,3-4,11H2,1-2H3,(H,29,30)/t13-,16-/m1/s1	DVMONFUPUPPMFW-CZUORRHYSA-N	319980	3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [5- (trifluoromethyl) pyrazin-2- yl]ethyl}benzamide::US10174016, Example 147::US10202369, Example 147::US10472354, Example 147	P2X purinoceptor 2/3	Homo sapiens		 132							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319980	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319980&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397189	384223260							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842735	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C22H20F3N3O3S/c1-12-8-27-21(32-12)16-5-15(6-17(7-16)31-18-10-30-11-18)20(29)28-13(2)14-3-4-19(26-9-14)22(23,24)25/h3-9,13,18H,10-11H2,1-2H3,(H,28,29)/t13-/m1/s1	NAXHTXVAPBZYNR-CYBMUJFWSA-N	319981	3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 148::US10202369, Example 148::US10472354, Example 148	P2X purinoceptor 2/3	Homo sapiens		 794							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319981	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319981&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397138	384223261							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842737	C[C@@H](NC(=O)c1cc(OC23CCN(CC2)CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-15-12-29-22(36-15)18-9-17(10-20(11-18)35-24-3-6-33(7-4-24)8-5-24)21(34)32-16(2)19-13-30-23(31-14-19)25(26,27)28/h9-14,16H,3-8H2,1-2H3,(H,32,34)/t16-/m1/s1	RAGSAJSSGMANHP-MRXNPFEDSA-N	319982	3-(1- azabicyclo[2.2.2] oct-4-yloxy)-5-(5- methyl-1,3- thiazol-3-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 149::US10202369, Example 149::US10472354, Example 149	P2X purinoceptor 2/3	Homo sapiens		 936							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319982	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319982&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397715	384223262							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842739	C[C@@H](NC(=O)c1cc(OC2CCN(CC2)C(C)=O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O3S/c1-14-11-29-23(37-14)18-8-17(9-21(10-18)36-20-4-6-33(7-5-20)16(3)34)22(35)32-15(2)19-12-30-24(31-13-19)25(26,27)28/h8-13,15,20H,4-7H2,1-3H3,(H,32,35)/t15-/m1/s1	ISMQQTCWBNBFKY-OAHLLOKOSA-N	319983	3-[(1- acetylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 150::US10202369, Example 150::US10472354, Example 150	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319983	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319983&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397215	384223263							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842741	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F	InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17+/m1/s1	AUVRCFBFFFYNAV-DYVFJYSZSA-N	319984	N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 151::US10202369, Example 151::US10472354, Example 151	P2X purinoceptor 2/3	Homo sapiens		 333							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319984	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319984&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397480	384223264							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842743	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F	InChI=1S/C21H20F2N4O3S/c1-11-6-26-21(31-11)14-3-13(4-16(5-14)30-17-9-29-10-17)20(28)27-12(2)15-7-24-19(18(22)23)25-8-15/h3-8,12,17-18H,9-10H2,1-2H3,(H,27,28)/t12-/m1/s1	YTKWIWSPGJOVJL-GFCCVEGCSA-N	319985	N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 152::US10202369, Example 152::US10472354, Example 152	P2X purinoceptor 2/3	Homo sapiens		 523							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319985	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319985&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397528	384223265							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842745	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F	InChI=1S/C22H22F2N4O3S/c1-12-8-27-22(32-12)15-5-14(6-18(7-15)31-17-3-4-30-11-17)21(29)28-13(2)16-9-25-20(19(23)24)26-10-16/h5-10,13,17,19H,3-4,11H2,1-2H3,(H,28,29)/t13-,17-/m1/s1	AUVRCFBFFFYNAV-CXAGYDPISA-N	319986	N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 153::US10202369, Example 153::US10472354, Example 153	P2X purinoceptor 2/3	Homo sapiens		 304							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319986	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319986&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397665	384223266							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842747	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)F	InChI=1S/C23H24F2N4O3S/c1-13-10-28-23(33-13)16-7-15(8-19(9-16)32-18-3-5-31-6-4-18)22(30)29-14(2)17-11-26-21(20(24)25)27-12-17/h7-12,14,18,20H,3-6H2,1-2H3,(H,29,30)/t14-/m1/s1	RQWRZCMIWXGQJP-CQSZACIVSA-N	319987	N-{(1R)-1-[2- (difluoromethyl) pyrimidin-5- yl]ethyl}-3-(5- methyl-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 154::US10202369, Example 154::US10472354, Example 154	P2X purinoceptor 2/3	Homo sapiens		 130							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319987	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319987&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397560	384223267							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842749	C[C@@H](NC(=O)c1cc(O[C@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1	DNVWWBHMIGZIMX-BEFAXECRSA-N	319988	3-{[(3S)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 155::US10174016, Example 221::US10202369, Example 155::US10472354, Example 155	P2X purinoceptor 2/3	Homo sapiens		 2267							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319988	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319988&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397794	384223268							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842751	C[C@@H](NC(=O)c1cc(OC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-7-26-19(33-12)15-4-14(5-17(6-15)32-21(3)10-31-11-21)18(30)29-13(2)16-8-27-20(28-9-16)22(23,24)25/h4-9,13H,10-11H2,1-3H3,(H,29,30)/t13-/m1/s1	OYDLDEWAXBGGBJ-CYBMUJFWSA-N	319989	3-[(3- methyloxetan-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 156::US10202369, Example 156::US10472354, Example 156	P2X purinoceptor 2/3	Homo sapiens		 163							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319989	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319989&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397627	384223269							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842753	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C23H22F3N3O3S/c1-13-10-28-22(33-13)17-7-16(8-19(9-17)32-18-5-6-31-12-18)21(30)29-14(2)15-3-4-20(27-11-15)23(24,25)26/h3-4,7-11,14,18H,5-6,12H2,1-2H3,(H,29,30)/t14-,18-/m1/s1	RHAXZNLWUJRHEA-RDTXWAMCSA-N	319990	3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 157::US10202369, Example 157::US10472354, Example 157	P2X purinoceptor 2/3	Homo sapiens		 534							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319990	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319990&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397372	384223270							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842755	C[C@@H](NC(=O)c1cc(O[C@@H]2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1	DNVWWBHMIGZIMX-DNVCBOLYSA-N	319991	3-{[(3R)-1- methylpiperidin-3- yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 158::US10174016, Example 220::US10202369, Example 158::US10472354, Example 158	P2X purinoceptor 2/3	Homo sapiens		 1939							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319991	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319991&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397414	384223271							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842757	C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H20F3N7O2S/c1-13-8-27-20(35-13)16-5-15(6-18(7-16)34-4-3-32-12-26-11-30-32)19(33)31-14(2)17-9-28-21(29-10-17)22(23,24)25/h5-12,14H,3-4H2,1-2H3,(H,31,33)/t14-/m1/s1	HYNLHPVSAUUUKN-CQSZACIVSA-N	319992	3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 159::US10202369, Example 159::US10472354, Example 159	P2X purinoceptor 2/3	Homo sapiens		 1233							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319992	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319992&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397126	384223272							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842759	C[C@@H](NC(=O)c1cc(OCCn2cncn2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C23H21F3N6O2S/c1-14-10-29-22(35-14)18-7-17(8-19(9-18)34-6-5-32-13-27-12-30-32)21(33)31-15(2)16-3-4-20(28-11-16)23(24,25)26/h3-4,7-13,15H,5-6H2,1-2H3,(H,31,33)/t15-/m1/s1	ZEDPNXXTTLJFPM-OAHLLOKOSA-N	319993	3-(5-methyl-1,3- thiazol-2-yl)-5-[2- (1H-1,2,4-triazol- 1-yl)ethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 160::US10202369, Example 160::US10472354, Example 160	P2X purinoceptor 2/3	Homo sapiens		 1007							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319993	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319993&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397838	384223273							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842761	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C21H19F3N4O3S/c1-11-8-25-20(32-11)14-5-13(6-15(7-14)31-16-9-30-10-16)19(29)26-12(2)17-3-4-18(28-27-17)21(22,23)24/h3-8,12,16H,9-10H2,1-2H3,(H,26,29)/t12-/m1/s1	GINDYDBHFAVPIL-GFCCVEGCSA-N	319994	3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 161::US10202369, Example 161::US10472354, Example 161	P2X purinoceptor 2/3	Homo sapiens		 632							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319994	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319994&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397757	384223274							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842763	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m0/s1	FSGDRFBLPAILDE-HSBZDZAISA-N	319996	US10174016, Example 163::US10202369, Example 340::US10472354, Example 162	P2X purinoceptor 2/3	Homo sapiens		 74.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319996	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319996&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134328174	384223276							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842765	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1	FSGDRFBLPAILDE-IYXRBSQSSA-N	319995	3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397269	384223275							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842767	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F	InChI=1S/C22H21F2N3O3S/c1-12-8-26-22(31-12)16-5-15(6-17(7-16)30-18-10-29-11-18)21(28)27-13(2)14-3-4-19(20(23)24)25-9-14/h3-9,13,18,20H,10-11H2,1-2H3,(H,27,28)/t13-/m1/s1	VIFFUASYGYMCSF-CYBMUJFWSA-N	319997	N-{[(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3- yloxy)benzamide::US10174016, Example 164::US10202369, Example 164::US10472354, Example 164	P2X purinoceptor 2/3	Homo sapiens		 1107							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319997	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319997&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397252	384223277							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842769	C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H](C2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-13-10-28-22(35-13)16-5-15(6-19(7-16)34-20-8-18(9-20)32(3)4)21(33)31-14(2)17-11-29-23(30-12-17)24(25,26)27/h5-7,10-12,14,18,20H,8-9H2,1-4H3,(H,31,33)/t14-,18-,20-/m1/s1	AGHYBRFMKRJHNY-LXGCGDOSSA-N	319998	3-{[trans-3- (dimethylamino) cyclobutyl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 165::US10202369, Example 165::US10472354, Example 165	P2X purinoceptor 2/3	Homo sapiens		 1923							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319998	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319998&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397549	384223278							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842771	Cc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F	InChI=1S/C21H19F3N4O3S/c1-12-7-26-19(32-12)15-4-14(5-17(6-15)31-16-2-3-30-11-16)18(29)25-8-13-9-27-20(28-10-13)21(22,23)24/h4-7,9-10,16H,2-3,8,11H2,1H3,(H,25,29)/t16-/m1/s1	MLKRPMMAEMGGNI-MRXNPFEDSA-N	319999	3-(5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 166::US10202369, Example 166::US10472354, Example 166	P2X purinoceptor 2/3	Homo sapiens		 461							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319999	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319999&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397360	384223279							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842773	Cc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)NCc1cnc(nc1)C(F)(F)F	InChI=1S/C20H17F3N4O3S/c1-11-5-25-18(31-11)14-2-13(3-15(4-14)30-16-9-29-10-16)17(28)24-6-12-7-26-19(27-8-12)20(21,22)23/h2-5,7-8,16H,6,9-10H2,1H3,(H,24,28)	AWMOXCQCRBHEDH-UHFFFAOYSA-N	320000	3-(5-methyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{[2- (trifluoromethyl) pyrimidin-5- yl]methyl}benzamide::US10174016, Example 167::US10202369, Example 167::US10472354, Example 167	P2X purinoceptor 2/3	Homo sapiens		 893							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320000	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320000&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397228	384223280							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842775	C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21+/m1/s1	XGNFOBIXAZWFEF-VFNWGFHPSA-N	320001	3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 168::US10202369, Example 168::US10472354, Example 168	P2X purinoceptor 2/3	Homo sapiens		 1600							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320001	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320001&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397190	384223281							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842777	CCc1cnc(s1)-c1cc(OC2COC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-3-18-9-26-20(33-18)14-4-13(5-16(6-14)32-17-10-31-11-17)19(30)29-12(2)15-7-27-21(28-8-15)22(23,24)25/h4-9,12,17H,3,10-11H2,1-2H3,(H,29,30)/t12-/m1/s1	KJLXSAGNAKDMHX-GFCCVEGCSA-N	320002	3-(5-ethyl-1,3- thiazol-2-yl)-5- (oxetan-3-yloxy)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 169::US10202369, Example 169::US10472354, Example 169	P2X purinoceptor 2/3	Homo sapiens		 70.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320002	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320002&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397192	384223282							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842779	C[C@@H](NC(=O)c1cc(Oc2ccc(C)nn2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H19F3N6O2S/c1-12-4-5-19(32-31-12)34-18-7-15(6-16(8-18)21-27-9-13(2)35-21)20(33)30-14(3)17-10-28-22(29-11-17)23(24,25)26/h4-11,14H,1-3H3,(H,30,33)/t14-/m1/s1	YBWKZVABJNKBEG-CQSZACIVSA-N	320003	3-[(6- methylpyridazin-3- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 170::US10202369, Example 170::US10472354, Example 170	P2X purinoceptor 2/3	Homo sapiens		 2020							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320003	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320003&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397298	384223283							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842781	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)F	InChI=1S/C23H23F2N3O3S/c1-13-10-27-23(32-13)17-7-16(8-19(9-17)31-18-5-6-30-12-18)22(29)28-14(2)15-3-4-20(21(24)25)26-11-15/h3-4,7-11,14,18,21H,5-6,12H2,1-2H3,(H,28,29)/t14-,18-/m1/s1	UIFKRKFOSZCXTP-RDTXWAMCSA-N	320004	N-{(1R)-1-[6- (difluoromethyl) pyridin-3-yl]ethyl}-3- (5-methyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 171::US10202369, Example 171::US10472354, Example 171	P2X purinoceptor 2/3	Homo sapiens		 573							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320004	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320004&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397544	384223284							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842783	C[C@@H](NC(=O)c1cc(O[C@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22+/m1/s1	BTZKHRISYBAOIH-ZHRRBRCNSA-N	320005	3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 172::US10202369, Example 172::US10472354, Example 172	P2X purinoceptor 2/3	Homo sapiens		 2107							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320005	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320005&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397643	384223285							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842785	CCc1cnc(s1)-c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22-/m1/s1	SVMXJSAEFPTNIN-IVZQSRNASA-N	320006	3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 173::US10202369, Example 173::US10472354, Example 173	P2X purinoceptor 2/3	Homo sapiens		 311							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320006	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320006&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397592	384223286							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842787	CCc1cnc(s1)-c1cc(O[C@H]2CN3CCC2CC3)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O2S/c1-3-21-13-30-24(37-21)18-8-17(9-20(10-18)36-22-14-34-6-4-16(22)5-7-34)23(35)33-15(2)19-11-31-25(32-12-19)26(27,28)29/h8-13,15-16,22H,3-7,14H2,1-2H3,(H,33,35)/t15-,22+/m1/s1	SVMXJSAEFPTNIN-QRQCRPRQSA-N	320007	3-[(3R)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- ethyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 174::US10202369, Example 174::US10472354, Example 174	P2X purinoceptor 2/3	Homo sapiens		 790							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320007	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320007&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397479	384223287							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842789	C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O2S/c1-15-12-31-25(36-15)20-9-19(10-21(11-20)35-22-14-33-7-5-17(22)6-8-33)24(34)32-16(2)18-3-4-23(30-13-18)26(27,28)29/h3-4,9-13,16-17,22H,5-8,14H2,1-2H3,(H,32,34)/t16-,22-/m1/s1	BTZKHRISYBAOIH-OPAMFIHVSA-N	320008	3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 175::US10202369, Example 175::US10472354, Example 175	P2X purinoceptor 2/3	Homo sapiens		 1274							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320008	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320008&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397558	384223288							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842791	C[C@@H](NC(=O)c1cc(Oc2nnc(C)s2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C22H18F3N5O2S2/c1-11-9-27-20(33-11)16-6-15(7-17(8-16)32-21-30-29-13(3)34-21)19(31)28-12(2)14-4-5-18(26-10-14)22(23,24)25/h4-10,12H,1-3H3,(H,28,31)/t12-/m1/s1	IWXLKQRNUPTLAV-GFCCVEGCSA-N	320009	3-[(5-methyl- 1,3,4-thiadiazol-2- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 176::US10202369, Example 176::US10472354, Example 176	P2X purinoceptor 2/3	Homo sapiens		 607							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320009	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320009&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397692	384223289							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842793	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20-/m1/s1	LZEBVIBIWJOALL-FOIQADDNSA-N	320010	3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl}benzamide::US10174016, Example 177::US10202369, Example 177::US10472354, Example 177	P2X purinoceptor 2/3	Homo sapiens		 887							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320010	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320010&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397515	384223290							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842795	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19-/m1/s1	NQEFGEXCJWOEFF-AUUYWEPGSA-N	320011	3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 178::US10202369, Example 178::US10472354, Example 178	P2X purinoceptor 2/3	Homo sapiens		 1880							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320011	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320011&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397229	384223291							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842797	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18-/m1/s1	PZDPWIRLHUGUOG-RDTXWAMCSA-N	320012	3-[(2R)-1,4-dioxan-2- ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl]ethyl} benzamide::US10174016, Example 179::US10202369, Example 179::US10472354, Example 179	P2X purinoceptor 2/3	Homo sapiens		 703							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320012	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320012&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397371	384223292							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842799	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C24H24F3N3O4S/c1-14-10-29-23(35-14)18-7-17(8-19(9-18)34-13-20-12-32-5-6-33-20)22(31)30-15(2)16-3-4-21(28-11-16)24(25,26)27/h3-4,7-11,15,20H,5-6,12-13H2,1-2H3,(H,30,31)/t15-,20+/m1/s1	LZEBVIBIWJOALL-QRWLVFNGSA-N	320013	3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3-thiazol-2-yl)- N-{(1R)-1-[6- (trifluoromethyl)pyridin- 3-yl]ethyl}benzamide::US10174016, Example 180::US10202369, Example 180::US10472354, Example 180	P2X purinoceptor 2/3	Homo sapiens		 1399							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320013	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320013&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397137	384223293							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842801	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O4S/c1-13-8-27-21(35-13)16-5-15(6-18(7-16)34-12-19-11-32-3-4-33-19)20(31)30-14(2)17-9-28-22(29-10-17)23(24,25)26/h5-10,14,19H,3-4,11-12H2,1-2H3,(H,30,31)/t14-,19+/m1/s1	NQEFGEXCJWOEFF-KUHUBIRLSA-N	320014	3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 181::US10202369, Example 181::US10472354, Example 181	P2X purinoceptor 2/3	Homo sapiens		 1181							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320014	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320014&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397128	384223294							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842803	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCO2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H23F3N4O4S/c1-13-10-27-22(35-13)16-7-15(8-17(9-16)34-12-18-11-32-5-6-33-18)21(31)28-14(2)19-3-4-20(30-29-19)23(24,25)26/h3-4,7-10,14,18H,5-6,11-12H2,1-2H3,(H,28,31)/t14-,18+/m1/s1	PZDPWIRLHUGUOG-KDOFPFPSSA-N	320015	3-[(2S)-1,4-dioxan- 2-ylmethoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 182::US10202369, Example 182::US10472354, Example 182	P2X purinoceptor 2/3	Homo sapiens		 1943							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320015	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320015&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397642	384223295							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842805	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1	LMHZXBDHIYABCN-IYXRBSQSSA-N	320016	Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231	P2X purinoceptor 2/3	Homo sapiens		 398							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397175	384223296							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842807	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1	QTLJKKFADUZLKR-VOMCLLRMSA-N	320017	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188	P2X purinoceptor 2/3	Homo sapiens		 128							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397494	384223297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842809	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1	QTLJKKFADUZLKR-VOMCLLRMSA-N	320017	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188	P2X purinoceptor 2/3	Homo sapiens		 123							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397494	384223297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842811	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F	InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1	HTVWJAQZHONFAU-PNESKVBLSA-N	320019	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189	P2X purinoceptor 2/3	Homo sapiens		 247							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397322	384223298							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842813	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1	QTLJKKFADUZLKR-VOMCLLRMSA-N	320017	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188	P2X purinoceptor 2/3	Homo sapiens		 218							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397494	384223297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842815	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C21H20ClF3N4O3S/c1-10(15-7-27-20(28-8-15)21(23,24)25)29-18(31)13-4-14(19-26-9-17(22)33-19)6-16(5-13)32-12(3)11(2)30/h4-12,30H,1-3H3,(H,29,31)/t10-,11?,12?/m1/s1	QTLJKKFADUZLKR-VOMCLLRMSA-N	320017	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 184::US10174016, Example 185::US10174016, Example 187::US10174016, Example 188::US10202369, Example 188::US10472354, Example 188	P2X purinoceptor 2/3	Homo sapiens		 164							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320017	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320017&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397494	384223297							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842817	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(Cl)s1)C(=O)N[C@H](C)c1ccc(nc1)C(F)(F)F	InChI=1S/C22H21ClF3N3O3S/c1-11(14-4-5-18(27-9-14)22(24,25)26)29-20(31)15-6-16(21-28-10-19(23)33-21)8-17(7-15)32-13(3)12(2)30/h4-13,30H,1-3H3,(H,29,31)/t11-,12?,13?/m1/s1	HTVWJAQZHONFAU-PNESKVBLSA-N	320019	Trans Isomer 1; 3- (5-chloro-1,3- thiazol-2-yl)-5-{[3- hydroxybutan-2- yl]oxy}-N-{(1R)-1- [6-(trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 186::US10174016, Example 189::US10202369, Example 189::US10472354, Example 189	P2X purinoceptor 2/3	Homo sapiens		 258							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320019	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320019&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397322	384223298							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842819	C[C@@H](NC(=O)c1cc(OC2CCCN(C2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O4S/c1-16-12-32-24(41-16)19-9-18(23(37)35-17(2)20-13-33-25(34-14-20)28(29,30)31)10-22(11-19)39-21-7-6-8-36(15-21)26(38)40-27(3,4)5/h9-14,17,21H,6-8,15H2,1-5H3,(H,35,37)/t17-,21?/m1/s1	GMVSECYUKAWWNE-OQHSHRKDSA-N	320023	US10174016, Example 190::US10202369, Example 190::US10472354, Example 190::tert-Butyl (3R)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate, as a mixture of diastereoisomers	P2X purinoceptor 2/3	Homo sapiens		 207							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320023	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320023&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338447	384223299							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842821	CC#CCOc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C22H22N4O2S/c1-5-6-9-28-19-11-17(10-18(12-19)22-23-13-15(3)29-22)21(27)24-16(4)20-8-7-14(2)25-26-20/h7-8,10-13,16H,9H2,1-4H3,(H,24,27)/t16-/m1/s1	WEKOJPFCJMIPGB-MRXNPFEDSA-N	320024	3-(but-2-yn-1- yloxy)-N-[(1R)- 1-(6- methylpyridazin- 3- yl)ethyl]-5- (5-methyl- 1,3-thiazol-2-yl) benzamide::US10174016, Example 191::US10202369, Example 191::US10472354, Example 191	P2X purinoceptor 2/3	Homo sapiens		 364							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320024	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320024&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397657	384223300							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842823	C[C@@H](NC(=O)c1cc(O[C@@H]2CN3CCC2CC3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-14-10-29-23(36-14)18-7-17(8-20(9-18)35-21-13-33-5-3-16(21)4-6-33)22(34)32-15(2)19-11-30-24(31-12-19)25(26,27)28/h7-12,15-16,21H,3-6,13H2,1-2H3,(H,32,34)/t15-,21-/m1/s1	XGNFOBIXAZWFEF-QVKFZJNVSA-N	320025	3-[(3S)-1- azabicyclo[2.2.2] oct-3-yloxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl] ethyl} benzamide::US10174016, Example 192::US10202369, Example 192::US10472354, Example 192	P2X purinoceptor 2/3	Homo sapiens		 910							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320025	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320025&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397263	384223301							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842825	C[C@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m0/s1	CAKLWYTTWVXMCY-JTQLQIEISA-N	320027	US10174016, Example 194::US10202369, Example 193::US10472354, Example 193	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320027	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320027&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374897	384223303							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842827	C[C@@H](NC(=O)c1cc(OC2COC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C19H17F3N4O3S2/c1-9-6-23-17(30-9)12-3-11(4-13(5-12)29-14-7-28-8-14)15(27)24-10(2)16-25-26-18(31-16)19(20,21)22/h3-6,10,14H,7-8H2,1-2H3,(H,24,27)/t10-/m1/s1	CAKLWYTTWVXMCY-SNVBAGLBSA-N	320026	3-(5-Methyl-1,3-thiazol-2-yl)-5-(oxetan-3-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 193::US10202369, Example 194::US10472354, Example 194	P2X purinoceptor 2/3	Homo sapiens		 579							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320026	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320026&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374896	384223302							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842829	C[C@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m0/s1	NWTVSPCFEGLAFO-LBPRGKRZSA-N	320029	US10174016, Example 196::US10202369, Example 195::US10472354, Example 195	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320029	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320029&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374899	384223305							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842831	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C21H21F3N4O3S2/c1-11-10-25-19(32-11)14-7-13(8-16(9-14)31-15-3-5-30-6-4-15)17(29)26-12(2)18-27-28-20(33-18)21(22,23)24/h7-10,12,15H,3-6H2,1-2H3,(H,26,29)/t12-/m1/s1	NWTVSPCFEGLAFO-GFCCVEGCSA-N	320028	3-(5-methyl-1,3-thiazol-2-yl)-5-(tetrahydro-2H-pyran-4-yloxy)-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 195::US10202369, Example 196::US10472354, Example 196	P2X purinoceptor 2/3	Homo sapiens		 293							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320028	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320028&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374898	384223304							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842833	C[C@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m0/s1	SHLRNWXFYHGFLL-SMDDNHRTSA-N	320031	US10174016, Example 198::US10202369, Example 197::US10472354, Example 197	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320031	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320031&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374900	384223307							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842835	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m1/s1	SHLRNWXFYHGFLL-BXUZGUMPSA-N	320030	3-(5-methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 197::US10202369, Example 198::US10472354, Example 198	P2X purinoceptor 2/3	Homo sapiens		 245							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320030&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397585	384223306							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842837	C[C@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14-/m0/s1	SHLRNWXFYHGFLL-FZMZJTMJSA-N	320033	US10174016, Example 200::US10202369, Example 199::US10472354, Example 199	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320033	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320033&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374901	384223309							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842839	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1nnc(s1)C(F)(F)F	InChI=1S/C20H19F3N4O3S2/c1-10-8-24-18(31-10)13-5-12(6-15(7-13)30-14-3-4-29-9-14)16(28)25-11(2)17-26-27-19(32-17)20(21,22)23/h5-8,11,14H,3-4,9H2,1-2H3,(H,25,28)/t11-,14+/m1/s1	SHLRNWXFYHGFLL-RISCZKNCSA-N	320032	3-(5-methyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-yloxy]-N-{1-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]ethyl}benzamide::US10174016, Example 199::US10202369, Example 200::US10472354, Example 200	P2X purinoceptor 2/3	Homo sapiens		 546							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320032	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320032&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397243	384223308							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842841	C[C@@H](NC(=O)c1cc(OC2CCNCC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-12-28-22(34-13)16-9-15(10-18(11-16)33-17-5-7-27-8-6-17)21(32)29-14(2)19-3-4-20(31-30-19)23(24,25)26/h3-4,9-12,14,17,27H,5-8H2,1-2H3,(H,29,32)/t14-/m1/s1	JTGZQMREWDOCMX-CQSZACIVSA-N	320034	3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-4-yloxy)-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 201::US10202369, Example 201::US10472354, Example 201	P2X purinoceptor 2/3	Homo sapiens		 1854							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320034	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320034&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397404	384223310							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842843	C[C@@H](NC(=O)c1cc(OC2CC3(CNC3)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O2S/c1-13-8-29-21(35-13)16-3-15(4-18(5-16)34-19-6-23(7-19)11-28-12-23)20(33)32-14(2)17-9-30-22(31-10-17)24(25,26)27/h3-5,8-10,14,19,28H,6-7,11-12H2,1-2H3,(H,32,33)/t14-/m1/s1	KMHSWHWDZALJOK-CQSZACIVSA-N	320035	3-(2- azaspiro[3.3] hept- 6-yloxy)-5-(5- methyl-1,3- thiazol-2- yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 202::US10202369, Example 202::US10472354, Example 202	P2X purinoceptor 2/3	Homo sapiens		 1710							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320035	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320035&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397731	384223311							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842845	C[C@@H](NC(=O)c1cc(O[C@H]2CCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H22F3N5O2S/c1-12-8-27-20(33-12)15-5-14(6-18(7-15)32-17-3-4-26-11-17)19(31)30-13(2)16-9-28-21(29-10-16)22(23,24)25/h5-10,13,17,26H,3-4,11H2,1-2H3,(H,30,31)/t13-,17+/m1/s1	IUOVXWVSORDTAX-DYVFJYSZSA-N	320036	3-(5-methyl- 1,3-thiazol-2- yl)-5-[(3S)- pyrrolidin-3- yloxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 203::US10202369, Example 203::US10472354, Example 203	P2X purinoceptor 2/3	Homo sapiens		 1561							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320036	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320036&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397829	384223312							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842847	C[C@@H](NC(=O)c1cc(OC2CCNCC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F4N5O2S/c1-12-8-29-21(35-12)15-5-14(6-17(7-15)34-19-3-4-28-11-18(19)24)20(33)32-13(2)16-9-30-22(31-10-16)23(25,26)27/h5-10,13,18-19,28H,3-4,11H2,1-2H3,(H,32,33)/t13-,18?,19?/m1/s1	IVYMHMMQRKFONZ-XYJCDUHRSA-N	320037	3-{[3- fluoropiperidin- 4-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of cis isomers::US10174016, Example 204::US10202369, Example 204::US10472354, Example 204	P2X purinoceptor 2/3	Homo sapiens		 82.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320037	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320037&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397537	384223313							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842849	C[C@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m0/s1	YIMSHVDFMHXVTO-PIVQAISJSA-N	322395	US10183937, Example 206::US10202369, Example 206::US10472354, Example 205	P2X purinoceptor 2/3	Homo sapiens		 272							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322395	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322395&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375407	384225458							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842851	C[C@@H](NC(=O)c1cc(OC2CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O2S/c1-13-9-28-21(34-13)16-6-15(7-19(8-16)33-18-4-3-5-27-12-18)20(32)31-14(2)17-10-29-22(30-11-17)23(24,25)26/h6-11,14,18,27H,3-5,12H2,1-2H3,(H,31,32)/t14-,18?/m1/s1	YIMSHVDFMHXVTO-IKJXHCRLSA-N	322394	3-(5-methyl-1,3-thiazol-2-yl)-5-(piperidin-3-yloxy)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 205::US10202369, Example 205::US10472354, Example 206	P2X purinoceptor 2/3	Homo sapiens		 1676							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322394	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322394&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397478	384225457							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842853	C[C@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m0/s1	RLIMWYRKEDYMPQ-LJSZUPLFSA-N	322397	US10183937, Example 208::US10202369, Example 208::US10472354, Example 207	P2X purinoceptor 2/3	Homo sapiens		 87.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322397	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322397&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375408	384225460							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842855	C[C@@H](NC(=O)c1cc(OC2CCNC(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H23F6N5O2S/c1-12-9-32-21(38-12)15-5-14(6-18(7-15)37-17-3-4-31-19(8-17)23(25,26)27)20(36)35-13(2)16-10-33-22(34-11-16)24(28,29)30/h5-7,9-11,13,17,19,31H,3-4,8H2,1-2H3,(H,35,36)/t13-,17?,19?/m1/s1	RLIMWYRKEDYMPQ-UYCDIGJJSA-N	322396	3-(5-methyl-1,3-thiazol-2-yl)-5-{[2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 207::US10202369, Example 207::US10472354, Example 208	P2X purinoceptor 2/3	Homo sapiens		 89.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322396	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322396&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397615	384225459							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842857	C[C@@H](NC(=O)c1cc(OC2CC3CC2CN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-13-9-29-23(36-13)16-4-15(6-20(7-16)35-21-8-19-5-17(21)12-33(19)3)22(34)32-14(2)18-10-30-24(31-11-18)25(26,27)28/h4,6-7,9-11,14,17,19,21H,5,8,12H2,1-3H3,(H,32,34)/t14-,17?,19?,21?/m1/s1	BQHHMEMNTIGDMM-LXOQGKBISA-N	320042	3-{[2-methyl-2-azabicyclo[2.2.1]hept-5-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 209::US10202369, Example 209::US10472354, Example 209	P2X purinoceptor 2/3	Homo sapiens		 1470							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320042	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320042&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397807	384223318							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842859	C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-13-28-23(35-14)17-10-16(11-19(12-17)34-18-6-8-32(3)9-7-18)22(33)29-15(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,10-13,15,18H,6-9H2,1-3H3,(H,29,33)/t15-/m1/s1	HKVPHDDZBSOGJS-OAHLLOKOSA-N	320043	3-[(1- methylpiperidin- 4-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 210::US10202369, Example 210::US10472354, Example 210	P2X purinoceptor 2/3	Homo sapiens		 1012							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320043	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320043&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397346	384223319							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842861	C[C@@H](NC(=O)c1cc(OC2CN(C)C2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H22F3N5O2S/c1-12-9-26-21(33-12)15-6-14(7-16(8-15)32-17-10-30(3)11-17)20(31)27-13(2)18-4-5-19(29-28-18)22(23,24)25/h4-9,13,17H,10-11H2,1-3H3,(H,27,31)/t13-/m1/s1	IRYKBWGBPIOTOU-CYBMUJFWSA-N	320044	3-[(1- methylazetidin- 3-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl} benzamide::US10174016, Example 211::US10202369, Example 211::US10472354, Example 211	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320044	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320044&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397301	384223320							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842863	C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F4N5O2S/c1-13-9-29-22(36-13)16-6-15(7-18(8-16)35-20-4-5-33(3)12-19(20)25)21(34)32-14(2)17-10-30-23(31-11-17)24(26,27)28/h6-11,14,19-20H,4-5,12H2,1-3H3,(H,32,34)/t14-,19?,20?/m1/s1	XFFHESNTQMKRAI-WPUWVODUSA-N	320045	3-[(3-fluoro-1- methylpiperidin-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a single unknown isomer::US10174016, Example 212::US10202369, Example 212::US10472354, Example 212	P2X purinoceptor 2/3	Homo sapiens		 46.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320045	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320045&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397317	384223321							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842865	C[C@@H](NC(=O)c1cc(OCC2(CC2)N(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)34-13-23(5-6-23)32(3)4)20(33)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,5-6,13H2,1-4H3,(H,31,33)/t15-/m1/s1	GWFQILAPUSJPLG-OAHLLOKOSA-N	320046	3-{[1- (dimethylamino) cyclopropyl] methoxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 213::US10202369, Example 213::US10472354, Example 213	P2X purinoceptor 2/3	Homo sapiens		 81.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320046	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320046&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397636	384223322							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842867	C[C@@H](NC(=O)c1cc(OC2CC3(C2)CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O2S/c1-14-9-29-22(36-14)17-4-16(5-19(6-17)35-20-7-24(8-20)12-33(3)13-24)21(34)32-15(2)18-10-30-23(31-11-18)25(26,27)28/h4-6,9-11,15,20H,7-8,12-13H2,1-3H3,(H,32,34)/t15-/m1/s1	HKONVGJPBICXCZ-OAHLLOKOSA-N	320047	3-[(2-methyl-2- azaspiro [3.3]hept- 6-yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 214::US10202369, Example 214::US10472354, Example 214	P2X purinoceptor 2/3	Homo sapiens		 3392							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320047	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320047&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397792	384223323							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842869	C[C@@H](NC(=O)c1cc(OC2CCN(C)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-11-28-22(35-14)17-8-16(9-20(10-17)34-19-4-6-32(3)7-5-19)21(33)31-15(2)18-12-29-23(30-13-18)24(25,26)27/h8-13,15,19H,4-7H2,1-3H3,(H,31,33)/t15-/m1/s1	BKNIRTNEYAOJDL-OAHLLOKOSA-N	319972	3-[(1-Methylpiperidin-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 139::US10202369, Example 139::US10472354, Example 215	P2X purinoceptor 2/3	Homo sapiens		 992							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319972&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397521	384223252							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842871	C[C@@H](NC(=O)c1cc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22+/m1/s1	BLUSEIUVKSVVTE-DZUANBCISA-N	320049	3-{[(3-endo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 216::US10202369, Example 216::US10472354, Example 216	P2X purinoceptor 2/3	Homo sapiens		 928							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320049	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320049&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397314	384223325							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842873	C[C@@H](NC(=O)c1cc(O[C@H]2C[C@@H]3CC[C@H](C2)N3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O2S/c1-14-11-30-24(37-14)17-6-16(7-21(8-17)36-22-9-19-4-5-20(10-22)34(19)3)23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29/h6-8,11-13,15,19-20,22H,4-5,9-10H2,1-3H3,(H,33,35)/t15-,19-,20+,22-/m1/s1	BLUSEIUVKSVVTE-BWKKGPAXSA-N	320050	3-{[(3-exo)-8- methyl-8- azabicyclo[3.2.1] oct-3-yl]oxy}- 5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 217::US10202369, Example 217::US10472354, Example 217	P2X purinoceptor 2/3	Homo sapiens		 1750							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320050	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320050&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397314	384223326							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842875	C[C@@H](NC(=O)c1cc(O[C@@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21-,22-/m1/s1	FEZSJTOXTJNSGQ-WWGKXEARSA-N	320051	3-{[(4aS,7R, 7aR)-4- methyloctahydro- cyclopenta [b][1,4] oxazin-7-yl] oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 218::US10202369, Example 218::US10472354, Example 218	P2X purinoceptor 2/3	Homo sapiens		 281							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320051	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320051&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397834	384223327							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842877	C[C@@H](NC(=O)c1cc(O[C@H]2CC[C@H]3[C@H]2OCCN3C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-11-30-24(38-14)17-8-16(23(35)33-15(2)18-12-31-25(32-13-18)26(27,28)29)9-19(10-17)37-21-5-4-20-22(21)36-7-6-34(20)3/h8-13,15,20-22H,4-7H2,1-3H3,(H,33,35)/t15-,20+,21+,22-/m1/s1	FEZSJTOXTJNSGQ-NSEXGNSCSA-N	320052	3-{[(4aS,7S, 7aR)-4- methylocta- hydro- cyclopenta[b] [1,4]oxazin- 7-yl]oxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 219::US10202369, Example 219::US10472354, Example 219	P2X purinoceptor 2/3	Homo sapiens		 199							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320052&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397597	384223328							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842879	C[C@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m0/s1	DNVWWBHMIGZIMX-FUKCDUGKSA-N	322410	US10183937, Example 221::US10202369, Example 221::US10472354, Example 220	P2X purinoceptor 2/3	Homo sapiens		 2502							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322410	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322410&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375409	384225472							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842881	C[C@@H](NC(=O)c1cc(OC2CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-14-10-28-22(35-14)17-7-16(8-20(9-17)34-19-5-4-6-32(3)13-19)21(33)31-15(2)18-11-29-23(30-12-18)24(25,26)27/h7-12,15,19H,4-6,13H2,1-3H3,(H,31,33)/t15-,19?/m1/s1	DNVWWBHMIGZIMX-NYRJJRHWSA-N	322409	3-[(1-methylpiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 220::US10202369, Example 220::US10472354, Example 221	P2X purinoceptor 2/3	Homo sapiens		 1358							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322409	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322409&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397678	384225471							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842883	C[C@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m0/s1	ALJCLRFXPKVCLC-KLOIUYPJSA-N	322412	US10183937, Example 223::US10202369, Example 223::US10472354, Example 222	P2X purinoceptor 2/3	Homo sapiens		 108							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322412	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322412&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375410	384225474							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842885	C[C@@H](NC(=O)c1cc(OC2CCN(C)C(C2)C(F)(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-13-10-32-22(39-13)16-6-15(21(37)35-14(2)17-11-33-23(34-12-17)25(29,30)31)7-19(8-16)38-18-4-5-36(3)20(9-18)24(26,27)28/h6-8,10-12,14,18,20H,4-5,9H2,1-3H3,(H,35,37)/t14-,18?,20?/m1/s1	ALJCLRFXPKVCLC-FHTBDLFWSA-N	322411	3-(5-methyl-1,3-thiazol-2-yl)-5-{[1-methyl-2-(trifluoromethyl)piperidin-4-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10183937, Example 222::US10202369, Example 222::US10472354, Example 223	P2X purinoceptor 2/3	Homo sapiens		 109							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322411	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322411&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397819	384225473							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842887	CC(C)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C26H30F3N5O2S/c1-15(2)34-9-7-20(8-10-34)36-21-12-18(11-19(13-21)25-30-14-16(3)37-25)24(35)31-17(4)22-5-6-23(33-32-22)26(27,28)29/h5-6,11-15,17,20H,7-10H2,1-4H3,(H,31,35)/t17-/m1/s1	KRNISEGUXIGIEE-QGZVFWFLSA-N	320057	3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)piperidin-4-yl]oxy}-N-{(1R)-1-[6-(trifluoromethyl)pyridazin-3-yl]ethyl}benzamide::US10174016, Example 224::US10202369, Example 224::US10472354, Example 224	P2X purinoceptor 2/3	Homo sapiens		 569							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320057	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320057&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397429	384223331							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842889	CC(C)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H28F3N5O2S/c1-14(2)33-6-5-20(13-33)35-21-8-17(7-18(9-21)23-29-10-15(3)36-23)22(34)32-16(4)19-11-30-24(31-12-19)25(26,27)28/h7-12,14,16,20H,5-6,13H2,1-4H3,(H,32,34)/t16-,20+/m1/s1	AIBFTYSUMUVEOU-UZLBHIALSA-N	320058	3-(5-methyl- 1,3-thiazol- 2-yl)-5- {[(3S)-1- (propan-2- yl)pyrrolidin- 3-yl]oxy}-N- {(1R)-1- [2-(trifluoro- methyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 225::US10202369, Example 225::US10472354, Example 225	P2X purinoceptor 2/3	Homo sapiens		 1145							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320058	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320058&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397786	384223332							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842891	COC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O4S/c1-14-11-29-22(38-14)17-8-16(9-20(10-17)37-19-4-6-33(7-5-19)24(35)36-3)21(34)32-15(2)18-12-30-23(31-13-18)25(26,27)28/h8-13,15,19H,4-7H2,1-3H3,(H,32,34)/t15-/m1/s1	XKGQQPBORAHPPR-OAHLLOKOSA-N	320059	Methyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 226::US10202369, Example 226::US10472354, Example 226	P2X purinoceptor 2/3	Homo sapiens		 59.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320059	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320059&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397135	384223333							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842893	CCOC(=O)N1CCC(CC1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O4S/c1-4-37-25(36)34-7-5-20(6-8-34)38-21-10-17(9-18(11-21)23-30-12-15(2)39-23)22(35)33-16(3)19-13-31-24(32-14-19)26(27,28)29/h9-14,16,20H,4-8H2,1-3H3,(H,33,35)/t16-/m1/s1	VLNWCOYPKWPZPZ-MRXNPFEDSA-N	320060	Ethyl 4-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]piperidine-1-carboxylate::US10174016, Example 227::US10202369, Example 227::US10472354, Example 227	P2X purinoceptor 2/3	Homo sapiens		 161							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320060	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320060&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397225	384223334							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842895	CCOC(=O)N1CC[C@@H](C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F3N5O4S/c1-4-36-24(35)33-6-5-19(13-33)37-20-8-16(7-17(9-20)22-29-10-14(2)38-22)21(34)32-15(3)18-11-30-23(31-12-18)25(26,27)28/h7-12,15,19H,4-6,13H2,1-3H3,(H,32,34)/t15-,19+/m1/s1	ZKABVOKJBCLEBM-BEFAXECRSA-N	320061	Ethyl (3S)-3-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]pyrrolidine-1-carboxylate::US10174016, Example 228::US10202369, Example 228::US10472354, Example 228	P2X purinoceptor 2/3	Homo sapiens		 54.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320061	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320061&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338446	384223335							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842897	CC(C)N1CC(C1)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O2S/c1-13(2)32-11-20(12-32)34-19-6-16(5-17(7-19)22-28-8-14(3)35-22)21(33)31-15(4)18-9-29-23(30-10-18)24(25,26)27/h5-10,13,15,20H,11-12H2,1-4H3,(H,31,33)/t15-/m1/s1	ZGCTZBYNIOVVEC-OAHLLOKOSA-N	320062	3-(5-Methyl-1,3-thiazol-2-yl)-5-{[1-(propan-2-yl)azetidin-3-yl]oxy}-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 229::US10202369, Example 229::US10472354, Example 229	P2X purinoceptor 2/3	Homo sapiens		 2276							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320062	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320062&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397633	384223336							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842899	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m0/s1	LMHZXBDHIYABCN-HSBZDZAISA-N	322420	US10183937, Example 231::US10202369, Example 231::US10472354, Example 230	P2X purinoceptor 2/3	Homo sapiens		 209							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=322420	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=322420&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138375411	384225482							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842901	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-10-26-21(33-11)16-7-15(8-17(9-16)32-14(4)13(3)30)20(31)27-12(2)18-5-6-19(29-28-18)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,27,31)/t12-,13?,14?/m1/s1	LMHZXBDHIYABCN-IYXRBSQSSA-N	320016	Trans Isomer 1; 3- {[3-hydroxybutan- 2-yl]oxy}-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 183::US10202369, Example 230::US10472354, Example 231	P2X purinoceptor 2/3	Homo sapiens		 706							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320016	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320016&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397175	384223296							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842903	C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O4S2/c1-13-10-27-21(35-13)16-7-15(8-19(9-16)34-18-3-5-36(32,33)6-4-18)20(31)30-14(2)17-11-28-22(29-12-17)23(24,25)26/h7-12,14,18H,3-6H2,1-2H3,(H,30,31)/t14-/m1/s1	JTWSIDWRGZSZAA-CQSZACIVSA-N	320065	3-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 232::US10202369, Example 232::US10472354, Example 232	P2X purinoceptor 2/3	Homo sapiens		 759							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320065	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320065&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397851	384223339							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842905	C[C@@H](NC(=O)c1cc(OC2CCS(=O)(=O)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C24H24F3N3O4S2/c1-14-12-29-23(35-14)18-9-17(10-20(11-18)34-19-5-7-36(32,33)8-6-19)22(31)30-15(2)16-3-4-21(28-13-16)24(25,26)27/h3-4,9-13,15,19H,5-8H2,1-2H3,(H,30,31)/t15-/m1/s1	BRFDVYQZWOBZCT-OAHLLOKOSA-N	320066	3-[(1,1- dioxidotetrahydro- 2H-thiopyran-4- yl)oxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3-yl]ethyl} benzamide::US10174016, Example 233::US10202369, Example 233::US10472354, Example 233	P2X purinoceptor 2/3	Homo sapiens		 753							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320066	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320066&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397139	384223340							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842907	CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-13-27-24(32-21)18-9-17(10-20(11-18)31-19-5-7-30-8-6-19)23(29)28-16(3)22-14-25-15(2)12-26-22/h9-14,16,19H,4-8H2,1-3H3,(H,28,29)/t16-/m1/s1	DYONOLZVTXITOM-MRXNPFEDSA-N	320067	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 234::US10202369, Example 234::US10472354, Example 234	P2X purinoceptor 2/3	Homo sapiens		 152							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320067	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320067&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397540	384223341							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842909	CCc1cnc(s1)-c1cc(OC2CCOCC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-3-21-14-25-23(31-21)17-10-16(11-20(12-17)30-19-6-8-29-9-7-19)22(28)24-13-18-5-4-15(2)26-27-18/h4-5,10-12,14,19H,3,6-9,13H2,1-2H3,(H,24,28)	BZFPOECMUNEZDH-UHFFFAOYSA-N	320068	3-(5-ethyl-1,3- thiazol-2-yl)-N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 235::US10202369, Example 235::US10472354, Example 235	P2X purinoceptor 2/3	Homo sapiens		 70.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320068	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320068&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397197	384223342							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842911	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-13-28-23(14-27-16)17(2)30-25(31)19-10-20(26-29-15-24(34-26)18-4-3-5-18)12-22(11-19)33-21-6-8-32-9-7-21/h10-15,17-18,21H,3-9H2,1-2H3,(H,30,31)/t17-/m1/s1	QOZNFPLCSPWJRX-QGZVFWFLSA-N	320069	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 236::US10202369, Example 236::US10472354, Example 236	P2X purinoceptor 2/3	Homo sapiens		 1012							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320069	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320069&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397529	384223343							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842913	Cc1ccc(CNC(=O)c2cc(OC3CCOCC3)cc(c2)-c2ncc(s2)C2CCC2)nn1	InChI=1S/C25H28N4O3S/c1-16-5-6-20(29-28-16)14-26-24(30)18-11-19(25-27-15-23(33-25)17-3-2-4-17)13-22(12-18)32-21-7-9-31-10-8-21/h5-6,11-13,15,17,21H,2-4,7-10,14H2,1H3,(H,26,30)	KYDTWNODFNIYNY-UHFFFAOYSA-N	320070	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(6- methylpyridazin-3- yl)methyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 237::US10202369, Example 237::US10472354, Example 237	P2X purinoceptor 2/3	Homo sapiens		 537							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320070	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320070&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397323	384223344							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842915	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(19-12-31-25(32-13-19)26(27,28)29)33-23(34)17-9-18(24-30-14-22(37-24)16-3-2-4-16)11-21(10-17)36-20-5-7-35-8-6-20/h9-16,20H,2-8H2,1H3,(H,33,34)/t15-/m1/s1	KTFAMKPHNDUKLL-OAHLLOKOSA-N	320071	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 238::US10202369, Example 238::US10472354, Example 238	P2X purinoceptor 2/3	Homo sapiens		 397							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320071	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320071&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397176	384223345							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842917	C[C@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m0/s1	JWRPHAGJMIAQMD-HOTGVXAUSA-N	320072	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 239::US10202369, Example 239::US10472354, Example 239	P2X purinoceptor 2/3	Homo sapiens		 2171							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320072	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320072&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397719	384223346							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842919	CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18-/m1/s1	OXXUGGORGDKECE-CRAIPNDOSA-N	320073	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 240::US10202369, Example 249::US10472354, Example 240	P2X purinoceptor 2/3	Homo sapiens		 35.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320073	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320073&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397178	384223347							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842921	CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18-/m1/s1	GGGFDTSSCKHCGY-CRAIPNDOSA-N	320074	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 241::US10202369, Example 241::US10472354, Example 241	P2X purinoceptor 2/3	Homo sapiens		 533							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320074	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320074&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397675	384223348							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842923	CCc1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17-/m1/s1	CPHCWMUXIASQAI-CXAGYDPISA-N	320075	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 242::US10202369, Example 242::US10472354, Example 242	P2X purinoceptor 2/3	Homo sapiens		 22.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320075	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320075&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397732	384223349							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842925	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20-/m1/s1	GBDWWYIZWHGLEN-OXQOHEQNSA-N	320076	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 243::US10202369, Example 243::US10472354, Example 243	P2X purinoceptor 2/3	Homo sapiens		 259							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320076	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320076&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397824	384223350							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842927	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20-/m1/s1	FVGXVLFIHFQXPP-OXQOHEQNSA-N	320077	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 244::US10202369, Example 244::US10472354, Example 244	P2X purinoceptor 2/3	Homo sapiens		 555							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320077	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320077&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397416	384223351							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842929	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19-/m1/s1	IDGMWIXZIVCDCF-AUUYWEPGSA-N	320078	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2-(trifluoromethyl) pyrimidin-5-yl] ethyl}benzamide::US10174016, Example 245::US10202369, Example 245::US10472354, Example 245	P2X purinoceptor 2/3	Homo sapiens		 142							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320078	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320078&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397471	384223352							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842931	CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19-/m1/s1	AZADLHFQZQVHQV-VQIMIIECSA-N	320079	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 246::US10202369, Example 246::US10472354, Example 246	P2X purinoceptor 2/3	Homo sapiens		 982							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320079	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320079&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397745	384223353							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842933	CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19-/m1/s1	ULUQVVVXKLITBV-VQIMIIECSA-N	320080	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 247::US10202369, Example 247::US10472354, Example 247	P2X purinoceptor 2/3	Homo sapiens		 963							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320080	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320080&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397213	384223354							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842935	CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18-/m1/s1	COCLYUAEQYUAPW-RDTXWAMCSA-N	320081	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 248::US10202369, Example 248::US10472354, Example 248	P2X purinoceptor 2/3	Homo sapiens		 273							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320081	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320081&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397577	384223355							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842937	CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C23H26N4O3S/c1-4-20-12-24-23(31-20)17-9-16(10-19(11-17)30-18-7-8-29-13-18)22(28)25-15(3)21-6-5-14(2)26-27-21/h5-6,9-12,15,18H,4,7-8,13H2,1-3H3,(H,25,28)/t15-,18+/m1/s1	OXXUGGORGDKECE-QAPCUYQASA-N	320082	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 249::US10472354, Example 249	P2X purinoceptor 2/3	Homo sapiens		 57.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320082	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320082&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397606	384223356							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842939	CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C23H26N4O3S/c1-4-20-11-26-23(31-20)17-7-16(8-19(9-17)30-18-5-6-29-13-18)22(28)27-15(3)21-12-24-14(2)10-25-21/h7-12,15,18H,4-6,13H2,1-3H3,(H,27,28)/t15-,18+/m1/s1	GGGFDTSSCKHCGY-QAPCUYQASA-N	320083	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 250::US10202369, Example 250::US10472354, Example 250	P2X purinoceptor 2/3	Homo sapiens		 299							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320083	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320083&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397653	384223357							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842941	CCc1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-3-19-11-27-21(34-19)15-6-14(7-18(8-15)33-17-4-5-32-12-17)20(31)30-13(2)16-9-28-22(29-10-16)23(24,25)26/h6-11,13,17H,3-5,12H2,1-2H3,(H,30,31)/t13-,17+/m1/s1	CPHCWMUXIASQAI-DYVFJYSZSA-N	320084	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 251::US10202369, Example 251::US10472354, Example 251	P2X purinoceptor 2/3	Homo sapiens		 38.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320084	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320084&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397624	384223358							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842943	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C25H28N4O3S/c1-15-6-7-22(29-28-15)16(2)27-24(30)18-10-19(12-21(11-18)32-20-8-9-31-14-20)25-26-13-23(33-25)17-4-3-5-17/h6-7,10-13,16-17,20H,3-5,8-9,14H2,1-2H3,(H,27,30)/t16-,20+/m1/s1	GBDWWYIZWHGLEN-UZLBHIALSA-N	320085	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 252::US10202369, Example 252::US10472354, Example 252	P2X purinoceptor 2/3	Homo sapiens		 275							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320085	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320085&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397825	384223359							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842945	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C25H28N4O3S/c1-15-11-27-22(12-26-15)16(2)29-24(30)18-8-19(10-21(9-18)32-20-6-7-31-14-20)25-28-13-23(33-25)17-4-3-5-17/h8-13,16-17,20H,3-7,14H2,1-2H3,(H,29,30)/t16-,20+/m1/s1	FVGXVLFIHFQXPP-UZLBHIALSA-N	320086	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 253::US10202369, Example 253::US10472354, Example 253	P2X purinoceptor 2/3	Homo sapiens		 598							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320086	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320086&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397513	384223360							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842947	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F3N4O3S/c1-14(18-10-30-24(31-11-18)25(26,27)28)32-22(33)16-7-17(9-20(8-16)35-19-5-6-34-13-19)23-29-12-21(36-23)15-3-2-4-15/h7-12,14-15,19H,2-6,13H2,1H3,(H,32,33)/t14-,19+/m1/s1	IDGMWIXZIVCDCF-KUHUBIRLSA-N	320087	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 254::US10202369, Example 254::US10472354, Example 254	P2X purinoceptor 2/3	Homo sapiens		 116							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320087	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320087&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397641	384223361							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842949	CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-14(2)22-12-25-24(32-22)18-9-17(10-20(11-18)31-19-7-8-30-13-19)23(29)26-16(4)21-6-5-15(3)27-28-21/h5-6,9-12,14,16,19H,7-8,13H2,1-4H3,(H,26,29)/t16-,19+/m1/s1	AZADLHFQZQVHQV-APWZRJJASA-N	320088	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 255::US10202369, Example 255::US10472354, Example 255	P2X purinoceptor 2/3	Homo sapiens		 449							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320088	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320088&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397188	384223362							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842951	CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-14(2)22-12-27-24(32-22)18-7-17(8-20(9-18)31-19-5-6-30-13-19)23(29)28-16(4)21-11-25-15(3)10-26-21/h7-12,14,16,19H,5-6,13H2,1-4H3,(H,28,29)/t16-,19+/m1/s1	ULUQVVVXKLITBV-APWZRJJASA-N	320089	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 256::US10202369, Example 256::US10472354, Example 256	P2X purinoceptor 2/3	Homo sapiens		 1494							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320089	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320089&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397239	384223363							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842953	CC(C)c1cnc(s1)-c1cc(O[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-22(35-20)16-6-15(7-19(8-16)34-18-4-5-33-12-18)21(32)31-14(3)17-9-29-23(30-10-17)24(25,26)27/h6-11,13-14,18H,4-5,12H2,1-3H3,(H,31,32)/t14-,18+/m1/s1	COCLYUAEQYUAPW-KDOFPFPSSA-N	320090	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 257::US10202369, Example 257::US10472354, Example 257	P2X purinoceptor 2/3	Homo sapiens		 324							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320090	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320090&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397534	384223364							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842955	CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17-/m1/s1	CPQUPRVXRIYFHX-IAGOWNOFSA-N	320091	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 258::US10202369, Example 258::US10472354, Example 282	P2X purinoceptor 2/3	Homo sapiens		 38.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320091	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320091&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397177	384223365							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842957	CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17-/m1/s1	PZFOCXJBZDWRSU-IAGOWNOFSA-N	320092	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 259::US10202369, Example 259::US10472354, Example 283	P2X purinoceptor 2/3	Homo sapiens		 102							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320092	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320092&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397564	384223366							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842959	CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15-/m1/s1	VOKPPDDBRIDGES-HUUCEWRRSA-N	320093	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 260::US10202369, Example 260::US10472354, Example 260	P2X purinoceptor 2/3	Homo sapiens		 14.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320093	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320093&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397266	384223367							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842961	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18-/m1/s1	KRMAXJMLJAVOGJ-QZTJIDSGSA-N	320094	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 261::US10202369, Example 261::US10472354, Example 261	P2X purinoceptor 2/3	Homo sapiens		 317							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320094	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320094&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397842	384223368							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842963	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18-/m1/s1	ZBRXLMDGZXDHGV-QZTJIDSGSA-N	320095	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 262::US10202369, Example 262::US10472354, Example 262	P2X purinoceptor 2/3	Homo sapiens		 383							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320095	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320095&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397383	384223369							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842965	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16-/m1/s1	JWRPHAGJMIAQMD-HZPDHXFCSA-N	320096	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 263::US10202369, Example 263::US10472354, Example 263	P2X purinoceptor 2/3	Homo sapiens		 170							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320096	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320096&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397122	384223370							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842967	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18-/m1/s1	HVLSFPXITWENER-QZTJIDSGSA-N	320097	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 264::US10202369, Example 264::US10472354, Example 264	P2X purinoceptor 2/3	Homo sapiens		 530							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320097	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320097&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397620	384223371							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842969	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18-/m1/s1	MWBSFWZECXCRJX-QZTJIDSGSA-N	320098	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 265::US10202369, Example 265::US10472354, Example 265	P2X purinoceptor 2/3	Homo sapiens		 696							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320098	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320098&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397233	384223372							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842971	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16-/m1/s1	JZRSBKDBMGCFDH-HZPDHXFCSA-N	320099	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 266::US10202369, Example 266::US10472354, Example 266	P2X purinoceptor 2/3	Homo sapiens		 367							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320099	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320099&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397337	384223373							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842973	CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17+/m1/s1	CPQUPRVXRIYFHX-SJORKVTESA-N	320109	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 276::US10472354, Example 276	P2X purinoceptor 2/3	Homo sapiens		 173							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320109&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397609	384223383							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842975	CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17+/m1/s1	PZFOCXJBZDWRSU-SJORKVTESA-N	320110	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 277::US10472354, Example 277	P2X purinoceptor 2/3	Homo sapiens		 392							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320110&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397468	384223384							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842977	CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15+/m1/s1	VOKPPDDBRIDGES-CABCVRRESA-N	320111	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 278::US10472354, Example 278	P2X purinoceptor 2/3	Homo sapiens		 35.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320111&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397387	384223385							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842979	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-6-7-23(30-29-16)17(2)28-25(31)20-10-21(26-27-13-24(34-26)19-4-3-5-19)12-22(11-20)33-15-18-8-9-32-14-18/h6-7,10-13,17-19H,3-5,8-9,14-15H2,1-2H3,(H,28,31)/t17-,18+/m1/s1	KRMAXJMLJAVOGJ-MSOLQXFVSA-N	319968	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(6-methylpyridazin-3-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 135::US10202369, Example 135::US10472354, Example 270	P2X purinoceptor 2/3	Homo sapiens		 100.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319968&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397422	384223248							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842981	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-11-28-23(12-27-16)17(2)30-25(31)20-8-21(26-29-13-24(34-26)19-4-3-5-19)10-22(9-20)33-15-18-6-7-32-14-18/h8-13,17-19H,3-7,14-15H2,1-2H3,(H,30,31)/t17-,18+/m1/s1	ZBRXLMDGZXDHGV-MSOLQXFVSA-N	319954	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-N-[(1R)-1-(5-methylpyrazin-2-yl)ethyl]-5-[(3S)-tetrahydrofuran-3-ylmethoxy]benzamide::US10174016, Example 121::US10202369, Example 121::US10472354, Example 271	P2X purinoceptor 2/3	Homo sapiens		 230							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319954&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397486	384223234							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842983	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(20-10-31-25(32-11-20)26(27,28)29)33-23(34)18-7-19(24-30-12-22(37-24)17-3-2-4-17)9-21(8-18)36-14-16-5-6-35-13-16/h7-12,15-17H,2-6,13-14H2,1H3,(H,33,34)/t15-,16+/m1/s1	JWRPHAGJMIAQMD-CVEARBPZSA-N	319956	3-(5-Cyclobutyl-1,3-thiazol-2-yl)-5-[(3S)-tetrahydrofuran-3-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 123::US10202369, Example 123::US10472354, Example 272	P2X purinoceptor 2/3	Homo sapiens		 128							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319956&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397161	384223236							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842985	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18+/m1/s1	HVLSFPXITWENER-MSOLQXFVSA-N	320112	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 279::US10472354, Example 279	P2X purinoceptor 2/3	Homo sapiens		 254							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320112	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320112&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397672	384223386							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842987	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18+/m1/s1	MWBSFWZECXCRJX-MSOLQXFVSA-N	320113	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 280::US10472354, Example 280	P2X purinoceptor 2/3	Homo sapiens		 873							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320113&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397160	384223387							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842989	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16+/m1/s1	JZRSBKDBMGCFDH-CVEARBPZSA-N	320114	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 281::US10472354, Example 281	P2X purinoceptor 2/3	Homo sapiens		 191							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320114	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320114&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397335	384223388							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842991	CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17+/m1/s1	CPQUPRVXRIYFHX-SJORKVTESA-N	320109	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 276::US10472354, Example 276	P2X purinoceptor 2/3	Homo sapiens		 76.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320109	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320109&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397609	384223383							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842993	CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17+/m1/s1	PZFOCXJBZDWRSU-SJORKVTESA-N	320110	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 277::US10472354, Example 277	P2X purinoceptor 2/3	Homo sapiens		 96.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320110	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320110&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397468	384223384							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842995	CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-11-28-22(35-20)17-6-16(7-19(8-17)34-13-15-4-5-33-12-15)21(32)31-14(2)18-9-29-23(30-10-18)24(25,26)27/h6-11,14-15H,3-5,12-13H2,1-2H3,(H,31,32)/t14-,15+/m1/s1	VOKPPDDBRIDGES-CABCVRRESA-N	320111	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 278::US10472354, Example 278	P2X purinoceptor 2/3	Homo sapiens		 23.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320111	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320111&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397387	384223385							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842997	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C25H30N4O3S/c1-15(2)23-12-26-25(33-23)20-9-19(10-21(11-20)32-14-18-7-8-31-13-18)24(30)27-17(4)22-6-5-16(3)28-29-22/h5-6,9-12,15,17-18H,7-8,13-14H2,1-4H3,(H,27,30)/t17-,18+/m1/s1	HVLSFPXITWENER-MSOLQXFVSA-N	320112	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 279::US10472354, Example 279	P2X purinoceptor 2/3	Homo sapiens		 956							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320112	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320112&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397672	384223386							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
842999	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C25H30N4O3S/c1-15(2)23-12-28-25(33-23)20-7-19(8-21(9-20)32-14-18-5-6-31-13-18)24(30)29-17(4)22-11-26-16(3)10-27-22/h7-12,15,17-18H,5-6,13-14H2,1-4H3,(H,29,30)/t17-,18+/m1/s1	MWBSFWZECXCRJX-MSOLQXFVSA-N	320113	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 280::US10472354, Example 280	P2X purinoceptor 2/3	Homo sapiens		 682							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320113	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320113&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397160	384223387							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843001	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-23(36-21)18-6-17(7-20(8-18)35-13-16-4-5-34-12-16)22(33)32-15(3)19-9-30-24(31-10-19)25(26,27)28/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,32,33)/t15-,16+/m1/s1	JZRSBKDBMGCFDH-CVEARBPZSA-N	320114	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 281::US10472354, Example 281	P2X purinoceptor 2/3	Homo sapiens		 198							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320114	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320114&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397335	384223388							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843003	CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C24H28N4O3S/c1-4-21-12-25-24(32-21)19-9-18(10-20(11-19)31-14-17-7-8-30-13-17)23(29)26-16(3)22-6-5-15(2)27-28-22/h5-6,9-12,16-17H,4,7-8,13-14H2,1-3H3,(H,26,29)/t16-,17-/m1/s1	CPQUPRVXRIYFHX-IAGOWNOFSA-N	320091	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 258::US10202369, Example 258::US10472354, Example 282	P2X purinoceptor 2/3	Homo sapiens		 209							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320091	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320091&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397177	384223365							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843005	CCc1cnc(s1)-c1cc(OC[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C24H28N4O3S/c1-4-21-11-27-24(32-21)19-7-18(8-20(9-19)31-14-17-5-6-30-13-17)23(29)28-16(3)22-12-25-15(2)10-26-22/h7-12,16-17H,4-6,13-14H2,1-3H3,(H,28,29)/t16-,17-/m1/s1	PZFOCXJBZDWRSU-IAGOWNOFSA-N	320092	3-(5-ethyl-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- ylmethoxy] benzamide::US10174016, Example 259::US10202369, Example 259::US10472354, Example 283	P2X purinoceptor 2/3	Homo sapiens		 379							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320092	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320092&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397564	384223366							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843007	CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-20-12-28-22(35-20)16-7-15(8-19(9-16)34-13-18-5-4-6-33-18)21(32)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h7-12,14,18H,3-6,13H2,1-2H3,(H,31,32)/t14-,18+/m1/s1	IDFXYIYQWCENGA-KDOFPFPSSA-N	320117	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 284::US10202369, Example 284::US10472354, Example 284	P2X purinoceptor 2/3	Homo sapiens		 57.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320117	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320117&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397623	384223391							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843009	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(C)nn1	InChI=1S/C26H30N4O3S/c1-16-8-9-23(30-29-16)17(2)28-25(31)19-11-20(26-27-14-24(34-26)18-5-3-6-18)13-22(12-19)33-15-21-7-4-10-32-21/h8-9,11-14,17-18,21H,3-7,10,15H2,1-2H3,(H,28,31)/t17-,21+/m1/s1	NLLVDMMXBRFWGS-UTKZUKDTSA-N	320118	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 285::US10202369, Example 285::US10472354, Example 285	P2X purinoceptor 2/3	Homo sapiens		 760							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320118	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320118&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397163	384223392							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843011	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(C)cn1	InChI=1S/C26H30N4O3S/c1-16-12-28-23(13-27-16)17(2)30-25(31)19-9-20(26-29-14-24(34-26)18-5-3-6-18)11-22(10-19)33-15-21-7-4-8-32-21/h9-14,17-18,21H,3-8,15H2,1-2H3,(H,30,31)/t17-,21+/m1/s1	BHRXSWOPMLFOCG-UTKZUKDTSA-N	320119	3-(5-cyclobutyl- 1,3-thiazol-2-yl)- N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 286::US10202369, Example 286::US10472354, Example 286	P2X purinoceptor 2/3	Homo sapiens		 1234							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320119	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320119&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397754	384223393							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843013	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(19-11-31-25(32-12-19)26(27,28)29)33-23(34)17-8-18(24-30-13-22(37-24)16-4-2-5-16)10-21(9-17)36-14-20-6-3-7-35-20/h8-13,15-16,20H,2-7,14H2,1H3,(H,33,34)/t15-,20+/m1/s1	ZERBIURYMMOJBU-QRWLVFNGSA-N	320120	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 287::US10202369, Example 287::US10472354, Example 287	P2X purinoceptor 2/3	Homo sapiens		 275							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320120	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320120&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397159	384223394							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843015	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(C)nn1	InChI=1S/C25H30N4O3S/c1-15(2)23-13-26-25(33-23)19-10-18(11-21(12-19)32-14-20-6-5-9-31-20)24(30)27-17(4)22-8-7-16(3)28-29-22/h7-8,10-13,15,17,20H,5-6,9,14H2,1-4H3,(H,27,30)/t17-,20+/m1/s1	UAMKMSQRQBQFJK-XLIONFOSSA-N	320121	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy] benzamide::US10174016, Example 288::US10202369, Example 288::US10472354, Example 288	P2X purinoceptor 2/3	Homo sapiens		 1314							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320121	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320121&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397738	384223395							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843017	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(C)cn1	InChI=1S/C25H30N4O3S/c1-15(2)23-13-28-25(33-23)19-8-18(9-21(10-19)32-14-20-6-5-7-31-20)24(30)29-17(4)22-12-26-16(3)11-27-22/h8-13,15,17,20H,5-7,14H2,1-4H3,(H,29,30)/t17-,20+/m1/s1	CNKRLRNKYMMPAE-XLIONFOSSA-N	320122	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-[5- (propan-2-yl)-1,3- thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]benzamide::US10174016, Example 289::US10202369, Example 289::US10472354, Example 289	P2X purinoceptor 2/3	Homo sapiens		 1768							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320122	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320122&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397419	384223396							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843019	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-23(36-21)17-7-16(8-20(9-17)35-13-19-5-4-6-34-19)22(33)32-15(3)18-10-30-24(31-11-18)25(26,27)28/h7-12,14-15,19H,4-6,13H2,1-3H3,(H,32,33)/t15-,19+/m1/s1	KTCCKJLURHRITN-BEFAXECRSA-N	320123	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 290::US10472354, Example 290	P2X purinoceptor 2/3	Homo sapiens		 368							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320123	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320123&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397222	384223397							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843021	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F3N4O3S/c1-12-8-26-20(33-12)15-5-14(6-18(7-15)32-17-3-4-31-11-17)19(30)29-13(2)16-9-27-21(28-10-16)22(23,24)25/h5-10,13,17H,3-4,11H2,1-2H3,(H,29,30)/t13-,17-/m1/s1	GTQPEQGDLVSFJO-CXAGYDPISA-N	319844	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(3R)-tetrahydrofuran-3-yloxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 11::US10202369, Example 11::US10472354, Example 291	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319844	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319844&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397587	384223124							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843023	CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-19-12-28-23(35-19)16-9-15(10-18(11-16)34-13-17-5-4-8-33-17)22(32)29-14(2)20-6-7-21(31-30-20)24(25,26)27/h6-7,9-12,14,17H,3-5,8,13H2,1-2H3,(H,29,32)/t14-,17+/m1/s1	JBKILHBMFZDIIA-PBHICJAKSA-N	320135	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 302::US10202369, Example 302::US10472354, Example 302	P2X purinoceptor 2/3	Homo sapiens		 52.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320135&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397753	384223409							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843025	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18+/m1/s1	QOJBRGRPZKZVKC-QAPCUYQASA-N	320134	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 301::US10472354, Example 301	P2X purinoceptor 2/3	Homo sapiens		 1155							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320134&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397464	384223408							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843027	CC(C)c1cnc(s1)-c1cc(O[C@@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-13(2)20-11-28-23(35-20)16-8-15(9-18(10-16)34-17-6-7-33-12-17)22(32)29-14(3)19-4-5-21(31-30-19)24(25,26)27/h4-5,8-11,13-14,17H,6-7,12H2,1-3H3,(H,29,32)/t14-,17-/m1/s1	ALCUBFBGIYQDIY-RHSMWYFYSA-N	320127	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 294::US10202369, Example 294::US10472354, Example 294	P2X purinoceptor 2/3	Homo sapiens		 1060							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320127	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320127&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397844	384223401							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843029	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H25F3N4O3S/c1-14(20-5-6-22(32-31-20)25(26,27)28)30-23(33)16-9-17(11-19(10-16)35-18-7-8-34-13-18)24-29-12-21(36-24)15-3-2-4-15/h5-6,9-12,14-15,18H,2-4,7-8,13H2,1H3,(H,30,33)/t14-,18+/m1/s1	LCHSLMNVJPMESH-KDOFPFPSSA-N	320128	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 295::US10202369, Example 295::US10472354, Example 295	P2X purinoceptor 2/3	Homo sapiens		 557							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320128	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320128&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397441	384223402							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843031	CCc1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-19-11-28-23(35-19)17-8-16(9-18(10-17)34-13-15-6-7-33-12-15)22(32)29-14(2)20-4-5-21(31-30-20)24(25,26)27/h4-5,8-11,14-15H,3,6-7,12-13H2,1-2H3,(H,29,32)/t14-,15+/m1/s1	PGRAVNCJCWWOPT-CABCVRRESA-N	320129	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 296::US10202369, Example 296::US10472354, Example 296	P2X purinoceptor 2/3	Homo sapiens		 133							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320129	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320129&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397487	384223403							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843033	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCOC2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(21-5-6-23(33-32-21)26(27,28)29)31-24(34)18-9-19(25-30-12-22(37-25)17-3-2-4-17)11-20(10-18)36-14-16-7-8-35-13-16/h5-6,9-12,15-17H,2-4,7-8,13-14H2,1H3,(H,31,34)/t15-,16-/m1/s1	BURFLVDKSSJHQL-HZPDHXFCSA-N	320130	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 297::US10202369, Example 300::US10472354, Example 297	P2X purinoceptor 2/3	Homo sapiens		 933							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320130	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320130&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397174	384223404							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843035	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCOC2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-11-29-24(36-21)18-8-17(9-19(10-18)35-13-16-6-7-34-12-16)23(33)30-15(3)20-4-5-22(32-31-20)25(26,27)28/h4-5,8-11,14-16H,6-7,12-13H2,1-3H3,(H,30,33)/t15-,16+/m1/s1	ZWFOSAQPAKMJAC-CVEARBPZSA-N	320131	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 298::US10202369, Example 299::US10472354, Example 298	P2X purinoceptor 2/3	Homo sapiens		 781							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320131	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320131&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397407	384223405							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843037	CC(C)c1cnc(s1)-c1cc(OC[C@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18-/m1/s1	QOJBRGRPZKZVKC-CRAIPNDOSA-N	320132	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2R)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 299::US10472354, Example 299	P2X purinoceptor 2/3	Homo sapiens		 575							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320132	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320132&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397251	384223406							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843039	C[C@@H](NC(=O)c1cc(OC[C@@H]2CCCO2)cc(c1)-c1ncc(s1)C1CCC1)c1ccc(nn1)C(F)(F)F	InChI=1S/C26H27F3N4O3S/c1-15(21-7-8-23(33-32-21)26(27,28)29)31-24(34)17-10-18(25-30-13-22(37-25)16-4-2-5-16)12-20(11-17)36-14-19-6-3-9-35-19/h7-8,10-13,15-16,19H,2-6,9,14H2,1H3,(H,31,34)/t15-,19+/m1/s1	BFQOMUOMPPUOAS-BEFAXECRSA-N	320133	3-(5-cyclobutyl- 1,3-thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 300::US10472354, Example 300	P2X purinoceptor 2/3	Homo sapiens		 820							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320133	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320133&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397755	384223407							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843041	CC(C)c1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-14(2)21-12-29-24(36-21)17-9-16(10-19(11-17)35-13-18-5-4-8-34-18)23(33)30-15(3)20-6-7-22(32-31-20)25(26,27)28/h6-7,9-12,14-15,18H,4-5,8,13H2,1-3H3,(H,30,33)/t15-,18+/m1/s1	QOJBRGRPZKZVKC-QAPCUYQASA-N	320134	3-[5-(propan-2-yl)- 1,3-thiazol-2-yl]-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 301::US10472354, Example 301	P2X purinoceptor 2/3	Homo sapiens		 1714							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320134	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320134&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397464	384223408							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843043	CCc1cnc(s1)-c1cc(OC[C@@H]2CCCO2)cc(c1)C(=O)N[C@H](C)c1ccc(nn1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-3-19-12-28-23(35-19)16-9-15(10-18(11-16)34-13-17-5-4-8-33-17)22(32)29-14(2)20-6-7-21(31-30-20)24(25,26)27/h6-7,9-12,14,17H,3-5,8,13H2,1-2H3,(H,29,32)/t14-,17+/m1/s1	JBKILHBMFZDIIA-PBHICJAKSA-N	320135	3-(5-ethyl-1,3- thiazol-2-yl)-5- [(2S)- tetrahydrofuran-2- ylmethoxy]-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 302::US10202369, Example 302::US10472354, Example 302	P2X purinoceptor 2/3	Homo sapiens		 145							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320135	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320135&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397753	384223409							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843045	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m1/s1	HEBACSHOFHMYBR-OAHLLOKOSA-N	320136	3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 303::US10202369, Example 310::US10472354, Example 303	P2X purinoceptor 2/3	Homo sapiens		 38.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320136	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320136&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397490	384223410							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843047	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m1/s1	LOLIYPRJHUXCPO-OAHLLOKOSA-N	320137	3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}- 5-(5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoroethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 304::US10202369, Example 308::US10472354, Example 304	P2X purinoceptor 2/3	Homo sapiens		 27.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320137	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320137&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397386	384223411							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843049	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C25H29F2N5O2S/c1-15-4-5-22(31-30-15)17(3)29-24(33)18-10-19(25-28-13-16(2)35-25)12-21(11-18)34-20-6-8-32(9-7-20)14-23(26)27/h4-5,10-13,17,20,23H,6-9,14H2,1-3H3,(H,29,33)/t17-/m1/s1	BZVNHOBJGKGQCM-QGZVFWFLSA-N	320138	3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 305::US10202369, Example 305::US10472354, Example 305	P2X purinoceptor 2/3	Homo sapiens		 44.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320138	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320138&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397226	384223412							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843051	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C25H29F2N5O2S/c1-15-11-29-22(13-28-15)17(3)31-24(33)18-8-19(25-30-12-16(2)35-25)10-21(9-18)34-20-4-6-32(7-5-20)14-23(26)27/h8-13,17,20,23H,4-7,14H2,1-3H3,(H,31,33)/t17-/m1/s1	OVUBAZICSOPILB-QGZVFWFLSA-N	320139	3-{[1-(2,2- difluoroethyl) piperidin-4-yl]oxy}-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-(5- methyl-1,3- thiazol-2-yl) benzamide::US10174016, Example 306::US10202369, Example 306::US10472354, Example 306	P2X purinoceptor 2/3	Homo sapiens		 464							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320139	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320139&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397132	384223413							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843053	Cc1cnc(s1)-c1cc(OC2CCN(CC(F)F)CC2)cc(c1)C(=O)NCc1ccc(C)nn1	InChI=1S/C24H27F2N5O2S/c1-15-3-4-19(30-29-15)13-27-23(32)17-9-18(24-28-12-16(2)34-24)11-21(10-17)33-20-5-7-31(8-6-20)14-22(25)26/h3-4,9-12,20,22H,5-8,13-14H2,1-2H3,(H,27,32)	AGOFJROZQVOSRF-UHFFFAOYSA-N	320140	3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(6-methylpyridazin- 3-yl)methyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 307::US10202369, Example 307::US10472354, Example 307	P2X purinoceptor 2/3	Homo sapiens		 103							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320140	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320140&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397369	384223414							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843055	C[C@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H26F5N5O2S/c1-14-10-31-23(38-14)17-7-16(8-20(9-17)37-19-3-5-35(6-4-19)13-21(26)27)22(36)34-15(2)18-11-32-24(33-12-18)25(28,29)30/h7-12,15,19,21H,3-6,13H2,1-2H3,(H,34,36)/t15-/m0/s1	LOLIYPRJHUXCPO-HNNXBMFYSA-N	320141	3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-5-(5- methyl-1,3-thiazol-2- yl)-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 308::US10472354, Example 308	P2X purinoceptor 2/3	Homo sapiens		 2586							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320141	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320141&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397709	384223415							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843057	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C25H29F2N5O2S/c1-15-11-30-25(35-15)19-8-18(24(33)31-16(2)20-12-28-17(3)29-13-20)9-22(10-19)34-21-4-6-32(7-5-21)14-23(26)27/h8-13,16,21,23H,4-7,14H2,1-3H3,(H,31,33)/t16-/m1/s1	XIVLMPYTLPVWPV-MRXNPFEDSA-N	320142	3-{[1-(2,2- difluoroethyl)piperidin- 4-yl]oxy}-N- [(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-5-(5- methyl-1,3-thiazol-2- yl)benzamide::US10174016, Example 309::US10202369, Example 309::US10472354, Example 309	P2X purinoceptor 2/3	Homo sapiens		 70.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320142	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320142&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397638	384223416							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843059	C[C@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-14-10-32-22(39-14)17-7-16(21(37)35-15(2)18-11-33-23(34-12-18)25(29,30)31)8-20(9-17)38-19-3-5-36(6-4-19)13-24(26,27)28/h7-12,15,19H,3-6,13H2,1-2H3,(H,35,37)/t15-/m0/s1	HEBACSHOFHMYBR-HNNXBMFYSA-N	320143	3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1S)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 310::US10472354, Example 310	P2X purinoceptor 2/3	Homo sapiens		 1678							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320143	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320143&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397431	384223417							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843061	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C25H28F3N5O2S/c1-15-4-5-22(32-31-15)17(3)30-23(34)18-10-19(24-29-13-16(2)36-24)12-21(11-18)35-20-6-8-33(9-7-20)14-25(26,27)28/h4-5,10-13,17,20H,6-9,14H2,1-3H3,(H,30,34)/t17-/m1/s1	PEAPNGOBIXQGEJ-QGZVFWFLSA-N	320144	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 311::US10202369, Example 311::US10472354, Example 314	P2X purinoceptor 2/3	Homo sapiens		 35.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320144&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397300	384223418							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843063	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C25H25F6N5O2S/c1-14-12-32-23(39-14)17-9-16(22(37)33-15(2)20-3-4-21(35-34-20)25(29,30)31)10-19(11-17)38-18-5-7-36(8-6-18)13-24(26,27)28/h3-4,9-12,15,18H,5-8,13H2,1-2H3,(H,33,37)/t15-/m1/s1	AZRJUXHXOIFVSM-OAHLLOKOSA-N	320145	3-(5-methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy}-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 312::US10202369, Example 312::US10472354, Example 312	P2X purinoceptor 2/3	Homo sapiens		 83.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320145	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320145&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397364	384223419							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843065	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)cn1	InChI=1S/C25H28F3N5O2S/c1-15-11-30-22(13-29-15)17(3)32-23(34)18-8-19(24-31-12-16(2)36-24)10-21(9-18)35-20-4-6-33(7-5-20)14-25(26,27)28/h8-13,17,20H,4-7,14H2,1-3H3,(H,32,34)/t17-/m1/s1	VOYLEHBGAUIAGN-QGZVFWFLSA-N	320146	N-[(1R)-1-(5- methylpyrazin-2- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4- yl]oxy}benzamide::US10174016, Example 313::US10202369, Example 313::US10472354, Example 313	P2X purinoceptor 2/3	Homo sapiens		 200							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320146	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320146&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397805	384223420							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843067	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1ccc(C)nn1	InChI=1S/C25H28F3N5O2S/c1-15-4-5-22(32-31-15)17(3)30-23(34)18-10-19(24-29-13-16(2)36-24)12-21(11-18)35-20-6-8-33(9-7-20)14-25(26,27)28/h4-5,10-13,17,20H,6-9,14H2,1-3H3,(H,30,34)/t17-/m1/s1	PEAPNGOBIXQGEJ-QGZVFWFLSA-N	320144	N-[(1R)-1-(6- methylpyridazin-3- yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 311::US10202369, Example 311::US10472354, Example 314	P2X purinoceptor 2/3	Homo sapiens		 192							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320144	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320144&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397300	384223418							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843069	C[C@@H](NC(=O)c1cc(OC2CCN(CC(F)(F)F)CC2)cc(c1)-c1ncc(C)s1)c1cnc(C)nc1	InChI=1S/C25H28F3N5O2S/c1-15-11-31-24(36-15)19-8-18(23(34)32-16(2)20-12-29-17(3)30-13-20)9-22(10-19)35-21-4-6-33(7-5-21)14-25(26,27)28/h8-13,16,21H,4-7,14H2,1-3H3,(H,32,34)/t16-/m1/s1	CJWKMIQNKLHRQL-MRXNPFEDSA-N	320148	N-[(1R)-1-(2- methylpyrimidin- 5-yl)ethyl]-3-(5- methyl-1,3- thiazol-2-yl)-5-{[1- (2,2,2- trifluoroethyl) piperidin-4-yl]oxy} benzamide::US10174016, Example 315::US10202369, Example 315::US10472354, Example 315	P2X purinoceptor 2/3	Homo sapiens		 160							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320148	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320148&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397608	384223422							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843071	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1	InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)16-7-17(22-24-10-20(23)31-22)9-18(8-16)30-12-15-5-6-29-11-15/h3-4,7-10,14-15H,5-6,11-12H2,1-2H3,(H,25,28)/t14-,15+/m1/s1	OPFRVFRBCBSDJR-CABCVRRESA-N	320149	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- ylmethoxy]benzamide::US10174016, Example 316::US10472354, Example 316	P2X purinoceptor 2/3	Homo sapiens		 250							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320149	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320149&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397598	384223423							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843073	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1	InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16-/m1/s1	GKNCXHRLEQHNKW-CZUORRHYSA-N	320150	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 317::US10202369, Example 317::US10472354, Example 317	P2X purinoceptor 2/3	Homo sapiens		 952							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320150	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320150&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397433	384223424							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843075	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14-/m1/s1	WZQSUVWYIQCPQJ-BXUZGUMPSA-N	320151	3-(5-chloro-1,3- thiazol-2-yl)-5- [(3R)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 318::US10202369, Example 318::US10472354, Example 318	P2X purinoceptor 2/3	Homo sapiens		 476							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320151	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320151&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397509	384223425							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843077	C[C@@H](NC(=O)c1cc(O[C@@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1	InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16-/m1/s1	NPEHDEPJRQIOFY-CZUORRHYSA-N	320152	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3R)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 319::US10202369, Example 319::US10472354, Example 319	P2X purinoceptor 2/3	Homo sapiens		 1324							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320152	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320152&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397412	384223426							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843079	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C21H18ClF3N4O3S/c1-11(16-2-3-17(29-28-16)21(23,24)25)27-19(30)12-6-13(20-26-9-18(22)33-20)8-15(7-12)32-14-4-5-31-10-14/h2-3,6-9,11,14H,4-5,10H2,1H3,(H,27,30)/t11-,14+/m1/s1	WZQSUVWYIQCPQJ-RISCZKNCSA-N	320153	3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- yloxy]-N-{(1R)-1- [6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 320::US10202369, Example 320::US10472354, Example 320	P2X purinoceptor 2/3	Homo sapiens		 627							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320153	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320153&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397157	384223427							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843081	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1	InChI=1S/C21H21ClN4O3S/c1-12-8-24-18(9-23-12)13(2)26-20(27)14-5-15(21-25-10-19(22)30-21)7-17(6-14)29-16-3-4-28-11-16/h5-10,13,16H,3-4,11H2,1-2H3,(H,26,27)/t13-,16+/m1/s1	NPEHDEPJRQIOFY-CJNGLKHVSA-N	320154	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 321::US10202369, Example 321::US10472354, Example 321	P2X purinoceptor 2/3	Homo sapiens		 1447							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320154	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320154&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397403	384223428							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843083	C[C@@H](NC(=O)c1cc(O[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1	InChI=1S/C21H21ClN4O3S/c1-12-3-4-18(26-25-12)13(2)24-20(27)14-7-15(21-23-10-19(22)30-21)9-17(8-14)29-16-5-6-28-11-16/h3-4,7-10,13,16H,5-6,11H2,1-2H3,(H,24,27)/t13-,16+/m1/s1	GKNCXHRLEQHNKW-CJNGLKHVSA-N	320155	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5-[(3S)- tetrahydrofuran-3- yloxy]benzamide::US10174016, Example 322::US10202369, Example 322::US10472354, Example 322	P2X purinoceptor 2/3	Homo sapiens		 498							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320155	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320155&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397765	384223429							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843085	C[C@@H](NC(=O)c1cc(OC[C@H]2CCOC2)cc(c1)-c1ncc(Cl)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H20ClF3N4O3S/c1-12(16-7-28-21(29-8-16)22(24,25)26)30-19(31)14-4-15(20-27-9-18(23)34-20)6-17(5-14)33-11-13-2-3-32-10-13/h4-9,12-13H,2-3,10-11H2,1H3,(H,30,31)/t12-,13+/m1/s1	SQNSHDCXZQFUAQ-OLZOCXBDSA-N	320156	3-(5-chloro-1,3- thiazol-2-yl)-5- [(3S)- tetrahydrofuran-3- ylmethoxy]-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 323::US10202369, Example 323::US10472354, Example 323	P2X purinoceptor 2/3	Homo sapiens		 411							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320156	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320156&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397761	384223430							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843087	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1cnc(C)cn1	InChI=1S/C22H23ClN4O3S/c1-13-10-25-19(11-24-13)14(2)27-21(28)15-7-16(22-26-12-20(23)31-22)9-18(8-15)30-17-3-5-29-6-4-17/h7-12,14,17H,3-6H2,1-2H3,(H,27,28)/t14-/m1/s1	LHUVAVZJRUVQTK-CQSZACIVSA-N	320157	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(5- methylpyrazin-2- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 324::US10202369, Example 324::US10472354, Example 324	P2X purinoceptor 2/3	Homo sapiens		 552							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320157	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320157&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397374	384223431							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843089	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(C)nn1	InChI=1S/C22H23ClN4O3S/c1-13-3-4-19(27-26-13)14(2)25-21(28)15-9-16(22-24-12-20(23)31-22)11-18(10-15)30-17-5-7-29-8-6-17/h3-4,9-12,14,17H,5-8H2,1-2H3,(H,25,28)/t14-/m1/s1	WDEIMZWFSWTCLU-CQSZACIVSA-N	320158	3-(5-chloro-1,3- thiazol-2-yl)-N- [(1R)-1-(6- methylpyridazin-3- yl)ethyl]-5- (tetrahydro-2H- pyran-4- yloxy)benzamide::US10174016, Example 325::US10202369, Example 325::US10472354, Example 325	P2X purinoceptor 2/3	Homo sapiens		 235							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320158	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320158&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397325	384223432							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843091	C[C@@H](NC(=O)c1cc(OC2CCOCC2)cc(c1)-c1ncc(Cl)s1)c1ccc(nn1)C(F)(F)F	InChI=1S/C22H20ClF3N4O3S/c1-12(17-2-3-18(30-29-17)22(24,25)26)28-20(31)13-8-14(21-27-11-19(23)34-21)10-16(9-13)33-15-4-6-32-7-5-15/h2-3,8-12,15H,4-7H2,1H3,(H,28,31)/t12-/m1/s1	LBZPSHGDCXIMLR-GFCCVEGCSA-N	320159	3-(5-chloro-1,3- thiazol-2-yl)-5- (tetrahydro-2H- pyran-4-yloxy)-N- {(1R)-1-[6- (trifluoromethyl) pyridazin-3- yl]ethyl}benzamide::US10174016, Example 326::US10202369, Example 326::US10472354, Example 326	P2X purinoceptor 2/3	Homo sapiens		 378							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320159	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320159&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397539	384223433							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843093	C[C@@H](NC(=O)c1cc(OCC2(C)COC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H23F3N4O3S/c1-13-7-27-20(34-13)16-4-15(5-18(6-16)33-12-22(3)10-32-11-22)19(31)30-14(2)17-8-28-21(29-9-17)23(24,25)26/h4-9,14H,10-12H2,1-3H3,(H,30,31)/t14-/m1/s1	JVDZTZBJXQINIP-CQSZACIVSA-N	320160	3-[(3- methyloxetan-3- yl)methoxy]-5-(5- methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 327::US10202369, Example 327::US10472354, Example 327	P2X purinoceptor 2/3	Homo sapiens		 239							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320160	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320160&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397492	384223434							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843095	C[C@@H](NC(=O)c1cc(OCC(C)(C)O)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-12-8-26-19(33-12)15-5-14(6-17(7-15)32-11-21(3,4)31)18(30)29-13(2)16-9-27-20(28-10-16)22(23,24)25/h5-10,13,31H,11H2,1-4H3,(H,29,30)/t13-/m1/s1	CJANIGLDVDYTLU-CYBMUJFWSA-N	320161	3-(2-hydroxy-2- methylpropoxy)-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5-yl]ethyl} benzamide::US10174016, Example 328::US10472354, Example 328	P2X purinoceptor 2/3	Homo sapiens		 274							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320161	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320161&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397727	384223435							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843097	C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1	LFYNTNZWPQXJEM-NKTHEXPSSA-N	320162	3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332	P2X purinoceptor 2/3	Homo sapiens		 120							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397698	384223436							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843099	C[C@@H](NC(=O)c1cc(OC[C@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23+/m1/s1	LFYNTNZWPQXJEM-CMJOXMDJSA-N	320164	US10174016, Example 331::US10472354, Example 333	P2X purinoceptor 2/3	Homo sapiens		 170							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320164&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374910	384223438							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843101	C[C@@H](NC(=O)c1cc(OC[C@@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23-/m1/s1	LFYNTNZWPQXJEM-IQMFZBJNSA-N	320163	3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 330::US10472354, Example 334	P2X purinoceptor 2/3	Homo sapiens		 191							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320163&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374909	384223437							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843103	C[C@@H](NC(=O)c1cc(OCC2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23?/m1/s1	LFYNTNZWPQXJEM-NKTHEXPSSA-N	320162	3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 329::US10202369, Example 330::US10472354, Example 332	P2X purinoceptor 2/3	Homo sapiens		 174							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320162	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320162&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397698	384223436							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843105	C[C@@H](NC(=O)c1cc(OC[C@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23+/m1/s1	LFYNTNZWPQXJEM-CMJOXMDJSA-N	320164	US10174016, Example 331::US10472354, Example 333	P2X purinoceptor 2/3	Homo sapiens		 122							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320164	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320164&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374910	384223438							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843107	C[C@@H](NC(=O)c1cc(OC[C@@]2(C)CCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F3N4O3S/c1-14-10-28-21(35-14)17-7-16(8-19(9-17)33-13-23(3)5-4-6-34-23)20(32)31-15(2)18-11-29-22(30-12-18)24(25,26)27/h7-12,15H,4-6,13H2,1-3H3,(H,31,32)/t15-,23-/m1/s1	LFYNTNZWPQXJEM-IQMFZBJNSA-N	320163	3-[(2-methyltetrahydrofuran-2-yl)methoxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 330::US10472354, Example 334	P2X purinoceptor 2/3	Homo sapiens		 132							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320163	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320163&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374909	384223437							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843109	C[C@@H](NC(=O)c1cc(OC2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18?/m1/s1	CGMVCPWOPCCFBE-IKJXHCRLSA-N	320168	3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two diastereoisomers::US10174016, Example 335::US10202369, Example 336::US10472354, Example 335	P2X purinoceptor 2/3	Homo sapiens		 541							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320168	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320168&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397147	384223442							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843111	C[C@@H](NC(=O)c1cc(O[C@@H]2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18-/m1/s1	CGMVCPWOPCCFBE-RDTXWAMCSA-N	320169	3-[(1-methyl-6-oxopiperidin-3-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 336::US10472354, Example 336	P2X purinoceptor 2/3	Homo sapiens		 443							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320169	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320169&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374913	384223443							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843113	C[C@@H](NC(=O)c1cc(O[C@H]2CCC(=O)N(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F3N5O3S/c1-13-9-28-22(36-13)16-6-15(7-19(8-16)35-18-4-5-20(33)32(3)12-18)21(34)31-14(2)17-10-29-23(30-11-17)24(25,26)27/h6-11,14,18H,4-5,12H2,1-3H3,(H,31,34)/t14-,18+/m1/s1	CGMVCPWOPCCFBE-KDOFPFPSSA-N	320170	US10174016, Example 337::US10472354, Example 337	P2X purinoceptor 2/3	Homo sapiens		 257							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320170	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320170&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374914	384223444							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843115	CC(O)C(C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14?/m1/s1	FSGDRFBLPAILDE-IYXRBSQSSA-N	319995	3-{[3-hydroxybutan-2-yl]oxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 162::US10174016, Example 338::US10202369, Example 339::US10472354, Example 338	P2X purinoceptor 2/3	Homo sapiens		 72.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=319995	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=319995&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397269	384223275							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843117	CC(O)[C@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14+/m1/s1	FSGDRFBLPAILDE-YIOYIWSBSA-N	320172	3-[(3-hydroxybutan-2-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 339::US10472354, Example 339	P2X purinoceptor 2/3	Homo sapiens		 251							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320172	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320172&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374915	384223445							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843119	CC(O)[C@@H](C)Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H23F3N4O3S/c1-11-8-26-20(33-11)16-5-15(6-18(7-16)32-14(4)13(3)30)19(31)29-12(2)17-9-27-21(28-10-17)22(23,24)25/h5-10,12-14,30H,1-4H3,(H,29,31)/t12-,13?,14-/m1/s1	FSGDRFBLPAILDE-WYAMFQBQSA-N	320173	US10174016, Example 340::US10472354, Example 340	P2X purinoceptor 2/3	Homo sapiens		 103							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320173	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320173&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374916	384223446							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843121	C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1	UOQSAFNLRPUQCS-DSXPMEPHSA-N	320174	3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343	P2X purinoceptor 2/3	Homo sapiens		 1242							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397140	384223447							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843123	C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1	UOQSAFNLRPUQCS-DSXPMEPHSA-N	320174	3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343	P2X purinoceptor 2/3	Homo sapiens		 1892							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397140	384223447							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843125	C[C@@H](NC(=O)c1cc(OC2C3COCC2CN(C)C3)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C26H28F3N5O3S/c1-14-7-30-24(38-14)17-4-16(23(35)33-15(2)18-8-31-25(32-9-18)26(27,28)29)5-21(6-17)37-22-19-10-34(3)11-20(22)13-36-12-19/h4-9,15,19-20,22H,10-13H2,1-3H3,(H,33,35)/t15-,19?,20?,22?/m1/s1	UOQSAFNLRPUQCS-DSXPMEPHSA-N	320174	3-[(7-methyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a Mixture of Two Stereoisomers::US10174016, Example 341::US10202369, Example 342::US10472354, Example 343	P2X purinoceptor 2/3	Homo sapiens		 10000							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320174	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320174&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397140	384223447							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843127	CC(C)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O3S/c1-15(2)36-11-21-13-38-14-22(12-36)24(21)39-23-6-18(5-19(7-23)26-32-8-16(3)40-26)25(37)35-17(4)20-9-33-27(34-10-20)28(29,30)31/h5-10,15,17,21-22,24H,11-14H2,1-4H3,(H,35,37)/t17-,21?,22?,24?/m1/s1	IQKMSJWJAJKSIQ-CBDSMJNHSA-N	320177	3-[(7-isopropyl-3-oxa-7-azabicyclo[3.3.1]non-9-yl)oxy]-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, as a mixture of two stereoisomers::US10174016, Example 344::US10202369, Example 344::US10472354, Example 344	P2X purinoceptor 2/3	Homo sapiens		 987							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320177	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320177&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397285	384223450							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843129	COC(C)N1CC2COCC(C1)C2Oc1cc(cc(c1)-c1ncc(C)s1)C(=O)N[C@H](C)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O4S/c1-15-8-32-26(41-15)19-5-18(25(37)35-16(2)20-9-33-27(34-10-20)28(29,30)31)6-23(7-19)40-24-21-11-36(17(3)38-4)12-22(24)14-39-13-21/h5-10,16-17,21-22,24H,11-14H2,1-4H3,(H,35,37)/t16-,17?,21?,22?,24?/m1/s1	CFYKAOKHKJAYDP-TYFPZMBFSA-N	420284	US10472354, Example 345::methyl 9-[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoro-methyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]-3-oxa-7-azabicycle[3.3.1]nonane-7-carboxylate, as a Mixture of Two Stereoisomers	P2X purinoceptor 2/3	Homo sapiens		 99.0							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=420284	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=420284&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search											2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843131	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22-/m1/s1	OEKUZTDVCYAZBS-VGOFRKELSA-N	320179	Tert-butyl (2R)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 346::US10202369, Example 346::US10472354, Example 346	P2X purinoceptor 2/3	Homo sapiens		 334							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320179	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320179&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338449	384223452							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843133	C[C@@H](NC(=O)c1cc(OC[C@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19-/m1/s1	HRVUBTPQOQIHTK-AUUYWEPGSA-N	320180	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2R)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 347::US10202369, Example 347::US10472354, Example 347	P2X purinoceptor 2/3	Homo sapiens		 1521							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320180	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320180&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397601	384223453							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843135	C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20-/m1/s1	MROBUJILSMBILX-FOIQADDNSA-N	320181	3-{[(2R)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 348::US10202369, Example 348::US10472354, Example 348	P2X purinoceptor 2/3	Homo sapiens		 760							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320181	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320181&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397607	384223454							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843137	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(CCO2)C(=O)OC(C)(C)C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C28H32F3N5O5S/c1-16-11-32-24(42-16)19-8-18(23(37)35-17(2)20-12-33-25(34-13-20)28(29,30)31)9-21(10-19)40-15-22-14-36(6-7-39-22)26(38)41-27(3,4)5/h8-13,17,22H,6-7,14-15H2,1-5H3,(H,35,37)/t17-,22+/m1/s1	OEKUZTDVCYAZBS-VGSWGCGISA-N	320182	Tert-butyl (2S)-2-{[3-(5-methyl-1,3-thiazol-2-yl)-5-({(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}carbamoyl)phenoxy]methyl}morpholine-4-carboxylate::US10174016, Example 349::US10202369, Example 349::US10472354, Example 349	P2X purinoceptor 2/3	Homo sapiens		 545							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320182	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320182&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			134338450	384223455							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843139	C[C@@H](NC(=O)c1cc(OC[C@@H]2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19+/m1/s1	HRVUBTPQOQIHTK-KUHUBIRLSA-N	320183	3-(5-Methyl-1,3-thiazol-2-yl)-5-[(2S)-morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 350::US10202369, Example 350::US10472354, Example 350	P2X purinoceptor 2/3	Homo sapiens		 1162							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320183	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320183&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397343	384223456							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843141	C[C@@H](NC(=O)c1cc(OC[C@@H]2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20+/m1/s1	MROBUJILSMBILX-QRWLVFNGSA-N	320184	3-{[(2S)-4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 351::US10202369, Example 351::US10472354, Example 351	P2X purinoceptor 2/3	Homo sapiens		 690							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320184	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320184&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397379	384223457							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843143	C[C@@H](NC(=O)c1cc(OCC2CNCCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C23H24F3N5O3S/c1-13-8-28-21(35-13)16-5-15(6-18(7-16)34-12-19-11-27-3-4-33-19)20(32)31-14(2)17-9-29-22(30-10-17)23(24,25)26/h5-10,14,19,27H,3-4,11-12H2,1-2H3,(H,31,32)/t14-,19?/m1/s1	HRVUBTPQOQIHTK-MJTSIZKDSA-N	320185	3-(5-Methyl-1,3-thiazol-2-yl)-5-[morpholin-2-ylmethoxy]-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, Formed as a Mixture of Example 347 (Diastereoisomer 1) and Example 350 (Diastereoisomer 2)::US10174016, Example 352::US10202369, Example 352::US10472354, Example 352	P2X purinoceptor 2/3	Homo sapiens		 1139							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320185	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320185&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397625	384223458							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843145	C[C@@H](NC(=O)c1cc(OCC2CN(C)CCO2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-19(8-17)35-13-20-12-32(3)4-5-34-20)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,20H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,20?/m1/s1	MROBUJILSMBILX-IWPPFLRJSA-N	320186	3-{[4-methylmorpholin-2-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide, formed as a mixture of Example 348 (Diastereoisomer 2) and Example 351 (Diastereoisomer 1)::US10174016, Example 353::US10202369, Example 353::US10472354, Example 353	P2X purinoceptor 2/3	Homo sapiens		 427							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320186	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320186&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397299	384223459							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843147	C[C@@H](NC(=O)c1cc(OC[C@@]2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23-/m1/s1	KEYDTZMORFCFGJ-IQMFZBJNSA-N	320187	3-(Fluoropiperidin-3-yl)methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 354::US10472354, Example 354	P2X purinoceptor 2/3	Homo sapiens		 1034							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320187	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320187&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374918	384223460							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843149	C[C@@H](NC(=O)c1cc(OC[C@]2(F)CCCNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F4N5O2S/c1-14-9-30-21(36-14)17-6-16(7-19(8-17)35-13-23(25)4-3-5-29-12-23)20(34)33-15(2)18-10-31-22(32-11-18)24(26,27)28/h6-11,15,29H,3-5,12-13H2,1-2H3,(H,33,34)/t15-,23+/m1/s1	KEYDTZMORFCFGJ-CMJOXMDJSA-N	320188	US10174016, Example 355::US10472354, Example 355	P2X purinoceptor 2/3	Homo sapiens		 956							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320188	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320188&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374919	384223461							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843151	C[C@@H](NC(=O)c1cc(OC[C@@]2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24-/m1/s1	JEEGJUGZAOELQB-VOIUYBSRSA-N	320189	3-{[3-fluoro-1-methylpiperidin-3-yl]methoxy}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 356::US10472354, Example 356	P2X purinoceptor 2/3	Homo sapiens		 643							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320189	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320189&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374920	384223462							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843153	C[C@@H](NC(=O)c1cc(OC[C@]2(F)CCCN(C)C2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C25H27F4N5O2S/c1-15-10-30-22(37-15)18-7-17(8-20(9-18)36-14-24(26)5-4-6-34(3)13-24)21(35)33-16(2)19-11-31-23(32-12-19)25(27,28)29/h7-12,16H,4-6,13-14H2,1-3H3,(H,33,35)/t16-,24+/m1/s1	JEEGJUGZAOELQB-GYCJOSAFSA-N	320190	US10174016, Example 357::US10472354, Example 357	P2X purinoceptor 2/3	Homo sapiens		 310							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320190	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320190&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			138374921	384223463							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843155	C[C@@H](NC(=O)c1cc(OCC2(F)CNC2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C22H21F4N5O2S/c1-12-6-28-19(34-12)15-3-14(4-17(5-15)33-11-21(23)9-27-10-21)18(32)31-13(2)16-7-29-20(30-8-16)22(24,25)26/h3-8,13,27H,9-11H2,1-2H3,(H,31,32)/t13-/m1/s1	BCJGFEUMNVQMPR-CYBMUJFWSA-N	320191	3-[(3- fluoroazetidin- 3-yl)methoxy]- 5-(5-methyl- 1,3-thiazol-2- yl)-N-{(1R)-1- [2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide::US10174016, Example 358::US10202369, Example 358::US10472354, Example 358	P2X purinoceptor 2/3	Homo sapiens		 1441							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320191	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320191&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397395	384223464							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843157	C[C@@H](NC(=O)c1cc(OCC2CNCCC2(F)F)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H24F5N5O2S/c1-13-8-31-21(37-13)16-5-15(6-19(7-16)36-12-18-11-30-4-3-23(18,25)26)20(35)34-14(2)17-9-32-22(33-10-17)24(27,28)29/h5-10,14,18,30H,3-4,11-12H2,1-2H3,(H,34,35)/t14-,18?/m1/s1	GMFUIUUSPXQCGC-IKJXHCRLSA-N	320192	3-{[4,4- difluoropiperidin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)- N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of 2 diastereoisomers::US10174016, Example 359::US10202369, Example 359::US10472354, Example 359	P2X purinoceptor 2/3	Homo sapiens		 200							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320192	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320192&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397568	384223465							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843159	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19-/m1/s1	QQIYVSYWBHUFSE-DNVCBOLYSA-N	320193	3-{[(3R)-4-methylmorpholin-3-yl]methoxyl}-5-(5-methyl-1,3-thiazol-2-yl)-N-{(1R)-1-[2-(trifluoromethyl)pyrimidin-5-yl]ethyl}benzamide::US10174016, Example 360::US10202369, Example 360::US10472354, Example 360	P2X purinoceptor 2/3	Homo sapiens		 455							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320193	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320193&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397664	384223466							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843161	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20+/m1/s1	VDLXIDIXMUFWTI-UZLBHIALSA-N	320194	3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 361::US10202369, Example 361::US10472354, Example 361	P2X purinoceptor 2/3	Homo sapiens		 1254							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320194	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320194&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397445	384223467							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843163	C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H26F3N5O3S/c1-14-9-28-22(36-14)17-6-16(7-20(8-17)35-13-19-12-34-5-4-32(19)3)21(33)31-15(2)18-10-29-23(30-11-18)24(25,26)27/h6-11,15,19H,4-5,12-13H2,1-3H3,(H,31,33)/t15-,19+/m1/s1	QQIYVSYWBHUFSE-BEFAXECRSA-N	320195	3-{[(3S)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyridin-5- yl]ethyl} benzamide::US10174016, Example 362::US10202369, Example 362::US10472354, Example 362	P2X purinoceptor 2/3	Homo sapiens		 1014							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320195	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320195&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397415	384223468							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843165	C[C@@H](NC(=O)c1cc(OC[C@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H27F3N4O3S/c1-15-11-30-24(36-15)19-8-18(9-21(10-19)35-14-20-13-34-7-6-32(20)3)23(33)31-16(2)17-4-5-22(29-12-17)25(26,27)28/h4-5,8-12,16,20H,6-7,13-14H2,1-3H3,(H,31,33)/t16-,20-/m1/s1	VDLXIDIXMUFWTI-OXQOHEQNSA-N	320196	3-{[(3R)-4- methylmorpholin- 3- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide::US10174016, Example 363::US10472354, Example 363	P2X purinoceptor 2/3	Homo sapiens		 717							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320196	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320196&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397368	384223469							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843167	C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F	InChI=1S/C24H25F4N5O2S/c1-13-8-29-22(36-13)16-4-15(5-20(6-16)35-12-19-7-18(25)11-33(19)3)21(34)32-14(2)17-9-30-23(31-10-17)24(26,27)28/h4-6,8-10,14,18-19H,7,11-12H2,1-3H3,(H,32,34)/t14-,18?,19?/m1/s1	UCQIVXMFKURDDU-FTXHTYHOSA-N	320197	3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 364::US10202369, Example 364::US10472354, Example 364	P2X purinoceptor 2/3	Homo sapiens		 943							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320197&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397240	384223470							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
843169	C[C@@H](NC(=O)c1cc(OCC2CC(F)CN2C)cc(c1)-c1ncc(C)s1)c1ccc(nc1)C(F)(F)F	InChI=1S/C25H26F4N4O2S/c1-14-10-31-24(36-14)18-6-17(7-21(8-18)35-13-20-9-19(26)12-33(20)3)23(34)32-15(2)16-4-5-22(30-11-16)25(27,28)29/h4-8,10-11,15,19-20H,9,12-13H2,1-3H3,(H,32,34)/t15-,19?,20?/m1/s1	XNRRWTQJTXNPEU-APMMTJHUSA-N	320198	3-{[4-fluoro-1- methylpyrrolidin- 2- yl]methoxy}-5- (5-methyl-1,3- thiazol-2-yl)-N- {(1R)-1-[6- (trifluoromethyl) pyridin-3- yl]ethyl} benzamide, as a mixture of stereoisomers::US10174016, Example 365::US10202369, Example 365::US10472354, Example 365	P2X purinoceptor 2/3	Homo sapiens		 1049							US Patent		10.7270/Q2KD2197		aid1803961	US10472354	Davenport, AJ; Brauer, N; Fischer, OM; Rotgeri, A; Rottmann, A; Neagoe, I; Nagel, J; Godinho-Coelho, A; Klar, J	Bayer Aktiengesellschaft	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=320198	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=320198&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			121397581	384223471							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51315785	OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@@H]1CCCc2ccccc12	InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m1/s1	VQGBOYBIENNKMI-GDLZYMKVSA-N	86480	A-317344	P2X purinoceptor 2/3	Homo sapiens	 1100								ChEMBL	10.1016/j.bmcl.2016.07.009	10.7270/Q26W9FJD	27423478			Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A	Gedeon Richter Plc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86480&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			9894155	136352529						ZINC01912736	2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51315801	OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@@H]1CCCc2ccccc12	InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m1/s1	VQGBOYBIENNKMI-GDLZYMKVSA-N	86480	A-317344	P2X purinoceptor 2/3	Homo sapiens	 1100								ChEMBL	10.1016/j.bmcl.2016.07.009	10.7270/Q26W9FJD	27423478			Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A	Gedeon Richter Plc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86480	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86480&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			9894155	136352529						ZINC01912736	2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51315836	OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@H]1CCCc2ccccc12	InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1	VQGBOYBIENNKMI-LJAQVGFWSA-N	86478	A-317491	P2X purinoceptor 2/3	Homo sapiens	 9.0								ChEMBL	10.1016/j.bmcl.2016.07.009	10.7270/Q26W9FJD	27423478			Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A	Gedeon Richter Plc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86478	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86478&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	71C		9829395	136352527				4115		ZINC03990058	2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51315877	OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc1cccc(Oc2ccccc2)c1)[C@H]1CCCc2ccccc12	InChI=1S/C33H27NO8/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41)/t29-/m0/s1	VQGBOYBIENNKMI-LJAQVGFWSA-N	86478	A-317491	P2X purinoceptor 2/3	Homo sapiens	 9.0								ChEMBL	10.1016/j.bmcl.2016.07.009	10.7270/Q26W9FJD	27423478			Szántó, G; Makó, A; Bata, I; Farkas, B; Kolok, S; Vastag, M; Cselenyák, A	Gedeon Richter Plc	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86478	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86478&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	71C		9829395	136352527				4115		ZINC03990058	2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51393313	CC(C)Oc1ccc(Nc2nc(=O)n(CC(C)(C)C(O)=O)c(=O)n2Cc2ccc(Cl)cc2)cc1F	InChI=1S/C24H26ClFN4O5/c1-14(2)35-19-10-9-17(11-18(19)26)27-21-28-22(33)30(13-24(3,4)20(31)32)23(34)29(21)12-15-5-7-16(25)8-6-15/h5-11,14H,12-13H2,1-4H3,(H,31,32)(H,27,28,33)	CAYYASMSWISXDA-UHFFFAOYSA-N	183200	US9150546, I-364::US9688643, I-364::US9718790, I-0364	P2X purinoceptor 2/3	Homo sapiens		 2366							ChEMBL	10.1016/j.bmcl.2021.127833	10.7270/Q2V40ZXF	33540044			Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y	Shionogi & Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=183200	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=183200&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			76821363	313634600							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51393314	CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl	InChI=1S/C23H25ClN4O5/c1-14(2)33-19-9-8-17(12-18(19)24)25-21-26-22(31)27(11-10-20(29)30)23(32)28(21)13-16-6-4-15(3)5-7-16/h4-9,12,14H,10-11,13H2,1-3H3,(H,29,30)(H,25,26,31)	KRHNDEFYSFIWAD-UHFFFAOYSA-N	50563052	CHEMBL4748113	P2X purinoceptor 2/3	Homo sapiens		 2931							ChEMBL	10.1016/j.bmcl.2021.127833	10.7270/Q2V40ZXF	33540044			Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y	Shionogi & Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563052	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563052&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			68020375	461683390							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51393315	COc1cc(C(C)C)c(Oc2cnc(NC(CO)CO)nc2N)cc1I	InChI=1S/C17H23IN4O4/c1-9(2)11-4-14(25-3)12(18)5-13(11)26-15-6-20-17(22-16(15)19)21-10(7-23)8-24/h4-6,9-10,23-24H,7-8H2,1-3H3,(H3,19,20,21,22)	PAYROHWFGZADBR-UHFFFAOYSA-N	50257829	2-(4-amino-5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidin-2-ylamino)propane-1,3-diol::CHEMBL494161::Ro-51	P2X purinoceptor 2/3	Homo sapiens		 45							ChEMBL	10.1016/j.bmcl.2021.127833	10.7270/Q2V40ZXF	33540044			Kai, H; Horiguchi, T; Kameyama, T; Asahi, K; Endoh, T; Jikihara, S; Hasegawa, T; Tanaka, S; Nozu, A; Takeyama, C; Tomari, M; Takahashi, F; Tamura, N; Yagi, S; Itoh, T; Isou, Y	Shionogi & Co., Ltd.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257829	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257829&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			24883277	104108764		CHEMBL494161				ZINC40953233	2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51467789	CNC(=O)c1cc(F)c(-c2nc3cc(C)ccc3n2CC2CCCN(C2)C(=O)OC)c(F)c1	InChI=1S/C24H26F2N4O3/c1-14-6-7-20-19(9-14)28-22(21-17(25)10-16(11-18(21)26)23(31)27-2)30(20)13-15-5-4-8-29(12-15)24(32)33-3/h6-7,9-11,15H,4-5,8,12-13H2,1-3H3,(H,27,31)	NKHHRLBCVCBDBN-UHFFFAOYSA-N	50592268	CHEMBL5207941	P2X purinoceptor 2/3	Homo sapiens		 9740							ChEMBL		10.7270/Q2SX6J56	35644300			Bae, J; Kang, KM; Kim, YC	Gwangju Institute of Science and Technology (GIST)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592268	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592268&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			168295731	482603120							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51467790	COC(=O)N1CCC(Cn2c(Cc3ccc(Cl)cc3)nc3cc(C)ccc23)CC1	InChI=1S/C23H26ClN3O2/c1-16-3-8-21-20(13-16)25-22(14-17-4-6-19(24)7-5-17)27(21)15-18-9-11-26(12-10-18)23(28)29-2/h3-8,13,18H,9-12,14-15H2,1-2H3	UWIVCUPYGZJQHQ-UHFFFAOYSA-N	50592270	CHEMBL5204294	P2X purinoceptor 2/3	Homo sapiens		 8760							ChEMBL		10.7270/Q2SX6J56	35644300			Bae, J; Kang, KM; Kim, YC	Gwangju Institute of Science and Technology (GIST)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592270	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592270&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			168294120	482603122							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51467791	CCC(=O)N1CCC(Cn2c(Cc3ccc(Cl)cc3)nc3cc(C)ccc23)CC1	InChI=1S/C24H28ClN3O/c1-3-24(29)27-12-10-19(11-13-27)16-28-22-9-4-17(2)14-21(22)26-23(28)15-18-5-7-20(25)8-6-18/h4-9,14,19H,3,10-13,15-16H2,1-2H3	KNFOCBIYILAWQH-UHFFFAOYSA-N	50592271	CHEMBL5205988	P2X purinoceptor 2/3	Homo sapiens		 8350							ChEMBL		10.7270/Q2SX6J56	35644300			Bae, J; Kang, KM; Kim, YC	Gwangju Institute of Science and Technology (GIST)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592271	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592271&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			168296227	482603123							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51461815	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]2OC3(O[C@@H]12)C(=CC(C=C3[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O	InChI=1S/C16H17N8O19P3/c17-13-10-14(19-4-18-13)21(5-20-10)15-12-11(7(39-15)3-38-45(34,35)43-46(36,37)42-44(31,32)33)40-16(41-12)8(23(27)28)1-6(22(25)26)2-9(16)24(29)30/h1-2,4-7,11-12,15H,3H2,(H,34,35)(H,36,37)(H2,17,18,19)(H2,31,32,33)/t6?,7-,11-,12-,15-,16?/m1/s1	TXMXHIVKIUHZFM-YKWNPASPSA-N	50540410	CHEMBL337395	P2X purinoceptor 2/3	Homo sapiens		 64							ChEMBL		10.7270/Q2RX9H1T	36150180			Toti, KS; Verma, R; McGonnigle, MJ; Gamiotea Turro, D; Wen, Z; Lewicki, SA; Liang, BT; Jacobson, KA	National Institute of Diabetes and Digestive and Kidney Diseases	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540410	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540410&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			11542191	442141973					C03517		2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473555	COc1ccc(cc1)C(=O)O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1OC(=O)c1ccc(OC)cc1)n1cnc2c(N)ncnc12	InChI=1S/C26H28N5O17P3/c1-41-16-7-3-14(4-8-16)25(32)45-20-18(11-43-50(37,38)48-51(39,40)47-49(34,35)36)44-24(31-13-30-19-22(27)28-12-29-23(19)31)21(20)46-26(33)15-5-9-17(42-2)10-6-15/h3-10,12-13,18,20-21,24H,11H2,1-2H3,(H,37,38)(H,39,40)(H2,27,28,29)(H2,34,35,36)/t18-,20-,21-,24-/m1/s1	RKFOOQRRMNOARS-UMCMBGNQSA-N	50594494	CHEMBL5197509	P2X purinoceptor 2/3	Homo sapiens		<100000							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594494	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594494&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			168284464	482605346							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473556	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1F	InChI=1S/C10H15FN5O12P3/c11-5-7(17)4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17H,1H2,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20)/t4-,5-,7-,10-/m1/s1	CCXCDDWASROAJA-QYYRPYCUSA-N	50594495	CHEMBL4576110	P2X purinoceptor 2/3	Homo sapiens		 5370							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594495	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594495&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			126365	482605347							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473557	N[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c(N)ncnc12	InChI=1S/C10H17N6O12P3/c11-5-7(17)4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17H,1,11H2,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20)/t4-,5-,7-,10-/m1/s1	BPRNAIIYYOQQKN-QYYRPYCUSA-N	50594496	CHEMBL4582937	P2X purinoceptor 2/3	Homo sapiens		 363							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594496	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594496&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			50997601	482605348							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473558	CO[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1cnc2c(N)ncnc12	InChI=1S/C11H18N5O13P3/c1-25-8-7(17)5(2-26-31(21,22)29-32(23,24)28-30(18,19)20)27-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20)	OARVGPYQJRLYFE-UHFFFAOYSA-N	50026197	Adenosine 5'-triphosphate derivative::CHEMBL3142844	P2X purinoceptor 2/3	Homo sapiens		<100000							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026197	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026197&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			3012940	103935931		CHEMBL3142844CHEMBL109409			C03517	ZINC43335443	2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473559	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@@H]1O	InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7+,10-/m1/s1	ZKHQWZAMYRWXGA-UHTZMRCNSA-N	50594497	CHEMBL4441501	P2X purinoceptor 2/3	Homo sapiens		<100000							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594497	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594497&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	HEJ		65128	482605349							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473560	O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(Cl)ncnc12	InChI=1S/C10H14ClN4O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1	WNBYTJKDDLUPCV-KQYNXXCUSA-N	526264	US11185100, TABLE 14.4	P2X purinoceptor 2/3	Homo sapiens		 129							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=526264	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=526264&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			6453225	463789904					C03517		2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473561	O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(S)ncnc12	InChI=1S/C10H15N4O13P3S/c15-6-4(1-24-29(20,21)27-30(22,23)26-28(17,18)19)25-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)31/h2-4,6-7,10,15-16H,1H2,(H,20,21)(H,22,23)(H,11,12,31)(H2,17,18,19)/t4-,6-,7-,10-/m1/s1	GQNRDWAOABGWGP-KQYNXXCUSA-N	50594498	CHEMBL4583478	P2X purinoceptor 2/3	Homo sapiens		 8.3							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594498	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594498&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			3036942	482605350							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473562	CNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O	InChI=1S/C11H18N5O13P3/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(27-11)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-5,7-8,11,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1	LCQWKKZWHQFOAH-IOSLPCCCSA-N	50318030	((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-(methylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyltriphosphate tetraammonium salt::CHEMBL1094109	P2X purinoceptor 2/3	Homo sapiens		 263							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50318030	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50318030&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	N6E		49797718	104152391		CHEMBL1094109			C03517	ZINC49774268	2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473563	CCCCNc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O	InChI=1S/C14H24N5O13P3/c1-2-3-4-15-12-9-13(17-6-16-12)19(7-18-9)14-11(21)10(20)8(30-14)5-29-34(25,26)32-35(27,28)31-33(22,23)24/h6-8,10-11,14,20-21H,2-5H2,1H3,(H,25,26)(H,27,28)(H,15,16,17)(H2,22,23,24)/t8-,10-,11-,14-/m1/s1	LDLJTALPLRVDBD-IDTAVKCVSA-N	50594499	CHEMBL5171786	P2X purinoceptor 2/3	Homo sapiens		 692							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594499	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594499&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			168270465	482605351							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473564	O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(Nc3ccccc3)ncnc12	InChI=1S/C16H20N5O13P3/c22-12-10(6-31-36(27,28)34-37(29,30)33-35(24,25)26)32-16(13(12)23)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h1-5,7-8,10,12-13,16,22-23H,6H2,(H,27,28)(H,29,30)(H,17,18,20)(H2,24,25,26)/t10-,12-,13-,16-/m1/s1	MXSCITZYHDRLLP-XNIJJKJLSA-N	50594500	CHEMBL5202979	P2X purinoceptor 2/3	Homo sapiens		 158							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594500	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594500&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			44755145	482605352							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473565	O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(NCc3ccccc3)ncnc12	InChI=1S/C17H22N5O13P3/c23-13-11(7-32-37(28,29)35-38(30,31)34-36(25,26)27)33-17(14(13)24)22-9-21-12-15(19-8-20-16(12)22)18-6-10-4-2-1-3-5-10/h1-5,8-9,11,13-14,17,23-24H,6-7H2,(H,28,29)(H,30,31)(H,18,19,20)(H2,25,26,27)/t11-,13-,14-,17-/m1/s1	NUUDCFZWGUJXPV-LSCFUAHRSA-N	50594501	CHEMBL5170304	P2X purinoceptor 2/3	Homo sapiens		 2692							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594501	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594501&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			44755036	482605353							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473566	O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c3nccn3cnc12	InChI=1S/C12H16N5O13P3/c18-8-6(3-27-32(23,24)30-33(25,26)29-31(20,21)22)28-12(9(8)19)17-5-14-7-10-13-1-2-16(10)4-15-11(7)17/h1-2,4-6,8-9,12,18-19H,3H2,(H,23,24)(H,25,26)(H2,20,21,22)/t6-,8-,9-,12-/m1/s1	BKQZGVPRPNNNDW-WOUKDFQISA-N	50594502	CHEMBL5200154	P2X purinoceptor 2/3	Homo sapiens		 282							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594502	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594502&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			14130517	482605354							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473567	Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(N=[N+]=[N-])nc12	InChI=1S/C10H15N8O13P3/c11-7-4-8(14-2-13-7)18(10(15-4)16-17-12)9-6(20)5(19)3(29-9)1-28-33(24,25)31-34(26,27)30-32(21,22)23/h2-3,5-6,9,19-20H,1H2,(H,24,25)(H,26,27)(H2,11,13,14)(H2,21,22,23)/t3-,5-,6-,9-/m1/s1	PQISXOFEOCLOCT-UUOKFMHZSA-N	50594503	CHEMBL4567276	P2X purinoceptor 2/3	Homo sapiens		<100000							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594503	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594503&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			2735431	482605355							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473568	O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1c2ncncc2[nH]c1=O			50594504	CHEMBL5170556	P2X purinoceptor 2/3	Homo sapiens		<100000							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594504	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594504&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			168270309	482605356							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473569	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1	InChI=1S/C24H24N5O15P3/c25-20-17-21(27-12-26-20)29(13-28-17)22-19(42-24(31)15-9-5-2-6-10-15)18(41-23(30)14-7-3-1-4-8-14)16(40-22)11-39-46(35,36)44-47(37,38)43-45(32,33)34/h1-10,12-13,16,18-19,22H,11H2,(H,35,36)(H,37,38)(H2,25,26,27)(H2,32,33,34)/t16-,18-,19-,22-/m1/s1	IKEQMDLYPNVQGH-WGQQHEPDSA-N	50594505	CHEMBL5177316	P2X purinoceptor 2/3	Homo sapiens				 1202					ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594505	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594505&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			5311061	482605357							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473570	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c2cccc3ccccc23)[C@H]1OC(=O)c1cccc2ccccc12	InChI=1S/C32H28N5O15P3/c33-28-25-29(35-16-34-28)37(17-36-25)30-27(50-32(39)23-14-6-10-19-8-2-4-12-21(19)23)26(49-31(38)22-13-5-9-18-7-1-3-11-20(18)22)24(48-30)15-47-54(43,44)52-55(45,46)51-53(40,41)42/h1-14,16-17,24,26-27,30H,15H2,(H,43,44)(H,45,46)(H2,33,34,35)(H2,40,41,42)/t24-,26-,27-,30-/m1/s1	PSBROSWEMLTASJ-BQOYKFDPSA-N	50594506	CHEMBL5183218	P2X purinoceptor 2/3	Homo sapiens				<100000					ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594506	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594506&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			168278797	482605358							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473628	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c2ccccc2)[C@H]1OC(=O)c1ccccc1	InChI=1S/C24H24N5O15P3/c25-20-17-21(27-12-26-20)29(13-28-17)22-19(42-24(31)15-9-5-2-6-10-15)18(41-23(30)14-7-3-1-4-8-14)16(40-22)11-39-46(35,36)44-47(37,38)43-45(32,33)34/h1-10,12-13,16,18-19,22H,11H2,(H,35,36)(H,37,38)(H2,25,26,27)(H2,32,33,34)/t16-,18-,19-,22-/m1/s1	IKEQMDLYPNVQGH-WGQQHEPDSA-N	50594505	CHEMBL5177316	P2X purinoceptor 2/3	Homo sapiens		<100000							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594505	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594505&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			5311061	482605357							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473629	COc1ccc(cc1)C(=O)O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1OC(=O)c1ccc(OC)cc1)n1cnc2c(N)ncnc12	InChI=1S/C26H28N5O17P3/c1-41-16-7-3-14(4-8-16)25(32)45-20-18(11-43-50(37,38)48-51(39,40)47-49(34,35)36)44-24(31-13-30-19-22(27)28-12-29-23(19)31)21(20)46-26(33)15-5-9-17(42-2)10-6-15/h3-10,12-13,18,20-21,24H,11H2,1-2H3,(H,37,38)(H,39,40)(H2,27,28,29)(H2,34,35,36)/t18-,20-,21-,24-/m1/s1	RKFOOQRRMNOARS-UMCMBGNQSA-N	50594494	CHEMBL5197509	P2X purinoceptor 2/3	Homo sapiens		<100000							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594494	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594494&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			168284464	482605346							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
51473630	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c2cccc3ccccc23)[C@H]1OC(=O)c1cccc2ccccc12	InChI=1S/C32H28N5O15P3/c33-28-25-29(35-16-34-28)37(17-36-25)30-27(50-32(39)23-14-6-10-19-8-2-4-12-21(19)23)26(49-31(38)22-13-5-9-18-7-1-3-11-20(18)22)24(48-30)15-47-54(43,44)52-55(45,46)51-53(40,41)42/h1-14,16-17,24,26-27,30H,15H2,(H,43,44)(H,45,46)(H2,33,34,35)(H2,40,41,42)/t24-,26-,27-,30-/m1/s1	PSBROSWEMLTASJ-BQOYKFDPSA-N	50594506	CHEMBL5183218	P2X purinoceptor 2/3	Homo sapiens		 11482							ChEMBL		10.7270/Q2XS60DK	35930402			Isaak, A; Dobelmann, C; Füsser, FT; Erlitz, KS; Koch, O; Junker, A	European Institute for Molecular Imaging (EIMI)	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594506	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594506&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			168278797	482605358							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385065	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1N	InChI=1S/C12H14BrN5O/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18)	KVMKNPHEMHTMED-UHFFFAOYSA-N	656869	US11919918, Compound C2	P2X purinoceptor 2/3	Homo sapiens		 249							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656869	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656869&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576033	496175935							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385066	CC(C)c1cnc(Cl)cc1Oc1cnc(N)nc1N	InChI=1S/C12H14ClN5O/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18)	AGSPLJZFKPBSFH-UHFFFAOYSA-N	656870	US11919918, Compound C3	P2X purinoceptor 2/3	Homo sapiens		 341							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656870	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656870&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			146940256	496175936							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385067	COc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C13H17N5O2/c1-7(2)8-5-16-11(19-3)4-9(8)20-10-6-17-13(15)18-12(10)14/h4-7H,1-3H3,(H4,14,15,17,18)	YIFDMDASOQQQCR-UHFFFAOYSA-N	656871	US11919918, Compound C4	P2X purinoceptor 2/3	Homo sapiens		 158							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656871	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656871&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576048	496175937							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385068	CC(C)c1cnc(C)cc1Oc1cnc(N)nc1N	InChI=1S/C13H17N5O/c1-7(2)9-5-16-8(3)4-10(9)19-11-6-17-13(15)18-12(11)14/h4-7H,1-3H3,(H4,14,15,17,18)	WHXGJYHUGMGUEJ-UHFFFAOYSA-N	656878	US11919918, Compound C9	P2X purinoceptor 2/3	Homo sapiens		 379							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656878	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656878&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576027	496175944							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385069	CC(C)c1ncc(Cl)cc1Oc1cnc(N)nc1N	InChI=1S/C12H14ClN5O/c1-6(2)10-8(3-7(13)4-16-10)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18)	GWRKJESGDZRWLP-UHFFFAOYSA-N	656879	US11919918, Compound C10	P2X purinoceptor 2/3	Homo sapiens		 1820							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656879	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656879&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576067	496175945							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385070	CC(C)c1cnc(I)cc1Oc1cnc(N)nc1N	InChI=1S/C12H14IN5O/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18)	LLLJBGAVSRMERV-UHFFFAOYSA-N	656880	US11919918, Compound C12	P2X purinoceptor 2/3	Homo sapiens		 56.7							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656880	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656880&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148366362	496175946							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385071	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)-c1ccccc1	InChI=1S/C18H19N5O/c1-11(2)13-9-21-14(12-6-4-3-5-7-12)8-15(13)24-16-10-22-18(20)23-17(16)19/h3-11H,1-2H3,(H4,19,20,22,23)	OBGPSFYWTMIERK-UHFFFAOYSA-N	656881	5-(5- isopropyl-2- phenylpyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C13	P2X purinoceptor 2/3	Homo sapiens		 599							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656881	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656881&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148732594	496175947							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385072	CCc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C14H19N5O/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h5-8H,4H2,1-3H3,(H4,15,16,18,19)	ZQDHWIRHCQDPAE-UHFFFAOYSA-N	656882	US11919918, Compound C15	P2X purinoceptor 2/3	Homo sapiens		 793							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656882	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656882&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576028	496175948							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385073	CSc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C13H17N5OS/c1-7(2)8-5-16-11(20-3)4-9(8)19-10-6-17-13(15)18-12(10)14/h4-7H,1-3H3,(H4,14,15,17,18)	BXXIYYYYYVIZGF-UHFFFAOYSA-N	656884	US11919918, Compound C20	P2X purinoceptor 2/3	Homo sapiens		 75.7							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656884	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656884&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576038	496175950							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385074	CC(C)c1cnc(N)cc1Oc1cnc(N)nc1N	InChI=1S/C12H16N6O/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H2,13,16)(H4,14,15,17,18)	ODNZBUXEQRISGA-UHFFFAOYSA-N	656885	US11919918, Compound C21	P2X purinoceptor 2/3	Homo sapiens		 200							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656885	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656885&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576065	496175951							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385075	CNc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C13H18N6O/c1-7(2)8-5-17-11(16-3)4-9(8)20-10-6-18-13(15)19-12(10)14/h4-7H,1-3H3,(H,16,17)(H4,14,15,18,19)	PEHVVBHHSDSXRU-UHFFFAOYSA-N	656886	US11919918, Compound C22	P2X purinoceptor 2/3	Homo sapiens		 57.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656886	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656886&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576050	496175952							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385076	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)N(C)C	InChI=1S/C14H20N6O/c1-8(2)9-6-17-12(20(3)4)5-10(9)21-11-7-18-14(16)19-13(11)15/h5-8H,1-4H3,(H4,15,16,18,19)	OAHSCRYMJYQLQT-UHFFFAOYSA-N	656887	US11919918, Compound C23	P2X purinoceptor 2/3	Homo sapiens		 644							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656887	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656887&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576041	496175953							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385077	COc1cc(Oc2cnc(N)nc2N)c(cn1)C1CC1	InChI=1S/C13H15N5O2/c1-19-11-4-9(8(5-16-11)7-2-3-7)20-10-6-17-13(15)18-12(10)14/h4-7H,2-3H2,1H3,(H4,14,15,17,18)	SUVDLCJLJDKSND-UHFFFAOYSA-N	656888	5-((5- cyclopropyl-2- methoxypyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C33	P2X purinoceptor 2/3	Homo sapiens		 262							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656888	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656888&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124170	496175954							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385078	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)-c1ccco1	InChI=1S/C16H17N5O2/c1-9(2)10-7-19-11(12-4-3-5-22-12)6-13(10)23-14-8-20-16(18)21-15(14)17/h3-9H,1-2H3,(H4,17,18,20,21)	MFKZQPIHSOOHCF-UHFFFAOYSA-N	656891	5-((2-(furan-2- yl)-5- isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C39	P2X purinoceptor 2/3	Homo sapiens		 243							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656891	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656891&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148473507	496175957							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385079	CC(C)c1cnc(C=C)cc1Oc1cnc(N)nc1N	InChI=1S/C14H17N5O/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h4-8H,1H2,2-3H3,(H4,15,16,18,19)	KKRLDNGHTZSISE-UHFFFAOYSA-N	656893	5-(5- isopropyl-2- vinylpyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C43	P2X purinoceptor 2/3	Homo sapiens		 180							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656893	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656893&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148214766	496175959							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385080	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C(C)=C	InChI=1S/C15H19N5O/c1-8(2)10-6-18-11(9(3)4)5-12(10)21-13-7-19-15(17)20-14(13)16/h5-8H,3H2,1-2,4H3,(H4,16,17,19,20)	WIROOCGHVUYFNW-UHFFFAOYSA-N	656894	5-(5- isopropyl-2- (prop-1-en-2- yl)pyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C44	P2X purinoceptor 2/3	Homo sapiens		 423							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656894	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656894&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			153194404	496175960							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385081	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C1CC1	InChI=1S/C15H19N5O/c1-8(2)10-6-18-11(9-3-4-9)5-12(10)21-13-7-19-15(17)20-14(13)16/h5-9H,3-4H2,1-2H3,(H4,16,17,19,20)	WVZOUPADCCZQPF-UHFFFAOYSA-N	656896	5-((2- cyclopropyl-5- isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C52	P2X purinoceptor 2/3	Homo sapiens		 589							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656896	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656896&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			153265026	496175962							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385082	CCN(C)c1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C15H22N6O/c1-5-21(4)13-6-11(10(7-18-13)9(2)3)22-12-8-19-15(17)20-14(12)16/h6-9H,5H2,1-4H3,(H4,16,17,19,20)	PUOXAMUKBKHYHP-UHFFFAOYSA-N	656897	5-((2- (ethyl(methyl) amino)-5- isopropylpyridin- 4-yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C61	P2X purinoceptor 2/3	Homo sapiens		 592							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656897	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656897&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148974782	496175963							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385083	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)N(C)C1CC1	InChI=1S/C16H22N6O/c1-9(2)11-7-19-14(22(3)10-4-5-10)6-12(11)23-13-8-20-16(18)21-15(13)17/h6-10H,4-5H2,1-3H3,(H4,17,18,20,21)	OXAANSGVXLISAN-UHFFFAOYSA-N	656898	5-((2- (cyclopropyl (methyl)amino)- 5-isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C65	P2X purinoceptor 2/3	Homo sapiens		 506							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656898	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656898&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148848829	496175964							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385084	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#C	InChI=1S/C14H15N5O/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h1,5-8H,2-3H3,(H4,15,16,18,19)	TZHOVNUCGUXMCS-UHFFFAOYSA-N	656899	US11919918, Compound C66	P2X purinoceptor 2/3	Homo sapiens		 154							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656899	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656899&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576053	496175965							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385085	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCN(C)C	InChI=1S/C16H23BrN6O/c1-10(2)11-8-20-14(17)7-12(11)24-13-9-21-16(18)22-15(13)19-5-6-23(3)4/h7-10H,5-6H2,1-4H3,(H3,18,19,21,22)	NTYGXVZTWUAHKY-UHFFFAOYSA-N	656901	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- (dimethylamino) ethyl)pyrimidine- 2,4-diamine::US11919918, Compound C71	P2X purinoceptor 2/3	Homo sapiens		 67.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656901	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656901&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			151258931	496175967							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385086	CSc1cc(Oc2cnc(N)nc2NCCN(C)C)c(cn1)C(C)C	InChI=1S/C17H26N6OS/c1-11(2)12-9-20-15(25-5)8-13(12)24-14-10-21-17(18)22-16(14)19-6-7-23(3)4/h8-11H,6-7H2,1-5H3,(H3,18,19,21,22)	FECARLDMQZFILK-UHFFFAOYSA-N	656902	US11919918, Compound C72	P2X purinoceptor 2/3	Homo sapiens		 89.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656902	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656902&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			150145142	496175968							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385087	CC(C)c1cnc(Cl)cc1Sc1cnc(N)nc1N	InChI=1S/C12H14ClN5S/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18)	MKNMLTBPGWDXSU-UHFFFAOYSA-N	656903	5-((2-chloro-5- isopropylpyridin- 4- yl)thio)pyrimidine- 2,4-diamine::US11919918, Compound C84	P2X purinoceptor 2/3	Homo sapiens		 742							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656903	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656903&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148500388	496175969							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385088	CC(C)c1cnc(Br)cc1Sc1cnc(N)nc1N	InChI=1S/C12H14BrN5S/c1-6(2)7-4-16-10(13)3-8(7)19-9-5-17-12(15)18-11(9)14/h3-6H,1-2H3,(H4,14,15,17,18)	JQUPJHIEDALLMO-UHFFFAOYSA-N	656904	US11919918, Compound C85	P2X purinoceptor 2/3	Homo sapiens		 205							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656904	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656904&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576051	496175970							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385089	CC(C)c1cnc(cc1Sc1cnc(N)nc1N)C#C	InChI=1S/C14H15N5S/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h1,5-8H,2-3H3,(H4,15,16,18,19)	PVOUUQULJNSJOF-UHFFFAOYSA-N	656905	5-((2-ethynyl- 5-isopropyl- pyrdin-4- yl)thio) pyrimidine- 2,4-diamine::US11919918, Compound C88	P2X purinoceptor 2/3	Homo sapiens		 122							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656905	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656905&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148980196	496175971							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385090	CSc1cc(Sc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C13H17N5S2/c1-7(2)8-5-16-11(19-3)4-9(8)20-10-6-17-13(15)18-12(10)14/h4-7H,1-3H3,(H4,14,15,17,18)	BWFZYZCFPMPZSF-UHFFFAOYSA-N	656906	5-((5- isopropyl2- (methylthio) pyridin-4- yl)thio) pyrimidine- 2,4-diamine::US11919918, Compound C91	P2X purinoceptor 2/3	Homo sapiens		 271							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656906	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656906&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			147163199	496175972							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385091	CC(C)c1cnc(C)cc1Sc1cnc(N)nc1N	InChI=1S/C13H17N5S/c1-7(2)9-5-16-8(3)4-10(9)19-11-6-17-13(15)18-12(11)14/h4-7H,1-3H3,(H4,14,15,17,18)	JOHQHBOLGWWBLV-UHFFFAOYSA-N	656907	5-((5- isopropyl-2- methylpyridin- 4-yl)thio) pyrimidine-2,4- diamine::US11919918, Compound C92	P2X purinoceptor 2/3	Homo sapiens		 222							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656907	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656907&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124180	496175973							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385092	CC(C)c1cnc(C=C)cc1Sc1cnc(N)nc1N	InChI=1S/C14H17N5S/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h4-8H,1H2,2-3H3,(H4,15,16,18,19)	CDEYQQUBKOBYOR-UHFFFAOYSA-N	656908	US11919918, Compound C95	P2X purinoceptor 2/3	Homo sapiens		 163							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656908	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656908&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576068	496175974							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385093	CC(C)c1cnc(Br)cc1Oc1cnc(NC(CO)CO)nc1N	InChI=1S/C15H20BrN5O3/c1-8(2)10-4-18-13(16)3-11(10)24-12-5-19-15(21-14(12)17)20-9(6-22)7-23/h3-5,8-9,22-23H,6-7H2,1-2H3,(H3,17,19,20,21)	OSHJDJRUKMFRDG-UHFFFAOYSA-N	656909	2-((4-amino-5- ((2-bromo-5- isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) propane-1,3-diol::US11919918, Compound C111	P2X purinoceptor 2/3	Homo sapiens		 129							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656909	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656909&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148823744	496175975							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385094	CCSc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C14H19N5OS/c1-4-21-12-5-10(9(6-17-12)8(2)3)20-11-7-18-14(16)19-13(11)15/h5-8H,4H2,1-3H3,(H4,15,16,18,19)	AKEDQYHLXJPQLZ-UHFFFAOYSA-N	656910	5-((2- (ethylthio)-5- isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C117	P2X purinoceptor 2/3	Homo sapiens		 487							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656910	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656910&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124176	496175976							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385095	CCNc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C14H20N6O/c1-4-17-12-5-10(9(6-18-12)8(2)3)21-11-7-19-14(16)20-13(11)15/h5-8H,4H2,1-3H3,(H,17,18)(H4,15,16,19,20)	CRJCWJFKFRPLTC-UHFFFAOYSA-N	656911	5-((2- (ethylamino)- 5-isopropylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C118	P2X purinoceptor 2/3	Homo sapiens		 366							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656911	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656911&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124110	496175977							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385096	CC(C)c1cnc(NC2CC2)cc1Oc1cnc(N)nc1N	InChI=1S/C15H20N6O/c1-8(2)10-6-18-13(20-9-3-4-9)5-11(10)22-12-7-19-15(17)21-14(12)16/h5-9H,3-4H2,1-2H3,(H,18,20)(H4,16,17,19,21)	BOKPYXYHQNMPNH-UHFFFAOYSA-N	656912	5-((2- (cyclopropylamino)- 5-isopropylpyridin- 4-yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C119	P2X purinoceptor 2/3	Homo sapiens		 505							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656912	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656912&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			149807136	496175978							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385097	CCc1cc(Sc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C14H19N5S/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h5-8H,4H2,1-3H3,(H4,15,16,18,19)	NOONYIJXAZILAG-UHFFFAOYSA-N	656916	US11919918, Compound C127	P2X purinoceptor 2/3	Homo sapiens		 234							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656916	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656916&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576039	496175982							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385098	CC(C)c1cnc(cc1Sc1cnc(N)nc1N)[Si](C)(C)C	InChI=1S/C15H23N5SSi/c1-9(2)10-7-18-13(22(3,4)5)6-11(10)21-12-8-19-15(17)20-14(12)16/h6-9H,1-5H3,(H4,16,17,19,20)	FFASROZGQOVOOX-UHFFFAOYSA-N	656918	US11919918, Compound C133	P2X purinoceptor 2/3	Homo sapiens		 770							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656918	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656918&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			171392712	496175984							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385099	CC#Cc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C15H17N5O/c1-4-5-10-6-12(11(7-18-10)9(2)3)21-13-8-19-15(17)20-14(13)16/h6-9H,1-3H3,(H4,16,17,19,20)	FICXDGOQGVTZHX-UHFFFAOYSA-N	656919	5-((5- isopropyl-2- (prop-1-yn-1- yl)pyridin-4- yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C134	P2X purinoceptor 2/3	Homo sapiens		 685							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656919	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656919&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			147504835	496175985							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385100	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccccc1	InChI=1S/C20H19N5O/c1-13(2)16-11-23-15(9-8-14-6-4-3-5-7-14)10-17(16)26-18-12-24-20(22)25-19(18)21/h3-7,10-13H,1-2H3,(H4,21,22,24,25)	FYANIFPIHNQHSL-UHFFFAOYSA-N	656920	5-((5- isopropyl-2- (phenyl- ethynyl)pyridin- 4-yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C135	P2X purinoceptor 2/3	Homo sapiens		 488							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656920	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656920&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			147589652	496175986							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385101	COc1ccc(cc1)C#Cc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)C	InChI=1S/C21H21N5O2/c1-13(2)17-11-24-15(7-4-14-5-8-16(27-3)9-6-14)10-18(17)28-19-12-25-21(23)26-20(19)22/h5-6,8-13H,1-3H3,(H4,22,23,25,26)	LFTNEZMAGHDYFJ-UHFFFAOYSA-N	656921	5-((5- isopropyl-2- ((4- methoxyphenyl) ethynyl)pyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C136	P2X purinoceptor 2/3	Homo sapiens		 416							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656921	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656921&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			150929702	496175987							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385102	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccc(cc1)C#N	InChI=1S/C21H18N6O/c1-13(2)17-11-25-16(8-7-14-3-5-15(10-22)6-4-14)9-18(17)28-19-12-26-21(24)27-20(19)23/h3-6,9,11-13H,1-2H3,(H4,23,24,26,27)	HKUNGVHAVIJXRM-UHFFFAOYSA-N	656922	4-((4-(2,4- diaminopyrimidin- 5-yl)oxy)-5- isopropylpyridin- 2-yl)ethynyl) benzonitrile::US11919918, Compound C137	P2X purinoceptor 2/3	Homo sapiens		 567							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656922	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656922&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124107	496175988							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385103	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#CC1CC1	InChI=1S/C17H19N5O/c1-10(2)13-8-20-12(6-5-11-3-4-11)7-14(13)23-15-9-21-17(19)22-16(15)18/h7-11H,3-4H2,1-2H3,(H4,18,19,21,22)	PVHVQMXMWCXFNA-UHFFFAOYSA-N	656924	5-((2- (cyclo- propylethynyl)-5- isopropylpyrdin- 4-yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C142	P2X purinoceptor 2/3	Homo sapiens		 549							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656924	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656924&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148978754	496175990							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385104	COc1cc(OC)c(C#Cc2cc(Oc3cnc(N)nc3N)c(cn2)C(C)C)c(OC)c1	InChI=1S/C23H25N5O4/c1-13(2)17-11-26-14(8-20(17)32-21-12-27-23(25)28-22(21)24)6-7-16-18(30-4)9-15(29-3)10-19(16)31-5/h8-13H,1-5H3,(H4,24,25,27,28)	VJMUDXGGLHQMCM-UHFFFAOYSA-N	656925	5-((5-isopropyl-2- ((2,4,6- trimethoxyphenyl) ethynyl)pyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C145	P2X purinoceptor 2/3	Homo sapiens		 623							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656925	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656925&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			152142460	496175991							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385105	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccc(cc1)N(C)C	InChI=1S/C22H24N6O/c1-14(2)18-12-25-16(8-5-15-6-9-17(10-7-15)28(3)4)11-19(18)29-20-13-26-22(24)27-21(20)23/h6-7,9-14H,1-4H3,(H4,23,24,26,27)	DKTDGMNQZZWPGF-UHFFFAOYSA-N	656926	5-((2-((4- (dimethylamino) phenyl) ethynyl)-5- isopropylpyridin- 4-yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C148	P2X purinoceptor 2/3	Homo sapiens		 113							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656926	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656926&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			150048271	496175992							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385106	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1cccc2cccnc12	InChI=1S/C23H20N6O/c1-14(2)18-12-27-17(11-19(18)30-20-13-28-23(25)29-22(20)24)9-8-16-6-3-5-15-7-4-10-26-21(15)16/h3-7,10-14H,1-2H3,(H4,24,25,28,29)	GHVNDPJDWUQRFN-UHFFFAOYSA-N	656927	5-((5-isopropyl-2- (quinolin-8- ylethynyl)pyridin- 4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C149	P2X purinoceptor 2/3	Homo sapiens		 266							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656927	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656927&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124114	496175993							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385107	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccccn1	InChI=1S/C19H18N6O/c1-12(2)15-10-23-14(7-6-13-5-3-4-8-22-13)9-16(15)26-17-11-24-19(21)25-18(17)20/h3-5,8-12H,1-2H3,(H4,20,21,24,25)	QBWVEPYAYJVLEC-UHFFFAOYSA-N	656928	5-((5-isopropyl-2- (pyridin-2- ylethynyl)pyridin- 4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C150	P2X purinoceptor 2/3	Homo sapiens		 232							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656928	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656928&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			151558019	496175994							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385108	CC(C)c1cnc(cc1Oc1cnc(N)nc1N)C#Cc1ccncc1	InChI=1S/C19H18N6O/c1-12(2)15-10-23-14(4-3-13-5-7-22-8-6-13)9-16(15)26-17-11-24-19(21)25-18(17)20/h5-12H,1-2H3,(H4,20,21,24,25)	VLXHZXIGOVJXCC-UHFFFAOYSA-N	656929	5-((5-isopropyl-2- (pyridin-4- ylethynyl)pyridin- 4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C151	P2X purinoceptor 2/3	Homo sapiens		 961							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656929	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656929&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124168	496175995							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385109	CC(C)c1cnc(NCC(F)(F)F)cc1Oc1cnc(N)nc1N	InChI=1S/C14H17F3N6O/c1-7(2)8-4-20-11(22-6-14(15,16)17)3-9(8)24-10-5-21-13(19)23-12(10)18/h3-5,7H,6H2,1-2H3,(H,20,22)(H4,18,19,21,23)	BYBDRISYVLDBFK-UHFFFAOYSA-N	656930	5-((5- isopropyl-2- (2,2,2- trifluoroethyl) amino) pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C152	P2X purinoceptor 2/3	Homo sapiens		 375							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656930	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656930&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			147172849	496175996							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385110	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NC(CO)CO	InChI=1S/C15H20BrN5O3/c1-8(2)10-4-18-13(16)3-11(10)24-12-5-19-15(17)21-14(12)20-9(6-22)7-23/h3-5,8-9,22-23H,6-7H2,1-2H3,(H3,17,19,20,21)	JQZGMYVGSHHBDG-UHFFFAOYSA-N	656931	2-((2-amino-5- ((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4- yl)amino) propane-1,3-diol::US11919918, Compound C153	P2X purinoceptor 2/3	Homo sapiens		 96.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656931	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656931&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148109302	496175997							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385111	CCN(C)CCNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C	InChI=1S/C17H25BrN6O/c1-5-24(4)7-6-20-16-14(10-22-17(19)23-16)25-13-8-15(18)21-9-12(13)11(2)3/h8-11H,5-7H2,1-4H3,(H3,19,20,22,23)	UFAGZDFWUPYOKN-UHFFFAOYSA-N	656932	US11919918, Compound C154	P2X purinoceptor 2/3	Homo sapiens		 46.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656932	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656932&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			151992747	496175998							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385112	CC(C)c1cnc(CN)cc1Oc1cnc(N)nc1N	InChI=1S/C13H18N6O/c1-7(2)9-5-17-8(4-14)3-10(9)20-11-6-18-13(16)19-12(11)15/h3,5-7H,4,14H2,1-2H3,(H4,15,16,18,19)	KHKXFAJFCUEAGK-UHFFFAOYSA-N	656934	US11919918, Compound C157	P2X purinoceptor 2/3	Homo sapiens		 978							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656934	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656934&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			142576029	496176000							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385113	COc1cc(Oc2cnc(N)nc2N)c(C=C)cn1	InChI=1S/C12H13N5O2/c1-3-7-5-15-10(18-2)4-8(7)19-9-6-16-12(14)17-11(9)13/h3-6H,1H2,2H3,(H4,13,14,16,17)	KQZCOEOLDXOUFC-UHFFFAOYSA-N	656935	5-((2-methoxy- 5-vinylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C162	P2X purinoceptor 2/3	Homo sapiens		 429							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656935	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656935&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148257471	496176001							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385114	COc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)=C	InChI=1S/C13H15N5O2/c1-7(2)8-5-16-11(19-3)4-9(8)20-10-6-17-13(15)18-12(10)14/h4-6H,1H2,2-3H3,(H4,14,15,17,18)	TYZMBZZLUNQFAR-UHFFFAOYSA-N	656936	5-((2-methoxy- 5-(prop-1-en-2- yl)pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C164::US11919918, Compound C196	P2X purinoceptor 2/3	Homo sapiens		 71.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656936&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			152868778	496176002							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385115	CCc1cnc(OC)cc1Oc1cnc(N)nc1N	InChI=1S/C12H15N5O2/c1-3-7-5-15-10(18-2)4-8(7)19-9-6-16-12(14)17-11(9)13/h4-6H,3H2,1-2H3,(H4,13,14,16,17)	PFELYIBYHFKCBW-UHFFFAOYSA-N	656937	5-((5-ethyl-2- methoxy- pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C165	P2X purinoceptor 2/3	Homo sapiens		 338							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656937	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656937&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148892353	496176003							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385116	CNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C	InChI=1S/C13H16BrN5O/c1-7(2)8-5-17-11(14)4-9(8)20-10-6-18-13(15)19-12(10)16-3/h4-7H,1-3H3,(H3,15,16,18,19)	NSUKKTYUFVSNHM-UHFFFAOYSA-N	656938	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- methyl- pyrimidine- 2,4-diamine::US11919918, Compound C172	P2X purinoceptor 2/3	Homo sapiens		 209							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656938	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656938&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148687494	496176004							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385117	CCNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C	InChI=1S/C14H18BrN5O/c1-4-17-13-11(7-19-14(16)20-13)21-10-5-12(15)18-6-9(10)8(2)3/h5-8H,4H2,1-3H3,(H3,16,17,19,20)	NPEHEUZJNYCFCU-UHFFFAOYSA-N	656939	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- ethylpyrimidine- 2,4-diamine::US11919918, Compound C173	P2X purinoceptor 2/3	Homo sapiens		 259							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656939	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656939&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148668224	496176005							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385118	CC(C)Nc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C	InChI=1S/C15H20BrN5O/c1-8(2)10-6-18-13(16)5-11(10)22-12-7-19-15(17)21-14(12)20-9(3)4/h5-9H,1-4H3,(H3,17,19,20,21)	SKQJDJRXLHWOEY-UHFFFAOYSA-N	656940	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- isopropyl- pyrimidine- 2,4-diamine::US11919918, Compound C174	P2X purinoceptor 2/3	Homo sapiens		 145							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656940	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656940&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			146860970	496176006							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385119	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCO	InChI=1S/C14H18BrN5O2/c1-8(2)9-6-18-12(15)5-10(9)22-11-7-19-14(16)20-13(11)17-3-4-21/h5-8,21H,3-4H2,1-2H3,(H3,16,17,19,20)	JZVHWPXVFWORNA-UHFFFAOYSA-N	656941	2-((2-amino-5- ((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4- yl)amino)ethanol.::US11919918, Compound C175	P2X purinoceptor 2/3	Homo sapiens		 141							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656941	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656941&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148156534	496176007							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385120	COc1cc(Oc2cnc(N)nc2N)c(C)cn1	InChI=1S/C11H13N5O2/c1-6-4-14-9(17-2)3-7(6)18-8-5-15-11(13)16-10(8)12/h3-5H,1-2H3,(H4,12,13,15,16)	ZJGLBNQRURZPSI-UHFFFAOYSA-N	656942	5-((2-methoxy- 5-methylpyridin- 4-yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C176	P2X purinoceptor 2/3	Homo sapiens		 984							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656942	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656942&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			149513268	496176008							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385121	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NC1CC1	InChI=1S/C15H18BrN5O/c1-8(2)10-6-18-13(16)5-11(10)22-12-7-19-15(17)21-14(12)20-9-3-4-9/h5-9H,3-4H2,1-2H3,(H3,17,19,20,21)	GZPLJULLZGHQLS-UHFFFAOYSA-N	656943	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- cyclopropyl- pyrimidine-2,4- diamine::US11919918, Compound C179	P2X purinoceptor 2/3	Homo sapiens		 43.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656943	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656943&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			147737213	496176009							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385122	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NC1CCCCC1	InChI=1S/C18H24BrN5O/c1-11(2)13-9-21-16(19)8-14(13)25-15-10-22-18(20)24-17(15)23-12-6-4-3-5-7-12/h8-12H,3-7H2,1-2H3,(H3,20,22,23,24)	GZUOIWVCCGUPHS-UHFFFAOYSA-N	656944	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- cyclohexyl- pyrimidine-2,4- diamine::US11919918, Compound C180	P2X purinoceptor 2/3	Homo sapiens		 220							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656944	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656944&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			150381337	496176010							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385123	CC(C)CNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C	InChI=1S/C16H22BrN5O/c1-9(2)6-20-15-13(8-21-16(18)22-15)23-12-5-14(17)19-7-11(12)10(3)4/h5,7-10H,6H2,1-4H3,(H3,18,20,21,22)	NFGRNNZHAVSBEF-UHFFFAOYSA-N	656945	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4- isobutyl- pyrimidine- 2,4-diamine::US11919918, Compound C181	P2X purinoceptor 2/3	Homo sapiens		 78.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656945	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656945&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155130483	496176011							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385124	CNc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)=C	InChI=1S/C13H16N6O/c1-7(2)8-5-17-11(16-3)4-9(8)20-10-6-18-13(15)19-12(10)14/h4-6H,1H2,2-3H3,(H,16,17)(H4,14,15,18,19)	BMXZCGUHPQBDFN-UHFFFAOYSA-N	656947	5-((2- (methylamino)-5- (prop-1-en-2- yl)pyridin-4- yl)oxy)pyrimidine- 2,4-diamine::US11919918, Compound C192	P2X purinoceptor 2/3	Homo sapiens		 69.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656947	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656947&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124093	496176013							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385125	CC(C)CNc1nc(N)ncc1Oc1cc(ncc1C(C)C)C1CC1	InChI=1S/C19H27N5O/c1-11(2)8-22-18-17(10-23-19(20)24-18)25-16-7-15(13-5-6-13)21-9-14(16)12(3)4/h7,9-13H,5-6,8H2,1-4H3,(H3,20,22,23,24)	UCVCWQOREWFCBG-UHFFFAOYSA-N	656948	5-((2- cyclopropyl-5- isopropyl- pyridin-4- yl)oxy)-N4- isobutyl- pyrimidine- 2,4-diamine::US11919918, Compound C194	P2X purinoceptor 2/3	Homo sapiens		 446							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656948	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656948&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124095	496176014							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385126	COc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)=C	InChI=1S/C13H15N5O2/c1-7(2)8-5-16-11(19-3)4-9(8)20-10-6-17-13(15)18-12(10)14/h4-6H,1H2,2-3H3,(H4,14,15,17,18)	TYZMBZZLUNQFAR-UHFFFAOYSA-N	656936	5-((2-methoxy- 5-(prop-1-en-2- yl)pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C164::US11919918, Compound C196	P2X purinoceptor 2/3	Homo sapiens		 652							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656936	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656936&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			152868778	496176002							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385127	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCN	InChI=1S/C14H19BrN6O/c1-8(2)9-6-19-12(15)5-10(9)22-11-7-20-14(17)21-13(11)18-4-3-16/h5-8H,3-4,16H2,1-2H3,(H3,17,18,20,21)	PYSAICXNVDVULB-UHFFFAOYSA-N	656951	US11919918, Compound C199	P2X purinoceptor 2/3	Homo sapiens		 333							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656951	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656951&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			154697535	496176016							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385128	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCOCCO	InChI=1S/C16H22BrN5O3/c1-10(2)11-8-20-14(17)7-12(11)25-13-9-21-16(18)22-15(13)19-3-5-24-6-4-23/h7-10,23H,3-6H2,1-2H3,(H3,18,19,21,22)	FAZQNWYADVZXAG-UHFFFAOYSA-N	656952	2-(2-((2-amino- 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4- yl)amino)ethoxy) ethanol::US11919918, Compound C201	P2X purinoceptor 2/3	Homo sapiens		 498							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656952	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656952&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155130574	496176017							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385129	CNCCNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C	InChI=1S/C15H21BrN6O/c1-9(2)10-7-20-13(16)6-11(10)23-12-8-21-15(17)22-14(12)19-5-4-18-3/h6-9,18H,4-5H2,1-3H3,(H3,17,19,21,22)	IAWWKXZDWKSOBR-UHFFFAOYSA-N	656953	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- (methylamino) ethyl)pyrimidine- 2,4-diamine::US11919918, Compound C202	P2X purinoceptor 2/3	Homo sapiens		 166							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656953	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656953&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			147883534	496176018							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385130	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCN1CCOCC1	InChI=1S/C18H25BrN6O2/c1-12(2)13-10-22-16(19)9-14(13)27-15-11-23-18(20)24-17(15)21-3-4-25-5-7-26-8-6-25/h9-12H,3-8H2,1-2H3,(H3,20,21,23,24)	FGTBVSNRMXRNGF-UHFFFAOYSA-N	656954	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- morpholinoethyl) pyrimidine-2,4- diamine::US11919918, Compound C203	P2X purinoceptor 2/3	Homo sapiens		 275							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656954	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656954&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			150158499	496176019							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385131	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCC(O)CO	InChI=1S/C15H20BrN5O3/c1-8(2)10-5-18-13(16)3-11(10)24-12-6-20-15(17)21-14(12)19-4-9(23)7-22/h3,5-6,8-9,22-23H,4,7H2,1-2H3,(H3,17,19,20,21)	SEOCWZOADCEZCL-UHFFFAOYSA-N	656955	3-((2-amino-5- ((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4- yl)amino)propane- 1,2-diol::US11919918, Compound C204	P2X purinoceptor 2/3	Homo sapiens		 56.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656955	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656955&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124166	496176020							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385132	COCCNc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C	InChI=1S/C15H20BrN5O2/c1-9(2)10-7-19-13(16)6-11(10)23-12-8-20-15(17)21-14(12)18-4-5-22-3/h6-9H,4-5H2,1-3H3,(H3,17,18,20,21)	QIRCKPWWYRZIGW-UHFFFAOYSA-N	656956	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- methoxyethyl) pyrimidine-2,4- diamine::US11919918, Compound C207	P2X purinoceptor 2/3	Homo sapiens		 163							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656956	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656956&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124154	496176021							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385133	CSc1cc(Oc2cnc(N)nc2N)c(cn1)C(C)=C	InChI=1S/C13H15N5OS/c1-7(2)8-5-16-11(20-3)4-9(8)19-10-6-17-13(15)18-12(10)14/h4-6H,1H2,2-3H3,(H4,14,15,17,18)	KCCROHRVXBGCSG-UHFFFAOYSA-N	656957	5-((2- (methylthio)-5- (prop-1-en-2- yl)pyridin-4- yl)oxy) pyrimidine- 2,4-diamine::US11919918, Compound C208	P2X purinoceptor 2/3	Homo sapiens		 106							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656957	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656957&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124153	496176022							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385134	CC[C@@H](CO)Nc1nc(N)ncc1Oc1cc(Br)ncc1C(C)C	InChI=1S/C16H22BrN5O2/c1-4-10(8-23)21-15-13(7-20-16(18)22-15)24-12-5-14(17)19-6-11(12)9(2)3/h5-7,9-10,23H,4,8H2,1-3H3,(H3,18,20,21,22)/t10-/m0/s1	LFYGPDQOVAJAJS-JTQLQIEISA-N	656958	(S)-2-((2-amino- 5-((2-bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin-4-yl) amino)but-1-ol::US11919918, Compound C209	P2X purinoceptor 2/3	Homo sapiens		 209							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656958	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656958&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124159	496176023							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385135	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NCCN1CCCC1	InChI=1S/C18H25BrN6O/c1-12(2)13-10-22-16(19)9-14(13)26-15-11-23-18(20)24-17(15)21-5-8-25-6-3-4-7-25/h9-12H,3-8H2,1-2H3,(H3,20,21,23,24)	YTMXRNWUCVEAOA-UHFFFAOYSA-N	656959	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N4-(2- (pyrrolidin-1- yl)ethyl) pyrimidine-2,4- diamine::US11919918, Compound C210	P2X purinoceptor 2/3	Homo sapiens		 399							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656959	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656959&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124148	496176024							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385136	CC(C)c1cnc(cc1Oc1cnc(N)nc1NCCO)C#C	InChI=1S/C16H19N5O2/c1-4-11-7-13(12(8-19-11)10(2)3)23-14-9-20-16(17)21-15(14)18-5-6-22/h1,7-10,22H,5-6H2,2-3H3,(H3,17,18,20,21)	YHDIEVLGUSQXQC-UHFFFAOYSA-N	656960	2-((2-amino-5-((2- ethynyl-5- isopropylpyridin- 4- yl)oxy)pyrimidin- 4-yl)amino)ethanol::US11919918, Compound C211	P2X purinoceptor 2/3	Homo sapiens		 121							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656960	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656960&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124163	496176025							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385137	CC(C)Nc1nc(N)ncc1Oc1cc(ncc1C(C)C)C#C	InChI=1S/C17H21N5O/c1-6-12-7-14(13(8-19-12)10(2)3)23-15-9-20-17(18)22-16(15)21-11(4)5/h1,7-11H,2-5H3,(H3,18,20,21,22)	UJADEXKGQLLXLW-UHFFFAOYSA-N	656961	US11919918, Compound C212	P2X purinoceptor 2/3	Homo sapiens		 123							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656961	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656961&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			154697532	496176026							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385138	CNc1nc(N)ncc1Oc1cc(ncc1C(C)C)C#C	InChI=1S/C15H17N5O/c1-5-10-6-12(11(7-18-10)9(2)3)21-13-8-19-15(16)20-14(13)17-4/h1,6-9H,2-4H3,(H3,16,17,19,20)	SGFWCSOFJRTTSA-UHFFFAOYSA-N	656962	5-((2-ethynyl-5- isopropylpyridin- 4-yl)oxy)-N4- methylpyrimidine- 2,4-diamine::US11919918, Compound C213	P2X purinoceptor 2/3	Homo sapiens		 295							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656962	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656962&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			151838871	496176027							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385139	CCNc1cc(Oc2cnc(N)nc2NC)c(cn1)C(C)=C	InChI=1S/C15H20N6O/c1-5-18-13-6-11(10(7-19-13)9(2)3)22-12-8-20-15(16)21-14(12)17-4/h6-8H,2,5H2,1,3-4H3,(H,18,19)(H3,16,17,20,21)	NQHQIQIXEGBYJO-UHFFFAOYSA-N	656963	US11919918, Compound C214	P2X purinoceptor 2/3	Homo sapiens		 72.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656963	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656963&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			171392713	496176028							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385140	CC(=C)c1cnc(cc1Oc1cnc(N)nc1N)C#C	InChI=1S/C14H13N5O/c1-4-9-5-11(10(6-17-9)8(2)3)20-12-7-18-14(16)19-13(12)15/h1,5-7H,2H2,3H3,(H4,15,16,18,19)	OTAPLTATGFXASH-UHFFFAOYSA-N	656964	5-((2-ethynyl- 5-(prop-1-en- 2-yl)pyridin- 4-yl)oxy) pyrimidine-2,4- diamine::US11919918, Compound C215	P2X purinoceptor 2/3	Homo sapiens		 194							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656964	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656964&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148827576	496176029							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385141	CC(C)c1cnc(cc1Oc1cnc(N)nc1NCC(O)CO)C#C	InChI=1S/C17H21N5O3/c1-4-11-5-14(13(7-19-11)10(2)3)25-15-8-21-17(18)22-16(15)20-6-12(24)9-23/h1,5,7-8,10,12,23-24H,6,9H2,2-3H3,(H3,18,20,21,22)	AGYFXRNEMIJQTN-UHFFFAOYSA-N	656965	3-((2-amino-5-((2- ethynyl-5- isopropylpyridin- 4- yl)oxy)pyrimidin- 4- yl)amino)propane- 1,2-diol::US11919918, Compound C216	P2X purinoceptor 2/3	Homo sapiens		 65.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656965	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656965&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124091	496176030							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385142	CC(C)c1cnc(Cl)cc1Oc1cnc(NC(CO)CO)nc1N	InChI=1S/C15H20ClN5O3/c1-8(2)10-4-18-13(16)3-11(10)24-12-5-19-15(21-14(12)17)20-9(6-22)7-23/h3-5,8-9,22-23H,6-7H2,1-2H3,(H3,17,19,20,21)	XKNOJCAJUXXJRE-UHFFFAOYSA-N	656966	2-((4-amino-5- ((2-chloro-5- isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) propane-1,3-diol::US11919918, Compound C218	P2X purinoceptor 2/3	Homo sapiens		 383							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656966	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656966&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124158	496176031							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385143	CC(C)c1cnc(Br)cc1Oc1cnc(N)nc1NNC(=O)OC(C)(C)C	InChI=1S/C17H23BrN6O3/c1-9(2)10-7-20-13(18)6-11(10)26-12-8-21-15(19)22-14(12)23-24-16(25)27-17(3,4)5/h6-9H,1-5H3,(H,24,25)(H3,19,21,22,23)	QGQVMHZDHBSHPF-UHFFFAOYSA-N	656967	US11919918, Compound C222::tert-butyl 2-(2- amino-5-((2- bromo-5- isopropylpyridin- 4-yl)oxy) pyrimidin- 4-yl)hydrazine- 1-carboxylate	P2X purinoceptor 2/3	Homo sapiens		 40.0							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656967	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656967&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124157	496176032							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385144	CC(C)c1cnc(Br)cc1Oc1cnc(NCCO)nc1NCCO	InChI=1S/C16H22BrN5O3/c1-10(2)11-8-20-14(17)7-12(11)25-13-9-21-16(19-4-6-24)22-15(13)18-3-5-23/h7-10,23-24H,3-6H2,1-2H3,(H2,18,19,21,22)	YHIOLCMCLRXKRZ-UHFFFAOYSA-N	656968	US11919918, Compound C226	P2X purinoceptor 2/3	Homo sapiens		 155							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656968	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656968&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			152520098	496176033							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385145	CC(C)c1cnc(cc1Oc1cnc(NC(CO)CO)nc1N)C#C	InChI=1S/C17H21N5O3/c1-4-11-5-14(13(6-19-11)10(2)3)25-15-7-20-17(22-16(15)18)21-12(8-23)9-24/h1,5-7,10,12,23-24H,8-9H2,2-3H3,(H3,18,20,21,22)	MQZWDJDIDPZYBO-UHFFFAOYSA-N	656970	2-((4-amino- 5-((2-ethynyl- 5-isopropyl- pyrdin-4- yl)oxy) pyrimidin-2- yl)amino) propane-1,3-diol::US11919918, Compound C228	P2X purinoceptor 2/3	Homo sapiens		 125							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656970	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656970&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			148534921	496176035							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385146	CC(C)c1cnc(cc1Oc1cnc(NCC(O)CO)nc1N)C#C	InChI=1S/C17H21N5O3/c1-4-11-5-14(13(7-19-11)10(2)3)25-15-8-21-17(22-16(15)18)20-6-12(24)9-23/h1,5,7-8,10,12,23-24H,6,9H2,2-3H3,(H3,18,20,21,22)	PZTYGEXXYPKZJJ-UHFFFAOYSA-N	656971	3-((4-amino- 5-((2-ethynyl- 5-isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) propane-l,2-diol::US11919918, Compound C229	P2X purinoceptor 2/3	Homo sapiens		 113							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656971	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656971&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124160	496176036							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385147	CC(C)c1cnc(cc1Oc1cnc(NCCO)nc1N)C#C	InChI=1S/C16H19N5O2/c1-4-11-7-13(12(8-19-11)10(2)3)23-14-9-20-16(18-5-6-22)21-15(14)17/h1,7-10,22H,5-6H2,2-3H3,(H3,17,18,20,21)	ZXIDAHPYCRJDPU-UHFFFAOYSA-N	656972	2-((4-amino- 5-((2-ethynyl- 5-isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) ethanol::US11919918, Compound C230	P2X purinoceptor 2/3	Homo sapiens		 106							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656972	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656972&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124149	496176037							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385148	CC(C)Nc1ncc(Oc2cc(ncc2C(C)C)C#C)c(N)n1	InChI=1S/C17H21N5O/c1-6-12-7-14(13(8-19-12)10(2)3)23-15-9-20-17(21-11(4)5)22-16(15)18/h1,7-11H,2-5H3,(H3,18,20,21,22)	QTVZTOWEFAZUSO-UHFFFAOYSA-N	656973	5-((2-ethynyl- 5-isopropyl- pyrdin-4-yl)oxy)- N2-isopropyl- pyrmidine-2,4- diamine::US11919918, Compound C233	P2X purinoceptor 2/3	Homo sapiens		 125							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656973	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656973&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			149097298	496176038							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385149	CC(C)c1cnc(Br)cc1Oc1cnc(NCC(O)CO)nc1N	InChI=1S/C15H20BrN5O3/c1-8(2)10-5-18-13(16)3-11(10)24-12-6-20-15(21-14(12)17)19-4-9(23)7-22/h3,5-6,8-9,22-23H,4,7H2,1-2H3,(H3,17,19,20,21)	VCUSKAIJOFOHAB-UHFFFAOYSA-N	656974	3-((4-amino-5- ((2-bromo-5- isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino) propane- 1,2-diol::US11919918, Compound C235	P2X purinoceptor 2/3	Homo sapiens		 145							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656974	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656974&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124181	496176039							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385150	CC(C)c1cnc(Br)cc1Oc1cnc(NCCO)nc1N	InChI=1S/C14H18BrN5O2/c1-8(2)9-6-18-12(15)5-10(9)22-11-7-19-14(17-3-4-21)20-13(11)16/h5-8,21H,3-4H2,1-2H3,(H3,16,17,19,20)	MNMSVFJDRFNAHP-UHFFFAOYSA-N	656975	2-((4-amino-5- ((2-bromo-5- isopropyl- pyridin-4- yl)oxy) pyrimidin-2- yl)amino)ethanol::US11919918, Compound C236	P2X purinoceptor 2/3	Homo sapiens		 134							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656975	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656975&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124161	496176040							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385151	CNc1ncc(Oc2cc(Br)ncc2C(C)C)c(N)n1	InChI=1S/C13H16BrN5O/c1-7(2)8-5-17-11(14)4-9(8)20-10-6-18-13(16-3)19-12(10)15/h4-7H,1-3H3,(H3,15,16,18,19)	BCYBLDAMYYNWEX-UHFFFAOYSA-N	656976	US11919918, Compound C237	P2X purinoceptor 2/3	Homo sapiens		 781							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656976	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656976&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			149749701	496176041							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385152	CC(C)c1cnc(Br)cc1Oc1cnc(NC2CC2)nc1N	InChI=1S/C15H18BrN5O/c1-8(2)10-6-18-13(16)5-11(10)22-12-7-19-15(21-14(12)17)20-9-3-4-9/h5-9H,3-4H2,1-2H3,(H3,17,19,20,21)	PZEMWICRKUFKQT-UHFFFAOYSA-N	656977	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N2- cyclopropyl- pyrimidine-2,4- diamine::US11919918, Compound C238	P2X purinoceptor 2/3	Homo sapiens		 206							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656977	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656977&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124092	496176042							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638						
1385153	CC(C)Nc1ncc(Oc2cc(Br)ncc2C(C)C)c(N)n1	InChI=1S/C15H20BrN5O/c1-8(2)10-6-18-13(16)5-11(10)22-12-7-19-15(20-9(3)4)21-14(12)17/h5-9H,1-4H3,(H3,17,19,20,21)	OUIMGNLURISCRW-UHFFFAOYSA-N	656978	5-((2-bromo-5- isopropylpyridin- 4-yl)oxy)-N2- isopropyl- pyrimidine- 2,4-diamine::US11919918, Compound C239	P2X purinoceptor 2/3	Homo sapiens		 131							US Patent		10.7270/Q24F1W1X			US11919918	Zhao, Y; Wang, H; Li, G; Li, X; Jiang, Y; Liu, K; Wang, Y; Zhou, L; Liu, Y; Shao, N; Xiao, F	BEIJING TIDE PHARMACEUTICAL CO., LTD.	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=656978	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=284&target=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=656978&enzyme=P2X+purinoceptor+2%2F3&column=ki&startPg=0&Increment=50&submit=Search			155124094	496176043							2	MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH		P2X purinoceptor 3	P2RX3_HUMAN	P56373	Q6DK37 Q9UQB6							MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL		P2X purinoceptor 2	P2RX2_HUMAN	Q9UBL9	A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7 Q9Y637 Q9Y638